ABSTRACT The study was conducted at University of Ilorin Teaching and Research Farm of the Faculty of Agriculture, in the Southern Guinea Savanna Zone of Nigeria, during 2010/2011 raining season. The study was carried out on the effect of population density on growth and yield of Jatropha curcas. A field experiment was carried out using, Randomized Completely Block Design. Treatments were randomly allocated to each block and each treatment was replicated three times. The treatments were obtained by using 5 plant populations. The population used include: the highest population of 10,000 plants per hectare at 1m x 1m spacing, followed by 2500 plants per hectare at 2m x 2m spacing, 1,111 plants per hectare at 3m x 3m spacing, 650 plants per hectare at 4m x 4m spacing, and 400 plants per hectare at 5m x 5m spacing. Data were collected on the following growth parameters: survival percentage, number of buds per plant, bud length, plant height, number of leaf per plant, total plant biomass, and physiological growth indices, and yield parameters. Results showed that survival percentage increased with decreased in population densities, and there was a significant difference at 28 days after planting, although all the population attained a 100% survival at 35days after planting. From the analysis of variance, the difference in mean values of the plant height was significant (p< 0.05) during the later stage of the vegetative growth. The bud length, the number of leaves per plant, plant weight, and the root lengths, were higher at high population densities, and these growth parameters contribute to the yield of Jatropha curcas at high densities on hectare bases. Therefore the yield was significantly higher, at high population densities than at low population densities. In this case, all the parameters have significant (0.05) differences between their mean values.