PUBLICATIONS AND ABSTRACTS

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CURRICULUM VITAE
Name:
DOB:
Birth Place:
Citizenship:
Gerald de Haan
August 21, 1965
Drachten, the Netherlands
the Netherlands
Education:
University of Groningen, Groningen, the Netherlands Prop.exam. 1983 Social Sciences
University of Groningen, Groningen, the Netherlands M.SC.
1990 Medical Biology
University of Groningen, Groningen, the Netherlands Ph.D.
1995 Hematology
Professional experience:
2009-present:
Scientific Director ERIBA (European Institute on the Biology of Aging)
2005-present:
Professor, Dept. of Stem Cell Biology, University Medical Center
Groningen.
Aug. 2005:
Sabbatical leave to Genomics Institute of the Novartis Research
Foundation (GNF), San Diego, CA.
2005-2009:
Member Research Advisory Committee Groningen University Medical
Center
July 2002:
Sabbatical leave to Genomics Institute of the Novartis Research
Foundation (GNF), San Diego, CA.
2003-2005:
Associate Professor, Dept. of Stem Cell Biology, University of Groningen.
July 2000:
Sabbatical leave in lab of Dr. Ihor Lemischka, Dept. Mol.Biol., Princeton
University, Princeton, NJ., USA
1998-2003:
Research Scientist, Experimental Hematology, Groningen institute for
Drug Studies, Groningen, the Netherlands.
1995-1998:
Post-doctoral fellow in the lab of Prof.Dr. Gary Van Zant, Blood and
Marrow Transplant Program, Division of Hematology/Oncology,
University of Kentucky, Lexington, KY, USA
1991-1995:
PhD student at the Groningen Institute for Drug Studies, Department of
Hematology/Physiological Chemistry, University of Groningen, the
Netherlands (Advisors: Dr. Willem Nijhof and Prof.Dr. Markus Loeffler,
University of Cologne/Leipzig, Germany).
Memberships:
Member of International Society for Experimental Hematology (ISEH) since 1995.
Member of American Society of Hematology (ASH) since 1996.
Member of the Complex Trait Consortium since 2001.
Member International Society for Stem Cell Research since 2005.
2000-present: Member PvdA (Dutch Social Democrat Party)
2003-2007: Member Advisory Committee Technology Foundation STW project “Growing
Blood”
2004-2007: Member Advisory Committee Technology Foundation STW project “Engineering
Vaccine Cartridges”.
2004-2010: Lid Commissie Wetenschap en Beroep Fakulteit Med.Wetenschappen (0,1 fte).
2004-2008: Lid Beroepenveldcommissie Noordelijke Hogeschool Leeuwarden/Van Hall
Instituut.
2003-2008: Gebruikerscommissie CDL, Klankbordgroep Nieuwbouw CDL.
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2003-2008. Member VENI grant evaluation committee Groningen University Medical Center
2008-present: Member VIDI grant evaluation committee Groningen University Medical Center
April 2002, January 2005, November 2007, January 2009. Member Expert Review Panel
Framework Program 6 and 7, European Union.
2005-2008. Member Web Site Advisory Committee International Society for Stem Cell
Research.
2006-2008. Councillor Representative of ISEH Awards Committee.
2006-2009. Councillor for the Board of Trustees of the International Society for Experimental
Hematology.
2006. Lid Werkgroep Regeneratieve Geneeskunde, Koninklijke Nederlandse Academie voor
Wetenschappen (KNAW).
2006-present: Member INSERM expert scientific review team (French National Institute of
Health).
2006-present. Member VIDI grant study section, Netherlands Organization for Scientific
Research.
2008. Lid ZonMW werkgroep Verkenning Adulte Stamcellen voor Ministerie VWS.
2008-present Chair Junior Investigator Committee International Society for Stem Cell Research
2008-2009. Member Biotechnology Committee, Teldersstichting (Advisory Office Dutch Liberal
Party).
2009-2014. Lid commissie Translationeel Adult Stamcelonderzoek, ZonMW
2009-present. Scientific Advisory Board Landsteiner Stichting voor Bloedtransfusie Research
(LSBR, Dutch Blood Bank Research Foundation )
2009-2010. Vice-President International Society for Experimental Hematology
2010-2013: Member Scientific Research Council (Wetenschappelijke Raad) Dutch Cancer
Society
2010-present: Founding member and Treasurer of Dutch Society for Stem Cell Research
2010-2011. President-Elect International Society for Experimental Hematology
2011-2012. President International Society for Experimental Hematology.
2010-2012. Member evaluation committee TOP Research grants, Netherlands Organization for
Scientific Research (NWO).
2010-2015. Board Member Netherlands Institute for Regenerative Medicine (NIRM)
2011-2014. Management Board Member Shared Ageing Research Models (ShARM)-Resource
(funded by the Wellcome Trust, maintained at University of Sheffield, UK).
Editorial board:
Editorial Board Experimental Hematology 2002-2004.
Editorial Board Stem Cells 2005-present.
Editorial Board Current Stem Cell Research and Therapy 2005-present.
Associate Editor Experimental Hematology 2011-2013.
Editorial Board Longevity and Healthspan 2011-present
Review activities:
Grants:
National: Netherlands Organization for Scientific Research NWO (VENI, VIDI, VICI,
Equipment grants), Dutch Cancer Society, Dutch Heart Foundation, Diabetes Fonds, Wilhelmina
Children’s Hospital Research Foundation Utrecht.
International:
UK: PPP Healthcare Medical Trust, The Wellcome Trust Programme grant, Leukaemia Research
Foundation (off-site and on-site), Research into Ageing-UK, Cancer Research UK, MRCMolecular
and
Cellular
Medicine
Board,
Children
with
Leukaemia,
Kay Kendall Leukaemia Fund .
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Italy: Italian Association of Cancer Research (AIRC).External Ad-Hoc Expert European Institute
of Oncology, Milan
Belgium: Flemish Institute of Biotechnology (VIB).
Austria: Austrian Science Fund.
USA: Barshop Institute for Longevity and Aging Studies, March of Dimes.
Portugal: Portugese Science and Technology Foundation.
Germany Review panel Deutsche Forschungsgemeinschaft Centre of Excellence, German
Federal Ministry of Education and Research (BMBF) 2007, 2011. Member Ulm University W3
Professor Recruitment Panel.
France: Member INSERM expert scientific review team (French National Institute of Health).
Spain: National Programme of Cooperative Research from the Spanish Ministry of Health and
Consumer's Affairs,
Papers: Reviewer for Nature, Nature Genetics, Nature Reviews Genetics, Cell Stem Cell,
Blood, Proc.Natl.Acad.Sci. USA, Journal of Experimental Medicine, Genome Research, Cancer
Research, Development, Journal of Hematotherapy, Stem Cells, Bone Marrow Transplantation,
Haematologica, Leukemia, Physiological Genomics, Experimental Gerontology, PloS Biology,
PlosOne, PloS Computational Biology, Plos Genetics, Methods in Molecular Biology (Humana
Press), Bioinformatics, Mechanisms of Aging and Development, Mammalian Genome, Aging
Cell, BMC Molecular Biology, BMC Genomics, Journal of Biomedicine and Biotechnology,
Frontiers in Neuroscience, FASEB Journal.
Abstract reviewer for European Hematology Association-Meetings 2002, 2003, 2004, 2005,
2006, 2010, 2011. International Society for Stem Cell Research-Meeting 2006, 2007, 2008, 2009,
2010, 2011. International Society for Experimental Hematology 2006, 2007, 2009, 2010, 2011.
Royan International Research Award 2009 (Iran)
Book Review: “Stem Cell Assays” for Molecular Biotechnology
Site Visits: Site visit Laboratory Animal Facility Dutch Cancer Institute (NKI), May 11, 2011
Other Academic Activities: Member Scientific Misconduct Committee University of Lund
2011.
Meeting organization:
2001. Member Program committee 24th Meeting of the European Study Group of Cell
Proliferation, June 14-14, 2001, Leipzig, Germany
2005. Chairman/organizer of the 4th Annual Meeting of the Complex Trait Consortium, June 2729, Groningen, the Netherlands.
2008: First Dutch Stem Cell Meeting, April 24, 2008. Haren, the Netherlands.
2008: Annual Meeting Eurythron, EU-FP6 Marie Curie Training Network. April 1-2, 2008.
Groningen, the Netherlands.
2009: EuroSystems Annual Consortium Meeting Chair, June Cambridge, UK
2009: Chair Annual Meeting International Society for Experimental Hematology, September 912, Athens, Greece.
2009: co-chair Systems Genetics: from microbe to mouse to man. Oct1-2, Groningen, the
Netherlands.
2010: Chair EuroSystems Annual Consortium Meeting, June Schiemonnikoog, the Netherlands.
2010: Organizing Committee Annual Meeting Stem Cells in Development and Disease-NIRM,
Krasnapolsky Hotel Amsterdam, October 2010.
2011: co-chair Systems Genetics: from man to microbe, from genotype to phenotype. September
29-30, Groningen, the Netherlands.
2011: Netherlands Institute for Regenerative Medicine Meeting, September 20, Amsterdam.
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2011. Chair Scientific Program Committee Annual Meeting International Society for
Experimental Hematology, Vancouver
2012: Chair Advances in Stem Cell Research VI. Kransjka Gora, Slovenia. January 23-27.
External PhD Thesis Committee:
July 1, 2005: Els Henkaerts, University of Antwerp, Belgium.
January 25, 2006, Gerjo Velders, University of Leiden, the Netherlands
May 11, 2007, Bas Siebum, University of Twente, Enschede, the Netherlands
May 22, 2008, Cristina Pina, Oxford University, UK.
December 12 2008, Cornelis Jan Pronk, Lund University, Sweden.
October 22, 2009, Jojanneke Jukes, University of Twente, Enschede, the Netherlands.
August 13, 2010, Heide Rye Hudlebusch, University of Copenhagen, Denmark.
December 2010, Sarah Ellis, University of Melbourne, Australia.
July 6, 2011, Hugo Andre Alves, University of Twente, Enschede, the Netherlands.
December 2011, Götz Hartleben, University of Jena, Germany
December 2011, Alexander de Bruin, University of Amsterdam, the Netherlands
Grants/Awards:
1994: Winner of the Bekales-Leukemia prize 1994, awarded by the Fonds Nationale de la
Recherche Scientifique: "The effects of simultaneous use of growth factors and cytostatic drugs
in vitro and in vivo on normal and leukemic cells".
1995: Nominated for the "New Investigator Award 1995" at the annual meeting of the
International Society for Experimental Hematology, Duesseldorf, Germany.
1995: PhD thesis: “Cum laude”.
1995: Co-investigator of Dutch Cancer Society project: RUG 96-1204: Hemopoietic stem cell
toxicity, exhaustion and protection: in vivo interactions between growth factors, cytotoxic drugs
and leukemic cells.
1996: "TALENT-stipend" of the Netherlands Organization for Scientific Research (NWO) to
support post-doctoral work in the lab of Dr.Gary Van Zant.
1998-2000: Principal Investigator of NWO project “Mutation analysis to identify genes
controlling proliferation and frequency of hemopoietic stem cells”.
1998: Bekales Leukemia Grant, awarded by the Fonds Nationale de la Recherche Scientifique:
“Mapping of leukemia and stem cell cycling genes in leukemia-sensititve and resistant strains of
mice”.
1998: Third place in the “New Investigator Award 1998” at the annual meeting of the
International Society for Experimental Hematology, Vancouver, BC. Canada.
1998: Internal small equipment grant J.K. de Cock Stichting.
1998-1999. Research grant Amgen Inc.: “Pharmacogenomics of SD-01”.
1999-2004: Fellow of the Royal Netherlands Academy of Arts and Sciences (KNAW).
2000-2004:Principal Investigator of Dutch Cancer Society grant 2000-2183:” The role of
fibroblast growth factor-1 and its receptor, Fgfr-1, in the regulation of normal and malignant
hematopoietic stem cell numbers.
2000-2004:Principal Investigator of Dutch Cancer Society grant 2000-2182:” Genetic mouse
models to predict hematopoietic recovery after chemotherapy; impact for the clinical practice”.
2000-2004: Principal investigator of Netherlands Organization for Scientific Research (NWO)Grant 901-08-339:” Aging of genetically distinct hematopoietic stem cell populations studied in
mouse embryo- and radiation-chimeras.
2001: Research grant Immunex Corp.: In vivo differentiation of hematopoietic stem cells to
hepatocytes by Flt3-ligand.
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2001-2004: Development and validation of a novel quantitative model of the hematopoietic stem
cell system. Funded by the Deutsche Forschungsgemeinschaft (DFG), in collaboration with Prof.
Dr. M. Loeffler, University of Leipzig, BRD.
2002-2006: Netherlands Organization for Scientific Research (NWO)-Grant 908-02-005:
Plasticity of adult somatic stem cells.
2002-2006: Research grant Ubbo Emmius Foundation: Targeting stem cells to the bone marrow:
mechanisms and applications in hematopoietic stem cell transplantation.
2002: Genomics Fellowship awarded by the Netherlands Organization for Scientific Research
(NWO-050-010-202).
2002: Boerhaave Award, awarded by the Herman Boerhaave Committee of the Leiden University
Medical Center.
2003-2007: Co-Investigator of Dutch Cancer Society grant 2003-2909:” Protection against
radiation-induced damage to salivary glands by stem cell transplantation.
2003-2007: Principal investigator National Institutes of Health grant RO1 HL 073710-01:
Expansion of stem cells by fibroblast growth factor-1 (U$1,100,000).
2003: Research Award 2003 University Medical Center Groningen (best researcher of the year,
award amount: €100,000).
2004-2006: FIRST; European Union FP6 Integrated Project: Use of adult stem cells to relieve
radiotherapy toxicity (€ 200,000).
2004-2007: Eurythron: European Union Marie Curie Training Network. Molecular control of
erythropoiesis (€ 210,000).
2004-2005: Research grant Amgen Inc. KGF and G-CSF to reduce radiation-induced damage to
salivary glands (€ 160,000). Co-investigators Piet Wierenga & Rob Coppes.
2004-2008: BSIK grant Dutch Ministry of Economic Affairs (€ 337,000 + 50% matching). Dutch
Platform for Tissue Engineering.
2005: Co-investigator Netherlands Organization for Scientific Research (NWO)-Grant 40-0050698-05-011: Multicolor Flow Cytometric Analyzer. (€220,000 + 25% matching).
2006: Research Award 2006 University Medical Center Groningen (best researcher of the year,
award amount: €100,000).
2007-2011. Principle investigator VICI grant awarded by the Netherlands Organization for
Scientific Research (NWO): A functional screen to identify genes controlling hematopoietic stem
cell selfrenewal and senescence (€1,250,000).
2007-2010. Principal Investigator of Dutch Cancer Society grant 2007-3729. A
myeloproliferative syndrome induced by the Polycomb Group Gene Ezh2: mechanisms and
interventions. (€500,000).
2007-2011. Principle Investigator Horizon Genomics Grant 050-71-055 awarded by the
Netherlands Genomics Initiative: A genetical genomics approach to identify genes and gene
networks specifying hematopoietic stem cell fate. (€499,500).
2008-2012. Deputy-Coordinator EuroSysStem, European Federation for Systematic Stem Cell
Biology, European Union FP7 Collaborative Project. (€ 440,000, total grant €12,000,000)
2008-2010. Co-investigator Landsteiner Stichting voor Bloedtransfusie Research: Improvement
of the long-term function of transplanted hematopoietic stem cells. PI: RP van Os (€229,500)
2008-2012. Co-Investigator of Dutch Cancer Society grant RUG 2008-4022: Cell therapy to
reduce radiation-toxicity to salivary glands. (€500,000).
2008: Associate Member BSIK Stem Cells in Development and Disease. Dutch Ministry of
Economic Affairs.
2008-2012: Principle Investigator ALW grant awarded by the Netherlands Organization for
Scientific Research (NWO): (€220,000)
2008-2012: STEMEXPAND, European Union FP7 Collaborative Project. (€ 440,000, total grant
€3,200,000)
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2009-2012: Co-investigator of Dutch Cancer Society grant 2009-4275: Untavelling BMI1induced self-renewal of leukemic stem cells: a potential target for clinical intervention?
(€524,200) (PI Dr. JJ Schuringa).
2009-2017: Co-investigator Ministry of Health Program for Adult Translational Stem Cell
Research 40-41400-98-9023 (PI Dr. RP Coppes): Transplantation of Adult Salivary Gland Stem
Cells to Restore Salivary Gland Function after Radiotherapy"(€2000,000).
2010-2014: Co-investigator of Dutch Cancer Society grant 2009-4411: BMI1 collaborates with
Bcr-Abl in leukemic transformation in CML: Identification of mechanisms and potential
therapeutic targets (€524,200) (PI Dr. JJ Schuringa).
2011-2014: Co-investigator EuroCancer Stem Cell Training Network. Marie Curie Initial
Training Networks, European Union FP7. (€200,000).
2011-2014: Co-investigator HEM_ID HEMatopoietic cell IDentity: genetic and epigenetic
regulation in normal and malignant hematopoiesis. Marie Curie Initial Training Networks,
European Union FP7. (€200,000).
2011-2016: Netherlands Institute for Regenerative Medicine, Dutch Ministery of Economic
Affairs, Agriculture and Innovation (€870,000).
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PUBLICATIONS
Publications
1.
de Haan G, Loeffler M, Nijhof W (1992). Long-term recombinant human granulocytecolony stimulating factor (rhG-CSF) treatment severely depresses murine marrow
erythropoiesis without causing an anemia. Experimental Hematology 20:600-605.
2.
de Haan G, Dontje B, Loeffler M, Nijhof W (1993). Microenvironmentally dependent
effects on murine hemopoiesis by a prolonged interleukin-1 treatment. British Journal of
Haematology 85:15-18.
3.
Nijhof W, de Haan G, Dontje B, Loeffler M (1994), Effects of G-CSF on erythropoiesis.
Annals of the New York Academy of Sciences, vol.718:312-325.
4.
de Haan G, Engel C, Dontje B, Nijhof W, Loeffler M (1994), The mutual inhibition of
erythropoiesis and granulopoiesis during combined erythropoietin, granulocyte colonystimulating factor and stem cell factor administration; in vivo interactions and dose
response surfaces. Blood 84: 4157-4163.
5.
de Haan G, Dontje B, Nijhof W, Loeffler M (1995). Effects of continuous stem cell
factor administration on normal and erythropoietin-stimulated murine hemopoiesis. Experimental results and model analysis. Stem Cells 13:65-76.
6.
de Haan G, Engel C, Dontje B, Loeffler M, Nijhof W (1995). Hemotoxicity by
prolonged etoposide administration to mice can be prevented by simultaneous growth
factor therapy. Cancer Research 55:324-329.
7.
Nijhof W, Dontje B, Pietens J, de Haan G (1995). Mechanistical options of
erythropoietin-stimulated erythropoiesis. Experimental Hematology 23:369-375.
8.
de Haan G, Engel C, Dontje B, Loeffler M, Nijhof W (1995). In vivo effects of
interleukin-11 and stem cell factor in combination with erythropoietin in the regulation of
erythropoiesis. British Journal of Haematology 90:783-790.
9.
de Haan G, Engel C, Dontje B, Loeffler M, Nijhof W (1995). The kinetics of murine
hemopoietic stem cells in vivo in response to prolonged increased mature blood cell
production, induced by G-CSF. Blood 86:2986-2992.
10.
de Haan G, Dontje B, Engel C, Loeffler M, Nijhof W (1996). Prophylactic pretreatment
of mice with hemopoietic growth factors results in expansion of primitive hemopoietic
cell compartments and protects against 5-fluorouracil-induced hemotoxicity. Blood
87:4581-4588.
11.
de Haan G, Dontje B, Nijhof W (1996). Concepts of hemopoietic cell amplification;
synergy, redundancy and pleiotropy of cytokines in the regulation of erythropoiesis.
Leukemia and Lymphoma 22:385-394.
12.
de Haan G, Nijhof W, Van Zant G (1997). Mouse strain-dependent changes in frequency
and proliferation of hemopoietic stem cells during aging: correlation between lifespan and
cycling activity. Blood 89:1543-1550.
13.
Van Zant G, de Haan G, Rich IN (1997). Alternatives to stem cell renewal from a
developmental viewpoint. Experimental Hematology 25:187-192.
14.
Down JD, de Haan G, Dillingh JH, Dontje B, Nijhof W (1997). Stem cell factor has
contrasting effects in combination with 5-fluorouracil or total body irradiation on
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frequencies of different hemopoietic cell subsets and engraftment of transplanted bone
marrow. Radiation Research 147: 680-685.
de Haan G and Van Zant G (1997). Intrinsic and extrinsic control of hemopoietic
stem cell numbers: mapping of a stem cell gene. Journal of Experimental Medicine 186:
529-536.
de Haan G, Van Zant G (1998). In vivo modulation of lymphohemopoietic stem cell
populations with cytokines, in Immune modulating agents, Kresina TF (ed), Marcel
Dekker, New York, page 55-74.
Roeder I, de Haan G, Engel C, Nijhof W, Dontje B, Loeffler M (1998). Interactions of
erythropoietin (EPO), granulocyte-colony stimulating factor (G-CSF), stem cell factor
(SCF) and interleukin-11 (IL-11) on murine hemopoiesis during simultaneous
administration. Blood 91:3222-3229.
de Haan G, Gelman R, Watson A, Yunis E, Van Zant G (1998). A putative gene causes
variability in lifespan among genotypically identical mice. Nature Genetics 19:114-116,
1998.
de Haan G, Van Zant G (1999). Genetic analysis of hemopoietic cell cyling in mice
suggests its involvement in organismal lifespan. FASEB. J 13:707-713.
de Haan G, Van Zant G (1999). Dynamic changes in mouse hematopoietic stem cell
numbers during aging. Blood 93:3294-3301.
Van Zant G, de Haan G (2000). Genetic control of lifespan - studies from animal
models. Expert Reviews in Molecular Medicine. http://www-ermm.cbcu.cam.ac.uk.
de Haan G, Ploemacher R (2002). The cobblestone area forming cell assay. In
“Hematopoietic Stem Cell Protocols” p143-151, Methods in Molecular Medicine, vol. 63
, Jordan CT, Klug C (eds), Humana Press.
de Haan G, Szilvassy SJ, Meyerrose TE, Dontje B, Grimes B, Van Zant G. (2000).
Distinct functional properties of highly purified hematopoietic stem cells from mouse
strains with small and large stem cell populations. Blood 96:1374-1379.
de Haan G, Ausema A, Wilkens M, Molineux G, Dontje B. (2000). Efficient
mobilization of hematopoietic progenitors after a single injection of pegylated
recombinant human G-CSF in mouse strains with distinct marrow cell pool sizes. Br. J.
Haematol. 110:638-646.
Kamminga LM, Akkerman I, Weersing E, Ausema A, Dontje B, Van Zant G, de Haan G
(2000). Autonomous behavior of hematopoietic stem cells. Experimental Hematology,
28:1451-1459
Geiger H, True JM, de Haan G, Van Zant G. (2001). Age- and stage-specific regulation
patterns in the hematopoietic stem cell hierarchy. Blood 98:2966-2972.
de Haan G. (2002) Hematopoietic stem cells: selfrenewing or aging? Cells Tissues
Organs, 171: 27-37.
de Haan G, Bystrykh LV, Weersing E, Dontje B, Geiger H, Ivanova N, Lemischka IR,
Vellenga E, Van Zant G. (2002). A genetic and genomic analysis identifies a cluster of
genes associated with hematopoietic cell turnover. Blood 100:2056-2062.
Noach S, Ausema A, Dillingh JH, Dontje B, Weersing E, Akkerman I, Vellenga E, de
Haan G. (2002). Growth factor treatment prior to low dose total body irradiation
increases donor cell engraftment after bone marrow transplantation in mice. Blood 100:
312-317.
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de Haan G, Van Zant G. (2002). Stem cells from birth to death: the history and the
future. AGE--Journal of the American Aging Association 25: 79-88.
Noach S, van Os R, Ausema A, Akkerman I, Weersing E, Dontje B, Vellenga E, de Haan
G. (2003). Chemotherapy-induced replicative stress on stem cells prior to autologous
bone marrow transplantation impairs long-term engraftment in mice. Experimental
Hematology 31:528-534, 2003.
de Haan G, Weersing E, Dontje B, van Os R, Bystrykh LV, Vellenga E, Miller G.
(2003). In vitro generation of long-term repopulating hematopoietic stem cells by FGF-1.
Developmental Cell 4: 241-251
de Haan, G, Wiersema A (2003). Stem cells: potential, selection and plasticity. In:
Cellular Engineering and Cellular Therapies. Smit Sibinga CTh, de Leij LFMH, eds.
Kluwer Àcademic PublishersDordrecht/Boston/London 2003:21-29
Biola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett B, Blankenhorn EP,
Blizard DA, Bolivar V, Brockmann GA, Buck KJ, Bureau JF, Casley WL, Chesler EJ,
Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G,
Dermant P, Doerge RW, Elliot RW, Farber CR, Flaherty L, Flint J, Gershenfeld H,
Gibson JP, Gu J, Gu W, Himmelbauer H, Hitzemann R, Hsu HC, Hunter K, Iraqi FF,
Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF,
Matthews DB, Medrano JF, Mehrabian M, Mittlemann G, Mock BA, Mogil JS,
Montagutelli X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O'Hara BF,
Osadchuk AV, Paigen B, Palmer AA, Peirce JL, Pomp D, Rosemann M, Rosen GD,
Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD,
Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA, Vadasz C, Van Zant G,
Wakeland E, Williams RW, Zhang HG, Zou F. The nature and identification of
quantitative trait loci: a community's view. Nat Rev Genet. 2003;4:911-916.
van Os R, de Haan G (2004). The balance between immune suppression, stem cell
ablation, competition, and engraftment. Blood 103: 2859.
Kamminga LM, van Os R, Ausema A, Weersing E, Dontje B, de Haan G (2005). Aging
of hematopoietic stem cells. In: Aging of hematopoietic stem cells. In: Klaus Sames,
Sebastian Sethe, Alexandra Stolzin (Eds.): Extending the lifespan. LIT Verlag Muenster
2005. ISBN 3-8258-8563-1.
van Os R, Kamminga LM, de Haan G (2004). Stem cell assays: something old,
something new, something borrowed. Stem Cells 22:1181-1190.
Kamminga L, van Os R, Ausema A, Noach EJK, Dontje B, Weersing E, Vellenga E, de
Haan G. (2005). Impaired Hematopoietic Stem Cell Functioning after Serial
Transplantation and during Normal Aging. Stem Cells 23:82-92.
Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty JT, Beavis WT,
Belknap JK, Bennett B, Berrettini W, Rickels KE, Bleich A, Bogue M, Broman KW,
Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, , Clapcote S, Cook MN,
Cox RD, Crabbe JC, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile
D, Garlow SJ, Geiger H, Gershenfeld H, Gu J, Gu W, de Haan G, Heller C, Lokey L,
Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi F, Ivandic B, Jacob HJ, Jansen
RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kooy RF,
Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R,
Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X,
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Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, O'Hara BF, Osadchuk AV, Page
GP, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M,
Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schalkwyk LC, Seltzer Z, Shimomura
K, Shou S,Sillanpää MJ, Snoeck HW, Spearow JL,Svenson K, Threadgill D, Toth
LA,Valdar W, Pardo F, de Villena M, Warden C, Whatley S, Williams RW, Wiltshire T,
Yi Y, Zhang D, Zhang M, Zou F (2004): The Collaborative Cross: A Community
Resource for the Genetic Analysis of Complex Traits. Nature Genetics 36:1133-1137.
Roeder I*, Kamminga LM*, Braesel K, Dontje B, de Haan G, Loeffler M (2005).
Competitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of
stem cell organization. Blood 105:609-616. *Equal contribution.
Bystrykh LV, Weersing E, Dontje B, Sutton S, Pletcher MT, Wiltshire T, Su AI, Vellenga
E, Wang J, Manly KF, Lu L, Chesler E, Alberts R, Jansen RC, Williams RW, Cooke M,
de Haan G. (2005) Uncovering regulatory pathways that affect hematopoietic stem cell
function using ‘genetical genomics’. Nature Genetics 37:225-232.
de Haan G and Williams RW (2005). A genetic and genomic approach to identify
longevity genes in mice. Mechanisms of Aging and Development, 126: 133-138.
van Pelt K, de Haan G, Vellenga E, Daenen SMGJ (2005). Administration of low dose
cytarabine results in immediate S-phase arrest and subsequent activation of cell cyling in
murine stem cells. Experimental Hematology 33:226-231.
de Haan G. (2005). A novel growth factor encoded by an old gene. Haematologica,
90:152.
Rudi Alberts, Peter Terpstra, Leonid V. Bystrykh, Gerald de Haan, Ritsert C. Jansen
(2005). A Statistical Multi-Probe Model for Analyzing Cis- and Trans-Genes in Genetical
Genomics Experiments with Short-Oligonucleotide Arrays. Genetics 171:1437.
de Haan G. (2005). Stamcellen, een inleiding. In “Het Medisch Jaar 2005” 64-70. red.
JN. Keeman, PW. De Leeuw, JA. Mazel, FG. Zitman. Bohn Stafleu van Loghum. ISBN
9031345482.
van Os R, Ausema A, Noach EJK, van Pelt K, Dontje B, Vellenga E, de Haan G. (2006)
Identification of quantitative trait loci regulating haematopoietic parameters in B6AKRF2
mice. Br J Haematol. 2006 Jan;132(1):80-90.
Kamminga LM, Bystrykh LV, de Boer A, Houwer S, Douma J, Weersing E, Dontje B, de
Haan G (2006). The Polycomb group gene Ezh2 prevents hematopoietic stem cell
exhaustion. Blood, 107(5):2170-9.
Kamminga LM and de Haan G. (2006). Cellular memory and hematopoietic stem cell
aging. Stem Cells, ;24(5):1143-9.
Lombaert IMA, Wierenga PK, Kok T, Kampinga HH, de Haan G, Coppes RP. (2006).
Mobilization of bone marrow stem cells by G-CSF ameliorates radiation-induced damage
to salivary glands. Clinical Cancer Research, 12:1804-12.
Peeters SDPWM, van der Kolk DM, de Haan G, Bystrykh L, Kuipers F, de Vries EGE,
Vellenga E. (2006). Selective Expression of Cholesterol Metabolism Genes In Normal
CD34+CD38- Cells With A Heterogeneous Expression Pattern in AML Cells,
Experimental Hematology, 34(5):622-30.
de Haan G, Gerrits A, Bystrykh LV (2006). Modern genome-wide genetic approaches to
reveal intrinsic properties of stem cells. Current Opinion in Hematology, 2006 13(4):24953.
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van Os, Ausema A, de Haan G (2007). In vitro assays for cobblestone area forming cells,
LTC-IC, and CFU-C. In “Hematopoietic Stem Cell Protocols”, Methods in Molecular
Medicine, vol. 430, second edition , Bunting K (eds), Humana Press. Page 143-157.
Yeoh JSG, van Os R, Weersing E, Ausema A, Dontje B, Vellenga E, de Haan G (2006).
Fibroblast growth factor-1 and 2 preserve long-term repopulating ability of hematopoietic
stem cells in serum-free cultures. Stem Cells, 24: 1564-1572.
Rizo A, Vellenga E, de Haan G, Schuringa JJ. (2006). Signalling pathways in
selfrenewing hematopoietic and leukemic stem cells; do all stem cells need a niche?
Human Molecular Genetics, 2006; 15 Spec No 2:R210-9.
Yeoh JSG and de Haan G. (2007). Fibroblast growth factors as regulators of stem cell
renewal and aging. Mechanisms of Ageing and Development, 128:17-24.
Chesler EJ, Bystrykh L, Cooke M, de Haan G, Manly K, Williams RW (2006).
Normalization procedures and detection of linkage signal in genetical-genomics
experiments. Nature Genetics 38:856-8.
Wierenga PK, Weersing E, Dontje B, de Haan G, van Os R. (2006). Differential role for
very late antigen-5 in mobilization and homing of hematopoietic stem cells. Bone
Marrow Transplant. 38:789-97.
van Os R, Kamminga LM, Ausema A, Bystrykh LV, Draijer DP, van Pelt K, Dontje B, de
Haan G (2007). A limited role for p21cip1/waf1 in maintaining normal hematopoietic
stem cell functioning. Stem Cells. 25:836-43.
de Haan G (2007). Latexin is a newly discovered regulator of hematopoietic stem cells.
Nat Genet. 39:141-2.
Yeoh JSG, Ausema A, Wierenga P, de Haan G, van Os R. (2007) Mobilized peripheral
blood stem cells provide rapid reconstitution but impaired long-term engraftment in a
mouse model. Bone Marrow Transplant. 39:401-9.
de Haan G and Gerrits A (2007). Epigenetic control of hematopoietic stem cell aging,
the case of Ezh2. Ann N Y Acad Sci. 2007 Jun;1106:233-9.
Alberts R, Terpstra P, Hardonk M, Bystrykh LV, de Haan G, Breitling R, Nap JP, Jansen
RC. (2007). A verification protocol for the probe sequences of Affymetrix genome arrays
reveals high probe accuracy for studies in mouse, human and rat. BMC Bioinformatics.
2007 Apr 20;8:132.
Wiersema AT, Dijk F, Dontje B, van der Want JJ, de Haan G. Cerebellar heterokaryon
formation increases with age and after irradiation. (2007). Stem Cell Research 1: 150154.
Dykstra BJ, de Haan G. (2008). Hematopoietic stem cell aging and self-renewal, Cell
Tissue Research, Cell Tissue Res. 2008 Jan;331(1):91-101;
Rizo A, Dontje B, Vellenga E, de Haan G, Schuringa JJ (2008): Long-term maintenance
of human hematopoietic stem/progenitor cells by expression of BMI1. Blood
111(5):2621-30.
Janine K. Kruit, A. Lyndsay Drayer, Vincent W. Bloks, Nel Blom, Sandra G. Olthof,
Pieter J. J. Sauer, Gerald de Haan, Ido P. Kema, Edo Vellenga, and Folkert Kuipers
(2008). Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia.
Journal of Biological Chemistry 283(10):6281-7.
Isabelle M.A. Lombaert, Jeanette F. Brunsting, Pieter K. Wierenga, Hette Faber, Monique
A. Stokman, Tineke Kok, H. Willy Visser, Harm H. Kampinga, Gerald de Haan, Robert
11
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P. Coppes. (2008). Rescue of salivary gland function after stem cell transplantation in
irradiated glands. PLoS ONE. 2008 Apr 30;3(4):e2063.
Gerrits, A, Dykstra B, Otten M, Bystrykh, L, de Haan G. (2008) Combining
transcriptional profiling and genetic linkage analysis to uncover gene networks operating
in hematopoietic stem cells and their progeny. Immunogenetics, 60(8):411-22
Lombaert IM, Brunsting JF, Wierenga PK, Kampinga HH, de Haan G, Coppes RP.
(2008). Keratinocyte Growth Factor Prevents Radiation Damage to Salivary Glands by
Expansion of the Stem/Progenitor Pool. Stem Cells. 2008 Oct;26(10):2595-60
Breitling R, Li Y, Tesson BM, Fu J, Wu C, Wiltshire T, Gerrits A, Bystrykh LV, de
Haan G, Su AI, Jansen RC. Genetical genomics: spotlight on QTL hotspots. PLoS Genet.
2008 Oct;4(10):e1000232. Epub 2008 Oct 24.
Lombaert IM, Brunsting JF, Wierenga PK, Kampinga HH, de Haan G, Coppes RP.
Cytokine treatment improves parenchymal and vascular damage of salivary glands after
irradiation. Clin Cancer Res. 2008 Dec 1;14(23):7741-50.
van Os R, de Haan G, Dykstra BJ (2009) .Hematopoietic stem cell quiescence: yet
another role for p53. Cell Stem Cell. 2009 Jan 9;4(1):7-8.
Rizo A, Olthof S, Han L, Vellenga E, de Haan G, Schuringa JJ. Repression of BMI1 in
normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis.
Blood. 2009. 114(8):1498-505.
Alice Gerrits, Yang Li, Bruno M. Tesson, Leonid V. Bystrykh, Ellen Weersing, Bertien
Dethmers-Ausema, Bert Dontje, Xusheng Wang, Rainer Breitling, Ritsert C. Jansen,
Gerald de Haan. Expression Quantitative Trait Loci are Highly Sensitive to Cellular
Differentiation State. Plos Genetics 2009. Oct;5(10):e1000692.
Gerrits A, Dykstra B, Kalmykowa OJ, Klauke K, Verovskaya E, Broekhuis M, de Haan
G, and Bystrykh LV (2010) Cellular Barcoding Tool for Clonal Analysis in the
Hematopoietic System. Blood 115: 2610-2618.
de Ridder J, Gerrits A, Bot J, de Haan G, Reinders M, Wessels L (2010). Inferring
combinatorial association logic networks in multimodal genome-wide screens.
Bioinformatics 26(12):i149-57.
Marcela Aparicio-Vergara, Ronit Shiri-Sverdlov, Gerald de Haan, Marten H. Hofker
(2010). Bone marrow transplantation in mice as a tool for studying the role of
hematopoietic cells in metabolic and cardiovascular diseases. Atherosclerosis,
Dec;213(2):335-44. Epub 2010 Jun 1.
Aleksandra Rizo, Sarah J. Horton, Sandra Olthof, Bert Dontje, Albertina Ausema, Ronald
van Os, Vincent van den Boom, Edo Vellenga, Gerald de Haan and Jan Jacob Schuringa
(2010). BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+
cells, Blood, Blood. 2010 Nov 25;116(22):4621-30. Epub 2010 Aug 19 .
Ronald van Os, Albertina Dethmers-Ausema, Bert Dontje, Manon van Riezen, Gooitzen
van Dam, and Gerald de Haan. (2010) Engraftment of syngeneic bone marrow is not
more efficient after intrafemoral transplantation than following traditional intravenous
administration. Experimental Hematology, Nov;38(11):1115-23. Epub 2010 Jul 17 .
Susanne M. Kooistra, Vincent van den Boom, Rajkumar P. Thummer, Frank Johannes,
René Wardenaar, Bruno M. Tesson, Liesbeth M. Veenhoff, Fabrizia Fusetti, Laura P.
O’Neill, Bryan M. Turner, Gerald de Haan, Bart J. L. Eggen (2010). UTF1 regulates ES
cell chromatin organization and gene expression. Stem Cells, Oct;28(10):1703-14.
12
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Klauke, K and de Haan G (2011). Polycomb group genes in hematopoietic stem cell
aging an malignancies. Int J Hematol. 2011 Jul;94(1):11-23,.
Woolthuis CM, de Haan G and Huls GA (2011). Aging of hematopoietic stem cells:
intrinsic changes or micro-environmental effects? Current Opinion in Immunology,
Aug;23(4):512-7.
Brad Dykstra, Sandra Olthof, Jaring Schreuder, Martha Ritsema, and Gerald de Haan
(2011). Clonal analysis reveals multiple functional defects of aged murine hematopoietic
stem cells. Journal of Experimental Medicine, in press.
Gerrits A, Walasek MA, Olthof S, Weersing E, Ritsema M, Zwart E, van Os R, Bystrykh
LV, de Haan G. (2011) Genetic Screen Identifies MicroRNA Cluster 99b/let-7e/125a as
a Regulator of Primitive Hematopoietic Cells, Blood, in press
13
PhD Theses
November 30, 2005. Leonie M. Kamminga. Hematopoietic stem cells and the genetics of aging.
ISBN 90-367-2312-4 (Promotor)
Februari 14, 2007. Joyce SG Yeoh. Regulatory role of Fibroblast Growth Factors on
hematopoietic stem cells. (Promotor). ISNB 90-367-2856-8
April 16, 2008. Isabelle I.M. Lombaert. Regeneration of irradiated salivary glands by stem cell
therapy. ISBN 978-90-367-3369-4 (Promotor).
July 4, 2011. Aleksandra Rizo-Crcareva. The polycomb gene Bmi1 in normal hematopoiesis and
leukemia (Promotor). ISBN 978-90-367-4968-8
September 7, 2011. Alice Gerrits. Exploiting natural and induced genetic variation to study
hematopoiesis (Promotor). ISBN 978-94-6182-002-0
14
Other Publications
1. Genetisch paspoort als cadeau. Gerald de Haan en Rinze Benedictus. Bijlage Opinie en
Debat, de Volkskrant 13 oktober 2010.
2. Gen-ethische verkenningen. Gerald de Haan. Liberaal Reveil, Juni, 2011.
15
INVITED LECTURES
2002
-A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell
turnover. Presented at the 1st Annual International Complex Trait Consortium Meeting,
Memphis TN, May 2002.
-Expansion of long-term repopulating hematopoietic stem cells by FGF-1. Vanderbilt Medical
School, Nashville, TN, May 2002.
-Stem cell expansion. Keynote lecture at the Dutch Society for Hematology Annual Meeting,
Lunteren, Netherlands, November 2002.
-Stem cell expansion by FGF-1. Institute of Hematology, Erasmus Medical Center, Rotterdam,
the Netherlands, March 2002.
-A genetical genomics approach to identify QTLs associated with variation in stem cell potential.
Genomics Institute of the Novartis Research Foundation, San Diego, Ca. July 2002.
-Stem cells; potential, selection and plasticity. 27th International Symposium on Blood
Transfusion: “Cellular engineering and cellular therapies”. Groningen, the Netherlands, October
9-11 2002.
-In vitro generation of stem cells. Boerhave Award Lecture, Leiden University Medical Center,
Leiden, Netherlands, September 2002.
2003
-The role of Fibroblast Growth Factors in Hematopoietic Stem Cell biology. January 27, 2003.
CLB Amsterdam.
-Ex vivo stem cell expansion. February 4, 2003. Dept. Stem Cell Biology, University of Lund,
Sweden.
-A genetical genomics approach to identify transcriptional pathways in hematopoietic stem cells.
The first Netherlands System Biology Meeting: Emerging System Biology, March 6 and 7, 2003,
Hotel Zuiderduin, Egmond aan Zee, Netherlands
-Stamcellen: mogelijkheden en onmogelijkheden. Lezing voor Retina Patientenvereniging
Nederland, 15 Maart 2003. Oosterpoort Groningen.
-Ex vivo expansion of hematopoietic stem cells. Terry Fox Cancer Center, Vancouver, BC
Canada. April 7, 2003.
-In vitro hematopoietic stem cell expansion by fibroblast growth factors. Amgen Inc. Thousand
Oaks, Ca. September 15, 2003.
-Stem Cells; Selfrenewing or Aging? Annual Meeting of the German Society of Gerontology,
Hamburg, September 25, 2003.
-De wondere wereld van de stamcel’, Cursus Cytologie en Histologie van Bloed en Beenmerg,
klinische vervolgcursus. AZG Groningen, 25 september 2003.
-Systems Biology: When 1 + 1  2. Future Biology Congress. Biological Center, Haren. October
1, 2003.
-Expansion of hematopoietic stem cells by fibroblast growth factors. Molecular Haemopoiesis 6.
Organizers Tony Green and Doug Higgs, London, October 2, 2003.
-Klinische toepassingen van stamcellen. Voordracht Compagnonsdagen Nij Smellinghe
Ziekenhuis Drachten. Ameland 24 en 31-oktober 2003.
16
2004
-Aging of Hematopoietic stem cells. January 7, 2004. Invitation by Ulf Rapp & Albrecht
Mueller. University of Wurzburg, Germany.
-Uncovering regulatory pathways affecting hematopoietic stem cell function using ‘genetical
genomics’ April 23, 2004. 9th CDB Meeting, Invitation by Shin-Ichi Nishikawa and Timm
Schroeder, RIKEN Center for Developmental Biology, Kobe, Japan.
-Uncovering regulatory pathways affecting hematopoietic stem cell function. May 1, 2004.
Functional Genomics of Aging meeting. Heraklion, Crete, Greece.
-Ex vivo expansion of hematopoietic stem cells. May 17. Invitation by Tilman Borggrefe,
University of Ulm, Germany.
-In vitro generation of hematopoietic stem cells. Angiogenesis and Tissue Engineering seminar
organized by Dutch Society for Cell Biology and BD Biosciences. June 1, Eindhoven, the
Netherlands.
-A genetic analysis of the stem cell transcriptome. 14th Hemoglobin Switching Meeting,
Invitation by Doug Higgs and George Stamatoyannopoulos. Sept. 10-14, 2004 , Orcas Island,
WA, USA
-Culturing Hematopoietic stem cells with Fibroblast Growth Factors. Invitation by Twan de
Vries, Leiden Center for Stem Cell Therapeutics, Leiden December 1, 2004.
-Genetic analysis of natural variation of gene expression in hematopoietic stem cells. Invitation
by Dr. Rob Williams, University of Tennessee, Memphis, TN, USA. December 2, 2004
-Stem cells in drug delivery and drug targeting. Workshop Advanced Drug Delivery/Drug
Targeting, Nederlandse Vereniging voor Farmaceutische Wetenschappen. Leiden University,
December 15, 2004.
2005
-Mapping gene networks in stem cells. Eurythron start-up meeting, Department Cell Biology,
Erasmus MC Rotterdam. January 20, 2005.
-The effect of age on stem cell function. 3rd International Symposium on the clinical Use of
Cellular Products. March 18, 2005, Regensburg, Germany. Invitation by Andreas Mackensen.
-Gene networks in hematopoietic stem cells. Dept. Gene and Cell Medicine, Mt. Sinai School of
Medicine, New York City, NY. April 26, 2005. Invitation by Hans Snoeck.
-Genetical Genomics to Identify gene networks in Hematopoietic Stem Cells. National Institutes
of Health RFA stem cell grantee meeting. April 28, 2005. Bethesda, MD.
-Genetical Genomics. 2nd International symposium on Networks in Bioinformatics. University of
Amsterdam, May 23, Amsterdam, the Netherlands.
-Molecular Mechanism of Stem Cell Development. Stem Cell Math Lab 2005. 2nd International
workshop on concepts and mathematical model of tissue stem cell organization. May 27, 2005.
Leipzig, Germany. Invitation by Markus Loeffler.
-Stem cell therapy to restore salivary gland function after irradiation. Amgen Inc. Thousand
Oaks, CA. August 4, 2005.
-A genetical genomics analysis to search genes that prevent stem cell aging. Salk Institute, San
Diego, CA. August 11, 2005. Invitation by Inder Verma and Sebo Withoff.
17
- A genetical genomics analysis to search genes that prevent stem cell aging.Genomics Institute
of the Novartis Research Foundation, San Diego, CA. August 12, 2005. Invitation by Mike
Cooke.
-The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion. Sidney Kimmel
Cancer Center, San Diego, CA. August 17, 2005. Invitation by Christa Muller-Sieburg.
-Gene networks in hematopoietic stem cells, Eurython EU FP6 meeting, Rome, Italy, September
22, 2005.
- Stamcellen: adult of embryonaal, invriezen of weggooien, fictie of werkelijkheid? October 18,
2005. Isala Klinieken Zwolle.
-Gene networks in hematopoietic stem cells, November 8, 2005. Dutch Cancer Institute,
Amsterdam. Invitation by Bas van Steensel
-Aging of Hematopoietic Stem Cells. December 2, 2005. Annual Meeting of the Austrian Society
for Immunology and Allergology, Graz, Austria.
2006
-Aging of hematopoietic stem cells: mechanisms and molecules. 3rd Functional Genomics of
Aging Meeting, Palermo, Italy March 29, 2006. Invitation by Jan Vijg
-Genetical Genomics in hematopoietic stem cells. Seminar in Graduate Program in Molecular
Medicine at the University of Maryland School of Medicine, Baltimore, MD. April 17, 2006.
Invitation by Ferenc Livak.
-A chromosome 18 QTL regulating chromatin remodelling genes and hematopoietic stem cell
pool size. 5th Annual meeting of the Complex Trait Consortium, May 6-10, Chapel Hill, NC.
- The Polycomb Group Gene Ezh2 Prevents Hematopoietic Stem Cell Exhaustion. Annual
Meeting of Dutch Platform for Tissue Engineering, May 15, 2006, Noordwijkerhout, the
Netherlands.
-Over genen en stamcellen, en de droom van een langlevend genoom. Jaarlijkse Meeting
Nederlandse Vereniging van Pharmacie Studenten, 25 Mei. Zevenaar.
-Route 28 Meeting on “Adult neurogenesis, stem cells, and aging”. Frauenchiemsee, Germany,
September 2, 2006. Invitation by Gerd Kempermann.
-International Symposium on Hematopoietic Stem Cells 6, Tuebingen, Germany, September 14,
2006. Invitation by Lothar Kanz
-The Polycomb group gene Ezh2 prevents stem cell exhaustion. International society for
Experimental Hematology Meeting Minneapolis, MN. September 29, 2006. Invitation by
Catherine Verfaillie.
-Basic Therapeutics of Stem Cells. 25th Annual Meeting of ESTRO, Leipzig, Germany, October
8, 2006.
-Aging of Hematopoietic stem cells, molecules and mechanisms. Institute for Biomedical Aging
Research, Innsbruck, Austria. November 7, 2006. Invitation by Guenther Lepperdinger.
-Hematopoietic stem cell aging, Keynote speaker Annual Meeting Dutch Society for
Immunology, Noorwijkerhout, the Netherlands, December 8, 2006.
2007
-Aging of hematopoietic stem cells; a genetic approach towards mechanisms and molecules.
Department of Hematology, Erasmus MC, Rotterdam. January 15. Invitation by Ivo Touw.
18
- Aging of hematopoietic stem cells; a genetical genomics approach towards mechanisms and
molecules Roslin Institute, Roslin, Scotland. February 8. Invitation by Chris Haley.
-Stamcellen en hoe zit dat met ethiek? Groninger Studentenpastoraat, Groningen. March 12
2007.
-Aging of hematopoietic stem cells, a genetic and genomic approach. Weatherall Institute for
Molecular Medicine, Oxford, UK. March 6, 2007. Invitation by Tariq Enver.
-Aging of hematopoietic stem cells. Academic Medical Center Amsterdam, April 18, 2007.
Invitation by Steven Pals.
-Genetical Genomics; a powerful approach to uncover complex gene networks. Annual Meeting
of the Dutch Society of Human Genetics, Veldhoven. April 20, 2007. Invitation by Robert
Hofstra.
-Aging of hematopoietic stem cells, molecules and mechanisms. Biotech Research and
Innovation Centre, Copenhagen, Denmark. April 8, 2007. Invitation by Adrian Bracken/Kristian
Helin.
-Aging of hematopoietic stem cells. Annual meeting of the European Hematology Association,
Vienna, Austria, June 10, 2007
-Genome-wide identification of master regulators of transcriptional networks during
hematopoietic development. September 29, 2007. 36th Annual Meeting of the International
Society for Experimental Hematology, Hamburg, Germany.
-Genome-wide identification of regulators of transcriptional networks during hematopoietic
development. October 9, 2007. Genomics Institute of the Novartis Research Foundation, San
Diego, CA.
-Identification of gene networks in hematopoietic cell development. Minisymposium Research
School in Stem Cell Biology, Lund University, Lund, Sweden, October 26, 2007
-Aging of hematopoietic stem cells. BioMedical Primate Research Center Rijswijk, the
Netherlands. November 6, 2007.
-Gene Networks in Hematopoietic Stem Cells. Frontiers in Science lecture. Deaprtment of Cell
Biology, Erasmus University Rotterdam. November 14, 2007. Invitation Wouter de Laat.
-Stamcellen, mogelijkheden en onmogelijkheden. Groninger Ingenieurs Vereninging. 6
November 2007.
2008
-A genetic approach to understand hematopoietic stem cell aging. Nijmegen Centre for
Molecular Life Sciences Post-doc retreat, Vught, the Netherlands. January 21, 2008.
-Gene networks during hematopoietic development. BSIK Stem Cells for Development and
Disease Meeting Rotterdam. January 29, 2008
-Hematopoietic stem cell aging; models and mechanisms. Annual Meeting Stichting
Kinderoncologie Nederland, Utrecht, the Netherlands. February 7, 2008.
-Expansion of Hematopoietic Stem Cells with FGFs. Gordon Conference on Fibroblast Growth
Factors in Development, Il Ciocco, Barga, Italy. March 6, 2008
-Genetical Genomics. EuroSystem meeting Les Diablerets, Switzerland. March 11-12, 2008
-Combining gene expression with genetic linkage. Keynote lecture at the 2008
Neurofibromatosis Conference Naples, Florida. June 8, 2008.
19
-Genome-wide identification of regulators of transcriptional networks during hematopoietic stem
cell development, 2nd International Congress on Stem Cells and Tissue Formation, July 8, 2008,
Dresden, Germany
-A genetic analysis of variation in gene expression during hematopoietic development. 37th
annula meetin of the International Society for Experimental Hematology, Boston, MA, July 11,
2008.
-Genome-wide analysis of gene networks during hematopoietic development. 9th Royan
International Twin Congress, Teheran, Iran. August 28, 2008
-Aging of hematopoietic stem cells. 9th Royan International Twin Congress, Teheran, Iran.
August 28, 2008
-Appearance in “Dat kan beter”, Dutch national TV program (VPRO) on human longevity.
September 10, 2008.
-Appearance in “Tumult”, Debating Center in Utrecht, organized by the Centre for Society and
Genomics Radboud University Nijmegen, on human longevity. October 29, 2008.
-Appearance in “de Praktijk”, AVRO Radio1, Dutch National Radio on use of adult stem cells.
December 1, 2008.
-Appearance in Hoe?Zo!, TELEAC Radio 5, Dutch National Radio on use of adult stem cells.
December 15, 2008.
2009
-Aging of stem cells. Croucher Foundation Advanced Study Institute on Aging and Longevity.
University of Hong Kong, Hong Kong. February 12, 2009. Invitation by Zhong Jun Zhou.
-Appearance on OOG-TV, local TV station, on Aging Research, March 27, 2009.
-BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells.
Eurythron meeting, Lisbon, April 1, 2009.
-Genetic and epigenetic control of hematopoietic stem cell aging, Symposium Regenerative
Medicine, University Medical Center Utrecht, Utrecht, April 2, 2009.
-Exploiting genetic variation to uncover transcriptional networks in hematopoiesis. ESA-EHA
Scientific Workshop Leukemic and Cancer Stem Cells, Cannes, France, April 5, 2009.
-Aging of hematopoietic stem cells. Symposium on Molecular Mechanisms of Adult stem cell
aging, Reisenburg, Germany, May 23 2009.
-Mapping mRNA expression QTLs in hematopoietic stem cells and their progeny. European
Society for Human Genetics, Vienna, Austria. May 25, 2009.
-Advances in stem cell research, Stem Cells, Systems and Synthetic Biology, EMBO Course,
Cambridge, UK. June 16, 2009.
-Exploiting genetic and epigenetic variability to understand hematopoietic stem cells. Cambridge
Institute for Medical Research, Cambridge, UK. June 17, 2009.
-Gene networks in Hematopoietic cell development. Int.Society for Stem Cell Research 2009.
Barcelona, Spain, July 10, 2009.
-Mapping transcriptional networks in hematopoietic stem cells. Gordon Research Conference,
Les Diablerets, Switzerland, September 14, 2009.
-Stem cells and aging. EuroSystems Summer School Stem Cells and Regenerative Medicine.
Hydra, Greece, September 24, 2009.
20
-Identification of gene networks in hematopoietic stem cells. International Graduate School in
Molecular Medicine, Ulm. October 1-2, 2009.
-Kenniscafe Studium Generale Groningen “Gezond Oud. October 8, 2009
-Leukemie. Gastcollege voor Publieksakademie Dagblad vh Noorden/UMCG November 9, 2009.
2010
-Unravelling the genetics underlying hematopoietic stem cell selfrenewal and aging. Hubrecht
Institute for Developmental Biology, Utrecht, the Netherlands. March 4, 2010.
- Unravelling the genetics underlying hematopoietic stem cell selfrenewal and aging. Wellcome
Trust Centre for Cancer Research, Cambridge, UK. March 5, 2010.
-Aging of hematopoietic stem cells; a genetic program or random noise? The biology of aging:
mechanisms and intervention. 61. Mosbacher Kolloquium. Mosbach, Germany, April 10, 2010.
-Symposium Filosofie en Wetenschap. St.Ludgercollege Doetinchem, 16 april 2010.
-Aging of Hematopoietic Stem Cells. Stem Cell Institute University of Leuven, Leuven Belgium.
April 26, 2010.
-Stad en Toga (samenwerkingsverband Hanzehogeschool, RuG, gemeente Groningen): De Kunst
van het Ouder Worden. 10 mei 2010. Groningen.
-Over het invriezen van navelstrengstamcellen. AVRO Radio 1, de Praktijk. 10 mei 2010
-Age and fate of hematopoietic stem cells. Hemato-Linne Symposium, Lund, Sweden. May 15,
2010.
-Gene regulatory networks. Dutch Cancer Institute Amsterdam. June 15, 2010.
-Aging of hematopoietic stem cells; a genetic program or random noise?. The First Annual Mayo
Clinic Robert and Arlene Kogod Center on Aging Conference. Red Wing, Minnesota. June 1720, 2010.
-Aging of hematopoietic stem cells. Netherlands Institute for Regenerative Medicine, Utrecht, the
Netherlands. June 21, 2010.
-Aging of hematopoietic stem cells. Gordon Conference on the Biology of Aging. August 23,
2010. Les Diablerets, Switzerland.
-Radio appearance Dutch National Radio PREMTime ( http://premtime.ntr.nl/). September 27,
2010 on healthy aging.
-A microRNA cluster that modulates hematopoietic stem cell pool size. Netherlands Institute for
Regenerative Medicine, Amsterdam October 14, 2010.
-Aging of Hematopoietic stem cells. International Forum on Stem Cells, Tianjin, China,
November 12, 2010.
2011
-Keynote speech “Gen-ethische verkenningen”. Symposium over Biotechnologie. Telders
Stichting. Den Haag, 28 January 2011.
-Developing next generation sequencing technologies to track leukemic stem cell clones. Cancer
Stem Cells: Deciphering signalling pathways. February 17, 2011. Paris.
-Age-related changes in murine hematopoiesis is mediated by highly variable acquisition of
functionally defective hematopoietic stem cells. Cologne Spring Meeting, March 10., 2011
-Aging of hematopoietic stem cells. Leibnitz Institute for Aging Research, Jena, Germany. March
17, 2011.
-Symposium Filosofie en Wetenschap. St.Ludgercollege Doetinchem, 1 april 2011
21
-Aging of Hematopoietic Stem Cells. 3rd Else Kroener-Fresenius Symposium on Molecular
Mechanisms of Stem Cell Aging, Reisensburg Castle, Guenzburg, Germany, May 22, 2011.
-Regeneratie, Reprogrammering en Rejuvenatie. Lezing HanzeHogeschool Groningen, May 26,
2011.
-Educational Program of European Hematology Association: The power of diversity:
hematopoietic stem cell heterogeneity and its clinical relevance. June 10, 2011, London.
-Regulation of selfrenewal and differentiation of HSC by Polycomb group genes. Recent
Developments in Stem Cell Research, Netherlands Institute for Regenerative Medicine,
September 20, 2011, Amsterdam.
-Master Class “Towards cure for leukemia”, NCMLS Nijmegen, The role of Cbx proteins in
hematopoietic stem cell selfrenewal. October 27, 2011, Nijmegen, the Netherlands
- Educational Program of European Hematology Association: The power of diversity:
hematopoietic stem cell heterogeneity and its clinical relevance. November 5, 2011, Bangalore,
India.
-Keynote Address Annual Meeting of the Deutsche Gesellschaft fuer Alternforschung: Aging of
hematopoietic stem cells, Reisenburg, Germany, December 2, 2011.
-The role of Polycomb group genes in regulating hematopoietic stem cells. University of Ulm,
Ulm, Germany, December 1, 2011
-
22
ONDERWIJS
2000:
2001:
2002:
2003:
2004:
2005:
Mentor 1e jaars geneeskundestudenten
Participatie Medische Biologie Cursus “Moleculaire Achtergrond van Ziekten”
Stagiaires Medische Biologie en HLO.
Mentor 1e jaars geneeskundestudenten
Participatie Junior Scientific Masterclass
Participatie Medische Biologie Cursus “Moleculaire Achtergrond van Ziekten”
Stagiaires Medische Biologie en HLO.
Hoorcollege “Stamcellen” Trimester 1.1
Tutor Trimester 2.3
Participatie Medische Biologie Cursus “Moleculaire Achtergrond van Ziekten”
Participatie Junior Scientific Masterclass
Organisatie 8 Hematology/Oncology Seminars/AIO workshops
Begeleiding Wetenschappelijke Stage 2 geneeskunde studenten
Stagiaires Medische Biologie en HLO.
Tutor Trimester 2.3
Organisatie 10 Hematology/Oncology Seminars/AIO workshops
Stagiaires HLO (3x).
TopMaster MPDI Week coordinator
Begeleider Wetenschappelijke stage AM Meppelink (3e jaars GNK), R. de Vries
(1e jaars GNK)
Participatie Medische Biologie Cursus “Moleculaire Celbiologie”
‘De wondere wereld van de stamcel’, Cursus Cytologie en Histologie van Bloed
en Beenmerg, Klinische vervolgcursus. AZG Groningen, 25 september 2003.
Klinische toepassingen van stamcellen. Voordracht Compagnonsdagen Nij
Smellinghe Ziekenhuis Drachten. Ameland 24 en 31-oktober 2003.
Caput Colleges Biochemie “Topics in Eukaryotic Cell Biology” 16 and 18 maart
(2 x 2 uur).
Junior Scientific Masterclass Lunch college
Tutor Trimester 2.3 en 3.1
Organisatie 9 Hematology/Oncology Seminars/AIO workshops
TopMaster MPDI Week coordinator
Deelnemer Cursus “Training the Trainers” georganiseerd door het Wenckebach
Instituut
Stagiaires HLO (Sita Houwer, Danielle Kruyswijk, Aletta Boer, Richard de Vries,
Eelo Gitz)
Begeleider Wetenschappelijke stage AM Meppelink, W Hofstra (3e jaars GNK),
R. de Vries (1e jaars GNK)
Doktoraalstudentent Biologie (Lisette Soolsma, Jolanda Overweel), TopMaster
MPDI (Alice Gerrits, Anil Rana). Scriptiebegeleiding Susanne Kooistra.
Organisatie 9 Hematology/Oncology Seminars/AIO workshops.
Stagiaires HLO (Alexandra Kleinstra)
23
Begeleider Wetenschappelijke stage (3e jaars GNK).
Doktoraalstudentent Biochemie (Anne Meinema)
TopMaster MPDI Week coordinator
Mentor Geneeskunde Trimester 1.2
Scriptiebegeleiding Erhard de Vries.
Blokcoordinator specialisatie cursus Medische Celbiologie
2006:
College Stamcellen (Masteropleiding BCN)
Stagiaires HLO (Emiel Polder)
TopMaster MPDI Week coordinator
Doktoraalstudenten Joanna Kaplon, Beate Surmacz, Michalina Janiszeliska,
Marcel Otten.
Organisatie 7 Hematology/Oncology Seminars/AIO workshops
Blokcoordinator specialisatie cursus Medische Celbiologie
Coordinator BBB Junior Scientific Masterclass lezingen
Jurylid 13e International Student Congress of Medical Sciences, 14-17 juni 2006,
Groningen
2007:
BBB JSM Lecture 2e jaars geneeskunde
Organisatie 7 Hematology/Oncology Seminars/AIO workshops
Blokcoordinator specialisatie cursus Medische Celbiologie
Coordinator BBB Junior Scientific Masterclass lezingen
Mentor 1e jaars GNK studenten Trimester 1.2
TopMaster MPDI Week coordinator
2008:
BBB JSM Lecture 2e jaars geneeskunde
Organisatie 6 Hematology/Oncology Seminars/AIO workshops
Blokcoordinator specialisatie cursus Medische Celbiologie
Coordinator BBB Junior Scientific Masterclass lezingen
Mentor 1e jaars GNK studenten Trimester 1.2
TopMaster MPDI Week coordinator
2009:
Organisatie 6 Molecular Medicine Seminars/AIO workshops
Blokcoordinator specialisatie cursus Medische Celbiologie 2e jaarscursus
Blokcoordinator specialisatie cursus Medische Celbiologie 3e jaarscursus
Coordinator BBB Junior Scientific Masterclass lezingen
Mentor 1e jaars GNK studenten Trimester 1.2
TopMaster MPDI Week coordinator
JSM Schiermonnikoogweek Cursusleider
Gastcollege Cancer Center Amsterdam (Vumc): Epigenetika en stamcellen 14-042009
Gastcollege Hogeschool Leeuwarden: Stamcellen, veroudering en regeneratie. 27
maart 2009.
Lecturing in EuroSystems Summer School Stem Cells and Regenerative
Medicine. Hydra, Greece, September 24, 2009.
24
Lecturing in International Graduate School in Molecular Medicine, Ulm. October
1-2, 2009.
2010:
PhD course Hubrecht Institute Utrecht: Masterclass “Gene networks in stem
cells”. January 13, 2010.
Masterclass Leiden University Medical Centrer. “Aging of hematopoietic stem
cells, March 17. 2010.
Gastcollege Hanze Hogeschool Groningen. Stamcelbiologie. March 19, 2010.
Blokcoordinator specialisatie cursus Medische Celbiologie 2e jaarscursus
Blokcoordinator specialisatie cursus Medische Celbiologie 3e jaarscursus
Coordinator BBB Junior Scientific Masterclass lezingen
Mentor 1e jaars GNK studenten Trimester 1.2
PhD course Netherlands Cancer Institute Amsterdam: Masterclass “Gene
Networks”. June 16, 2010.
PhD Masterclass course Regenerative Medicine, University Medical Center
Utrecht, May 20, 2010.
2011:
Guest Professor Honours Class 2010-2011 University of Leiden: Biology of
blood-forming stem cells.
Blokcoordinator specialisatie cursus Medische Celbiologie 2e jaarscursus
Blokcoordinator specialisatie cursus Medische Celbiologie 3e jaarscursus
Coordinator BBB Junior Scientific Masterclass lezingen
Mentor 1e jaars GNK studenten Trimester 1.2
Begeleider Proefielwerkstuk 6 Gymnasiumscholieren Kim Drent/Amber de Haan
PhD course Hubrecht Institute Utrecht: Masterclass “Gene networks in stem
cells”. April 12, 2011.
Seminar Honours College RijksUniversiteit Groningen . Hematopoietic stem cell
aging. May 26, 2011.
Guest Professor Master Class October 27, 2011 Towards Cure for Leukemia,
University of Nijmegen. Cbx proteins regulate stem cell behaviour.
4 Lectures for 1st year Medical Students, University of Groningen on stem cells
and aging.
Lecture for 3rd year Biology Students Molecular Biology of Aging course.
25
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