BIOGRAPHICAL SKETCH
NAME
Chetan Parkash Hans
COMMONS USER NAME
Hans CP, Hans C,
POSITION TITLE
Post Doc Researcher
EDUCATION/TRAINING
AND LOCATION
, such asINSTITUTION
nursing, and include
postdoctoral training.)DEGREE
LSU Health Science Center
Mississippi State University, MS 39759
Post Doc
Post Doc
YEAR(s)
2005-date
2003-2005
Panjab University, Chandigarh, India
Ph.D.
1998-2002
Institute of Chemists, Calcutta, India
M.Sc. (Gold
medalist))
1994
FIELD OF STUDY
Role of PARP in
atherosclerosis
Growth Hormone
induced Insulin
Resistance
Correlation of
Magnesium and
Oxidative Stress in
Diabetes Mellitus
Biochemistry, Applied
Chemistry
Special Recognitions
 Gold medal for standing first in MSc.
 Best poster at Research foundation day (2007), LSUHSC. New Orleans LA.
 Third best poster at Research Foundation day (2008) LSUHSC. New Orleans LA.
Title of PhD thesis

Inter Relationship of Magnesium and Antioxidant Potential in Diabetes Mellitus under the supervision
of Prof. DD Bansal, Panjab University, Chandigarh, India.
SUMMARY
Objective of the PhD study was to establish correlation between magnesium deficiency and oxidative
stress in diabetes since magnesium deficiency has been independently proposed as a state of increased
oxidative stress. The study found increased oxidative stress, dyslipidemia, ionic alterations and impairment in
the ATPase activities in blood/various organs in magnesium deficiency as well as diabetes in experimental
rats and most of these biochemical alterations were reversed by magnesium supplementation in these rats.
Strong correlation was also observed between magnesium depletion and oxidative stress in diabetic patients.
In brief, these findings suggest that magnesium depletion may be the causative factor partly responsible for
oxidative stress, dyslipidemia, ionic alterations or impaired ATPase activity in diabetes.
8
Chetan P Hans PhD
PROFESSIONAL EXPERIENCE


2003-2005 (July) Worked as Post Doc Associate in the Department of Animal and Dairy Sciences,
Mississippi State University, MS 39762.
2005 (Aug)-date Working as Post Doc Researcher in Dept of Pharmacology, LSUHSC, New
Orleans, LA.
PUBLICATIONS

Hans CP, Zerfaoui M, Naura A, Troxclair D, Strong JP, Matrougui K, Boulares H. Thieno[2,3c]isoquinolin-5-one (TIQ-A), a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic
plaque regression in high fat diet-fed ApoE-deficient mice: effects on inflammatory markers and lipid
content. Journal of Pharmacology and Experimental Therapeutics. 2009:jpet.108.145938.

Hans Chetan P., Zerfaoui M, Naura AS, Catling A, Boulares AH. (2080). Differential effects of PARP
inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.
Cardiovasc Res 78:429-439.
Commentary in Levi M, Stroes E. Targeting the prevention of plaque rupture as a new strategy for
prevention of acute arterial cardiovascular events. Cardiovasc Res 2008;78:407-408.

*Karine Oumouna-Benachour, *Chetan P Hans, Yasuhiro Suzuki, Amarjit Naura, Rahul Datta, Souad
Belmadani, Cooper Woods, and Hamid Boulares (2007). PARP-1 Inhibition Reduces Atherosclerotic
Plaque Size and Promotes Factors of Plaque Stability in ApoE-Deficient Mice: Effects on Macrophage
Recruitment, NF-kappaB Nuclear Translocation, and Foam Cell Death. Circulation 115(18):2442-50.
*These authors contributed equally to this work

Amarjit S. Naura, Rahul Datta, , Chetan P. Hans, , Mourad Zerfaoui, , Bashir
M. Rezk, , Youssef Errami, , Mustapha Oumouna, , Khalid Matrougui,
and A. Hamid Boulares. Reciprocal regulation of iNOS and PARP-1 during allergen-induced
eosinophilia. Eur Respir J. 2008 Oct 1.

Mourad Zerfaoui, Yasuhiro Suzuki, Amarjit S. Naura, Chetan P. Hans, Charles Nichols, and A.
Hamid Boulares. (2008). Nuclear translocation of p65 NF-kB is sufficient for vcam-1, but not icam-1,
expression in TNF-stimulated smooth muscle cells: Differential requirement for PARP-1 expression
and interaction. Cell Signal186-94.

Naura AS, Hans CP, Zerfaoui M, You D, Cormier SA, Oumouna M, Boulares, A. H (2008). Postallergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for
treatment of allergic airway inflammation. Clin Exp Allergy;38:839-846.

Oumouna-Benachour Karine, Mustapha Oumouna, Mourad Zerfaoui, Chetan P Hans, Kenneth
Fallon and Hamid Boulares Intrinsic resistance to apoptosis and elevated rates of proliferation of
colon epithelial cells are potential determining factors in the susceptibility of the a/j mouse strain to
dimethylhydrazine-induced colon tumorigenesis. 2007. Molecular Carcinogenesis. 46 (12): 993-1002.
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PhD
Chetan P Hans

Mustapha O, Datta R, Oumouna-Benachour K, Suzuki Y, Hans C, Matthews K, Fallon K, Boulares
H.(2006). Poly(ADP-ribose) Polymerase-1 Inhibition Prevents Eosinophil Recruitment by Modulating
Th2 Cytokines in a Murine Model of Allergic Airway Inflammation: A Potential Specific Effect on IL-5.
J Immunol. Nov 1; 177(9):6489-96.

Hans CP, Chaudhary DP, Bansal DD (2003). Effect of magnesium supplementation on oxidative
stress in diabetic rats. Magnes Res 16; 1:13-19.

Hans CP, Sialy R, Bansal DD (2002). Hypomagnesaemia in diabetic patients: Correlation with
oxidative stress. International J of Diabetes in Developing Countries 22:122-131.

Hans CP, Sialy R, Bansal DD (2002). Magnesium deficiency and diabetes mellitus. A review article.
Current Science 85: 1456-1463.

Hans CP, Chaudhary DP, Bansal DD (2002). Magnesium deficiency increases oxidative stress in
rats. Ind. J. Exp. Biol; 40: 1275-1279.

Bansal DD, Hans CP (1999). A shift in the control of development of diabetic complications. Indian J
Endocrinol Metabolism; vol3, No. 1: 28-32.

Bansal DD, Hans CP (1999). Trends in diabetes research. The Biotech Bulletin, Panjab University,
Chandigarh; 8: 119-128.
Manuscripts submitted (under revision).

Hans Chetan. P, H. M. Wilson, T. R. Smith (2008). Growth Hormone-induced insulin resistance:
Impact on localization and activation of the insulin receptor. (Submitted after revision).
SEMINARS/PRESENTATIONS
 “Dyslipidemia-induced Cardiac and Vascular Dysfunctions: Protective effects by PARP-1
inhibition.”Pharmacology Conference Room 5252, LSUHSC, New Orleans, LA, March 2008.
 “Differential Roles of PARP-1 in oxidants and cytokine-mediated cell death in an in vitro model
mimicking atherosclerotic plaque dynamics.” Pharmacology Conference Room 5252, LSUHSC, New
Orleans, LA, April 2007.
 “Multifaceted Functions of PARP-1 in Animal Models and Cell Culture Systems of Atherosclerosis.”
Conference Room 5252, LSUHSC, New Orleans, LA, June 2006.
PAPERS PRESENTED

Chetan P Hans, Mourad Zerfaoui, Amarjit Naura, Dana Troxclair, Jack P Strong, and Hamid
Boulares. Abstract 1685: Thieno[2,3-c]isoquinolin-5-one (TIQ-A), a Potent Poly(ADP-ribose)
Polymerase Inhibitor, Promotes Atherosclerotic Plaque Regression in High Fat Diet-fed ApoEdeficient Mice: Effects on Inflammatory Markers and Lipid Content. Circulation, Oct 2008; 118:
S_369.
10
PhD
Chetan P Hans
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Chetan P Hans, Yumei Feng, Amarjit Naura, Mourad Zerfaoui, Dana Troxclair, Khalid Matrougui, Eric
Lazartigues, and Hamid Boulares. Abstract 311: Poly(ADP-ribose) Polymerase-1 Inhibition Prevents
High Fat Diet-induced Cardiac Hypertrophy by Modulating Matrix-destabilizing Proteases and
Oxidative Stress. Circulation, Oct 2008; 118: S_282.
Chetan P Hans, K. Oumouna-Benachour, Y. Suzuki, A. Naura, C.T. Woods, and H. Boulares. 2007.
Differential Roles of PARP-1 in oxidants-mediated cell death in an in vitro model mimicking
atherosclerotic plaque dynamics: implication in atherosclerosis. FASEB J. A9-576.6.
C.P. Hans, Y. Suzuki, A. Naura, M. Zerfaoui, A. Catling and A.H Boulares (2007). Differential roles of
poly(ADP-ribose) polymerase (PARP-1) in oxidant mediated cell death in vascular cells: implications
in atherosclerosis. Graduate school research day, LSU, New Orelans.
R.A. Reddix, C. Hans, H. Boulares and P.A. Lucchesi. Differential effects of aging on MCL-1 and
caspase 3 expression in murine small and large intestine. 2007. LSU Hlth. Sci. Ctr., New Orleans.
FASEB J. B155 729.6
Hamid Boulares Yasuhiro Suzuki, Amarjit Naura, Mustapha Oumouna, Rahul Datta, and Chetan
Hans. PARP-1 and iNOS relationship in allergen-induced lung inflammation: dependence of iNOS
expression on PARP-1 and its dispensability for eosinophil recruitment post-IL-5 production. 2007
Annual meeting of the American Association of Immunologists (Miami FL; May 2007).
Amarjit S Naura, Chetan Hans, Mourad Zerfaoui, Mustapha Oumouna, and Hamid A Boulares A.
post-allergen challenge inhibition of PARP prevents airway eosinophilia and reduces Th2 cytokines
and mucus production in animal model of asthma: a clinical potential in the treatment of asthma.
2007. Annual meeting of the American Association of Immunologists (Miami FL; May 2007).
Hans, C., Oumouna-Benachour, K., Suzuki, Y., Woods, T. and Boulares, H. 2006. PARP-1 inhibition,
pharmacologically or genetically, reduces plaque size and promotes factors of plaque stability in an
ApoE−/− mouse model of atherosclerosis. FASEB J LB484.
Boulares, H., Oumouna, M, Datta, R., Matthews, K, Oumouna-Benachour, K, Kenneth Fallon, Chetan
Hans, and Yasuhiro Suzuki. PARP-1 inhibition prevents eosinophil recruitment by modulating Th-2
cytokines in a murine model of asthma: a potential specific effect on IL-5. 2006 Annual meeting of the
American Association of Immunologists (Boston MA; May 2006).
Suzuki, Y, Hans, C, Oumouna-Benachour, K, Woods, C and Boulares, H. 2006. Differential role of
PARP-1 in p65 NF-B translocation into nuclei of primary aortic smooth muscle cells in response to
TNF, LPS or H2O2: Implication in atherosclerosis. FASEB J. LB 561
Hans, C.P., H.M. Wilson and T.R. Smith. 2005. Growth Hormone-induced insulin resistance: Impact
on localization and activation of the insulin receptor. FASEB J. LB95.
V Rattan, CP Hans, BS Verma and AS Bawa. Biochemical Evaluation of oxidative stress in patients
with renal stone disease. At Association of Clinical Biochemists of India (ACBI) 29th national
Conference 3rd-5th Feb 2003.
CP Hans and DD Bansal. Status of magnesium and its relation with oxidative stress in diabetic rats.
At Research Society for the Study of Diabetes in India (RSSDI) 30th annual Conference, 11th-13th
Oct. 2002.
V Rattan, CP Hans and DD Bansal. Oxidative stress in acute and chronic renal failure patients. At 9th
Asian-Pacific Congress of Clinical Biochemistry (APCCB), Feb 2002.
CP Hans, R Sialy and DD Bansal. Correlation of hypomagnesaemia and oxidative stress in diabetic
patients. At Endocrine Society of India (ESICON) 31st National Conference 9th -11th Dec 2001.
11
PhD
Chetan P Hans
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CP Hans, R Sialy and DD Bansal. Antioxidant status of magnesium deficient rats. At Society of
Biological Chemists (SBC, India) 68th annual meeting and symposium on current trends in Biology.
Dec 27th-29th, 1999.
CP Hans, R Sialy and DD Bansal. Effect of magnesium deficiency on free radical mediated
diseases. At third Panjab Science Congress, Dept of Biotechnology, Panjab University, Chandigarh.
1999.
RESEARCH GRANT
American Heart Association postdoctoral fellowship award (0825470E) July 2008. Role: Principal
Investigator. Title of Project: Regulation of TIMP-2 Expression by PARP-1 and its Implications in the
Pathogenesis of Atherosclerosis.
12
PhD
Chetan P Hans