Full list of supervisors ICES – Institute of Chemical & Engineering Sciences Surname Given Names Department Research Interests Email Contact Abdul Majeed Seayad Organic Chemistry abdul_seayad@ices.astar.edu.sg Adsool Vikrant Arun Organic Chemistry, Helios Aitipamula Srinivasulu ICES/CPS/Crystalliz ation Anbanandam Parthiban Polymer Ang Ee Lui MERL Balagurunatha n Balaji Scientist II Borgna Armando Heterogeneous Catalysis Bu Jie Process Science and Modelling Catalytic methods in organic synthesis, Green Chemistry, Homogeneous Catalysis Enantioselective organic synthesis Total synthesis of complex natural products Synthesis and exploration of novel bioisosteres Medicinal chemistry and chemical biology (synthesis of molecular probes for protein pull-down studies) Fragment-based drug discovery Pharmaceutical Crystallization, Cocrystallization, Polymorphism, Supramolecular Chemistry, Crystal Engineering. Solid-form development Functional Polymers, Polymers possessing functionalizable backbones, Controlled free radical and step growth polymerizations, Specialty polymers for coating applications, Polymers containing degradable backbones Engineering of microorganisms for the production of biobased chemicals. Development of consolidated bioprocess platform for the efficient utilization of biomass. Development of new computational and experimental approaches for synthetic biology and metabolic engineering applications. Metabolic Engineering Bioprocess Development Systems and Synthetic Biology Gas-to-Liquids (GTL), FischerTropsch, C1 chemistry; Environmental Catalysis (Air pollution control by catalytic oxidation, Catalysts for Clean Fuels); Molecular sieves; Metal Catalysts, Catalysts Deactivation and Regeneration; Nanostructured Materials: A Scale-up chemical reaction, safety study, design reactor system & vikrant_adsool@ices.a -star.edu.sg srinivasulu_aitipamula @ices.a-star.edu.sg a_parthiban@ices.astar.edu.sg ang_ee_lui@ices.astar.edu.sg balaji_balagurunathan @ices.a-star.edu.sg Armando_Borgna@ice s.a-star.edu.sg bu_jie@ices.astar.edu.sg Jan 2015 Full list of supervisors Burkett Brendan Adrian Organic Chemistry Carpenter Keith John Director's Office Chai Christina LL Organic Chemistry Chan Kok Ping Organic Chemistry Chang Jie Heterogeneous catalysis/ Testing Chen Anqi Organic Chemistry CHEN Luwei Heterogeneous Catalysis Chew Wee Process Science and Modelling process, Explore catalysts & new functionalized polymer for petrochem/pharmaceutical, Explore novel nanoporous/nanoparticle functional materials, Dvlpmt of on-line monitoring techniques (F Medicinal chemistry (antibiotics), pericyclic reactions, solid phase organic synthesis, total synthesis. brendan_burkett@ices .a-star.edu.sg keith_carpenter@ices. a-star.edu.sg Synthetic methodologies; synthesis of bioactive compounds, green chemistry, medicinal chemistry 1. Design and synthesis of natural product-based chemical probes for elucidating antiproliferative mechanisms in cancer cells2. Development of bioconjugation methodologies and identification of protein targets of small molecules in biological systems3. Synthesis of biologically interesting small molecules and peptides4. Development of novel methodologies in organic synthesis Catalytic technologies, including novel catalyst materials & catalytic processes development, kinetic modeling, and mechanism study, for bulk chemical production, particularly in renewable/green feedstock and processes Development of new synthetic methodologies and their applications in organic synthesis; Process development and medicinal chemistry; Synthesis of natural and unnatural compounds with biological activities and applications Heterogeneous catalysis and surface chemistry with focus on catalyst (advanced materials) development and reaction mechanism study for renewable energy and chemicals. 1. Infrared and Raman spectroscopy (applied to chemical imaging, process analytics, in situ process and reaction monitoring) 2. Bioimaging of cells and tissues for cellular studies and medical diagnosis 3. Process Analytical Technology Christina_Chai@ices.astar.edu.sg chan_kok_ping@ices.a -star.edu.sg chang_jie@ices.astar.edu.sg chen_anqi@ices.astar.edu.sg chen_luwei@ices.astar.edu.sg chew_wee@ices.astar.edu.sg Jan 2015 Full list of supervisors Chow Pui Shan, Ann Crystallisation and Particle Science Chow Yoong Sien, Yvonne Industrial Biotechnology David Wang Process Sciences and Modeling DONG YUANCAI Crystallisation & Particles Science Du Yonghua Heterogeneous catalysi Duong Anh Hung Organic Chemistry Gao Feng AREPAC Garland Marc Vincent Process Science and Modeling Guo Liangfeng PSM (laboratory device/ analytics interface programming, process analytics and chemometrics, continuous processing) 4. Multivariate Chemometrics/ Statistical Analysis (curve resolution, calibration, reaction kinetics and thermodynamics modeling) Control of crystal size and morphology Application of PAT in crystallisation processes Biocatalysis/Biotransformation for synthesis of fine chemicals/pharmaceuticals, Medium engineering & novel media for aqueous/non-aqueous, biocatalysis systems, Solubilisation of enzymes in non-aqueous media. Chemical process modeling, control, optimization, and monitoring (a) Solubilization and preformulation of water-insoluble drugs (b) Nanoparticulate formulations for intravenous, oral and pulmonary drug delivery (c) Feasibility studies of continuous and scalable production of nanoformulation (d) Polymer synthesis (e) Mixing and process intensification equipments X-ray absorption spectroscopy (XAS) and its applications in catalyst, energy, environment, life science, material science, etc.;Synchrotron radiation beamline automatic control;ScientificInstrumentation development related with XAS;XAS methodology study including experimental method and data analysis method Iron-catalyzed cross-coupling reactions, fluorination transformations and carbon dioxide fixation. Chemical reaction engineering, insitu spectroscopic study, BTEM application and DFT calculations Chemical kinetics, metal-mediated organic synthesis, spectroscopy, chemometrics, process analytics Chemometrics , Spectroscopy Ann_Chow@ices.astar.edu.sg yvonne_chow@ices.astar.edu.sg david_wang@ices.astar.edu.sg dong_yuancai@ices.astar.edu.sg du_yonghua@ices.astar.edu.sg duong_hung@ices.astar.edu.sg gao_feng@ices.astar.edu.sg marc_garland@ices.astar.edu.sg guo_liangfeng@ices.astar.edu.sg Jan 2015 Full list of supervisors Han Guangjun Crystallization He Tao Polymer group Heng Desmond Crystallization and Particle Science/Formulatio n Science Hermanto Martin Wijaya Huang Lin Nucleation phenomenon in solution; Crystal growth mechanism; Solution thermodynamics; Polymer nano-materials and applications han_guangjun@ices.astar.edu.sg desmond_heng@ices. a-star.edu.sg Crystallization and Particle Science / Crystallization Drug delivery, Respiratory medicine, Nanomedicine, Infectious diseases, Natural therapy, Particle technology, Novel particle and powder characterization methods, Aerosol devices • Process analytical technology development and implementation for crystallization Heterogeneous Catalysis • Process dynamic simulation, modeling, and control Heterogenized homogeneous catalysis: Hydroformylation Supported metal catalysis: Hydroformylation, C-C coupling, ethanol steam reforming Polymer Science/ Chemistry JANA SATYASAN KAR Polymer/ ICES Jayasree Seayad Organic Chemistry Johannes Charles William Organic Chemistry Jonnalagadda Sudhakar Process Science Modelling/Metaboli c Modelling Organometallic and organo catalysis for organic synthesis, Synthesis of biologically active molecules, C-1 chemistry, Green and sustainable chemistry • Total Synthesis of natural products • Enantioselective methodologies • Drug Discovery o Medicinal Chemistry o Development of novel and complex small molecular weight compounds as screening collections intended for pharmaceutical drug discovery o Development of new chemical technologies • Process Research Development of engineered biological strains and efficient bioprocesses for conversion of renewable resources to fuels & chemicals. system level modeling & analysis of metabolic networks, transcriptomic data analysis for identifying strategies for strain improvement and genetic engineering microbial strains for production of chemicals from he_tao@ices.astar.edu.sg martin_hermanto@ice s.a-star.edu.sg huang_lin@ices.astar.edu.sg satyasankar_jana@ice s.a-star.edu.sg jayasree_seayad@ices. a-star.edu.sg charles_johannes@ice s.a-star.edu.sg sudhakar_jonnalagadd a@ices.a-star.edu.sg Jan 2015 Full list of supervisors glucose. Kanaujia Parijat ICES Formulation of poorly soluble drug, hot melt extrusion, solubilization Parijat_Kanaujia@ices. a-star.edu.sg Khambadkone Ashwin Murlidhar Experimental Power Grid Center Distributed Power Generation, Microgrids, Power system Dynamics and control, Power electronic converter design and control, energy management, fuel cell based system, alternate energy systems, ashwinmk@epgc.astar.edu.sg Khoo Hsien Hui Process Science and Design (PEAD); Process Science and Modeling Kim Sanggu Crystallisation and particle Sciences Leung Yiu Chung Organic Chemistry control of electrical drives, automotive electronics and hybrid electric vehicles. Power management and digital control of power supplies. · Life cycle assessment · Carbon footprint · Waste management · Bio-based chemicals and fuels · Energy conversion · CO2 capture and sequestration · Global warming Novel formulations, particularly in designing and developing new nanostructured formulations for cosmetic and drug delivery systems, crystallization and nanoformulation technology which includes thermodynamic and kinetic properties of highly supersaturated submicron-sized particles of biomaterials such as amino acids, peptides and proteins and polymorphic solid phase transformation of pharmaceuticals, microemulsion crystallization and polymerization for nonosized particles and investigation of physiochemical properties and dehydration behaviors of pseudopolymorph drugs. Current works are focusing on phase behaviors, biological and physicochemical properties, and physical stability of biocompatible and biodegradable sugar-based surfactant microemulsions for potential topical delivery and solid nanoparticle preparation of cosmeceuticals and nutraceuticals Synthesis of natural products and bioactive compounds Drug development and design khoo_hsien_hui@ices. a-star.edu.sg Sanggu_Kim@ices.astar.edu.sg leung_yiu_chung@ices .a-star.edu.sg Jan 2015 Full list of supervisors Li Qingxin IB LIM Yee Hwee Organic Chemistry, ICES Liu Yan Heterogeneous Catalysis Liu Zhibin Industrial Biotechnology Luo Jizhong Heterogeneous Catalysis Ng Wai Kiong Crystallisation & Particle Sciences / Formulation Sciences Biomass conversion to chemicals; Fermentation Engineering; Enzyme Engineering; Bioremediation; Microbial enhanced oil recovery; High level expression and purification of membrane proteins; Protein structural and dynamic studies for ion channels; Protein folding and enzymatic kinetics. Fluorination, Catalysis, Natural Product Synthesis, Total Synthesis, Radiochemistry Li_qingxin@ices.astar.edu.sg Research interests include: • Applied Catalysis • Microporous & Mesoporous Materials • Nano Functional Materials • Carbon Materials • C1 Chemistry • Clean fuels • CO2 Capture and Utilization • Advanced in-situ characterization techniques development Isolation of useful microorganisms; Enzyme engineering; Metabolic engineering for producing chemicals Carbon credits and markets; CO2 capture and sequestration; Clean energy; H2/fuel cell technologies - Novel formulations for pharma & specialty chemical products liu_yan@ices.astar.edu.sg lim_yee_hwee@ices.astar.edu.sg liu_zhibin@ices.astar.edu.sg luo_jizhong@ices.astar.edu.sg ng_wai_kiong@ices.astar.edu.sg - Particle technology - Powder handling processes (e.g. pharmaceutical secondary manufacturing: milling, fluidisation, drying) NGUYEN Tuan Minh Neuros Lab/Organic Chemistry Division Poornachary Sendhil Kumar Ramalingam Balamurug an Crystallization and Particle Science/ Crystallization Science and modeling Organic Chemistry - Mass transfer technologies in oil & gas industry Methodology Development for Organic Synthesis; Molecular Switches; Photo-responsive Materials; Materials Chemistry Crystallization science, effects of impurities and additives on crystal growth, molecular modeling, submicron crystallization, colloids and surfaces. Homogeneous catalysis, Catalytic asymmetric transformation, Green and Sustainable Chemistry, Catalytic conversion of biomass to value nguyen_minh@ices.astar.edu.sg sendhil_poornachary @ices.a-star.edu.sg balamurugan_ramaling am@ices.a-star.edu.sg Jan 2015 Full list of supervisors added chemicals and Flow Chemistry Richard JeanAlexandre OC@Helios Schreyer Martin Karl Process Science & Modelling Shaik Mohamed Salim Process Science Modelling/Process Engineering & Design Sharratt Paul Process Science & Modelling Shen Shoucang Crystallisation and Particle Science Stubbs Ludger Paul Polymer Talukder Md. Mahabubu r Rahman Industrial Biotechnology Tam Kwok Wai, Eric Organic Chemistry Tan Beng Hee Reginald Crystallisation and Particle Science Teo Peili Chemistry department, NUS/ ICES (Neuros) Teoh Soo Khean PSM/INCOME Synthesis of dyes and light-emitting materials,Natural product and medicinal chemistry, Green chemistry X-Ray powder diffraction, crystal structure analysis, crystal chemistry, quantitative phase analysis, materials chemistry, inorganic solid state chemistry Process Safety, Hazard & Risk Assessment, Chemical Reaction Hazards, Dust Explosion, Safety Climate/Culture, Occupational Safety & Health jean_alexandre@ices.a -star.edu.sg 1. Process design and development, especially for low tonnage chemicals 2. Sustainable processing Nanostructured Materials; Functional Excipients, Drug Delivery paul_sharratt@ices.astar.edu.sg 1. Homogeneous catalysis 2. Olefin polymerization catalysts and copolymers 3. Catalyst immobilization and nanocomposites 4. Chemicals and polymers from renewable feedstock Enzymatic production of biodiesel and extraction of vitamin-E from vegetable oil Enzyme engineering: lipase modification, pretreatment and immobilization Medium engineering for biocatalysis in organic solvent Enzyme Kinetics Synthesis of designed compounds for biological evaluation, medicinal chemistry Crystallisation, micronisation, filtration, Process Analytical Technologies (PAT), supercritical fluids, solids characterisation. Organometallic chemistry, catalyst development for asymmetric synthesis, methodology development Process development and design, process innovation/intensification, continuous processing and sustainable development for chemicals and pharmaceuticals ludger_paul@ices.astar.edu.sg martin_schreyer@ices. a-star.edu.sg shaik_salim@ices.astar.edu.sg shen_shoucang@ices. a-star.edu.sg rahman_talukder@ice s.a-star.edu.sg eric_tam@ices.astar.edu.sg reginald_tan@ices.astar.edu.sg teo_peili@ices.astar.edu.sg teoh_soo_khean@ices .a-star.edu.sg Jan 2015 Full list of supervisors manufacture TIAN ZHIQUN Heterogeneous Catalysis/ Materials Synthesis Design and Synthesis of novel materials for heterogeneous catalysis application tian_zhiqun@ices.astar.edu.sg Van Herk Alexander Polymer Alexander_herk@ices. a-star.edu.sg Van Meurs Martin Polymer Emulsion polymerization, copolymerization, hybrid nanoparticles, polymerization kinetics, encapsulation and controlled release Homogeneous catalysis & organometallic chemistry martin_meurs@ices.astar.edu.sg Polymerisation and polymer characterisation Wang Bo ICES/Jurong Island WANG CUN Polymer William Anthony Organic Chemistry Wu Jinchuan Industrial Biotechnology YU ZAIQUN Crystallization and particle science Zhang Mingzi MERL Zhao Hua Industrial Biotechnology Zhong Ziyi Catalyst materials synthesis/Heteroge neous catalysis Conversion of biomass to chemicals Porous inorganic materials, noble metal nanoparticles, heterogeneous catalysis, sustainable and green process Organic and organometallic synthesis;Catalysis in the polymer formation;Single crystal X-ray diffraction for molecular structure determination;Conversion of biomass to value-added chemicals. Development of synthetic methodology, Natural product synthesis. Medicinal Chemistry, Drug discovery Enzyme modification/immobilization, Biotransformation in nonconventional media, Enzymecatalyzed asymmetric synthesis, Enzyme-based chiral separation, Bioprocess engineering, Plant cell culture. Application of process analytical technology in crystallization of pharmaceuticals Chemical Biology, Synthetic Biology, Metabolic Engineering, Natural Products Metabolic engineering of microorganisms for biofuels and biochemicals production Heterogeneous catalysis, Materials chemistry (synthesis of proporous materials, colloids, electrode materials, etc), Nanoscience and nanotechnology, Sonochemistry Wang_bo@ices.astar.edu.sg wang_cun@ices.astar.edu.sg anthony_william@ices .a-star.edu.sg wu_jinchuan@ices.astar.edu.sg yu_zaiqun@ices.astar.edu.sg Zhang_mingzi@ices.astar.edu.sg zhao_hua@ices.astar.edu.sg zhong_ziyi@ices.astar.edu.sg Jan 2015 Full list of supervisors Zhu Kewu GSK Evidence-based Formulation 1. Powder technology: powder flow, fluidization, pneumatic conveying, granulation, coating, milling, dispersion, tableting zhu_kewu@ices.astar.edu.sg 2. Drug delivery: Respiratory drug delivery – - Formulation development for metered dose inhaler - Formulation development for dry powder inhaler - Inhalation product performance characterization and evaluation - Dry powder inhaler/metered dose inhaler device development, evaluation, and optimization Zhu Yinghuai Heterogeneous Catalysis 3. Solid dosage form development - Formulation development for solid dosage forms - Process development and scale up for solid dosage forms Design and synthesis of organometallic compounds using as catalysts for olefin polymerization, asymmetric addition, and metathesis reaction, Exploration of novel agents such as smart nanomaterials for catalyst support and drug delivery, Producing chemical and material from biomass. zhu_yinghuai@ices.astar.edu.sg Jan 2015