1. Loci identified using variance components methods (LOD>2.0) in Pima Indians.
Trait Chrom.
Young-Onset T2DM
Respiratory Quotient
HDL-Cholesterol
Leptin
1
1
3
6
Young-Onset T2DM
2-Hour Insulin after OGTT
7
9
Body Mass Index 11
Parent of Origin affect on Birth Weight 11
Percent Fat
Total Cholesterol
Insulin Action
Fasting Glucose
18
19
22
22 cM
170
105
181
54
54
0
0
46
120
99
139
88
LOD Reference
2.5
2.8
2.6
2.1
2.0
2.2
3.6
3.4
2.3
3.9
2.1
2.4
1
2
3
4
2
3
5
5
1
5
1
6
2. Genes analyzed as positional candidates for linkage in Pima Indians.
Chromosome 1q21-24 (Young Onset T2DM)
Gene Reference
ENSA
IL6R
PTGS2
MGST3
PLA2G4A
CRP
PRKAB2
KCNJ9
KCNJ10
LMX1A
INSRR
LMNA
PEA15
MTG8
SLC19A2
PBX1
PKLR
RXRG
MGST3
13
14
15
16
17
18
7
8
9
10
11
12
19
20
21
22 unpublished unpublished unpublished

GRIK4
SC5DL
ZNF202
SP17
NRGN
BCSC
TBRG1
PANX3
CTH
PKNOX2
FEZ
SP10
PIG8
NEPH-2
ETS-1
FLI1
KCNJ1
KCNJ5
KIAA 0712
BARX2
NFRKB
APLP2
HNT
OPCML
B3GAT1
Chromosome 11q23-24 (Body Mass Index)
Gene
DRD2
ORP150
NCAM
PLZF
NNMT
Reference
23
24 unpublished unpublished unpublished
IGS4
ZNF259
APOA1
APOA3
APOA4
APOA5 unpublished unpublished unpublished unpublished unpublished unpublished
TAGLN
PCSK7
ARCN1
CBL2
C1Q TNF
THY1
ARHGEF12 unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished unpublished
2

Chromosome 7q (Young Onset T2DM)
Gene Reference
PPP1R3 25
Chromosome 19p (Total serum cholesterol)
Gene Reference
LDLR unpublished
Chromosome 11p (Parent of origin effect on birth weight)
Gene
INS
Reference
26
References for Online Appendix
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Norman RA, Tataranni PA, Pratley R, Thompson DB, Hanson RL, Prochazka M,
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Bennett, and Leslie J. Baier The insulin gene variable number tandem repeat class I/III polymorphism is in linkage disequilibrium with birth weight but not Type 2 diabetes in the Pima population. Diabetes. 52: 187-93, 2003.
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