BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Carol P. Moreno Quinn
POSITION TITLE
Associate Professor eRA COMMONS USER NAME (credential, e.g., Department of Physiology agency login) cpmquinn cpmquinn
(Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)
INSTITUTION AND LOCATION
Universidad de Murcia, Murcia, Spain
Universidad de Murcia, Murcia, Spain
Medical College of Wisconsin, Milwaukee, WI
Medical College of Wisconsin, Milwaukee, WI
DEGREE
(if applicable)
MD
Ph.D.
Postdoc
Postdoc.
MM/YY
1989-1995
FIELD OF STUDY
Medicine & Surgery
1995-1999 Physiology & Pharmac
2000-2002 Renal and CV Phys
2002-2004 Genomics
A. Personal Statement
B. Positions and honors
Positions
2004 – 2011 Assistant Professor , Department of Physiology Medical College of Wisconsin.
2011 – present Associate Professor , Department of Physiology Medical College of Wisconsin.
2003 – 2011 Consultant , Physiogenix, Milwaukee, Wisconsin.
2011- present Consultant , Plato Biopharma, Denver, Colorado.
2011- present Consultant , Medivation, San Francisco, California.
Other Experience and Professional Memberships
2005 Elected Fellow of the American Heart Association.
2006 Scientific and Organizing Committee for the 1st International Symposium on Hypertension, Osijek,
Croatia.
2007 Member of the Organizing Committee for the 2007 World Congress of Microcirculation
2005 – 2008 Member Faculty Development Committee, Medical College of Wisconsin.
2007 – 2008 Chair Faculty Development Committee, Medical College of Wisconsin.
2007 – present Associate Editor. Physiological Genomics.
2009- present - Member of the IACUC Committee, Medical College of Wisconsin
2009-2012 Physician Scientist Pathway Committee. Medical College of Wisconsin.
2009-2012 Member of Academic Standing Committee, Medical College of Wisconsin
2009-2011 Chief Editor, Frontiers in Genomic Physiology
2009-2014 American Society of Physiology. Physiological Genomics Group Steering Committee.
2010-2011 LCME Education Program Self-Study Subcommittee. Medical College of Wisconsin.
2011 American Society of Physiology. Water and Electrolyte Homeostasis Section Award Committee
2011-2012 Faculty Career Development Committee. Medical College of Wisconsin.
2011-2013 New Curriculum Development Committee. Medical College of Wisconsin.
2011-2014 Chair. Trainee Advisory Committee. Physiological Genomics APS Group.
2011-present American Heart Association review panel member
Honors
1996-1999 Predoctoral Fellowship, Spanish Ministry of Education.
1999 Short Visit Research Award, Spanish Ministry of Education.
1999 Short Visit Research Award, Merck-Spanish Society of Hypertension.
2001 Postdoctoral Fellowship Award, Seneca Foundation, Spain.
2001-2003 Postdoctoral Fellowship Award, Spanish Ministry of Education.
2001 Caroline Tum Suden Professional Opportunity Award, Am Phys Soc.

2002 Aventis Pharma New Investigator Travel Award, American Heart Association
2003 APS Travel Award: Understanding Renal and Cardiovascular Function through
Physiological Genomics
2006 APS Star Reviewer for Physiological Genomics.
2009 APS Water and Electrolyte New Investigator Award
2009 - NIH Travel Award. Genetics of Urologic Malformations
2011 APS Star Reviewer for Physiological Genomics.
C. Selected peer-reviewed publications (in chronological order; selected from 41 publications).
1. Moreno C , Dumas P, Kaldunski ML, Tonellato PJ, Greene AS, Roman RJ, Cheng Q, Wang Z,
Jacob HJ, Cowley AW Jr. Genomic map of cardiovascular phenotypes of hypertension in female
Dahl S rats. Physiological Genomics 15(3):243-57, 2003. PMID: 14532335
2. Moreno C , Kaldunski, ML Wang T, Roman RJ , Greene AS, Lazar J, Jacob HJ, Cowley AW Jr.
Multiple blood pressure loci on rat Chromosome 13 attenuate the development of hypertension in the Dahl S Hypertensive rat. Physiological Genomics, 31(2):228-35, 2007. PMID: 17566075
3. Moreno C , Jacob HJ, Cowley AW Jr. Attaching physiology to the genome. In: Handbook of
Hypertension. Anna Dominikzac (editor). Elsevier, 2007.
4. Moreno C , Lazar J, Jacob HJ, Kwitek AE. Comparative genomics for detecting human disease genes. Adv Genet. 60:655-97, 2008. PMID: 18358336
5. Aitman T, Critser JK, Cuppen E, Dominiczak A, Fernandez XM, Flint J, Gauguier D, Geurts AM,
Gould M, Harris PC, Holmdahl R, Hubner N, Izsvak Z, Jacob HJ, Kuramoto T, Kwitek AE, Marrone
A, Mashimo T, Moreno C , Mullins J, Mullins L, Olsson T, Riley L, Saar K, Serikawa T., Shull JD,
Szpirer C, Twigger SN, Voigt B, Worley K. Progress and prospects in rat genetics. Nature
Genetics, 40(5):516-22, 2008. PMID: 18443588
6. Lu L, Li P, Yang C, Kurth T, Misale M, Skelton MM, Moreno C , Roman RJ, Greene AS, Jacob HJ,
Lazar J, Liang M, Cowley Jr AW. Dynamic convergence and divergence of renal genomics and biological pathways in protection from Dahl salt-sensitive hypertension. Physiological Genomics.
2010 Mar 3;41(1):63-70. PMID: 20009007.
7. Adamovic T, McAllister D, Wang T, Adamovic D, Rowe JJ, Moreno C , Lazar J, Jacob HJ, Sugg SL.
Identification of Novel Carcinogen-mediated Mammary Tumor Susceptibility Loci in the Rat Using the Chromosome Substitution Technique. Genes, Chromosomes and Cancer. 2010. 2010
Nov;49(11):1035-45. PMID: 20737482
8. Durand MJ, Moreno C , Greene AS, Lombard JH. Impaired relaxation of cerebral arteries in the absence of elevated salt intake in normotensive congenic rats carrying the Dahl salt-sensitive renin gene. Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1865-74. PMCID: 20852041
9. Geurts AM, Moreno C . Zinc-finger nucleases: new strategies to target the rat genome. Clin Sci
(Lond). 2010 Jul 6;119(8):303-11. PMID: 20615201
10. O'Meara CC, Lazar J, Hoffman M, Moreno C , Jacob HJ. Refined Mapping of the Renal Failure Rf-
3 Quantitative Trait Locus. J Am Soc Nephrol. 2011. Mar;22(3):518-25. PMID: 21127141
11. Moreno C , Hoffman M, Stodola TJ, Didier DN, Lazar J, Geurts AM, North PE, Jacob HJ, Greene
AS. Creation and characterization of a renin knock out rat. Hypertension. 2011 Mar;57(3):614-9.
PMID: 21242461
12. Wang Q, Chow J, Hong J, Smith AF, Moreno C , Seaby P, Vrana P, Miri K, Tak J, Chung E,
Mastromonaco G, Cannigia I, Varmuza S. Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs. BMC Genomics. 2011 Apr 21;12(1):204.
PMCID: 21510876
13. Moreno C , Williams JM, Lu L, Liang M, Lazar J, Jacob HJ, Cowley AWJr, Roman RJ. Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS-13BN congenic strains. Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1530-5. PMID: 21257920
14. Stodola TJ, de Resende MM, Sarkis A, Didier DN, Jacob HJ, Huebner N, Hummel O, Saar K,
Moreno C , Greene AS. Characterization of the genomic structure and function of regions influencing renin and angiogenesis in the SS rat. Physiol Genomics. 2011 Jul 14;43(13):808-17.
PMID: 21521778.

15. Stekiel TA, Contney SJ, Roman RJ, Weber CA, Stadnicka A, Bosnjak ZJ, Moreno C .
Pharmacogenomic Strain Differences in Cardiovascular Sensitivity to Propofol. Anesthesiology.
2011 Dec;115(6):1192-1200. PMID: 22020141
D. Research Support
Ongoing Research Support
Faculty Development Funding 6/1/10-5/31/13
Source:Department of Physiology and Human and Molecular Genetics Center
Goal: Startup Funds for personnel support and lab supplies
2 P01 HL082798-06A1(Cowley, PI) 8/1/11-7/30/16
NIH
Title: Genetic and Physiological Basis of Salt-Induced Hypertension
Goal: To study the pathways involved in the development of hypertension and to positionally clone genes for hypertension and angiogenesis in rat chromosome 13.
Role: Genomics Core B Director
1P50 DK079306 (Avner, PI)
NIH
10/01/08-9/30/12
Title: Integrative Biology of Childhood Kidney Disease.
Goal: To find modifier genes that affect the development of renal disease in a rat model of ARPKD, that can be later translated to humans.
Role: Principal Investigator of P&F project. Co-PI for project 1 and Genomics Core.
Completed
1 P01 HL082798-01A1 (Cowley, PI) 8/1/06-7/30/11
NIH
Title: Genetic and Physiological Basis of Salt-Induced Hypertension
Goal: To study the interaction of genes on Chr. 13 in the development of hypertension and to positionally clone genes for hypertension and angiogenesis.
Role: Principal investigator Project 2. Core B Co-Director & Co-investigator project 2
Barth Syndrome Foundation (Quinn, PI)
Title: Creation of a Rat Model of Barth Syndrome
6/1/08-2/28/10
Goal: To develop a mammalian model of Barth Syndrome by reducing the expression of tafazzin through a transgenic RNAi rat.
Role: Principal Investigator
5 U01HL066579-06 (Jacob, PI)
NIH
8/1/04-7/31/09
Title: Knockout Rats for Physiological Genomics
Goal: To generate knockout mutations of 70 genes in three rat strains using ENU mutagenesis and highthroughput screening.
Role: Co-Investigator
2204027 (Jacob, PI)
Children’s Research Institute, Medical College of Wisconsin.
Title: Development of an animal model of ARPKD for therapy testing
Goal: Development of an animal model of ARPKD for therapy testing.
Role: Co-Investigator
2/1/06 - 1/31/08

1RC2 HL101681 (Jacob, PI)
NIH
9/30/09-9/29/11
Title: Mechanistic Characterization of Genes for Hypertension & Renal Disease
Goal: To use a novel technique to knockout genes in hypertensive and normotensive animal models to test the role of these genes in the vascular and renal mechanisms controlling blood pressure. This unique strategy will provide a mechanistic understanding of the pathophysiological role played by GWAS genes in hypertension and kidney disease.
Role: Co-Investigator