TRODAX®
Nitroxynil 34% w/v Injection BP (Vet.). Each ml contains 340 mg of active ingredient.
Trodax is presented as a solution containing 34% w/v nitroxynil (as eglumine salt).
Indications
Trodax 34% solution is indicated for the treatment of fascioliasis (infestations of mature and immature Fasciola
hepatica) in cattle and sheep. It is also effective, at the recommended dose rate, against adult and larval
infestations of Haemonchus contortus in cattle and sheep and Haemonchus placei, Oesophagostomum radiatum
and Bunostomum phlebotomum in cattle. However, Trodax should not be regarded or used as a broad-spectrum
anthelmintic.
Administration and dosage
By subcutaneous injection
Taking normal aseptic precautions the solution is injected subcutaneously at a convenient site. In sheep this site
should preferably be free from wool. The injection site is then massaged gently to disperse the solution. The
standard dosage is 10 mg nitroxynil per kg bodyweight. (1.5 ml of Trodax / 50 kg bodyweight).
Sheep
Administer Trodax 34% solution according to the following dose scale :
Liveweight
Dose
14 - 20 kg
0.5 ml
21 - 30 kg
0.75 ml
31 - 40 kg
1.0 ml
41 - 55 kg
1.5 ml
56 - 75 kg
2.0 ml
over 75 kg
2.5 ml
In outbreaks of fascioliasis, each sheep in the flock should be injected immediately the presence of the disease is
recognised, repeating treatment as necessary throughout the period when infestation is occurring, at intervals of
not less than one month. On farms with fluke-infested pastures, routine preventive dosing should be carried out
at intervals of not less than one month, having regard for such factors as the past disease history of the farm, the
frequency and severity of neighbouring outbreaks and regional fore-casts of incidence.
Cattle
1.5 ml of Trodax 34% solution per 50 kg liveweight. One injection is usually sufficient but when animals are
continuously exposed to re-infection they may be retreated at intervals of not less than one month. The treatment
of cattle helps to reduce contamination of pasture on farms where fascioliasis is endemic.
Contra-indications and adverse reactions
For animal treatment only. No systemic ill-effects are to be expected when animals (including pregnant cows and
ewes) are treated at normal dosage. Very infrequently, deaths have occurred in sheep treated in advanced stages
of liver fluke disease. Ewes in advanced pregnancy should be driven, handled and dosed carefully. Small
swellings are occasionally observed at the injection site in cattle. These can be avoided by injecting the dose in
two separate sites and massaging well to disperse the solution. In the event of accidental overdosage, dextrose
saline solution should be administered intravenously. Keep the patient cool – applications of cold water may also
be of value.
Precautions
Keep out of reach of children. Check expiry date on pack before use. Animals may be slaughtered for human
consumption only after 60 days from treatment. Trodax should not be administered to lactating cows whose milk
is for human consumption. Dairy cows should be treated at drying off (at least 28 days before calving). Trodax
causes yellow staining of the skin, not easily removed by washing. Wash splashes from skin and eyes
immediately. Suitable gloves should be worn to avoid staining the skin. Trodax solution stains and care should
be taken to avoid spilling it, especially on the fleece of sheep. Do not mix with any other preparation. No
incompatibility is to be expected if given concurrently with therapeutic doses of the following anthelmintics :
thiophanate, phenothiazine, levamisole, thiabendazole, naphthalophos, tetramisole, morantel/diethylcarbamazine
or with clostridial vaccine. Avoid the introduction of contamination during use. Should any apparent growth or
discoloration occur, the product should be discarded. Protect from light.
For animal use only
® Trodax is a trademark of Merial
Merial SAS
29, avenue Tony GARNIER
F-69 007 Lyon