"Heterogeneity and predictability of global epidemics" Vittoria COLIZZA Indiana University U.S.A. ABSTRACT We investigate the role of the large scale properties of the airline transportation network in determining the global diffusion pattern of emerging disease. We study a stochastic epidemic modeling framework that considers the complete International Air Transport Association 2002 database complemented with census population data. We adopt measures used in information theory to analyze quantitatively the level of heterogeneity and predictability of the epidemic pattern and its relation with the network's structure. The spatio-temporal heterogeneity of the spreading pattern is globally characterized and traced back to the network statistical complexity. Finally, we define a quantitative measure of the predictability of the epidemic pattern and discuss its relation with the outbreak starting point and the network structure. The presented results provide a general computational framework for the analysis of containment policies and epidemic risk assessment.