TAKAHIKO SHIBAHARA
Professor and Chairman
Department of Oral & Maxillo-Facial Surgery
Tokyo Dental College, Japan
1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan
Telephone: +81-43-270-3972
E-mail: sibahara@tdc.ac.jp
Date of Birth:
Place of Birth:
Nationality:
Marital Status:
November 6, 1954
Tokyo, Japan
Japanese
Married with 3 daughters
Professional Background
1979: D.D.S., Tokyo Dental College
1984: Ph.D., Tokyo Dental College
1987: Accredited Oral Surgeon, Japanese Society of Oral & Maxillofacial
Surgeons
1995: Accredited consultant oral surgeon, Japanese Society of Oral &
Maxillofacial Surgeons
Employment
April 1984 – March 1989:
April 1989 – August 2000:
June 1993 – October, 1994:
September 2000 – present:
August 2004 – present:
Instructor, Oral & Maxillo-Facial Surgery,
Tokyo Dental College
Assistant Professor, Oral & Maxillo-Facial
Surgery, Tokyo Dental College
Visiting
Assistant
Professor,
Oral
&
Maxillo-Facial Surgery, Medical University of
Hannover, Germany
Associate Professor, Oral & Maxillo-Facial
Surgery, Tokyo Dental College
Professor and Chairman, Oral & Maxillo-Facial
Surgery, Tokyo Dental College
Memberships
1962: Tokyo Dental College Society
1962: Japanese Society of Oral & Maxillo-Facial Surgery
1962: Japan Society for Head and Neck Cancer
1982: Japan Society of Oral Tumor
1990: Japanese Society for Jaw Deformities
1990: Japanese Cancer Research
1995: International Association of Oral & Maxillo-Facial Surgery
1996: Asian Association of Oral & Maxillo-Facial Surgeons
Current Situation and Future Directions for Molecular Studies on
Oral Cancer Prevention & Control
Prof. Takahiko Shibahara
Tokyo Dental College
Despite recent improvements in diagnostic and therapeutic technologies,
prognosis of oral squamous cell carcinoma (OSCC) has remained dismal, as
more than 50% of patients die within 5 years. Cervical lymph node or lung
metastasis has been reported to have a strong correlation with poor prognosis.
In this study, array-based comparative genomic hybridization (CGH) and
proteomics analysis with individual gene-level resolution has been carried out to
precisely identify biomarkers that reflect occurrence of metastasis in OSCC
patients.
Array-based CGH was carried out using primary tumor DNA of OSCC patient. By
using proteomic selection, functional verification and clinical validation, we have
identified specific down and up-regulation of protein. Real-time quantitative PCR
of selected gene loci was carried out to further investigate the rest of the
samples.
Gain at 11q13 region was the
only chromosomal abnormality that reached frequency of 30% exclusively in the
metastasis present patient group revealed by array-based CGH. Abnormality of
individual genes located in this region was further investigated using the rest
samples by real-time QPCR. Despite a rarity of sequence variation of the some
gene in both primary OSCC and OSCC-derived cells, a high prevalence of
hypermethylation in the CpG island region that strongly correlated to its
down-regulation was detected.
These results establish some gene as a novel target of early detection,
prevention and therapy for oral cancer metastasis.