Dr. Chen Yi-Jen
Contact Information
Phone +886-2-28757826 Ext:343
Email
chenyj@vghtpe.gov.tw
Educations
2010
PhD of Clinical Medicine Institute of Clinical Medicine Graduate School
National Yang-Ming University, Taipei, Taiwan.
1995
Doctor of Medicine, National Yang-Ming University, Taipei, Taiwan.
Experiences
2004 - present Attending Physician at Department of Obstetrics and Gynecology,
Taipei Veterans General Hospital,
University-affiliated tertiary referral center.
2002-2004
Clinical Gynecologic Oncology Fellow at Department of Obstetrics
and Gynecology,
Taipei Veterans General Hospital,
University-affiliated tertiary referral center.
2001-2002
Chief Resident at Department of Obstetrics and Gynecology,
Taipei Veterans General Hospital
1997-2001
Resident, Department of Obstetrics and Gynecology,
Taipei Veterans General Hospital
1995-1997
Army service, doctor for Air Force, ROC.
1994-1995
Medical Intern, Taipei Veterans General Hospital
Research Interests
1.
Single port surgery
2.
3.
4.
5.
Stem cell in endometriosis
Robotic surgery
Endometriosis and infertility
Oncology
Honors and Awards
Award in Excellent Teaching, Taipei Veterans General Hospital, 2002.
Award, sponsored by Memorial Sloan-Kettering Cancer Center
and MD Anderson Cancer Center. 4th Annual International Conference on Ovarian
Cancer. September 11-13, 2003 in New York City, USA.
Multidrug Resistance 1 (MDR1) Gene Polymorphism Is Associated with Poor
Prognosis of Paclitaxel-Based Chemotherapy in Patients with Ovarian Cancer
Travel Award, 6th International Conference of The Asian Clinical Oncology Society
(ACOS), November 16-19, 2003 in Seoul, Korea.
Increased Dihydrodiol Dehydrogenase Expression is Associated with Chemotherapy
Resistance in Ovarian Cancer Patients
Third Prize of the Jerome J. Hoffman Award, The American Association of
Gynecologic Laparoscopists (AAGL) 32nd Annual Meeting, November 19-22, 2003 in
Las Vegas, USA.
High Rate of Early Miscarriage After Laparoscopic Uterine Vessels Occlusion
Travel Award, 2nd Scientific Meeting of the Asia Pacific Menopause Federation.”
Sense and Science in Menopasue” ,March 9-12, 2004 in Pattaya, Thailand.
A Clinical Trial of Three Dosages of Transdermal 17beta-Estradiol Gel for Preventing
Postmenopausal Bone Loss.
2011 Award in Excellent Teaching, Taipei Veterans General Hospital.
2011: Third prize of Distinguished Thesis, Taipei Veterans General Hospital, Taiwan
2011: Award of Best paper, Taiwan Association of minimally invasive gynecology,
Taiwan
Selected publications
*Correspondence
1.
2.
Chen YJ, Ying-Jay Liou, Chia-Ming Chang, Hsin-Yang Li, Chih-Yao Chen,
Nae-Fang Twu, Ming-Shyen Yen, Yuh-Lih Chang, Chi-Hsien Peng, Shih-Hwa
Chiou, Chih-Ping Chen, Kuan-Chong Chao. Reprogramming human
endometrial fibroblast into Induced Pluripotent Stem Cells. Taiwanese
Journal of OBS & GYN 2011 (in press)(SCI)
Hsiao-Wen Tsai, Chen YJ, Chiu-Ming Ho , Shu-Shya Hseu, Kuan-Chong
Chao , Shen-Kou Tsai, Peng-Hui Wang. Maneuvers to decrease
laparoscopy-induced shoulder and upper abdominal pain: A randomized
controlled study. Archives of Surgery. 2011;146(12):1360-1366. (SCI:4.5
3.
ranking:5/187) (same contribution with first author)
Chen YJ, Wang PH, Ocampo EJ, Twu NF, Yen MS, Chao KC. Single-port
compared with conventional laparoscopic-assisted vaginal hysterectomy: a
randomized controlled trial. Obstet Gynecol. 2011 Apr;117(4):906-12.
(SCI:4.392 ranking:2/75)
4.
Tsai HW, Twu NF, Ko CC, Yen MS, Yang MJ, Chao KC, Wen L, Chen CY,
Chou YH, Chen YJ*. Compliance with screening mammography and breast
sonography of young Asian women. Eur J Obstet Gynecol Reprod Biol. 2011 Mar
23. ;157(1):89-93. (SCI:1.764, ranking: 35/75)
5.
Lau HY, Twu NF, Chen YJ, Horng HC, Juang CM, Chao KC.Comparing
effectiveness of combined transobturator tension-free vaginal mesh (Perigee) and
transobturator tension-free vaginal tape (TVT-O) versus anterior colporrhaphy and
TVT-O for associated cystocele and urodynamic stress incontinence. Eur J Obstet
Gynecol Reprod Biol. 2011 Apr 19 Jun;156(2):228-32. (SCI:1.764, ranking:
6.
7.
8.
35/75)
Chen YJ, Li HY, Huang CH, Twu NF, Yen MS, Wang PH, Chou TY, Liu YN,
Chao KC,Yang MH. Oestrogen-induced epithelial-mesenchymal transition of
endometrial epithelial cells contributes to the development of adenomyosis. J
Pathol. 2010 Nov;222(3):261-70. ( SCI=7.274, ranking: 3/76)
Chen YJ, Li HY , Chang YH, Yuan CC, Lu KH, Tai LK, Chang CM, Chiou SH
Suppression of Migratory/invasive Ability and Induction of Apoptosis in
Adenomyosis-derived Mesenchymal Stem Cells by Cyclooxygenase-2 Inhibitors.
Fertil Steril. 2010 Nov;94(6):1972-1979.e4 (SCI:3.92, ranking: 4/75)
Li HY ,Chen YJ , Chen SJ, Kao CL, Tseng LM, Lo WL, Chang CM, Yang DM,
Ku HH, Twu NF, Liao CY, Chiou SH, Chang YL .Induction of Insulin-Producing
Cells Derived from Endometrial Mesenchymal Stem-like Cells. J Pharmacol Exp
Ther. 2010 Dec;335(3):817-29. (same contribution with first author)
(SCI:4.014, ranking:40/249)
9.
Wen KC, Chen YJ, Sung PL, Wang PH. Comparing uterine fibroids treated by
myomectomy through traditional laparotomy and 2 modified approaches:
ultraminilaparotomy and laparoscopically assisted ultraminilaparotomy. Am J
Obstet Gynecol. 2010 Feb;202(2):144.e1-8. (same contribution with first
author) (SCI:3.313, ranking: 8/75)
10.
Sun HD, Chao KC, Shen SH, Lai CR, Twu NF, Yuan CC, Yen MS, Wu HH, Chen
YJ*. Brain metastasis of ovarian epithelial carcinoma. Taiwan J Obstet Gynecol.
2010. Mar;49(1):101-4.
11.
Chen YJ, Chen CM, Twu NF, Yen MS, Lai CR, Wu HH, Wang PH, Yuan CC.
Overexpression of Aurora B is associated with poor prognosis in epithelial ovarian
cancer patients. Virchows Arch. 2009; 455:431-440. (SCI:2.336, ranking: 27/76)
12.
Twu NF, Yuan CC, Yen MS, Lai CR, Chao KC, Wang PH, Wu HH, Chen YJ*.
Expression of Aurora kinase A and B in normal and malignant cervical tissue:
High Aurora A kinase expression in squamous cervical cancer. Eur J Obstet
Gynecol Reprod Biol. 2009 Jan;142(1):57-63. (SCI:1.764, ranking: 35/75)
13.
Sung PL, Chao KC, Twu NF, Wang PH, Yu BK, Yen MS, Yuan CC, Chen YJ*.
Taiwan J Obstet Gynecol. 2007 Mar;46(1):71-2. Postconization cervical
perforation during laparoscopic surgery. (SCI)
14.
Tsai HW, Huang WJ, Chen CY, Chiang MM, Chao KC, Shen SH, Hung JH, Chen
YJ.*Two and Three-dimensional Trans-vaginal Doppler Ultrasound Analysis of
Urethral Clear Cell Carcinoma. Letter to the Editor. Ultrasound Obstet Gynecol.
2007 Jun;29(6):713-6. (SCI=3.163, ranking: 9/75)
15.
Twu NF, Chen YJ, Wang PH, Yu BK, Lai CR, Chao KC, Yuan CC, Yen MS.
Improved Conventional Cervical Cancer Screening (Pap Smear Screening ) in
Premenopausal Women by Combination of Pap Smear and Speculoscopy
(PapSure Examination) Eur J Obstet Gynecol Reprod Biol, 2007 (133) 114-8.
(same contribution with first author) (SCI:1.764, ranking: 35/75)
16.
Chen YJ, Yuan CC, Chow KC, Wang PH, Lai CR, Yen MS, Wang LS.
Overexpression of dihydrodiol dehydrogenase is associated with cisplatin-based
chemotherapy resistance in ovarian cancer patients.
17.
18.
Gynecologic Oncology. 2005 Apr;97(1):110-7. ( SCI: 3.760, ranking: 4/75)
Chen YJ, Peng-Hui Wang,, Chiou-Chung Yuan, Yuan-Kuei Yen, Ming-Jie Yang,
Heung-Tat Ng, Sheng-Ping Chang, Wei-Min Liu. (2003) Capsule Summaries
from the literature ø“regnancy Following Treatment of Symptomatic Myomas
with Laparoscopic Bipolar Coagulation of Uterine Vessels. Hum Repro.
18(5):1077-81”
J Am Assoc Gynecol Laparosc. 2003;10(4):576. (SCI: 1.920,
ranking: 27/70)
Chen YJ, Peng-Hui Wang,, Chiou-Chung Yuan, Yuan-Kuei Yen, Ming-Jie Yang,
Heung-Tat Ng, Sheng-Ping Chang, Wei-Min Liu. (2003) Pregnancy Following
Treatment of Symptomatic Myomas with Laparoscopic Bipolar Coagulation of
19.
20.
Uterine Vessels. Hum Repro. 18(5):1077-81. (SCI: 3.859, ranking: 3/70)
Chen YJ, Tzay-Shing Yang, Huai-Ling Wang , Sheng-Ping Chang, Chiou- Chung
Yuan. (2003) The effects of sequentially combined hormone replacement therapy
on climacteric symptoms and lipid profiles. Taiwanese J Obstet Gynecol.
42(4):239-46.
Chen YJ, Chang SP, Yuan CC, Chuang TY, Yu KJ, Wang PH. (2003) Acute
Urinary Retention After Assisted Reproductive Technology. J Repord
Med.48:560-2. (SCI: 0.696, ranking: 58/70)
21.
Chen YJ, Wang LS, Wang PH, Lai CR, Yen MS, Ng HT, Yuan CC. High
cyclooxygenase-2 expression in Cervical adenocarcinomas. Gynecol Oncol. 2003
22.
88(3): 379-385. ( SCI: 3.733, ranking: 5/70)
Chen YJ, Wang PH, Yuan CC, Wu YC, Liu WM. Early pregnancy uninterrupted
by laparoscopic bipolar coagulation of uterine vessels. J Am Assoc Gynecol
23.
Laparosc. 2002 Feb 9(1):79-83. (SCI: 1.920, ranking: 27/70)
Chen YJ, Wang PH, Yuan CC, Yang MJ, Yen YK, Liu WM. Successful pregnancy
in a woman with symptomatic fibroids who underwent laparoscopic bipolar
coagulation of uterine vessels. Fertil Steril. 2002 Apr 77(4):838-40. (SCI: 3.970,
24.
ranking: 3/70)
Chen YJ, Wang PH, Yuan CC. (2000 Dec,) Successful treatment of pelvic
recurrent vulvar melanoma. Int J Gynaecol Obstet. 71(3):275-6. (SCI: 1.408,
ranking: 41/70)
Chen YJ, Wang PH, Liu WM, Lai CR, Shu LP, Hung JH. (2002 Jun) Placenta
accreta diagnosed at 9 weeks' gestation. Ultrasound Obstet Gynecol. 19(6):620-2.
(SCI=3.154, ranking: 8/70) (NSC90-381)
*Non first author
1.
2.
3.
Chang YL, Chen SJ, Kao CL, Hung SC, Ding DC, Yu CC, Chen YJ, Ku HH, Lin
CP, Lee KH, Chen YC, Wang JJ, Hsu CC, Chen LK, Li HY, Chiou SH.
Docosahexaenoic Acid Promotes Dopaminergic Differentiation in Induced
Pluripotent Stem Cells and Inhibits Teratoma Formation in Rats with
Parkinson-like Pathology. Cell Transplant. 2011 Jun 7. [Epub ahead of print]
(SCI:6.204, ranking: 1/25, 4%).
Li HY, Liao CY, Lee KH, Chang HC, Chen YJ, Chao KC, Chang SP, Cheng HY,
Chang CM, Chang YL, Hung SC, Sung YJ, Chiou SH. Collagen IV significantly
enhances migration and transplantation of embryonic stem cells: involvement of
α2β1 integrin-mediated actin remodeling. Cell Transplant. 2011;20(6):893-907.
(SCI:6.204, ranking: 1/25, 4%).
Li HY, Chien Y, Chen YJ, Chen SF, Chang YL, Chiang CH, Jeng SY, Chang CM,
Wang ML, Chen LK, Hung SI, Huo TI, Lee SD, Chiou SH.
Reprogramming
induced pluripotent stem cells in the absence of c-Myc for differentiation into
hepatocyte-like cells. Biomaterials. 2011 Sep;32(26):5994-6005. (SCI: 7.883,
4.
ranking: 2/70, 2.85%).
Twu NF, Yen MS, Lau HY, Chen YJ, Yu BK, Lin CY. Type-specific human
papillomavirus DNA testing with the genotyping array: a comparison of cervical
and vaginal sampling. Eur J Obstet Gynecol Reprod Biol. 2011 Jan 31.
(SCI:1.764, ranking: 35/75)
5.
Unilateral salpingo-oophorectomy as fertility-sparing surgery for borderline ovarian
tumors. Tsai HW, Ko CC, Yeh CC, Chen YJ, Twu NF, Chao KC, Yen MS. J Chin
Med Assoc. 2011 Jun;74(6):250-4. Epub 2011 May 12.
6.
Chiou SH, Chen SJ, Chang YL, Chen YC, Li HY, Chen DT, Wang HH, Chang CM,
Chen YJ, Ku HH. MafA promotes the reprogramming of placenta-derived
multipotent stem cells into pancreatic islets-like and insulin-positive cells. J Cell Mol
7.
Med. 2011 Mar;15(3):612-24. (SCI:4.61, ranking: 18/106, 16.98%).
Kao CL, Tai LK, Chiou SH, Chen YJ, Lee KH, Chou SJ, Chang YL, Chang CM,
Chen SJ, Ku HH, Li HY. Resveratrol promotes osteogenic differentiation and
protects against dexamethasone damage in murine induced pluripotent stem cells..
Stem Cells Dev. 2010 Feb;19(2):247-58. (same contribution with 2nd author)
8.
9.
(SCI:4.146, ranking: 18/93).
Li HY, Liao CY, Lee KH, Chang HC, Chen YJ, et al. Collagen IV Significantly
Enhances Migration and Transplantation of Embryonic Stem Cells: Involvement
of α2β1 Integrin-mediated Actin Remodeling. Cell Transplant. 2010 Dec 22.
[Epub ahead of print] (SCI:6.204, ranking: 1/25).
Higuchi A, Ling-Yi H, Huang LY, Chen H, Chen YJ, Ling QD. Measurements of
movement and diffusion coefficients of single cells on polymeric surface from
image analysis. J Biomater Sci Polym Ed. 2010;21(12):1545-58. Epub 2010 Jun 9.
10.
Wang PH, Chen YJ, Horng HC. Is it possible to use a single ancillary trocar to
finish laparoscopic cystectomy? Taiwan J Obstet Gynecol. 2009 Dec;48(4):333-4.
11.
Aggressive characteristics of cervical cancer in young women in Taiwan. Lau HY,
Juang CM, Chen YJ, Twu NF, Yen MS, Chao KC. Int J Gynaecol Obstet. 2009
Dec;107(3):220-3. Epub 2009 Aug 27.
12.
Sung PL,Chen YJ , Liu RS, Shieh HJ, Wang PH, Yen MS, Wen KC, Shen SH,
Lai CR, Yuan CC. Whole-body positron emission tomography with
18F-fluorodeoxyglucose is an effective method to detect extra-pelvic recurrence in
uterine sarcomas. Eur J Gynaecol Oncol. 2008;29(3):246-51. (SCI=0.314,
13.
14.
ranking: 60/70).
Tsai HW, Chen YJ, Twu NF, Lai CR, Shen SH, Yen MS, Chao KC. Primary
appendiceal malignancy mimicking advanced stage ovarian cancer. Taiwan J
Obstet Gynecol. 2007 Sep;46(3):304-7
Wang PH, Horng HC, Chen YJ, Hsieh SL, Chao HT, Yuan CC.Effect of a
selective nonsteroidal anti-inflammatory drug, celecoxib, on the reproductive
function of female mice. J Chin Med Assoc. 2007 Jun;70(6):245-8. ( SCI: 1.5)
15.
16.
17.
Tzay-Shing Yang, Yi-Jen Chen, Wei-Hsing Liang, Cheng-Yen Chang,
Ling-Chen Tai, Sheng-Pin Chang, and Heung-Tat Ng.A Clinical Trial of Three
Doses of Transdermal 17 β-estradiol for Preventing Postmenopausal Bone Loss: A
Preliminary Study. J Chin Med Assoc. 2007 May;70(5):200-6. ( SCI: 1.5)
Sung PL, Chao KC, Twu NF, Wang PH, Yu BK, Yen MS, Yuan CC, Chen YJ.
Alpha 2,6-sialyltransferase I expression in the placenta of patients with
preeclampsia. J Chin Med Assoc. 2007 Apr;70(4):152-8. ( SCI: 1.5)
Chou YC, Chen YJ, Lai CR, Wang PH, Chan H, Yuan CC. Cyclooxygenase-2
expression is higher in ovarian cancer tissue adjacent to endometriosis than in
ovarian cancer without comorbid endometriosis.(2006) Eur J Obstet Gynecol
Reprod Biol.
124(1):101-5. (SCI:1.582, ranking: 39/70)
Lab Members
Research assistants: Pei-Yin Su; Shr-Yun Chiou
Lab Photos