1 CURRICULUM VITAE SAMUELE CORTESE, M.D. Personal data Name: Samuele Cortese Sex: Male Birthdate: April 23, 1974 Birthplace: Verona (Italy) Professional address: Service de Psychopathologie de l’Enfant et de l’Adolescent, Hôpital Robert Debré, 48 Bd Sérurier, 75019, Paris, France E-mail: samuele.cortese@gmail.com; neurosamu@tin.it; samuele.cortese@rdb.aphp.fr Citizenship: Italian Languages: Italian, English, French Academic Training 1999: M.D. summa cum laude (110/110 cum laude), Verona University, Verona, Italy 2004: Specialty in Child Neuropsychiatry, summa cum laude (50/50 cum laude), Verona University, Verona, Italy 2006-present: Ph.D. candidate, Verona University, Verona, Italy (in partnership with Paris VII University, Paris, France). Traineeship 1996-1999: Medical Internship, Verona University, Verona, Italy 2000-2003: Child Neuropsychiatry Residency, Child Neuropsychiatry Unit, G.B. Rossi Hospital, Verona University, Verona, Italy January-February 2004: Child Psychopathology Residency, Child and Adolescent Psychopathology Unit, Robert Debré Hospital, Paris VII University, Paris, France March-July 2004: Child Psychopathology Residency, Child Psychiatry Unit, Necker-Enfants Malades Hospital, Paris V University, Paris, France 2006-present: Chief Resident-Assistant, Child and Adolescent Psychopathology Unit, Robert Debré Hospital, Paris VII University, Paris, France 2 September 2007-present: visiting fellow at the « Neuroimaging & Psychiatry » U797 Unit, Hospital Department Frédéric Joliot, Orsay, France Professional Organizations and Societies: Italian Society of Child and Adolescent Neuropsychiatry (psychiatry and neuropsychology section) Research experience: January 2005-May 2006: Clinical research fellow, Child and Adolescent Psychopathology Unit, Robert Debré Hospital, Paris VII University, Paris, France Areas of research: ADHD (iron metabolism in ADHD; sleep disorders associated with ADHD; relationship between Restless Legs Syndrome and ADHD; eating disorders associated with ADHD; relationship between ADHD and obesity; molecular genetics of ADHD) Honors: Award for the best oral communication at the XXII Congress of the Italian Society of Child and Adolescent Neuropsychiatry-Naples (Italy)-December 2005 Teaching Experience and Responsibilities : Courses and Lectures: Verona University Medical Students, Child Psychiatry Seminars: 4 per year (2001-2003) Paris VII University Medical Students, Child Psychiatry Seminars: 2 per year (2006-present) Child and Adolescent Psychopathology Unit, Robert Debré Hospital, Paris VII University, Residents, Seminars: 4 per year: (2006-present) Supervision of Students in Clinical Services: Verona University Medical Students: 2000-2003 Paris VII University Medical Students: 2005-present Child and Adolescent Psychopathology Unit, Robert Debré Hospital, Paris VII University, Residents: 2006-present Thesis Advisor to Medical Students: Marco Angriman, Verona University School of Medicine Thesis, Verona, Italy, 2002 Brenda Vincenzi, Verona University School of Medicine Thesis, Verona, Italy, 2003 Monica Coghi, Verona University School of Medicine Thesis, Verona, Italy, 2004 Erica Comencini, Verona University School of Medicine Thesis, Verona, Italy, 2007 3 Bibliography: Reviews and meta-analyses (Peer Reviewed and/or with impact factor): 1. Cortese S, Konofal E, Lecendreux M, Arnulf I, Mouren MC, Darra F, Dalla Bernardina B, Mouren MC. Restless legs syndrome and attention-deficit/hyperactivity disorder: a review of the literature. Sleep 2005, 28 (8): 1007-1013 IF : 5.12 2. Cortese S, Konofal E, Yateman N, Mouren MC, Lecendreux M. Sleep and alertness in children with attention-deficit/hyperactivity disorder: a systematic review of the literature. Sleep 2006, 29(4): 504-11 IF : 5.12 3. Cortese S, Dalla Bernardina B, Mouren MC. Attention-Deficit/Hyperactivity Disorder (ADHD) and binge eating. Nutrition Reviews 2007, 65(9):404-11. IF: 2.93 4. Cortese S, Konofal E, Mouren MC, Dalla Bernardina B, Lecendreux M. Does excessive daytime sleepiness contribute to explaining the association between obesity and symptoms of Attention-Deficit/Hyperactivity Disorder? Medical Hypotheses 2008, 70: 12-16. IF: 1.29 5. Cortese S, Angriman A, Maffeis C, Isnard P, Konofal E, Lecendreux M, Purper-Ouakil D, Vincenzi B, Dalla Bernardina B, Mouren MC. Attention-deficit/hyperactivity disorder (ADHD) and obesity: a systematic review of the literature. Critical Reviews in Food Science and Nutrition, sous presse IF: 3.80 6. Cortese S, Lecendreux M, Dalla Bernardina B, Mouren MC, Sbarbati A, Konofal E. Attention-Deficit/Hyperactivity Disorder, Tourette’s syndrome, and Restless Legs Syndrome: the iron hypothesis, Medical Hypotheses, sous presse IF: 1.29 7. Lecendreux M, Cortese S. Treatment of sleep problems associated with AttentionDeficit/Hyperactivity Disorder. Expert Review of Neurotherapeutics, in press 8. Cortese S, Mouren MC. Traitements médicamenteux du trouble déficit l’attention/hyperactivité chez l’enfant et l’adolescent. Médecine et Science, in press de Original Articles (Peer-Reviewed and/or with impact factor): 1. Darra F, Fiorini E, Zoccante L, Torniero C, Cortese S, Meneghello L, Fontana E, Dalla Bernardina B. Benign myoclonic epilepsy in infancy (BMEI): a longitudinal electroclinical study of 22 cases. Epilepsia. 2006;47 Suppl 5:31-5. IF: 3.52 2. Cortese S, Isnard P, Frelut MLG, Michel G, Guedeney A, Falissard B, Acquaviva E, Dalla Bernardina B, Mouren MC. Association between symptoms of Attention-Deficit/Hyperactivity Disorder and bulimic behaviors in a clinical sample of severely obese adolescents, International Journal of Obesity 2007, 31(2):340-6. IF: 4.04 3. Konofal E, Cortese S, Marchand M, Mouren MC, Arnulf I, Lecendreux M. Impact of Restless Legs Syndrome and iron deficiency on Attention-Deficit/Hyperactivity Disorder in children. 4 Sleep Med 2007, 8(7-8):711-715. IF: 2.97 4. Cortese S, Maffeis C, Konofal E, Lecendreux M, Comencini E, Angriman M, Vincenzi B, Pajno Ferrara F, Mouren MC, Dalla Bernardina B. Parent reports of sleep/alertness problems and ADHD symptoms in a sample of obese children and adolescents. Journal of Psychosomatic Research, 2007, 63: 587-590. IF: 2.33 5. Purper-Ouakil D, Cortese S, Wohl M, Asch M, Acquaviva E, Michel G, Gorwood P, Mouren MC. Predictors of diagnostic delay in a clinical sample of French children with AttentionDeficit/Hyperactivity Disorder. European Child and Adolescent Psychiatry, 2007, 16: 505-9. IF: 1.82 6. Konofal E, Lecendreux M, Deron J, Marchand M, Cortese S, Zaïm M, Mouren MC, Arnulf I. Effects of Iron Supplementation on Attention Deficit Hyperactivity Disorder in Children. Ped Neurol, 2008, 38: 20-6. IF : 1.54 7. Wohl M, Boni C, Asch M, Cortese S, Orejana S, Mouren MC, Gorwood P, Purper-Ouakil D. Lack of association of the dopamine transporter gene in a French ADHD sample. Am J Genet B Neuropsychiatr Genet, 2008, sous presse. IF: 4.46 Case reports (Peer-Reviewed, with impact factor): 1. Konofal E, Cortese S, Lecendreux Michel, Arnulf I, Mouren MC. Effectiveness of iron supplementation in a young child with ADHD. Pediatrics 2005; 116(5):e732-4 FI : 5.02 2. Cortese S, Konofal E, Lecendreux M, Mouren MC, Dalla Bernardina B. Restless Legs Syndrome triggered by heart surgery in a 9-year-old child. Pediatric Neurology 2006, 35(3):223-6 FI : 1.52 3. Cortese S, Konofal E, Lecendreux M. Effectiveness of ropinirole for RLS and depressive symptoms in an 11-year-old girl. Sleep Med, sous presse FI: 2.97 Letters to the Editor (Peer-Reviewed, with impact factor): 1. Konofal E, Cortese S. Restless legs syndrome and attention-deficit/hyperactivity disorder. Annals of Neurology 2005: 58 (2): 340-1 FI: 8.01 2. Cortese S, Lecendreux M, Mouren MC, Konofal E. ADHD and Insomnia. Journal of the American Academy of Child and Adolescent Psychiatry 2006, 45(4):384-5 FI: 4.76 3. Cortese S, Isnard P, Dalla Bernardina B, Mouren MC Attention-Deficit Hyperactivity Disorder, obesity and binge eating. Journal of Clinical Psychiatry 2007, 68(6): 976 FI: 5.53 3. Konofal E, Cortese S. Lead and iron neuroprotection in attention-deficit hyperactivity disorder. Environmental Health Perspectives, 2007, 115(8):A398-9. FI: 5.81 4. Konofal, E, Cortese S, Lecendreux M. Iron deficiency and periodic leg movement disorder of sleep. Sleep Med, sous presse FI: 2.9 5 Other publications (Non-Peer-Reviewed, without impact factor): 1. Zoccante L, Cortese S, Torniero C. Aspetti clinici della memoria. Ricerche e Studi in Psicologia del Corpo e in Psicomotricità 2003, 11 (1): 67-73 (Italian) 2. Cortese S, Cuzzolaro M, Maffeis C, Pajno F, Dalla Bernardina B. BIA-P (Body image assessment for preadolescents): norme italiane. Psichiatria dell’Infanzia e dell’ Adolescenza 2004, 71: 665-6. (Italian) 3. Cortese S, Cuzzolaro M, Maffeis C, Pajno F, Dalla Bernardina B. Sintomi depressivi e bassa autostima in bambini e adolescenti obesi. Minerva Pediatrica 2005, 57(2): 65-71. (Italian) 4. Cortese S, Maffeis C, Pajno Ferrara F, Dalla Bernardina B. Aspetti psicopatologici associati all’obesità in età evolutiva. Giornale di Neuropsichiatria Infantile 2005; 25: 126-136 (Italian) 5. Cortese S, Purper-Ouakil D, Michel G, Mouren MC. Les troubles de la communication chez l’enfant. La Revue du Praticien-Médecin Générale. 2006, 20 :155-159 (French) 6. Purper-Ouakil D, Wohl M, Cortese S, Michel G, Mouren MC. Le trouble déficitaire de l’attention-hyperactivité (TDA/H) de l’enfant et de l’adolescent. Annales Médico Psychologiques. 2006; 164: 63-72 (French) 7. Cortese S, Konofal E, Yateman N, Mouren MC, Lecendreux M. Sleep disturbances in children with ADHD. The ADHD Report 2006, 14 (3): 6-11 8. Cortese S, Lecendreux M, Konofal E, Pajno Ferrara F, Dalla Bernardina B. Alterazioni del sonno e della vigilanza nei bambini con ADHD. Giornale Italiano di Neuropsichiatria infantile, 2006, 4: 15-22. Chapters : 1. Cortese S. Fer et TDAH, In : Bouvard (Ed). L’hyperactivité de l’enfance à l’âge adulte. Doin ed. (2e édition) Paris, 2006 (French) 2. Mouren MC, Cortese S. Les troubles du sommeil. In: Bailly D, Mouren MC (Eds). Les prescriptions médicamenteuses en psychiatrie de l’enfant et de l’adolescent. Masson, Paris, 2007 (French) 3. Cortese S, Lecendreux M. Sleep Problems in Children with ADHD: Impact of Treatment and Co-Morbidities. In: A. Ivanenko Ed: Sleep and Psychiatric Disorders in Children and Adolescents. Informa Healthcare, NY, in press Abstracts: 1. Rigobello F, Pajno-Ferrara F, Padovani EM, Cortese S, Zardini E: “Presa in carico psicologica delle mamme con gravidanza a rischio. Risultati preliminari”. IX meeting of the Italian Society of Neonatology, 21-22 May 2003, Naples, Italy. La Pediatria Medica e Chirurgica, abstract supplement 2003, page 106 (Italian). 6 2. Zoccante L, Cortese S, Bertazzoni E, Benini A, Dalla Bernardina B. Analysis of intestinal microflora of autistic children before and after probiotic treatment. Proceedings of the II European meeting on Autism, November 14-17, 2003, Lisbon, Portugal, page 86. 3. Cortese S, Cuzzolaro M, Maffeis C, Piccolo F, Ferrucci G, Tato’ L, Pajno-Ferrara F, Dalla Bernardina B: “ Depressione, autostima e obesità in bambini e adolescenti”. Proceedings of the IX meeting of the Italian Society of Nutrition “Obesità, Sovrappeso, Magrezza”, December 2-3, 2003, Siene, Italy (Italian). 4. Cortese S, Pigaiani Y, Maffeis C, Pajno Ferrara F, Dalla Bernardina B. Immagine corporea, autostima e depressione in un campione di preadolescenti. Proceedings of the II meeting of the “Società Internazionale di Psicomotricità”, October 28-30, 2004, Verona, Italy (Italian). 5. Cortese S, Maffeis C, Pajno Ferrara F, Dalla Bernardina B. Importanza della valutazione dell‘ immagine corporea nella presa in carico psicologica dei soggetti obesi. Proceedings of the II meeting of the “Società Internazionale di Psicomotricità”, October 28-30, 2004, Verona, Italy (Italian). 6. Cortese S, Pigaiani Y, Maffeis C, Pajno Ferrara F, Dalla Bernardina B. Relazione fra peso corporeo e depressione: studio cross-sectional in un campione non clinico di 692 preadolescenti. Proceedings of the XXIV meeting of the Italian Society of Child Neuropsychiatry, November 711, 2004, Modena, Italy (Italian). 7. Cortese S, Cuzzolaro M, Maffeis C, Piccolo F, Ferrucci G, Pajno Ferrara F, Levi G, Dalla Bernardina B. Aspetti psicopatologici associati all’obesità in età evolutiva: studio crosssectional in un campione clinico di 72 bambini e preadolescenti obesi. Proceedings of the XXIV meeting of the Italian Society of Child Neuropsychiatry, November 7-11, 2004, Modena, Italy (Italian). 8. Cortese S, Maffeis C, Bogoni G, Consolaro A, Pellegrino M, Silvagni D, Viviani E, Tatò L, Dalla Bernardina B. L’eccesso ponderale può essere considerato un fattore di rischio di depressione nell’adolescente? Proceedings of the VI meeting of the Italian Society of Pediatric Nutrition, December 10-12, 2004, Milan, Italy (Italian). 9. Cortese S, Maffeis C, Bogoni G, Consolaro A, Pellegrino M, Silvagni D, Viviani E, Tatò L, Dalla Bernardina B. Obesità e psicopatologia in età evolutiva: studio psicometrico. Proceedings of the VI meeting of the Italian Society of Pediatric Nutrition, December 10-12, 2004, Milan, Italy (Italian). 10. Konofal E, Arnulf I, Cortese S, Lecendreux M, Mouren M. Ropinirole in a child with AttentionDeficit/Hyperactivity Disorder and Restless Legs Syndrome. Sleep, 28, abstract supplement 2005, page 123. 11. Cortese S, Konofal E, Lecendreux M, Mouren MC, Dalla Bernardina B. Restless legs syndrome and ADHD. The World Journal of Biological Psychiatry, abstract supplement 2005, page 245. 12 Konofal E, Cortese S, Lecendreux M, Dalla Bernardina B, Mouren MC. Iron supplementation in a young child with ADHD. The World Journal of Biological Psychiatry, abstract supplement 2005, page 267. 7 13. Cortese S, Konofal E, Arnulf I, Lecendreux M. Syndrome des jambes sans repos après intervention chirurgicale chez une fille des 9 ans. Proceedings of the Meeting of the French Society of Sleep Research, November 13, 2005, Lyon, France, page 200 (French) 14. Lecendreux M, Cortese S, Konofal E, Arnulf I, Mouren MC. Hypocretin-1 levels in a 18-yearold boy with Kleine-Levin Syndrome. Sleep Med, abstract supplement 2005, page 123. 15. Cortese S, Lecendreux M, Konofal E, Pajno-Ferrara F, Dalla Bernardina B. Le alterazioni del sonno e della vigilanza associate all’ADHD: meta-analisi. Proceedings of the XXV meeting of the Italian Society of Child Neuropsychiatry, December 7-10, 2005, Naples, Italy, (Italian). 16. Wohl M, Purper-Ouakil D, Cortese S, Hamon M, Boni C, Gorwood P. Genetical heterogeneity of ADHD: pre-results of a family based association study with DAT & 5HTT genes. Proceedings of the 6th ADHD Molecular Genetics Network. 18-19 November, 2005. Miami, Florida (USA) 17. Purper-Ouakil D, Cortese S, Wohl M, Acquaviva E. Comorbidity and diagnostic delay in attention-deficit/hyperactivity disorder. European Psychiatry 21 (suppl 1) 2006; S20. 18. Purper Ouakil D, Wohl M, Cortese S, Orejarena S, Boni C, Gorwood P. DAT 1 and treatment response in ADHD. Proceedings of the 7th ADHD Molecular Genetics Network. Bruxelles, Belgium 18-19/10/2006. 19. Konofal E, Cortese S, Lecendreux M. Effectiveness of iron supplementation in children with ADHD. Proceedings of the 53rd meeting of the American Academy of Child and Adolescent Psychiatry, San Diego, 24-29 Oct 2006 20. Cortese S, Konofal E, Lecendreux M. Sleep disturbances in children with ADHD. Proceedings of the 53rd meeting of the American Academy of Child and Adolescent Psychiatry, San Diego, 24-29 Oct 2006 21. Lecendreux M, Konofal E, Cortese S. Excessive daytime sleepiness in children and adolescents. Proceedings of the 53rd meeting of the American Academy of Child and Adolescent Psychiatry, San Diego, 24-29 Oct 2006 22. Cortese S, Angriman M, Comencini E, Maffeis C, Vincenzi B, Coghi M, Pajno Ferrara F, Dalla Bernardina B. Disturbi respiratori del sonno e sintomi di ADHD in bambini ed adolescenti sovrappeso. Proceedings of the XXV meeting of the Italian Society of Child Neuropsychiatry, Abano Terme (Padova, Italy) October 25-29, 2006, Italy (Italian) 23. Cortese S. Clinical management of sleep disturbances in ADHD. In: “Interactions between learning disorders, mild retardation and sleep disturbances in children”. Sleep Medicine 2007, 8 (Suppl 1), S37. 24. Cortese S, Konofal E, Mouren M, Dalla Bernardina B, Lecendreux M. Excessive daytime sleepiness, sleep-disordered breathing and ADHD symptoms in obese children. Sleep, 2007, Abstract book, P0209, A73. 25. Cortese S. Sleep Disordered Breathing, Excessive sleepiness, and Attention Deficit/Hyperactivity Disorder (ADHD) traits in obese children. Proceedings of the 54th meeting of the American academy of Child and Adolescent Psychiatry, Boston, 23-28 Oct 2007 8 Selected presentations: 1. Restless legs syndrome and ADHD. 8th World Congress of Biological Psychiatry, Vienna, June 28-July 3 , 2005 2. Management of RLS in patients with ADHD. 20th annual meeting of the Associated Professional Sleep Societies, Salt Lake City (UT) June 17-22, 2006 3. Sleep disturbances in children with ADHD. (In: Clinical perspectives: “Pediatric sleep Medicine Advanced Review). 53rd meeting of the American academy of Child and Adolescent Psychiatry, San Diego (CA), October 24-29, 2006 4. Management of sleep disturbances in ADHD. 2nd World Congress of Sleep Medicine, Bangkok (Thailand), February 4-8, 2007 5. Sleep disturbances associated with ADHD. (In: “Sleep Disorders in childhood psychopathology”, Co-Chair). 13th International Congress of the European Society for Child and Adolescent Psychiatry, Florence (Italy), August 25-29, 2007 6. Management of RLS in children. (In: Clinical perspectives: Behavioral and Pharmacological Management of Pediatric Sleep Disorders). 54th meeting of the American Academy of Child and Adolescent Psychiatry, Boston (MA), October 22-28, 2007 Occasional Reviewer for: Pediatrics, European Child and Adolescent Psychiatry, Sleep Medicine Tohoku Journal of Experimental Medicine, Behavioral Sleep Medicine