Contact Lens Spectrum February 2001 Document #68 References (p. 21) Potential Treatments for Dry Eye, Part I by Donald L. MacKeen, MS, PhD 1. Adler CA, Maurice DM, Paterson ME, The effect of viscosity of the vehicle on the penetration of fluorescein into the human eye, Exp Eye Res (1971) 11(1):34-42 2. Akramanian J Wedrid A Nepp J amd Salor M " Estrogen therapy in keratoconjunctivitis sicca Advan Exp Med Biol 438:1005-1009 (1998) 3. Avisar R Creter D, Levinsky, H Savir H " Comparative study o;f tear substitutes and their immediate effect on the precorneal tear film" Isr J Med Sci 1997 33(3):1947-7 4. Basilice; Vincent P. Dispensing eye drops United States Patent 5,848,999 December 15, 1998 5. Beck RE , Bhagat HG, Gessel PD, Killinger FN Physiological tear compositions and method for their preparation US Patent 5,403,598 April 4 1995 6. Bertera JH Stimulaton of lacrimal gland output : a tear jet for replacing eye moisture in Sjogren's syndrome Adv, Med Biol 350:577-582 (1994 7. Bertera JH U S Patent 5,368,582 November 29, 1994 Method and apparatus for introducing fluid material into an eye 8. Berry M. Pastis WK, Ellington RB, Frosts L Corfield AP and Easty DL "Hyaluronan in dry eye and contact lens wearers" Adv Exp Med Biol 785-90 (1998) 9. Bodor NS Androstene derivatives US Patent 5,981,517 November 9, 1999 describes new androstene derivatives with anti-inflammatory action 10. Bron AJ, Mangat H,qQuinlan M, Foley-Nolan A, Eustace P, Fsadni M, Sunder RP Polyacrylic acid in patients with dry eyes: a randomized comparison with polyvinyl alcohol Eur J Ophthalmol 1998 8(2):81-9 11. Canotoro A Ophthalmic preparation for use as artificial tears" U S Patent 5,770,628 June 23, 1998 12. Charlton JP Schwab IR Urea ophthalmic ointment and solution US Patent 5,629,344 May 13, 1997 13. Condon PI, McEwen CG, Wright M, MacKintosh G,Prescott RJ, McDonald C, "Double blind, randomized placebo controlled, crossover, multicentre study to determine the efficacy of a 0.1% (w/v) sodium hyaluronate solution (Fermavisc) in the treatment of dry eye syndrome" B J Ophthalmol 1999 83(10):1121-4 14. Conti; F Methylated chitosans and their use for the preparation of pharmaceutical compositions US Patent 4,826,826 May 2, 1989 15. Dartt DA, Donowitz M, Joshi VJ, Mathieu RS, Sharp GW Cyclic nucleotidedependent enzyme secretion in the rat lacrlimal gland J Physiol 352:375-84(1984) 16. Dikstein S Eye drops having non-Newtonian rheologicial properties US Patent 5,106,615 April 21, 1992 17. Ding S, Olejnlik O, Reis BL, " Emulsion eye drop for alleviation of dry eyes related symptoms in dry eye patients and/or contact lens wearers" US Patent 5,981,607 Nov 9, 1999 18. Domb AJ Z Ocular inserts US Patent 5,660,851 August 26, 1997 19. Egerer I , Menzel J " Eye drops" US Patent 5,434,187 July 18, 1995 20. Edelhauser et al "Corneal epithelial tight junctions and the localization of surface mucin"Adv Exp Med Biol 438:365-271(1998) 21. Foulks G " The now and future therapy of the non-Sjogrens dry eye" Advan Exp Med Biol 438: 959-964 (1998) 22. Gilbard JP, Dartt DA "Stimulation of tear secretion with cyclic nucleotides" US Patent 4,956,348 Sept 11, 1990 23. Gilbard JP Rossi,SR, Heydra KG, Dartt DA, Stimulation of tear secretionn and treatment of dry-eye disease with 3-isobytyl-1-metshyl;xanthine, Arch Ophthalmol 1991, 109(5):672-6 24. Goebbels, MJ Spitznas M Influence of various pharmaceutical agents on tear flow as assessed by fluorophotometry Adv Exp Med Biol 350: 385-891 25. Glonek; T ; Greiner; J V. ; Korb; D R US Patent 5,294,607* March 15, 1994 Dry eye treatment process and solution 26. Guo LSS Liposome composition for treating dry eye Oct 21, 1986 US Patent 4818537 27. Gokhale NS Cyanoacrylate lacrimal system occlusion after failed sac surgery" Indian J Ophthalmol 1998 46(4):253-4 28. Grant WM Toxicology of the eye 2nd ed Grant WM C.C. Thomas Springfield IL 1974) p.1073] 29. Green, K, MacKeen, DL, Slagle T and Cheeks T,, " Tear Potassium contributes to maintenance of corneal thickness" Ophthalmic Research 24: 99-102 1991 30. Greiner JV et al "Volume of the human and rabbit meibomian gland system" Adv Esp Med Bio 1998 438:339-343` 31. Gressel PD Roehrs RE Ophthalmic carboxy vinyl polymer gel for dry eye syndrome Dec 24, 1991 US Patent 5075104 32. Gunduz K and Ozdemir O "Topical cyclosporin therapy of keratoconjunctivitis sicca in secondary Sjogrens" Acta Ophthalmol (Copenh). 1994 Aug;72(4):438-42 33. Herrick; RS.; Sardi; WF Intracanalicular implant for horizontal canalicular blockade treatment of the eye U S Patent 5,053,030 October 1, 1991 34. Herrick RS, Method for treating an eye with a canalicular implant having a collapsible flared section,United States Patent 5,163,959 November 17, 1992 35. Herrick RS "Canalicular implant having a collapsible flared section and method" US Patent 5, 171,270 Dec 15, 1992 36. Hoeg AL, Meadows DL Reversible gelation emulsion compositions and methods of use US Patent 5,441,732 August 15, 1995 37. Hamano T "Dry eye treatment with eye drops that stimulate mucin production Advances Exp Med Biol 428: 965-968(1998) 38. Hamano; T; Miyata; T; Ogawara; T Method for obstructing lacrimal canaliculi with infusable solution or dispersion United States Patent 5,840,054 . November 24, 1998 39. Hutnik CM et al " Argon laser punctal therapy versus thermal cautery for the treatment of aqueous deficiency dry eye syndrome" Can J Ophthalmol 1998 33(7):365-72 40. Iga Yarisawa H, Ogane N, Saito Y, Tomizaka T, Nakagawa-Yagi, Y Masunaga H Yasuda H Miyata N, (+/=) cis-2 methylspiro[1,3 oxathiolane-5,3' quinuclidine hydrochloride, hemihydrate (SNI2011, cevimeline hydrochloride) induces saliva and tear secretions in rats and mice; the role of muscarinic acetylcholine receptors, Jpn J Pharmacol 1998 78(3):373-80 41. Itoh S Ishii Y Mukai K and Kita K Ophthalmic composition containing active Vitamin D US Patent 5,876,709 March 2, 1999 42. Joshi A, Ding S, Himmelstein KJ, Reversible gelation compositions and methods of use" US Patent 5,252,318 October 12, 1993 43. Kabra BP Patent US Patent 5,827,835 October 27, 1998 Thermally-gelling emulsions 44. Kang M-C "Ophthalmic pharmaceutical composition" Us Patent 5,698,533 Dec 16, 1997 45. Kaufman; H E Artificial tear suspension US Patent 4923700 46. Korb DR, Greiner JV, Glonek T, Whalen A,HearnSL, Esway JE,Leahy CD, " Human and rabbit lipid layer and intserference pattern observatrions" 47. Adv Exp med Biol 1998 , 438:305-308 48. Laibovits RA et al Cornea. 1993 Jul;12(4):315-23. 49. Lang,JC, Keister JC,Missel PJT, Stancioff, DJ Use of carageenins in topical ophthalmic compositions US Patent 5,403,841, April 4, 1995 50. Lemp MA Artificial tear solutions International Ophthalmol Clinic, 1973. 13(1):226-229 51. Lemp MA Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J. 1995 Oct;21(4):221-32 52. Lemp MA, "New strategies in the treatment of dry-eye states" Cornea 1999, 18(6):625-632 53. Lopez Bernal D Ubels JL " Artificial tear composition and promotion of recovery of tshe damaged corneal epithelium" Cornea 1993 12(2:115-20 54. Lubkin V US Patent 6,096,733 Aug 1, 2000 "Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application" 55. MacKeen DL and Roth HW, A method and apparatus for modulating the flow of lacrimal fluid through a punctum and associated canaliculus U.S. Patent 4,915,684, April 10, 1990 56. MacKeen, DL US Patent 5,290,572 Ophthalmic composition for treating dry eye (1994) 57. MacKeen, DL US Patent 5,366,739 Method of ophthalmic drug delivery (1994) 58. MacKeen DL Roth HW " Revolutionary method of ocular drug delivery IOVS 36(4): S166 (1995) 59. MacKeen, DL US Patent 5,595,764 Ophthalmic Composition for treating dry eye (1997) 60. MacKeen DL Roth HW and MacKeen PD, Supracutaneous treatment of dry eye patients with calcium carbonate, in Lacrimal gland , tear film and dry eye syndromes 2 Sullivan Ed. Plenum Press NY 1998 61. MacKeen, DL and Roth, HW, A preliminary report on a new method for the treatment of dry eye, Practical Optometry 6(3): 131-134 (1995) 62. MacKeen, DL, Roth, HW, Doane MA and MacKeen PD, "Supracutaneous treatment of dry eye patients with calcium carbonate, Adv.Exp. Med 438: 887-889(1998) Adv.Exp. Med 438:& Biol:985-990(1998) 63. MacKeen DL Composition for treating dry eye 5,830,508, November 3, 1998 64. MacKeen DL Ophthalmic composition for treating dry eye 5,290,572,March 12, 1994 65. MacKeen DL Method of ophthalmic drug delivery 5,366,739, November 22, 1994 66. MacKeen, DL, Roth, HW, Doane MA and MacKeen, AAF, "Investigations of a new Ophthalmic drug delivery" Eye World, 3(4):64-66 April 1998 67. Mano T Sogo S "Lacrimation accelerating agent" US Patent 5,925,677 Jul 20, 1999 68. Martin NF Robinson HN Topical composition for treatment of blepharitis US Patent 5,614,545 March 25, 1997 69. Mathers WD Lane JA, Meibomian gland lipids evaporation and tear film stability Adv Exp Med Biol 438:349-460 (1998) 70. Mauzuel C Pharmaceutical and or cosmetic composition for local use containing Rhamsan gum US Patent 4996199 Feb 26, 1991 71. McCulley JP amd Shine WE, "Meibomian secretions in chronic blepharitis" Adv Exp Med Biol 438:319-326 72. Mendius; R W. Punctum plug and method for inserting the same into the punctual opening United States Patent 6,027,470 February 22, 2000 73. Mircheff "Hormonal support of lacrimal function, primary lacrimal deficiency , autoimmunity and peripheral tolerance in the lacrimal glands "Ocular Immunol Inflam" 1996:145-172 74. Missel; P J. T. Lang; J C.; Jani; R, 5,696,166 Dec 9, 1997 U S Patent 5,212,162 ,Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions 75. Murube J Murube A Zhuo C Classification of artificial tears Advances Adv Exp Med Biol 438 705 (1998) 76. Nelson JD Drake MM Brewer JT Jr and Tuley M Evaluation of a phlkysioilogical tear substature in patiens with keratoconjunctivitis sicca Adv Exp Med Biol 350:4537 (1994) 77. Nepp J Wedrich A Akramian J Derbolov A Mudrich C Ries E Schauersberger, J Dry eye treatment with acupuncture Adv. Exp Med Biol 438:1011-1016 (1998) 78. Nepp J, Derbolov A, Haslinger-Akramian J, Mundrich C, Schauersberger J and Wedlich , Akupunctureffekt bei Keratoconjunctivitis sicca" A: Klin Monatsbl Augenheilkd. 1999 Oct;215(4):228-32] 79. Oechsneer M Keipert S " Polyacrylic acid/polyvinylpyrrolidone bipolymeric systems, 1. Rheological and mucoadhesive properties of formulations potentially useful for the treatment of dry-eye-syndrome" Eur J Pharm Biopharm 1999 47(2):113-8 80. Ogawa T, Tokushige H Watanabe N Composition for treating cornea. US Patent 5,942,487 August 24, 1999 81. Paugh, JR, Chatelier PC, Huff, JW Research['Ocular residence time of carboxymethylcellulose solutions"Adv. Exp Med Biol 438:761-768 (1998) 82. Pena N de la, Madoz SC " Patent on use of aloe vera ophthalmic solution for treatment of the dry eye syndrome, inflammations, ulcerations, alkaline or acid burns, infections and cataracts US Patent 6,013,259 Jan 11, 2000 83. Pflugfelder S "Advances in the diagnosis and management of keratoconjunctivitis sicca., Curr Opin Ophthalmol. 1998 Aug;9(4):50-3 84. Pflugfelder SC Yoshino K Tseng SCG Huang AJW Use of secretory products of human lacrimal gland acinar epithelia for tear replacement therapy US Patent 5,652,209 July 29, 1997 85. Pflugfelder SC, Tseng SCG, Huang AJW Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance (or turnover) US Patent 6,153,607 November 28, 2000 86. Py, D Patent 4,908,024, March 13, 1990 Ocular self-treatment apparatus and method 87. (cited Kass MA, Hodnapp E, Gordon M Jikjer AE Goldberg I, Patient administration of eyedrops: Observations, Part II Ann Ophthalmol 1982 14(9):889-93 88. Rumel S, Remulla H Rubin PA, Silicone punctal plug migration resulting in a dacryocystitis and canaliculitis, Cornea 1997 16(3):377-9 89. Rios JD Zoukhri D Rawe IM Hodges RR Zieske JD Dart DA Immunolocalization of muscarinic and VIP receptor subtypes and their role in stimulating goblet cell secretion IOVS 40((6):1102-1111 (1999 90. Roth HW (1998) Use of corneal thickness changes to compare the efficacy of conventional eye drops wlith supracutaneous treatment of dry eye Advances in Exp Med and Biol 438: 887 (1998) 91. Saatei AO, Irkee M and Ozguknes H, " Zinc in tears" Ophthalmic Res (1991) 31-2 92. Sall K, Stevenson OD, Mundorf TK, Reis BL Two center, randomized stukdies of the efficacy and safety of cyclosporine ophthalm emulsion in moderate to severe dry eye disease CsA phase 3 study group Ophthalmology 107(4):631-9(2000) 93. Saetonne,MF, Burgalassi S, Giannaccini B, Boldini E, Bianchini P, Luciani G, Ophthalmic solutions with tamarind seed polysaccharide US Patent 6,056,950 May 2000 94. Scheiner SA US Patent 5627611 May 6, 1997 Artificial tears 95. Schmitt P U S Patent 5469867 November 28, 1995 Cast-in place thermoplastic channel occluder 96. Schoenwald Tertiary amines with cyclopropyl adjunct will decrease sting- have antidepressant/antihypertensive actions 1998 Adv Exp Med Biol 438 p 96 97. Schoenwald RD Barfknecht CF " Ocular protein stimulants" US Patent 5,961,987 Oct 5, 1999 98. Seder; V.; Sardi; F. Lacrimal duct occluder United States Patent 4,959,048. September 25, 1990 99. Shankar AH, Prasad AS, "Zinc and immune function: the biological basis of altered resistance to infection" Am. J. Clin Nutr 1998 68(2 suppl):447S-463S 100. Smith, SG, US Patent 6,113,894 "Ophthalmic compositions and process of using" 101. Stern ME et al The pathology of dry eye: the interaction between the ocular surface and lacrimal glands, Cornea 1998 17(6):584 102. Sullivan et al "Androgens regulation of the meibomian gland" Adv Exp Med Biol 1998, 438:327-331 103. Sullivan DA Krenzer KL Sullivan BD Tolls DB Toda I Dana MR " Does androgen insufficiency cause lacrimal gland inflammation and aqueous tear deficiency?" IVOS 1999 40(6):1261-5 104. Sullivan DA Ocular treatment in keratoconjunctivitis sicca using topically applied androgen TGF beta US Patent 5,958,912 Sep 28,1999] 105. Sullivan DA Ocular treatment of keratoconjunctivitis sicca using topically applied androgens of TGF-beta US Patent 5,958,912 [2000] 106. Sullivan DA, Wickham LA, Rocha EM Krenzer KL Sullivan DA, Steagall R Cermak JM Dana MR Ullman MD Sato EH Gao J, Ono M Silveira LA Lamberts RW Kelleher RS, Tolls DB, Soda I " Androgens and dry eye in Sjogren's syndrome" Ann N Y Acad Sci 1999 876:312-24 107. Solomon A et al " The effect of a new tear substitute containing glycerol and hyaluronate on keratoconjunctivitis sicca" J Ocul Pharmacol Ther 1998 14(6):497504 108. Sullivan D "Ocular therapy in keratoconjunctivitis sicca using topically applied androgens of TGF-beta " U S patent 5,985,912 September 28, 1999 109. Tauber et al : Adv Exp Med Biol. 1998;438:969-72. "Topical cyclosporin treatment of keratoconjunctivitis sicca in secondary Sjogren's syndrome". 110. Tsubota K Monden Y Yago Y GotoE Shimmura S "New treatment of dry eye: the effect of calcium ointment through eyelid skin delivery" Br J Ophthalmol 1999, 83(7):767-70 111. Tsubota, K, Goto E, Shimmura S, Shimazaki J, Treatment of persistent corneal epithelial defect by autologus serum appllication Ophthalmology 106(10) 1984-9 (1999) 112. Tsubota K "Tear dynamic and dry eye" Prog Retin Eye Res 17(4):565-96 113. Tsubota K, Goto E, Shimmura S, Shimazaki J " Treatment of persistent corneal epithelial defect by autologous serum application" Ophthalmology 1999 106(10):1984-9 114. Tsybota K [2000] 115. Tsubota K Drug composition comprising albumin as the active ingredient US Patent 6,043,213 Mar 28, 2000 116. Tsubota K Pharmaceutical composition comprising albumin as an active ingredient US Patent 6,159,930 Dec 12, 2000 117. Tui VV Grounauer PA Portable device for programmable automatic, or ondemand delivery of artificial tears, Adv Exp Med Biol 438: 1027 (1998) 118. Vo; Van T. December 15, 1992 US Patent 5,171,306 Eyedrop delivery system 119. Watanabe H, Fabricant M, Tisdale AS, Spourr-M<ichaud, SJ, Lindberg K, Gipson IK Human corneal and conjunctival epithelia produce a mucin-like glycoprotein for the apical surface IOVS 19995, 36(2):337-41 120. Wilson CG et al " Ocular contact time of a carbomere gel (GelTears) in humans" Br J Ophthalmol 1998 82(10):1131-4 121. Webb; N J Punctum plug United States Patent 6,016,806 Webb January 25, 2000 122. Wilson SE Liang Q Kim WJ Lacrimal gland HGF, KGF and EGF mRNA levels increase after corneal epithelial wounding, IOVS 40(10)2185-2190 1999 123. Wilson SE, Li Q, Mohan RR,Tervo T,Vesaluoma M, Bennett GL, Schwall R, 124. Tabor K, Kim J, Hargrave S, Cuevas, KH " Lacrimal gland growth factors and receptors:lacrimal fibrolbatic cells are a sourece of tear HGF, Ad Exp Med Biol 438:625-628 (1998) 125. Yanni JM, Gamache, DA, Miller ST " compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders" US Patent 5,696,166 Dec 9, 1997 126. Yerxa,BR Jacobus Km, Pendergast W, Rideout JL 1997 US Patent 5,900,407 Method of treating dry eye disease by stimulating fluid secretion with the topical administration of uridine triphosphates and related compounds, May 4, `1999