non invasive detection of bladder cancer at 465 mhz

F. Esperto, C. De Nunzio, C. Kastner , A. Tubaro (Roma, Italia )
Aim of the study
The objective of this study was to evaluate the diagnostic accuracy of bladder cancer detection
using the TRIMprob, a nonlinear tuneable oscillator generating extremely low energy multiple
electromagnetic fields.
Materials and methods
200 consecutive patients referred to our outpatients clinic for urethrocystoscopy were enrolled in
the study. All patients were investigated by history, physical examination, urinalysis, urine
culture and urine cytology, urethrocystoscopy and TRIMprob test. Transurethral resection of the
bladder was performed in case of any suspicious lesion. Main indications for cystoscopy were
gross haematuria and follow-up of patients after TURB. Patients affected by pelvic tumors,
urinary tract infection, with cardiac pacemakers or other electromagnetic devices were excluded
from the study. The TRIMprob was moved over the surface of the patient’s pubic region while
standing in front of the system receiver in two different positions, with a bladder filling of 150
ml after endoscopic examination. Two operators blinded to the patient status independently
conducted the test from January 2008 to October 2010. Nonlinear resonance was analyzed at
465, 930 and 1395 MHz.
Analysis of resonance values at 465MHz showed a statistically significant difference between
patients with and without bladder cancer (p
The TRIMprob device opened a new perspective in the management of bladder cancer, but a new
culture and a new language must be developed to fully exploit its possibility.
In our experience the TRIMprob has a high diagnostic accuracy for the diagnosis of bladder
cancer and has a great potential clinical value in Urology.