Biographical Sketch - University of Mississippi Medical Center

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BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Heather Anne Drummond
Associate Professor
Department of Physiology and Biophysics
eRA COMMONS USER NAME
hdrummond
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as
nursing, and include postdoctoral training.)
DEGREE
INSTITUTION AND LOCATION
(if
YEAR(s)
FIELD OF STUDY
applicable)
California State Univ. Hayward, Hayward, CA
B.S.
1983-1987
Human Performance
University of Arizona, Tucson, AZ
M.S.
1988-1990
Exercise Physiology
Medical College of Wisconsin, Milwaukee, WI
Ph.D
1990-1996
Physiology
A. Personal Statement
Dr. Drummond is an Associate Professor in the Department of Physiology and Director of the Confocal Core
Facility at the University of Mississippi Medical Center, which includes a Leica TCS SP2 Confocal
Microscope and Leica TCS SP5 Multiphoton Confocal Microscope. She has 20 years of expertise in
fluorescence imaging. She is internationally recognized for her pioneering research for the role of Epithelial
Na+ Channel/Acid Sensitive Ion Channel (ENaC/ASIC) protein family in vascular function. Dr. Drummond’s
laboratory was the first lab to establish the putative mechanosensitive ENaC/ASIC protein expression in
vascular smooth muscle cells and their role in migration, pressure-induced constriction and blood flow
autoregulation. Furthermore, her laboratory was the first to demonstrate the presence of degenerin
mediated proton-gated and mechanically gated ionic currents in vascular cells.
B. Positions and Honors.
Positions and Employment
1996-2000
Post-Doctoral Fellow, Department of Internal Medicine, College of Medicine, University of
Iowa, Iowa City, IA.
2000-2001
Assistant Research Scientist, Department of Internal Medicine, College of Medicine,
University of Iowa, IA.
2001-2008
Assistant Professor, Department of Physiology and Biophysics, University of Mississippi
Medical Center, Jackson, MS.
2008- current Associate Professor, Department of Physiology and Biophysics, University of Mississippi
Medical Center, Jackson, MS.
Honors and Awards
1994 Procter and Gamble Professional Opportunity Award, American Physiological Society
1996-1997
Post-Doctoral Fellowship, Institutional NRSA, University of Iowa
1997-1999
Post-Doctoral Fellowship, Individual NRSA, University of Iowa
1998 Young Investigator Travel Award, International Society of Hypertension
1998 Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award, APS
1999-2000 Post-Doctoral Fellowship, Institutional NRSA, University of Iowa
2002 Bronze Award, University of Mississippi Faculty Achievement Award
2005 Gold Award, University of Mississippi Faculty Achievement Award
2006 Ad hoc reviewer for National Institutes of Health
2006 Ad hoc reviewer for Canadian Research Council
2006 – Pr Editorial Board Am J Physiol Renal
2008 American Society for Hypertension, Young Investigator Award
C. Selected peer-reviewed publications.
1. Jernigan NJ and HA Drummond. Myogenic vasoconstriction in mouse renal interlobar arteries: role of
endogenous and NaC. American Journal of Physiology-Renal Physiology, 291:F1184-F119, 2006.
2. Grifoni SC, Gannon KP, Stec DE and HA Drummond. ENaC proteins contribute to VSMC migration.
American Journal of Physiology-Heart and Circulatory Physiology. 291(6):H3076-86, 2006.
3. Drummond HA, Jernigan NL, Grifoni SC. Sensing tension: ENaC/ASIC proteins in cardiovascular
homeostasis. Hypertension. 2008 May;51(5):1265-71.
4. Jernigan NL, LaMarca BB, Speed J, Galmiche L, Granger J, HA Drummond. Dietary salt enhances
benzamil sensitive component of myogenic constriction in mesenteric arteries. Am J Physiol Heart Circ
Physiol. 294(1):H409-20, 2008. PMID: 18024548.
5. Drummond HA, Grifoni SC and NL Jernigan. A new trick for an old dogma: ENaC proteins as
mechanotransducers in smooth muscle. Physiology. Feb 23: 23 – 31, 2008
6. Grifoni SC, McKey SE, HA Drummond. Hsc70 regulates cell surface ASIC2 expression and vascular
smooth muscle cell migration. Am. J. of Physiol Heart Circ Physiol. 294(5):H2022-30, 2008.
7. Gannon KP, Vanlandingham LG, Jernigan NJ, Grifoni SC, HA Drummond. Impaired pressure induced
constriction in cerebral arteries of ASIC2 knockout mice. Am. J of Physiol Heart Circ Physiol,
294(4):H1793-803, 2008.
8. Jernigan NJ, Speed J, LaMarca BB, Granger JP, Drummond HA. Angiotensin II regulation of renal vascular
ENaC proteins. American Journal of Hypertension. Jun;22(6):593-7, 2009. PMCID: PMC2787100
9. VanLandingham LG, Gannon KP, Drummond HA. Pressure-induced constriction is inhibited in a mouse
model of reduced bENaC. Am J Physiol Regulatory. 297(3):R723-8. 2009. PMCID: 2739788
10.Grifoni SC, Chiposi R, McKey SE, Ryan MJ, Drummond HA. Altered whole kidney blood flow autoregulation
in a mouse model of reduced ENaC. .Am J Physiol Renal Physiol. 2010 Feb;298(2):F285-92. PMCID:
PMC2822522.
11. Chung WS, Farley J, Swenson A, Chiposi R, Barnard JM, Drummond HA. Extracellular acidosis activates
ASIC-like channels in freshly dissociated cerebral VSMCs. Am J Physiol Cell Physiol, 298(5):C1198-208,
2010. PMID: 20181928
12. Chung WS, Farley JM, Drummond HA. ASIC-like currents in cerebral artery vascular smooth muscle cells
are inhibited by endogenous oxidase activity. Cellular Physiology and Biochemistry. 27(2):129-38, 2011.
PMID: 20181928.
13. Drummond HA, Grifoni SC, Abu-Zaid A, Gousset M, Chiposi R, Barnard M, Murphey B, Stec DE. Renal
inflammation and elevated blood pressure in a mouse model of reduced ENaC. American Journal of
Physiology Renal Physiology. Am J Physiol Renal Physiol. Aug;301(2):F443-9, 2011. PMID: 21543417
14. Ge Y, Gannon K, Gousset M, Liu R, Murphey B, Drummond HA. Impaired myogenic constriction of the
renal afferent arteriole in a mouse model of reduced βENaC expression. Am J Physiol Renal Physiol. 2012
Jun 1;302(11):F1486-93. PMID: 22419697.
15. Chung,WS, Weissman, JL, Farley J, and Drummond, HA. ENaC is required for whole-cell mechanicallygated currents in renal vascular smooth muscle cells. Am J Physiol Renal Physiol. 304(12):F1428-37,
2013. PMID: 23552864
D. Research Support.
Ongoing Research Support
P01-HL51971
Hall (PI)
01/1/09-12/31/13
NIH/NHLBI
"Cardiovascular dynamics and their control”
Project II of the proposal seeks to determine the role of angiogenic and endothelial factors in the
pathophysiology of pregnancy-induced hypertension.
Role: Co-Investigator
NIH Shared Instrumentation Grant RR031728
“TCS SP5 Multiphoton Confocal Microscope”
4/1/2012 – 3/31/2013
Score: 15%
Role: Principal Investigator
Pending
R01 NHLBI Drummond (PI)
7/1/013 – 6/30/17
Degenerin proteins in
$375,000
The goal of this study is to determine if ASIC2 mediated myogenic constriction contributes to renal
autoregulation and protects the kidney from pressure-related injury.
Role: Principal Investigator
R01 NHLBI Ryan, Drummond and Granger (Co-PI)
7/1/013 – 6/30/17
Hypertension and vascular function during placental ischemia $375,000
The goal of this study is to determine if TNFalpha mediated inhibition of bENaC constributes to loss of
myogenic constriction and autoregulation of cerebral vessels and blood flowduring placental ischemia.
Role: Co-Principal Investigator
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