Introduction It is essential for us that authors write and prepare their manuscripts according to the instructions and specifications listed below. The length and effectiveness of the peer review process will largely depend upon the care used by authors in preparing their manuscripts. Therefore, contributors are strongly encouraged to read these instructions carefully before preparing a manuscript for submission, and to check the manuscript for conformance before submitting it for publication. Manuscripts preferred for publication in the CEJMed are those which: contain original work - which is not published elsewhere in any medium by the authors or anyone else, and is not under consideration for publication in any other medium. This restriction does not apply to review articles are focused on the core aims and scope of the journal - the CEJMed is a scientific journal publishing research results from all fields of medicine are clearly and correctly written - should contain all essential features of a complete scientific paper, should be written in a clear, easy to understand manner, and be readable for a wide audience of medical professionals are written in English - should be clearly and grammatically written, in an easily readable style. Attention to detail of the language will avoid severe misunderstandings which might lead to rejection of the paper (Please note that authors who are not native-speakers of English can be provided with help in rewriting their contribution in correct English) text is a double-spaced, with font size no less than 12 are delivered in electronic format Manuscripts along with the covering letter should be submitted via Editool. In special situation, if any technical problems occurred, it can be emailed directly to the Managing Editor of the Central European Journal of Medicine (Inga Markiewicz, imarkiewicz@versita.com). Organization of the manuscript Paper elements: 1. title page with: 1.1. title (running title) 1.2. complete name(s) of author(s) 1.3. name and address of workplace(s) 1.4. personal e-mail address(es) 2. abstract 3. keywords 4. text 4.1 introduction 4.2 materials and methods 4.3 statistical methods and experimental procedures 4.4 results 4.5 discussion 4.6 acknowledgments (if applicable) 4.7 references 5. footnotes/endnotes 6. table and figure legend 7. tables 8. figures 9. supplemental data (if applicable) 10. multimedia and images (if applicable) Each of these elements is detailed below 1.1. Title (short title) We suggest the title should be as short, informative and comprehensible for a broad scientific audience as possible. If a long title is necessary, please prepare an optional short title. It should not contain non-standard acronyms or abbreviations. We emphasize, that it is the title, which usually should convey to a broad scientific readership. 1.2. Name(s) of author(s) A list of all authors of the paper should be prepared. We need full first name, initial(s) for middle name(s) and full last name. 1.3. Name and address of workplace(s) Authors' affiliations should be indicated in this section. Affiliation(s) should include: Department University/ Organization Address: country, city, state/province (if applicable), postal code, street 1.4. Personal e-mail address(es) At least one, valid, e-mail address is needed. It will be used as the corresponding author's email address in all contacts with the authors. 2. Abstract An abstract must accompany every article. It should be a brief summary of the significant items of the main paper. An abstract should give concise information about the content of the core idea of your paper and clearly describe the major findings reported in the manuscript. It should be informative and not only present the general scope of the paper but also indicate the main results and conclusions. An abstract should not normally exceed 200 words. It should not contain literature citations or allusions to the tables or illustrations. All non-standard symbols and abbreviations should be defined. In combination with the title and keywords, the abstract is an indicator of the content of the paper. Authors should remember that online systems rely heavily on the content of titles and abstracts to identify articles in electronic bibliographic databases and search engines. They are therefore requested to take great care in preparing these elements. Image or illustration accompanying abstract Authors are invited to submit scientifically interesting and visually arresting image or illustration being representative of the work. We strongly encourage enclosing the image or illustration (including photo, graph, scheme or others) referring the subject reported in the manuscript. The image or illustration could originate from the experimental findings reported in the manuscript but does not has to constitute a part of the original work and need not be reprinted in the article. The image or illustration could stay authors-choice but still corresponding to the general idea of their manuscript. All images or illustrations must be original and submit as a separate file. 3. Keywords List of all keywords (at least 3) proposed by the authors, separated by commas or semicolons. It is obligatory part of the manuscript. 4. Text General rules for writing use simple and declarative sentences; avoid long sentences, in which the meaning may be lost by complicated construction be concise, avoid idle words make your argumentation complete; use commonly understood terms; define all non-standard symbols and abbreviations when you introduce them explain all acronyms and abbreviations when they first appear in the text use all units consistently throughout the article be self-critical as you review your drafts the text should be double-spaced, with font size no less than 12 Structure of a paper Research papers and review articles should follow a strict structure following typical requirements for scientific publications. 4.1 Introduction Indicates the scope of the subject and presents the purpose of the studies reported. Introduction should clearly show the studies reported relationship to earlier work in the field, while avoiding being an extensive review of the literature. The introduction should provide the hypothesis that was addressed and the rationale for present study. 4.2 Materials and methods If the article is research one it should contain section were clinical characteristics of the patients is presented. Here also all used methods should be described. 4.3 Statistical methods and Experimental Procedures This section should contain sufficient detail to enable others to repeat the authors' work. The statistical methods should be described in a precise way to permit verification of the reported results. Previously published procedures should be cited in References and only truly new procedures or modifications of formerly published procedures should be described in details. In theoretical papers comprising the computational analysis, technical details such as computational methods and models applied or newly developed models should be provided to enable readers to reproduce the calculations. 4.4 Results This section should include the results of the experiments. Results could be presented in figures and tables. Results not requiring documentation given solely in the text. Please take under consideration that Result section should not consists of an extensive interpretation of the results, which is reserved for discussion. 4.5 Discussion Discuss all important elements of your scientific findings. The Discussion should be focused on the interpretation of the results and should confront the results of other investigations especially those quoted in the text. Authors are requested to avoid a repetition of the Results section in the discussion section. 4.6 Acknowledgements This section consists acknowledgements of the assistance of colleagues or similar notes of appreciation, as well as information concerning any financial support received for the work being published. 4.7 References Because all references will be linked electronically to the papers they cite, proper formatting of the references is crucial. A complete reference should give the reader enough information to find the relevant article. It is required to pay particular attention to spelling, capitalization and punctuation. 1. References to unpublished or submitted work, unpublished conference presentations, personal communications, patent applications and patents pending, computer software, databases, and websites should be referred to as such only in the body of the text. These should be kept to the minimum. The examples are as follows: (J. Smith, unpublished data) (J. Smith and P. Brown, submitted for publication). (J. Smith, personal communication) (J. Smith and P. Brown, presented at the Fourth Symposium on Virology and Microbiology, Overton, IL, 13 to 15 June 1999) (J. C. Coldwell, April 1970. Process for health promotion. U.S. patent 484,363,770) (J. Smith, 20 June 1999, Australian Patent Office) ... available in the GenBank database (http://www.ncbi.nlm.nih.gov/Genbank/index.html). ... using ABC software (version 2.2; Department of Microbiology, State University [http://www.stu.micro]). 2. Published or accepted ('in press') manuscripts, books and book chapters, theses should be included in the reference list. References to published meetings abstracts should be kept to the minimum. The title of the article must be included. For all references, list all authors if there are less then six or the first six authors and add "et al." if there are additional authors. Standard abbreviations of journal names according to Thomson Scientific should be used (see: Journal Abbreviations ). Please use the following style for the reference list: Published Papers Kulig P., Zabel B.A., Dubin G., Allen S.J., Ohyama T., Potempa J., et al., Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin, J. Immunol., 2007, 178, 3713-3720 Kowalski J., Franczewski K., Potempa J. Stafopaina B Staphylococcus aureus, aktywator chemeryny osoczowej, Immunol. Pol., 2007, 178, 37133720, (in Polish) Accepted Papers Kulig P., Zabel B.A., Dubin G., Allen S.J., Ohyama T., Potempa J., et al., Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin, J. Immunol., (in press), DOI Kowalski J., Franczewski K., Dubin G., Allen S.J., Ohyama T., Potempa J., et al., Stafopaina B Staphylococcus aureus, aktywator chemeryny osoczowej, Immunol. Pol., (in press, in Polish), DOI: 10.1039/b724418m Electronic Journal Articles Dionne M. S., Schneider D. S., Screening the human immune system, Hum. Genetics, 2002, http://humangenetics.com/2002/3/4/reviews/1010 Books and book chapters Sambrook J., Russell D.W., Molecular cloning - a laboratory manual, 3rd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 2001 Sambrook J., Cloning and sequencing, In: Sambrook J., Russell D.W. (Eds.), Molecular cloning - a laboratory manual, 3rd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 2001 Theses Agutter A.J., Natriuretic peptides, PhD thesis, Edinburgh University, Edinburgh, UK, 1995 Gutrowski A., Peptydy natriuretyczne, PhD thesis, Medical University of Warsaw, Warsaw, Poland, 2005, (in Polish) Conference proceedings Malarski J, Fratyk D., Kubiszewski B., Banaszak J., Reference style guide, In: H. Janus (Ed.), Proceedings of ME Conference (11-13 July 2007, Warszawa, Poland), Versita Warsaw, 2007, 1335-1791 Newspaper articles A. Sherwin, Heart Failure, The Times, 13 July 2007, 1-2 M. Dzierżanowski, Niewydolność serca, Wprost, 8 July 2007, 18 (in Polish) References are listed and numbered in the order that they appear in the text. In the text, citations should be indicated by the reference number in brackets. Multiple citations within a single set of brackets should be separated by commas. Where there are more than three sequential citations, they should be given as a range. Example: "...has been shown previously [1,4-6,22]." Figure captions and tables should be at the end of the manuscript. Before submitting your article, please make sure you have carefully checked the manuscript for any relevant references you may have missed. 5. Footnotes/Endnotes We encourage authors to restrict the use of footnotes. If necessary, please make endnotes rather than footnotes. Allowable footnotes/endnotes may include: the designation of the corresponding author of the paper the current address of an author (if different from that shown in the affiliation) abbreviations and acronyms traditional footnote content 6. Legend of tables and figures Should contain sufficient details to make the table or figure easily understood, thus be as explanatory as possible. 7. Tables Authors should use tables only to achieve concise presentation, or where the information cannot be given satisfactorily in other ways. Tables should be numbered consecutively using Arabic numerals and referred to in the text by number. Each table should have an explanatory caption which should be as concise as possible. 8. Figures Authors may use line diagrams and photographs to illustrate theses from their text. The figures should be clear, easy to read and of good quality. Styles and fonts should match those in the main body of the article. All figures must be mentioned in the text in consecutive order and be numbered with Arabic numerals. We accept submission of text and figures as separate files or as a composited pdf file. Authors should indicate precisely in the main text where table/figures/schemes should be inserted. 9. Supplemental data Authors can also submit any data files and additional figures in attachments. These elements can be submitted in any of the usual formats (PDF, MS Word, TeX, GIF, TIFF, etc.). It is possible that we may not be able to open your data files. To prevent any misunderstandings we request that authors submit a text file (instruction.txt) containing brief instructions on how to use the attached files. 10. Multimedia and images Authors can attach files in most popular formats, including (for example): images in BMP, GIF, JPEG formats, which authors willing to attach to the main text and which do not belong to the regular Results section and are not indispensable for general paper understamding. multimedia files in MPEG or AVI formats. However please keep to file types that are read by standard media players (e.g. RealPlayer, Quicktime, Windows Media Player) and/or standard office applications (Adobe Acrobat Reader, Microsoft Office etc.). Your attachments may be accessible through links to external locations or to our internal locations (if you choose the second option, please remember to send us your attachments). We encourage enclosing one image of the author's choosing per video. This image will act as a link from the text to the full video file. Please indicate clearly in your text whether a figure has a video associated with it and be sure to indicate the name of the corresponding video file. A brief legend should also be provided. Please remember that your images, video and animation clips are intended for internet use and we need to consider the needs of users with slow internet connections. Please try to minimize file sizes by using a lower resolution or number of colors for images and animations (as long as the material is still clear). To help you in formatting your images (including tables and figures) or multimedia files, please submit your paper with separate attachments, which are used in your paper. Nomenclature Measurements of length, height, weight, and volume should be reported in metric units or their decimal multiples. All hematological and clinical chemistry measurements should be reported in the metric system in terms of the International System of Units (SI). Abbreviations and symbols Please use only standard abbreviations. They should be explained when first time used in the text. Avoid abbreviations in the title and abstract. Authorization for the use of experimental animals or human subjects The use of human subjects or other animals for research purposes is regulated by the federal government and individual institutions. All experiments on live vertebrates or higher invertebrates must be performed in accordance with these relevant institutional and national guidelines and regulations. Manuscripts containing information related to human or animal use should clearly state that the research has complied with all relevant national guidelines and institutional policies. Copies of these guidelines and policy statements must be available for review by the Editor if necessary. For manuscripts reporting experiments on human subjects, the policy of committee (Bioethics Committee) approving the experiments and a statement confirming that informed consent was obtained from all subjects must also be available for review by the Editor if necessary. We remind not to use patients' names neither hospital unit numbers as a part of designation, when isolates were derived from patients in clinical studies. All human and animal studies must have been approved by the investigator's appropriate Institutional Review Board. The editors reserve the right to seek additional information or guidance from reviewers on any cases in which concerns arise. Submission formats Manuscripts for the CEJMed can be submitted in the following formats: MS Word (97 or higher) either as standard DOCUMENT (.doc) or RICH TEXT FORMAT (.rtf) HTML TXT Authors may also upload (additionally) a PDF file. Style files and templates We are about to provide an access to a template file in MS Word format according to Springer specifications, which may be useful for authors in preparing their manuscripts in CEJMed layout.