prepared 2/1/2009
CURRICULUM VITAE
Name:
Jia-huai Wang
Address:
81 Alexander Avenue, Belmont, MA 02478
Place of birth:
Shanghai, China
Date of birth:
March 19, 1941
Education:
1963 B.S.
1979 Ph.D.
University of Science & Technology of China, Beijing, China
Institute of Biophysics, Chinese Academy of Sciences, Beijing
Post-doctoral Training:
1979-1981
1981-1982
Visiting Scholar, Department of Biochemistry, University of Wisconsin,
Madison, WI
Visiting Scholar, Department of Biochemistry & Molecular Biology,
Harvard University, Cambridge, MA
Academic Appointments:
1979-1986
1986-1988
1988-1990
1990-1995
1996-2001
1996-2001
20012001-
Assistant Professor, Institute of Biophysics, Chinese Academy of
Sciences
Associate Professor, Institute of Biophysics, Chinese Academy of
Sciences
Professor, Institute of Biophysics, Chinese Academy of Sciences
Research Associate, Department of Biochemistry & Molecular Biology,
Harvard University, Cambridge, MA
Principal Scientific Associate in Medicine, Laboratory of Immunobiology
and X-ray Crystallography Unit, Dana-Farber Cancer Institute, Harvard
Medical School, Boston, MA
Lecturer in Pediatrics, Children's Hospital, Harvard Medical School
Associate Professor of Pediatrics (BCMP), Harvard Medical School
Associate Professor, Dana-Farber Cancer Institute
Institute Appointments:
1984-1987
1987-1990
Vice-director, Department of Protein Crystallography, Institute of
Biophysics, Chinese Academy of Sciences
Director, Department of Protein Crystallography, Institute of Biophysics,
Chinese Academy of Sciences
Awards and Honors:
1982
1987
Natural Science Award of China
Outstanding Scientist, awarded by State Council of China
Editorial Boards:
1997-
Member on the editorial board for “Macromolecular Structure Pre-90”
Chief editor: Wayne Hendrickson, asssociate editors: Jan Drenth and
Kurt Wuthrich, Publisher: Current Biology Ltd., London, UK.
Memberships in Professional Societies:
1978-1991
199019931993-2000
19972007-
Chinese Biophysics Association
American Association for the Advancement of Science
Society of Chinese Bioscientists in America
New York Academy of Sciences
Ray Wu society, USA
American Crystallographic Association
Committee Assignments:
1987-1990
1987-1990
National 863 Committee of Biotechnology, China
Committee of Biotechnology, Chinese Academy of Sciences
1997
2005-2010
Allergy, Immunology, and Transplantation Research Committee of NIAID
Scientific Advisory Committee, Structural Biology Center, Argonne
National Laboratories
Ad Hoc member of NIAID’s Board of Scientific Counselors
2007.12
Major Research Interests:
1.
2.
3.
4.
Structure, function and evolution of immunoglobulin superfamily proteins from immune
and neuronal systems.
Structure and function of other cell adhesion receptors.
Structural studies of viral proteins of HIV and flu and drug design
Structural studies on virus receptors and their complexes with viral surface proteins
Teaching Experience:
1982-1988 Lectures on "Principles of protein structures", course in Molecular Biology
Chinese Academy of Sciences Graduate School, 10 lectures per year, China
20032007 BCMP201: “Proteins: Structure, Function and catalysis”, Harvard Medical
School, BBS graduate course, Discussion leader.
List of former trainees who become principal investigators:
1983-1985 Master degree trainee: Zi-he Rao, now the President of Nankai University, China
and a professor in the School of Life Sciences, Tsinghua University, Beijing,
China
1983-1986 Master degree trainee: Wen-qing Xu, now a professor in University of
Washington, School of Medicine. Seattle, WA
1985-1989 Post-master trainee: Xue-jung Zhang, now an associate professor in University
Of Oklahoma, Medical Research Foundation, Oklahoma city, OK
1995-1998 Postdoctor trainee (co-adviser with Timothy Springer): Jose Casasvonas, now a
principal investigator at Centro Nacional de Biotecnologia, CSIC, Campus
Universidad Autonoma, Spain
2001-2006 Postdoctor trainee (co-adviser with Timothy Springer): Can Xiao, now a principal
investigator at NIAID, NIH
2001-2006 Postdoctor trainee: Rob Meijers, now a principal investigator at PROXIMA II
beamline at Soleil Saint Aubin, France
2004-2008 Postdoctor trainee: Hongmin Zhang, now an assistant professor at Hong Kong
University, Hong Kong, China
Lectures:
1986
1986
1986
1986
1987
1988
1988
1989
1989
1990
1990
1991
1991
1992
1993
1993
1993
"Trichosanthin: From Chinese herb medicine to ribosome inactivating
protein", Oxford University, Lab. of Molecular Biophysics, Oxford, UK
"Trichosanthin: ...", Birkbeck College, Dept. of Crystallography,
London, UK
"Trichosanthin:...", Imperial College, The Blacket Lab., London, UK
"Trichosanthin: ...", Univ. of Gröningen, Dept. of Chemistry,
Gröningen, The Netherlands
"Three dimensional structure of protein and nucleic acid", Intl. Society
of Biophysics summer course, Beijing, China
"Trichosanthin: ...", Chinese Univ. of Hong Kong, Dept. of Biochemistry,
Hong Kong
"Trichosanthin: ...", Forum by International Center for Biotechnology,
Trieste, Italy
"Trichosanthin: ...", Univ. of Oregon, Inst. of Molecular Biology,
Eugene, OR
"Trichosanthin: ...", Max-Planck Inst. für Biochemie, Munich, Germany
"Crystal structure of N-terminal two domain fragment of CD4 and its biological implication", Purdue Univ, Dept. of Biological Sciences, W. Lafayette, IN
"Crystal structure of N-terminal...", Ohio State Univ, Center for Biotechnology, Columbus, OH
"Crystal structure of N-terminal...", Boston Univ., Biophysics Program,
Boston, MA
"Crystal structure of N-terminal...", NIH, Bethesda, MD
"Crystal structure of N-terminal...", Univ. of Pennsylvania, Dept. of
Biochemistry & Biophysics, Philadelphia, PA
"Structural studies of CD4: How it is subverted to be the receptor for HIV"
Najing University, Nanjing, China
"Structure, Function and Evolution of CD4", Conference of Chinese
Bioscientists in America, Baltimore, MD
"Structure of HIV receptor-CD4", Intl. Congress of Crystallography,
Beijing, China
1994
1995
1995
1995
1995
1995
1996
1997
1997
1997
1999
2000
2000
2001
2001
2002
2003
2003
2004
2004
2004
2005
2006
2006
2006
2006
"Crystal structure of N-terminal...", Univ. of Virginia, Dept. of Molecular
Physiology & Biological Physics
"Crystal structure of N-terminal two domain fragment of VCAM-1: A
cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1/ a4
interaction", 6th Intl. Symp. of Chinese Bioscientists in America, Vancouver, BC
"Crystal structure of VCAM-1, the comparison to that of CD4",
LeukoSite Inc., Boston, MA
"Crystal structure of VCAM-1...", Dana-Farber Cancer Institute
"Crystal structure of VCAM-1...", Center for Blood Research, Harvard
Medical School, Boston, MA
"Crystal structure of VCAM-1...", Fuji Immunopharmaceutical Inc.,
Boston, MA
“The crystal structure of ICAM-2, its comparison to other integrin-binding
proteins”. 17th Intl. Congress of Crystallography, Seattle, WA
“The crystal structure of ICAM-2 reveals presentation of a distinctive
integrin recognition surface”, Gordon Research Conferences, Ventura, CA
“Structure of a complex of T-cell receptor and Fab”, 7th Intl. Symp. of
Chinese Bioscientists in America, Toronto, Canada
“Crystal structures of Ig superfamily proteins as integrin ligands”
37th American Society for Cell Biology Annual Meeting, Washington, DC
“Structure of a heterophilic adhesion complex between the human CD2 and
CD58 (LFA-3)” 18th Intl. Congress of Crystllography, Glasgow, UK
“Structures of antigen specific and non-specific immune receptor complexes”
Federation of American Society of Experimental Biology, Summer Research
Conference 2000, Saxtons River, MT
“Structural basis of immune recognition”, Lecture in plenary session of 15th
conference of Federation of Asian and Oceanian Biochemistry and Molecular
Biologists, Beijing, China
“Protein recognition on cell surface”, The 1st Tsinghua International Conference
on Protein Science, Beijing, China
“Structural basis of cellular immunity”, The Fragrant Hill meeting on immunology,
Beijing, China
“What makes a virus receptor: A structural perspective”, The Novum Lecture,
Karolinska Institute, Stockholm, Sweden
Molecular mechanism of cell adhesion: Structural perspective”, McGill University
Medical Center, Montreal, Canada
“Molecular structure of ICAM-1 ecto-fragment and its implicated role in
immunological synapse function”, Gordon Research Conferences, Ventura, CA
“Atomic resolution views of the immunological synapse National Jewish Medical
and Research Center and School Of Medicine, UCHSC, Denver, CO
“Molecular mechanism of cell adhesion”, International symposium on mechanism
of cell adhesion. Iksan, South Korea
“Atomic resolution view of immunological synapse”, 10th International symposium
of The Society of Chinese Bioscientists in America. Beijing, China
“Molecular mechanism of cell-cell interaction in immune system”, 2005 FASEB
Summer Research Conference: Immunoreceptors, Tucson, AZ
“Molecular basis of cellular immunity”, Chinese University of Hong Kong
“Structure and bi-functionality of Dscam headpiece: One stone for two birds”.
Annual meeting of American Crystallography Association, July 06, Hawaii
Two lectures at the summer school on structural biology of China: 1) “Structural
immunology”; 2) “Structural perspective of viral infection”, Hefei, China
“Structure and bi-functionality of Dscam headpiece: One stone for two birds”.
2006
2007
2007
2007.10
2007.11
2008.6.
2008.6
2008.7
2008.8.
2009.1
UCLA, Department of Biological Chemistry, Los Angeles, CA. 90095
Lectures of “X-ray crystallography”, an informal mini-course at Dana-Farber for
postdoctoral fellows, Boston, MA.
“Structure of Dscam reveals its dual function in nervous and immune systems”
University of Washington, Department of Biochemistry, Seattle, WA.
“Structure and function of Dscam: One stone for two birds”. Harvard Medical
School-Beijing Biophysics Institute Bilateral Conference on Structural Biology,
2007, Beijing, China (I am the co-organizer)
“What determines the binding affinity of CD8—Structural perspective”
International CD8 Group conference, Amherst, MA.
“Virus/host cell interaction: From structure to medical implication”. School of Life
Sciences, Beijing University, Beijing, and Fudan Medical School, Shanghai,
China
“Decoding recognition specificity of Dscam, a neural receptor with thousands
isoforms”, MRC National Institute for Medical Research, London, UK.
“Decoding recognition specificity of Dscam, a neural receptor with thousands
isoforms”, Oxford University, UK.
“Unique features of protein-protein interaction on cell surface”, The 2nd
International Conference on Molecular Aspects on Protein-Protein Interaction,
Dubrovnik, Croatia.
“Decoding recognition specificity of Dscam, a neural receptor with thousands
isoforms”, 21st International Congress of Crystallography, Osaka, Japan.
“Protein-protein interaction on cell surface”, The Scripps Institute, Lo Jolla, CA.
Bibliography:
Original reports:
1.
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2:148-150.
2.
Beijing Insulin Structure Research Group. Studies on crystal structure of insulin at 2.5Å.
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Beijing Insulin Structure Research Group. Studies on the insulin crytsal structure: The
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Wu BM, Wang JH. X-ray studies on two kinds of fibrous proteins from a cadaver
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Stuart D, Dai JB, Lou MZ, You JM, Todd R, Li JY, Wang JH, Liang DC. X-ray studies on
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Wang JH. The major groove of B-DNA is the best binding site for the recognition helix
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Pan KZ et al. The three dimensional structure of trichosanthin molecule.
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Karpusas M, Hsu YM, Wang JH, Thompson J, Lederman S, Chess L, Thomas D. 2Å
crystal structure of an extracellular fragment of human CD40 ligand. Structure 1995;
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20.
Wang JH, Stehle T, Pepinsky RB, Liu JH, Karpusas M, Osborn L. The crystal structure
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Tan K, Casasnovas JM, Liu J-H, Briskin MJ, Springer TA, Wang J-H. The structure of
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important for integrin recognition. Structure. 1998; 6:793-801.
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Ghendler Y, Teng M-K, Liu J-H, Witte T, Liu J, Kim KS, Kern P, Chang H-C, Wang J-H,
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Kern PS, Teng M-K, Smolyar A, Liu J-H, Liu J, Hussey RE, Spoerl R, Chang H-C,
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crystallographic analysis of a murine CD8 ectodomain fragment in complex with H2Kb. Immunity 1998; 9:519-530.
30.
Wang JH, Smolyar A, Tan K, Liu JH, Kim M, Sun ZJ, Wagner G, Reinherz EL.
Structure of a heterophilic adhesion complex between human CD2 and CD58 (LFA-3)
counter-receptors. Cell 1999; 97:791-803.
31.
Green N, Rosebrook J, Cochran N, Tan K, Wang J-H, Springer TA, Briskin MJ.
Structural analysis of MAdCAM-1/a4b7 interactions reveals significant binding
determinants in both the first and second immunoglobulin domains. Cell Adhesion and
Communication, 1999; 7:167-181.
32.
Reinherz EL, Tan K, Tang L, Kern P, Liu J-H, Xiong Y, Hussey RE, Smolyar A, Hare B,
Zhang R, Joachimiak A, Chang H-C, Wagner G, Wang J-H. The structure of a T cell
receptor in complex with peptide and MHC class II. Science 1999; 286:1913-1921.
33.
Sasada T, Ghendler Y, Wang J-H, Reinherz EL. Thymic selection is influenced by
subtle structural variation involving the p4 residue of an MHC class I-bound peptide. Eur
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34.
Taraszka KS, Higgins JMG, Tan K, mandelbrot DA, Wang J-H, Brenner MB. Molecular
basis for leukocyte integrin E7 adhesion to epithelial (E-) cadherin. J Exp Med. 2000;
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35.
Higgins JMG, Cernadas M, Tan K, Irie A, Wang J-H, Takada Y, Brenner MB. The role of
 and  chains in integrin recognition by 7 integrins. J Biol Chem. 2000; 275: 2565225664.
36.
Wang J-H, Meijers R, Xiong Y, Liu J-H, Sakihama T, Zhang R, Joachimiak A, Reinherz
EL. Crystal structure of the human CD4 N-terminal two domain fragment complexed to
a class II MHC molecule. Proc Natl Acad Sci USA 2001; 98:10799-10804.
37.
Kim MK, Sun Z-Y J, Byron O, Campbell G, Wagner G, Wang J-H, Reinherz EL.
Molecular dissection of the CD2-CD58 counterreceptor interface identifies CD2 Tyr86
and CD58 Lys34 residues as the functional 'hot spot'. J Mol Biol. 2001; 312:711-20.
38.
Sasada T, Touma M, Chang H-S, Clayton LK, Wang J-H, Reinherz EL. Involvement of
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39.
Jing H, Takagi J, Liu J-H, Lindgren S, Zhang R, Joachimiak A, Wang J-H, Springer TA.
Archaeal surface layer proteins contain  propeller, PKD and  helix domains and are
related to metazoan cell surface proteins. Structure 2002; 10:1453-1464.
40.
Tan K., Zelus BD, Meijers R, Liu J-H, Bergelson JM, Duke N, Zhang R, Joachimiak A,
Holmes KV, Wang J-H. Crystal structure of murine sCEACAM1a[1,4]: a coronavirus
receptor in the CEA family. EMBO J. 2002; 21:2076-2086.
41.
Tan K, Duquette M, Liu J-H, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang J-H.
Crystal structure of the TSP-1 type 1 repeats: A novel layered fold and its biological
implication. J Cell Biol. 2002; 159:373-382.
42.
Sasada T, Yang Y, Lai C-C, Clayton LK, Liu J-H, Parisini E, Wang J-H, Reinherz EL.
Disparate peptide-dependent thymic selection outcomes in 2M versus TAP-1 deficient
mice: Implications for repertoire formation. Eur J Immunol. 2003; 33:368-380.
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Liu Y, Xiong Y, Naidenko OV, Liu J-H, Zhang R, Joachimiak A, Kronenberg M,
Cheroutre H, Reinherz EL, Wang J-H. The crystal structure of a TL/CD8 complex at
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44.
Shimaoka M, Xiao T, Liu J-H, Yang Y, Dong Y, Jun C-D, McCormack A, Zhang R,
Joachimiak A, Takagi J, Wang J-H, Springer TA. Structures of the aL I domain and its
complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell 2003;
112: 99-111.
45.
Takagi J, Yang Y, Liu J-H, Wang J-H, Springer TA., Complex between nidogen and
laminin fragments reveals a paradigmatic -propeller interface. Nature 2003; 424: 969974.
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Yang Y, Jun C-D, Liu J-H, Zhang R, Jochimiak, A, Springer TA, Wang J-H. Structural
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integrins and binding of ligand-mimetic therapeutics to the platelet receptor for
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Qiao Z, Kim M, Reinhold B, Montefiori D, Wang J-H, Reinherz EL. Design, expression
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Song G, Yang Y, Liu J-H, Casasnovas JM, Shimaoka M, Springer TA, Wang J-H.
Atomic resolution view of ICAM recognition revealed in a 1.65Å structure of a complex
between the binding domains of ICAM-3 and integrin L 2. Proc Natl Acad Sci USA.
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Attinger A, Devine L, Wang-Zhu, Y, Martin, D, Wang J. H, Reinherz EL, Kronenberg M,
Cheroutre H, Kavathas P. Molecular basis for the high affinity interaction between the
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Meijers R, Lai C-C, Yang Y, Liu J-H, Zhong W, Wang J-H, Reinherz EL. Crystal
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Chang HC, Tan K, Ouyang J, Parisini E, Liu J-H, Le L, Wang X, Reinherz EL, Wang JH. Structural and mutational analyses of a CD8 heterodimer and comparison with
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Tan K, Duquette M, Liu J-H, Zhang R, Joachimiak A, Wang J-H, Lawler J. The
Structures of the Thrombospondin-1 N-terminal domain (TSPN-1) and its complex with a
synthetic Pentameric Heparin. Structure, 2006; 14: 33-42
54.
Meijers R, Puettmann-Holgado R, Skiniotis G, Liu J-H, Walz T, Wang J-H, Schmucker
D., Structural Basis of Dscam Isoform specificity, Nature, 2007; 449: 487-491
55.
Parisini E, Higgins JMG, Liu J-H, Brenner MB, Wang J-H. The crystal structure of
human E-cadherin domains 1 and 2, and comparison with other cadherins in the context
of adhesion mechanism, J. Mol. Biol., 2007; 373: 401-411
56.
Tan K, Duquette M, Liu J-H, Shanmugasundaran K, Joachimiak A, Gallagher JT, Rigby
AC, Wang J-H and Lawler J. Heparin-induced cis- and trans-dimerization modes of the
thrombospondin-1 N-terminal domain. J. Biol. Chem. 2008, 283: 3932-3941
57.
Sun ZYJ, Oh KL, Kim M, Yu J, Brusic V, Song L, Qiao Z, Wang J-H, Wagner G,
Reinherz EL. HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41
ectodomain region on the viral membrane. Immunity, 2008, 28: 52-63
58.
Grotenbreg GM, Roan NR, Guillen E, Meijers R, Wang J-H, Bell GW, Starnbach MN,
Ploegh HL. Discovery of CD8+ T-cell epitopes in Chlamydia trachomatis infection
through use of caged class I MHC tetramers. Proc Natl Acad Sci USA. 2008; 105: 383135
59.
Ng A., Zhang H., Tan K., Li Z., Liu J-H., Chan P., Li S-M., Chan W-Y., Au S.,
Joachimiak A., Walz T., Wang J-H., Shaw P-C. Structure of the influenza H5N1
nucleoprotein: implications for RNA binding, oligomerization and vaccine design. FASEB
J., 2008, 22: 3638-3647
60.
Tan K., Duquette M., Liu J-H., Joachimiak A., Lawler J., Wang J-H., The Crystal
Structure of the Heparin-binding Reelin-N Domain of F-spondin. J. Mol. Biol., 2008; 381:
1213-1223
61.
Zhang H., Casasnovas JM., Jin M., Liu J-H., Gamberg CG., Springer TA., Wang J-H.,
An unusual allosteric mobility of the C-terminal helix of a high affinity L integrin I domain
variant bound to ICAM-5. Mol. Cell, 2008; 31: 432-437
Reviews:
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5.
Stuart D, Liang DC, Dai JB, Todd R, Lou MZ, You JM, Li JY, Wang JH. The solution of
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Wang JH. How to design and modify protein molecules. In Progress in Biochem. and
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8.
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and interaction of CD4. Cold Spring Harbor Symp. on Quant. Biol. #57, CSH Laboratory
Press, 1992; 541-548.
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Harrison SC, Wang JH, Yan YW, Garrett T, Liu JH, Moebius U, Reinherz EL. Structure
and interactions of CD4. Proc. of Novo Nordisk Foundation Symp. No. 6 Leukocyte
Adhesion, Basic and Clinical Aspects (Gahmberg CG, Mandrup-Poulsen T, Wogensen
Bach L, Hokfelt B, eds), Holland: Elsevier, 1992; 449-473.
11.
Wang J-H, Springer TA. Structural specializations of immunoglobulin superfamily
members for adhesion to integrins and viruses. Immunol Rev. 1998; 163: 197-215.
12.
Wang JH, The insulin connection: Dorothy Hodgkin and the Beijing Insulin Group.
Trends in Biochem. Sci. 1998; 23: 497-500
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Wang J-H, Reinherz EL. Structural basis of cell-cell interactions in the immune system.
Curr Op Struct Biol. 2000; 10:656-661.
14.
Wang J-H, Reinherz EL. Structural basis of T cell recognition of peptides bound to
MHC molecules. Mol Immunol. 2001; 38:1039-1049.
Progress in Bicohem. and Biophys
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Wang J-H. Protein recognition by cell surface receptors: physiological receptors versus
virus interactions. Trends in Biochemical Sciences. 2002; 27:122-126.
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Wang, J-H, Eck, MJ. Assembling atomic resolution views of the immunological
synapse. Current Opinion in Immunol. 2003; 15: 286-293.
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and conformational regulation of cell adhesion. Advances in Prot. Chem. 2004; Volume
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Wang J-H., Molecular mechanism of cell-cell recognition. Progress in Biochem.. and
Biophys., 2004; 31: 385-392.
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Wang J-H, Mallis R.J. and Reinherz, E.L., Immunodominant-peptide recognition: Beta
testing TCR. Immunity, 2008; 28: 139-141
Research projects during the last three years:
NIH HL 48675, Integrins and modular surface proteins in vasculature, program leader: Timothy
Springer, Proj. 2: Structure and interaction of IgSF and integrin families, P.I. Jia-huai Wang
Project period: 9/20/00-8/31/05; 9/1/05-8/31/10
Specific aims: The goal of this project is to study the structures of IgSF proteins on
endothelium, carry out structural dissection of a leukocyte integrin molecule and study
the interaction of these IgSF proteins and integrins
Claudia Adams Barr Program Award: Structure and interactions of nucleoprotein (NP) of
influenza virus H5N1 (PI: Jia-huai Wang).
Project period: 7/1/07-6/30/09
Specific aims: The long-term goal of this project is to carry out systematic structural analyses of
interactions of H5N1 NP with various viral molecules as well as proteins from the host
cell. The ultimate aim is to formulate therapeutic and preventive strategies to interfere
with these interactions.
NIH AI43649, HIVRAD: Structural approaches to vaccine development; PI: E. Reinherz,
Investigator: Proj. 1: Structure-based design for Nabs against SIV/HIV
Project period: 9/30/02-7/31/07
Specific aims: Development of mini-protein variants of SIV and HIV envelope proteins for
vaccine design aimed at generating broadly neutralizing antibody responses
Completed:
NIH 2RO1 AI25231, Molecular genetics of the receptor for MVH; P.I.: K. Holmes, Wang,
subcontract leader,
Project period: 7/1/03-12/31/07
Specific aims of project: To understand at the molecular level what determines the species
specificity of coronavirus
NIH HL 49081, Structure and function of thrombospondin-4, PI: J.W. Lawler, Wang,
subcontract leader,
Project period: 4/15/04-3/31/08
Specific aims: To determine the structure and function of two members of the subgroup B
thrombospondins, cartilage oligomeric matrix protein and thrombospondin-4.
NIH GM56008, MHCI-restricted TCR recognition: Structural basis, P.I. Jia-huai Wang
Project period: 1/1/98-12/31/04 (included one year no cost extension)
Specific aims: X-ray crystal structural determination of ligated and unligated (with VSV8/Kb
complex) N15 TCR and other TCRs to unravel molecular mechanisms of TCR
recognition for the MHC class I-restricted system.
NIH HL 68003, Structure and function of thrombospondin-1, (PI: J.W. Lawler) Wang,
subcontract leader, Project period: 4/1/02-3/31/06
Specific aims: Crystal structure determination of type 1 repeat and its complex with ligand CD36
NIH 1U19 AI57330, CCTR program project.: Protective orthopox immunization in normals and
patients with cancer or eczema (program leader E.L. Reinherz). PI for Pilot project 2
Project period: 9/30/03-8/31/08 (1.5 year for pilot project)
Specific aims: Analysis of human immunity to orthopox viruses
NIH 1RO1 AI50900, Thymic vaccination: Manipulating the T cell repertoire, PI: E. Reinherz
Project period: 3/19/01-2/28/05 (includes one year no cost extension)
Specific aims: Approaches to development of vaccines against mouse infectious pathogens
(LCMV, VSV, influenza A)
NIAID 1PO1 AI/MH43649, Novel HIV therapies - IPCP program project (program leader E.L.
Reinherz), Proj. 2: Structural biology of HIV envelope interactions, P.I.: S. Harrison
Project period: 8/1/98-7/31/02
Specific aims: Crystallography, site-directed mutagenesis and functional studies of CD4 and
CD4-gp120 interaction