Klyosov_CV_2013_Full - World Academy of Art and Science

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RESUME
ANATOLE ALEX KLYOSOV
Founder and Chief Scientist, Emeritus
Member, the Scientific Board
Galectin Therapeutics, a Public Company
4960 Peachtree Industrial Boulevard, Suite 240
Norcross, GA 30071
The United States of America
Phone (617) 610-6803
Fax (617) 964-4983
[email protected]
Home address:
36 Walsh Road
Newton, MA 02459
Degrees:
1983
1978
1977
1972
1969
Professor of Biochemistry, the Russian Academy of Sciences
Professor of Chemistry, Moscow University, Moscow, Russia
D.Sc., Physical Chemistry, Moscow University, Moscow, Russia
Ph.D., Department of Chemistry, Moscow University, Moscow, Russia
M.S., Chemical and Biological Kinetics, Moscow University, Moscow, Russia
Distinctions:
Laureate, the Young Scientist National (USSR) Research Award, 1978
Laureate, the USSR National Prize in Science and Technology,1984
Fellow, World Academy of Art and Science, Elected in 1989
Career:
2013
Emeritus Founder and Chief Scientist, Galectin Therapeutics
2006-2013 Chief Scientist, Galectin Therapeutics, Inc. (public company) Newton, MA, then
Norcross, GA
1996-2006 Vice President, Research & Development, Kadant Composites (public company),
Bedford, MA
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1987-1998 Professor of Biochemistry, Center for Biochemical and Biophysical Sciences and
Medicine, Harvard Medical School, Boston, Massachusetts
1981-1990 Professor and Head, Biochemistry Research Laboratory, USSR Academy of
Sciences
1978-1981 Professor of Chemistry, Department of Chemistry, Moscow University
1974-1975 Visiting Lecturer on Biological Chemistry and Molecular Biology, Harvard
University
1969-1978 Scientist (Division of Biokinetics), Senior Scientist, and Assistant Professor,
Moscow State University, Department of Chemistry
PRINCIPAL CONTRIBUTIONS TO SCIENCE
-- Development of a general theory of kinetics and specificity of enzyme catalysis. More than a
hundred of academic articles and several books were published in the area, including “Enzyme
Catalysis” (in two volumes, in 1980 and 1984) and textbook “The Practical Course of Chemical and
Enzyme Kinetics” (1976). Laureate, the USSR State Prize in Science in 1984 for those studies.
-- Development of science of the enzymatic conversion of cellulose to glucose. More than a hundred
of academic articles and several books were published in the area, including a two-volume study for
the United Nations (1984 and 1989), books “Enzyme Engineering” (1987), “Biotechnology of the
Enzymatic Conversion of Cellulose” (1988), “Enzyme Engineering at the Industrial Level” (1989),
edited books “Enzyme Engineering - Future Directions” (1980), “Bioconversion of Plant Materials”
(1986, ed. G.K.Skryabin, E.L.Golovlev, A.A.Klyosov), “Microbiology and Biochemistry of
Degradation of Plant Materials” (1988, ed. G.K.Skryabin, E.L.Golovlev, A.A.Klyosov)
-- Development of science and engineering of new composite materials, which has resulted in
publication of the book “Wood-Plastic Composites” (John Wiley and Sons, 2007, 700 pages), which
was translated to Russian (2010) and Chinese (2010).
-- Development of science of carbohydrate and plant polysaccharides in drug design, which has
resulted in many articles in Biochem. J., Glycobiology, Carbohydrate Research, publications of
books “Carbohydrate Drug Design” (Oxford University Press, 2006), “Galectins” (John Wiley and
Sons, 2008), “Glycobiology Drug Design” (Oxford University Press, 2012, in the press) and
“Galectins and Disease – Implications for Targeted Therapeutics” (Oxford University Press, 2012, in
the press).
-- Development of science of DNA genealogy, which is essentially kinetics of mutations in the DNA
with implications in history studies. More than a hundred articles were published in the area,
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including those in Human Genetics, J. Genetic Genealogy, Advances in Anthropology. A book “The
Origin of Man” was published in Russian language (2010, 1024 pages).
SUMMARY OF QUALIFICATIONS, in more detail
Ph.D., D.Sc., professional expertise in enzymology, biochemistry, biotechnology, biomedical
sciences, chemical engineering, DNA-related human history.
For many years taught enzyme kinetics and mechanisms at Moscow State University,
Moscow, Russia. Author of "Practical Course of Chemical and Enzyme Kinetics" (1976) that still is
a major textbook on enzyme kinetics in the former USSR. Author of textbooks "Enzyme Catalysis"
(2 volumes), "Enzyme Engineering", "Enzyme Engineering at the Industrial Level", and others, in the
U.S. – books “Industrial Enzyme Engineering” (a 6-volume treatise, Harvard Medical School, 1996),
“Enzyme Engineering – Future Directions” (Plenum Press, 1980), “Carbohydrate Drug Design”
(Oxford University Press, 2006), “Galectins” (John Wiley & Sons, 2008), and “Wood-Plastic
Composites” (John Wiley & Sons, 2007), the latter was translated and published in China and
Russia. In 1974-75 taught Enzyme Kinetics at Harvard Medical School, M.D.-Ph.D. Program.
Experience in chemistry of natural compounds, including extraction (plant materials),
isolation, purification and characterization, and medicinal chemistry. Experience in carbohydrate
chemistry and biochemistry, particularly on polysaccharides, including cellulose, galactomannans,
hemicellulosics. Experience in enzymatic conversion of cellulosic materials to small sugars (glucose
and its oligomers). Experience in galectins, which are galactose-specific lectins, controlling many
inflammatory pathologies, including various types of cancer, fibrosis, cardiovascular diseases,
asthma, etc.
An extensive experience in science strategy and evaluation: was a research group leader,
Professor and Head, Carbohydrate Research Laboratory, the USSR Academy of Sciences, Moscow
(up to 30 staff members and postdoctoral fellows). A consultant in industry (applied enzymology,
biotechnology), head of research programs at the former USSR Academy of Sciences; a scientific
supervisor of more than 60 postgraduate students. A reviewer in many international funds and
committees on evaluation of research. Vice-President of a chemical engineering and manufacturing
company (1996-2005), chief scientist of a biomedical public company (2000 -present).
From 1990 to 1996 have been doing an experimental work at the Center for Biochemical and
Biophysical Sciences and Medicine, Harvard Medical School (head - Dr. Bert L. Vallee). General
area – cancer research (angiogenesis), biochemistry of alcohol abuse; more specifically alcohol/aldehyde enzymatic conversion and specific inhibition of the enzymes of acetaldehyde
metabolism, and identification of compounds of plant origin that specifically reduce appetite to
alcohol (anti-dipsotropic activity), among them carbohydrate conjugates/isoflavons, galactans and
mixed glucosides and galactomannans.
From 1996 through 2005 – Vice President, Research and Development, Kadant Composites
Inc. a publicly held company in Bedford, Massachusetts, then LDI Composites, a private company,
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which acquired Kadant Composites in October, 2005. Established, equipped and ran a laboratory,
performing work in biochemistry, microbiology, chemical analysis, as well as extrusion of polymer
composites, strain and stress studies, and numerous ASTM testing of polymer composite materials.
From 2000 - Pro-Pharmaceuticals, Inc., Founder, consulting Chief Scientist and member of
the Scientific Advisory Board, since January 2006 – Chief Scientist. Co-inventor of an anticancer
drug delivery system, DAVANAT®, which completed Clinical Trials, Phase I and Phase II.
HONORS
The USSR National Committee on Science and Technology Award in 1976
Moscow State University Young Scientist Research Award in 1977
Laureate, the Young Scientist National (USSR) Research Award in 1978
Gold Medal, the USSR National Exhibition on Scientific and Technical Achievements in 1983
Laureate, the USSR National Prize in Science and Technology in 1984
Member, World Academy of Art and Science, Elected in 1989
Who’Who publications:
"Who's Who in America", 55th Edition, 2001, p. 2882 (and subsequent editions), Volume 1.
"Who's Who in Science and Engineering", 6th Edition, 2002-2003, p. 506 (and subsequent
editions)
"Who's Who in the World", 19th Edition, 2002, p. 1136 (and subsequent editions).
MEMBERSHIP, SCIENTIFIC COUNCILS AND SOCIETIES
1972-1990
1975-Present
1977-1987
1981-1989
1984-1989
1985-Present
1989-Present
1991-1992
1991-Present
2000-2007
USSR Biochemical Society
American Chemical Society
Vice-Chairman, Council on Non-Conventional Renewable Resources for
the Food Industry, the USSR Academy of Sciences
Main Board, Council on Biotechnology at the USSR Academy of Sciences
Main Board, Moscow Division, USSR Biochemical Society
International Organization on Biotechnology and Bioengineering
World Academy of Art and Science (WAAS)
The New York Academy of Sciences
Biofocus Foundation, WAAS; Expert Panel
American Society of Plastic Engineers
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EDITORIAL BOARDS
1981-1991
1986-1990
1991-Present
2008-Present
2011-Present
Applied Biochemistry and Microbiology (USSR)
Biotechnology (USSR), Editor-in-Chief
Acta Biotechnologica/Engineering in Life Sciences (Germany)
Proceedings, the Academy of DNA Genealogy (Boston – Moscow –
Tsukuba), Editor-in-Chief
Advances in Anthropology (USA, International), since 2013 - Editor-in-Chief
http://www.scirp.org/journal/aa/
Consulting Experience:
Consulting Chief Scientist, member of Scientific Advisory Board, Pro-Pharmaceuticals, Inc.
(AMEX: PRW) (2000 – 2005)
UNIDO (United Nations Industrial Development Organization), author of two UNIDO
studies (1984 and 1989).
The World Bank (Washington, D.C.) - 1990
Tigney Technology, Inc. (Edmonton, Alberta, Canada) - 1990-1996
Mayfield Fund (California) - 1991-1992
InterSpex Products, Inc. (San-Francisco, CA) - 1993-1996
American Environmental Laboratories, Inc. (Ohio) - 1994-1995
SafeScience, Inc. - 1996-2000
Zepter International - 1999
A number of WPC manufacturing companies in the US, China, Russia.
Expert Scientist in law firms, in a number of litigations.
Publications:
More than 500 papers in refereed journals and editions, including 20 books, 64 patents and patent
applications. Many lectures at international conferences and symposia on wood-plastic composites,
including those in Vienna (2002), Bordeaux (2003), New Orleans (2003, 2004), Baltimore (2005),
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Madison (2003, 2005, 2009), Toronto (2004, 2006, 2012), San Antonio (2006), Xian, China (2007),
Shenyang, China (2008), Shenzhen, China (2009), Tsingtao, China (2010), Huangshi City, China
(2011), Keln, Germany (2011), Moscow, Russia (2009) and many others.
BIBLIOGRAPHY:
BOOKS
1. Berezin, I.V., Klyosov, A.A. Enzymes as Chemical Catalysts. ZNANIE, Moscow, 1971,
62 p.
2. Berezin, I.V., Klyosov, A.A. The Practical Course of Chemical and Enzyme Kinetics.
MOSCOW UNIVERSITY PRESS, Moscow, 1976, 326 p.
http://www.y10k.ru/books/detail6844.html
3. Klyosov, A.A., Berezin, I.V. Enzymatic Catalysis.Vol.1. Specificity of Enzyme Catalysis.
MOSCOW UNIVERSITY PRESS, Moscow, 1980, 264 p.
4. Klyosov, A.A. Enzymatic Catalysis. Vol.2. Enzymatic Degradation of Polymers. MOSCOW
UNIVERSITY PRESS, Moscow, 1984, 214 p.
5. Berezin, I.V., Klyosov, A.A., et al. Enzyme Engineering. VYSHAYA SHKOLA, Moscow,
1987, 143 p.
6. Sinitsyn, A.P., Klyosov, A.A., Rabinovich, M.L., Gusakov, A.V., Morozov, A.M.
Biotechnology of the Enzymatic Conversion of Cellulose. VINITI PRESS, Moscow, 1988,
153 p.
7. Klyosov, A.A. Enzyme Engineering at the Industrial Level. VINITI PRESS, Moscow, 1989,
184 p.
8. Enzyme Engineering - Future Directions (ed. L.B.Wingard, I.V. Berezin, A.A. Klyosov),
PLENUM PRESS, New York, 1980, 521 p.
http://books.google.com/books/about/Enzyme_engineering.html?id=5ctTAAAAMAAJ
9. Bioconversion of Plant Materials (ed. G.K.Skryabin, E.L.Golovlev, A.A.Klyosov),
NAUKA, Moscow, 1986, 296 p.
10. Microbiology and Biochemistry of Degradation of Plant Materials (ed. G.K.Skryabin,
E.L.Golovlev, A.A.Klyosov), NAUKA, Moscow, 1988, 320 p.
11. Lectins in Studying Proteins and Carbohydrates (ed. A.A.Klyosov), VINITI PRESS,
Moscow, 1987, 288 p.
12. Industrial Enzyme Engineering, Harvard Medical School, Boston, 1996, 6-volumes.
13. Carbohydrate Drug Design (ed. Anatole Klyosov, Zbigniew Witczak, David Platt), Oxford
University Press 2006, 323 p. http://www.amazon.com/Carbohydrate-Drug-Design-AcsSymposium/dp/0841239460/ref=sr_1_5?s=books&ie=UTF8&qid=1372285521&sr=15&keywords=Klyosov
14. Klyosov, A.A. Wood-Plastic Composites, John Wiley & Sons, 2007, 698 p.(translated to
Chinese [2010] and Russian. http://www.amazon.com/Wood-Plastic-Composites-AnatoleKlyosov/dp/0470148918/ref=sr_1_1?s=books&ie=UTF8&qid=1372285335&sr=11&keywords=Klyosov
15. Galectins (ed. Anatole Klyosov, Zbigniew Witczak, David Platt), John Wiley & Sons,
2008, 279 p. http://www.amazon.com/Galectins-AnatoleKlyosov/dp/0470373180/ref=sr_1_2?s=books&ie=UTF8&qid=1372285416&sr=16
2&keywords=Klyosov
16. Klyosov, A.A. The Internet: Notes of a Scientist. Moscow University Press, 2010, 512 p.
http://www.chem.msu.su/rus/books/2010/klesov/welcome.html
17. Glycobiology and Drug Design (ed. Anatole Klyosov), Oxford University Press, 2013,
331 pp. http://www.amazon.com/Glycobiology-Drug-Design-AcsSymposium/dp/0841227659/ref=sr_1_3?s=books&ie=UTF8&qid=1372285521&sr=13&keywords=Klyosov
18. Galectins and Disease. Implications for Targeted Therapeutics (ed. Anatole Klyosov and
Peter Traber), Oxford University Press, 2013, 456 pp. http://www.amazon.com/GalectinsImplications-Targeted-TherapeuticsSymposium/dp/0841228809/ref=sr_1_4?s=books&ie=UTF8&qid=1372285521&sr=14&keywords=Klyosov
19. Klyosov, A.A., Tynyaev, A.A. The Origin of Man. Belye Alvy, Moscow, 2010, 1024 pp.
http://www.vshtate.ru/good381208-Izdatelstvo-Belye-alvy-Klesov-AA-Tyunyaev-AAProishozhdenie-cheloveka-po-dannym-arheologii-antropologii-i-DNK-genealogii.html
20. Klyosov, A.A. Origin of Slavs. Moscow, “Algorithm”, 2013, 511 pp.
http://www.moscowbooks.ru/book.asp?id=677941
21. Klyosov, A.A. Origin of Slavs and other peoples. Belgrade (in Serbian), 2013, in the press.
22. Klyosov, A.A. Entertaining DNA Genealogy. Moscow, 2013, in the press.
REVIEW PAPERS
In English:
23. Berezin, I.V., Klyosov, A.A., Martinek, K. General Principles of Enzymatic Catalysis. In:
"Chemistry Reviews (Soviet Scientific Reviews)", 1979, Section B, vol.1, 205-277.
24. Klyosov, A.A., Rabinovich, M.L. Enzymatic Conversion of Cellulose to Glucose: Present
State of the Art and Potential. In:"Enzyme Engineering: Future Directions", PLENUM
PRESS, New York, 1980, p. 83-165.
25. Klyosov, A.A. Enzymatic Conversion of Cellulosic Materials to Sugar and Alcohol: the
Technology and its Implications. UNIDO Study, Separate edition, 1984, 63 p.
26. Klyosov, A.A. Microbiology of Food and Feed. In:"Biotechnology and Bioprocess
Engineering". UNITED INDIA PRESS, New Delhi, 1985, p. 537-545.
27. Klyosov, A.A. Enzymatic Conversion of Cellulosic Materials to Sugar and Alcohol. The
Technology and its Implications. APPL. BIOCHEM. BIOTECHNOL., 12, 249-300,
1986.
28. Klyosov, A.A. Enzyme Engineering at the Industrial Level. UNIDO Study, Separate
Edition, 1989, 108 p.
29. Klyosov, A.A. Cellulases of the Third Generation. In: "Bioprocess Engineering. The First
Generation". Ellis Horwood Limited, Chichester, England, 1989, p. 59-67.
30. Klyosov, A.A. Trends in Biochemistry and Enzymology of Cellulose Degradation.
BIOCHEMISTRY, 29, 10577-10585, 1990.
31. Klyosov, A.A. Carbohydrates and Drug Design. In “Carbohydrates Drug Design”, 2006, p. 2
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- 24.
32. Platt, D., Klyosov, A.A., Zomer E. Development of a Polysaccharide as a Vehicle to Improve
the Efficacy of Chemotherapeutics. In “Carbohydrates Drug Design”, 2006, p. 49 - 66.
33. Klyosov, A.A., Zomer, E., Platt, D. DAVANAT® and Colon Cancer: Preclinical and Clinical
(Phase I) Studies. In “Carbohydrates Drug Design”, 2006, p. 67 - 104.
34. Klyosov, A.A., Anna N. Tevyashova, Eugenia N. Olsufyeva, Maria N. Preobrazhenskaya,
Eliezer Zomer and David Platt. Synthesis and Biological Activity of Doxo-Galactose and
Doxo-Galactomannan, New Conjugates of Doxorubicin with D-galactose and 1,4--Dgalactomannan. In “Carbohydrates Drug Design”, 2006, p. 105 - 130.
35. Klyosov, A.A. Galectins and their Functions in Plain Language. In “Galectins”, 2008, pp. 931.
36. Klyosov, A.A. Carbohydrates and Drug Design. In “Glycobiology and Drug Design” (A.A.
Klyosov, ed.), 2013, Oxford University Press, pp. 3-22.
37. Klyosov, A.A. Galectin-Targeted Drug Design. In “Glycobiology and Drug Design” (ed. by
Anatole A. Klyosov), Oxford University Press, 2013, pp. 25-66.
38. Zomer, E., Klyosov, A.A., Platt, D. Development of a Galactomannan Polysaccharide as a
Vehicle to Improve the Efficacy of Chemotherapeutics. In “Glycobiology and Drug Design”
(ed. by Anatole A. Klyosov), Oxford University Press, 2013, pp. 69-87.
39. Klyosov, A.A., Zomer, E., Platt, D. DAVANAT® (GM-CT-01) and Colon Cancer: Preclinical
and Clinical (Phase I and II) Studies. In “Glycobiology and Drug Design” (ed. by Anatole A.
Klyosov), Oxford University Press, 2013, pp. 89-130.
40. Tevyashova, A.N., Klyosov, A.A., Olsufyeva, E.N., Preobrazhenskaya, M.N., Zomer, E.
Synthesis and Biological Activity of Galactomycin and Doxo-Davanat, New Conjugates of
Doxorubicin with D-galactose and 1,4--D-galactomannan. In “Glycobiology and Drug
Design” (ed. by Anatole A. Klyosov), Oxford University Press, 2013, pp. 131-154.
41. Klyosov, A.A., Traber, P.G. Galectins in Disease and Potential Therapeutic Approaches. In
“Galectins and Disease. Implications for Targeted Therapeutics (ed. by Anatole A. Klyosov
and Peter G. Traber), Oxford University Press, 2013.
US PATENTS and applications
42. 6,642,205 (November 4, 2003). Klyosov, A.A., Platt, D. Method and Compositions for
Reducing Side Effects in Chemotherapeutic Treatments.
43. 6,645,946 (November 11, 2003). Klyosov, A.A., Platt, D. Delivery of a Therapeutic
Agent in a Formulation for Reduced Toxicity.
44. 6,914,055 (July 5, 2005). Klyosov, A.A., Platt, D. Delivery of a Therapeutic Agent in a
Formulation for Reduced Toxicity.
45. 6,982,255 (January 3, 2006). Klyosov, A.A., Platt, D. Delivery of a Therapeutic Agent in
a Formulation for Reduced Toxicity.
46. 7,012,068 (March 14, 2006). Klyosov, A.A., Platt, D. Co-administration of a
Polysaccharide with a Chemotherapeutic Agent for the Treatment of Cancer.
47. Platt, D., Klyosov, A. Selectively Depolymerized Galactomannan Polysaccharide. US
Patent No. 7,893,252, February 22, 2011.
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48. Platt, D.,, Klyosov, A. Co-administration of Polysaccharide with a Chemotherapeutic
Agent for the Treatment of Cancer. Patent of Australia 272022B2, February 17, 2011.
Terms of the Patent: 20 years from 7 September 2004.
49. Klyosov, A., Platt, D. Co-administration of Polysaccharide with a Chemotherapeutic
Agent for the Treatment of Cancer. Patent of Japan, No. 4744782, May 20, 2011.
50. Klyosov, A., Platt, D. Co-administration of a Polysaccharide with a Chemotherapeutic
Agent for the Treatment of Cancer. Patent of EP, No. 1383516.
51. Klyosov, A., Platt, D. Co-administration of a Polysaccharide with a Chemotherapeutic
Agent for the Treatment of Cancer. Patent of BE, No. 1383516.
52. Klyosov, A., Platt, D. Co-administration of a Polysaccharide with a Chemotherapeutic
Agent for the Treatment of Cancer. Patent of CH, No. 1383516.
53. Klyosov, A., Platt, D. Co-administration of a Polysaccharide with a Chemotherapeutic
Agent for the Treatment of Cancer. Patent of DE, No. 1383516.
54. Klyosov, A., Platt, D. Co-administration of a Polysaccharide with a Chemotherapeutic
Agent for the Treatment of Cancer. Patent of DK, No. 1383516.
55. Klyosov, A., Platt, D. Co-administration of a Polysaccharide with a Chemotherapeutic
Agent for the Treatment of Cancer. Patent of ES, No. 1383516.
56. Klyosov, A., Platt, D. Co-administration of a Polysaccharide with a Chemotherapeutic
Agent for the Treatment of Cancer. Patent of FR, No. 1383516.
57. Klyosov, A., Platt, D. Co-administration of a Polysaccharide with a Chemotherapeutic
Agent for the Treatment of Cancer. Patent of GB, No. 1383516.
58. Klyosov, A., Platt, D. Co-administration of a Polysaccharide with a Chemotherapeutic
Agent for the Treatment of Cancer. Patent of IE, No. 1383516.
59. Klyosov, A., Platt, D. Co-administration of a Polysaccharide with a Chemotherapeutic
Agent for the Treatment of Cancer. Patent of LU, No. 1383516.
60. Klyosov, A., Platt, D. Co-administration of a Polysaccharide with a Chemotherapeutic
Agent for the Treatment of Cancer. Patent of NL, No. 1383516.
US PATENT APPLICATIONS
61. Klyosov, A. Methods for reducing the incidence of chemotherapy-induced mucositis.
PCT/US2009/053115, filed August 7, 2009.
62. Klyosov, A. Compounds, formulations and methods for reducing mucositis and/or other
galectin-dependent pathologies. Provisional 61/332,242, filed May 7, 2010.
63. Platt, D., Zomer, E., Klyosov, A. Galactose-Pronged Polysaccharides in a Formulation
for Antifibrotic Therapies. US Patent Application Publication, 20080107622, Published
May 8, 2008 (allowed).
64. Platt, D., Klyosov, A.A., Zomer, E. Co-Administration of a Polysaccharide with a
Chemotherapeutic Agent for the Treatment of Cancer. US Patent Application Publication,
20080207516, published August 28, 2008.
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65. Platt, D., Zomer, E., Compositions and Methods for the Enhancement of Chemotherapy
with Microbial Cytotoxins. U.S. Patent Application Publication 2008-286251, published
November 20, 2008
66. Platt, D., Klyosov, A.,A., Zomer, E. Compositions and methods for targeting metastatic
tumors using multivalent ligand-linked carbohydrate polymers. Published August 28,
2008.
67. Klyosov, A.A., Traber, P.G. Galectin Binding and Blocking Polysaccharides. Provisional
61/439,800, filed February 4, 2011.
68. Klyosov, A.A., Traber, P.G. Methods of Treatment of Ischemic Disease and/or Chronic
Cardiovascular Disease with Galectin Binding Agents.
69. Platt, D., Klyosov, A.A. Co-administration of a polysaccharide with a chemotherapeutic
agent for the treatment of cancer. 12/962,296, filed August 9, 2003.
70. Traber, P.G., Zomer E., Klyosov, A.A. Methods of Treatment for Non-Alcoholic
Steatohepatitis (NASH). Provisional U.S. Patent Application, filed September 16, 2011,
61/535,655.
71. Traber, P.G., Zomer E., Klyosov, A.A. Methods of Treatment for Non-Alcoholic
Steatohepatitis (NASH). Provisional U.S. Patent Application, filed June 6, 2012,
61/656/288.
72. Klyosov, A.A. The Optimal Structural Signature for α-Galactomannan binding to
Galectin-1. Provisional U.S. Patent Application, filed September 13, 2011, 61/534,024.
INTERNATIONAL PATENT APPLICATIONS
73. Klyosov, A.A., Platt, D. Co-administration of a polysaccharide with a chemotherapeutic
agent for the treatment of cancer. EPO 10184166.6
74. Klyosov, A.A., Platt, D. Co-administration of a polysaccharide with a chemotherapeutic
agent for the treatment of cancer. EP 04783211.8
75. Platt, D., Klyosov, A. Co-administration of polysaccharide with a chemotherapeutic agent
for the treatment of cancer. Australian Patent Application No. 2010257400. Austr. Ref.
19435PRO/BMN/tap, PRW ref. 89918.020603 (allowed)
76. Platt, D., Klyosov, A. Co-administration of a polysaccharide with a chemotherapeutic
agent for the treatment of cancer. Israel 174121, filed September 8, 2003.
77. Klyosov, A.A., Platt, D. Co-administration of a polysaccharide with a chemotherapeutic
agent for the treatment of a cancer. Japanese Patent Application No. 2002-574987, Y/R:
089919.02180; O/R: IP2003-149/KI (Our Ref. 089918.021804)
78. Platt, D., Zomer, E., Klyosov, A. Co-administration of a polysaccharide with a
chemotherapeutic agent for the treatment of cancer. Brazil PI0413410-0, filing September
8, 2003.
79. Platt, D., Zomer, E., Klyosov, A.A. Compositions and Methods for Treating Metastatic
Tumors Using Multivalent Ligand-Linked Carbohydrate Polymers. JP 2007-504160
80. European Patent Application No. 02731178.6, EPO Ref.: RJS\JWK\19462-5EP(PCT);
Our Ref. 89918.021803.
81. Methods for Reducing the Incidence of Chemotherapy-Induced Mucositis.
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PCT/US09/053115.
82. European Patent Application No. 10184166.6, EPO Ref.: RJS\JWK\19462-5EP-DIV; Our
Ref. 89918.021803.
83. 5,777,086 (July 7, 1998). Klyosov, A.A., Philippidis, G.P., Monovoukas, Y.A. Method of
Recovering Lignin from Pulp and Paper Sludge.
84. 5,876,505 (March 2, 1999). Klyosov, A.A., Philippidis, G.P., James, A.M., Monovoukas,
Y.A. Method of Producing Glucose from Papermaking Sludge Using Concentrated or
Dilute Acid Hydrolysis.
85. 5,919,424 (July 6, 1999). Klyosov, A.A., Philippidis, G.P., Monovoukas, Y.A. Method
of Recovering Minerals from Papermaking Sludge and Sludge-Derived Ash.
86. 5,961,941 (October 5, 1999). Klyosov, A.A., Philippidis, G.P., Monovoukas, Y.A.
Production of Precipitated Calcium Carbonate from Papermaking Sludge and SludgeDerived Ash.
87. 6,156,226 (December 5, 2000) Klyosov, A.A., Philippidis, G.P., James, A., Monovoukas,
Y.A. Liquid and Solid De-Icing Compositions and Methods for Making Same.
88. 6,758,996 (July 6, 2004) Monovoukas, Y.A., Anderson, S., Leeman, D., Klyosov, A.A.,
Philippidis, G.P. Cellulose-Reinforced Thermoplastic Composite and Methods of Making
Same.
RUSSIA Patents
89. Berezin, I.V., Kalunyanz, K.A., Rabinovich, M.L., Klyosov, A.A. et al. Preparation of
Sugars from Cellulose-Containing Plant Materials. SU 949002. Nov.27,1980/July 14, 1981.
90. Rabinovich, M.L., Klyosov, A.A., Berezin, I.V. Pretreatment of Polysaccharide Material
for a Subsequent Hydrolysis. SU 948145. Dec.26,1980/Aug.25,1981.
91. Berezin, I.V., Kalunyanz, K.A., Rabinovich, M.L., Klyosov, A.A. et al. Apparatus for the
Hydrolysis of Polysaccharide Materials. SU 962310, Nov.27,1980/June 1, 1982.
92. Rabinovich, M.L., Klyosov, A.A., Berezin, I.V., Myagkih, I.V., Martianov, V.A.
Purification of Cellulases. SU 975796, March 31,1981/July 21,1982.
93. Savizkene, R.Yu., Gerasimas, V.B., Rabinovich, M.L., Klyosov, A.A., Steponavichus, Yu.,
Denis, G.I. Determination of Endoglucanase Activity. SU 1112058, March 31, 1983/May
8,1984.
94. Danilyak, N.I., Klyosov, A.A., Karzov, V.F., Melnichuk, G.G., Yarovenko, V.L.
Maturation of the Konjak Alcohol. SU 1114054, Febr.17, 1982/May 15, 1984.
95. Devdariani, T.G., Dvali, C.Sh., Kvesitadze, G.I., Mudzhiri, L.A., Klyosov, A.A.
Immobilized Enzyme Preparation. 3419441/28-13, March 26, 1982/Sept.27, 1983.
96. Goldsteins, G.H., Rabinovich, M.L., Klyosov, A.A., Martyanov, V.A., Arens, A.K.
Adsorbent for Isolation of Cellulases and Xylanases. SU 1252337, Oct.30, 1984/Apr 22,
1986.
97. Goldsteins, G.H., Churilova, I.V., Rabinovich, M.L., Klyosov, A.A., Arens, A.K.
Isolation of Cellulolytic Enzymes. SU 1280875, Oct.30, 1984/Sept 1, 1986.
98. Klyosov, A.A., Nuzubidze, N.N., Lupova, L.M., Chramzova, V.I. Isolation of Alkaline
Proteases. SU 1350863, Nov.21, 1985/July 8, 1987.
11
99. Ivanova, G.S., Belezkaya, O.P., Golovlev, E.L., Zorina, A.I., Zubrizkaya, L.G., Klyosov,
A.A., Kulaev, I.S., Kulyako, N.I., Maryanovskaya, I.G., Okunev, O.N. Isolation of
Cellobiases. SU 1274297, July 30, 1984/Aug.1, 1986.
100.
Sinitsyn, A.P., Gusakov, A.V., Chernoglazov, V.M., Klyosov, A.A., Klyachko,
N.L., Khmelnizky, Yu.L., Martinek, K., Levashev, A.V., Berezin, I.V. Water-Soluble,
Immobilized Cellulase. SU 1300939, Sept.21, 1983/Dec.1, 1986.
101.
Efremov, A.B., Sinitsyn, A.P., Klyosov, A.A., Sizov, A.N., et al. Immobilized Yeast
Saccharomyces cerevisiae. SU 1381159, May 26, 1986/Nov.15, 1987.
102.
Sinitsyn, A.P., Rainina, E.I., Klyosov, A.A., Lozinsky, V.L., et al. Production of
Ethanol. 4080582/31-13, Apr.16, 1987.
103.
Klyosov, A.A., et al. SU 1243356.
104.
Kvarazhelia, M.S., Rabinovich, M.L., Dzhopua, Yu. Ch., Zikoridze, N.G., Dadiani,
R.G., Klyosov, A.A. Utilization of Wastes After Tea Production. 4329269/13, Sept.17,
1987/Sept 29, 1988.
105.
Kvarazhelia, M.S., Dzhopua, Yu.Ch., Morozova, E.S., Zikoridze, N.G., Rabinovich,
M.L., Klyosov, A.A. Production of Cellulases.
REVIEW PAPERS
In Russian:
106.
Berezin, I.V., Klyosov, A.A. Enzyme Electrodes. USPEKHI KHIMII, 45, 180-202,
1976.
107.
Berezin, I.V., Klyosov, A.A. Applications of Immobilized Enzymes in Analytical
Chemistry. Z. ANAL. KHIMIYI, 31, 797-819, 1976.
108.
Klyosov, A.A. Kinetic Methods of Enzymology. In:"Crystalline Enzymes", Vilnus,
1975, p. 117-125.
109.
Klyosov, A.A. Chemical Metalloenzymology. In:"Biological Aspects of Inorganic
Chemistry", NAUKOVA DUMKA, Kiev, 1977, p.65-86.
110.
Klyosov, A.A., Rabinovich, M.L. Enzymatic Hydrolysis of Cellulose. In:"Bioorganic
Catalysis and Enzyme Engineering", VINITI PRESS, Moscow, 1978, p.49-91.
111.
Svedas, V.K., Klyosov, A.A. Enzymatic Modification of Antibiotics: Study of
Penicillin Amidase from E. coli. Kinetics and Mechanism of Action. In:"Bioorganic
Catalysis and Enzyme Engineering", VINITI PRESS, Moscow, 1978, p.209-237.
112.
Klyosov, A.A. Kinetics of Enzyme Reaction. In:"Methods of Determination of
Enzyme Activities and Their Unification", No. 4, MOKSLAS, Vilnus, 1979, p.4-48.
113.
Klyosov, A.A. Specificity of Enzyme Catalysis. In:"Advances in Bioorganic
Catalysis", MOSCOW UNIVERSITY PRESS, Moscow, 1979, p.7-56.
114.
Klyosov, A.A. Industrial Processes Using Immobilized Enzymes. In:"Introduction to
Applied Enzymology", MOSCOW UNIVERSITY PRESS, Moscow, 1982, p.353-379.
115.
Klyosov, A.A. Enzymatic Conversion of Cellulose to Glucose. In: "Chemical
Enzymology", MOSCOW UNIVERSITY PRESS, Moscow, 1982, p.189-250.
116.
Klyosov, A.A. Enzymatic Conversion of Cellulose. In: "Biotechnology of Production
12
and Transformation of Fuels", VINITI PRESS, Moscow, 1983, p.63-150.
117.
Berezin, I.V., Klyosov, A.A. Enzyme Engineering. VESTNIK AN SSSR, 1983, No.
4, 108-119.
118.
Klyosov, A.A. Biocatalysis and Producing of Food from Non-Conventional
(Cellulosic) Sources. In:"Biocatalysis", NAUKA, Moscow, 1984, p.226-259.
119.
Klyosov, A.A. Application of Immobilized Enzymes in Food Industry.
In:"Biotechnologia" (ed. A.A.Bayev), NAUKA, Moscow, 1984, p.103-112.
120.
Klyosov, A.A. Enzymatic Conversion of Cellulose to Sugars and Alcohol: Present
State of the Art. PRIKL.BIOKHIM. MIKROBIOL., 21, 269-283, 1985.
121.
Klyosov, A.A. Enzymatic Conversion of Cellulose (Highlights: 1974 to 1984). Part I.
IZVESTIA AN SSSR, 1986, No.2, 190-200.
122.
Klyosov, A.A. Enzymatic Conversion of Cellulose (Highlights: 1974 to 1984). Part
II. IZVESTIA AN SSSR, 1987, No.1, 17-27.
123.
Klyosov, A.A. Enzymes of the Cellulase Complex. In: "Bioconversion of Plant
Materials", NAUKA, Moscow, 1986, 93-136.
124.
Klyosov, A.A. Enzymatic Conversion of Cellulose-Containing Materials into Sugars
and Liquid Fuel. GLAVMICROBIOPROM, Moscow, Separate edition, 1987, 44 p.
125.
Klyosov, A.A. Utilization of Cellulose-Containing Wastes Using Methods of Enzyme
Engineering. The STATE COMMITTEE ON SCIENCE AND TECHNOLOGY,
Moscow, Separate edition, 1985, 90 p.
126.
Klyosov, A.A. Enzymatic Conversion of Cellulosic Materials into Sugars and
Alcohol: Current State of the Problem. VINITI, Moscow, Separate edition, 1985, 42 p.
127.
Klyosov, A.A. Application of Enzyme Engineering in Food Industry. VNTIZENTR,
Moscow, Separate edition, 1986, 117 p.
128.
Klyosov, A.A. Angiogenin, a Protein Factor of Angiogenesis of Human Tumor Cells.
USPEKHI SOVR. BIOL. (Advances of the Modern Biology), 196, 264-278, 1988.
129.
Klyosov, A.A. Angiogenin, a Protein Inducing a Blood Supply to Tumor Cells.
In:"Science and Technology News", Ser. "Biotechnologia", No.1, VINITI PRESS, 1988, p.729.
130.
Klyosov, A.A., Grigorash, S.Yu. Kinetic Theory for Multienzyme Cellulase Systems:
Steady-State Kinetics. In: "Microbiology and Biochemistry of Degradation of Plant
Materials", NAUKA, Moscow, 1988, p. 109-146.
131.
Klyosov, A.A., Grigorash, S.Yu. Kinetic Theory for Multienzyme Cellulase Systems:
Non-Steady State Kinetics. In: "Microbiology and Biochemistry of Degradation of Plant
Materials", NAUKA, Moscow, 1988, p. 147-180.
132.
Rabinovich, M.L., Chernoglazov, V.M., Klyosov, A.A. Classification of Cellulases,
Their Sources, Multiple Forms and Mechanisms of Their Action. In:"Bioconversion of
Cellulose: Microbiology and Biochemistry", VINITI PRESS, Moscow, 1988, p. 1-149.
133.
Klyosov, A.A. Which Problems of Modern Biochemistry and Enzymology Seems to
be the Most Important and Interesting. Z. KHIM. OBS. im. D.I.Mendeleeva, 1989, No.1, p.
90-105.
134.
Klyosov, A.A. Biochemistry and Enzymology of Cellulose Hydrolysis. Biokhimiya,
1990, 55, No. 10, p. 1731-1765.
13
Peer_Review Papers In Russian:
135.
Berezin, I.V., Kazanskaya, N.F., Klyosov, A.A. Kinetics of alpha-Chymotrypsin and
Trypsin-Catalyzed Reactions in the Presence of Added Nucleophiles. BIOKHIMIYA, 36,
108-117, 1971.
136.
Berezin, I.V., Kazanskaya, N.F., Klyosov, A.A. Evidence for Non-Productive
Binding of Ester Substrates with the Active Site of alpha-Chymotrypsin. BIOKHIMIYA, 36,
227- 235, 1971.
137.
Klyosov, A.A. The Role of a Substrate Structural Factors in Reactions Catalyzed by
Chymotrypsin. Proceedings, Meeting of the Laboratory of Bioorganic Chemistry, Moscow
State University, 1971, p.261-272.
138.
Klyosov, A.A., Berezin, I.V. Use of Integrated Rate Equation for the Determination
of Kinetic Constants of Enzymatic Reactions. BIOKHIMIYA, 37, 170-183, 1972.
139.
Klyosov, A.A., Andreyev, V.M., Berezin, I.V. Effect of Promotion on Kinetics of
Solvolysis of Acetyl-Chymotrypsin Under the Action of Added Nucleophiles.
BIOKHIMIYA, 39, 1222-1230, 1974.
140.
Streltsova, Z.A., Klyosov, A.A., Svedas, V.K., et al. Effect of Polyelectrolytes on
Some Properties of Penicillin Amidase and Alkaline Phosphatase. BIOORGAN. KHIMIYA,
1, 1464-1469, 1975.
141.
Berezin, I.V., Klyosov, A.A., Svedas, V.K., Nys, P.S., Savitskaya, E.M. Kinetics of
Penicillin Amidase-Catalyzed Hydrolysis of Benzylpenicillin. ANTIBIOTIKI, 19, 880-887,
1974.
142.
Tsetlin, V.I., Ivanov, V.T., Ovchinnikov, Yu.A., Klyosov, A.A. Conformational
Aspects of Peptides Interaction with Proteolytic Enzymes. Alpha-Chymotrypsin Catalyzed
Hydrolysis of the Cyclopeptides Containing Leucyl-Tyrosyl Fragments. BIOKHIMIYA, 40,
484-488, 1975.
143.
Svedas, V.K., Klyosov, A.A., Nys, P.S., Savitskaya, E.M., Berezin, I.V. Studies on
Penicillin Amidase from E. coli. Kinetics of the Enzymatic Hydrolysis of 7Phenylacetamidodeacetoxycephalosporanic Acid. ANTIBIOTIKI, 21, 698-704, 1976.
144.
Berezin, I.V., Klyosov, A.A., Margolin, A.L., Nys, P.S., Savitskaya, E.M., Svedas,
V.K. Studies on Penicillin Amidase from E. coli. pH-Depencies of Kinetic Parameters of the
Enzymatic Hydrolysis of Benzylpenicillin. ANTIBIOTIKI, 21, 411-415, 1976.
145.
Berezin, I.V., Klyosov, A.A., Margolin, A.L., Nys, P.S., Savitskaya, E.M., Svedas,
V.K. Studies on Penicillin Amidase from E. coli. pH-Dependence of the Equilibrium
Constant for the Enzymatic Hydrolysis of Benzylpenicillin. ANTIBIOTIKI, 21, 519-523,
1976.
146.
Berezin, I.V., Klyosov, A.A., Rabinovich, M.L. Kinetics of Enzymatic Reactions in
Heterogeneous Systems. I. The Kinetic Regularities for the Bacterial Cell Micrococcus
lysodeikticus Degradation by Lysozyme. BIOORGAN. KHIMIYA, 2, 680-688, 1976.
147.
Rabinovich, M.L., Klyosov, A.A., Berezin, I.V. Kinetics of Enzymatic Reactions in
Heterogeneous Systems. II. Bacteriolytic Action of Lysozyme on Micrococcus
lysodeikticus Cells. BIOORGAN. KHIMIYA, 2, 689-699, 1976.
148.
Klyosov, A.A., Rabinovich, M.L., Berezin, I.V. Kinetics of Enzymatic Reactions in
Heterogeneous Systems. III. pH-Dependence of Hydrolysis of Bacterial Cells
14
Micrococcus lysodeikticus by Lysozyme. BIOORGAN. KHIMIYA, 2, 795-802, 1976.
149.
Klyosov, A.A., Berezin, I.V., Martinek, K., Klibanov, A.M., Svedas, V.K., Nys, P.S.,
Savitskaya, E.M. Studies on Penicillin Amidase from E. coli. Investigations into pH- and
Temperature Dependent Conformational Transitions at the Active Centre of the Enzyme by
Means of Ultrasound. ANTIBIOTIKI, 21, 31-34, 1976.
150.
Svedas, V.K., Margolin, A.L., Sherstyuk, S.F., Klyosov, A.A., Berezin, I.V.
Inactivation of Soluble and Immobilized Penicillin Amidase from E. coli by
Phenylmethanesulfonyl Fluoride: the Kinetic Analysis and Titration of the Enzyme Active
Sites. BIOORGAN. KHIMIYA, 3, 546-554, 1977.
151.
Klyosov, A.A., Galaev, I.Yu., Svedas, V.K. Study of the Active Center Topography
of Penicillin Amidase from E. coli. I. A Kinetic Analysis. BIOORGAN. KHIMIYA, 3, 663672, 1977.
152.
Klyosov, A.A., Svedas, V.K., Galaev, I.Yu. Study of the Active Center Topography
of Penicillin Amidase from E. coli. II. The Role of Hydrophobicity in the Specificity of the
Enzyme Inhibition. BIOORGAN. KHIMIYA, 3, 800-805, 1977.
153.
Klyosov, A.A., Margolin, A.L., Svedas, V.K. Enzymatic Synthesis of Antibiotics.
The Kinetics of Acyl Group Transfer onto 6-Aminopenicillanic Acid Catalyzed by Penicillin
Amidase from E. coli. BIOORGAN. KHIMIYA, 3, 654-662, 1977.
154.
Svedas, V.K., Margolin, A.L., Sherstyuk, S.F., Klyosov, A.A., Berezin, I.V.
Determination of the Molar Concentration of the Active Sites of Soluble and
Immobilized Penicillin Amidase. PROC. USSR ACAD. SCI., 232, 1127-1129, 1977.
155.
Klyosov, A.A., Vallee, B.L. Substrate Specificity and Kinetics of Carboxypeptidase
A Action: Role of a Metal of the Active Center in Specificity of Binding and Catalysis.
BIOORGAN. KHIMIYA, 3, 806-815, 1977.
156.
Klyosov, A.A., Vallee, B.L. Arsanilazotyrozine-248 Carboxypeptidase A: Circular
Dichroism Study of the Topography of the Enzyme Active Center. BIOORG.
KHIMIYA, 3, 964-980, 1977.
157.
Klyosov, A.A., Vallee, B.L. Magnetic Circular Dichroic Spectra of
Cobalt(II)Carboxypeptidase: Mutual Character of Interaction of Inhibitors with the Enzyme
Active Center. BIOORGAN. KHIMIYA, 3, 958-963, 1977.
158.
Klyosov, A.A., Vallee, B.L., Berezin, I.V. Specificity of Enzymatic Catalysis: alphaChymotrypsin and Carboxypeptidase A. Role of the Metal of the Active Site of the Enzyme
and Hydrophobic Character of the Substrate in the Specificity of Binding and Catalysis.
PROC. USSR ACAD. SCI., 234, 964-967, 1977.
159.
Klyosov, A.A. The Nature of Substrate Specificity of Trypsin. The Role of SideChain Positive Charge and Hydrophobicity in the Reactivity of Specific Substrates.
BIOORGAN. KHIMIYA, 3, 1100-1110, 1977.
160.
Klyosov, A.A., Lang, L.G., Sytkovski, A.G., Vallee, B.L. Unusual Character of the
Substrate Specificity of Alcohol Dehydrogenases of Different Origin. BIOORGAN.
KHIMIYA, 3, 1141-1144, 1977.
161.
Klyosov, A.A., Fedoseyev, V.N., Kirret, O.G. The Substrate Specificity of Trypsin.
The Interrelationship Between the Structure and Reactivity for Quasi-Substrates. Derivatives
of O-Alkylmethylphosphonic and Carboxylic Acids. BIOKHIMIYA, 42, 1939-1952, 1977.
162.
Klyosov, A.A. Alpha-Chymotrypsin and Trypsin Catalyzed Hydrolysis of Amino
15
Acid Esters Having Free alpha-Amino Group. pH-Dependence of the Individual Rate
Constants and the Stereospecificity. BIOORGAN. KHIMIYA, 3, 1512-1522, 1977.
163.
Klyosov, A.A., Tsetlin, V.I. The Implication of the Structural Factors in the Reaction
of Oligopeptide Substrates and Inhibitors with alpha-Chymotrypsin. BIOORGAN.
KHIMIYA, 3, 1523-1538, 1977.
164.
Klyosov, A.A., Berezin, I.V., Margolin, A.L., Stepanova, P.N., et al. Kinetics of the
Hydrolysis of N-Toluenesulphonyl-L-Arginine Methyl Ester and N-Benzoyl-L-Arginine
Ethyl Ester, Catalyzed by Tricholysine. PRIKL. BIOKHIM. MIKROBIOL., 13, 241- 247,
1977.
165.
Rabinovich, M.L., Klyosov, A.A., Berezin, I.V. Kinetics of the Action of Cellulolyti
Enzymes from Geotrichum candidum. Viscometric Analysis of the Carboxymethyl Cellulose
Hydrolysis. BIOORGAN. KHIMIYA, 3, 405-414, 1977.
166.
Nys, P.S., Savitskaya, E.M., Klyosov, A.A., Sinitsyn, A.P., Svedas, V.K., Berezin,
I.V. Studies on Penicillin Amidase from E. coli. pH-Dependence of the Enzyme
Inactivation Kinetics. ANTIBIOTIKI, 23, 46-50, 1978.
167.
Sinitsyn, A.P., Klibanov, A.M., Klyosov, A.A., Martinek, K. The Effect of the
Immobilization Method on the Stability of Immobilized Glucoamylase. PRIKL.
BIOKHIM. MIKROBIOL., 14, 236-242, 1978.
168.
Klyosov, A.A., Gerasimas, V.B. The Substrate Thermostabilization of Soluble and
Immobilized Glucoamylase. BIOKHIMIYA, 44, 1084-1092, 1979.
169.
Rabinovich, M.L., Klyosov, A.A., Berezin, I.V. The Mechanism of Glucose
Formation in the Course of the Enzymatic Hydrolysis of Cellulose Derivatives: the
Comparative Role of Exo-1,4-beta-Glucosidase and Cellobiase. PROC. USSR ACAD. SCI.,
246, 500-504, 1979.
170.
Klyosov, A.A., Rabinovich, M.L. The Comparative Characteristics of Cellulase
Complexes from Various Sources and Some Quantitative Criteria for an Optimal Enzyme
Preparation for the Conversion of Cellulose into Glucose. In "Biosynthesis of enzymes by
microorganisms. Purification, properties and immobilization of enzymes", Moscow, p. 393404, 1979.
171.
Churilova, I.V., Maximov, V.I., Klyosov, A.A. Cellobiose as a Regulator of
Endoglucanase Activity of Cellulase Complexes. The Mechanism of the Regulation.
BIOKHIMIYA, 44, 2100-2102, 1979.
172.
Gerasimas, V.B., Chernoglazov, V.M., Klyosov, A.A. The Effect of a Gradual
Chemical Modification on the Activity and the Thermal Stability of Soluble and Immobilized
Glucoamylase. BIOKHIMIYA, 45, 1086-1092, 1980.
173.
Klyosov, A.A., Churilova, I.V. A New Ultrasonic Method of Studying the
Composition and Properties of Multienzyme Systems: Enzymes of the Cellulase Complex.
BIOKHIMIYA, 45, 3-10, 1980.
174.
Klyosov, A.A., Grigorash, S.Yu. The Relationship Between Kinetics of the
Hydrolysis of Soluble and Native Cellulosics Under the Action of Cellulase Multienzyme
Complexes. BIOKHIMIYA, 45, 228-241, 1980.
175.
Churilova, I.V., Maximov, V.I., Klyosov, A.A. Purification and Properties of LowMolecular Weight Endoglucanase of Cellulase Complex from Trichoderma koningii.
BIOKHIMIYA, 45, 669-678, 1980.
16
176.
Klyosov, A.A., Churilova, I.V. Hydrolysis of Microcrystalline Cellulose by
Multienzyme Cellulase Complexes of Various Origin. BIOKHIMIYA, 45, 1685-1695, 1980.
177.
Klyosov, A.A., Rabinovich, M.L., Sinitsyn, A.P., Churilova, I.V., Grigorash, S.Yu.
Enzymatic Hydrolysis of Cellulose. I. Activity and Composition of Cellulase
Complexes from Various Sources. BIOORGAN. KHIMIYA, 6, 1225-1242, 1980.
178.
Klyosov, A.A., Rabinovich, M.L., Churilova, I.V., et al. Enzymatic Hydrolysis of
Cellulose. II. Properties of the Components of Cellulase Complexes from Various Sources.
BIORGAN. KHIMIYA, 6, 1377-1395, 1980.
179.
Sinitsyn, A.P., Agafonov, M.N., Khassanov, H.H., Rakhimov, M.M., Klyosov, A.A.
Conversion of Cellulose-Containing Materials to Glucose Using Cellulases of Different
Origin. PRIKL. BIOKHIM. MIKROBIOL., 16, 29-39, 1980.
180.
Churilova, I.V., Cherkasova, G.V., Velichko, B.A., Klyosov, A.A. Hydrolysis of
Corn Flour by the Amylase-Cellulase Complex. PRIKL. BIOKHIM. MIKROBIOL., 16,
296-299, 1980.
181.
Klyosov, A.A., Grigorash, S.Yu. Kinetics of the Action of Multienzyme Cellulase
Complexes on Insoluble Cellulose Derivatives. In: "Multienzyme Systems", VNIIPE,
Vilnius, 1980, 81-108.
182.
Klyosov, A.A., Sinitsyn, A.P., Nadjemi, B. The Enzymatic Conversion of Cellulose
to Glucose: the Effect of the Composition of a Multienzyme Cellulase Complex on the
Efficiency of the Hydrolysis of Cotton Linters. In: "Multienzyme Systems", VNIIPE, Vilnius,
1980, 109-125.
183.
Klyosov, A.P., Sinitsyn, A.P. Usage of Selective Inhibitors for Studying Kinetics and
Mechanism of Action of Multienzyme Cellulase Complexes. In: "Multienzyme Systems",
VNIIPE, Vilnius, 1980, 126-145.
184.
Klyosov, A.A., Grigorash, S.Yu. The Enzymatic Hydrolysis of Cellulose. III. The
Regularities of Glucose and Cellobiose Formation and the Action of Multienzyme Cellulase
Systems on Insoluble (Native) Cellulose. BIOORGAN. KHIMIYA, 7, 1538- 1552, 1981.
185.
Klyosov, A.A., Sinitsyn, A.P., Kovalev, G.V., Kalyazin, E.P., Bugaenko, L.T.,
Berezin, I.V. Effect of gamma-Irradiation of Native Cellulose on Efficiency of its Enzymatic
Hydrolysis: the Role of Degree of Polymerization and Crystallinity. PROC. USSR ACAD.
SCI., 259, 1495-1497, 1981.
186.
Klyosov, A.A., Rabinovich, M.L., Chernoglazov, V.M., Nguen Van Viet, Berezin,
I.V. The Effectiveness of Adsorption of Cellulolytic Enzymes as a Factor Which Determines
the Reactivity of Insoluble (Crystalline) Cellulose. PROC. USSR ACAD. SCI., 260, 14811486, 1981.
187.
Klyosov, A.A., Berezin, I.V. The Enzymatic Conversion of Cellulose to Glucose:
Kinetics and Mechanism of Action of the Cellulase Complex. In: "Cellulases of
Microorganisms", NAUKA, Moscow, 1981, 73-82.
188.
Klyosov, A.A., Grigorash, S.Yu. The Effect of Composition of Multienzyme
Cellulase Complexes on Rate-Limiting Steps for Non-Soluble (Native) Cellulose Hydrolysis.
BIOKHIMIYA, 46, 110-119, 1981.
189.
Sinitsyn, A.P., Klyosov, A.A. A Comparative Role of Exo-1,4-beta-Glucosidase and
Cellobiase in the Enzymatic Hydrolysis of Cellulose. BIOKHIMIYA, 46, 202-213, 1981.
190.
Sinitsyn, A.P., Klyosov, A.A. The Influence of a Pretreatment of Cotton Linters on
17
the Efficiency of the Enzymatic Conversion. PRIKL. BIOKHIM. MIKROBIOL., 17, 682695, 1981.
191.
Sinitsyn, A.P., Nadjemi, B., Klyosov, A.A. The Enzymatic Conversion of Cellulose
to Glucose: the Effect of Product Inhibition and Decrease of Substrate Reactivity on the Rate
of the Enzymatic Hydrolysis. PRIKL. BIOKHIM. MIKROBIOL., 17, 315- 327, 1981.
192.
Klyosov, A.A., Devdariani, T.G., Mudziri, L.A. Stability of Soluble and Immobilize
Cellulases in Water-Alcohol Systems. PRIKL. BIOKHIM. MIKROBIOL., 17, 216- 224,
1981.
193.
Klyosov, A.A., Sinitsyn, A.P. The Enzymatic Hydrolysis of Cellulose. IV. The Effect
of Major Physico-Chemical and Structural Features of the Substrate. BIOORGAN.
KHIMIYA, 7, 1801-1812, 1981.
194.
Klyosov, A.A., Parbuzin, V.S., Rabinovich, M.L. The Enzymatic Conversion of
Polymers. The Nature of an Apparent Product Inhibition in the Course of the Enzymatic
Degradation of Polymer Substrates. BIOKHIMIYA, 46, 1840-1846, 1981.
195.
Ivanova, I.I., Guzhova, E.P., Sinitsyn, A.P., Burdenko, L.G., Loginova, L.G.,
Klyosov, A.A. Some Properties of the Cellulase Preparation Celloterrine. PRIKL.
BIOKHIM. MIKROBIOL., 18, 60-64, 1982.
196.
Klyosov, A.A., Grigorash, S.Yu. Non-Steady State Kinetics for the Action of a
Multienzyme Cellulase System Toward an Insoluble Cellulose. BIOKHIMIYA, 47, 240-256,
1982.
197.
Klyosov, A.A., Grigorash, S.Yu. The Enzymatic Hydrolysis of Cellulose. The
Regulatory Effect of an Insoluble Substrate on the Effectiveness of the Enzymatic Reaction.
BIOKHIMIYA, 47, 409-418, 1982.
198.
Rabinovich, M.L., Nguen Van Viet, Klyosov, A.A. Adsorption of Cellulolytic
Enzymes on Cellulose and Kinetics of the Adsorbed Enzymes. Two Types of Interactions of
the Enzymes with the Insoluble Substrate. BIOKHIMIYA, 47, 465-477, 1982.
199.
Klyosov, A.A. The Regularities for Formation and Conversion of Intermediate
Cellooligosaccharides and Cellobiose in the Course of the Enzymatic Hydrolysis of the
Insoluble Cellulose. BIOKHIMIYA, 47, 608-618, 1982.
200.
Rabinovich, M.L., Klyosov, A.A., Grigorash, S.Yu., Kalnina, I.A., Chernoglazov,
V.M. The Enzymatic Hydrolysis of Cellulose. VI. Adsorption of Cellobiase. BIOORGAN.
KHIMIYA, 8, 84-95, 1982.
201.
Rabinovich, M.L., Martianov, V.A., Chumak, G.A., Klyosov, A.A. The Substituted
Cellodextrine, a New Substrate for the Selective Assay of Exo-1,4-beta-Glucosidase in
Cellulase Complexes. BIOORGAN. KHIMIYA, 8, 396-403, 1982.
202.
Klyosov, A.A., Chernoglazov, V.M., Rabinovich, M.L., Sinitsyn, A.P. The Role of
Endoglucanase Adsorptivity in the Degradation of Crystalline and Amorphous Cellulose.
BIOORGAN. KHIMIYA, 8, 643-651, 1982.
203.
Gusakov, A.V., Sinitsyn, A.P., Klyosov, A.A. The Enzymatic Degradation of
Cellulose. Inactivation and Stabilization of the Individual Components of Cellulase
Complexes. BIOKHIMIYA, 47, 1322-1331, 1982.
204.
Klyosov, A.A., Rabinovich, M.L., Churilova, I.V., Martianov, V.A., Gusakov, A.V.,
Elyakova, L.A. The Enzymatic Hydrolysis of Cellulose. V. Cellulases in Marine Organisms
of the Sea of Japan. BIOORGAN. KHIMIYA, 8, 1490-1496, 1982.
18
205.
Sinitsyn, A.P., Najemi, B., Klyosov, A.A. The Enzymatic Conversion of Cellulose
Glucose. The Effect of Composition of a Cellulase Preparation on the Efficiency of Cotton
Linters Hydrolysis. CHEMISTRY OF WOOD, No.2, 91-96, 1982.
206.
Datunashvili, E.N., Klyosov, A.A., Gerzhikova, V.G., Ezhov, V.N., Sadykov, I.I.
The Hydrolysis of Different Fractions of Polysaccharides from the Grape Skin by the
Cellulase Preparation Cellokoningin P10X. PRIKL. BIOKHIM. MIKROBIOL., 18, 699-704,
1982.
207.
Rabinovich, M.L., Chernoglazov, V.M., Klyosov, A.A. Isoenzymes of
Endoglucanases in Cellulase Complexes: Various Affinity for Cellulose and Different Role
in the Hydrolysis of the Insoluble Substrate. BIOKHIMIYA, 48, 369-377, 1983.
208.
Adamenkova, M.D., Glazov, M.V., Klyosov, A.A. Some Physico-Chemical
Regularities in a Behavior of Enzymes Adsorbed on their Substrates. ZH. PHYS. KHIM., 57,
1329-1336, 1983.
209.
Klyosov, A.A., Chernoglazov, V.M., Rabinovich, M.L., Glazov, M.V., Adamenkova
M.D. The Ability of Cellulases to Degrade the Crystalline Cellulose as a Result of their
Ability to be Adsorbed onto the Substrate: Experimental Verification and Theoretical
Interpretation. BIOKHIMIYA, 48, 1411-1420, 1983.
210.
Chernoglazov, V.M., Klyosov, A.A., Ermolova, O.V. The Action of Isoenzymes of
Endoglucanase from Trichoderma longibrachiatum, Which Differ in their Ability to be
Adsorbed on Cellulose, Toward Soluble, Amorphous and Crystalline Cellulose: Different
Role of the Efficiency of the Adsorption. BIOKHIMIYA, 48, 1617-1623, 1983.
211.
Sinitsyn, A.P., Klyosov, A.A., Marupov, R.M., Likhtenstein, G.I. The Enzymatic
Hydrolysis of Cotton Fibres from Unspoiled and Vilt-Spoiled Plants. PRIKL.
BIOKHIM. MIKROBIOL., 19, 413-415, 1983.
212.
Rabinovich, M.L., Buachidze, T.S., Klyosov, A.A., Kvesitadze, G.I. Thermostability
of the Intracellular Cellobiase of Thermomonospora sp. PRIKL. BIOKHIM.
MIKROBIOL., 19, 779-782, 1983.
213.
Martianov, V.A., Rabinovich, M.L., Klyosov, A.A., Myagkich, I.V., Gernet, M.V.
Affinity Chromatography of Cellulases on Cellulosic Carriers. PRIKL. BIOKHIM.
MIKROBIOL., 19, 513-520, 1983.
214.
Gusakov, A.V., Sinitsyn, A.P., Klyosov, A.A. The Enzymatic Conversion of
Cellulose to Glucose in a Column Reactor. Comparative Characterization of Various
Cellulase Preparations. PRIKL. BIOKHIM. MIKROBIOL., 19, 764-773, 1983.
215.
Bulygin, A.N., Roshin, O.A., Bulygina, L.A., Pasechnik, V.A., Khalyapin, B.D.,
Shtukina, T.V., Klyosov, A.A. Mathematical Modelling of Flow-Through Tubular
Extracorporal Shunts with Immobilized Enzymes. A Comparison of the Theory with the
Experiment. PRIKL. BIOKHIM. MIKROBIOL., 20, 230-235, 1984.
216.
Gusakov, A.V., Nadjemi, B., Sinitsyn, A.P., Klyosov, A.A. The Enzymatic
Hydrolysis of Cellulose: the Comparison of the Efficiency of Reactors of Various Types.
PRIKL. BIOKHIM. MIKROBIOL., 20, 55-63, 1984.
217.
Bolobova, A.V., Rabinovich, M.L., Klyosov, A.A. A Rapid Method for
Determination of Cellobiase Activity. PRIKL. BIOKHIM. MIKROBIOL., 20, 280-284,
1984.
218.
Sinitsyn, A.P., Kovalev, G.V., Mesa-Manresa, S.R., Kozlovski, D.F., Kalyazin, E.P.,
19
Klyosov, A.A. A Comparative Study of Various Pretreatments in Relation to the
Efficiency of the Enzymatic Hydrolysis of Cellulose-Containing Materials.
CHEMISTRY OF WOOD, No.5, 60-71, 1984.
219.
Rabinovich, M.L., Klyosov, A.A., Berezin, I.V. The Mechanism of the Transfer of a
Enzyme Adsorbed on an Insoluble Substrate Surface. PROC. USSR ACAD. SCI., 274, 758763, 1984.
220.
Klyosov, A.A., Mitkevich, O.V., Sinitsyn, A.P., Berezin, I.V. Role of the Activity and
Adsorption Ability of Cellulases in the Efficiency of the Enzymatic Hydrolysis of
Amorphous and Crystalline Cellulose. PROC. USSR ACAD. SCI., 277, 999-1002, 1984.
221.
Gusakov, A.V., Sinitsyn, A.P., Klyosov, A.A., Goldsteins, G.H. Hydrolysis and
Transglycosylation Reactions Catalyzed by Cellobiase. Kinetics and Mathematical Model of
the Process. BIOKHIMIYA, 49, 1110-1120, 1984.
222.
Rabinovich, M.L., Melnik, M.S., Badalov, A.B., Klyosov, A.A., Berezin, I.V.
Evolution of the Enzyme-Substrate Interactions in the Course of the Enzymatic Hydrolysis of
Cellulose. PROC. USSR ACAD. SCI., 282, 1013-1017, 1985.
223.
Chernoglazov, V.M., Ermolova, O.V., Klyosov, A.A. Affinity Chromatography and
High Performance Chromatofocusing. Purification and Characterization of Multiple Forms
of Endoglucanases from Trichoderma viride with Different Adsorption Ability on Cellulose.
BIOKHIMIYA, 50, 1108-1119, 1985.
224.
Rabinovich, M.L., Melnik, M.S., Klyosov, A.A. Titration of Active Centers of
Enzymes: Cellobiohydrolase of the Cellulase Complex. BIOKHIMIYA, 50, 1499-1503,
1985.
225.
Rabinovich, M.L., Savitskene, R.Yu., Klyosov, A.A., et al. A Dyed Substrate of
Cellulases: Fields of Application. BIOORGAN. KHIMIYA, 11, 1330-1342, 1985.
226.
Rabinovich, M.L., Novikova, T.V., Klyosov, A.A., Berezin, I.V. The Specificity of
Adsorption of Trichoderma reesei Cellobiohydrolase I on Cellulose Derivatives.
BIOORGAN. KHIMIYA, 11, 1343-1347, 1985.
227.
Mitkevich, O.V., Sinitsyn, A.P., Klyosov, A.A. On the Mechanism of the Action of
Multienzyme Cellulolytic Preparations on Soluble Cellulose. PRIKL. BIOKHIM.
MIKROBIOL., 21, 213-218, 1985.
228.
Sinitsyn, A.P., Nadjemi, B., Klyosov, A.A. The Role of the Individual Components
of the Cellulase Complex on the Kinetics of Cellulose Hydrolysis. PRIKL. BIOKHIM.
MIKROBIOL., 21, 324-329, 1985.
229.
Bolobova, A.V., Klyosov, A.A., Rabinovich, M.L. The Substitution Degree of
Carboxymethyl Cellulose Does Not Affect the Results of the Viscometric Assay of the
Endoglucanase Activity of Cellulase Complexes. PRIKL. BIOKHIM. MIKROBIOL., 21,
805-813, 1985.
230.
Ernst, L.K., Bolobova, A.V., Klyosov, A.A. The Mode of Action of the Ruminant
Paunch Bacterial Cellulases. VESTNIK SELSKOKHOS. NAUKI, No.9, 94-99, 1985.
231.
Klyosov, A.A., Chernoglazov, V.M., Ermolova, O.V., Elkin, V.V. Effect of Lignin on
the Enzymatic Hydrolysis of Lignin-Containing Materials. BIOTECHNOLOGIA, No.3, 106112, 1985.
232.
Gusakov, A.V., Sinitsyn, A.P., Klyosov, A.A. A Kinetic Model of the Enzymatic
Hydrolysis of Cellulose in a Column-Type Reactor. BIOTECHNOLOGIA, No.3, 112- 122,
20
1985.
233.
Klyosov, A.A., Kude, E., Goldsteins, G.H. The Relative Role of the Individual
Components of the Cellulase Complex from Trichoderma reesei in the Multienzymatic
Hydrolysis of the Insoluble Cellulose. BIOTECHNOLOGIA, No.6, 59-69, 1985.
234.
Nuzubidze, N.N., Klyosov, A.A., Todorov, P.T. The Kinetics and Mechanism of
Inhibition of Cellulases from Various Sources by the Product of the Enzymatic
Hydrolysis of Cellulose. BIOTECHNOLOGIA, No.6, 69-76, 1985.
235.
Vlasenko, E.Yu., Sinitsyn, A.P., Scherbukhin, V.D., Klyosov, A.A. The Hydrolysis of
Plant Glucomannanes by the Preparations of Cellulase from Trichoderma reesei and
Mannanase from Bacillus subtilis. BIOTECHNOLOGIA, No.6, 76-83, 1985.
236.
Klyosov, A.A., Bolobova, A.V., Ostrovskaya, M.V., Poglazov, B.F. Activation of
Cellulases from Different Sources by Actin. BIOKHIMIYA, 51, 188-194, 1986.
237.
Maryanovskaya, I.G., Rabinovich, M.L., Kulaev, I.S., Klyosov, A.A. A Kinetic
Mechanism of beta-Glucosidase from Aspergillus foetidus: Evidence on the Existence of
Two Different Binding Sites for Cellobiose and p-Nitrophenyl-beta-D-Glucopyranoside.
BIOKHIMIYA, 51, 1986.
238.
Gusakov, A.V., Sinitsyn, A.P., Klyosov, A.A. A Mathematical Model for the
Enzymatic Hydrolysis of Cellulose in a Batch Reactor. PRIKL. BIOKHIM. MIKROBIOL.,
22, 59-69, 1986.
239.
Rabinovich, M.L., Nguen Van Viet, Klyosov, A.A. Synergism Under Concerted
Action of Endoglucanases with Low and High Affinity for Cellulose. PRIKL. BIOKHIM.
MIKROBIOL., 22, 70-79, 1986.
240.
Klyosov, A.A. Cellulases of the Caribbean Sea. PRIKL. BIOKHIM. MIKROBIOL.,
22, 193-197, 1986.
241.
Sinitsyn, A.P., Nadjemi, B, Mitkevich, O.V., Klyosov, A.A. The Mutual Increasing
the Hydrolytic Effects of Tightly and Weakly Adsorbed Cellulases. PRIKL.
BIOKHIM. MIKROBIOL., 22, 333-336, 1986.
242.
Sinitsyn, A.P., Leonova, I.Yu., Nadjemi, B., Klyosov, A.A. A Comparative Analysis
of the Reactivity of Cellulosic Materials in Relation to the Enzymatic Hydrolysis. PRIKL.
BIOKHIM. MIKROBIOL., 22, 517-525, 1986.
243.
Klyosov, A.A., Grigorash, S.Yu., Gromov, A.I. Mathematical Modelling of the
Kinetics of the Multienzyme Hydrolysis of the Insoluble Cellulose. PRIKL. BIOKHIM.
MIKROBIOL., 22, 612-621, 1986.
244.
Sinitsyn, A.P., Mitkevich, O.V., Klyosov, A.A. The Inactivation of Cellulolytic
Enzymes by Stirring and their Stabilization by Cellulose. PRIKL. BIOKHIM. MIKROBIOL.,
22, 759-765, 1986.
245.
Klyosov, A.A. Enzyme Engineering: Advances and Lessons. ANTIB. MED.
BIOTECHNOL., No.2, 89-93, 1986.
246.
Gusakov, A.V., Sinitsyn, A.P., Klyosov, A.A. The Efficiencies of Batch and
Continuous Reactors for the Enzymatic Hydrolysis of Cellulose as Compared Relying on the
Kinetic Computations: the Effect of Various Factors. BIOTECHNOLOGIA, No.1, 74-84,
1986.
247.
Tikhomirov, D.F., Nuzubidze, N.N., Klyosov, A.A. The Hydrophobic
Chromatography of Endo-1,4-beta-Glucanase from the Cellulase Complex of Trichoderma
21
reesei on Toyopearl HW-65F Carrier. BIOTECHNOLOGIA, No.4, 58-64, 1986.
248.
Morozov, A.M., Rabinovich, M.L., Klyosov, A.A. Biotechnology of the Continuous
Enzymatic Hydrolysis of Cellulose. I. Basic Aspects of the Technology.
BIOTECHNOLOGIA, No.4, 71-81, 1986.
249.
Rainina, E.I., Bachurina, G.P., Machlis, T.A., Sinitsyn, A.P., Klyosov, A.A. Using
Zymomonas mobilis Bacteria for the Fermentation of Cellulosic Materials.
BIOTECHNOLOGIA, No.4, 65-70, 1986.
250.
Kraeva, N.E., Rabinovich, M.L., Klyosov, A.A., Berezin, I.V. The Activation by
Cellulose and its Derivatives of Degradation of Low-Molecular Weight Chromogenic
Substrate Catalyzed by Endoglucanase from Trichoderma viride. PROC. USSR ACAD. SCI.,
290, 484-486, 1986.
251.
Rabinovich, M.L., Melnik, M.S., Novikova, T.V., Klyosov, A.A., et al. pNitrophenyl-beta-D-Lactoside as a Substrate for the Continuous Determination of
Cellobiohydrolase I in Cellulase Complexes. BIOORGAN. KHIMIYA, 12, 1549-1560, 1986.
252.
Morozov, A.M., Rabinovich, M.L., Klyosov, A.A. Biotechnology of the Continuous
Enzymatic Hydrolysis of Cellulose. II. Hydrodynamic Resistance of the Column Apparatus.
BIOTECHNOLOGIA, No.5, 52-59, 1986.
253.
Klyosov, A.A. Computer Conferences as a New Tool for Scientific Communications
VESTNIK AN SSSR, No.10, 56-62, 1986.
254.
Tikhomirov, D.F., Nuzubidze, N.N., Lakhtin, V.M., Klyosov, A.A. Isolation of
Multiple Forms of Trichoderma reesei Endoglucanase Posessing High Hydrophobicity.
BIOKHIMIYA, 52, 1097-1106, 1987.
255.
Klyosov, A.A., Ermolova, O.V., Chernoglazov, V.M., Loginova, L.G., Guzhova, E.P.
The Thermostable Endo-1,4-beta-Glucanase from Myceliophthora thermophila:
Purification and Characterization. PRIKL. BIOKHIM. MIKROBIOL., 23, 44-49, 1987.
256.
Morozov, A.M., Klyosov, A.A., Gluschenko, E.V., Badalov, A.B., Rabinovich, M.L.
Biotechnology of the Continuous Enzymatic Hydrolysis of Cellulose.III. The
Enzymatic Production of Glucose from Cellulosic Materials in the Pilot Plant.
BIOTECHNOLOGIA, No.1, 31-38, 1987.
257.
Sinitsyn, A.P., Mitkevich, O.V., Kalyuzhnyi, S.V., Klyosov, A.A. A Study on
Synergism in the Action of the Enzymes of a Cellulase Complex. BIOTECHNOLOGIA,
No.1, 39-46, 1987.
258.
Klyosov, A.A. Cellulases of the Third Generation. BIOTECHNOLOGIA, 3, 132-138,
1987.
259.
Klyosov, A.A., Rabinovich, M.L., Nuzubidze, N.N. et al. Molecular Screening of
Cellulases: Catalytic Activity, Thermostability, Product Inhibition, and Adsorption Capacity.
BIOTECHNOLOGIA, 3, 152-168, 1987.
260.
Klyosov, A.A. On the Three Unsolved Fundamental Problems of Enzymatic
Production of Sugars from Plant Materials. BIOTECHNOLOGIA, 3, 549-552, 1987.
261.
Sinitsyn, A.P., Mitkevich, O.V., Klyosov, A.A. The Changes in Reactivity and
Physico-Chemical Parameters of Cellulose During its Enzymatic Hydrolysis.
BIOTECHNOLOGIA, 3, 640-649, 1987.
262.
Nuzubidze, N.N., Prabakaran, K., Dzhafarova, A.N., Sokolovski, V.Yu., Krizky,
M.S., Klyosov, A.A. Intergeneric Fusion of Fungal Protoplasts Trichoderma viride and
22
Neurospora crassa. PROC. USSR ACAD. SCI., 300, 488-490, 1988.
263.
Tikhomirov, D.F., Fetisova, V.V., Simankova, M.V., Klyosov, A.A. Endo-1,4-betaGlucanase of the Anaerobic Thermophilic Bacterium Clostridium thermocellum Under
Conditions of the Degradation of the Multienzyme Clasters. BIOKHIMIYA, 53, 758-767,
1988.
264.
Klyosov, A.A., Nuzubidze, N.N., Todorov, P.T. Endo-1,4-beta-Glucanase (Cellulase
from the Thermophilic Bacterium Clostridium thermocellum. PRIKL. BIOKHIM.
MIKROBIOL., 24, 28-34, 1988.
265.
Bolobova, A.V., Kornilova, I.G., Simankova, M.V., Klyosov, A.A. Cellulases of
Clostridium thermocellum. PRIKL. BIOKHIM. MIKROBIOL., 24, 342-352, 1988.
266.
Ermolova, O.V., Bolobova, A.V., Kornilova, I.G., Golovchenko, N.P., Klyosov, A.A.
Characterization of Endo-1,4-beta-Glucanases of Clostridium thermocellum F7.
PRIKL. BIOKHIM. MIKROBIOL., 24, 622-629, 1988.
267.
Nuzubidze, N.N., Prabakaran, K., Dzhafarova, A.N., Klyosov, A.A. Isolation of
Protoplasts from the Cellulolytic Fungus Trichoderma viride QM 9414. PRIKL.
BIOKHIM. MIKROBIOL., 24, 725-729, 1988.
268.
Tikhomirov, D.F., Stolbova, V.V., Klyosov, A.A. Endo-1,4-beta-Glucanases of the
Anaerobic Bacterium Clostridium thermocellum St. No. 3 with a High Heat Stability.
PRIKL. BIOKHIM. MIKROBIOL., 25, 48-55, 1989.
269.
Chernoglazov, V.M., Ermolova, O.V., Klyosov, A.A. Adsorption of Highly Purified
Endo-1,4-beta-Glucanases of Trichoderma reesei on the Components of Lignocellulosic
Material: Cellulose, Lignin, and Xylan. PRIKL. BIOKHIM. MIKROBIOL., 25, 333-342,
1989.
270.
Vlasenko, E.Yu., Papkovskaya, N.Yu., Sinitsyn, A.P., Scherbukhin, V.D., Klyosov,
A.A. Hydrolysis of Mannose-Containing Polysaccharides by Endo-1,4-beta-Glycanases.
PRIKL. BIOKHIM. MIKROBIOL., 25, 604-613, 1989.
271.
Tikhomirov, D.F., Stolbova, V.V., Prabakaran, K., Klyosov, A.A. Application of
Soluble Dyed Substrate OC-41 for Endo-1,4-beta-Glucanase Activity Assay.
BIOTECHNOLOGIA, 5, 518-524, 1989.
272.
Melnik, M.S., Rabinovich, M.L., Klyosov, A.A. A New Type of Clostridium
thermocellum Endoglucanase Produced by the Recombinant Strain of E. coli:
Purification and Separation of Multiple Forms. BIOKHIMIYA, 54, 284-291, 1989.
273.
Melnik, M.S., Kapkov, D.V., Mogutov, M.A., Rabinovich, M.L., Klyosov, A.A. A
New Type of Clostridium thermocellum Endoglucanase Produced by the Recombinant Strain
of E. coli: Some Properties and Identification in Donor Cells. BIOKHIMIYA, 54, 387-396,
1989.
274.
Tsarev, A.P., Izotov, D.N., Kazantsev, I.Ya., Klyosov, A.A., et al. Forest FastGrowing Species Breeding for Plantations. In: FOREST GENETICS, BREEDING AND
PHYSIOLOGY OF WOODY PLANTS. Moscow, 1989, p.131-141.
275.
Dzhafarova, A.N., Nuzubidze, N.N., Klyosov, A.A. Preparation of Protoplasts fro
Thermophilic Fungus Myceliophthora thermophila. PRIKL. BIOKHIM. MIKROBIOL., 26,
126-127, 1990.
276.
Bolobova, A.V., Klyosov, A.A. Comparison of the Efficiency of the Microcrystalline
Cellulose Hydrolysis with Bacterial and Fungal Cellulases. PRIKL. BIOKHIM.
23
MICROBIOL., 26, 321-327, 1990.
277.
Bolobova, A.V., Klyosov, A.A. The Behavior of Clostridium thermocellum
Cellulosomes in Cellulose Hydrolysis Recorded by Scanning Electron Microscopy.
MIKROBIOLOGIA, 60, 321-327, 1991.
278.
Komolova, G.S., Mashtakova, A.D., Klyosov, A.A. Quantitative Evaluation of the
Angiogenin Biological Activity. IZV. AN SSSR, Ser. Biol., No. 5, p. 684-689, 1992.
279.
Tevyashova, A.N., Olsufyeva, E.N., Preobrazhenskaya, M.N., Klyosov, A.A., Zomer,
E., Platt, D. New Conjugates of an Antitumor Antibiotics Doxorubicin with a Water-soluble
Galactomannan: Synthesis and Biological Activity. Bioorganic Chemistry (Moscow, in
Russian), v. 33, No. 1, pp. 1 - 8 (2007)
PEER-REVIEW PAPERS In German:
280.
Richter, P., Klyosov, A.A. Hemmung von Chymotrypsin durch Benzamidin Derivate.
DIE PHARMAZIE, 31, 192-193, 1976.
281.
Klyosov, A.A., Kude, J., Goldstein, G.Ch., Meyer D. Rolle der Einzelnen
Komponenten des Cellulasekomplexes bei der Hydrolyse Unloslicher Cellulose. ACTA
BIOTECHNOL., 6, 369-379, 1986.
PEER-REVIEW PAPERS IN ENGLISH.
282.
Berezin, I.V., Kazanskaya, N.F., Klyosov, A.A. Determination of the Individual Rate
Constants of Chymotrypsin-Catalysed Hydrolysis With the Added Nucleophylic Agent, 1,4Butanediol. FEBS LETTERS, 15, 121-124, 1971.
283.
Berezin, I.V., Kazanskaya, N.F., Klyosov, A.A., Martinek, K. On the Relationship
Between Structure and Reactivity of Chymotrypsin Substrates. FEBS LETTERS, 15, 125128, 1971.
284.
Dorovska, V.N., Varfolomeev, S.D., Kazanskaya, N.F., Klyosov, A.A., Martinek, K.
The Influence of the Geometric Properties of the Active Centre on the Specificity of
Chymotrypsin Catalysis. FEBS LETTERS, 23, 122-124, 1972.
285.
Berezin, I.V., Kazanskaya, N.F., Klyosov, A.A., Svedas, V.K. The Mechanism of the
Chymotrypsin and Trypsin-Catalysed Hydrolysis of Amides. Evidence for the Participation
of the Active Serine in the Amidase Activity of Trypsin. EUR. J. BIOCHEM., 38, 529-536,
1973.
286.
Martinek, K., Klyosov, A.A., Kazanskaya, N.F., Berezin, I.V. The Free EnergyReaction Coordinate Profile for Chymotrypsin Hydrolysis of a Series of N-Acetyl-L-Amino
Acid Methyl Esters. INTERN. J. CHEM. KINETICS, 6, 801-811, 1974.
24
287.
Berezin, I.V., Klibanov, A.M., Klyosov, A.A., Martinek, K., Svedas, V.K. The Effect
of Ultrasound as a New Method of Studying Conformational Transitions in Enzyme Active
Sites. pH- and Temperature-Induced Conformational Transitions in the Active Centre of
Penicillin Amidase. FEBS LETTERS, 49, 325-328, 1975.
288.
Klyosov, A.A., Nguen Van Viet, Berezin, I.V. The Reactions of Chymotrypsin and
Related Proteins with Ester Substrates in Non-Aqueous Solvents. EUR. J. BIOCHEM., 59,
3-7, 1975.
289.
Johansen, J.T., Klyosov, A.A., Vallee, B.L. Circular Dichroism - Inhibitor Titrations
of Arsanilazotyrozine-248 Carboxypeptidase A. BIOCHEMISTRY, 15, 296-303, 1976.
290.
Klyosov, A.A. The Kinetics and Mechanism of Action of Cellulases from
Geotrichum candidum. ADV. ENZYME ENGINEERING II: PROC.SECOND JOINT
US/USSR ENZYME ENGINEERING SEMINAR, CORNING, 263-281, 1977.
291.
Klyosov, A.A. Use of Immobilized Enzymes in Organic Synthesis (with the Example
of Penicillin Amidase from E. coli). ADV. ENZYME ENGINEERING II:
PROC.SECOND JOINT US/USSR ENZYME ENGINEERING SEMINAR,
CORNING, 283-305, 1977.
292.
Klyosov, A.A. The Study of Kinetics and Mechanism of Action of Cellulolytic
Enzymes. PROC.THIRD JOINT US/USSR ENZYME ENGINEERING SEMINAR,
NATIONAL SCIENCE FOUNDATION, 378-409, 1978.
293.
Klyosov, A.A., Gerasimas, V.B. The Thermostability of Glucoamylase Immobilized
in Different Ways Has a Certain Limit. BIOCHIM.BIOPHYS.ACTA, 571, 162-165, 1979.
294.
Klyosov, A.A., Gerasimas, V.B., Sinitsyn, A.P. Substrates Stabilization of Soluble
and Immobilized Glucoamylase Against Heating. In: ENZYME ENGINEERING FUTURE DIRECTIONS (L.B.Wingard, I.V.Berezin, A.A.Klyosov, eds), PLENUM PRESS,
New York, 197-215, 1980.
295.
Wingard, L.B., Klyosov, A.A. Some Thoughts of the Future of Enzyme Engineering.
In: ENZYME ENGINEERING - FUTURE DIRECTIONS (L.B.Wingard, I.V.Berezin,
A.A.Klyosov, eds), PLENUM PRESS, New York, 499-506, 1980.
296.
Klyosov, A.A., Sinitsyn, A.P., Rabinovich, M.L. The Comparative Role of
Exoglucosidase and Cellobiase in Glucose Formation from Cellulose. In: ENZYME
ENGINEERING, v. (H.H.Weetall, G.P.Royer, eds), PLENUM PRESS, New York, 153-165,
1980.
297.
Klyosov, A.A. Enzymatic Conversion of Cellulose to Glucose: Kinetics, Mechanism
and Applied Problems. In: FOOD PROCESS ENGINEERING, v.2. ENZYME
25
ENGINEERING IN FOOD PROCESSING (P.Linko, J.Larinkari, eds), APPL. SCI. PUBL.,
LONDON, 246-256, 1980.
298.
Klyosov, A.A. Structure and Properties of Multienzyme Cellulase System. In:
SECOND INTERNATIONAL SYMPOSIUM ON BIOCONVERSION AND
BIOCHEMICAL ENGINEERING, Skylark Printers, New Delhi, 16-20, 1980.
299.
Rabinovich, M.L., Klyosov, A.A. Comparative Role of Components of Cellulase
Complex. In: SECOND INTERNATIONAL SYMPOSIUM ON BIOCONVERSION AND
BIOCHEMICAL ENGINEERING, Skylark Printers, New Delhi, 24-28, 1980.
300.
Rabinovich, M.L., Klyosov, A.A. Role of Adsorption of Cellulases on Cellulose. In:
SECOND INTERNATIONAL SYMPOSIUM ON BIOCONVERSION AND
BIOCHEMICAL ENGINEERING, Skylark Printers, New Delhi, 53-56, 1980.
301.
Klyosov, A.A. Structure, Function and Regulation of Multienzyme System of a
Cellulase Complex. PROC. 5th US/USSR ENZYME ENGINEERING CONFERENCE,
RIGA, 50-65, 1980.
302.
Berezin, I.V., Klyosov, A.A. Enzymes Attack Cellulose. SCIENCE IN USSR, No.3,
6-15, 1981.
303.
Klyosov, A.A. Biotechnology of the Enzymatic Conversion of Cellulose into
Glucose: Fundamental and Applied Aspects. In: BIOCONVERSION OF PLANT RAW
MATERIALS BY MICROORGANISMS. PROC. FINNISH-SOVIET SYMPOSIUM,
HELSINKI, 152-178, 1983.
304.
Gusakov, A.V., Sinitsyn, A.P., Goldsteins, G.H., Klyosov, A.A. Kinetics and
Mathematical Model of Hydrolysis and Transglycosylation Catalyzed by Cellobiase.
ENZYME MICROB. TECHNOL., 6, 275-282, 1984.
305.
Klyosov, A.A., Rabinovich, M.L., Morozov, A.M. Biotechnology of the Continuous
Enzymatic Conversion of Cellulosic Materials into Glucose. In: BIOGAS-85.
PROBLEMS AND SOLUTIONS. MOSCOW-HELSINKI, 237-259, 1985.
306.
Gusakov, A.V., Sinitsyn, A.P., Klyosov, A.A. Kinetics of the Enzymatic Hydrolysis
of Cellulose: 1. A Mathematical Model for a Batch Reactor Process. ENZYME
MICROB. TECHNOL., 7, 346-352, 1985.
307.
Gusakov, A.V., Sinitsyn, A.P., Klyosov, A.A. Kinetics of the Enzymatic Hydrolysis
of Cellulose: 2. A Mathematical Model for the Process in a Plug-Flow Column Reactor.
ENZYME MICROB. TECHNOL., 7, 383-388, 1985.
308.
Klyosov, A.A., Bolobova, A.V., Ostrovskaya, M.V., Poglazov, B.F. The Activation
26
of Cellulases from Different Sources by Actin. FEBS LETTERS, 187, 101-104, 1985.
309.
Klyosov, A.A. Computer Conferences on the Agenda. SCIENCE IN THE USSR,
No.6, 85-89, 1985.
310.
Klyosov, A.A. The Biotechnology of the Enzymatic Conversion of Cellulosic
Materials to Sugars and Alcohol. In: ENERGY SAVING IN INDUSTRY, AGRICULTURE
AND BIOMASS. REGGIO EMILIA, ITALY, 1-27, 1986.
311.
Rabinovich, M.L., Klyosov, A.A., Melnick, M.S. The Titration of the Active Centres
of Cellobiohydrolase from Trichoderma reesei. ANAL. BIOCHEM., 156, 489-494, 1986.
312.
Klyosov, A.A., Mitkevich, O.V., Sinitsyn, A.P. Role of the Activity and Adsorption
of Cellulases in the Efficiency of the Enzymatic Hydrolysis of Amorphous and Crystalline
Cellulose. BIOCHEMISTRY, 25, 540-542, 1986.
313.
Klyosov, A.A. Cellulases of the Third Generation. In: SOVIET-FINNISH SEMINAR
ON MICROBIAL DEGRADATION OF LIGNOCELLULOSE RAW MATERIALS.
PUSHCHINO, 56-65, 1986.
314.
Gusakov, A.V., Sinitsyn, A.P., Klyosov, A.A. Factors Affecting the Enzymatic
Hydrolysis of Cellulose in Batch and Continuous Reactors: Computer Simulation and
Experiment. BIOTECHNOL. BIOENG., 29, 906-910, 1987.
315.
Gusakov, A.V., Sinitsyn, A.P., Klyosov, A.A. A Theoretical Comparison of the
Reactors for the Enzymatic Hydrolysis of Cellulose. BIOTECHNOL. BIOENG., 29, 898900, 1987.
316.
Kovalev, G.V., Sinitsyn, A.P., Volf, E.G., Kalyazin, E.P., Bugaenko, L.T., Klyosov,
A.A. Enzymatic Conversion of Irradiated Cellulosis Materials. BRITISH POLYMER J., 19,
63-66, 1987.
317.
Rodriguez, H., Volfova, O., Klyosov, A.A. Characterization of the Cellulase
Complex from Cellulomonas Grown on Bagasse Pith. APPL. MICROBIOL.
BIOTECHNOL., 28, 394-397, 1988.
318.
Klyosov, A.A. Cellulases of the Third Generation. In: BIOCHEMISTRY AND
GENETICS OF CELLULOSE DEGRADATION. Academic Press, London, 87-99, 1988.
319.
Klyosov, A.A., Ermolova, O.V., Chernoglazov, V.M. A Thermostable Endo-1,4-betaGlucanase from Myceliophthora thermophila. BIOTECHNOL. LETTERS, 10, 351- 354,
1988.
320.
Chernoglazov, V.M., Ermolova, O.V., Klyosov, A.A. Adsorption of High-Purity
27
Endo-1,4-beta-Glucanases from Trichoderma reesei on Components of Lignocellulosic
Materials: Cellulose, Lignin, and Xylan. ENZYME MICROB. TECHNOL., 10, 503- 507,
1988.
321.
Sinitsyn, A.P., Mitkevich, O.V., Gusakov, A.V., Klyosov, A.A. Decrease in
Reactivity and Change of Physicochemical Parameters of Cellulose in the Course of
Enzymatic Hydrolysis. CARBOHYDRATE POLYMERS, 10, 1-14, 1989.
322.
Chernoglazov, V.M., Ermolova, O.V., Vozny, Y.V., Klyosov, A.A. A Method for
Detection of Cellulases in Polyacrylamide Gels Using 5-Bromoindoxyl-beta-DCellobioside: High Sensitivity and Resolution. ANAL. BIOCHEM., 182, 250-253, 1989.
323.
Chernoglazov, V.M., Jafarova, A.N., Klyosov, A.A. Continuous Photometric
Determination of Endo-1,4-Beta-D-Glucanase (Cellulase) Activity Using 4Methylumbelliferyl-Beta-D-Cellobioside as a Substrate. ANAL. BIOCHEM., 179, 186- 189,
1989.
324.
Lapidus, A.L., Mochulskii, A.V., Podkovyrov, S.M., Lebedeva, M.I., Antipin, A.A.,
Izotova, L.S., Zagnitko, O.P., Komolova, G.S., Klyosov, A.A., Veiko, V.P., Mashko, S.V.
Expression of the hAng Gene in Escherichia coli; Isolation and Characterization of Human
Recombinant Ser-(-1) Angiogenin. BIOMEDICAL SCIENCE, 1, 597-604, 1990.
325.
Rashkovetsky, L.G., Maret, W., Klyosov, A.A. Human Liver Aldehyde
Dehydrogenases: New Method of Purification of the Major Mitochondrial and Cytosolic
Enzymes and Re-Evaluation of Their Kinetic Properties. BIOCHIM. BIOPHYS. ACTA,
1205, 301- 307, 1994.
326.
Bolobova, A.V., Zhukov, A.V., Klyosov, A.A. Lipids and Fatty Acids in
Cellulosomes of Clostridium thermocellum. APPLIED MICROBIOL. BIOTECHNOL, 42,
128-133, 1994.
327.
Klyosov, A.A., Rashkovetsky, L.G., Tahir, M.K., W.-M. Keung. Possible Role of
Liver Cytosolic and Mitochondrial Aldehyde Dehydrogenases in Acetaldehyde Metabolism.
BIOCHEMISTRY, 35, 4445-4456, 1996.
328.
Klyosov, A.A. Kinetics and Specificity of Human Liver Aldehyde Dehydrogenases
Toward Aliphatic, Aromatic, and Fused Polycyclic Aldehydes. BIOCHEMISTRY, 35, 44574467, 1996.
329.
Keung, W.-M., Klyosov, A.A., Vallee B.L. Daidzin Inhibits Mitochondrial Aldehyde
Dehydrogenase and Suppresses ethanol Intake of Syrian Golden Hamsters. Proc. Natl. Acad.
Sci. USA, 94, 1675-1679, 1997.
330.
Hjelmqvist, L., Lundgren, R., Norin, A., Jornvall, H., Vallee, B., Klyosov, A.A.,
28
Keung, W.M. Class 2 Aldehyde Dehydrogenase. Characterization of the Hamster Enzyme,
Sensitive to Daidzin and Conserved Within the Family of Multiple Forms. FEBS
LETTERS, 416 (1), 99-102, 1997.
331.
Olsufyeva, E.N., Tevyashova, A.N., Trestchalin, I.D., Preobrazhenskaya, M.N.,
Platt, D., Klyosov, A.A. Synthesis and Antitumor Activity of New Galactose-Containing
Derivatives of Doxorubicin. Carbohydrate Research, 338 (13), 1359-1367, 2003.
332.
Klyosov, A.A., Platt, D., Zomer, E. Preclinical Studies of Anticancer Efficacy of
5-Fluorouracil when Co-Administered with the 1,4-beta-D-Galactomannan.
PRECLINICA, 1, 175-186, 2003.
333.
Tevyashova, A.N., Olsufyeva, E.N., Preobrazhenskaya, M.N., Klyosov, A.A.,
Zomer, E., Platt, D. New Conjugates of an Antitumor Antibiotics Doxorubicin with a
Water-soluble Galactomannan: Synthesis and Biological Activity. Bioorganic Chemistry
(Moscow, in Russian), v. 33, No. 1, pp. 1 – 8, 2007.
334.
Zalupski, M., Fuloria, J., Perez, R., Abubaker, Y., Nahum, K.D., Platt, D.,
Klyosov, A.A., Zomer, E. Pharmacokinetic Translationals Study in Advanced Solid
Tumors of 5-FU with an Admixture of a Galactomannan Derivative. Cancer Research,
Tumor Markers, Clinical Oncology, P6_4, p. 119, 2007.
335.
Miller, M., Klyosov, A.A., Platt, D., Mayo, K. Using Pulse Field Gradient NMR
Diffusion Measurements to Define Molecular Weight Distributions in Glycan
Preparations. Carbohydrate Research, 344, 1205-1212, 2009.
336.
Miller, M., Nesmelova, I.V., Platt, D., Klyosov, A.A., Mayo, K. The
Carbohydrate-Binding Domain on Galectin-1 is more extensive for a complex glycan
than for simple saccharides: implications for galectin-glycan interactions at the cell
surface. Biochem. J., 421, 211-221, 2009.
337.
Miller, M.C., Klyosov, A. Mayo, K.H. The α-Galactomannan Davanat binds
galectin-1 at a site different from the conventional galectin carbohydrate binding domain.
Glycobiology, 19, 1034-1045, 2009.
338.
Miller, M.C., Ribeiro, J.P., Roldos, V., Martin-Santamaria, S., Canada, F.J.,
Nesmelova, I., Andre, S., Pang, M., Klyosov, A., Baum, L.G., Jimenez-Barbero, J.,
Gabius, H.-J., Mayo, K.H. Structural aspects of binding of alpha-linked digalactosides to
human galectin-1. Glycobiology, 21, 1627-1641, 2011.
339.
Miller, M.C., Klyosov, A.A., Mayo, K. H. Structural features for αgalactomannan binding to galectin-1. Glycobiology, 22, 543-551, 2012.
29
340.
Klyosov, A.A., Dotsenko, G.S., Hinz, S.W., Sinitsyn, A.P. Structural features of
beta-(1-->4)-D-galactomannans of plant origin as a probe for beta-(1-->4)-mannanase
polymer substrate specificity. Carbohydrate Research, 352, 65-69, 2012.
Papers in DNA Genealogy
341.
Klyosov, A.A. DNA Genealogy, mutation rates, and some historical evidences
written in Y-chromosome. I. Basic principles and the method. J. Genetic Genealogy, 5, 186216, 2009.
342.
Klyosov, A.A. DNA Genealogy, mutation rates, and some historical evidences
written in Y-chromosome. II. Walking the map. J. Genetic Genealogy, 5, 217-256, 2009.
343.
Klyosov, A.A. A comment on the paper: Extended Y chromosome haplotypes
resolve multiple and unique lineages of the Jewish Priesthood. Human Genetics, 126, 719724, 2009.
344.
Klyosov, A.A. Biological chemistry as a foundation of DNA genealogy: the
emergence of “Molecular History”. Biochemistry (Springer) vol. 76, No. 5, 517-533,
Pleiades Publishing, 2011.
345.
Rozhanskii, I.L., Klyosov, A.A. Mutation rate constants in DNA genealogy (Y
chromosome). Advances in Anthropology, 1, No. 2, 26-34, 2011
346.
Klyosov, A.A., Rozhanskii, I.L. Haplogroup R1a as the Proto Indo-Europeans and the
legendary Aryans as witnessed by the DNA of their current descendants. Advances in
Anthropology, 2, No. 1, 1-13, 2012
347.
Klyosov, A.A., Rozhanskii, I.L. Re-examining the “Out of Africa” theory and the
origin of Europeoids (Caucasoids) in light of DNA genealogy. Advances in Anthropology, 2,
No. 2, 80-86, 2012
348.
Klyosov, A.A. Ancient history of the Arbins, bearers of haplogroup R1b, from
Central Asia to Europe, 16,000 to 1500 years before present. Advances in Anthropology, 2,
No. 2, 87-105, 2012
349.
Rozhanskii, I.L., Klyosov, A.A. Haplogroup R1a, its subclades and branches in
Europe during the last 9,000 years. Advances in Anthropology, 2, No. 3, 139-156, 2012
350.
Klyosov, A.A., Rozhanskii, I.L., Ryanbchenko, L.E. Re-examining the Out-of- Africa
theory and the origin of Europeoids (Caucasoids). Part 2. SNPs, haplogroups and haplotypes
30
in the Y charomosome of Chimpanzee and Humans. Advances in Anthropology, 2, No. 4,
198-213, 2012
351.
Klyosov, A.A., Tomezzoli, G.T. DNA genealogy and linguistics. Ancient Europe.
Advances in Anthropology, 3, No. 2, 101-111.
352.
Klyosov, A.A. Basic rules of DNA genealogy (Y-chromosome). Mutation rates
and their calibration. Proceedings of the Russian Academy of DNA Genealogy (ISSN
1942-7484), 1, 3-53, 2008.
353.
Klyosov, A.A. Origin of the Jews via DNA genealogy. Proceedings of the Russian
Academy of DNA Genealogy, 1, 54-232, 2008.
354.
Klyosov, A.A. A comment on the Paper: A Western Eurasian Male Is Found in
2000-Year-Old Elite Xiongnu Cemetery in Northeast Mongolia, by K. Kim, C.H.
Brenner, V. H. Mair et al. Amer. J. Phys. Anthrop., Published online, DOI
10.1002/ajpa.21242, 2010. Proceedings of the Russian Academy of DNA Genealogy, vol.
3, No. 4, 623-634, 2010.
355.
Klyosov, A.A. Origin of the Jews and the Arabs: Date of their Most Recent
Common Ancestor is Written in Their Y Chromosomes – However, There Were Two of
Them. Proceedings of the Russian Academy of DNA Genealogy, vol. 3, No. 4, 635-653,
2010.
356.
Klyosov, A.A. Irish haplotypes and haplogroups. Proc. Russian Academy of DNA
Genealogy, 3, No. 6, 1029-1053, 2010.
357.
Klyosov, A.A. DNA-lineages and origin of the “Tenths”, the North-Western
European subfamily R1a1 with DYS388=10. Proc. Russian Academy of DNA Genealogy, 3,
No. 6, 983-1028, 2010.
358.
Klyosov, A.A. Subclade R1b1b2-L226 (“Irish III”) – the latest update. Proc. Russian
Academy of DNA Genealogy, 3, No. 7, 1211-1213, 2010.
359.
MacEacharn, A., Klyosov, A.A. Scotland’s R1a1 Highland Clansmen, DNA
Genealogy and the search for Somerled. Proc. Russian Academy of DNA Genealogy, 3, No.
8, 1325-1358, 2010.
360.
Klyosov, A.A. DNA-lineages and origin of the Tenths, the R1a1 subfamily with
DYS388=10: the story in progress. Proc. Russian Academy of DNA Genealogy, 3, No.
12, 2205-2217, 2010.
361.
Klyosov, A.A. Haplotypes of R1b1a2-P312 and related subclades: origin and
“ages” of most recent common ancestors. Proceedings of the Russian Academy of DNA
31
Genealogy, vol. 4, No. 6, 1127-1195, 2011
362.
Klyosov, A.A. MacDonalds and Scottish R1b1a2 Haplotypes. Proceedings of the
Russian Academy of DNA Genealogy, vol. 4, No. 6, 1196-1229, 2011.
363.
Klyosov, A.A. MacDonalds and Scottish Haplotypes of Haplogroup I.
Proceedings of the Russian Academy of DNA Genealogy, vol. 4, No. 6, 1230-1238, 2011.
364.
Klyosov, A.A. The slowest 22 marker haplotype panel (out of the 67 marker
panel) and their mutation rate constants employed for calculations timespans to the most
ancient common ancestors. Proceedings of the Russian Academy of DNA Genealogy,
vol. 4, No. 6, 1239-1256, 2011.
365.
Klyosov, A.A. DNA genealogy of the major haplogroups of Y chromosome (Part
1) Proceedings of the Russian Academy of DNA Genealogy, vol. 4, No. 6, 1257-1282,
2011.
366.
Klyosov, A.A. “Service by Blood and Death”. Klyosov (R1a1, West-Eurasian
branch) Family Story as a Mirror of Russian History. Proceedings of the Russian
Academy of DNA Genealogy, vol. 4, No. 6, 1283-1305, 2011.
367.
Klyosov, A.A. The mutation rate constant for the 111 marker haplotype panel.
Proc. Russian Academy of DNA Genealogy, 4, No. 7, 1535-1539, 2011.
368.
Klyosov, A.A. This is the Man. The DNA genealogy based on Y chromosome.
Proceedings of the Russian Academy of DNA Genealogy (ISSN 1942-7484), vol. 1, No.
2, 237-251, 2008.
369.
Klyosov, A.A. Basic rules of DNA genealogy. Proceedings of the Russian
Academy of DNA Genealogy, 1, No. 2, 252-348, 2008.
370.
Klyosov, A.A. Where Slavs and Indo-Europeans came from? Proc. Russian Academy
of DNA Genealogy, 1, 400-477, 2008.
371.
Klyosov, A.A. This is the Woman. The DNA genealogy based on mitochondrial
DNA. Proceedings of the Russian Academy of DNA Genealogy, vol. 1, No. 2, 478-489,
2008.
372.
Klyosov, A.A. Mysteries of the “Western European” haplogroup R1b. Proc. Russian
Academy of DNA Genealogy, 1, № 4, 568-629, 2008.
373.
Adamov, D.S., and Klyosov, A.A. Theoretical and practical estimates of reverse
mutations in haplotypes of Y chromosome (in Russian). Proc. Russian Academy of DNA
Genealogy, 1, 631-645, 2008.
32
374.
Klyosov, A.A. Calculations of time spans to common ancestors for haplotypes of Y
chromosome and the table for reverse mutations. Proc. Russian Academy of DNA
Genealogy, 1, № 5, 812-835, 2008.
375.
Adamov, D.S., and Klyosov, A.A. Evaluation of an “age” of populations from Y
chromosome using methods of average square distance (in Russian). Proc. Russian Academy
of DNA Genealogy, 1, 855-905, 2008.
376.
Klyosov, A.A. The ancient Aryans: who were they and where they came from? Proc.
Russian Academy of DNA Genealogy, 1, № 5, 908-928, 2008.
377.
Klyosov, A.A. Haplotypes of haplogroup R1a1 in the post-Soviet region. Proc.
Russian Academy of DNA Genealogy, 1, 947-957, 2008.
378.
Klyosov, A.A. Szeklers of Eastern Europe and their haplogroups and haplotypes.
Proc. Russian Academy of DNA Genealogy, 2, № 1, 2-51, 2009.
379.
Klyosov, A.A. A discussion of a Northern route of Y chromosomes of haplogroup N
from South East Asia to Europe. Proc. Russian Academy of DNA Genealogy, 2, № 1, 568629, 2008.
380.
Klyosov, A.A. A discussion of the origin of Gagauzes of South Eastern Europe. Proc.
Russian Academy of DNA Genealogy, 2, № 1, 69-80, 2009.
381.
Adamov, D.S., and Klyosov, A.A. Evaluation of an “age” of populations from Y
chromosome. Part I. Theory. Proc. Russian Academy of DNA Genealogy, 2, 81-92, 2009.
382.
Adamov, D.S., and Klyosov, A.A. Evaluation of an “age” of populations from Y
chromosome. Part II. Statistical considerations. Proc. Russian Academy of DNA Genealogy,
2, 93-103, 2009.
383.
Adamov, D.S., and Klyosov, A.A. Evaluation of an “age” of populations from Y
chromosome. Part III. Examples of the “linear” and “quadratic” models with different degree
of the asymmetry of mutations. Proc. Russian Academy of DNA Genealogy, 2, 187-199,
2009.
384.
Klyosov, A.A. Haplotypes of Eastern Slavs: nine tribes? Proc. Russian Academy of
DNA Genealogy, 2, 232-251, 2009.
385.
Klyosov, A.A. Haplotypes of Finno-Ugric Northern Slavs: seven tribes? Proc.
Russian Academy of DNA Genealogy, 2, 370-389, 2009.
386.
Klyosov, A.A. Iberian haplotypes, and analysis of history of populations of Basques,
33
Sephardim and other groups in the Iberian peninsula. Proc. Russian Academy of DNA
Genealogy, 2, 390-421, 2009.
387.
Adamov, D.S., and Klyosov, A.A. Practical methods for determining “age” of
common ancestors for large haplotype series. Proc. Russian Academy of DNA Genealogy, 2,
422-442, 2009.
388.
Klyosov, A.A. Critical comments to the paper by Sharma et al in Human Genetics
(January 2009) on “the Indian origin of haplogroup R1a1”. Proc. Russian Academy of DNA
Genealogy, 2, 443-451, 2009.
389.
Klyosov, A.A. “To die for a princess”: an investigation in DNA genealogy. Proc.
Russian Academy of DNA Genealogy, 2, 452-481, 2009.
390.
Lutak, S.V., Klyosov, A.A. Haplogroup E1b1b1a-M78 as descendants of ancient
Egyptians. Proc. Russian Academy of DNA Genealogy, 2, 639-669, 2009.
391.
Klyosov, A.A. Haplotypes of Southern and Baltic Russian Slavs: four tribes? Proc.
Russian Academy of DNA Genealogy, 2, 801-815, 2009.
392.
Klyosov, A.A. DNA genealogy and linguistics. Proc. Russian Academy of DNA
Genealogy, 2, 821-941, 2009.
393.
Klyosov, A.A. Haplogroup J2 in India and Russia. An “age” of ancestors. Proc.
Russian Academy of DNA Genealogy, 2, 842-854, 2009.
394.
Klyosov, A.A. On an incorrect assignment of the Siberian R1a1 haplotypes to the
Kurgan archaeological culture (discussion of the paper by Keyser et al in Human Genetics,
2009). Proc. Russian Academy of DNA Genealogy, 2, 871-878, 2009.
395.
Klyosov, A.A. The most ancient Eastern Asian branches of haplogroup R1a1. Proc.
Russian Academy of DNA Genealogy, 2, 879-890, 2009.
396.
Klyosov, A.A. Calculations of the “age” of common ancestors of haplogroup R2 in
India. Proc. Russian Academy of DNA Genealogy, 2, 891-895, 2009.
397.
Klyosov, A.A. Haplotypes of the “African” haplogroup A. Proc. Russian Academy of
DNA Genealogy, 2, 896-899, 2009.
398.
Klyosov, A.A. Haplotypes of the “African” haplogroup B. Proc. Russian Academy of
DNA Genealogy, 2, 900-901, 2009.
399.
Rozhanskii, I.L., Klyosov, A.A. HaplogroupR1a1: haplotypes, lineages, history,
geography. Proc. Russian Academy of DNA Genealogy, 2, 974-1099, 2009.
34
400.
Klyosov, A.A. On “multiple and unique lineages” of the Cohens (an alternative
analysis of the data presented in the publication by Hammer, Behar, Karafet, Mendez,
Hallmark, Erez, Zhivotovsky et al in Human Genetics, August 2009. Proc. Russian Academy
of DNA Genealogy, 2, 1100-1116, 2009.
401.
Aliev, A.A., Ampilogov, A.Yu., Lutak, S.V., Klyosov, A.A. A pattern of the ancient
Hanaan in the DNA of present-day Jews. Proc. Russian Academy of DNA Genealogy, 2,
1117-1124, 2009.
402.
Klyosov, A.A. Once again on the “population mutation rate” by L. Zhivotovsky. An
extended comment on “Response” by M. Hammer et al in Human Genetics, October 8, 2009.
Proc. Russian Academy of DNA Genealogy, 2, 1162-1181, 2009.
403.
Klyosov, A.A., Luguev, R.G. Did Seyids originate from the DNA lineage of
Mohammed the Prophet, and the Prophet, as well as the Jews, from Abraham? Proc. Russian
Academy of DNA Genealogy, 2, 1182-1199, 2009.
404.
Klyosov, A.A., Rozhanskii, I.L. Subclade R1a1a7-M458: its population, geography,
history. Proc. Russian Academy of DNA Genealogy, 2, 1200-1216, 2009.
405.
Klyosov, A.A. An one more evidence for the migration of the Aryans (haplogroup
R1a1) to India and Iran from the Russian Plain. Proc. Russian Academy of DNA Genealogy,
2, 1217-1229, 2009.
406.
Klyosov, A.A. The terminology and definitions in DNA genealogy. Proc. Russian
Academy of DNA Genealogy, 2, 1257-1263, 2009.
407.
Klyosov, A.A. The general principles of DNA genealogy: the New Edition. Proc.
Russian Academy of DNA Genealogy, 2, 1264-1330, 2009.
408.
Klyosov, A.A. A mystery in relationships between the Indo-European and Turkic
language families and an attempt to solve it with the help of DNA genealogy. Proc. Russian
Academy of DNA Genealogy, 3, No.1, 2-57, 2010.
409.
Rozhanskii, I.L., Klyosov, A.A. Migrations from South Siberia and Central Asia to
Northern Europe from the viewpoint of DNA genealogy. Proc. Russian Academy of DNA
Genealogy, 3, No.1, 66-77, 2010.
410.
Klyosov, A.A. Haplogroup I. Proc. Russian Academy of DNA Genealogy, 3, No.1,
96-158, 2010.
411.
Klyosov, A.A. Which haplogroup should have Abraham belonged to – J1 or J2? Proc.
Russian Academy of DNA Genealogy, 3, No.2, 168-186, 2010.
35
412.
Klyosov, A.A. Again on reading of ancient Etruscan scripts, or “Hetruscum non
ligatur”. Proc. Russian Academy of DNA Genealogy, 3, No.2, 187-190, 2010.
413.
Klyosov, A.A. Mapping of Europe by R1b1b2-L21 migration times. Proc. Russian
Academy of DNA Genealogy, 3, No.2, 191-201, 2010
414.
Klyosov, A.A. Haplogroup R1b. Part 1. Proc. Russian Academy of DNA Genealogy,
3, No.2, 249-299, 2010.
415.
Klyosov, A.A. Haplotypes of the R1b haplogroup in Central Africa. Proc. Russian
Academy of DNA Genealogy, 3, No. 3, 369-378, 2010.
416.
Aliev, A.A., Klyosov A.A. Part of “Mountain Jews” are descendants of Abraham on
their male lineage. Proc. Russian Academy of DNA Genealogy, 3, No. 3, 379-384, 2010.
417.
Klyosov, A.A. The first example of determining of a timespan to a common ancestor
from excavated haplotypes. Proc. Russian Academy of DNA Genealogy, 3, No. 3, 385-390,
2010.
418.
Klyosov, A.A. A consideration of a family of (L21+M222-) haplotypes with the “1113 signature”. Proc. Russian Academy of DNA Genealogy, 3, No. 3, 391-397, 2010.
419.
Klyosov, A.A. (2010) Consideration of 37 Irish R1a1 haplotypes and 1036 R1b1
haplotypes in the same series of 67 marker haplotypes: a separation of the R1a1 subclade of
the Russian Plain and R-M222, and timespans to their common ancestors. Proc. Russian
Academy of DNA Genealogy, 3, No. 3, 398-405, 2010.
420.
Klyosov, A.A. (2010) Haplogroup R1b. Part 2. Proc. Russian Academy of DNA
Genealogy, 3, № 3, 406-475, 2010.
421.
Klyosov, A.A. A critical analysis of a review to the journal “Problems of
Linguistics”. Proc. Russian Academy of DNA Genealogy, 3, № 4, 533-544, 2010.
422.
Klyosov, A.A. Comments on the paper “Y-haplogroups of bearers of the Aryan
language” by A.A. Aliev and Smirnov A.S. Proc. Russian Academy of DNA Genealogy, 3,
№ 4, 595-599, 2010
423.
Klyosov, A.A. On mutation rates in haplotypes in a one generation, in farther-son
pairs. Proc. Russian Academy of DNA Genealogy, 3, № 4, 600-603, 2010
424.
Klyosov, A.A. Migration route of R1b1b2 to Europe (1). A critical consideration of
the P. Balaresque et al (PLoS Biology) paper. Proc. Russian Academy of DNA Genealogy,
3, No. 6, 896-902, 2010.
36
425.
Klyosov, A.A. Migration route of R1b1b2 to Europe (2). A critical consideration of
the L. Morelli et al (PLoS ONE) paper. Proc. Russian Academy of DNA Genealogy, 3, No.
6, 903-915, 2010.
426.
Klyosov, A.A. Comments on a paper by A. Shtrunov “The origin of I1-M253
haplogroup in Eastern Europe. Proc. Russian Academy of DNA Genealogy, 3, No. 6, 916920, 2010.
427.
Klyosov, A.A. Ancient, “non-Indo-European” haplotypes of R1a1 haplogroup in
North-Western China. Proc. Russian Academy of DNA Genealogy, 3, No. 6, 925-942, 2010.
428.
Klyosov, A.A. The Neanderthals. Proc. Russian Academy of DNA Genealogy, 3, No.
6, 942-968, 2010.
429.
Klyosov, A.A. Subclade R1b1b2-M153 on the Iberian Peninsula and among the
Basques. Proc. Russian Academy of DNA Genealogy, 3, No. 6, 976-982, 2010.
430.
Klyosov, A.A. The genome-wide analysis of Jewish populations and its comparison
with data of DNA genealogy. Proc. Russian Academy of DNA Genealogy, 3, No. 7, 11441164, 2010.
431.
Klyosov, A.A. Haplotypes of P312* subclade: a history in letters. Proc. Russian
Academy of DNA Genealogy, 3, No. 7, 1165-1183, 2010.
432.
433.
Klyosov, A.A. DNA genealogy, craniometry and the origin of the Europeoids.
Proc. Russian Academy of DNA Genealogy, 3, No. 8, 1256-1309, 2010.
434.
Klyosov, A.A. An “age” of R1b1b2-M269 subclade and its downstream subclades
L23, L51, L11. Proc. Russian Academy of DNA Genealogy, 3, No. 8, 1310-1315, 2010.
435.
Klyosov, A.A. A “diversity” of the tetra-loci microsatellite DYS464 of Y
chromosome. Proc. Russian Academy of DNA Genealogy, 3, No. 9, 1407-1412, 2010.
436.
Klyosov, A.A. Migration route of R1b haplogroup to Europe and its populating in
Europe. A critical analysis of Myres et al paper “A Major Y-chromosome haplogroup
R1b…” (Eur. J. Hum. Genetics, 26 August 2010). Proc. Russian Academy of DNA
Genealogy, 3, No.10, 1652-1675, 2010.
437.
Klyosov, A.A. Haplogroup R1b1 and its subclades in Asia. Proc. Russian Academy
of DNA Genealogy, 3, No.10, 1676-1695, 2010.
438.
Klyosov, A.A. Hypothesis on origin of the Turks, Sino-Caucasian (proto-Turkic?)
languages, and haplogroup R1b. Proc. Russian Academy of DNA Genealogy, 3, No.10,
37
1757-1764, 2010.
439.
Klyosov, A.A. On “age” of haplogroup R1b1b2 in the Caucasus. Proc. Russian
Academy of DNA Genealogy, 3, No.10, 1801-1802, 2010.
440.
Klyosov, A.A. Mutations in haplotypes of Y chromosome of father-son pairs and
their significance for DNA genealogy. Proc. Russian Academy of DNA Genealogy, 3, No.11,
1853-1860, 2010.
441.
Klyosov, A.A. Once more on mutation rate constants in haplotypes of Y
chromosome. Critical comments on a paper “Mutation rate estimates for 110 Ychromosome STRs combining population and father-son pair data” by C. Burgarella and
M. Navascues, Eur. J. Hum. Genet., 8 September 2010. Proc. Russian Academy of DNA
Genealogy, 3, No.11, 1861-1865, 2010.
442.
Klyosov, A.A. Haplogroup R1a1 and its subclades in Asia. Proc. Russian Academy
of DNA Genealogy, 3, No.11, 1866-1896, 2010.
443.
Klyosov, A.A. DNA genealogy against the “Norman theory” of non-Slavic origin of
the rulers of the ancient Russian state. Proc. Russian Academy of DNA Genealogy, 3, No.11,
1966-1970, 2010.
444.
Klyosov, A.A., Rozhanskii, I.L. A reconsideration of the mutation rate constant for
the 67 marker haplotypes – from 0.145 to 0.120 mutations per haplotype per generation.
Proc. Russian Academy of DNA Genealogy, 3, No.12, 2039-2058, 2010.
445.
Klyosov, A.A. On a rare type of mutations in DYS390 in haplogroup Rb1b1. Proc.
Russian Academy of DNA Genealogy, 3, No.12, 2059-2064, 2010.
446.
Klyosov, A.A. Excavated haplotypes of the linear band ceramics archaeological
culture (comments on a recent publication by Haak et al, 2010). Proc. Russian Academy of
DNA Genealogy, 3, No.12, 2065-2069, 2010.
447.
Klyosov, A.A. Haplogroup O and its subclades in Asia. Proc. Russian Academy of
DNA Genealogy, 3, No.12, 2070-2083, 2010.
448.
Klyosov, A.A. On time and place of origin of R1b haplogroup (reading Wikipedia
with disbelief and astonishment). Proc. Russian Academy of DNA Genealogy, 3, No.12,
2084-2109, 2010.
449.
Klyosov, A.A. History of R1a and R1b haplogroups in Iran and Lebanon. Proc.
Russian Academy of DNA Genealogy, 4, No.1, 20-32, 2011.
38
450.
Klyosov, A.A. Haplogroup R1a on Comoros Islands and ancient migrations of R1a1
and R1b haplogroups. Proc. Russian Academy of DNA Genealogy, 4, No.1, 33-39, 2011.
451.
Klyosov, A.A. Reading “Ancient Migrations and the Origin of IndoEuropean
Peoples” by L.S. Klein. Proc. Russian Academy of DNA Genealogy, 4, No.1, 40-65, 2011.
452.
Klyosov, A.A. New evidences for the migration of the Aryans from the Russian Plain
to India: the analysis of the tetra-loci microsatellite DYS464 of Y chromosome. Proc.
Russian Academy of DNA Genealogy, 4, No. 2, 215-245, 2011.
453.
Klyosov, A.A. DNA genealogy of the contemporary “Great Count of the Whole
Russia”. An investigation into the false claims. Proc. Russian Academy of DNA Genealogy,
4, No. 2, 403-418, 2011.
454.
Klyosov, A.A. On the DNA methodology to the search of the lost expedition of
Alexander the Great. Proc. Russian Academy of DNA Genealogy, 4, No. 3, 502-537, 2011.
455.
Klyosov, A.A. Subclades J2a4b and J2a4b1: a spread, age, the ancestral haplotypes.
Proc. Russian Academy of DNA Genealogy, 4, No. 3, 583-590, 2011.
456.
Klyosov, A.A. On the relationships between DNA genealogy, genetics and population
genetics. Proc. Russian Academy of DNA Genealogy, 4, No. 3, 709-714, 2011.
457.
Klyosov, A.A. Sumers as the ancient bearers of R1b1b2 haplogroup? Proc. Russian
Academy of DNA Genealogy, 4, No.4, 762-763, 2011.
458.
Klyosov, A.A. A critical consideration of the paper “Decreased rate of evolution in Y
Chromosome STR loci of increased size of the repeat unit” (by M. Jarve, L. Zhivotovsky et
al), PLOS One, v. 4, e7276, doi:10.1371). Proc. Russian Academy of DNA Genealogy, 4,
No.5, 960-967, 2011.
459.
Klyosov, A.A. Calculations of the mutation rate constants for the slowest 22
marker haplotype panel. Proceedings of the Russian Academy of DNA Genealogy, vol. 4,
No. 5, 968-987, 2011.
460.
Klyosov, A.A. DNA genealogy of the major haplogroups of Y chromosome of the
mankind (Part 1). Proceedings of the Russian Academy of DNA Genealogy, vol. 4, No. 5,
988-1014, 2011.
461.
Klyosov, A.A. DNA genealogy of the major haplogroups of Y chromosome of the
mankind (Part 2). Proceedings of the Russian Academy of DNA Genealogy, vol. 4, No. 7,
1367-1494, 2011.
462.
Klyosov, A.A., Rozhanskii, I.L. The archaic (archanthropic in terms of
39
anthropology) lineage of haplogroup A. Proceedings of the Russian Academy of DNA
Genealogy, vol. 4, No. 7, 1495-1502, 2011.
463.
Klyosov, A.A. The origin of Jews in the context of DNA genealogy. Proceedings
of the Russian Academy of DNA Genealogy, vol. 4, No. 7, 1503-1514, 2011.
464.
Klyosov, A.A. The present status of DNA genealogy: subject, methodology,
illustrations. Современные представления о ДНК-генеалогии: предмет, методология,
иллюстрации. Proceedings of the Russian Academy of DNA Genealogy, vol. 4, No. 8,
1548-1579, 2011.
465.
Klyosov, A.A. Laks and Akkads of the ancient Sumer. Proceedings of the Russian
Academy of DNA Genealogy, vol. 4, No. 8, 1580-1583, 2011.
466.
Klyosov, A.A. Finno-Ugric and South-Baltic branches of haplogroup N1c1 and
their haplotypes. Proceedings of the Russian Academy of DNA Genealogy, vol. 4, No. 8,
1604-1626, 2011.
467.
Klyosov, A.A. The Belgian DNA Project “The Old Duchy of Brabant” and its
results. Proceedings of the Russian Academy of DNA Genealogy, vol. 4, No. 8, 16271632, 2011.
468.
Klyosov, A.A. Once more on the DNA genealogy of Russian Princes of N1c1
haplogroup and their “follow travelers”. Proceedings of the Russian Academy of DNA
Genealogy, vol. 4, No. 9, 1709-1715, 2011.
469. Klyosov, A.A. Haplogroup R1b as a carrier of Proto-Türkic languages, aka DeneCaucasian languages, aka Erbin, that is a non-IndoEuropean language in its dynamics
during 16,000 to 3,000 years before present. Proceedings of the Russian Academy of
DNA Genealogy, vol. 4, No. 9, 1716-1773, 2011
470.
Rozhanskii, I.L., Klyosov, A.A. A contemporary status of subclades and branches
of haplogroup R1a1a1. Proceedings of the Russian Academy of DNA Genealogy, vol. 4,
No. 9, 1774-1775, 2011
471.
Klyosov, A.A. The «Out of Africa» theory – genetics and DNA genealogy are in
disagreement. Proceedings of the Russian Academy of DNA Genealogy, vol. 4, No. 10,
1908-1977, 2011
472.
Palindromic mutations of quadruples DYS464 in the V13 subclade of haplogroup
E and a calculation of the timespan to a common ancestor of the subclade using presentday haplotypes. Proceedings of the Russian Academy of DNA Genealogy, vol. 4, No. 10,
1978-1984, 2011
40
473.
Klyosov, A.A. Haplogroups and haplotypes of Armenia (haplogroups J2, R1bL23, R1b-M269 и T-M184). Proceedings of the Russian Academy of DNA Genealogy,
vol. 4, No. 10, 1985-1993, 2011
474.
Klyosov, A.A. The haplotype of Pharaoh Tutankhamon (1333 – 1323 BC) and its
possible origin. Proceedings of the Russian Academy of DNA Genealogy, vol. 4, No. 11,
2063-2069, 2011
475.
Klyosov, A.A. Haplotypes of haplogroups R1a1 and N1 in the Eastern Himalayas.
Proceedings of the Russian Academy of DNA Genealogy, vol. 4, No. 11, 2070-2072,
2011
476.
Klyosov, A.A. Studies into mtDNA for DNA genealogy. Proceedings of the
Russian Academy of DNA Genealogy, vol. 4, No. 11, 2088-2092, 2011
477.
Klyosov, A.A. DNA genealogy – what is about, what does it determined, and for
whom it might be of interest. Proceedings of the Russian Academy of DNA Genealogy,
vol. 4, No. 11, 2157-2195, 2011.
478.
Rozhanskii, I.L., Klyosov, A.A. Mutation rate constants in DNA genealogy (Y
chromosome). Proceedings of the Russian Academy of DNA Genealogy, vol. 4, No. 12,
2202-2226, 2011.
479.
Klyosov, A.A. The origin of ancient subclades of R1b haplogroup – territories
and times. Proceedings of the Russian Academy of DNA Genealogy, vol. 4, No. 12,
2227-2245, 2011.
480.
Klyosov, A.A. On one old hypothesis of origin of the Kyrgyzes in the light of
DNA genealogy. Proceedings of the Russian Academy of DNA Genealogy, vol. 4, No.
12, 2251-2262, 2011.
481.
Klyosov, A.A. An interesting development of the story on the haplotype of
Pharaoh Tutankhamon and its origin. Proceedings of the Academy of DNA Genealogy,
vol. 5, No. 1, 2431-2436, 2012.
482.
Klyosov, A.A. DNA genealogy, archaeology, and linguistics: communication
problems. Part 1. Proceedings of the Academy of DNA Genealogy, vol. 5, No. 1, 24372455, 2012.
483.
Klyosov, A.A. DNA genealogy, archaeology, and linguistics: communication
problems. Part 2. Proceedings of the Academy of DNA Genealogy, vol. 5, No. 1, 24562472, 2012.
484.
Klyosov, A.A. On mtDNA of the Siberian Hunns. Proceedings of the Academy of
DNA Genealogy, vol. 5, No. 2, 20-29, 2012.
41
485.
Klyosov, A.A. An emerging pattern of L664 SNP mutation in the Tenths (bearers
of DYS388=10), North-Western branch of R1a1 haplotypes. Proceedings of the Academy
of DNA Genealogy, vol. 5, No. 2, 30-37, 2012.
486.
Klyosov, A.A., Rozhanskii, I.L. Haplogroup R1a as the Proto Indo-Europeans and
the Legendary Aryans as Witnessed by the DNA of Their Current Descendants
Proceedings of the Academy of DNA Genealogy, vol. 5, No. 3, 162-198, 2012.
487.
Klyosov, A.A. Where the Kelts came from? An introduction to the unsolved yet
problem. Proceedings of the Academy of DNA Genealogy, vol. 5, No. 4, 308-339, 2012.
488.
Klyosov, A.A. Haplotypes of haplogroups DE and F in Western Africa.
Proceedings of the Academy of DNA Genealogy, vol. 5, No. 4, 340-343, 2012.
489.
Klyosov, A.A. Finns as descendants of the tribes of Israel – pseudo-science again.
Consideration of the Finnish and South-Baltic haplotypes of haplogroup N1c1,
Proceedings of the Academy of DNA Genealogy, vol. 5, No. 4, 358-369, 2012.
490.
Klyosov, A.A. Linguistics and DNA genealogy: another attempt to find a mutual
understanding. Correspondence with Dr. S.V. Koncha. Proceedings of the Academy of
DNA Genealogy, vol. 5, No. 5, 422-523, 2012.
491.
Rozhanskii, I.L., Klyosov, A.A., Zolotarev, A.S. IRAKAZ – a database of
extended haplotypes of R1a haplogroup. Introductory notes. Proceedings of the Academy
of DNA Genealogy, vol. 5, No. 5, 553-559, 2012.
492.
Klyosov, A.A., Rozhanskii, I.L. Re-Examining the “Out of Africa” Theory and
the Origin of Europeoids (Caucasoids) in Light of DNA Genealogy. Proceedings of the
Academy of DNA Genealogy, vol. 5, No. 6, 632-648, 2012.
493.
Klyosov, A.A. Ancient History of the Arbins, Bearers of Haplogroup R1b, from
Central Asia to Europe, 16,000 to 1500 Years Before Present. Proceedings of the
Academy of DNA Genealogy, vol. 5, No. 6, 649-695, 2012.
494.
Klyosov, A.A. Excavated haplotypes of haplogroups G2a, E1b-V13 and I2a1 in
Spain and France. Proceedings of the Academy of DNA Genealogy, vol. 5, No. 6, 729731, 2012.
495.
Klyosov, A.A. Thinking over the book “Earlier Germans and their Neighbors.
Linguistics, Archaeology, Genetics” by Yu. K. Kuzmenko. Part 1. Proceedings of the
Academy of DNA Genealogy, vol. 5, No. 6, 732-745, 2012.
496.
Klyosov, A.A. On a graphic presentation of subclades of haplogroup R1a on the
42
FTDNA Project. Proceedings of the Academy of DNA Genealogy, vol. 5, No. 7, 793798, 2012.
497.
Klyosov, A.A. Louis Agassiz and his daguerreotypes. Proceedings of the
Academy of DNA Genealogy, vol. 5, No. 7, 799-831, 2012.
498.
Klyosov, A.A. A story with the subclade R1b-L51 in a curved mirror of
population genetics. Proceedings of the Academy of DNA Genealogy, vol. 5, No. 7, 832835, 2012.
499.
Klyosov, A.A. Thinking over the book “Earlier Germans and their Neighbors.
Linguistics, Archaeology, Genetics” by Yu. K. Kuzmenko. Part 2. Proceedings of the
Academy of DNA Genealogy, vol. 5, No. 7, 859-866, 2012.
500.
Klyosov, A.A. Microsatellites and genes of Y-chromosome. Proceedings of the
Academy of DNA Genealogy, vol. 5, No. 7, 911-913, 2012.
501.
Klyosov, A.A. On peoples of Lemba, South Africa. Proceedings of the Academy
of DNA Genealogy, vol. 5, No. 7, 914-919, 2012.
502.
Klyosov, A.A. Haplogroups of the African Bushmen. Proceedings of the
Academy of DNA Genealogy, vol. 5, No. 7, 954-958, 2012.
503.
Klyosov, A.A. Tilak’s fantasies on the Polar homeland of the Aryans. Proceedings
of the Academy of DNA Genealogy, vol. 5, No. 8, 966-978, 2012.
504.
Klyosov, A.A. On haplogroup “J1d” which are absent in the nomenclature and
classification of haplogroups and subclades. Proceedings of the Academy of DNA
Genealogy, vol. 5, No. 8, 1020-1025, 2012.
505.
Klyosov, A.A. Dating of haplogroups of Y-chromosome based on mutations in
haplotypes (STR) compared with dating based on SNPs in the “1000 Genomes” Project: a
story good to learn. Proceedings of the Academy of DNA Genealogy, vol. 5, No. 8, 10261034, 2012.
506.
Klyosov, A.A. Haplogroups and haplotypes of the Caucasus. Part 1. Proceedings
of the Academy of DNA Genealogy, vol. 5, No. 9, 966-1004, 2012.
507.
Klyosov, A.A. DNA genealogy of the Russian Princes of haplogroups N1c1 and
R1a. Proceedings of the Academy of DNA Genealogy, vol. 5, No. 9, 1037-1044, 2012.
508.
Klyosov, A.A. Dinaric (East-European) and the “Isles” branches of haplogroup
I2a. Proceedings of the Academy of DNA Genealogy, vol. 5, No. 11, 1304-1317, 2012.
509.
Klyosov, A.A. Haplotypes of haplogroup R1a on the Altai: autochtonous and
43
Proceedings of the Academy of DNA Genealogy, vol. 5, No. 12, 1511-1525, 2012.
510.
Klyosov, A.A. On a paper by the Hungarian authors “Brief Communications:
Novel binary markers of the Y chromosome improve the phylogenetic resolution within
haplogroup R1a” (Pamjav et al, Am. J. Phys. Anthropol., 2012). Proceedings of the
Academy of DNA Genealogy, vol. 5, No. 12, 1552-1564, 2012.
511.
Klyosov, A.A. The Jewish Levites J2a4b1 recent and ancient ancestors.
Proceedings of the Academy of DNA Genealogy, vol. 5, No. 12, 1582-1595, 2012.
512.
Klyosov, A.A. What is the “Admixture” and a new wave of distorted statements
and “conclusions” in genome studies. Proceedings of the Academy of DNA Genealogy,
vol. 5, No. 12, 1742-1757, 2012.
513.
Klyosov, A.A. “Autochtonous” and “Indo-European” haplotypes of the R1a
haplogroup in the South of India. Comments to the article by R. Spencer Wells, Colin
Renfrew, Chris Tyler Smith et al. “Population differentiation of Southern Indian male
lineages…” (PLOS one, November 2012). Proceedings of the Academy of DNA
Genealogy, vol. 6, No. 1, 2-17, 2013.
514.
Klyosov, A.A. Haplogroups and haplotypes of the Caucasus. Part 2. Eastern and
North-Eastern Caucasus. Proceedings of the Academy of DNA Genealogy, vol. 6, No. 1,
18-34, 2013.
515.
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45
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