BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Jennifer Kehlet Barton
Professor, Director, and Chair
Biomedical Engineering
eRA COMMONS USER NAME
barton
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
The University of Texas at Austin
The University of California, Irvine
The University of Texas at Austin
Positions
1988 -1994
1994 - 1998
1998 - pres.
2007 - pres.
2007 - pres.
DEGREE
(if applicable)
YEAR(s)
BS
MS
PhD
1988
1993
1998
FIELD OF STUDY
Electrical Engineering
Electrical Engineering
Biomedical Engineering
McDonnell Douglas (now Boeing Corp), Huntington Beach, CA. Engineer/Scientist Specialist.
University of Texas, Austin, TX. Research Assistant, Biomedical Engineering Program.
The University of Arizona, Tucson, AZ. Assistant (1998-7/2003), Associate (7/2003-2009), and
full (2009-pres.) Professor, Biomedical Engineering (primary appointment), Optical Sciences,
Electrical and Computer Engineering, Agricultural and Biosystems Engineering, Arizona Cancer
Center, Bio5 Institute.
Chair, Biomedical Engineering Graduate Interdisciplinary Program
Director, ARL Division of Biomedical Engineering
Awards and Affiliations
1996 & 1997 NASA/Texas Space Grant Fellowship
1996 - 1998 A.D. Hutchinson Fellowship, University of Texas Fellowship
1997
SPIE D.J. Lovell Scholarship
1998
Award for Excellence at the Student Interface, UA College of Engineering and Mines
2008
UA Leading Edge Researcher Award
Member:
AIMBE (fellow), ASLMS (fellow), BMES, IEEE, OSA, SPIE (fellow)
B. Selected peer-reviewed publications (in chronological order)
Barton JK, Milner TE, Pfefer TJ, Nelson JS, Welch AJ: Optical low coherence reflectometry to enhance Monte
Carlo modeling of skin. Journal of Biomedical Optics, 2(2):226-234, 1997.
Izatt JA, Kulkarni MD, Yazdanfar S, Barton JK, Welch AJ: In vivo bidirectional Doppler flow imaging of picoliter
blood volumes using optical coherence tomography. Optics Letters, 22(18):1439-1441, 1997.
Barton JK, Pfefer TJ, Welch AJ, Smithies DJ, Nelson JS, van Gemert MJC: Optical Monte Carlo modeling of a
true port wine stain anatomy. Optics Express 2, 391, 1998.
Barton JK, Izatt JA, Welch AJ: Investigating pulsed dye laser-blood vessel interaction with color Doppler
optical coherence tomography. Optics Express 2:251-256, 1998.
Barton JK, Izatt JA, Kulkarni MD, Yazdanfar S, and Welch AJ: Three-dimensional reconstruction of blood
vessels from in vivo color Doppler optical coherence tomography images. Dermatology, 198:355-361,
1999.
Barton JK, Hammer DX, Pfefer TJ, Lund TJ, Stuck BE, Welch AJ: Simultaneous irradiation and imaging of
cutaneous blood vessels. Lasers in Surgery and Medicine, 24:236-243, 1999.
Vargas G, Chan EK, Barton JK, Rylander HG, Welch AJ: Use of an agent to reduce scattering in skin. Lasers
in Surgery and Medicine, 24:133-141 1999.
Barton JK, Vargas G, Pfefer TJ, Welch AJ: Laser fluence for permanent damage of cutaneous blood vessels.
Photochemistry and Photobiology, 70:916-920, 1999.
Barton JK, Rollins A, Yazdanfar S, Pfefer TJ, Westphal V, Izatt JA: Photothermal coagulation of blood vessels:
a comparison of high-speed optical coherence tomography and numerical modeling. Physics in Medicine
and Biology, 46:1665-1678, 2001.
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Principal Investigator/Program Director (Last, First, Middle):
Barton, Jennifer Kehlet
Barton JK, Frangineas G, Pummer H, Black JF: Cooperative phenomena in two-pulse, two-color laser
photocoagulation of cutaneous blood vessels. Photochemistry and Photobiology, Jun;73(6):642-50, 2001.
Barton JK, Popok D, Black JF: Thermal analysis of blood undergoing laser photocoagulation. IEEE Journal of
Selected Topics in Quantum Electronics, 7:936-943, 2001.
Wong RC, Yazdanfar S, Izatt JA, Kulkarni M, Barton JK, Welch AJ, Willis J, Sivak MV: Visualization of
subsurface blood vessels by color Doppler-optical coherence tomography in rats: before and after
hemostatic therapy. Gastrointestinal Endoscopy, 55(1):88-95, 2002.
Rollins AM, Yazdanfar S, Barton JK, and Izatt JA: Real-time in vivo color Doppler optical coherence
tomography. Journal of Biomedical Optics, 7:123-129, 2002.
Gossage K, Tkaczyk T, Rodriguez J, Barton J:, Texture Analysis of Optical Coherence Tomography Images:
Feasibility for Tissue Classification,” Journal of Biomedical Optics 8:570-575, 2003.
Barton JK, Gossage KW, Xu W, Ranger-Moore J, Saboda K, Brooks CA, Duckett LD, Salache SJ, Warneke
JA, Alberts DS: Investigating sundamaged skin and actinic keratosis with optical coherence tomography: a
pilot study. Technology in Cancer Research and Treatment, 2:525-535, 2003.
Tumlinson AR, Hariri LP, Utzinger U, Barton JK: A miniature endoscope for simultaneous optical coherence
tomography- laser induced fluorescence. Applied Optics OT, 43:113-121, 2004.
BartonJK, Guzman F, Tumlinson AR: Dual modality instrument for simultaneous optical coherence tomography
imaging and fluorescence spectroscopy. Journal of Biomedical Optics, 9:618-623, 2004.
Alberding J, Barton JK, Wiley EB, Baldwin AL: Onset of pulsatile pressure causes transiently increased
filtration through artery wall. American Journal of Physiology, 286(5):H1827-35, 2004.
Loo C, Lin A, Hirsch L, Lee M, Barton J, Halas N, West J, Drezek R: Nanoshell-enabled photonics-based
imaging and therapy of cancer. Technology in Cancer Research and Treatment, 3:33-40, 2004.
Black JF and Barton JK: Chemical and Structural Changes in Blood Undergoing Laser Photocoagulation.
Photochemistry and Photobiology, 80:89-97, 2004.
Brewer M, Utzinger U, Barton JK, Hoying JB, Kirkpatrick ND, Brands WR, Davis JR, Hunt K, Stevens SJ,
Gmitro AF, Imaging of the Ovary, Technology in Cancer Research and Treatment, 3: 617-628, 2004.
Kariya R, Mathine DL, Barton JK: Analog CMOS Circuit Design and Characterization for Optical Coherence
Tomography Signal Processing, IEEE Transactions on Biomedical Engineering, 51(12):2160-3, 2004.
Black JF, Wade N, Barton JK: Mechanistic comparison of blood undergoing laser photocoagulation at 532 and
1,064 nm,” Lasers Surg. Med. 36:155-165, 2005.
Barton JK, Stromski S, "Flow measurement without phase information in optical coherence tomography
images," Optics Express, 13:5234-5239, 2005.
Gossage KW, Smith CM, Kanter EM, Hariri LP, Stone AL, Rodriguez JJ, Williams SK, Barton JK, “Texture
analysis of speckle in optical coherence tomography images of tissue phantoms", Physics in Medicine and
Biology, 51:1563-1575, 2006.
Hariri LP, Tumlinson AR, Wade NH, Besselsen D, Utzinger U, Gerner E, Barton JK, “Endoscopic optical
coherence tomography and laser induced fluorescence spectroscopy in a murine colon cancer model,”
Lasers in Surgery and Medicine, 38:305-313, 2006.
Xu W, Bonnema GT, Gossage KW, Wade NH, Medford J, Barton JK, “Customized analog circuit design for
fiber based optical coherence microscopy,” Review of Scientific Instruments 77: 016104, 2006.
McNally J, Kirkpatrick N, Hariri LP, Tumlinson AR, Besselsen D, Gerner E, Urs Utzinger U, Barton J., “Task
Based Imaging of Colon Cancer in a Mouse Model (ApcMin/+),” Applied Optics, 45: 3049-3062, 2006.
Kanter EM, Walker RM, Marion SL, Brewer M, Hoyer PB, Barton JK, “Dual modality imaging of a novel rat
model of ovarian carcinogenesis,” Journal of Biomedical Optics, 11: 041123, 2006.
Agrawal A, Huang S, Wei A, Lin H, Lee M, Drezek R, Barton JK, Pfefer J, “Quantitative evaluation of optical
coherence tomography signal enhancement with gold nanoshells,” Journal of Biomedical Optics, 11:
041121, 2006.
Tumlinson AR, Barton JK, Povazay B, Sattman H, Unterhuber A, Leitgeb RA, Drexler W, “Endoscope-tip
interferometer for ultrahigh resolution frequency domain optical coherence tomography in mouse colon,”
Optics Express, 14: 1878-1887, 2006.
Xu W, Mathine DL, Barton JK, “High-gain differential CMOS transimpedance amplifier with on-chip buried
double junction photodiode,” Electronics Letters 42(14):803-5, 2006.
Tumlinson AR, Povazay B, Hariri LP, McNally J, Unterhuber A, Hermann B, Sattmann H, Drexler W, Barton
JK, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized
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Principal Investigator/Program Director (Last, First, Middle):
Barton, Jennifer Kehlet
endoscope,” Journal of Biomedical Optics, 11:064003, 2006.
Hariri LP, Qiu L, Tumlinson AR, Besselsen DG, Gerner EG, Ignatenko N, Povazay B, Hermann B, Sattmann H,
McNally J, Unterhuber, Drexler W, Barton JK, “Serial endoscopy in azoxymethane treated mice using
ultrahigh resolution optical coherence tomography,” Cancer Biology and Therapy, 6:11 1-10, 2007.
Korde V, Bonnema G, Xu W, Krishnamurthy C, Ranger-Moore J, Saboda K, Slayton L, Salasche S, Warneke
J, Alberts D, and Barton JK, “Using Optical Coherence Tomography to Evaluate Skin Sun Damage and
Precancer,” Lasers in Surgery and Medicine, 39:687-695, 2007.
Luo Y, Arauz L, Castillo J, Barton JK, Kostuk R, “Parallel Optical Coherence Tomography System” Applied
Optics, 46(34):8291-7, 2007.
Xu W, Mathine DL, Barton JK, “Analog CMOS design for optical coherence tomography signal detection and
processing,” IEEE Transactions on Biomedical Engineering, 55(2):485-9, 2008.
Tumlinson AR, Hofer B, Winkler A, Povazay B, Drexler W, Barton JK, Inherent homogenous media dispersion
compensation in frequency domain optical coherence tomography by accurate “k-sampling,” Applied Optics
47(5):687-93, 2008.
Black KC, Kirkpatrick ND, Troutman TS, Xu L, Vagner J, Gillies RJ, Barton JK, Utzinger U, Romanowski M,
“Gold nanorods targeted to delta opioid receptor: plasmon-resonant contrast and photothermal agents,”
Molecular Imaging 7(1):50-7, 2008.
Luo Y, Gelsinger PJ, Barton JK, Barbastathis G, Kostuk RK, “Optimization of multiplexed holographic gratings
in PQ-PMMA for spectral-spatial imaging filters,” Opt Lett 33:566-8, 2008.
Vargas G, Barton JK, Welch AJ “The Use of Hyper-osmotic Chemical Agent to Improve the Laser Treatment of
Cutaneous Vascular Lesions,” Journal of Biomedical Optics, 13:021114, 2008.
Troutman T, Barton JK, Romanowski MR “Biodegradable Plasmon Resonant Nanoshells,” Advanced
Materials, 20:2604-2608, 2008.
Arauz LJ, Luo Y, Castillo JE, Barton JK, Kostuk RK “Fiber Array Fabrication Technique for 15µm Diameter
Single Mode Fibers,” Optical Engineering, 47: 074002, 2008.
Bonnema GT, O’Halloran Cardinal K, Williams SK, Barton JK “An automatic algorithm for detecting stent
endothelialization from volumetric optical coherence tomography datasets,” Physics in Medicine and
Biology, 53:3083-3098, 2008.
Luo Y, Gelsinger-Austin PJ, Watson JM, Barbastathis G, Barton JK, Kostuk RK, “Laser-induced fluorescence
imaging of subsurface tissue structures with a volume holographic spatial-spectral imaging system,” Opt
Lett. 33(18):2098-2100, 2008.
Zhang Y, Davidson BR, Stamer WD, Barton JK, Marmorstein L, Marmorstein AD, “Enhanced inflow and
outflow rates despite lower IOP in Bestrophin-2 deficient mice,” Invest Ophthalmol Vis Sci. 50:765-70,
2009.
Hoyer PB, Davis JR, Bedrnicek JB, Marion SL, Christian PJ, Barton JK, Brewer MA, "Ovarian neoplasm
development by 7,12-dimethylbenz[a]anthracene (DMBA) in a chemically-induced rat model of ovarian
failure,” Gynecological Oncology, 112:610615, 2009.
C. Research Support
Active
“Dual-modality system for imaging colon cancer in mice”
07/01/04-04/30/09 ncx /10 (renewal: 2.6%)
Principal Investigator: Jennifer Barton
National Institutes of Health/NCI R01 CA109835
This grant funds development of a dual modality imaging system (optical coherence tomography and
fluorescence spectroscopy) and the application of this system to minimally invasive imaging of mouse colon
cancer models.
“Chemoprevention of Skin Cancer”
07/01/04-06/30/09
Principal Investigator: David Alberts (Barton Co-Investigator)
Agency: National Institutes of Health/NCI P01 CA27502
Barton’s role in the grant is to develop optical coherence tomography as a non-invasive biomarker for skin
sundamage and chemopreventive agent efficacy.
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Principal Investigator/Program Director (Last, First, Middle):
Barton, Jennifer Kehlet
“Optical Imaging of Ovarian Carcinogenesis in a Novel Rat Model”
12/12/06-12/11/11
Principal Investigator: Jennifer Barton
Agency: National Institutes of Health/ NCI R01 CA119200
A novel post-menopausal rat model of ovarian cancer will be developed under this grant and imaged with
optical coherence tomography, optical coherence microscopy, and laser-induced fluorescence. Technology
development will include miniature OCT and OCM probes.
“Novel Superluminescent LEDs and UHR OCT for Medical Imaging Applications” 4/1/07-6/30/09
Dual PI: Jennifer Barton, together with Yong-Hang Zhang, Arizona State University
Agency: ASU-UA Collaborative on Biomedical Research
A new class of SLED light sources will be developed for optical coherence tomography applications, with broad
bandwidth and high power. They will be tested in a broadband OCT system with various tissue samples.
“Optical Holographic Spatial-Spectral Imaging”
08/25/06-07/31/09
Principal Investigator: Raymond Kostuk (Barton Co-investigator)
National Institutes of Health/NCI R21 CA118167
This grant funds development of an imaging system capable of simultaneously obtaining three spatial and one
spectral dimensions.
“Cardiovascular Biomedical Engineering”
04/01/00-06/30/11
Principle Investigator: Jennifer Barton
Type: Training Grant
Agency: National Institutes of Health/NHLBI T32 HL007955
This grant funds student training in the field of cardiovascular biomedical engineering
Completed in last three years
“Advanced Intravital Microscope”
04/01/07-03/31/09
Principle Investigator: Urs Utzinger (Barton Co-PI)
Type: Shared Instrumentation Grant
Agency: National Institutes of Health/NCRR S10 RR23737
This grant will support the purchase of components to create an advanced intravital microscope, with
multiphoton imaging capabilities and the ability to measure tissue cultures and small animals.
“Molecular Targeted Imaging in Colon Cancer”
10/01/07-09/30/08
Principle Investigator: Joseph Backer, SibTec, Inc. (Barton subcontract PI)
Agency: National Institutes of Health/ NCI R43 CA132528
This grant funds development of a fluorescence contrast agent targeted to the VEGF receptor. The subcontract
is to image this agent in a mouse model using endoscopic OCT/LIF
“Imaging the Vascular Response to Implants”
07/01/02-06/30/07
Principal Investigator: Jennifer Barton
Agency: National Institutes of Health/NIBIB K02 EB000163
This independent scientist award provides salary support and relief from some teaching/service activities, so
that more time can be spent on research.
“Parallel Optical Coherence Tomography for Endoscopic Imaging”
10/01/02-03/30/07
Principle Investigator: Jennifer Barton
Agency: National Institutes of Health/NIBIB R01 EB01032
This project fund development of a novel, parallel-imaging OCT system, using arrays of superluminescent
diodes, detectors, and CMOS processing channels.
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