Publications of Dr. Hing-Chung Lam 林興中醫師著作 Referred Papers(醫學雜誌論文) 1. LT Ho, HC Lam, JT Wang, KT Tang, JC Perng, YF Liu, RL Chen. Establishment of a radioimmunoassay of somatostatin in human plasma and in rat hypothalamus. Chin Physiol. 1986;29:91-103. 2. HC Lam, SH Li, JT Wang, KT Tang, LT Ho. The antilipemic effectiveness of aluminium clofibrate on hyperlipidemic patients with or without diabetes mellitus. Chin Med J (Taipei). 1987;40:463-70. 3. JT Wang, LT Ho, KT Tang, HC Lam, LM Wang, KN Ching. Two compartment pharmacodynamics of somatostatin in non-obese non-insulin dependent diabetes. Chin Med J(Taipei). 1987;40:505-10. 4. KT Tang, LT Ho, JT Wang, HC Lam, SH Li, LJ Hsiao, JC Perng, YF Liu. Skin microvascular reflexes in patients with diabetic autonomic neuropathy. Chin Med J(Taipei)1988;41:57-62. 5. HC Lam, KT Tang, JT Wang, YF Liu, LM Wang, LT Ho. Immunogenicity of monocomponent human and porcine insulin in non-insulin-dependent diabetes mellitus. Chin Med J (Taipei).1988;41:217-22. 6. KT Tang, LT Ho, LM Wang, HC Lam, JT Wang, KN Ching, CF Kwok, JS Jap. Reflex heart rate response in normal Chinese adults: its relationship to age. J Formosan Med Assoc. 1988;87:677-85. 7. HC Lam, LT Ho, KT Tang, KN Ching. Primary hyperparathyroidism and coexisting hyperthyroidism: Review of the literature. Chin Med J(Taipei).1989,43:105-12. 8. HC Lam, LT Ho, KT Tang, LM Wang, CF Kwok, YF Liu, LJ Hsiao, SH Li. Immunogenicity of highly purified porcine and human insulins in diabetic patients with high titers of insulin antibody. J Formosan Med Assoc. 1989;88:346-51. 9. HC Lam, LT Ho, KT Tang, KN Ching. Concurrent Hyperthyroidism and Hyperparathyroidism:Influence of hyperthyroidism of serum magnesium, free calcium and parathyroid hormone. J Formosan Med Assoc. 1989;88:601-5. 10. TC Liu, HC Lam, LT Ho. Cushing's Syndrome: Analysis of 188 cases. J Formosan Med Assoc. 1989;88:886-93.(Correspondent author) 11. KT Tang, LT Ho, TS Jap, TC Chang, KN Ching, HC Lam, MS Wu, SP Lee. Comparison of insulin secretion and insulin sensitivity between normal and impaired glucose tolerance subjects with normal fasting plasma glucose. Chin Med J (Taipei)1990;46:73-8. 12. HC Lam, K Takahashi, MA Ghatei, SR Bloom. Presence of immunoreactive endothelin in human milk. FEBS Lett 1990; 261:184-6. 13. K Takahashi, MA Ghatei, HC Lam, DJ O'Halloran, SR Bloom. Elevated plasma endothelin in patients with diabetes mellitus. Diabetologia 1990;33:306-10. 14. K Takahashi, PM Jones, SM Kanse, HC Lam, RA Spokes, MA Ghatei, SR Bloom. Endothelin in the gastrointestinal tract:presence of endothelin-like immunoreactivity, endothelin-1 mRNA, endothelin receptors and its pharmacological effect. Gastroenterology 1990;99:1660-7. 15. HC Lam, Takahashi, MA Ghatei, SM Kanse, JM Polak, SR Bloom. Binding site of a novel neuropeptide pituitary-adenylate-cyclase-activating polypeptide in the rat brain and lung. Eur J of Biochem 1990;193:725-9. 16. K Takahashi, A Silva, J Cohen, HC Lam, MA Ghatei, SR Bloom. Endothelin immunoreactivity in mice with Gram-negative bacteraemia:relationship with tumor necrosis factor-alpha. Clin Sci 1990;79:619-23. 17. LT Ho, HC Lam, MS Wu, CF Kwok, TS Jap, KT Tang, LM Wang, YF Liu. A twelve-month double-blind randomized study of the efficacy and immunogenicity of human and porcine insulin in non-insulin-dependent diabetics. Chin Med J (Taipei)1991;47:313-9. 18. K Takahashi, MA Ghatei, PM Jones, JK Murphy, HC Lam, DJ O'Halloran, SR Bloom. Endothelin in the human brain and pituitary gland:presence of immunoreactive endothelin, endothelin mRNA and endothelin receptors. J Clin Endocrinol Metab 1991; 72:693-9. 19. K Takahashi, K Suda, HC Lam, MA Ghatei, SR Bloom. Endothelin-like immunoreactivity in rat models of diabetes mellitus. J Endocrinol 1991;130:123-7. 20. HC Lam, K Takahashi, MA Ghatei, AN Warrens, AJ Rees, SR Bloom. Immunoreactive endothelin in human plasma, urine, milk and saliva. J Cardiovasc Pharmacol 1991; 17(Suppl 7):S390-3. 21. K Takahashi, MA Ghatei, PM Jones, JK Murphy, HC Lam, DJ O'Halloran, SR Bloom. Endothelin in human brain and pituitary gland. Comparison with the rat. J Cardiovasc Pharmacol 1991;17(Suppl 7):S101-3. 22. HC Lam, K Takahashi,MA Ghatei,K Suda,SM Kanse,SR Bloom. Presence of immunoreactive endothelin in human saliva and rat parotid gland. Peptides 1991;12:883-5. 23. SM Kanse, K Takahashi, HC Lam, A Rees, J Warren, MA Ghatei, SR Bloom. Effect of cytokines on endothelin release from bovine aortic and pulmonary arterial endothelial cells. Life Sci 1991;48:1379-84. 24. MC Shih, KH Chen, LR Yeh, HC Lam, TM Han, JK Lee, JM Chang, CF Yang. Pachydermoperiostosis- a case report. Chinese J Radiology 1993;18:411-5. 25. HC Lam, JP Wang, JK Lee, LT Ho, TM Han, CC Lu, HT Chiang, DL Cheng. Tissue contents of endothelin vary according to thyroid hormone status in rat. J Cardiovasc Pharmacol 1993; 22(Suppl 8): S299-S302. 26. HC Lam, JP Wang, JK Lee, LT Ho, TM Han, CC Lu, HT Chiang, DL Cheng, SR Bloom. The lung contents of endothelin are altered by thyroid hormone status in rat. Regul Peptides 1993; 49: 33-9. 27. CC Lu, JK Lee, HC Lam, CY Yang, TM Han. Insulin autoimmune syndrome in a patient with methimazole and carbimazole-treated Grave's disease : a case report . Chin Med J (Taipei) 1994; 54 : 353-8. 28. CY Yang, HC Lam, CC Lu, TM Han, JK Lee . MELAS syndrome associated with diabetes mellitus and hyperthyroidism: a case report from Taiwan. Clin Endocrinol 1995;43:235-9. 29. HC Lam, JK Lee, HT Chiang. Does endothelin play a role in the pathogenesis of early diabetic nephropathy ? J Cardiovasc Pharmacol 1995;26(Suppl 3):S479-81. 30. HC Lam, JK Lee, SJ Koh, HT Chiang. Acute effect of captopril on urinary excretion of endothelin in normal Chinese subjects. Adrenal Glands, Vascular System and Hypertension. Eds GP Vinson & DC Anderson. Journal of Endocrinology Ltd, Bristol, 1996, pp 253-257. 31. LJ Hao, TM Han, CY Yang, CC Lu, HC Lam, JK Lee. Late-onset idiopathic hypoparathyroidism with thymoma:A case report. Chin Med J (Taipei) 1996; 57 : 146-51. 32. JK Lee, MJ Chuang, CC Lu, LJ Hao, CY Yang, TM Han, HC Lam. Parathyroid hormone and parathyroid hormone related protein assays in the investigation of hypercalcemic patients in hospital in a Chinese population. J Endocrinol Invest 1997;20:404-9. 33. HC Lam, JK Lee, HT Chiang, MJ Chuang, MC Wang. Is captopril-induced improvement of insulin sensitivity mediated via endothelin ? J Cardiovasc Pharmacol 1998;31(Suppl 1):S496-500. 34. CH Chu, TM Han, SY Lou, HC Lam, CC Lu, JK Lee. Parathyroid storm- A case report. J Intern Med Taiwan 1998;9:142-7. 35. GH Lo, HC Lam, JT Cheng, JK Lin, JH Hsu, KH Lai, HT Chiang. Serum endothelin and atrial natriuretic peptide in cirrhotic patients with ascites and hepatorenal syndrome. Chin Med J (Taipei) 1998;61:596-602. 36. JY Li, PH Lai, HC Lam, LY Lu, HH Cheng, JK Lee, YK Lo. Hypertrophic cranial pachymeningitis and lymphocytic hypophysitis in Sjogren's syndrome. Neurology 1999;52:420-3. 37. Chu CH, Lee JK, Lam HC, Lu CC. The occurrence of diabetic ketoacidosis in type 2 diabetic adults. J Intern Med (Taiwan) 1999;10:230-5. 38. CH Chu, JK Lee, MJ Chuang, MC Wang, CC Lu, HC Lam. Cystic papillary carcinoma of the thyroid with ultrasonographic "calcified nodule in cyst" sign. Report of a case. J Med Ultrasound 2000;8:35-8.(Correspondent author) 39. HC Lam, JK Lee, KH Lai, HT Chiang. Plasma endothelin levels are unaltered by thyroid hormone status in humans. J Cardiovasc Pharmacol 2000;36(Suppl.1)S382-5. 40. HC Lam, JK Lee, KH Lai, HT Chiang. Detection and characterization of endothelin in transformed human osteoblast cell culture medium. Endocrine 2000;12:77-80. 41. HC Lam. Review:Role of endothelin in diabetic vascular complications. Endocrine 2001;14:277-284. 42. CH Chu, JK Lee, HC Lam, CC Lu. Prognostic factors of hyperglycemic hyperosmolar nonketotic state. Chang Gung Med J 2001;24:345-51. 43. CH Chu, MJ Chuang, MC Wang, HC Lam, CC Lu, JK Lee. Sclerotherapy of thyroid cystic nodules. J Formos Med Assoc 2003;102:625~30. 44. HC Lam, JK Lee, CC Lu, CH Chu, MJ Chuang, MC Wang. Role of Endothelin in Diabetic Retinopathy Curr Vasc Pharmacol 2003;1:243-50. 45. CC Lu, HC Lam, CH Chu, MJ Chuang, MC Wang, JK Lee. 1,5-anhydroglucitol levels in type 2 diabetic and non-diabetic subjects in southern Taiwan. Endocrinologia & Metabologia 2003;47:711~5. 46. LJ Hao, CY Yang, HC Lam, JK Lee. Hypoparathyroidism. J Intern Med Taiwan 2003; 14 : 264-51. 47. HC Lam, GH Lo, JK Lee, CC Lu, CH Chu, CC Sun, MJ Chuang, MC Wang. Salivary Immunoreactive Endothelin in Patients with Upper Gastrointestinal Diseases J Cardiovasc Pharmacol 2004;44(Suppl 1):S413-7. 48. HC Lam, JK Lee, CC Lu, CH Chu, CC Sun, MJ Chuang, MC Wang. Immunoreactive Endothelin in Southern Taiwanese Thyroid Cyst Fluid J Cardiovasc Pharmacol 2004;44(Suppl 1):S418-20. 49. MC Wang, HC Lam, CC Lu, CH Chu, CC Sun, MJ Chuang, JK Lee. Evaluate the validity period of glucose test strip after its exposure. J Biomed Lab Sci 2004;2:56-60. 50. CC Sun, HC Lam, CC Lu, CH Chu, JK Lee. Thyrotoxic Periodic Paralysis in Southern Taiwan. T.S.M.H. Medical & Nurs J (Tian-Sheng Memorial Hospital)2005;11:93-102. 51. SJ Sheu, LC Chou, YS Bee, JF Chen, HC Lin, PR Lin, HC Lam, MH Tai. Suppression of choroidal neovascularization by intramuscular polymer-based gene delivery of vasostatin. Exp Eye Res 2005;81:673-9. 52. GS Liu, LF Liu, CJ Lin, JC Tseng, MJ Chuang, HC Lam, JK Lee, LC Yang, JHY Chan, SL Howng, MH Tai. Gene transfer of pro-opiomelanocortin prohormone suppressed the growth and metastasis of melanoma: involvement of alpha-melanocyte-stimulating hormone-mediated inhibition of the nuclear factor kB/cyclooxygenase-2 pathway. Mol Pharmacol 2006;69:440-51. 53. HC Lam, CH Chu, MC Wei, HM Keng, CC Lu, CC Sun, JK Lee, MJ Chuang, MC Wang, MH Tai. The effects of different doses of atorvastatin on plasma endothelin-1 levels in type 2 diabetic patients with dyslipidemia. Exp Biol Med 2006;231:1010-5. 54. HC Lam, SM Kuo, MJ Chuang, HM Keng, PR Lin, GS Liu, CM Hsu, SL Howng, MH Tai. Blockade of endothelin-1 release contributes to the anti-angiogenic effect by pro-opiomelanocortin overexpression in cultured endothelial cells. Exp Biol Med 2006;231:782-8. 55. CH Chu, JK Lee, HM Keng, MJ Chuang, CC Lu, MC Wang, CC Sun, MC Wei, HC Lam. Hyperthyroidism is associated with higher plasma endothelin-1 concentrations. Exp Biol Med 2006;231:1040-3.(Correspondent author) 56. MH Tai, SM Kuo, HT Liang, KR Chiou, HC Lam, CM Hsu, HJ Pownall, HH Chen, MT Huang, CY Yang. Modulation of angiogenic processes in cultured endothelial cells by low density lipoproteins subfractions from patients with familial hypercholesterolemia. Atherosclerosis. 2006;186:448-57. 57. MC Wang, HC Lam, CC Lu, CH Chu, CC Sun, MJ Chuang, YT Chuang, JK Lee. The Evaluation of The Second Generation Assay for Measuring TSH Receptor Antibody in Graves’Disease. Cheng Ching Med J 2006;2:4-10. 58. JK Lee, CH Chu, MJ Chuang, SC Lin, MC Wang, CC Lu, CC Sun, HC Lam. Two-year effect of rosiglitazone in chinese poorly controlled type 2 diabetic patients. Chang Gung Med J 2006;29:486-92. 59. MH Tai, WT Weng, WC Lo, JY Chan, CJ Lin, HC Lam, CJ Tseng. Role of Nitric Oxide in {alpha}-MSH-induced Hypotension in the Nucleus Tractus Solitarii of the Spontaneously Hypertensive Rats. J Pharmacol Exp Ther 2007;321:455-61. 60. JC Tseng, LY Lu, RJ Hu, CK Kau, HH Cheng, PR Lin, CW Sun, HT Liang, HC Lam, MH Tai. Elevated serum anti-endothelial cell autoantibodies titer is associated with lupus nephritis in patients with systemic lupus erythematosus. J Microbiol Immunol Infect 2007;40:50-5. 61. CH Chu, MC Wang, TH Sun, JK Lee, HC Lam. Very low HbA1c values in a patient with clinical silent hemoglobin variant (hemoglobin J)--a case report. J Intern Med Taiwan 2007;18:45-50. 62. CH Chu, JK Lee, HC Lam, CC Lu, CC Sun, MC Wang, MJ Chuang, MC Wei. Atorvastatin does not affect insulin sensitivity and the adiponectin or leptin levels in hyperlipidemic type 2 diabetes. J Endocrinol Invest 2008;31:42-7. 63. YL Bai, CP Chiou, YY Chang, HC Lam. Correlates of depression in type 2 diabetic elderly patients: a correlational study. Int J Nurs Stud 2008;45:571-9. 64. MC Wang, CH Chu, JK Lee, CC Lu, CC Sun, MC, MJ Chuang, Tsai HK, Cheng HJ, HC Lam. The factors that influence the measurement of glycohemoglobin. T.S.M.H. Medical & Nurs J (Tian-Sheng Memorial Hospital) 2008;14:17-26.(Correspondent author) 65. MC Wang, CH Chu, JK Lee, CC Lu, Ho ST, CC Sun, MJ Chuang, HK Tsai, HJ Cheng, HC Lam. The frequency of detection of hemoglobin variants in diabetic patients indentified by abnormal hemoglobin chromatograms through routine use of an A1c analyzer Tosoh HLC-723 G5.. Cheng Ching Med J 2008;4:51-8. (Correspondent author) 66. CH Chu, JK Lee, MC Wang, CC Lu, CC Sun, MJ Chuang, HC Lam. Change of Visfatin, C-Reactive Protein Concentrations and Insulin Sensitivity in Patients with Hyperthyroidism. Metabolism. 2008;57:1380-3. (Correspondent author) 67. CC Lu, BP Jiann, CC Sun, HC Lam, CH Chu, JK Lee. Association of glycemic control with risk of erectile dysfunction in men with type 2 diabetes. J Sex Med 2009;6:1719-28. 68. BP Jiann, CC Lu, HC Lam, CH Chu, CC Sun, JK Lee. Patterns and their correlates of treatment seeking for erectile dysfunction in type 2 diabetic patients. J Sex Med 2009;6:2008-16. 69. CH Chu, HC Lam, JK Lee, MC Wang, CC Lu, CC Sun, MJ Chuang. Common hemoglobin variants in southern Taiwan and their effect on the determination of HbA1c by ion-exchange high-performance liquid chromatography. J Chin Med Assoc 2009;72:362-7. 70. HJ Cheng, CH Chu, CC Lu, PC Wang, SJ Lin, CC Sun, MC Wang, JK Lee, MJ Chuang, HK Tsai, HC Lam. Color doppler sonography of the neck in a patient with bilateral carotid body tumors. J Med Ultrasound 2009;17:114-119. (Correspondent author) 71. MC Wang, PC Chiou, HJ Cheng, HK Tsai, SJ Tsai, HY Tsai, CM Wu, MJ Chuang, HC Lam. Persistent hyperinsulinemic hypoglycemia of infancy-PHHI: a case report. J Biomed Lab Sci 2009;21:29-33.(Correspondent author) 72. GS Liu, JY Shi, CL Lai, YR Hong, SJ Shin, HT Huang, HC Lam, ZH Wen, KS Hsu, CH Chen, SL Howng, MH Tai. Peripheral gene transfer of glial cell-derived neurotrophic factor ameliorates neuropathic deficits in diabetic rats. Hum Gene Ther 2009;20:715-27. 73. GS Liu, HT Huang, CJ Lin, JY Shi, LF Liu, RT Tseng, WT Weng, HC Lam, ZH Wen, TL Cheng, KS Hsu, MH Tai. Prophylactic proopiomelanocortin expression alleviates capsaicin-induced neurogenic inflammation in rat trachea. Shock 2009;32:645-50. 74. HY Tsai, SJ Tsai, CC Lu, CC Sun, HK Tsai, HJ Cheng, CM Wu, CH Chu, JK Lee, HC Lam. Clinical analysis of hepatocellular carcinoma complicated with hypoglycemia at a southern Taiwan medical center. Formos J Endocrin Metab 2010;1:1-4.(Correspondent author) 75. SJ Tsai, MC Wang, CC Lu, HC Lam. Pseudohypercalcemia due to hyperlipidemia-a case report. Formos J Endocrin Metab 2010;1:14-8.(Correspondent author) 76. HK Tsai, JK Chen, HJ Cheng, HY Tsai, SJ Tsai, CM Wu, CC Lu, CH Chu, CC Sun, JK Lee, HC Lam. Graves' disease with ANCA-positive vasculitis and pulmonary hemorrhage-a case report. Formos J Endocrin Metab 2010;1:23-7.(Correspondent author) 77. GS Liu, HE Tsai, WT Weng, LF Liu, CH Weng, MR Chuang, HC Lam, CS Wu, R Tee, ZH Wen, SL Howng, MH Tai. Systemic Pro-opiomelanocortin Expression Induces Melanogenic Differentiation and Inhibits Tumor Angiogenesis in Established Mouse Melanoma. Hum Gene Ther 2011;22:325-35 78. CH Chu, HC Lam, JK Lee, CC Lu, CC Sun, MC Wang, MJ Chuang. Hyperthyroidism-associated insulin resistance is not mediated by adiponectin levels. J Thyroid Res 2011;2011:Article ID 194721, doi:10.4061/2011/194721. 79. CH Chu, HC Lam, JK Lee, CC Lu, CC Sun, HJ Cheng, MC Wang, MJ Chuang. Elevated serum retinol-binding protein 4 concentrations are associated with chronic kidney disease but not with the higher carotid intima-media thickness in type 2 diabetic subjects. Endocr J 2011;58:841-7. 80. HM Kuo, CY Lin, HC Lam, PR Lin, HH Chan, JC Tseng, CK Sun, TF Hsu, CC Wu, CY Yang, CM Hsu, MH Tai. PTEN Overexpression Attenuates Angiogenic Processes of Endothelial Cells by Blockade of Endothelin-1/Endothelin B Receptor Signaling. Atherosclerosis 2012;221:341-9. 81. CH Chu, HC Lam, JK Lee, CC Lu, CC Sun, HJ Cheng, MC Wang, MJ Chuang. Carotid intima-media thickness in Chinese type 2 diabetic subjects with or without microalbuminuria. J Endocrinol Invest 2012;35:254-9. 82. CY Wang, CL Lin, TS Huang, MN Chien, SH Hsieh, YY Huang, KC Shih, ST Tu, CT Chang, Chien-Ning H, CW Chou, TJ Wu, RT Liu, HC Lam, CF Kwok, CC Fu, WH Sheu. Inertia on hypoglycemia: highlight from a Taiwan subgroup analysis of Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) study. Diabetes Res Clin Pract 2012;98:61-7. 83. HW Tseng, HS Lin, HC Lam. Co-morbidities in psoriasis: a hospital-based case-control study. J Eur Acad Dermatol Venereol 2012 Nov 8. doi: 10.1111/jdv.12028. [Epub ahead of print](Correspondent author) 84. HE Tsai, GS Liu, ML Kung, LF Liu, JC Wu, CH Tang, CH Huang, SC Chen, HC Lam, CS Wu, MH Tai. Downregulation of Hepatoma-Derived Growth Factor Contributes to Retarded Lung Metastasis via Inhibition of Epithelial-Mesenchymal Transition by Systemic POMC Gene Delivery in Melanoma. Mol Cancer Ther 2013;12:1016-25. 85. SJ Sheu , NC Liu, LP Ger, WL Ho, JY Lin, SC Chen, YH Horng, HC Lam. High HbA1c level was the most important factor associated with prevalence of diabetic retinopathy in Taiwanese type II diabetic patients with a fixed duration. Graefes Arch Clin Exp Ophthalmol 2013 Mar 17.[Epub ahead of print] 86. MS Hung, WL Tsai, TJ Tsai, CH Chu, CC Sun, HJ Cheng,JK Lee, HC Lam. Hypertriglyceridemia-associated acute pancreatitis in pregnancy. Formos J Endocrin Metab 2013;4:4-8.(Correspondent author) 87. WC Chuang, JK Lee, CJ Chen, SI Liu, MS Hung, HJ Cheng, CH Chu, CC Sun, CC Lu, SJ Lin, HC Lam. Malignant lymphoma of the thyroid gland-a case report. Formos J Endocrin Metab 2013;4:9-12.(Correspondent author) 88. JL Liu, CCh Tsa,JK Lee, HJ Cheng, CH Chu, CC Sun, HC Lam. Multiple endocrine neoplasia type 2 with bilateral malignant pheochromocytoma and medullary thyroid carcinoma: A Case Report. Formos J Endocrin Metab 2014;in press.(Correspondent author)