Publications First Quarter 2015
Al-Shehri A, Favretto ME, Ioannou PV, Romero IA, Couraud PO, Weksler BB, Parker
TL, Kallinteri P. Permeability of PEGylated Immunoarsonoliposomes Through In Vitro
Blood Brain Barrier-Medulloblastoma Co-culture Models for Brain Tumor Therapy.
Pharm Res. 2015 Mar;32(3):1072-83.
Antony PM, Boyd O, Trefois C, Ammerlaan W, Ostaszewski M, Baumuratov AS,
Longhino L, Antunes L, Koopman W, Balling R, Diederich NJ. Platelet mitochondrial membrane potential in Parkinson's disease. Annals of clinical and translational neurology. 2015 Jan;2(1):67-73.
Blanchet L, Smeitink JA, van Emst-de Vries SE, Vogels C, Pellegrini M, Jonckheere AI,
Rodenburg RJ, Buydens LM, Beyrath J, Willems PH, Koopman WJ. Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning. Sci Rep. 2015;5:8035.
Dhanasekaran R, Nakamura I, Hu C, Chen G, Oseini AM, Seven ES, Miamen AG,
Moser CD, Zhou W, van Kuppevelt TH, van Deursen JM, Mounajjed T, Fernandez-
Zapico ME, Roberts LR. Activation of the transforming growth factor-beta/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma. Hepatology. 2015 Apr;61(4):1269-83.
Distelmaier F, Valsecchi F, Liemburg-Apers DC, Lebiedzinska M, Rodenburg RJ, Heil
S, Keijer J, Fransen J, Imamura H, Danhauser K, Seibt A, Viollet B, Gellerich FN,
Smeitink JA, Wieckowski MR, Willems PH, Koopman WJ. Mitochondrial dysfunction in primary human fibroblasts triggers an adaptive cell survival program that requires
AMPK-alpha. Biochimica et biophysica acta. 2015 Mar;1852(3):529-40.
Favretto ME, Brock R. Stereoselective Uptake of Cell-Penetrating Peptides is
Conserved in Antisense Oligonucleotide Polyplexes. Small. 2015 Mar;11(12):1414-7.
Forkink M, Willems PH, Koopman WJ, Grefte S. Live-cell assessment of mitochondrial reactive oxygen species using dihydroethidine. Methods Mol Biol. 2015;1264:161-9.
Holley RJ, Smith RA, van de Westerlo EM, Pickford CE, Merry CL, van Kuppevelt TH.
Use of flow cytometry for characterization and fractionation of cell populations based on their expression of heparan sulfate epitopes. Methods Mol Biol. 2015;1229:239-51.
Hoogenkamp HR, Bakker GJ, Wolf L, Suurs P, Dunnewind B, Barbut S, Friedl P, van
Kuppevelt TH, Daamen WF. Directing collagen fibers using counter-rotating cone extrusion. Acta Biomater. 2015 Jan;12:113-21.
Iida J, Dorchak J, Clancy R, Slavik J, Ellsworth R, Katagiri Y, Pugacheva EN, van
Kuppevelt TH, Mural RJ, Cutler ML, Shriver CD. Role for chondroitin sulfate

glycosaminoglycan in NEDD9-mediated breast cancer cell growth. Exp Cell Res. 2015
Jan 15;330(2):358-70.
Malmerberg E, PH MB-G, Katona G, Deupi X, Arnlund D, Wickstrand C, Johansson LC,
Westenhoff S, Nazarenko E, GF XS, Menzel A, de Grip WJ, Neutze R. Conformational activation of visual rhodopsin in native disc membranes. Sci Signal. 2015;8(367):ra26.
Moisan A, Lee YK, Zhang JD, Hudak CS, Meyer CA, Prummer M, Zoffmann S, Truong
HH, Ebeling M, Kiialainen A, Gerard R, Xia F, Schinzel RT, Amrein KE, Cowan CA.
White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell
Biol. 2015 Jan;17(1):57-67.
Ogren JI, Yi A, Mamaev S, Li H, Lugtenburg J, DeGrip WJ, Spudich JL, Rothschild KJ.
Comparison of the structural changes occurring during the primary phototransition of two different channelrhodopsins from Chlamydomonas algae. Biochemistry. 2015 Jan
20;54(2):377-88.
Pieterse E, Hofstra J, Berden J, Herrmann M, Dieker J, van der Vlag J. Acetylated histones contribute to the immunostimulatory potential of neutrophil extracellular traps in systemic lupus erythematosus. Clin Exp Immunol. 2015 Jan;179(1):68-74.
Theodoraki A, Hu Y, Poopalasundaram S, Oosterhof A, Guimond SE, Disterer P, Khoo
B, Hauge-Evans AC, Jones PM, Turnbull JE, van Kuppevelt TH, Bouloux PM. Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation. Mol Cell Endocrinol. 2015 Jan 5;399:296-310.
Venter G, Wijers M, Oerlemans FTJJ, Manjeri GR, Fransen JAM, Wieringa B. Glycolytic
Metabolism is Differentially Coupled to Proliferative Potential and Morphodynamic
Capacity in RAW 264.7 and Mafb/C-Maf Deficient Macrophage Lineages. an open access journal. [Research Article]. 2015 February 2, 2015:1-11.
Verdurmen WP, Luginbuhl M, Honegger A, Pluckthun A. Efficient cell-specific uptake of binding proteins into the cytoplasm through engineered modular transport systems. J
Control Release. 2015 Feb 28;200:13-22.
Witsenburg JJ, Sinzinger MD, Stoevesandt O, Ruttekolk IR, Roth G, Adjobo-Hermans
MJ, Brock R. A Peptide-functionalized polymer as a minimal scaffold protein to enhance cluster formation in early T cell signal transduction. Chembiochem : a European journal of chemical biology. 2015 Mar 2;16(4):602-10.
Adawy, A., W. Corbeek, E. A. Ronde de, W. J. Enckevort, W. J. Grip de and E. Vlieg
(2015). "Practical Kit for Micro-scale Applications of the Ceiling Crystallisation Method."
CrystEngComm 17: 2602-2605.
Adawy, A., E. G. Heijden van der, J. Hekelaar, W. J. Enckevort, W. J. Grip de and E.
Vlieg (2015

). "A. Comparative Study of Impurity Effects on Protein Crystallization: Diffusive versus
Convective Crystal Growth." Crystal Growth & Design 15: 1150-1159.
Alam, M. T., G. R. Manjeri, R. J. Rodenburg, J. A. Smeitink, R. A. Notebaart, M.
Huynen, P. H. Willems and W. J. Koopman (2015). "Skeletal muscle mitochondria of
NDUFS4(-/-) mice display normal maximal pyruvate oxidation and ATP production."
Biochim Biophys Acta 1847(6-7): 526-533.
Chaturvedi, V., D. E. Dye, B. F. Kinnear, T. H. van Kuppevelt, M. D. Grounds and D. R.
Coombe (2015). "Interactions between Skeletal Muscle Myoblasts and their
Extracellular Matrix Revealed by a Serum Free Culture System." PLoS One 10(6): e0127675.
Cluitmans, J. C., C. Tomelleri, Z. Yapici, S. Dinkla, P. Bovee-Geurts, V. Chokkalingam,
L. De Franceschi, R. Brock and G. J. Bosman (2015). "Abnormal red cell structure and function in neuroacanthocytosis." PLoS One 10(5): e0125580.
Dieker, J., L. Hilbrands, A. Thielen, H. Dijkman, J. H. Berden and J. van der Vlag
(2015). "Enhanced activation of dendritic cells by autologous apoptotic microvesicles in
MRL/lpr mice." Arthritis Res Ther 17(1): 103.
Favretto, M. E., A. Krieg, S. Schubert, U. S. Schubert and R. Brock (2015).
"Multifunctional poly(methacrylate) polyplex libraries: A platform for gene delivery inspired by nature." J Control Release 209: 1-11.
Ganapathy, S., O. Becheau, H. Venselaar, S. Frolich, J. B. van der Steen, Q. Chen, S.
Radwan, J. Lugtenburg, K. J. Hellingwerf, H. J. de Groot and W. J. de Grip (2015).
"Modulation of spectral properties and pump activity of proteorhodopsins by retinal analogues." Biochem J 467(2): 333-343.
Grefte, S., J. A. Wagenaars, R. Jansen, P. H. Willems and W. J. Koopman (2015).
"Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2." Biochim
Biophys Acta 1853(7): 1606-1614.
Iannetti, E. F., P. H. Willems, M. Pellegrini, J. Beyrath, J. A. Smeitink, L. Blanchet and
W. J. Koopman (2015). "Toward high-content screening of mitochondrial morphology and membrane potential in living cells." Int J Biochem Cell Biol 63: 66-70.
Malmerberg, E., M. B.-G. PH, G. Katona, X. Deupi, D. Arnlund, C. Wickstrand, L. C.
Johansson, S. Westenhoff, E. Nazarenko, G. F. Schertler, A. Menzel, W. J. de Grip and
R. Neutze (2015). "Conformational activation of visual rhodopsin in native disc membranes." Sci Signal 8(367): ra26.
Oh, S. K., J. I. Baek, K. M. Weigand, H. Venselaar, H. G. Swarts, S. H. Park, M. Hashim
Raza, J. Jung da, S. Y. Choi, S. H. Lee, T. Friedrich, G. Vriend, J. B. Koenderink, U. K.
Kim and K. Y. Lee (2015). "A missense variant of the ATP1A2 gene is associated with a

novel phenotype of progressive sensorineural hearing loss associated with migraine."
Eur J Hum Genet 23(5): 639-645.
Pot, M. W., K. A. Faraj, A. Adawy, W. J. van Enckevort, H. T. van Moerkerk, E. Vlieg,
W. F. Daamen and T. H. van Kuppevelt (2015). "Versatile wedge-based system for the construction of unidirectional collagen scaffolds by directional freezing: practical and theoretical considerations." ACS Appl Mater Interfaces 7(16): 8495-8505.
Renton, A. E., H. A. Pliner, C. Provenzano, A. Evoli, R. Ricciardi, M. A. Nalls, G.
Marangi, Y. Abramzon, S. Arepalli, S. Chong, D. G. Hernandez, J. O. Johnson, E.
Bartoccioni, F. Scuderi, M. Maestri, J. R. Gibbs, E. Errichiello, A. Chio, G. Restagno, M.
Sabatelli, M. Macek, S. W. Scholz, A. Corse, V. Chaudhry, M. Benatar, R. J. Barohn, A.
McVey, M. Pasnoor, M. M. Dimachkie, J. Rowin, J. Kissel, M. Freimer, H. J. Kaminski,
D. B. Sanders, B. Lipscomb, J. M. Massey, M. Chopra, J. F. Howard, Jr., W. J.
Koopman, M. W. Nicolle, R. M. Pascuzzi, A. Pestronk, C. Wulf, J. Florence, D.
Blackmore, A. Soloway, Z. Siddiqi, S. Muppidi, G. Wolfe, D. Richman, M. M. Mezei, T.
Jiwa, J. Oger, D. B. Drachman and B. J. Traynor (2015). "A genome-wide association study of myasthenia gravis." JAMA Neurol 72(4): 396-404.
Sepulveda-Diaz, J. E., S. M. Alavi Naini, M. B. Huynh, M. O. Ouidja, C. Yanicostas, S.
Chantepie, J. Villares, F. Lamari, E. Jospin, T. H. van Kuppevelt, A. G. Mensah-Nyagan,
R. Raisman-Vozari, N. Soussi-Yanicostas and D. Papy-Garcia (2015). "HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's diseaserelated tau pathology." Brain 138(Pt 5): 1339-1354.
Willems, P. H., J. Pahle, X. L. Stalpers, D. Mugahid, A. Nikolaew, W. J. Koopman and
U. Kummer (2015). "PKC-mediated inhibitory feedback of the cholecystokinin 1 receptor controls the shape of oscillatory Ca(2+) signals." Febs j 282(11): 2187-2201.
Adjobo-Hermans MJ, Cluitmans JC, Bosman GJ. Neuroacanthocytosis: Observations,
Theories and Perspectives on the Origin and Significance of Acanthocytes. Tremor
Other Hyperkinet Mov (N Y). 2015;5:328.
Baker GE, de Grip WJ, Turton M, Wagner HJ, Foster RG, Douglas RH. Light sensitivity in a vertebrate mechanoreceptor? J Exp Biol. 2015 Sep;218(Pt 18):2826-9.
Carvajal Monroy PL, Yablonka-Reuveni Z, Grefte S, Kuijpers-Jagtman AM, Wagener
FA, Von den Hoff JW. Isolation and Characterization of Satellite Cells from Rat Head
Branchiomeric Muscles. J Vis Exp. 2015(101):e52802.
Heidari-Hamedani G, Vives RR, Seffouh A, Afratis NA, Oosterhof A, van Kuppevelt TH,
Karamanos NK, Metintas M, Hjerpe A, Dobra K, Szatmari T. Syndecan-1 alters heparan sulfate composition and signaling pathways in malignant mesothelioma. Cell Signal.
2015 Oct;27(10):2054-67.

Lensen JF, van der Vlag J, Versteeg EM, Wetzels JF, van den Heuvel LP, Berden JH, van Kuppevelt TH, Rops AL. Differential Expression of Specific Dermatan Sulfate
Domains in Renal Pathology. PLoS One. 2015;10(9):e0134946.
Liemburg-Apers DC, Willems PH, Koopman WJ, Grefte S. Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism. Arch Toxicol.
2015 Aug;89(8):1209-26.
Schirris TJ, Renkema GH, Ritschel T, Voermans NC, Bilos A, van Engelen BG, Brandt
U, Koopman WJ, Beyrath JD, Rodenburg RJ, Willems PH, Smeitink JA, Russel FG.
Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition. Cell
Metab. 2015 Sep 1;22(3):399-407.
Schmidt S, Wallbrecher R, van Kuppevelt TH, Brock R. Methods to Study the Role of the Glycocalyx in the Uptake of Cell-Penetrating Peptides. Methods Mol Biol.
2015;1324:123-31.
Shirzad-Wasei N, van Oostrum J, Bovee-Geurts PH, Kusters LJ, Bosman GJ, DeGrip
J. Rapid transfer of overexpressed integral membrane protein from the host membrane into soluble lipid nanodiscs without previous purification. Biol Chem. 2015
Aug;396(8):903-15.
Sieprath T, Corne TD, Nooteboom M, Grootaert C, Rajkovic A, Buysschaert B, Robijns
J, Broers JL, Ramaekers FC, Koopman WJ, Willems PH, De Vos WH. Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates. Nucleus. 2015;6(3):236-46. van Bracht E, Raave R, Perevyazko IY, Versteeg EM, Hafmans TG, Schubert US,
Oosterwijk E, van Kuppevelt TH, Daamen WF. Biodistribution of size-selected lyophilisomes in mice. Eur J Pharm Biopharm. 2015 Aug;94:141-51. van Unen J, Woolard J, Rinken A, Hoffmann C, Hill SJ, Goedhart J, Bruchas MR
Bouvier M, Adjobo-Hermans MJ. A Perspective on Studying G-Protein-Coupled
Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms.
Mol Pharmacol. 2015 Sep;88(3):589-95. van Wijk XM, Lawrence R, Thijssen VL, van den Broek SA, Troost R, van Scherpenzee l M, Naidu N, Oosterhof A, Griffioen AW, Lefeber DJ, van Delft FL, van Kuppevelt TH. A common sugar-nucleotide-mediated mechanism of inhibition of (glycosamino)glycan biosynthesis, as evidenced by 6F-GalNAc (Ac3). FASEB J. 2015 Jul;29(7):2993-3002.
Willems PH, Rossignol R, Dieteren CE, Murphy MP, Koopman WJ. Redox Homeostasis and Mitochondrial Dynamics. Cell Metab. 2015 Aug 4;22(2):207-18.