1
CURRICULUM VITAE
DAVID DUNBAR IVY, M.D.
Current Position
Professor of Pediatrics
Chief of Pediatric Cardiology
University of Colorado School of Medicine
Professional Address
Pediatric Cardiology
Children's Hospital Colorado
13123 East 16th Avenue
Box B100
Aurora, Colorado 80045
Phone: 720-777-3367
Fax: 720-777-7290
Education
Davidson College, Davidson, NC
BS in Biology, cum laude
1980-1984
Tulane University School of Medicine, New Orleans, LA
MD
1984-1988
University of Colorado Health Sciences Center, Denver, CO 1988-1991
Pediatrics
University of Colorado Health Sciences Center, Denver, CO 1991-1994
Pediatric Cardiology Fellowship
Licensure
Colorado State Board of Medical Examiners. License #31436
Board Certification
FLEX
Pediatrics
Pediatric Cardiology
June, 1988
#219149
#219149
Academic Appointments and Employment
Instructor of Pediatrics, UCDHSC
Assistant Professor of Pediatrics, UCDHSC
Associate Professor of Pediatrics, UCDHSC
Professor of Pediatrics, UCDHSC
Award of Tenure, UCDHSC
1994-1996
1996-2001
2001-2007
2007 -present
2007-present
2
Honors /Awards
Fellows Basic Research Award
The Society For Pediatric Research
Research paper 1st place
Frontiers in Cardiology
Children’s Choice Award
Pulmonary Hypertension Program
Selby’s Endowed Chair of Pediatric Cardiology
Scientific Leadership Council
Pulmonary Hypertension Association
5280 Magazine Top Docs
Heart Who Cares Award- CHHI
Patient Perception Award / Overall Top Performer
PRC National Excellence in Healthcare Awards
Board of Trustees
Pulmonary Hypertension Association
Board of Trustees
Pediatric Congenital Heart Association
1993
1995
2001
2003 - present
2005-2013
2005-2008,
2010-2014
2008
2011-2012
2011-2014
2014 - present
Society Memberships
American College of Cardiology, Fellow
American Academy of Pediatrics, Fellow
American College of Chest Physicians, Fellow
American Heart Association, Cardiovascular Disease in the Young
Pediatric Cardiac Intensive Care Society
Pulmonary Hypertension Association
American Physiological Society
Society For Pediatric Research
Association for European Paediatric Cardiology
Pulmonary Vascular Research Institute
Institutional Committees
Blood Utilization Review Committee, TCH
1999-2000
Search Committee, Cardiac ICU Director, TCH
1999-2002
Graduate Medical Education
2001
Internal review of Nuclear Medicine and Cardiac Electrophysiology
Nominating Committee for The Children’s Hospital,
2000-2002
Imagine the Miracles, The Children’s Hospital Foundation
2003-2004
Search Committee, Chief Adult Cardiology, UCDHSC
2005-2006
Data Safety and Monitoring Board: “Effect of Statin Therapy 2010-2012
on Disease Progression in Children with ADPKD”,
Melissa Cadnapaphornchai, M.D., PI
3
National Committees / Reviews
NICHD Supplemental U01 Grants
Society for Pediatric Research
Young Investigator Award Committee
American College of Cardiology, abstract reviewer
Society of Pediatric Research, abstract reviewer
NIH NHLBI Loan Repayment Program L30
Gilead Research Scholars Grant Review Board
Guidelines for Pediatric Cardiology Training Programs
Pulmonary Hypertension Academic Research Consortium
NIH Workshop: Improving Outcomes in
Pulmonary Hypertension
Gilead Sciences Research Scholars Program Grant
Review Committee
American Heart Association, National Program Planning
Committee
Cardiovascular Medical Research and Education Fund
Program Grant Review Committee
Congressionally Directed Medical Research Program
Department of Defense grant Reviewer
Local Committees
Executive Planning Committee, Denver American
Heart Association Heart Ball
Journal Review Boards
Circulation
Journal of the American College of Cardiology
American Journal of Cardiology
American Journal of Physiology
British Journal of Pharmacology
Biology of the Neonate
Biology of Perinatal Medicine
Critical Care Medicine
Pediatric Pulmonology
Catheterization and Cardiovascular Diagnosis
Pediatric Research
Annals of Thoracic Surgery
American Journal of Respiratory and Critical Care Medicine
Journal of Pediatrics
Pediatrics
European Respiratory Journal
Journal of Applied Physiology
Circulation Journal Japan
Journal of Infection and Public Health
Chest
Journal of Critical Care
Advances in Pulmonary Hypertension
American Journal of Cardiovascular Drugs
2004
2005-2008
2006, 2011
2007
2009-2010
2009-2010
201020102011
2010-2012
2011-2013
2012
2013
2011-2013
4
Editorial Board
American Thoracic Society
Topic Editor, Pulmonary Circulation Journal Club
Congenital Heart Disease:
Clinical Studies from Fetus to Adulthood
Advances in Pulmonary Hypertension
Pulmonary Hypertension Association
Frontiers in Cardiology
2002-2004
2005 to present
2011 to present
2011 to present
Grant Support
American Heart Association Fellowship Award
1993-1994
Title: Role of Endothelin in Perinatal Pulmonary Hypertension
Source/Identifying No: American Heart Association of Colorado
(CF-035-93)
Role on Project:
PI
Effort:
75%
Bugher Physician Scientist Training Program
1994-1996
Title: Endothelin in the Perinatal Pulmonary Circulation
Source/Identifying No: Bugher Physician Scientist Training Program
Role on Project:
PI
Effort:
75%
Clinical Research Center, The Children’s Hospital of Denver
1995-1997
Title: Use of Intravascular Ultrasound in Pediatric Pulmonary Hypertension
Source/Identifying No.: Clinical Research Center
Role on Project:
PI
Effort:
75%
Children’s Hospital Research Institute Career Development Award
1996-1998
Title: Endothelin in the Perinatal Pulmonary Circulation
Source/Identifying No.: The Children’s Hospital Research Institute
Role on Project:
PI
Effort:
75%
March of Dimes Basil O’Connor Starter Scholar Award
1997-1999
Title: Role of Endothelin in Perinatal Pulmonary Hypertension
Source/Identifying No.: March of Dimes
Role on Project:
PI
Effort:
75%
American Heart Association
1999-2001
Title: Role of the Endothelin B Receptor in a Model of Pulmonary
Hypertension
Source/Identifying No.: AHA, Desert / Mountain Affiliate (9951441Z)
Role on Project:
PI
Effort:
75%
5
K08 Physician Scientist Award
1999-2003
Title: Role of Endothelin in Perinatal Pulmonary Vasoregulation
Source/Identifying No.: NIH / NHLBI (K08 HL03823)
Role on Project:
PI
Effort:
75%
R01 National Institutes of Health
2001-2006
Title: Noninvasive Assessment of Pediatric Pulmonary Hypertension
Source/Identifying No.: NIH / NHLBI (R01 HL067393)
Role on Project: Collaborating Investigator
PI on Grant: Robin Shandas, PhD
Effort:
5%
R38 US Department of Health and Human Services
2003-2006
Title: Infant Heart Transplantation from Non-Heart-Beating Donors: A
Strategy to Reduce Waiting Mortality
Source/Identifying No.: USDHHS (R38 OT0Role on Project: Collaborating
Investigator
PI on Grant:
Mark Boucek, MD
Effort:
10%
U01 NIH/NHLBI Clinical Proteomics Programs
Title: Clinical Proteomics Program in Lung Disease
Source/Identifying No.: NIH / NHLBI (U01 HL081335)
Role on Project: Collaborating Investigator
PI on Grant: Frank Accurso, MD
Effort:
3%
2005-2009
National Institutes of Health
2006-2009
Title: Sildenafil in Treatment of Sickle Cell Disease Associated
Pulmonary Hypertension
Source/Identifying No: NIH / NHLBI (HHSN268200617185C)
Role on Project: Collaborating Investigator
PI on Grant:
David Badesch, MD
Effort:
3%
RC1 National Institutes of Health / NHLBI ARRA Challenge Grant
2009-2011
Title: Identification and validation of quantifiable biomarkers of vasodilator
therapeutic response in children with IPAH
Source/Identifying No: NIH / NHLBI (RC1HL099786)
Role on Project: Collaborating Investigator
PI on Grant:
Allan Everett, MD
Effort:
5%
6
P50 Specialized Centers of Clinically Oriented Research (SCCOR)
2006-2011
Title: Lung Vascular Disease in Infants and Children: Mechanisms and
Treatment
Source/Identifying No: NIH/NHLBI (P50 HL084923)
Role on Project: CO-PI (Shandas) Module 3
PI on Grant:
Kurt Stenmark, MD
Effort:
10%
R01 National Institutes of Health
2012-2017
Title: Functional and Biological Phenotyping of Pediatric Pulmonary
Hypertension
Source/Identifying No.: NIH / NHLBI (R01 HL114753)
Role on Project: Collaborating Investigator
PI on Grant: Robin Shandas, PhD
Effort:
10%
R24 National Institutes of Health
2012-2017
Title: National Biological Sample and Data Repository for PAH
Source/Identifying No.: NIH / NHLBI (R24 HL105333)
Role on Project: Collaborating Investigator
PI on Grant: Bill Nichols, MD
Effort:
5%
U01 National Institutes of Health
2014-2018
Title: Data Fusion: A Sustainable, Scalable, Open Source Registry
Advancing Pulmonary Vascular Disease Research
Source/Identifying No.: NIH / NHLBI (U01HL121518)
Role on Project: Collaborating Investigator
PI on Grant: Steve Abman / Mandl MD
Effort:
13%
Major Scientific Interests
Pulmonary Hypertension
Pulmonary hypertension secondary to congenital heart disease
Evaluation of pulmonary hypertension by echo
Pulmonary Vascular Biology
Endothelin
Nitric Oxide
Fetal Circulation
Regulation of fetal pulmonary blood flow
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Bibliography
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disorders through patient registries. Am J Respir Crit Care Med. 2015 Jan
1;191(1):2-4. PMID: 25551339
2. Jone P, Ivy DD. Echocardiography in pediatric pulmonary hypertension.
Front Pediatr. 2014 Nov 12;2:124. PMID: 25429362
3. Nies MK, Ivy DD, Everett AD. The untapped potential of proteomic
analysis in pediatric pulmonary hypertension. Proteomics Clin Appl. 2014
Oct 28. PMID: 25348110
4. Nicolarsen J, Ivy D. Progress in the diagnosis and management of
pulmonary hypertension in children. Curr Opin Pediatr. 2014
Oct;26(5):527-35. PMID: 25136947
5. Lopes AA, Barst RJ, Haworth SG, Rabinovitch M, Al Dabbagh M, Del
Cerro MJ, Ivy D, Kashour T, Kumar K, Harikrishnan S, et al. Repair of
congenital heart disease with associated pulmonary hypertension in
children: what are the minimal investigative procedures? Consensus
statement from the Congenital Heart Disease and Pediatric Task Forces,
Pulmonary Vascular Research Institute (PVRI). Pulm Circ. 2014
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6. Di Maria MV, Younoszai AK, Mertens L, Landeck BF 2nd, Ivy DD, Hunter
KS, Friedberg MK. RV stroke work in children with pulmonary arterial
hypertension: estimation based on invasive haemodynamic assessment
and correlation with outcomes. Heart. 2014 Sep;100(17):1342-7 PubMed
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7. Zijlstra WM, Douwes JM, Rosenzweig EB, Schokker S, Krishnan U,
Roofthooft MT, Miller-Reed K, Hillege HL, Ivy DD, Berger RM. Survival
differences in pediatric pulmonary arterial hypertension: clues to a better
understanding of outcome and optimal treatment strategies. J Am Coll
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8. Colvin KL, Dufva MJ, Delaney RP, Ivy DD, Stenmark KR, Yeager ME.
Biomarkers for Pediatric Pulmonary Arterial Hypertension - A Call to
Collaborate. Front Pediatr. 2014 Feb 3;2:7. PubMed PMID: 24551834
9. Barst RJ, Beghetti M, Pulido T, Layton G, Konourina I, Richardson H, Ivy
DD, and the STARTS-2 Investigators. STARTS-2: Long-Term Survival
With Oral Sildenafil Monotherapy in Treatment-Naïve Pediatric Pulmonary
Arterial Hypertension. Circulation 2014;129(19):1914-1923 PubMed
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10. Jone PN, Hinzman J, Wagner BD, Ivy DD, Younoszai A. Right Ventricular
to Left Ventricular Diameter Ratio at End-Systole in Evaluating Outcomes
in Children with Pulmonary Hypertension. J Am Soc Echocardiogr. 2014
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11. Barst RJ, Ivy DD, Foreman AJ, McGoon MD, Rosenzweig EB. Four- and
Seven-Year Outcomes of Patients With Congenital Heart DiseaseAssociated Pulmonary Arterial Hypertension (from the REVEAL Registry).
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12. Vorhies EE, Ivy DD. Drug Treatment of Pulmonary Hypertension in
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SG, Raj JU, Rosenzweig EB, Schulze Neick I, Steinhorn RH, Beghetti M.
Pediatric Pulmonary Hypertension. J Am Coll Cardiol. 2013 Dec 24;62(25
Suppl):D117-26. PMID: 24355636
Rausch CM, Taylor AL, Ross H, Sillau S, Ivy DD. Ventilatory efficiency
slope correlates with functional capacity, outcomes, and disease severity
in pediatric patients with pulmonary hypertension. Int J Cardiol. 2013 Nov
30;169(6):445-8. PubMed PMID: 24144928.
Wagner BD, Takatsuki S, Accurso FJ, Ivy DD. Evaluation of circulating
proteins and hemodynamics towards predicting mortality in children with
pulmonary arterial hypertension. PLoS One. 2013 Nov 20;8(11):e80235.
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Colvin KL, Cripe PJ, Ivy DD, Stenmark KR, Yeager ME. Bronchusassociated Lymphoid Tissue in Pulmonary Hypertension Produces
Pathologic Autoantibodies. Am J Respir Crit Care Med. 2013 Nov
1;188(9):1126-36. PubMed PMID: 24093638.
Zhou Z, Malhotra SP, Yu X, Rutledge J, Rebeyka IM, Ross DB, Rausch C,
Gu H, McCrindle B, Lacour-Gayet F, Ivy D, Li J. Moderate altitude is not
associated with adverse postoperative outcomes for patients undergoing
bidirectional cavopulmonary anastomosis and Fontan operation: a
comparative study among Denver, Edmonton, and Toronto. J Thorac
Cardiovasc Surg. 2013 Nov;146(5):1165-71. PubMed PMID: 23353110;
PubMed Central PMCID: PMC3800264.
Takatsuki S, Ivy DD. Current challenges in pediatric pulmonary
hypertension. Semin Respir Crit Care Med. 2013 Oct;34(5):627-44.
PubMed PMID: 24037630.
Friesen RH, Nichols CS, Twite MD, Cardwell KA, Pan Z, Pietra B,
Miyamoto SD, Auerbach SR, Darst JR, Ivy DD. The hemodynamic
response to dexmedetomidine loading dose in children with and without
pulmonary hypertension. Anesth Analg. 2013 Oct;117(4):953-9. PubMed
PMID: 23960035; PubMed Central PMCID: PMC3830564.
Maxey DM, Ivy DD, Ogawa MT, Feinstein JA. Food and Drug
Administration (FDA) postmarket reported side effects and adverse events
associated with pulmonary hypertension therapy in pediatric patients.
Pediatr Cardiol. 2013 Oct;34(7):1628-36. PubMed PMID: 23532466;
PubMed Central PMCID: PMC3783558.
Truong U, Fonseca B, Dunning J, Burgett S, Lanning C, Ivy DD, Shandas
R, Hunter K, Barker AJ. Wall shear stress measured by phase contrast
cardiovascular magnetic resonance in children and adolescents with
pulmonary arterial hypertension. J Cardiovasc Magn Reson. 2013 Sep
13;15(1):81. PubMed PMID: 24034144.
Beghetti M, Berger RM, Schulze-Neick I, Day RW, Pulido T, Feinstein J,
Barst RJ, Humpl T; TOPP Registry Investigators. Diagnostic evaluation of
paediatric pulmonary hypertension in current clinical practice. Eur Respir
J. 2013 Sep;42(3):689-700. PubMed PMID: 23563261.
Wessel DL, Berger F, Li JS, Dahnert I, Rakhit A, Fontecave S, Newburger
JW; CLARINET Investigators. Clopidogrel in infants with systemic-topulmonary-artery shunts. N Engl J Med. 2013 Jun 20;368(25):2377-84.
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PubMed PMID: 23782178.
Siehr SL, Ivy DD, Miller-Reed K, Ogawa M, Rosenthal DN, Feinstein JA.
Children with pulmonary arterial hypertension and prostanoid therapy:
long-term hemodynamics. J Heart Lung Transplant. 2013 May;32(5):54652. PubMed PMID: 23453572; PubMed Central PMCID: PMC3760159.
Takatsuki S, Parker DK, Doran AK, Friesen RH, Ivy DD. Acute pulmonary
vasodilator testing with inhaled treprostinil in children with pulmonary
arterial hypertension. Pediatr Cardiol. 2013 Apr;34(4):1006-12. PubMed
PMID: 23184020; PubMed Central PMCID: PMC3608847.
Adatia I, Haworth SG, Wegner M, Barst RJ, Ivy D, Stenmark KR,
Karkowsky A, Rosenzweig E, Aguilar C. Clinical trials in neonates and
children: Report of the pulmonary hypertension academic research
consortium pediatric advisory committee. Pulm Circ. 2013 Jan;3(1):25266. PubMed PMID: 23662203; PubMed Central PMCID: PMC3641736.
Grieve AP, Chow SC, Curram J, Dawe S, Harnisch LO, Henig NR, Hung
HM, Ivy DD, Kawut SM, Rahbar MH, Xiao S, Wilkins MR. Advancing
clinical trial design in pulmonary hypertension. Pulm Circ. 2013
Jan;3(1):217-25. PubMed PMID: 23662200; PubMed Central PMCID:
PMC3641733.
Takatsuki S, Rosenzweig EB, Zuckerman W, Brady D, Calderbank M, Ivy
DD. Clinical safety, pharmacokinetics, and efficacy of ambrisentan
therapy in children with pulmonary arterial hypertension. Pediatr
Pulmonol. 2013 Jan;48(1):27-34. PubMed PMID: 22511577; PubMed
Central PMCID: PMC3412194.
Krishnan U, Takatsuki S, Ivy DD, Kerstein J, Calderbank M, Coleman E,
Rosenzweig EB. Effectiveness and safety of inhaled treprostinil for the
treatment of pulmonary arterial hypertension in children. Am J Cardiol.
2012 Dec 1;110(11):1704-9. PubMed PMID: 22917554; PubMed Central
PMCID: PMC3508003.
Takatsuki S, Nakayama T, Jone PN, Wagner BD, Naoi K, Ivy DD, Saji T.
Tissue Doppler imaging predicts adverse outcome in children with
idiopathic pulmonary arterial hypertension. J Pediatr. 2012
Dec;161(6):1126-31. PubMed PMID: 22748515; PubMed Central PMCID:
PMC3508005.
Yeager ME, Colvin KL, Everett AD, Stenmark KR, Ivy DD. Plasma
proteomics of differential outcome to long-term therapy in children with
idiopathic pulmonary arterial hypertension. Proteomics Clin Appl. 2012
Jun;6(5-6):257-67. PubMed PMID: 22653875; PubMed Central PMCID:
PMC3569520.
Takatsuki S, Darst JR, Das BB, Fagan TE, Wolfe R, Ivy DD. Clinical
manifestations and long-term follow-up in pediatric patients living at
altitude with isolated pulmonary artery of ductal origin. Pediatr Cardiol.
2012 Jun;33(5):775-81. PubMed PMID: 22430374; PubMed Central
PMCID: PMC3360790.
Takatsuki S, Calderbank M, Ivy DD. Initial experience with tadalafil in
pediatric pulmonary arterial hypertension. Pediatr Cardiol. 2012
Jun;33(5):683-8. PubMed PMID: 22402804; PubMed Central PMCID:
PMC3366091.
Stoica S, Carpenter E, Campbell D, Mitchell M, da Cruz E, Ivy D, Lacour-
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Gayet F. Morbidity of the arterial switch operation. Ann Thorac Surg. 2012
Jun;93(6):1977-83. PubMed PMID: 22365263; PubMed Central PMCID:
PMC3381339.
Takatsuki S, Wagner BD, Ivy DD. B-type natriuretic peptide and aminoterminal pro-B-type natriuretic peptide in pediatric patients with pulmonary
arterial hypertension. Congenit Heart Dis. 2012 May-Jun;7(3):259-67.
PubMed PMID: 22325151; PubMed Central PMCID: PMC3355223.
Yeager ME, Nguyen CM, Belchenko DD, Colvin KL, Takatsuki S, Ivy DD,
Stenmark KR. Circulating myeloid-derived suppressor cells are increased
and activated in pulmonary hypertension. Chest. 2012 Apr;141(4):944-52.
PubMed PMID: 21940769; PubMed Central PMCID: PMC3318947.
Yeager ME, Reddy MB, Nguyen CM, Colvin KL, Ivy DD, Stenmark KR.
Activation of the unfolded protein response is associated with pulmonary
hypertension. Pulm Circ. 2012 Apr-Jun;2(2):229-40. PubMed PMID:
22837864; PubMed Central PMCID: PMC3401877.
Barst RJ, Channick R, Ivy D, Goldstein B. Clinical perspectives with longterm pulsed inhaled nitric oxide for the treatment of pulmonary arterial
hypertension. Pulm Circ. 2012 Apr-Jun;2(2):139-47. PubMed PMID:
22837854; PubMed Central PMCID: PMC3401867.
Takatsuki S, Ivy DD, Nuss R. Correlation of N-terminal fragment of B-type
natriuretic peptide levels with clinical, laboratory, and echocardiographic
abnormalities in children with sickle cell disease. J Pediatr. 2012
Mar;160(3):428-433.e1. PubMed PMID: 22048047; PubMed Central
PMCID: PMC3274616.
Ivy D. Advances in pediatric pulmonary arterial hypertension. Curr Opin
Cardiol. 2012 Mar;27(2):70-81. PubMed PMID: 22274573; PubMed
Central PMCID: PMC3319159.
Berger RM, Beghetti M, Humpl T, Raskob GE, Ivy DD, Jing ZC, Bonnet D,
Schulze-Neick I, Barst RJ. Clinical features of paediatric pulmonary
hypertension: a registry study. Lancet. 2012 Feb 11;379(9815):537-46.
PubMed PMID: 22240409; PubMed Central PMCID: PMC3426911.
Barst RJ, Ivy DD, Gaitan G, Szatmari A, Rudzinski A, Garcia AE, Sastry
BK, Pulido T, Layton GR, Serdarevic-Pehar M, Wessel DL. A randomized,
double-blind, placebo-controlled, dose-ranging study of oral sildenafil
citrate in treatment-naive children with pulmonary arterial hypertension.
Circulation. 2012 Jan 17;125(2):324-34. PubMed PMID: 22128226.
Barst RJ, McGoon MD, Elliott CG, Foreman AJ, Miller DP, Ivy DD.
Survival in childhood pulmonary arterial hypertension: insights from the
registry to evaluate early and long-term pulmonary arterial hypertension
disease management. Circulation. 2012 Jan 3;125(1):113-22. PubMed
PMID: 22086881.
Feinstein JA, Benson DW, Dubin AM, Cohen MS, Maxey DM, Mahle WT,
Pahl E, Villafañe J, Bhatt AB, Peng LF, Johnson BA, Marsden AL,
Daniels CJ, Rudd NA, Caldarone CA, Mussatto KA, Morales DL, Ivy DD,
Gaynor JW, Tweddell JS, Deal BJ, Furck AK, Rosenthal GL, Ohye RG,
Ghanayem NS, Cheatham JP, Tworetzky W, Martin GR. Hypoplastic left
heart syndrome: current considerations and expectations. J Am Coll
Cardiol. 2012 Jan 3;59(1 Suppl):S1-42. PubMed PMID: 22192720.
Yeager ME, Belchenko DD, Nguyen CM, Colvin KL, Ivy DD, Stenmark KR.
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Endothelin-1, the unfolded protein response, and persistent inflammation:
role of pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol.
2012 Jan;46(1):14-22. PubMed PMID: 21778413; PubMed Central
PMCID: PMC3262656.
Yeager ME, Nguyen CM, Belchenko DD, Colvin KL, Takatsuki S, Ivy DD,
Stenmark KR. Circulating fibrocytes are increased in children and young
adults with pulmonary hypertension. Eur Respir J. 2012 Jan;39(1):104-11.
PubMed PMID: 21700605; PubMed Central PMCID: PMC3319160.
Duncan M, Wagner BD, Murray K, Allen J, Colvin K, Accurso FJ, Ivy DD.
Circulating cytokines and growth factors in pediatric pulmonary
hypertension. Mediators Inflamm. 2012;2012:143428. PubMed PMID:
23316102; PubMed Central PMCID: PMC3536060.
Law YM, Mack CL, Sokol RJ, Rice M, Parsley L, Ivy D. Cardiopulmonary
manifestations of portovenous shunts from congenital absence of the
portal vein: pulmonary hypertension and pulmonary vascular dilatation.
Pediatr Transplant. 2011 Dec;15(8):E162-8. PubMed PMID: 20565694;
PubMed Central PMCID: PMC3203339.
Lammers AE, Adatia I, Cerro MJ, Diaz G, Freudenthal AH, Freudenthal F,
Harikrishnan S, Ivy D, Lopes AA, Raj JU, Sandoval J, Stenmark K,
Haworth SG. Functional classification of pulmonary hypertension in
children: Report from the PVRI pediatric taskforce, Panama 2011. Pulm
Circ. 2011 Aug 2;1(2):280-285. PubMed PMID: 21874157; PubMed
Central PMCID: PMC3161406.
Takatsuki S, Soep JB, Calderbank M, Ivy DD. Connective tissue disease
presenting with signs and symptoms of pulmonary hypertension in
children. Pediatr Cardiol. 2011 Aug;32(6):828-33. PubMed PMID:
21448619; PubMed Central PMCID: PMC3142789.
Abman SH, Ivy DD. Recent progress in understanding pediatric
pulmonary hypertension. Curr Opin Pediatr. 2011 Jun;23(3):298-304.
PubMed PMID: 21572384; PubMed Central PMCID: PMC3128451.
Mallory GB Jr, Hanna BD, Ivy DD, Shardonofsky F, Farber HJ.
Management and Controversies in Pediatric Pulmonary Hypertension.
Pediatr Allergy Immunol Pulmonol. 2011 Mar 4;22(4):139-150. PubMed
PMID: 21766047; PubMed Central PMCID: PMC3136886.
Barst RJ, Ertel SI, Beghetti M, Ivy DD. Pulmonary arterial hypertension: a
comparison between children and adults. Eur Respir J. 2011
Mar;37(3):665-77. PubMed PMID: 21357924; PubMed Central PMCID:
PMC3128436.
Olin J, Abman S, Grady R, Ivy D, Lovell M, Partrick D, Balasubramaniam
V. A 7-year-old with pulmonary hypertension. BMJ Case Rep.
2011;2011:bcr0220113843. PubMed PMID: 21897452; PubMed Central
PMCID: PMC3082056.
Cerro MJ, Abman S, Diaz G, Freudenthal AH, Freudenthal F, Harikrishnan
S, Haworth SG, Ivy D, Lopes AA, Raj JU, Sandoval J, Stenmark K, Adatia
I. A consensus approach to the classification of pediatric pulmonary
hypertensive vascular disease: Report from the PVRI Pediatric Taskforce,
Panama 2011. Pulm Circ. 2011;1(2):286-298. PubMed PMID: 21874158;
PubMed Central PMCID: PMC3161725.
Phelps CM, Tissot C, Buckvold S, Gralla J, Ivy DD, Pietra BA, Miyamoto
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SD. Outcome of acute graft rejection associated with hemodynamic
compromise in pediatric heart transplant recipients. Pediatr Cardiol. 2011
Jan;32(1):1-7. PubMed PMID: 20963408; PubMed Central PMCID:
PMC3120936.
Hunter KS, Feinstein JA, Ivy DD, Shandas R. Computational Simulation of
the Pulmonary Arteries and its Role in the Study of Pediatric Pulmonary
Hypertension. Prog Pediatr Cardiol. 2010 Dec 1;30(1-2):63-69. PubMed
PMID: 21499523; PubMed Central PMCID: PMC3076725.
Hill KD, Lim DS, Everett AD, Ivy DD, Moore JD. Assessment of pulmonary
hypertension in the pediatric catheterization laboratory: current insights
from the Magic registry. Catheter Cardiovasc Interv. 2010 Nov
15;76(6):865-73. PubMed PMID: 20549685; PubMed Central PMCID:
PMC3116922.
Ivy DD, Rosenzweig EB, Lemarie JC, Brand M, Rosenberg D, Barst RJ.
Long-term outcomes in children with pulmonary arterial hypertension
treated with bosentan in real-world clinical settings. Am J Cardiol. 2010
Nov 1;106(9):1332-8. PubMed PMID: 21029834; PubMed Central PMCID:
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Tissot C, Ivy DD, Beghetti M. Medical therapy for pediatric pulmonary
arterial hypertension. J Pediatr. 2010 Oct;157(4):528-32. PubMed PMID:
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Ivy D, Saji BT. A New Era in Medical Management of Severe Pediatric
Pulmonary Arterial Hypertension. Nihon Shoni Junkanki Gakkai Zasshi.
2010 Jun 4;26(3):206-218. PubMed PMID: 23264720; PubMed Central
PMCID: PMC3527842.
Tian L, Hunter KS, Kirby KS, Ivy DD, Shandas R. Measurement
uncertainty in pulmonary vascular input impedance and characteristic
impedance estimated from pulsed-wave Doppler ultrasound and pressure:
clinical studies on 57 pediatric patients. Physiol Meas. 2010
Jun;31(6):729-48. PubMed PMID: 20410558; PubMed Central PMCID:
PMC3010409.
Ivy DD. Prostacyclin in the intensive care setting. Pediatr Crit Care Med.
2010 Mar;11(2 Suppl):S41-5. PubMed PMID: 20216163; PubMed Central
PMCID: PMC3116926.
Ye M, Coldren C, Liang X, Mattina T, Goldmuntz E, Benson DW, Ivy D,
Perryman MB, Garrett-Sinha LA, Grossfeld P. Deletion of ETS-1, a gene
in the Jacobsen syndrome critical region, causes ventricular septal
defects and abnormal ventricular morphology in mice. Hum Mol Genet.
2010 Feb 15;19(4):648-56. PMID: 19942620; PubMed Central PMCID:
PMC2807373.
Ivy DD, Feinstein JA, Humpl T, Rosenzweig EB. Non-congenital heart
disease associated pediatric pulmonary arterial hypertension. Prog
Pediatr Cardiol. 2009 Dec 1;27(1-2):13-23. PubMed PMID: 21852894;
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Rosenzweig EB, Feinstein JA, Humpl T, Ivy DD. Pulmonary arterial
hypertension in children: Diagnostic work-up and challenges. Prog Pediatr
Cardiol. 2009 Dec;27(1):4-11. PubMed PMID: 21691442; PubMed Central
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Jais X, Schulze-Neick I, Galie N, Morganti A, Dingemanse J, Kusic-Pajic
A, Berger RM. Pharmacokinetic and clinical profile of a novel formulation
of bosentan in children with pulmonary arterial hypertension: the
FUTURE-1 study. Br J Clin Pharmacol. 2009 Dec;68(6):948-55. PubMed
PMID: 20002090; PubMed Central PMCID: PMC2805863.
Whitworth JR, Ivy DD, Gralla J, Narkewicz MR, Sokol RJ. Pulmonary
vascular complications in asymptomatic children with portal hypertension.
J Pediatr Gastroenterol Nutr. 2009 Nov;49(5):607-12. PubMed PMID:
19820411; PubMed Central PMCID: PMC2783348.
Ivy DD, Calderbank M, Wagner BD, Dolan S, Nyquist AC, Wade M,
Nickels WM, Doran AK. Closed-hub systems with protected connections
and the reduction of risk of catheter-related bloodstream infection in
pediatric patients receiving intravenous prostanoid therapy for pulmonary
hypertension. Infect Control Hosp Epidemiol. 2009 Sep;30(9):823-9.
PubMed PMID: 19637961; PubMed Central PMCID: PMC3117306.
Tissot C, Buckvold S, Phelps CM, Ivy DD, Campbell DN, Mitchell MB, da
Cruz SO, Pietra BA, Miyamoto SD. Outcome of extracorporeal membrane
oxygenation for early primary graft failure after pediatric heart
transplantation. J Am Coll Cardiol. 2009 Aug 18;54(8):730-7. PubMed
PMID: 19679252; PubMed Central PMCID: PMC3117294.
Miyamoto SD, Pietra BA, Chan KC, Ivy DD, Mashburn C, Campbell DN,
Mitchell MB, Boucek MM. Long-term outcome of palliation with internal
pulmonary artery bands after primary heart transplantation for hypoplastic
left heart syndrome. Pediatr Cardiol. 2009 May;30(4):419-25. PubMed
PMID: 19365660; PubMed Central PMCID: PMC3117302.
Morchi GS, Ivy DD, Duster MC, Claussen L, Chan KC, Kay J. Sildenafil
Increases Systemic Saturation and Reduces Pulmonary Artery Pressure
in Patients with Failing Fontan Physiology. Congenit Heart Dis. 2009
Apr;4(2):107-111. PubMed PMID: 21866231; PubMed Central PMCID:
PMC3159127.
Goldberg SP, McCanta AC, Campbell DN, Carpenter EV, Clarke DR, da
Cruz E, Ivy DD, Lacour-Gayet FG. Implications of incising the ventricular
septum in double outlet right ventricle and in the Ross-Konno operation.
Eur J Cardiothorac Surg. 2009 Apr;35(4):589-93. PubMed PMID:
19269838; PubMed Central PMCID: PMC3117298.
Coldren CD, Lai Z, Shragg P, Rossi E, Glidewell SC, Zuffardi O, Mattina
T, Ivy DD, Curfs LM, Mattson SN, Riley EP, Treier M, Grossfeld PD.
Chromosomal microarray mapping suggests a role for BSX and
Neurogranin in neurocognitive and behavioral defects in the 11q terminal
deletion disorder (Jacobsen syndrome). Neurogenetics. 2009
Apr;10(2):89-95. PubMed PMID: 18855024; PubMed Central PMCID:
PMC3050515.
Mourani PM, Sontag MK, Ivy DD, Abman SH. Effects of long-term
sildenafil treatment for pulmonary hypertension in infants with chronic lung
disease. J Pediatr. 2009 Mar;154(3):379-84. PubMed PMID: 18950791;
PubMed Central PMCID: PMC2783835.
Bernus A, Wagner BD, Accurso F, Doran A, Kaess H, Ivy DD. Brain
natriuretic peptide levels in managing pediatric patients with pulmonary
arterial hypertension. Chest. 2009 Mar;135(3):745-51. PubMed PMID:
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Phelps CM, Mengshol S, Ivy DD. A curious isolated cystic lesion of the
membranous atrioventricular septum. Cardiol Young. 2008 Dec;18(6):6314. PubMed PMID: 18950547; PubMed Central PMCID: PMC3118089.
Malhotra SP, Lacour-Gayet F, Campbell DN, Miyamoto S, Clarke DR,
Dines ML, Ivy DD, Mitchell MB. Outcomes of reparative and
transplantation strategies for multilevel left heart obstructions with mitral
stenosis. Ann Thorac Surg. 2008 Oct;86(4):1305-9. PubMed PMID:
18805182; PubMed Central PMCID: PMC3128450.
Malhotra SP, Ivy DD, Mitchell MB, Campbell DN, Dines ML, Miyamoto S,
Kay J, Clarke DR, Lacour-Gayet F. Performance of cavopulmonary
palliation at elevated altitude: midterm outcomes and risk factors for
failure. Circulation. 2008 Sep 30;118(14 Suppl):S177-81. PubMed PMID:
18824752; PubMed Central PMCID: PMC3129266.
Doran AK, Ivy DD, Barst RJ, Hill N, Murali S, Benza RL; Scientific
Leadership Council of the Pulmonary Hypertension Association.
Guidelines for the prevention of central venous catheter-related blood
stream infections with prostanoid therapy for pulmonary arterial
hypertension. Int J Clin Pract Suppl. 2008 Jul;(160):5-9. PubMed PMID:
18638170; PubMed Central PMCID: PMC3129264.
Villavicencio K, Ivy D, Cole L, Nuss R. Symptomatic pulmonary
hypertension in a child with sickle cell disease. J Pediatr. 2008
Jun;152(6):879-81. doi: 10.1016/j.jpeds.2008.01.042. PubMed PMID:
18492535; PubMed Central PMCID: PMC3128440.
Hunter KS, Gross JK, Lanning CJ, Kirby KS, Dyer KL, Ivy DD, Shandas R.
Noninvasive methods for determining pulmonary vascular function in
children with pulmonary arterial hypertension: application of a mechanical
oscillator model. Congenit Heart Dis. 2008 Mar-Apr;3(2):106-16. PubMed
PMID: 18380759; PubMed Central PMCID: PMC3116924.
Mourani PM, Sontag MK, Younoszai A, Ivy DD, Abman SH. Clinical utility
of echocardiography for the diagnosis and management of pulmonary
vascular disease in young children with chronic lung disease. Pediatrics.
2008 Feb;121(2):317-25. PubMed PMID: 18245423; PubMed Central
PMCID: PMC3121163.
Mourani PM, Ivy DD, Rosenberg AA, Fagan TE, Abman SH. Left
ventricular diastolic dysfunction in bronchopulmonary dysplasia. J Pediatr.
2008 Feb;152(2):291-3. PubMed PMID: 18206706; PubMed Central
PMCID: PMC2259289.
Ivy DD, Doran AK, Smith KJ, Mallory GB Jr, Beghetti M, Barst RJ, Brady
D, Law Y, Parker D, Claussen L, Abman SH. Short- and long-term effects
of inhaled iloprost therapy in children with pulmonary arterial hypertension.
J Am Coll Cardiol. 2008 Jan 15;51(2):161-9. PubMed PMID: 18191742;
PubMed Central PMCID: PMC3125969.
Hunter KS, Lee PF, Lanning CJ, Ivy DD, Kirby KS, Claussen LR, Chan
KC, Shandas R. Pulmonary vascular input impedance is a combined
measure of pulmonary vascular resistance and stiffness and predicts
clinical outcomes better than pulmonary vascular resistance alone in
pediatric patients with pulmonary hypertension. Am Heart J. 2008
Jan;155(1):166-74. PubMed PMID: 18082509; PubMed Central PMCID:
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Yetman AT, Beroukhim RS, Ivy DD, Manchester D. Importance of the
clinical recognition of Loeys-Dietz syndrome in the neonatal period.
Pediatrics. 2007 May;119(5):e1199-202. PubMed PMID: 17470566;
PubMed Central PMCID: PMC3131201.
Zhang Y, Dunn ML, Hunter KS, Lanning C, Ivy DD, Claussen L, Chen SJ,
Shandas R. Application of a microstructural constitutive model of the
pulmonary artery to patient-specific studies: validation and effect of
orthotropy. J Biomech Eng. 2007 Apr;129(2):193-201. PubMed PMID:
17408324; PubMed Central PMCID: PMC3114451.
Ivy DD, Claussen L, Doran A. Transition of stable pediatric patients with
pulmonary arterial hypertension from intravenous epoprostenol to
intravenous treprostinil. Am J Cardiol. 2007 Mar 1;99(5):696-8. PubMed
PMID: 17317374; PubMed Central PMCID: PMC1974790.
Carmosino MJ, Friesen RH, Doran A, Ivy DD. Perioperative complications
in children with pulmonary hypertension undergoing noncardiac surgery or
cardiac catheterization. Anesth Analg. 2007 Mar;104(3):521-7. PubMed
PMID: 17312201; PubMed Central PMCID: PMC1934984.
Drexler ES, Quinn TP, Slifka AJ, McCowan CN, Bischoff JE, Wright JE,
Ivy DD, Shandas R. Comparison of mechanical behavior among the
extrapulmonary arteries from rats. J Biomech. 2007;40(4):812-9. PubMed
PMID: 16682044.
Artrip JH, Campbell DN, Ivy DD, Almodovar MC, Chan KC, Mitchell MB,
Clarke DR, Lacour-Gayet F. Birth weight and complexity are significant
factors for the management of hypoplastic left heart syndrome. Ann
Thorac Surg. 2006 Oct;82(4):1252-7. PubMed PMID: 16996917.
Hunter KS, Lanning CJ, Chen SY, Zhang Y, Garg R, Ivy DD, Shandas R.
Simulations of congenital septal defect closure and reactivity testing in
patient-specific models of the pediatric pulmonary vasculature: A 3D
numerical study with fluid-structure interaction. J Biomech Eng. 2006
Aug;128(4):564-72. PubMed PMID: 16813447.
Dyer K, Lanning C, Das B, Lee PF, Ivy DD, Valdes-Cruz L, Shandas R.
Noninvasive Doppler tissue measurement of pulmonary artery compliance
in children with pulmonary hypertension. J Am Soc Echocardiogr. 2006
Apr;19(4):403-12. PubMed PMID: 16581479; PubMed Central PMCID:
PMC2003158.
Resnik E, Herron J, Fu R, Ivy DD, Cornfield DN. Oxygen tension
modulates the expression of pulmonary vascular BKCa channel alphaand beta-subunits. Am J Physiol Lung Cell Mol Physiol. 2006
Apr;290(4):L761-L768. PubMed PMID: 16284215.
Dyer KL, Pauliks LB, Das B, Shandas R, Ivy D, Shaffer EM, Valdes-Cruz
LM. Use of myocardial performance index in pediatric patients with
idiopathic pulmonary arterial hypertension. J Am Soc Echocardiogr. 2006
Jan;19(1):21-7. PubMed PMID: 16423665; PubMed Central PMCID:
PMC1934985.
Ihida-Stansbury K, McKean DM, Gebb SA, Martin JF, Stevens T,
Nemenoff R, Vaughn J, Lane K, Loyd J, Wheeler L, Morrell NW, Ivy D,
Jones PL. Regulation and functions of the paired-related homeobox gene
PRX1 in pulmonary vascular development and disease. Chest. 2005
16
Dec;128(6 Suppl):591S. PubMed PMID: 16373852.
98. Imamura M, Vitello AM, Limbird JN, Ivy DD, Fallon MB, Carter EP.
Endothelin-B receptor overexpression prevents hypoxic pulmonary
hypertension in cirrhotic rats. Chest. 2005 Dec;128(6 Suppl):580S-581S.
PubMed PMID: 16373843.
99. Rosenzweig EB, Ivy DD, Widlitz A, Doran A, Claussen LR, Yung D,
Abman SH, Morganti A, Nguyen N, Barst RJ. Effects of long-term
bosentan in children with pulmonary arterial hypertension. J Am Coll
Cardiol. 2005 Aug 16;46(4):697-704. PubMed PMID: 16098438.
100. Zhang Y, Dunn ML, Drexler ES, McCowan CN, Slifka AJ, Ivy DD,
Shandas R. A microstructural hyperelastic model of pulmonary arteries
under normo- and hypertensive conditions. Ann Biomed Eng. 2005
Aug;33(8):1042-52. PubMed PMID: 16133913.
101. Condino AA, Ivy DD, O'Connor JA, Narkewicz MR, Mengshol S,
Whitworth JR, Claussen L, Doran A, Sokol RJ. Portopulmonary
hypertension in pediatric patients. J Pediatr. 2005 Jul;147(1):20-6.
PubMed PMID: 16027687; PubMed Central PMCID: PMC3326402.
102. Ivy DD, McMurtry IF, Colvin K, Imamura M, Oka M, Lee DS, Gebb S,
Jones PL. Development of occlusive neointimal lesions in distal
pulmonary arteries of endothelin B receptor-deficient rats: a new model of
severe pulmonary arterial hypertension. Circulation. 2005 Jun
7;111(22):2988-96. PubMed PMID: 15927975; PubMed Central PMCID:
PMC1934986.
103. Das BB, Narkewicz MR, Sokol RJ, Chen YT, Bali D, Li SC, Matthews MR,
Mierau GW, Ivy DD. Amylopectinosis disease isolated to the heart with
normal glycogen branching enzyme activity and gene sequence. Pediatr
Transplant. 2005 Apr;9(2):261-5. PubMed PMID: 15787805.
104. Kinsella JP, Ivy DD, Abman SH. Pulmonary vasodilator therapy in
congenital diaphragmatic hernia: acute, late, and chronic pulmonary
hypertension. Semin Perinatol. 2005 Apr;29(2):123-8. PubMed PMID:
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105. Yetman AT, Taylor AL, Doran A, Ivy DD. Utility of cardiopulmonary stress
testing in assessing disease severity in children with pulmonary arterial
hypertension. Am J Cardiol. 2005 Mar 1;95(5):697-9. PubMed PMID:
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106. Imamura M, Luo B, Limbird J, Vitello A, Oka M, Ivy DD, McMurtry IF,
Garat CV, Fallon MB, Carter EP. Hypoxic pulmonary hypertension is
prevented in rats with common bile duct ligation. J Appl Physiol (1985).
2005 Feb;98(2):739-47. PubMed PMID: 15516365.
107. Rashid A, Ivy D. Severe paediatric pulmonary hypertension: new
management strategies. Arch Dis Child. 2005 Jan;90(1):92-8. PubMed
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108. Das BB, Wolfe RR, Chan KC, Larsen GL, Reeves JT, Ivy D. High-altitude
pulmonary edema in children with underlying cardiopulmonary disorders
and pulmonary hypertension living at altitude. Arch Pediatr Adolesc Med.
2004 Dec;158(12):1170-6. PubMed PMID: 15583103.
109. Mitchell MB, Campbell DN, Ivy D, Boucek MM, Sondheimer HM, Pietra B,
Das BB, Coll JR. Evidence of pulmonary vascular disease after heart
transplantation for Fontan circulation failure. J Thorac Cardiovasc Surg.
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2004 Nov;128(5):693-702. PubMed PMID: 15514596.
110. Hartsfield CL, McMurtry IF, Ivy DD, Morris KG, Vidmar S, Rodman DM,
Fagan KA. Cardioprotective and vasomotor effects of HO activity during
acute and chronic hypoxia. Am J Physiol Heart Circ Physiol. 2004
Nov;287(5):H2009-15. PubMed PMID: 15217799.
111. Mourani PM, Ivy DD, Gao D, Abman SH. Pulmonary vascular effects of
inhaled nitric oxide and oxygen tension in bronchopulmonary dysplasia.
Am J Respir Crit Care Med. 2004 Nov 1;170(9):1006-13. PubMed PMID:
15184202.
112. Weinberg CE, Hertzberg JR, Ivy DD, Kirby KS, Chan KC, Valdes-Cruz L,
Shandas R. Extraction of pulmonary vascular compliance, pulmonary
vascular resistance, and right ventricular work from single-pressure and
Doppler flow measurements in children with pulmonary hypertension: a
new method for evaluating reactivity: in vitro and clinical studies.
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113. Fagan KA, Oka M, Bauer NR, Gebb SA, Ivy DD, Morris KG, McMurtry IF.
Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic
pulmonary hypertension in mice by inhibition of Rho-kinase. Am J Physiol
Lung Cell Mol Physiol. 2004 Oct;287(4):L656-64. PubMed PMID:
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114. Ivy DD, Doran A, Claussen L, Bingaman D, Yetman A. Weaning and
discontinuation of epoprostenol in children with idiopathic pulmonary
arterial hypertension receiving concomitant bosentan. Am J Cardiol. 2004
Apr 1;93(7):943-6. PubMed PMID: 15050507; PubMed Central PMCID:
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115. Ivy DD, Lee DS, Rairigh RL, Parker TA, Abman SH. Endothelin B receptor
blockade attenuates pulmonary vasodilation in oxygen-ventilated fetal
lambs. Biol Neonate. 2004;86(3):155-9. PubMed PMID: 15205573.
116. Wright JE, Drexler ES, Slifka AJ, McCowan CN, Ivy DD, Shandas R.
Stress and strain in rat pulmonary artery material during a biaxial bubble
test. Biomed Sci Instrum. 2004;40:303-8. PubMed PMID: 15133975.
106. Drexler ES, McCowan CN, Wright JE, Slifka AJ, Ivy DD, Shandas R.
Comparison of strength properties of normotensive and hypertensive rat
pulmonary arteries. Biomed Sci Instrum. 2004;40:297-302. PubMed PMID:
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107. Das BB, Sahoo S, Ivy DD. Neonatal aortic arch thrombosis masquerading
as coarctation of the aorta. Pediatr Cardiol. 2004 Jan-Feb;25(1):80-3.
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108. Bourke KD, Sondheimer HM, Ivy DD, Pietra B, Gleason BK, Mashburn C,
Boucek MM. Improved pretransplant management of infants with
hypoplastic left heart syndrome enables discharge to home while waiting
for transplantation. Pediatr Cardiol. 2003 Nov-Dec;24(6):538-43. PMID:
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109. Ivy DD, Parker D, Doran A, Parker D, Kinsella JP, Abman SH. Acute
hemodynamic effects and home therapy using a novel pulsed nasal nitric
oxide delivery system in children and young adults with pulmonary
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110. Carpenter T, Schomberg S, Steudel W, Ozimek J, Colvin K, Stenmark K,
Ivy DD. Endothelin B receptor deficiency predisposes to pulmonary edema
formation via increased lung vascular endothelial cell growth factor
expression. Circ Res. 2003 Sep 5;93(5):456-63. PubMed PMID:
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111. Mitchell MB, Campbell DN, Boucek MM, Sondheimer HM, Chan KC, Ivy
DD, Pietra B, Mackenzie T. Mechanical limitation of pulmonary blood flow
facilitates heart transplantation in older infants with hypoplastic left heart
syndrome. Eur J Cardiothorac Surg. 2003 May;23(5):735-42. PubMed
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112. Balasubramaniam V, Le Cras TD, Ivy DD, Grover TR, Kinsella JP, Abman
SH. Role of platelet-derived growth factor in vascular remodeling during
pulmonary hypertension in the ovine fetus. Am J Physiol Lung Cell Mol
Physiol. 2003 May;284(5):L826-33. PubMed PMID: 12533438.
113. Kinsella JP, Parker TA, Ivy DD, Abman SH. Noninvasive delivery of
inhaled nitric oxide therapy for late pulmonary hypertension in newborn
infants with congenital diaphragmatic hernia. J Pediatr. 2003
Apr;142(4):397-401. PubMed PMID: 12712057.
114. Barst RJ, Ivy D, Dingemanse J, Widlitz A, Schmitt K, Doran A, Bingaman
D, Nguyen N, Gaitonde M, van Giersbergen PL. Pharmacokinetics, safety,
and efficacy of bosentan in pediatric patients with pulmonary arterial
hypertension. Clin Pharmacol Ther. 2003 Apr;73(4):372-82. PubMed
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115. Balzer DT, Kort HW, Day RW, Corneli HM, Kovalchin JP, Cannon BC,
Kaine SF, Ivy DD, Webber SA, Rothman A, Ross RD, Aggarwal S,
Takahashi M, Waldman JD. Inhaled Nitric Oxide as a Preoperative Test
(INOP Test I): the INOP Test Study Group. Circulation. 2002 Sep
24;106(12 Suppl 1):I76-81. PubMed PMID: 12354713.
116. Arce OX, Knudson OA, Ellison MC, Baselga P, Ivy DD, Degroff C, ValdesCruz L. Longitudinal motion of the atrioventricular annuli in children:
reference values, growth related changes, and effects of right ventricular
volume and pressure overload. J Am Soc Echocardiogr. 2002
Sep;15(9):906-16. PubMed PMID: 12221407.
117. Ivy DD, Yanagisawa M, Gariepy CE, Gebb SA, Colvin KL, McMurtry IF.
Exaggerated hypoxic pulmonary hypertension in endothelin B receptordeficient rats. Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L70312. PubMed PMID: 11880295.
118. Epting CL, Wolfe RR, Abman SH, Deutsch GH, Ivy D. Reversal of
pulmonary hypertension associated with plexiform lesions in congenital
heart disease: a case report. Pediatr Cardiol. 2002 Mar-Apr;23(2):182-5.
Epub 2002 Feb 19. PubMed PMID: 11889532.
119. Ivy D, Tanzawa K, Abman SH. Ontogeny of endothelin-converting enzyme
gene expression and protein content in the ovine fetal lung. Biol Neonate.
2002;81(2):139-44. PubMed PMID: 11844885.
120. Shandas R, Weinberg C, Ivy DD, Nicol E, DeGroff CG, Hertzberg J,
Valdes-Cruz L. Development of a noninvasive ultrasound color M-mode
means of estimating pulmonary vascular resistance in pediatric pulmonary
hypertension: mathematical analysis, in vitro validation, and preliminary
clinical studies. Circulation. 2001 Aug 21;104(8):908-13. PubMed PMID:
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121. Ivy D. Diagnosis and treatment of severe pediatric pulmonary
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122. Ivy D, McMurtry IF, Yanagisawa M, Gariepy CE, Le Cras TD, Gebb SA,
Morris KG, Wiseman RC, Abman SH. Endothelin B receptor deficiency
potentiates ET-1 and hypoxic pulmonary vasoconstriction. Am J Physiol
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123. Rairigh RL, Parker TA, Ivy DD, Kinsella JP, Fan ID, Abman SH. Role of
inducible nitric oxide synthase in the pulmonary vascular response to birthrelated stimuli in the ovine fetus. Circ Res. 2001 Apr 13;88(7):721-6.
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124. Torielli F, Fashaw LM, Knudson O, Kinsella J, Ivy D, Valdes-Cruz L,
Rosenberg A. Echocardiographic outcome of infants treated as newborns
with inhaled nitric oxide for severe hypoxemic respiratory failure. J Pediatr.
2001 Mar;138(3):349-54. PubMed PMID: 11241041.
125. Ivy D, Eells P. Diagnosis and treatment of pulmonary hypertension in the
adolescent. Adolesc Med. 2001 Feb;12(1):79-93. Review. PubMed PMID:
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126. Ivy DD, Parker TA, Abman SH. Prolonged endothelin B receptor blockade
causes pulmonary hypertension in the ovine fetus. Am J Physiol Lung Cell
Mol Physiol. 2000 Oct;279(4):L758-65. PubMed PMID: 11000137.
127. Ivy DD, le Cras TD, Parker TA, Zenge JP, Jakkula M, Markham NE,
Kinsella JP, Abman SH. Developmental changes in endothelin expression
and activity in the ovine fetal lung. Am J Physiol Lung Cell Mol Physiol.
2000 Apr;278(4):L785-93. PubMed PMID: 10749756.
128. Parker TA, Ivy DD, Galan HL, Grover TR, Kinsella JP, Abman SH.
Estradiol improves pulmonary hemodynamics and vascular remodeling in
perinatal pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol.
2000 Feb;278(2):L374-81. PubMed PMID: 10666122.
129. Holcomb RG, Tyson RW, Ivy DD, Abman SH, Kinsella JP. Congenital
pulmonary venous stenosis presenting as persistent pulmonary
hypertension of the newborn. Pediatr Pulmonol. 1999 Oct;28(4):301-6.
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130. Ziegler JW, Ivy DD, Wiggins JW, Kinsella JP, Clarke WR, Abman SH.
Effects of dipyridamole and inhaled nitric oxide in pediatric patients with
pulmonary hypertension. Am J Respir Crit Care Med. 1998 Nov;158(5 Pt
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131. Ivy DD, Griebel JL, Kinsella JP, Abman SH. Acute hemodynamic effects
of pulsed delivery of low flow nasal nitric oxide in children with pulmonary
hypertension. J Pediatr. 1998 Sep;133(3):453-6. PubMed PMID: 9738734.
132. Ivy DD, Parker TA, Kinsella JP, Abman SH. Endothelin A receptor
blockade decreases pulmonary vascular resistance in premature lambs
with hyaline membrane disease. Pediatr Res. 1998 Aug;44(2):175-80.
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133. Ivy DD, Le Cras TD, Horan MP, Abman SH. Chronic intrauterine
pulmonary hypertension increases preproendothelin-1 and decreases
endothelin B receptor mRNA expression in the ovine fetal lung. Chest.
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1998 Jul;114(1 Suppl):65S. PubMed PMID: 9676634.
134. Ivy DD, Ziegler JW, Kinsella JP, Wiggins JW, Abman SH. Hemodynamic
effects of dipyridamole and inhaled nitric oxide in pediatric patients with
pulmonary hypertension. Chest. 1998 Jul;114(1 Suppl):17S. PubMed
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135. Ivy DD, Kinsella JP, Ziegler JW, Abman SH. Dipyridamole attenuates
rebound pulmonary hypertension after inhaled nitric oxide withdrawal in
postoperative congenital heart disease. J Thorac Cardiovasc Surg. 1998
Apr;115(4):875-82. PubMed PMID: 9576224.
136. Ivy DD, Le Cras TD, Horan MP, Abman SH. Increased lung preproET-1
and decreased ETB-receptor gene expression in fetal pulmonary
hypertension. Am J Physiol. 1998 Apr;274(4 Pt 1):L535-41. PubMed
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137. Ziegler JW, Ivy DD, Fox JJ, Kinsella JP, Clarke WR, Abman SH.
Dipyridamole potentiates pulmonary vasodilation induced by acetylcholine
and nitric oxide in the ovine fetus. Am J Respir Crit Care Med. 1998
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138. Ivy DD, Neish SR, Knudson OA, Nihill MR, Schaffer MS, Tyson RW,
Abman SH, Shaffer EM, Valdes-Cruz L. Intravascular ultrasonic
characteristics and vasoreactivity of the pulmonary vasculature in children
with pulmonary hypertension. Am J Cardiol. 1998 Mar 15;81(6):740-8.
PubMed PMID: 9527085.
139. Rairigh RL, Le Cras TD, Ivy DD, Kinsella JP, Richter G, Horan MP, Fan
ID, Abman SH. Role of inducible nitric oxide synthase in regulation of
pulmonary vascular tone in the late gestation ovine fetus. J Clin Invest.
1998 Jan 1;101(1):15-21. PubMed PMID: 9421461; PubMed Central
PMCID: PMC508535.
140. Ivy DD, Parker TA, Ziegler JW, Galan HL, Kinsella JP, Tuder RM, Abman
SH. Prolonged endothelin A receptor blockade attenuates chronic
pulmonary hypertension in the ovine fetus. J Clin Invest. 1997 Mar
15;99(6):1179-86. PubMed PMID: 9077525; PubMed Central PMCID:
PMC507931.
141. Parker TA, Ivy DD, Kinsella JP, Torielli F, Ruyle SZ, Thilo EH, Abman SH.
Combined therapy with inhaled nitric oxide and intravenous prostacyclin in
an infant with alveolar-capillary dysplasia. Am J Respir Crit Care Med.
1997 Feb;155(2):743-6. PubMed PMID: 9032222.
142. Ivy DD, Kinsella JP, Abman SH. Endothelin blockade augments
pulmonary vasodilation in the ovine fetus. J Appl Physiol (1985). 1996
Dec;81(6):2481-7. PubMed PMID: 9018495.
143. Fox JJ, Ziegler JW, Ivy DD, Halbower AC, Kinsella JP, Abman SH. Role of
nitric oxide and cGMP system in regulation of ductus arteriosus tone in
ovine fetus. Am J Physiol. 1996 Dec;271(6 Pt 2):H2638-45. PubMed
PMID: 8997326.
144. Ivy DD, Ziegler JW, Dubus MF, Fox JJ, Kinsella JP, Abman SH. Chronic
intrauterine pulmonary hypertension alters endothelin receptor activity in
the ovine fetal lung. Pediatr Res. 1996 Mar;39(3):435-42. PubMed PMID:
8929863.
145. Abman SH, Ivy DD, Ziegler JW, Kinsella JP. Mechanisms of abnormal
vasoreactivity in persistent pulmonary hypertension of the newborn infant.
21
J Perinatol. 1996 Mar-Apr;16(2 Pt 2 Su):S18-23. PubMed PMID: 8732544.
146. Ivy DD, Kinsella JP, Wolfe RR, Abman SH. Atrial natriuretic peptide and
nitric oxide in children with pulmonary hypertension after surgical repair of
congenital heart disease. Am J Cardiol. 1996 Jan 1;77(1):102-5. PubMed
PMID: 8540445.
147. Kinsella JP, Torielli F, Ziegler JW, Ivy DD, Abman SH. Dipyridamole
augmentation of response to nitric oxide. Lancet. 1995 Sep
2;346(8975):647-8. PubMed PMID: 7651043.
148. Ziegler JW, Ivy DD, Fox JJ, Kinsella JP, Clarke WR, Abman SH.
Dipyridamole, a cGMP phosphodiesterase inhibitor, causes pulmonary
vasodilation in the ovine fetus. Am J Physiol. 1995 Aug;269(2 Pt 2):H4739. PubMed PMID: 7653611.
149. Ziegler JW, Ivy DD, Kinsella JP, Abman SH. The role of nitric oxide,
endothelin, and prostaglandins in the transition of the pulmonary
circulation. Clin Perinatol. 1995 Jun;22(2):387-403. PubMed PMID:
7671544.
150. Ivy DD, Shaffer EM, Johnson AM, Kimberling WJ, Dobin A, Gabow PA.
Cardiovascular abnormalities in children with autosomal dominant
polycystic kidney disease. J Am Soc Nephrol. 1995 Jun;5(12):2032-6.
PubMed PMID: 7579051.
151. McQueston JA, Kinsella JP, Ivy DD, McMurtry IF, Abman SH. Chronic
pulmonary hypertension in utero impairs endothelium-dependent
vasodilation. Am J Physiol. 1995 Jan;268(1 Pt 2):H288-94. PubMed PMID:
7840274.
152. Kinsella JP, Ivy DD, Abman SH. Ontogeny of NO activity and response to
inhaled NO in the developing ovine pulmonary circulation. Am J Physiol.
1994 Nov;267(5 Pt 2):H1955-61. PubMed PMID: 7977827.
153. Kinsella JP, Ivy DD, Abman SH. Inhaled nitric oxide improves gas
exchange and lowers pulmonary vascular resistance in severe
experimental hyaline membrane disease. Pediatr Res. 1994
Sep;36(3):402-8. PubMed PMID: 7808839.
154. Ivy DD, Wiggins JW, Badesch DB, Kinsella JP, Kelminson LL, Abman SH.
Nitric oxide and prostacyclin treatment of an infant with primary pulmonary
hypertension. Am J Cardiol. 1994 Aug 15;74(4):414-6. PubMed PMID:
8059714.
155. Ivy DD, Kinsella JP, Abman SH. Physiologic characterization of endothelin
A and B receptor activity in the ovine fetal pulmonary circulation. J Clin
Invest. 1994 May;93(5):2141-8. PubMed PMID: 8182146; PubMed Central
PMCID: PMC294348.
156. Ivy D, Kaye J, Flitter D, Wiggins J. Variant angina in an adolescent.
Pediatr Cardiol. 1994 Jan-Feb;15(1):45-7. PubMed PMID: 8115273.
157. Ivy D, Loehr J, Schaffer M. Usefulness of prolonged prostaglandin
infusion in neonates with Ebstein's anomaly. Am J Cardiol. 1993 Dec
1;72(17):1327-9. PubMed PMID: 8256717.
158. Kinsella JP, Neish SR, Ivy DD, Shaffer E, Abman SH. Clinical responses
to prolonged treatment of persistent pulmonary hypertension of the
newborn with low doses of inhaled nitric oxide. J Pediatr. 1993
Jul;123(1):103-8. PubMed PMID: 8320602.
22
Book Editor
Beghetti M, Barst RJ, Berger RM, Humpl T, Ivy DD, Schulze-Neick I (editors):
Pediatric Pulmonary Hypertension. Munich: Elsevier Urban & Fischer, 2011
Da Cruz E, Ivy DD, Jaggers JJ. Pediatric Cardiology, Cardiac Surgery, and
Cardiac Intensive Care. London: Springer, 2013
Book Chapters and Scholarly Reviews
1. Ziegler JZ, Ivy DD, Kinsella JP, and Abman SH. The role of nitric oxide,
endothelin and prostagaldins in the transition of the pulmonary circulation.
Clinics in Perinatology 22 (2): 387-403, 1995
2. Ivy DD, Abman SH, Wolfe RR. Congenital Heart Disease. In: Peacock AJ, Ed.
The Pulmonary Circulation: A Handbook For Clinicians. London, UK:
Chapman and Hall, 1996:449-466
3. Abman SH, Ivy DD, Ziegler JW, and Kinsella JP. Mechanisms of abnormal
vasoreactivity in persistent pulmonary hypertension of the newborn infant.
J Perinatology 16(2 Pt 2 Su): S18-23, 1996
4. Ivy DD, Shaffer EM, Schaffer MS. Heart. In: Merenstein GB, Kaplan DW,
Rosenberg AA, Eds. Handbook of Pediatrics. Stamford, Connecticut: Appleton
& Lange, 1997:511-547
5. Ivy DD, Neish SH, Abman SH. Control of the Pulmonary Circulation. In:
MacNamara D, Bricker T, Neish SR, Eds. The Science and Practice of
Pediatric Cardiology. Malvern, PA: Lea and Febiger, 1998:329-347
6. Ivy DD. Echocardiographic Evaluation of Pulmonary Hypertension. In: ValdesCruz L, Cayre R, Eds. Echocardiographic Anatomy of Congenital Heart Disease,
1999:537-547
7. Ivy DD, Abman SH. The Role of Endothelin in Perinatal Pulmonary Vasoregulation. In:
Weir EK, Archer SL, Reeves JT (Eds.). The Fetal and Neonatal Pulmonary Circulations,
1999: 279-302
8. Sondheimer HM, Boucek MM, Ivy DD, Lorts A, Schaffer MS, and Wolfe RR.
Cardiovascular Diseases. In: Hay WW, Hayward AR, Levin MJ, and Sondheimer JM,
Eds. Current Pediatric Diagnosis and Treatment, 2000
9. Ivy DD. Diagnosis and management of severe pediatric pulmonary hypertension.
Cardiology in Review 9(4): 227-237, 2001
10. Ivy DD and Eells P. Diagnosis and treatment of pulmonary hypertension in the
adolescent. Adolescent Medicine: State of the Art Reviews 12(1): 79-93, 2001
11. Rashid A and Ivy DD. Diagnosis and Management of Severe Pediatric Pulmonary
Hypertension. Current Concepts in Pediatric Critical Care 43-58, 2004
12. Rashid A and Ivy DD. Severe Paediatric Pulmonary Hypertension: New Management
Strategies. Archives of Disease in Childhood (90): 92-98, 2005
13. Rashid A and Ivy DD. New management strategies in severe paediatric pulmonary
hypertension. Cardiology Today 9(2): 100-108, 2005
23
14. Kinsella JP, Ivy DD and Abman SH. Pulmonary vasodilator therapy in congenital
diaphragmatic hernia: acute, late, and chronic pulmonary hypertension.
Seminars in Perinatology 29: 123-128, 2005
15. Rashid A and Ivy DD. Pulmonary hypertension. In: Slonim AD and Pollack MM, Eds.
Pediatric Critical Care Medicine, 2006:694-704
16. Rashid A and Ivy DD. Pulmonary hypertension in children. Current Paediatrics 16:
237-247, 2006
17. Ivy DD. Pulmonary arterial hypertension assessment in pediatric cardiology. In:
Beghetti, Barst, Naeije, Rubin Eds. Pulmonary Arterial Hypertension Related to
Congenital Heart Disease. Munich: Elsevier, 2006:93-111
18. Rashid A and Ivy DD. Pulmonary hypertension in children. In: Mandel and Taichman
Eds. Pulmonary Vascular Disease. Philadelphia, PA: Saunders and Elsevier, 2006:274287
19. Ivy DD, Feinstein JA, Humpl T, Rosenzweig E. Non congenital heart disease
associated pediatric pulmonary arterial hypertension. Progress in Pediatric
Cardiology 9(4): 227-237, 2009
20. Rosenzweig EB, Feinstein J, Humpl T, and Ivy DD. Pulmonary Arterial Hypertension
in Children: Diagnostic work-up and challenges. Progress in Pediatric Cardiology
9(4): 227-237, 2009
21. Mallory G, Ivy DD, Shardonovsky F, and Hanna B. Management and Controversies
in Pediatric Pulmonary Hypertension. Pediatric Asthma, Allergy & Immunology
22(4): 139-150, 2009
22. Tissot C, Ivy DD, and Beghetti M. Update on pulmonary arterial hypertension
focusing on new therapies. Journal of Pediatrics 157(4): 528-532, 2010
23. Ivy DD. Prostanoids in pediatric pulmonary hypertension. Pediatric Critical Care
Medicine 9(4): 227-237, 2010
24. Kozik D, Ivy DD , Ibrahim J, Wise-Faberowski L, Goldberg S, Darst J, Kaufman J,
Morell V, and da Cruz E. Patent Ductus Arteriosus. In: Ricardo Munoz, Victor Morell,
Eduardo da Cruz, and Carol Vetterly Eds. Critical Care of Children with Heart Disease:
Basic Medical and Surgical Concepts. London: Springer-Verlag, 2010:145-157
25. Kaufman J, Goldberg S, Ibrahim J, Ivy DD, Wise-Faberowski L, Buckvold S, Tissot C,
Phelps C, Morell V, and da Cruz E. Complete Atrioventricular Septal Defect. In: Ricardo
Munoz, Victor Morell, Eduardo da Cruz, and Carol Vetterly Eds. Critical Care of Children
with Heart Disease: Basic Medical and Surgical Concepts. London: Springer-Verlag,
2010:177-189
26. da Cruz E, Goldberg S, Kaufman J, Artico A, Mackie S, Church J, Stimmler A, Rutz J,
Kozik D, Ivy DD, Lacour-Gayet F, and Vouhe P. Single Ventricle, Basic Concepts. In:
Ricardo Munoz, Victor Morell, Eduardo da Cruz, and Carol Vetterly Eds. Critical Care of
Children with Heart Disease: Basic Medical and Surgical Concepts. London: SpringerVerlag, 2010:331-348
27. da Cruz E, Kaufman J, Morell V, Tissot C, Buckvold S, Goldberg S, Ivy DD, Ibrahim
J, Wise-Faberowski L, and Kalangos A. Ebstein’s Anomaly. In: Ricardo Munoz, Victor
Morell, Eduardo da Cruz, andCarol Vetterly Eds. Critical Care of Children with Heart
Disease: Basic Medical and Surgical Concepts. London: Springer-Verlag, 2010:411-421
28. Ivy DD and Rashid A. Chronic Pulmonary Hypertension. In: Ricardo Munoz, Victor
Morell, Eduardo da Cruz, andCarol Vetterly Eds. Critical Care of Children with Heart
Disease: Basic Medical and Surgical Concepts. London: Springer-Verlag, 2010:483-505
29. Ivy DD, Saji B. A new era in medical management of severe pediatric pulmonary
arterial hypertension. Pediatric Cardiology and Cardiac Surgery. 26(3):206-218, 2010
24
30. Hunter KS, Feinstein JA, Ivy DD, and Shandas RS. Computational
simulation of the pulmonary arteries and its role in the study of pediatric
pulmonary hypertension. Progress in Pediatric Cardiology 30(1-2):63-69, 2010
31. Tissot C, Ivy DD. Echocardiographic evaluation of pulmonary arterial hypertension in
children. In: Beghetti M, Barst RJ, Berger RM, Humpl T, Ivy DD, Schulze-Neick I (editors):
Pediatric Pulmonary Hypertension. Munich: Elsevier Urban & Fischer, 2011:131-154
32. Ivy DD, Saji B. Treatment of pulmonary arterial hypertension in children. In: Beghetti
M, Barst RJ, Berger RM, Humpl T, Ivy DD, Schulze-Neick I (editors): Pediatric
Pulmonary Hypertension. Munich: Elsevier Urban & Fischer, 2011:315-328
33. Ivy DD. Idiopathic pulmonary arterial hypertension in children. In: Peacock AJ, Ed.
The Pulmonary Circulation: A Handbook For Clinicians. London, UK: Chapman and Hall,
2011:559-571
34. Ivy DD. Pulmonary Hypertension. In: McMillan, Barrett, Boney, and Jones
eds. Clinical Decision Support: Pediatrics, 2012
35. Ivy DD. Diagnosis and Treatment of Pediatric Pulmonary Hypertension. In:
Allen, Shaddy, Driscoll, Eds. Moss and Adams: Congenital Heart Disease.
Philadelphia, Wolters Kluwer Health Lippincott Williams & Wilkins. 1433-1462,
2012
36. Takatsuki S, Beghetti M, Ivy DD. Pulmonary hypertension in Children. In:
Hoeper, Humbert, Eds. European Respiratory Monograph. 57:94–107, 2012
37. Takatsuki S, Ivy DD. Current Challenges in Pediatric Pulmonary
Hypertension. Seminars in Respiratory and Critical Care Medicine 34:627–644,
2013
38. Vorhies EE, Ivy DD. Drug Treatment of Pulmonary Hypertension in Children.
Paediatr Drugs. 2014 Feb;16(1):43-65.
39. Takatsuki S, Eshelman J, Berg, A, Ivy DD. Pharmacological treatment of
Pulmonary Hypertension. RMunoz, et al. (eds.), Handbook of Pediatric
Cardiovascular Drugs, Springer-Verlag London 2014
40. Jone P, Ivy DD. Echocardiography in pediatric pulmonary hypertension. Front
Pediatr. 2014;2:124.
41. Ivy DD. Idiopathic pulmonary arterial hypertension in children. In: Peacock
AJ, Ed. The Pulmonary Circulation: A Handbook For Clinicians. London, UK:
Chapman and Hall, 2015
42. Ivy DD. Diagnosis and Treatment of Pediatric Pulmonary Hypertension. In:
Allen, Shaddy, Driscoll, Eds. Moss and Adams: Congenital Heart Disease.
Philadelphia, Wolters Kluwer Health Lippincott Williams & Wilkins, 2015
Abstracts Accepted for Presentation
1. Ivy DD, Kinsella JP and Abman SH. BQ 123, an endothelin A receptor
antagonist, causes ovine fetal pulmonary vasodilation. Children's National
Medical Center ECMO Symposium, 1993
2. Ivy DD, Kinsella JP and Abman SH. Physiologic characterization of endothelin
A and B receptor activity in the ovine fetal pulmonary circulation. Pediatr Res 33 (4):
247A, 1993
3. Kinsella JP, Ivy DD and Abman SH. Maturational changes in endotheliumderived nitric oxide activity in the developing pulmonary circulation. Pediatr Res 33 (4):
332A, 1993
4. McQueston JA, Kinsella JP, Ivy DD and Abman SH. Changes in endotheliumdependent and independent vasodilation during chronic intrauterine
25
pulmonary hypertension in fetal lambs. Pediatr Res 33 (4): 337A, 1993
5. Ivy DD, Schaffer MS and Loehr JP. Prolonged prostaglandin infusion in
neonates with severe Ebstein's Anomaly. World Congress of Pediatric
Cardiology. Paris, France, 1993
6. Ivy DD, Kinsella JP and Abman SH. Role of endothelin in autoregulation of
blood flow in the ovine fetal lung. Pediatr Res 35 (4): 338A, 1994
7. Ivy DD, Kinsella JP, Wolfe RR, and Abman SH. Hemodynamic responses to
atrial natriuretic peptide and inhaled nitric oxide in pediatric pulmonary
hypertension. Pediatr Res 35 (4): 36A, 1994
8. Kinsella JP, Ivy DD and Abman SH. Inhaled nitric oxide improves gas
exchange and lowers pulmonary vascular resistance in severe experimental
hyaline membrane disease. Pediatr Res 35 (4): 340A, 1994
9. Ziegler JW, Ivy DD, Kinsella JP, Clarke WR and Abman SH. Dipyridamole, a
cGMP phosphodiesterase inhibitor, augments inhaled nitric oxide -induced
pulmonary vasodilation in the ovine transitional circulation. Pediatr Res 35 (4):
90A, 1994
10. Ivy DD, Ziegler JW, Fox JJ, Kinsella JP and Abman SH. Chronic intrauterine
pulmonary hypertension alters endothelin receptor activity in the ovine fetus.
Pediatr Res 37 (4): 27A, 1995
11. Ziegler JW, Ivy DD, Fox JJ, Kinsella JP and Abman SH. Hemodynamic effects
of cGMP phosphodiesterase inhibitors during chronic pulmonary hypertension.
Pediatr Res 37 (4): 38A, 1995
12. Ziegler JW, Ivy DD, Fox JJ, Kinsella JP, WR Clarke and Abman SH.
Dipyridamole, a cGMP phosphodiesterase inhibitor, augments endotheliumindependent vasodilation in the ovine fetal lung. Pediatr Res 37 (4): 38A, 1995
13. Fox JJ, Ziegler JW, Kinsella JP, Ivy DD, Halbower AC and Abman SH. Role
of the nitric oxide-cGMP system in regulation of tone of the ovine ductus
arteriosus. Pediatr Res 37 (4): 76A, 1995
14. Ziegler JW, Fox JJ, Ivy DD, Kinsella JP and Abman SH. Potassium channel
blockade does not inhibit nitric-oxide-induced vasodilation in the ovine perinatal lung.
Pediatr Res 37 (4): 81A, 1995
15. Kennaugh JM, Moreland SM, Fashaw LM, Rosenberg AR, Kinsella JP, Abman
SH, Ivy DD and Torielli FM. Neurodevelpomental and medical follow-up of
infants with PPHN treated with inhaled nitric oxide. Pediatr Res 37 (4): 261A, 1995
16. Kinsella JP, Halbower AC, Ziegler JW, Fox JJ, Ivy DD, and Abman SH. Lowdose inhaled nitric oxide improves gas exchange without changing vascular
permeability in experimental hyaline membrane disease. Pediatr Res 37 (4): 337A, 1995
17. Torielli F, Ivy DD, Abman SH, Kinsella JP, Moreland S, Rosenberg A,
Knudson OA, Valdez-Cruz L. Long term echocardiographic outcome of infants
with severe persistent pulmonary hypertension of the newborn after treatment
with nitric oxide and/or high frequency oscillatory ventilation.
American Academy of Pediatrics, 1995
18. Ivy DD, Neish SR, Knudson OA, Schaffer MS, Wiggins JW, Shaffer EM,
Nihill MR, and Valdes-Cruz LM. Intravascular ultrasound of pulmonary arteries
in children with pulmonary hypertension. J Am Coll Cardiol 27 (2): 324A, 1996
19. Ivy DD, Kinsella JP, Ziegler JW, and Abman SH. Dipyridamole, a cGMP
phosphodiesterase inhibitor, attenuates rebound pulmonary hypertension after
withdrawal of inhaled nitric oxide in postoperative congenital heart disease.
Pediatr Res 39 (4): 30A, 1996
26
20. Ivy DD, Parker TA, Ziegler JW, Galan HL, Kinsella JP and Abman SH.
Prolonged endothelin A receptor blockade attenuates chronic intrauterine
pulmonary hypertension. Pediatr Res 39 (4): 335A, 1996
21. Ziegler JW, Ivy DD, Kinsella JP, Wiggins JW, and Abman SH. Hemodynamic
effects of dipyridamole and inhaled nitric oxide in patients with severe pulmonary
hypertension. Pediatr Res 39 (4): 40A, 1996
22. Torielli F, Moreland SG, Ivy DD, Abman SH, Kinsella JP, Rosenberg AA,
Knudson OA, and Valdez-Cruz L. Long term echocardiographic follow-up of
infants with severe persistent pulmonary hypertension of the newborn. Pediatr
Res 39 (4): 282A, 1996
23. Kinsella JP, Parker TA, Galan HL, Ivy DD, and Abman SH. High frequency
oscillatory ventilation augments the response to inhaled nitric oxide in severe
experimental hyaline membrane disease. Pediatr Res 39 (4): 336A, 1996
24. Parker TA, Ivy DD, Galan HL, Kinsella JP and Abman SH.
Effects of chronic estradiol administration in an experimental model of persistent
pulmonary hypertension of the newborn. 25th Aspen Conference on Perinatal Research,
Aspen, CO, 1996
25. Pietra BP, Ivy DD, Sondheimer HM, Luna M, Schneider K, Hall P, Campbell
DC, Fullerton D, Kinsella JP, Abman SH, and Boucek MM. Use of post-operative
pulmonary vasodilators for orthotopic heart transplantation in hypoplastic left heart
syndrome: inhaled nitric oxide and milrinone. Third Loma Linda International Conference
on Pediatric Heart and Lung Transplantation. January 1997
26. Sondheimer HM, Pietra BP, Luna M, Schneider K, Hall P, Ivy DD, Campbell
DC, and Boucek MM. Pre- and post-transplantation management of infants with
hypoplastic left heart syndrome. Third Loma Linda International
Conference on Pediatric Heart and Lung Transplantation. January 1997
27. Boucek MM, Pietra BP, Shaffer EM, Sondheimer HM, Ivy DD, Luna M,
Schneider K, Hall P, and Campbell DC. Improved overall (pre & post) cardiac
transplant survival in infancy: strategies to regulate pulmonary resistance. J Am Coll
Cardiol 29 (2): 105A, 1997
28. Ivy DD, Le Cras TD, Horan MP, and Abman SH. Increased lung preproendothelin-1 and decreased endothelin B receptor mRNA expression after chronic
intrauterine pulmonary hypertension in the ovine fetus. Pediatr Res 41(4): 21A, 1997
29. Ivy DD, Kinsella JP, Parker TA, and Abman SH. Endothelin A receptor blockade
decreases pulmonary vascular resistance in severe experimental hyaline membrane
disease. Pediatr Res 41(4): 21A, 1997
30. Parker TA, Ivy DD, Galan HL, Kinsella JP and Abman SH.
Intrauterine treatment with estradiol improves hemodynamics and vascular
remodeling in an ovine model of pulmonary hypertension. Pediatr Res 41(4): 264A, 1997
31. Rairigh RL, Ivy DD, Kinsella JP, and Abman SH. Inducible nitric oxide
synthase inhibitors increase pulmonary vascular resistance in the late-gestation
fetus. Pediatr Res 41(4): 58A, 1997
32. Best TH, Ivy DD, Kinsella JP, Fox JJ, and Abman SH. Pulmonary vascular
effects of selective cGMP-specific (type V) phosphodiesterase inhibitors in the
ovine fetus. Pediatr Res 41(4): 55A, 1997
33. Ivy DD, Le Cras TD, Horan MP, and Abman SH. Increased lung preproendothelin-1 and decreased endothelin B receptor mRNA expression after chronic
intrauterine pulmonary hypertension in the ovine fetus. Chest 114(1): 65S, 1998
34. Ivy DD, Ziegler JW, Kinsella JP, Wiggins JW, and Abman SH. Hemodynamic
27
effects of dipyridamole and inhaled nitric oxide in pediatric patients with pulmonary
hypertension. Chest 114(1): 17S, 1998
35. Ivy DD, Le Cras TD, Horan MP, and Abman SH. Developmental regulation of
endothelin gene expression in the ovine lung. Pediatr Res 43(4): 287A, 1998
36. Ivy DD, Griebel JL, Kinsella JP, and Abman SH. Acute hemodynamic effects of
pulsed delivery of low flow nasal nitric oxide in children with pulmonary
hypertension. Pediatr Res 43(4): 23A, 1998
37. Ivy DD, McMurtry IF, Yanagisawa M, Gariepy CE, Morris KG, Jakkula M, OliverPickett C, and Abman SH. Exaggerated hypoxic pulmonary vasoconstrictor response to
acute hypoxia in the endothelin B receptor deficient rat. Pediatr Res 45(4): 24A, 1999
38. Ivy DD, Parker TA, Kinsella JP, and Abman SH. Prolonged endothelin B receptor
blockade causes pulmonary hypertension in the ovine fetus. Pediatr Res 45(4): 24A,
1999
39. Parker TA, Kinsella JP, Ivy DD, and Abman SH. Pulmonary vascular effects of
prolonged estrogen receptor blockade on the response to birth related stimuli in fetal
lambs. Pediatr Res 45(4): 314A, 1999
40. Arce OX, Knudson, OA, Ivy DD, Ellison MC, and Valdes-Cruz L. Longitudinal motion
of the atrioventricular annuli in children: a heart rate independent measure of ventricular
dynamics. J Am Soc Echo 12(5): 802M, 1999
41. Shandas R, Nicol E, Weinberg C, DeGroff C, Hertzberg J, Ivy DD, and Valdes-Cruz
L. Development of a noninvasive ultrasound color M-mode means of estimating
pulmonary vascular resistance in pediatric pulmonary hypertension. J Am Coll Cardiol
35(2): 506A, 2000.
42. Boucek MM, Ivy DD, Pietra B, Shaffer EM, Sondheimer HM, Doremus TE, and
Campbell DN. Induction immunotherapy in pediatric heart transplantation: influence of
serum mycophenolate level monitoring. J Heart Lung Transplant 19(1): 84, 2000.
43. Ivy DD. Exaggerated pulmonary hypertension to prolonged hypoxia in the endothelin
B receptor deficient rat. Pediatr Res 47(4): 44A, 2000
44. Boucek MM, Sondheimer HM, Ivy DD, Shaffer EM, Mashburn C, Ripe DW, Gilbert
DJ, Kyle TE, Campbell DN, and Pietra B. Transplant coronary artery disease in
pediatrics: favorable outcome with medical therapy. J Heart Lung Transplant 20(2): 261,
2001.
45. Pietra B, Ivy DD, Sondheimer HM, Shaffer EM, Mashburn C, Ripe DW, Gilbert DJ,
Kyle TE, Mitchell MB, Campbell DN, Boucek MM. Comparison of pretransplant
transfusion with or without cyclosporin inhibition on post transplant outcome. J Heart
Lung Transplant 20(2): 222-223, 2001.
46. Resnik ER, Herron J, Fu R, Ivy DD, Cornfield DN. Hypoxia increases calciumsensitive K+ channel gene expression. Pediatr Res 49(4): 353A, 2001
47. McLaughlin VM, Sitbon O, Barst RJ, Schilz R, Robbins I, Ivy DD, Rich S. Long term
hemodynamic and exercise effects of UT-15, a subcutaneous prostacyclin analogue.
Circulation 104(17): II-249, 2001
48. The INOP I Study Group of Children’s Hospitals, (Salt Lake City, St Louis, Houston,
Kansas City, Denver, Pittsburgh, UC San Diego, Detroit, Los Angeles). Inhaled nitric
oxide as a pro-operative test: INOP Test I. Circulation 104(17): II-645, 2001
49. Barst R, Ivy DD, Widlitz AC, Moore K, Doran A, Nguyen N, Gaitonde M.
Pharmacokinetics and safety of bosentan, an oral dual endothelin receptor antagonist, in
children with pulmonary hypertension. European Heart Journal; (23):2560, 2002.
50. Ivy DD, Doran A, Kinsella JP, and Abman SH. Acute hemodynamic effects of a novel
pulsed nasal nitric oxide delivery system. Pediatr Res 51(4): 469A, 2002
28
51. Kinsella JP, Parker TA, Ivy DD, and Abman SH. Role of non-invasive delivery of
inhaled nitric oxide for late pulmonary hypertension in newborns with congenital
diaphragmatic hernia. Pediatr Res 51(4): 391A, 2002
52. Barst R, Ivy DD, Widlitz AC, Moore K, Doran A, Nguyen N, Gaitonde M.
Pharmacokinetics and safety of bosentan, an oral dual endothelin receptor antagonist, in
children with pulmonary hypertension. Circulation 106(19): II-450, 2002
53. Mitchell MB, Campbell DN, Boucek MM, Sondheimer HM, Ivy DD, Pietra BP, and
Das B. Favorable outcomes with heart transplantation for failed Fontan operation or
cavopulmonary shunt. AATS, 2003
54. Das B, Wolfe RR, and Ivy DD. Baseline pulmonary hypertension: a previously
undescribed risk factor for high altitude pulmonary edema in children. Pediatr Res 53(4):
30A, 2003
55. Giller RH, Quinones R, Ivy DD, Abman SH, Malcolm J, Coll J, Hild E, and Deterding
R. Pulmonary hypertension complicating allogeneic hemapoietic stem cell transplantation
in children and adolescents. Biology of Blood and Marrow Transplantation 9(2):74, 2003
56. Carpenter T, Schaumburg S, Colvin K, and Ivy DD. Exaggerated lung vascular leak in
endothelin B receptor deficient rats is mediated by VEGF. Am J Resp Crit Care Med
167(7): A565, 2003
57. Deterding RR, Ivy DD, Abman SH, Malcolm J, Coll J, Quinones R, and Giller RH.
Pulmonary hypertension predicts mortality in pediatric allogeneic bone marrow
transplants. Am J Resp Crit Care Med 167(7): A388, 2003
58. Barst RJ, Langleben D, Frost A, Horn E, Oudiz R, Shapiro S, McLaughlin V, Hill N,
Tapson V, Robbins I, Zwicke D, Duncan B, Frumkin L for the Stride Study Group.
Sitaxsentan, a selective ETA antagonist, improves cardiopulmonary hemodynamics in
pulmonary arterial hypertension. Am J Resp Crit Care Med 167(7): A273, 2003
59. Barst RJ, Langleben D, Frost A, Horn E, Oudiz R, Shapiro S, McLaughlin V, Hill N,
Tapson V, Robbins I, Zwicke D, Duncan B, Frumkin L for the Stride Study Group.
Sitaxsentan, a selective ETA antagonist, improves exercise capacity and NYHA
functional class in pulmonary arterial hypertension. Am J Resp Crit Care Med 167(7):
A440, 2003
60. Miyamoto SD, Pietra BA, Chan KC, Ivy DD, Mashburn C, Campbell DN, Mitchell MB,
Boucek MM. Successful cardiac transplantation following interventional palliation in
patients with hypoplastic left heart syndrome. Circulation 108(17): IV-495, 2003
61. Pietra BA, Mashburn C, Gilbert D, Legette F, Ivy DD, Sondheimer HM, Mitchell MB,
Campbell DN, Boucek MM. Early management in transplantation for HLHS leads to
infrequent rejection and improved survival. Circulation 108(17): IV-330, 2003
62. AA Condino, JA O’Connor, MR Narkewicz, L Claussen, A Doran, Ivy DD, RJ Sokol.
Portopulmonary hypertension in pediatrics: a case series. J Pediatr Gastroenterol Nutr,
2004, 39, supplement 1, S11-12
63. Dyer KL, Pauliks L, Kirby SK, Claussen L, Ivy DD, Shandas R, Valdes-Cruz L.
Myocardial performance index in pediatric patients with primary pulmonary hypertension:
correlation with pulmonary artery pressure and response to vasodilators. J Am Coll
Cardiol 43(5): 388A, 2004
64. Yetman AT, Taylor A, Ivy DD. Exercise responses in children with pulmonary
hypertension. J Am Coll Cardiol 43(5): 392A, 2004
65. Ivy DD, Rosenzweig EB, Widlitz AC, Doran AK, Claussen LR, Yung D, Abman SH,
Barst RJ. Effects of long-term bosentan in children with pulmonary arterial hypertension.
Am J Resp Crit Care Med 169(7): A210, 2004
29
66. Mourani PM, Ivy DD, Gao D, and Abman SH. Pulmonary vascular reactivity in
children and adolescents with bronchopulmonary dysplasia. Am J Resp Crit Care Med
169(7): A169, 2004
67. Das BB, Lanning C, Dyer KL, Ivy DD, Valdes-Cruz L, Shandas R. Evaluation of
pulmonary artery pulsatility in pulmonary hypertension using color m-mode tissue Doppler
imaging in infants and children. Pediatr Res 55(4): 51A, 2004
68. Dyer KL, Das BB, Lanning C, Ivy DD, Valdes-Cruz L, Shandas R. Noninvasive tissue
Doppler measurement of pulmonary artery compliance in children with pulmonary
hypertension. Pediatr Res 55(4): 39A, 2004
69. Yetman AT, Taylor AL, Wolfe RR and Ivy DD. Correlation between maximal and
submaximal exercise capacity in young patients with pulmonary arterial hypertension.
Presented at the North American Society for Pediatric Exercise Medicine 2004 Biennial
Meeting. St Andrews, New Brunswick, Canada, 2004
70. Frost A, Ivy DD. Sitaxsentan for pulmonary arterial hypertension patients with clinical
deterioration or significantly abnormal liver function test on Bosentan. Am J Resp Crit
Care Med 2: A204, 2005
71. Kaufman J, Ivy DD, Jones PL, McMurtry IF, Gebb SA. The role of Rho GTPases in
maintenance of fetal lung lipofibroblast phenotype. Am J Resp Crit Care Med 2: A464,
2005
72. Miyamoto SD, Pietra BP, Chan KC, Ivy DD, Mashburn C, Campbell DN, Mitchell MB,
Boucek MM. Normal pulmonary arterial development following transplantation in patients
with hypoplastic left heart syndrome who were palliated with internal pulmonary artery
bands. Cardiology in the Young 15(2): O18-5, 21, 2005
73. Ivy DD, Frost A. Sitaxsentan for pulmonary arterial hypertension patients with clinical
deterioration or significantly abnormal liver function test on Bosentan.,
World Congress of Pediatric Cardiology, Buenos Aires, Argentina, September 18-22,
2005
74. Ivy DD, Barst RJ for the Stride-2 Study Group. Sitaxsentan for the treatment of
pulmonary arterial hypertension. World Congress of Pediatric Cardiology, Buenos Aires,
Argentina, September 18-22, 2005
75. Pauliks LB, Dyer KD, Shaffer EM, Ivy DD, Valdes-Cruz LM. Myocardial acceleration
during isovolumic contraction in children with pulmonary hypertension: a tissue Doppler
study and correlation with catheterization data. Circulation, 112:17 (Supp II): II-764, 2005
76. Imamura M, Vitello AM, Limbird JN, Ivy DD, Fallon MB, Carter EP.
Endothelin-B receptor overexpression prevents hypoxic pulmonary hypertension in
cirrhotic rats. Chest 2005 Dec; 128(6 Suppl):580S-1S, 2005
77. Ihida-Stansbury K, McKean DM, Gebb SA, Martin JF, Stevens T, Nemenoff R,
Vaughn J, Lane K, Loyd J, Wheeler L, Morrell NW, Ivy DD, Jones PL. Regulation and
Functions of the Paired-Related Homeobox Gene PRX1 in Pulmonary Vascular
Development and Disease. Chest Dec; 128(6 Suppl):591S, 2005
78. Beghetti M, Ivy DD, Barst RJ. Clinical experience with Bosentan in children with
pulmonary arterial hypertension. Eur J Clinical Investigation: 35(Supplement 2):58, 2005
79. Dyer KL, Pauliks LB, Shaffer EM, Ivy DD, and Valdes-Cruz LM. Peak systolic strain
and strain rate in children with pulmonary hypertension: a tissue Doppler study and
correlation with cardiac catheterization. J Am Coll Cardiol 47(4): 306A, 2006
80. Darst JR, Ivy DD, and Chan KC. Pulmonary vein stenosis presenting as pulmonary
hypertension: short and medium term outcome after stent implantation. Cardiology in the
Young, 16 (2): 85, 2006
30
81. Bernus A, Chan KC, Doran A, Claussen L, Taylor A, Kay J, Ivy DD. Brain Natriuretic
Peptide as a Predictive Marker of Right Ventricular Dysfunction and Clinical Worsening in
Pediatric Patients with Pulmonary Arterial Hypertension. Cardiology in the Young, 16 (2):
93, 2006
82. Zhang Y, Hunter KS, Lanning C, Ivy DD, Claussen L, and Shandas R. A
microstructural model applied to 3D patient-specific images of the pulmonary vasculature:
prediction of structural remodeling in PAH. Proceedings of the American Thoracic Society
3: A60, 2006
83. Richman AP, Stenmark KR, Ivy DD, Hofmeister SE, Iglarz M, and Davie NJ. The
endothelin receptor antagonist bosentan, attenuates hypoxia-induced angiogenesis in the
pulmonary artery vaso vasorum microcirculation. Proceedings of the American Thoracic
Society 3: A754, 2006
84. Vaughn JJ, Colvin KL, Crossno JT, Ivy DD, Stenmark K, and Davie NJ. Potential role
of bone marrow-derived mesenchymal stem cells in remodeling / repair of the lung
response to hypoxia. Proceedings of the American Thoracic Society 3: A755, 2006
85. Colvin KL, Duncan MW, Edwards MG, Hunsucker SW, Davie NJ, and Ivy DD. The
plasma proteome of children with idiopathic pulmonary arterial hypertension: comparison
between responders and non-responders to vasodilator therapy. Proceedings of the
American Thoracic Society 3: A512, 2006
86. Rosenzweig EB, Ivy DD, Widlitz AC, Doran AK, Claussen LR, Yung D, Abman SH,
and Barst RJ. Impact of bosentan in children with pulmonary arterial hypertension related
to congenital heart disease. European Society of Cardiology, 2006
87. Ivy DD, Doran AK, Parker DK, Claussen LR, Smith KJ, Mallory GB, and Abman SH.
Acute and chronic effects of inhaled iloprost therapy in children with pulmonary arterial
hypertension. Chest: 130(4): 156S, 2006
88. Smith KJ, Mallory GB, Abman SH, and Ivy DD. Airway hyperreactivity after iloprost
inhalation in pediatric patients with pulmonary arterial hypertension Chest: 130(4): 156S,
2006
89. Buckvold S, Tissot-Daguette C, Phelps CM, Mitchell MB, Campbell DN, Ivy DD,
Pietra BA, Miyamoto SD. Primary heart transplantation for hypoplastic left heart
syndrome: effect of waiting time on pulmonary artery pressure. Pediatric Critical Care
Medicine: 8(3): A242, 2007
90. Tissot-Daguette C, Buckvold S, Phelps CM, Ivy DD, Campbell DN, Mitchell MB,
Pietra BA, Miyamoto SD. Use of ECMO to reverse primary graft failure after heart
transplantation in children. Pediatric Critical Care Medicine: 8(3): A279, 2007
91 Phelps CM, Tissot-Daguette C, Buckvold S, Ivy DD, Pietra BA, Miyamoto SD.
Inotropic and mechanical support in acute graft rejection for pediatric heart transplant
patients. Pediatric Critical Care medicine: 8(3): A282, 2007
92. Beghetti M, Haworth SG, Barst RJ, Jais X, Acar P, Fraisse A, Ivy DD,
Schulze-Neick I, Bonnet D, Berger RMF. Pharmacokinetics and safety profile of
a novel formulation of bosentan in children with pulmonary arterial hypertension
(PAH): FUTURE-1 study. European Heart Journal : 28(Supplement 1): 150, 2007
93. Beghetti M, Doran AK, Mallory G, Barst RJ, Law Y, Abman SH, Ivy DD.
Inhaled iloprost therapy in children with pulmonary arterial hypertension.
Cardiology in the Young, 17 (1): 78, 2007
94. Tissot C, Pietra BA, Boucek MM, Gilbert DJ, Campbell DN, Mitchell MB, Ivy DD,
Miyamoto SD. Coronary flow reserve can detect progressive transplant coronary
artery disease in pediatric heart transplant recipients. Cardiology in the Young, 18
Suppl 1: 29, 2008
31
95. Tissot C, Pietra BA, Boucek MM, Gilbert DJ, Campbell DN, Mitchell MB, Ivy DD,
Miyamoto SD. Early diagnosis of transplant coronary artery disease by intravascular
ultrasound improves the outcome of pediatric heart transplant recipients. Cardiology
in the Young, 18 Suppl 1: 88, 2008
96. Tissot C, Pietra BA, Boucek MM, Ripe DW, Mashburn C, Campbell DN, Mitchell
MB, Ivy DD, Miyamoto SD. Long-term outcome of pediatric heart transplant recipients
from donation after cardiac death. Cardiology in the Young, 18 Suppl 1: 52, 2008
97. Berger RMF, Beghetti M, Barst RJ, Jais X, Acar P, Fraisse A, Ivy DD, SchulzeNeick I, Bonnet D, Galie N, Haworth SG. Effect on quality of life and other subjective
parameters of a novel formulation of bosentan in children with pulmonary arterial
hypertension: FUTURE-1 study. Cardiology in the Young, 18 Suppl 1: 19, 2008
98. Ivy DD, Barst RJ, Doran AK, Lemarie JC, Brand M, Rosenberg D, Rosenzweig
EB. Effects of Long-Term Bosentan in Children with Pulmonary Arterial Hypertension.
Cardiology in the Young, 18 Suppl 1: 34, 2008
99. Barst RJ, Ivy DD, Badesch D, Benza R, Elliott G, Farber H, Frost A, Krichman A,
Liou T, Raskob G, Giles S, Feldkircher K, Turner M, McGoon M. Reveal Registry:
treatment at Baseline for patients with childhood-onset pulmonary arterial
hypertension. American Academy of Pediatrics, 2008
100. Tissot C, Pietra BA,
Boucek MM, Diamond BA, Buckvold S, Campbell DN, Mitchell MB, Ivy DD, Miyamoto
SD. Coronary artery flow reserve is lower at the time of transplant coronary artery
disease diagnosis in children transplanted in infancy. Scientific Basis of Heart Failure
in Children, American Heart Association, Estes Park, CO, 2008
101. Mourani PM, Sontag M, Lui G, Ivy DD, and Abman SH. Sildenafil therapy for
pulmonary hypertension in infants with chronic lung disease.
Ped Res 169(7): A169, 2008
102. Barker AJ, Lanning C, Hunter K, Ivy DD and Shandas R. Artery dilatation in
pediatric pulmonary hypertension patients decreases hemodynamic wall shear stress.
Circulation, 118(18) Suppl 2: S879, 2008
103. Hunter K, Lanning C, Kirby KS, Ivy DD and Shandas R. In-vivo pulmonary vascular
stiffness obtained from color m-mode tissue Doppler imaging and pressure
measurements predicts clinical outcomes better than indexed pulmonary vascular
resistance in pediatric patients with pulmonary hypertension. Circulation, 118(18) Suppl
2: S879, 2008
104. Stoica S, Clarke D, Kozik D, Goldberg S, Campbell D, Twite M, da Cruz E,
Younoszai A, Fagan T, Ivy DD, Lacour-Gayet F. Morbidity factors in the arterial
switch operation. Cardiology in the Young 19(Suppl. 2), 149, 2009
105. Tissot C, Pietra BA, Boucek MM, Gilbert DJ, Campbell DN, Mitchell MB, Ivy
DD, Miyamoto SD. Coronary flow reserve can differentiate stable from
progressive transplant coronary artery disease in pediatric heart transplant
recipients. Cardiology in the Young 19(Suppl. 2), 156, 2009.
106. Tissot C, Pietra BA, Boucek MM, Gilbert DJ, Campbell DN, Mitchell MB, Ivy
DD, Miyamoto SD. Early diagnosis of transplant coronary artery disease by
intravascular ultrasound (IVUS) improves the outcome of pediatric heart
transplant recipients. Cardiology in the Young 19(Suppl. 2), 158, 2009.
107. Barst RJ, Ivy DD, Badesch DB, Benza RL, Elliott CG, Farber HW, Frost AE,
Krichman A, Liou TG, Raskob GE, Wason P, Feldkircher K, Foreman AJ,
McGoon M. REVEAL Registry: Comparison of patients with childhood-onset and
adult-onset idiopathic pulmonary arterial hypertension. The Journal of Heart and
32
Lung Transplantation, Volume 28, Issue 2, Supplement 1, S146:A228, 2009
108. Barst RJ, Ivy DD, Badesch DB, Benza RL, Elliott CG, Farber HW, Frost AE,
Krichman A, Liou TG, Raskob GE, Wason P, Feldkircher K, Foreman AJ,
McGoon M. REVEAL Registry: Pediatric IPAH versus pediatric pulmonary
vascular disease associated with congenital heart disease. The Journal of Heart
and Lung Transplantation, Volume 28, Issue 2, Supplement 1, S203:A397, 2009
109. Barst RJ, Ivy DD, Badesch DB, Benza RL, Elliott CG, Farber HW, Frost AE,
Krichman A, Liou TG, Raskob GE, Wason P, Feldkircher K, Foreman AJ,
McGoon M. REVEAL Registry: Comparison of patients with childhood-onset and
adult-onset pulmonary vascular disease associated with congenital heart
disease. The Journal of Heart and Lung Transplantation, Volume 28, Issue 2,
Supplement 1, S3126:A708, 2009
110. Barst RJ, Foreman AJ, Ivy DD, McGoon MD. REVEAL Registry: One year outcome
of patients with congenital heart disease-associated pulmonary arterial hypertension
(CHD-APAH). Am. J. Respir. Crit. Care Med., 179:A2656, 2009
111. Howley LW, Fonseca B, Sigur C, Ivy DD, Shaffer E, Younoszai A. Abnormal systolic
septal curvature and diastolic dysfunction predict moderate pulmonary arterial
hypertension in children. Journal of the American Society of Echocardiography, 22(5);
551:P1-20, 2009
112. Howley LW, Fonseca B, Sigur C, Ivy DD, Younoszai A. Bi-ventricular diastolic
dysfunction by Doppler tissue imaging correlates with invasive markers of pulmonary
hypertension in children. Journal of the American Society of Echocardiography, 22(5);
552:P1-21, 2009
113. Barst RJ, Foreman AJ, Ivy DD, McGoon MD. REVEAL Registry: Two year
outcome of patients with congenital heart disease-associated pulmonary arterial
hypertension (CHD-APAH). European Heart Journal: 30(Supplement 1):
259:P1578, 2009
114. Beghetti M, Berger RMF, Barst RJ, Jais X, Acar P, Fraisse A, Ivy DD,
Schulze-Neick I, Bonnet D, Haworth SG. BOS1987 Longer-term survival in
paediatric patients with idiopathic or familial pulmonary arterial hypertension
(IPAH/FPAH) treated with bosentan: data from the FUTURE-1 and FUTURE-2
studies European Heart Journal: 30(Supplement 1): 900:5176, 2009
115. Tissot C, Pietra BA, Boucek MM, Gilbert DJ, Campbell DN, Mitchell MB, Ivy
DD, Miyamoto SD. Transplant coronary artery disease is diagnosed later and is
more severe in pediatric heart recipients transplanted in infancy Swiss Pediatric
Society Congress, 2009
116. Tissot C, Pietra BA, Ivy DD, Mitchell MB, Campbell DN, Gilbert DJ,
Miyamoto SD. Pediatric Heart Transplant Recipients with Transplant Coronary
Artery Disease show a steady increase in Filling Pressures over Time. The
Journal of Heart and Lung Transplantation, Volume 29, Issue 2, Supplement 1,
Page S170, 2010
117. Tissot C, Pietra BA, Ivy DD, Campbell DN, Mitchell MB, Diamond B,
Miyamoto SD. Asymptomatic rejection diagnosed by surveillance
endomyocardial biopsy in pediatric heart transplant recipients: Do we need to
treat? The Journal of Heart and Lung Transplantation, Volume 29, Issue 2,
Supplement 1, Pages S171-S172, 2010
118. Al-Naami GH, Landeck II B, Ivy DD, Younoszai A. The RV/LV end systolic
and systolic/diastolic time interval ratios: quick and easy echocardiographic tools
33
for pulmonary hypertension assessment in a pediatric clinic.3rd International
Conference on Neonatal and Childhood Pulmonary Hypertension. Banff,
Canada, 2010
119. Al-Naami GH, Landeck II B, Ivy DD, Younoszai A. Altered Right Ventricular
Longitudinal Deformation is seen in Children with Pulmonary Hypertension: A
Study of Myocardial Strain and Strain Rate by Speckle Tracking. 3rd International
Conference on Neonatal and Childhood Pulmonary Hypertension. Banff,
Canada, 2010
120. Al-Naami GH, Landeck II B, Ivy DD, Younoszai A. Rotational left ventricular
mechanics are affected in children with pulmonary hypertension. Journal of the American
Society of Echocardiography, 2010
121. Ivy DD, Rosenzweig EB, Calderbank M, Coleman B, Miller-Reed K, and
Geppner J. Pharmacokinetics And Safety Of Ambrisentan In Pediatric Patients
With Pulmonary Arterial Hypertension . Am. J. Respir. Crit. Care Med. 181:
A3330, 2010
122. Yeager ME, Nguyen CM, Colvin KC, Ivy DD, and Stenmark KR .Evidence
Of Neo-Lymphangiogenesis In Severe Pulmonary Artery Hypertension Am J
Respir Crit Care Med 181: A6291, 2010
123. Colvin KM, Nguyen CM, Ivy DD, Stenmark KR, and Yeager ME
The Unfolded Protein Response Is Activated In Severe Pulmonary Artery
Hypertension Am J Respir Crit Care Med 181: A5234, 2010
124. Belchenko DD, Colvin KM, Nguyen CM, Ivy DD, Stenmark KR, and Yeager
ME. High Levels Of Endothelin-1 Induce The Unfolded Protein Response In
Pulmonary Artery And Microvascular Endothelium. Am J Respir Crit Care Med
181: A5235, 2010
125. Vezmar M, Malhotra SP, Zhou Z, Yu XY, Abadilla A, Rausch C, Rutledge J,
Rebeyka I, McCrindle B, Cai S, Lacour-Gayet F, Ivy DD, Li J. Altitude is not a
risk factor for patients undergoing bidirectional cavopulmonary anastomoses and
Fontan operation: A comparative study between Denver, Edmonton and Toronto.
Circulation 122: A15611, 2010
126. Barst RJ, Ivy DD, Badesch D, Benza R, Elliott CG, Farber H, Frost A, Poms
A, Liou T, Raskob GE, Watson P, Feldkircher K, Foreman AJ, and McGoon MD.
REVEAL Registry: Comparison of Patients with Childhood-Onset and AdultOnset Pulmonary Vascular Disease Associated with Congenital Heart Disease.
Pediatr Res 33 (4): E-PAS2011:2928.323
127. Barst RJ, Ivy DD, Badesch D, Benza R, Elliott CG, Farber H, Frost A, Poms
A, Liou T, Raskob GE, Watson P, Feldkircher K, Foreman AJ, and McGoon MD.
REVEAL Registry: Comparison of Patients with Childhood-Onset and AdultOnset Idiopathic Pulmonary Arterial Hypertension. Pediatr Res EPAS2011:2928.324
128. Barst RJ, Ivy DD, Elliott CG, Watson P, Foreman AJ, Miller DP, and
McGoon MD. Childhood Pulmonary Arterial Hypertension: Insights from the
REVEAL Registry. Pediatr Res E-PAS2011:2928.325
129. Barst RJ, Humpl T, Schulze-Neick I, Raskob GE, Ivy DD, Jing Z-C, Bonnet
D, M Beghetti M and Berger RMF on Behalf of the TOPP Study Group. TOPP:
Clinical Features of Pediatric Pulmonary Hypertension in an International
Registry. Pediatr Res E-PAS2011:3645.1
130. Yeager ME, Colvin KL, Belchenko DD, Nega M, Barajas C, Cripe PJ, Ivy DD,
34
Stenmark K. Immunologically Active And Well-Vascularized Bronchus-Associated
Lymphoid Tissue Is Evident In Pulmonary Hypertension. Am J Respir Crit Care Med 181:
A1325, 2011
131. Burgett Graves SL, Lanning C, Kirby KS, Calderbank M, Geppner J, Nolan SJ,
Ivy DD, Shandas R, Hunter K. In-Vivo Pulmonary Vascular Stiffness Obtained From
Color M-Mode Tissue Doppler Imaging And Pressure Measurements Predicts Clinical
Outcomes Better Than Indexed Pulmonary Vascular Resistance In Pediatric Patients
With Pulmonary Arterial Hypertension. Am J Respir Crit Care Med 181: A5748, 2011
132. Takatsuki S, Calderbank M, Ivy DD. Initial Experience with Tadalafil In Pediatric
Pulmonary Arterial Hypertension. Am J Respir Crit Care Med 181: A5897, 2011
133. Hale BW, Kirby KS, Calderbank M, Geppner J, Ivy DD, Shandas R, Hunter K.
Comparison Of Pulmonary Vascular Input Impedance And Pulmonary Vascular
Resistance To Model Clinical Outcomes In Pediatric Patients With Pulmonary Arterial
Hypertension. Am J Respir Crit Care Med 181: A5928, 2011
134. Rosenzweig EB, Krishnan U, Takatsuki S, Kerstein J, Calderbank M, D.D. Ivy DD.
Inhaled Treprostinil In Pediatric Pulmonary Arterial Hypertension. Am J Respir Crit Care
Med 181: A6134, 2011
135. Maxey D, Ivy DD, Ogawa M, Feinstein J. Adverse And Significant Adverse Events
Associated With Pulmonary Hypertension Therapy In Pediatric Patients: An FDA PostMarket Study Am J Respir Crit Care Med 181: A5891 , 2011
136. Siehr SL, Ivy DD, Miller-Reed K, Ogawa M, Rosenthal D, and Feinstein JA.
Longitudinal hemodynamic changes in pediatric patients with severe pulmonary arterial
hypertension on prostanoid therapy. The Journal of Heart and Lung Transplantation. 30:
A197, 2011
137. Berger RMF, Humpl T, Schulze-Neick I, Raskob G, Ivy DD, Jing ZC, Bonnet D,
Beghetti M, Barst RJ. Pediatric pulmonary hypertension: insights from the Tracking
Outcomes and Practice in Pediatric Pulmonary Hypertension (TOPP) global registry. Eur
Heart Journal, 2011
138. Barst RJ, Konourina I, Watt S, Richardson H, Layton G, Ivy DD.
Pediatric Pulmonary Arterial Hypertension: Sildenafil Monotherapy for One Year
in Treatment-Naïve Children . Eur Resp Journal, 2011
139. Jone P, Howley LW, Hinzman J, Ivy DD, Younoszai A.
Bi-ventricular diastolic function by tissue Doppler imaging correlates with severity
of pulmonary hypertension in children . Cardiology in the Young 21(Suppl. 1),
S117, 2011
140. Berger RMF, Humpl T, Schulze-Neick I, Raskob G, Ivy DD, Jing ZC, Bonnet
D, Beghetti M, Barst RJ. Clinical characteristics of pediatric pulmonary
hypertension: results from the global registry Tracking Outcomes and Practice in
Pediatric Pulmonary Hypertension (TOPP). Cardiology in the Young 21(Suppl.
1), S124, 2011
141. Barst RJ, Russell SD, Oudiz RJ, Ivy DD, Layton G, Konourina I, Watt S
Effects of Oral Sildenafil Treatment on Exercise Capacity in Pediatric Pulmonary
Arterial Hypertension. Chest 140(4),396A,2011
142. Barst RJ, Ivy DD, Frantz B, Frost A, Rosenzweig EB, Foreman A, Shapiro S,
Taichman D, McGoon M. Impact of Functional Class Change on Survival in
Patients With Pulmonary Arterial Hypertension Associated With Congenital Heart
Disease: Insights From REVEAL. Chest 140(4),716A,2011
35
143. Taylor AL, Ivy DD, and Rausch C. VE/VCO2 Slope And Functional Class In
Pediatric Pulmonary Arterial Hypertension. Am J Respir Crit Care Med 185:
A1903, 2012
144. De A, Coleman B, Ivy DD, Yaron M, Ward SD. A Rare And Interesting Case
Of Syncope At Altitude. Am J Respir Crit Care Med 185: A3384, 2012
145. Barst RJ, Ivy DD, Rosenzweig EB, Foreman AJ, Turner M, Meltzer LA, and McGoon
MD. Characteristics And Four-Year Outcomes Of Patients With Eisenmenger Syndrome
In REVEAL. Am J Respir Crit Care Med 185: A4793, 2012
146. Burgett SL, Kirby KS, Calderbank M, Ivy DD, and Hunter KS. Diameter Of
The Pulmonary Artery Measured With Color M-Mode Tissue Doppler Imaging
Predicts Clinical Outcomes Better Than Indexed Pulmonary Vascular Resistance
In Pediatric Patients With Pulmonary Arterial Hypertension Am. J. Respir. Crit.
Care Med. 185: A6739, 2012
147. Barst RJ, Layton GR, Konourina I, Richardson H, Beghetti, Ivy DD. STARTS-2:
long-term survival with oral sildenafil monotherapy in treatment-naïve pediatric pulmonary
arterial hypertension. Eur Heart Journal 33(Suppl 1): P5340, 2012
148. Loloyan S, Barst RJ, Brown L, Ivy DD, Rosenzweig EB, Lai G, Elliott CG,
Szmuszkovic J, Oudiz R. Time to Recognition of Pediatric Pulmonary Arterial
Hypertension: Factors Identified From the REVEAL Registry. Chest
142(4):824A, 2012
149. Barst RJ, Humpl T, Schulze-Neick I, Jing ZC, Levy M, Ivy DD, Bonnet D, Kronmal D,
Beghetti M, Berger RMF. Outcomes Of Pulmonary Hypertension (PH) In Childhood:
Results From The Global TOPP Registry. Am J Respir Crit Care Med 187;A2089,2013
150. Beghetti M, Zhang M, Ivy DD, Barst RJ. Oral Sildenafil in Children With Down
Syndrome and Pulmonary Arterial Hypertension. Am J Respir Crit Care Med
187;A2091,2013
151. Oudiz RJ, Russell SD, Zhang M, Ivy DD, Barst RJ, Beghetti M. Effects of Oral
Sildenafil Treatment on Exercise Capacity in Children With Pulmonary Arterial
Hypertension. Am J Respir Crit Care Med 187;A2092,2013
152. Takatsuki S, Naoi K, Ikehara S, Nakayama T, Matsuura H, Ivy DD, Saji T.
Pulmonary arterial capacitance index can predict adverse outcome in children with
idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 187;A2537,2013
153. Hobson N, Ivy DD, Hunter K. Modified Single-Beat Method For The
Estimation Of Ventricular-Arterial Coupling Ratio In The Right Ventricle For Use
As A Prognostic In Pediatric Pulmonary Hypertension. Am J Respir Crit Care
Med 187;A2543,2013
154. Nathan SD, Hansdottir S, Feldman J, Ishizawar D, Ivy DD, Schilz R,
Shapiro S, White RJ. Safety And Feasibility Of Switching Between Oral And
Parenteral Treprostinil. Am J Respir Crit Care Med 187;A3276,2013
155. Zijlstra WMH, Douwes JM, Rosenzweig EB, Schokker S, Krishnan U, Roofthooft
MTR, Miller-Reed K, Hillege HL, Ivy DD, Berger RMF. Transatlantic survival differences in
pediatric pulmonary arterial hypertension: clues to a better understanding of disease
characteristics and treatment. Am J Respir Crit Care Med 187;A3285,2013
156. Berger RMF, Haworth SG, Bonnet D, Acar P, Fraisse A, Galié N, Ivy DD,
Jais , Miera O, Rosenzweig EB, Efficace M, Kusic-Pajic A, Beghetti M.
Results from an open-label, long-term safety and tolerability extension study using the
pediatric FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion (FUTURE-2).
Association for European Pediatric Cardiology, 23;S1:PW1-7,2013
36
157. Hauck A, Ivy DD, Younoszai A. Tricuspid Annular Plane Systolic Excursion
Correlates with Maximal Exercise Testing but Not Six-Minute Walk Distance in
Pediatric Pulmonary Hypertension. Journal of the American Society of
Echocardiography 26(6), B118, 2013
158. DiMaria M, Landeck B, Younoszai A, Mertens L, Ivy DD, Hunter K,
Friedberg M. Echocardiographic estimation of right ventricular stroke work in
children with p: comparison to invasive measurements. Journal of the American
Society of Echocardiography 26(6), B5, 2013
159. Zijlstra WMH, Douwes JM, Rosenzweig EB, Schokker S, Krishnan U,
Roofthooft MTR, Miller-Reed K, Hillege JL, Ivy DD, Berger RMF. Children with
pulmonary arterial hypertension (PAH) associated with congenital heart disease
are treated less intensively with PAH-targeted drugs compared to children with
idiopathic/hereditary PAH. Eur Heart Journal 34(Suppl 1): P304, 2013
160. Douwes JM, Barst RJ, Humpl T, Beghettit M, Bonnet D, Schulze-Neick I, Ivy
DD, Berger RMF. Acute vasodilator response in paediatric pulmonary arterial
hypertension: current clinical practice from the TOPP-registry. Cardiology in the
Young 24(Suppl. 1), S18, 2014
161. Takatsuki S, Naoi K, Ikehara S, Nakayama T, Matsuura H, Ivy DD, Saji T. Serial
assessment of pulmonary arterial capacitance index during midterm follow-up predicts
adverse outcomes in children with idiopathic pulmonary arterial hypertension. Am J
Respir Crit Care Med 189;A3252,2014
162. Yeager ME, Colvin KL, Ivy DD, Bull TM, Stenmark KR. Reduced phagocytic capacity
drives experimental pulmonary hypertension. Am J Respir Crit Care Med
189;A3355,2014
163. Yeager ME, Colvin KL, Ivy DD, Stenmark KR. Cardiopulmonary lymphatic vessel
dynamics and development of right ventricular edema in experimental pulmonary
hypertension. Am J Respir Crit Care Med 189;A5551,2014
164. Di Maria M, Fagan T, Wilson N, Mitchell M, Campbell D, Jaggers J, da Cruz EM, Ivy
DD, Younoszai A. Pre-Superior cavopulmonary anastomosis cardiac catheterization at
altitude. Circulation 130:A19807, 2014
165. Agyei-Ntim F, Hunter K, Truong U, Ivy DD, Shandas R. Statistical Shape
Modeling of the Right Ventricle Differentiates Stages of RV Remodeling in
Children With Pulmonary Hypertension: An Initial Analysis
Circulation 130:A15746, 2014
166. Colvin KL, Lohani O, Williams SM, Ivy DD, Stenmark K, Yeager M. Right
Ventricle Lymphatic Vessel Insufficiency Contributes to Interstitial Fluid Stasis,
Inflammation, Fibrosis, and Failure in Pulmonary Hypertension
Circulation 130:A11636, 2014
Administrative Positions
Fellowship Director, Pediatric Cardiology
Director, Pediatric Pulmonary Hypertension Program
Chief, Pediatric Cardiology
Interim Director, Cardiac ICU
Teaching and Mentoring
Physiology 5000 – Clinical Correlates
First year medical students
Pediatrics 7000
1996-2001
1997 to present
2003 to present
2006 to 2007
2001-2003
1994 to present
37
Third year medical students
Core Lecture Series
Pediatric residents
Pediatric Academic Track
Mentor pediatric residents
Fellowship Director
Mentorships
Direct Pediatric resident teaching and supervision
Direct Pediatric Cardiology fellow teaching and supervision
Pediatric Resident Research Mentor
Conrad Epting, MD
Kirsten Bourke, MD
Eric Austin, MD
Pediatric Cardiology Fellow Research Mentor
Dennis Chang, MD
Bibhuti Das, MD
Anna Bernus, MD
Jane Nydam, MD
Pediatric Faculty Pulmonary Hypertension Mentor
Shinichi Takatsuki, MD
Erika Harder, MD
1994 to present
1998 to present
1996-2001
1994 to present
1994 to present
1998-2000
1999-2002
2002-2004
2002-2004
2002-2003
2004-2007
2005-2008
2010-2012
2013
PhD Advisor
Craig Weinberg, BS
2000-2003
Ph.D. Thesis “Ultrasound evaluation of the pulmonary vascular resistance,
input impedance, and right ventricular power in children with pulmonary
hypertension”
Dong Seok Lee, MD, PhD
2003-2004
Post-doctoral fellow
Endothelin in a novel model of pulmonary hypertension
Alex Barker, BS
2007-present
Wall stress as determined by cardiac MRI in patients with pulmonary arterial
hypertension
Masters Advisor
Nick Hobson, MS
2011-2012
Utility of single beat measurement of ventricular vascular coupling in children
with pulmonary arterial hypertension
Clinical Trials
1. An international, multicenter, randomized, placebo controlled trial of chronic
UT-15 (Uniprost) in patients with pulmonary hypertension, United
Therapeutics, 1999-2000, Co-Investigator
2. An international, multicenter, uncontrolled, open evaluation of chronic UT-15
(Uniprost) plus conventional therapy in patients with pulmonary hypertension,
United Therapeutics, 1999-2002, Co-Investigator
3. A double-blind, randomized, placebo-controlled study to assess the effects of
38
R0 47-0203 (bosentan) on exercise capacity in patients with pulmonary arterial
hypertension. Actelion, 2000-2001, Co-Investigator
4. Prophylactic use of primacor in pediatric patients at high risk of developing low
cardiac output syndrome following cardiac surgery, Sanofi-Synthelabo, 2000-2001,
Co-Investigator
5. A double-blind, randomized, placebo-controlled safety and efficacy study
of sitaxsentan sodium treatment in patients with pulmonary arterial
hypertension, ICOS-Texas Biotechnology Corporation, 2001-2002, Co-Investigator
6. A multicenter study to evaluate efficacy, safety, and pharmacokinetics of Brevibloc
(Esmolol) for the treatment of hypertension in infants and children after surgical repair of
coarctation of the aorta, 2001-2002, Co-Investigator
7. A study to investigate the pharmacokinetics and tolerability of bosentan and its
metabolites when bosentan is given as single and multiple oral doses in
children with pulmonary arterial hypertension, Actelion, 2001-2002, Co-Investigator
8. Development of a hospital-based home program for the use of inhaled nitric oxide in
the chronic management of severe cardiopulmonary diseases
I-NOTherapeutics, 2005-present, Co-Investigator
9. A randomized, multicenter, double-blind, placebo-controlled, dose-ranging, parallel
group study of intravenous sildenafil in the treatment of children, aged 0 to 17 with
pulmonary hypertension after corrective cardiac surgery, 2003-2005, Co-Investigator
10. A randomized, multicenter, double-blind, placebo-controlled, dose-ranging, parallel
group study of oral sildenafil in the treatment of children, aged 1 to 16 years, with
pulmonary arterial hypertension, 2003-present, Co-Investigator
11. A phase III, randomized, double-blind, placebo-controlled safety and efficacy
study of sitaxsentan sodium treatment with an open-label bosentan arm in patients with
pulmonary arterial hypertension, Encysive, 2003-2006, Co-Investigator
12. A double-blind safety and efficacy study of sitaxsentan sodium treatment in patients
with pulmonary arterial hypertension who have failed bosentan therapy, Encysive, 20032006, Co-Investigator
13. A long-term, open-label study to evaluate the safety of sitaxsentan sodium treatment
in patients with pulmonary arterial hypertension, Encysive, 2003-present, Co-Investigator
14. STEP: A double-blind placebo controlled study to evaluate the efficacy and safety of
iloprost in combination with bosentan in subjects with pulmonary arterial hypertension,
CoTherix, 2004-2006, Co-Investigator
15. A randomized, double-blind, placebo controlled phase 3 study of the
phosphodiesterase type 5 (PDE5) inhibitor tadalafil in the treatment of patients with
pulmonary arterial hypertension, 2005-present, Co-Investigator
16. FUTURE 1: an open label, multicenter study to assess the pharmacokinetics,
tolerability, and safety of a pediatric formulation of bosentan in children with idiopathic
pulmonary arterial hypertension, 2005-present, Co-Investigator
17. A 16-week, international , multicenter, double-blind, randomized, placebo-controlled
comparison of the efficacy and safety of oral UT-15C sustained release tablets in
combination with an endothelin receptor antagonist and/or a phosphodiesterase-5
inhibitor in subjects with pulmonary arterial hypertension, 2006-present, Co-Investigator
18. Randomized, placebo-controlled, double-blind, multicenter, parallel group study to
assess the efficacy, safety, and tolerability of Bosentan in patients with symptomatic
pulmonary arterial hypertension (ASSET 1) or pulmonary hypertension associated with
sickle cell disease (ASSET 2), 2006-2009, Co-Investigator
39
19. A 16-week, international, multicenter, double-blind, randomized, placebo-controlled
comparison of the efficacy and safety of oral UT-15C sustained release tablets in
combination with an endothelin receptor antagonist and/or a phosphodiesterase-5
inhibitor in subjects with pulmonary arterial hypertension, 2007-2010, Co-Investigator
20. An open label, long-term, safety and tolerability extension study using the pediatric
formulation of bosentan in the treatment of children with idiopathic or familial pulmonary
arterial hypertension who completed FUTURE 1: FUTURE 2, 2007-2012, Co-Investigator
21. TOPP Registry: tracking outcomes and practice in pediatric pulmonary hypertension,
Co-Investigator, 2007-present
22. QUERI Registry: pulmonary arterial hypertension quality enhancement research
initiative, Co-Investigator, 2006-2010
23. Congenital heart disease cardiac catheterization data consortium, Co-Investigator
24. REVEAL Registry: Registry to evaluate early and long-term PAH disease
management, Co-Investigator , 2006-2013
25. PEACH: Prospective evaluation of adolescents and children with pulmonary arterial
hypertension, PI, 2005-present
26. A Phase 2, Randomized, Double-blind, Placebo-controlled, Multicenter, Dose-ranging
Study of Cicletanine in Subjects with Pulmonary Arterial Hypertension, Co-Investigator,
2010-2012
27. A randomized, open label study comparing safety and efficacy parameters for a high
and a low dose of ambrisentan (adjusted for body weight) for the treatment of pulmonary
arterial hypertension in paediatric patients aged 8 years up to 18 years. Glaxo Smith
Kline, Co-Investigator, Steering Committee, 2010-present
28. An open label, prospective multicenter study to assess pharmacokinetics, tolerability
and safety of the pediatric formulation of bosentan twice versus three times a day in
children with pulmonary arterial hypertension, Future-3, Actelion, Co-Investigator,
Steering Committee, 2010-2013
29. PROSPECT Registry: Registry to Prospectively Describe Use of Epoprostenol For
Injection (“RTS Epoprostenol”) in Patients with Pulmonary Arterial Hypertension, CoInvestigator, 2010-2013
30. ASPIRE Study: “A Postmarketing Observational Study to Assess Respiratory Tract
Adverse Events in Pulmonary Arterial Hypertension (PAH) Patients Treated with Tyvaso
(treprostinil) Inhalation Solution” Co-Investigator, 2010-present
31. Protocol H6D-MC-LVIG: A Multiple Ascending Dose Study of Tadalafil to
Assess the Pharmacokinetics and Safety in a Pediatric Population with
Pulmonary Arterial Hypertension. Lilly, Data Safety Monitoring Board, 2011present
32. Protocol Protocol H6D-MC-LVHV. A Double-Blind Efficacy and Safety Study of the
Phosphodiesterase Type 5 Inhibitor Tadalafil in Pediatric Patients with Pulmonary Arterial
Hypertension. Steering Committee, 2011-present
33. A 24 week double-blind, placebo-controlled, randomized, multicenter clinical
trial to determine efficacy, safety and tolerability of QTI571 (imatinib) in the
treatment of children and adolescents, aged 9 months to < 18 years of age with
pulmonary arterial hypertension (PAH) who remain symptomatic on maximal
available PAH therapy. Novartis, Steering Committee, 2011-2013
34. A Phase 2, Placebo Controlled, Double-Blind, Randomized, Clinical Study to
Determine Safety, Tolerability and Efficacy of Pulsed, Inhaled Nitric Oxide (iNO)
Versus Placebo as Add-On Therapy in Symptomatic Subjects With Pulmonary
Arterial Hypertension, 2012-present
40
35. A multicenter, open-label, 24-week, uncontrolled study to evaluate the safety,
tolerability , and pharmacokinetics of oral treprostinil extended release tablets
following transition from Remodulin or inhaled prostacyclin therapy or as add-on
to current PAH therapy in prostacyclin-naïve pediatric patients aged 7 to 17
years with pulmonary arterial hypertension, United Therapeutics, Steering
Committee, 2014-present
Invited Regional / National Presentations / International Presentations
1. Diagnosis and Management of Aortic Stenosis
Eliza Fernie Pediatric/Neonatal Critical Care Symposium, Denver, CO, 1993
2. Moderator: Pulmonary Hypertension and Right Heart Failure
The Failing Heart. The Given Biomedical Institute, Aspen, CO, 1994
3. Endothelin in the Perinatal Period
Rocky Mountain Center for the Biology of Development, Breckenridge, CO, 1994
4. The Role of the Endothelium in Pulmonary Hypertension
Frontiers of Cardiology, Winter Park, CO, 1995
5. The Nitric Oxide-cGMP System in Pulmonary Hypertension
Frontiers of Cardiology, Winter Park, CO, 1996
6. Intravascular ultrasound in pediatric pulmonary hypertension. Team Approach to
Pediatric Cardiac Disease, Vail, CO, 1997
7. Nitric Oxide in Primary Pulmonary Hypertension
Pulmonary Hypertension Association Annual Meeting, Dallas, Texas, 1998
8. Role of Endothelin in Perinatal Pulmonary Vasoregulation. American Heart
Association. Scientific Conference on Control Mechanisms in the Fetal and Neonatal
Pulmonary Circulations, Sedalia, Colorado, 1998
9. Molecular Aspects of Pulmonary Hypertension
Frontiers in Cardiology, Kelsey-Seybold Foundation, Winter Park, CO, 1999
10. Hypoplastic Left Heart Syndrome
Eliza Fernie Pediatric/Neonatal Critical Care Symposium, Denver, CO, 1999
11. Role of the Endothelin B Receptor in Regulation of Pulmonary Vascular Tone
Department of Physiology, University of Wisconsin, Madison, WI, 1999
12. State of the Art: Management of severe pulmonary hypertension. American College
of Cardiology. Anaheim, CA, 2000
13. Journeys in Pediatric Pulmonary Hypertension
Pulmonary Hypertension Association Annual Meeting, Chicago, IL, 2000
14. Treatment of Severe Pulmonary Hypertension in Congenital Heart Disease
Department of Pediatrics, University of Texas Southwestern, Dallas, TX, 2000
15. Childhood Pulmonary Hypertension: Novel Therapies
United Kingdom Pulmonary Hypertension Association
Derby, England, 2001
16. Advances in medical management of severe pulmonary hypertension in children
Children’s Hospital of Philadelphia, Philadelphia, PA, 2002
17. Bosentan / Tracleer in Pulmonary Hypertension
Fifth International Pulmonary Hypertension Conference, Irvine, CA, 2002
18. Pulmonary Hypertension and Congenital Heart Disease
Fifth International Pulmonary Hypertension Conference, Irvine, CA, 2002
19. Inhaled Nitric Oxide in Pulmonary Hypertension
Fifth International Pulmonary Hypertension Conference, Irvine, CA, 2002
20. Ask the Parents / Ask the Kids
41
Fifth International Pulmonary Hypertension Conference, Irvine, CA, 2002
21. Flolan Treatment of Children and Patients with Congenital Heart Disease
Advisory Panel on Flolan, Chicago, IL, 2002
22. Advances in Treatment of Pediatric Pulmonary Hypertension
Canadian Pediatric Cardiology Society, Edmonton, Alberta, Canada, 2002
23. Diagnosis and Novel Treatment in Pediatric Pulmonary Hypertension
Jackson Memorial Hospital, Miami, Florida, 2003
24. Novel Treatments for Pediatric Pulmonary Hypertension
Team Approach to Pediatric Cardiac Disease
Sponsored by University of Oregon Health Sciences University, Vail, Colorado, 2003
25. A New Era in the Treatment of Pediatric Pulmonary Hypertension
Texas Children’s Hospital, Houston, Texas, 2003
26. Novel roles of the endothelin B receptor. American Thoracic Society
Special topics in pulmonary physiology: the next generation. Seattle, WA, 2003
27. Advances in treatment of pediatric pulmonary hypertension
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada, 2003
28. Diagnosis and Management of Severe Pediatric Pulmonary Hypertension
Society of Critical Care Medicine, 33rd Critical Care Congress, Orlando, FL, 2004
29. Bosentan / Tracleer in Pulmonary Hypertension
Sixth International Pulmonary Hypertension Conference, Miami, FL, 2004
30. Pulmonary Hypertension and Congenital Heart Disease
Sixth International Pulmonary Hypertension Conference, Miami, FL, 2004
31. Inhaled Nitric Oxide in Pulmonary Hypertension
Sixth International Pulmonary Hypertension Conference, Miami, FL, 2004
32. Ask the Parents / Ask the Kids
Sixth International Pulmonary Hypertension Conference, Miami, FL, 2004
33. The Latest in PH Therapies for Children
Sixth International Pulmonary Hypertension Conference, Miami, FL, 2004
34. Clinical Experience and Future Perspectives on the Use of Bosentan in Pulmonary
Arterial Hypertension Related to Congenital Heart Disease
Tracleer International Scientific Advisory Board Meeting, Lucerne, Switzerland, 2004
35. Genetics of Pulmonary Artery Hypertension
American Academy of Pediatrics, San Francisco, CA, 2004
36. Current and Emerging Therapies for Primary and Secondary Pulmonary Hypertension
in Children. American College of Chest Physicians, Seattle, WA, 2004
37. How to Evaluate and Manage Pediatric Patients with Pulmonary Hypertension
American Heart Association, New Orleans, LA, 2004
38. Advances in medical management of pediatric pulmonary hypertension
Southeastern Pediatric Cardiology Society, Nashville, TN, 2005
39. New pharmacology in the congenital armamentarium: Pulmonary Vascular Disease.
American College of Cardiology, Atlanta, GA, 2006
40. Advances in medical management of pediatric pulmonary hypertension
Western Society of Pediatric Cardiology, Newport Beach, CA, 2006
41. Pharmacotherapeutic options for pulmonary arterial hypertension in children.
American College of Chest Physicians, Salt Lake City, UT, 2006
42. Advances in medical management of severe pediatric pulmonary hypertension
University of Oklahoma, Oklahoma City, OK, 2007
43. Moderator, Can we fix fixed secondary pulmonary hypertension, American College of
Cardiology, Chicago, IL, March 2008
42
44. The evaluation and management of the patient with secondary pulmonary
hypertension, American College of Cardiology, Chicago, IL, March 2008
45. A new era in the medical management of the child with severe pulmonary
hypertension, Children’s Healthcare of Atlanta, April 2008
46. Medical treatment and lung transplantation in children with pulmonary hypertension
Eighth International Pulmonary Hypertension Conference, Houston, Texas, May 2008
47. Pulmonary hypertension: issues in adolescents and young women
Eighth International Pulmonary Hypertension Conference, Houston, Texas, May 2008
48. Advances in treatment of pediatric pulmonary hypertension. Nationwide Columbus
Children’s Hospital, October 2008
49. Proteomic evaluation of pediatric pulmonary hypertension. Nationwide Columbus
Children’s Hospital, October 2008
50. Prostanoids in the management of acute pulmonary hypertension. Pediatric Cardiac
Intensive care Society meeting, Miami, FL, December 2008
51. Preoperative testing: what do we make of vasodilator testing? 2 nd International
Neonatal and Childhood Pulmonary Vascular Disease, San Francisco, CA, March 2009
52. Update on management of severe pediatric pulmonary hypertension, 12 International
Vail conference on pediatric cardiac disease, Vail, CO, March 2009
53. Management of the acutely decompensated patient with chronic pulmonary
hypertension, 1st European Conference on Pediatric and Neonatal Cardiac Intensive
Care, Montreux, Switzerland, May 2009
54. A new era in the medical management of severe pediatric pulmonary arterial
hypertension. The 45th Annual Meeting of Japanese Society of Pediatric Cardiology and
Cardiac Surgery, Kobe, Japan, July 2009
55. Vasoreactivity testing in determining operability in congenital heart disease. The 45th
Annual Meeting of Japanese Society of Pediatric Cardiology and Cardiac Surgery, Kobe,
Japan, July 2009
56. A new era in the medical management of severe pediatric pulmonary arterial
hypertension. Evolving Concepts in the Management of Complex Congenital Heart
Disease II, San Diego, CA 2010
57. A new era in the medical management of severe pediatric pulmonary arterial
hypertension. Korean Pulmonary Hypertension Association, Seoul, Korea, 2010
58. Inhaled prostanoids in pediatric pulmonary arterial hypertension. Korean Pulmonary
Hypertension Association, Seoul, Korea, 2010
59. A new era in the medical management of severe pediatric pulmonary arterial
hypertension. Seoul National University Hospital, Seoul, Korea, 2010
60. Improving delivery of care through collaboration between administrators and
healthcare providers: Business meets cardiology: metrics and scorecards. Update on
Pediatric Cardiovascular Disease, Children’s Hospital of Philadelphia, Orlando, Florida,
February 2010.
61. Basic science and translational research: Neointimal lesions in the pulmonary arteries
of endothelin – B receptor deficient rats: a model for severe pulmonary hypertension.
Update on Pediatric Cardiovascular Disease, Children’s Hospital of Philadelphia,
Orlando, Florida, February 2010.
62. Challenges and solutions in moving patients and caregivers: Moving to an entirely
new hospital. Update on Pediatric Cardiovascular Disease, Children’s Hospital of
Philadelphia, Orlando, Florida, February 2010.
63. Developing evidence-based guidelines and protocols for the diagnosis and
management of pulmonary hypertension in children: How I work up a patient with
43
suspected pulmonary hypertension. Update on Pediatric Cardiovascular Disease,
Children’s Hospital of Philadelphia, Orlando, Florida, February 2010.
64. Developing evidence-based guidelines and protocols for the diagnosis and
management of pulmonary hypertension in children: How I minimize complications
following catheterization or non-cardiac surgery in patients with pulmonary hypertension.
Update on Pediatric Cardiovascular Disease, Children’s Hospital of Philadelphia,
Orlando, Florida, February 2010.
65. Cardiac catheterization is unnecessary in the evaluation of pulmonary hypertension:
CON. 3rd International Conference on Neonatal and Childhood Pulmonary Hypertension.
Banff, Canada, 2010
66. Cardiac catheterization: indications, hemodynamic evaluation and pitfalls. 3 rd
International Conference on Neonatal and Childhood Pulmonary Hypertension. Banff,
Canada, 2010
67. New medications in pediatric pulmonary hypertension
Ninth International Pulmonary Hypertension Conference, Garden Grove, CA, 2010
68. Ask the Parents / Ask the Kids
Ninth International Pulmonary Hypertension Conference, Garden Grove, CA, 2010
69. New medications in pediatric pulmonary hypertension
Joe DiMaggio Children’s Hospital, Hollywood, FL, 2010
70. Cardiac catheterization is unnecessary in the evaluation of pulmonary hypertension:
CON. Southeastern Pediatric Cardiology Meeting, Charlotte, NC, 2010
71. New medications in pediatric pulmonary hypertension
Southeastern Pediatric Cardiology Meeting, Charlotte, NC, 2010
72. Pediatric baseline data in the REVEAL registry
REVEAL registry yearly meeting, Boston, MA, 2010
73. Chronic Postoperative Pulmonary Hypertension: Pulmonary Arterial Hypertension in
Congenital Heart Disease, Vienna, Austria, 2011
74. An update on medical management for severe pulmonary hypertension.
13 International Vail conference on pediatric cardiac disease, Vail, CO, March 2011
75. Optimizing the pulmonary vasculature: From RDS to ARDS. Society of Pediatric
Research. State of the Art Plenary Session. Denver, CO. May 2011
76. High altitude pulmonary hypertension in children. High Altitude Summit. Keystone,
Colorado, October, 2011
77. Discovery proteomics in pediatric pulmonary hypertension. Syzygy: Congenital
Cardiology Group, California, February, 2012
78. Humanitarian Medicine in Nicaragua. Syzygy: Congenital Cardiology Group,
California, February, 2012
79. Survival and insights from the U.S. Pediatric Pulmonary Hypertension Reveal
Registry. Update on Pediatric Cardiovascular Disease, Children’s Hospital of
Philadelphia, Orlando, Florida, February, 2012.
80. The role of non-endothelial cells in pediatric pulmonary hypertension. Update on
Pediatric Cardiovascular Disease, Children’s Hospital of Philadelphia, Orlando, Florida,
February, 2012.
81. How should nitric oxide be used in the neonatal CHD patient in 2012. Update on
Pediatric Cardiovascular Disease, Children’s Hospital of Philadelphia, Orlando, Florida,
February, 2012.
82. Inhaled therapy for pediatric pulmonary hypertension. 4th International Conference on
Neonatal and Childhood Pulmonary Hypertension. San Francisco, California, 2012
44
83. Future expectations in pediatric pulmonary hypertension, European Society of
Cardiology, Pulmonary Hypertension: Future Expectations, Nice, France, October, 2012
84. The pediatric sildenafil trial and the FDA decisions, European Society of Cardiology,
Pulmonary Hypertension: Future Expectations, Nice, France, October, 2012
85. Diagnosis and management of portopulmonary hypertension in children. Studies of
Pediatric Liver Transplantation annual meeting, Denver, Colorado, October, 12012
86. Moderator. Hot Topics in Pediatric Pulmonary Hypertension. American Heart
Association Scientific Sessions, Los Angeles, CA, November, 2012
87. Chairman, Pediatric Task Force, World Symposium of Pulmonary Hypertension, Nice,
France, February 2013
88. Managing acute inhaled therapies in the critical care setting. 2013 PH Professional
Network Symposium. Arlington, VA, September, 2013
89. Pharmacological management of pediatric PAH. 2013 PH Professional Network
Symposium. Arlington, VA, September, 2013
90. Biomarkers in pediatric PAH. 1st European Conference on Neonatal and Pediatric
Pulmonary Vascular Disease. Groningen, Netherlands, October, 2013
91. Update on the World Symposium of Pulmonary Hypertension. 1 st European
Conference on Neonatal and Pediatric Pulmonary Vascular Disease. Groningen,
Netherlands, October, 2013
92. Development of a pediatric pulmonary hypertension program. Pulmonary Vascular
Research Institute, Giessen, Germany, January, 2014
93. The FDA Sildenafil Warning for Pediatric Pulmonary Hypertension, FDA, Washington,
DC, January, 2014
94. The Registry to Evaluate Early and Long Term PAH Disease Management: Pediatric
Cohort. 6th International Conference on Neonatal and Childhood Pulmonary
Hypertension. San Francisco, California, March 2014
95. The FDA and the sildenafil decision. Joint Council on Congenital Heart Disease.
Washington, DC, September 2014
96. Pulmonary Hypertension: Intravenous, Subcutaneous, Inhaled, or Oral – What to
Choose and Why. 10th International Pediatric Cardiac Intensive Care Society, Miami, FL,
December 2014
Grand Rounds
1. Diagnosis and Management of Primary Pulmonary Hypertension
Department of Pediatrics Grand Rounds
University of Wisconsin, Madison, WI, 1999
2. The Patrick Niland Lecture in Pediatric Cardiology
Department of Pediatrics Grand Rounds
University of Michigan, Ann Arbor, MI, 2000
3. Diagnosis and Novel Treatment in Pediatric Pulmonary Hypertension
Miami Children’s Hospital
Department of Pediatrics Grand Rounds
Miami, Florida, 2003
4. Novel Treatments in Pediatric Pulmonary Hypertension
Joe DiMaggio Children’s Hospital
Department of Pediatrics Grand Rounds
Miami, Florida , 2003
5. A New Era in the Treatment of Pediatric Pulmonary Hypertension
Department of Pediatrics Grand Rounds
45
Children’s Hospital of Quebec
Teleconference to Saint Justine Children’s Hospital / Montreal Children’s Hospital
Quebec City, Quebec, Canada, 2003
6. The Casden Lecture in Pediatric Cardiology
University of Oregon Health Sciences University
Department of Pediatrics Grand Rounds
Portland, OR, 2003
7. Pediatric Pulmonary Hypertension: An Update
Department of Pediatrics Grand Rounds
Wake Forest University School of Medicine
Greensborough, NC, 2003
8. A New Era in the Treatment of Pediatric Pulmonary Hypertension
Department of Pediatrics Grand Rounds
University of Iowa
Iowa City, IA, 2004
9. The Rae Lecture in Pediatric Cardiology
Department of Pediatrics Grand Rounds
Indiana University School of Medicine
Indianapolis, IN, April 2006
10. University of Minnesota
Department of Pediatrics Grand Rounds
Novel therapy in Pediatric Pulmonary Hypertension
Minneapolis, MN, August 2006
11. The Weinstein Lecture in Pediatric Cardiology
Department of Pediatrics Grand Rounds
Johns Hopkins University
Baltimore, MD, October, 2006
12. The MacDonald Dick Lecture in Pediatric Cardiology
Department of Pediatrics Grand Rounds
Ann Arbor, MI, December 2006
13. Rainbow Children’s Hospital
Department of Pediatrics Grand Rounds
Cleveland, OH, April 19, 2007
14. Shands Children’s Hospital
Department of Pediatrics Grand Rounds
Gainesville, FL, September, 2007
15. Arkansas Children’s Hospital
Department of Pediatrics Grand Rounds
Little Rock, AR, October 2007
16. The Fashena Lecture in Pediatric Cardiology
University of Texas Southwestern
Department of Pediatrics Grand Rounds
March 5, 2008
17. Wayne State University
Department of Pediatrics Grand Rounds
April 22, 2011
18. Miami Children’s Hospital
Department of Pediatrics Grand Rounds
April 20, 2012
46
19. Cincinnati Children’s Hospital
Department of Pediatrics Grand Rounds
May 29, 2012
20. Duke Children’s Hospital
Department of Pediatrics Grand Rounds
May 1, 2013
21. LeBonheur Children's Hospital
Department of Pediatrics Grand Rounds
James Hunt Lecture
November 20, 2013
22. Lucille Packard Children's Hospital
Department of Pediatrics Grand Rounds
Dunlieve Lecture
April 20, 2014
23. Omaha Children's Hospital
Department of Pediatrics Grand Rounds
October 17, 2014