Suggested Electronic Appendix Titles and Figure Legends
Table S1. Crude death rates in dialysis patients, by age and race/ethnicity.
Table S2. Crude kidney transplantation rates in dialysis patients, by age and race/ethnicity.
Table S3. Hazard ratios (95% confidence intervals) for all-cause mortality using case-mix* and fully-adjusted† Cox regression
models within 7 incremental age categories.
Table S4. Subhazard ratios (95% confidence intervals) for all-cause mortality using case-mix* and fully-adjusted† competing risk
regression models within 7 incremental age categories.
Table S5. Hazard ratios (95% confidence intervals) for kidney transplantation (all donor types) using case-mix* and fully-adjusted†
Cox regression models within 6 incremental age categories.
Table S6. Hazard ratios (95% confidence intervals) for deceased donor kidney transplantation using case-mix* and fully-adjusted†
Cox regression models within 6 incremental age categories.
Table S7. Hazard ratios (95% confidence intervals) for living donor kidney transplantation (related, unrelated, and unknown living
donor) using case-mix* and fully-adjusted† Cox regression models within 6 incremental age categories.‡
Table S8. Hazard ratios (95% confidence intervals) for living related donor kidney transplantation using case-mix* and fullyadjusted† Cox regression models within 6 incremental age categories.‡
Table S9. Hazard ratios (95% confidence intervals) for living unrelated donor kidney transplantation using case-mix* and fullyadjusted† Cox regression models within 6 incremental age categories.‡
Table S10. Baseline demographic, clinical and biochemical characteristics of dialysis patients, according to living or deceased status.
Figure S1. Algorithm of study cohort creation.
Figure S2. All-cause mortality hazard ratios within 7 age categories using case-mix (A) and fully-adjusted (B) Cox regression models
comparing 20,481 Hispanic (reference group) and 45,718 African-American dialysis patients. Error bars represent 95% confidence
intervals.
* Number of patients per age category: 18-30 years (n=4356), >30-40 years (n=9464), >40-50 years (n=17,670), >50-60 years (n=26,792), >60-70 years
(30,383), >70-80 years (28,446), >80 years (13,798).
Figure S3. Kidney transplantation (all types) hazard ratios within 6 age categories using case-mix (A) and fully-adjusted (B) Cox
regression models comparing 20,481 Hispanic (reference group) and 45,718 African-American dialysis patients. The age category
>80 years was not included due to unstable estimates resulting from a paucity of events.
*Age category >80 not included due to unstable estimates resulting from paucity of events
†Number of patients per age category: 18-30 years (n=4356), >30-40 years (n=9464), >40-50 years (n=17,670), >50-60 years (n=26,792), >60-70 years (30,383),
>70-80 years (28,446).
Table S1. Crude death rates in dialysis patients, by age and race/ethnicity
Age
categories
(years)
Non-Hispanic White
Death
Crude
Total
% (n)
mortality
rate
18 to 30
17.6
1520
18.4 (280)
[15.7-19.8]
1761
>30 to 40
26.6
3331
27.7 (923)
[24.9-28.3]
4430
>40 to 50
38.3
6546
38.8 (2540)
[36.8-39.8]
8135
>50 to 60
51.9
11,026
49.9 (5504)
[50.5-53.2]
11,065
>60 to 70
69.5
14,856
62.4 (9265)
[68.1-71.0]
10,418
>70 to 80
90.4
17,468
74.1 (12949)
[88.8-91.9]
7257
>80
121.6
9963
82.8 (8247)
[119.0-124.2]
2652
Total
70.0
64,710
61.4 (39,708)
[69.3-70.7]
45,718
Crude mortality rate (per 100,000 person days) [95% confidence interval]
Total
African-American
Death
% (n)
21.9 (385)
28.8 (1274)
38.2 (3111)
46.2 (5113)
58.1 (6048)
70.9 (5144)
82.5 (2187)
50.9 (23,262)
Crude
mortality
rate
17.2
[15.6-19.0]
21.7
[20.5-22.9]
29.6
[28.5-30.6]
38.8
[37.8-39.9]
52.5
[51.2-53.9]
73.2
[71.3-75.3]
114.0
[109.3-118.9]
44.5
[43.9-45.1]
Total
Hispanic
Death
% (n)
1075
9.4 (101)
1703
17.8 (303)
2989
31.3 (934)
4701
43.5 (2047)
5109
56.8 (2900)
3721
71.8 (2672)
1183
81.5 (964)
20,481
48.4 (9921)
Crude
mortality
rate
7.3
[6.0-8.9]
13.0
[11.6-14.6]
23.8
[22.3-25.3]
34.6
[33.1-36.1]
50.4
[48.6-52.3]
73.2
[70.5-76.1]
109.5
[102.8-116.7]
41.6
[40.8-42.4]
Table S2. Crude kidney transplantation rates in dialysis patients, by age and race/ethnicity
Age
categories
(years)
Non-Hispanic White
African-American
Total
Transplant
Crude
Total
Transplant
Crude
% (n)
transplantation
% (n)
transplantation
rate
rate
18 to 30
31.5
19.4
1520
32.9 (500)
[28.9-34.4]
1761
24.6 (434)
[17.7-21.3]
>30 to 40
25.8
12.7
3331
26.9 (896)
[24.1-27.5]
4430
16.8 (744)
[11.8-13.6]
>40 to 50
21.7
8.9
6546
22.0 (1437)
[20.6-22.8]
8135
11.5 (933)
[8.3-9.5]
>50 to 60
17.5
8.6
11,026
16.8 (1856)
[16.7-18.3]
11,065
10.2 (1129)
[8.1-9.1]
>60 to 70
10.9
5.2
14,856
9.8 (1457)
[10.4-11.5]
10,418
5.8 (600)
[4.8-5.6]
>70 to 80
2.6
1.1
17,468
2.2 (377)
[2.4-2.9]
7257
1.0 (75)
[0.9-1.3]
>80
0.2
0.1
9963
0.1 (12)
[0.1-0.3]
2652
0.03 (1)
[0.0-0.4]
Total
11.5
7.5
64,710
10.1 (6535)
[11.2-11.8]
45,718
8.6 (3916)
[7.3-7.7]
Crude transplantation rate (per 100,000 person days) [95% confidence interval]
Total
Hispanic
Transplant
% (n)
1075
32.6 (350)
1703
25.6 (436)
2989
17.2 (514)
4701
11.8 (556)
5109
6.5 (333)
3721
1.0 (37)
1183
0 (0)
20,481
2226
Crude
transplantation
rate
25.3
[22.8-28.1]
18.7
[17.1-20.6]
13.1
[12.0-14.3]
9.4
[8.6-10.2]
5.8
[5.2-6.4]
1.0
[0.7-1.4]
0
[0]
9.3
[9.0-9.7]
Table S3. Hazard ratios (95% confidence intervals) for all-cause mortality using case-mix* and
fully-adjusted† Cox regression models within 7 incremental age categories.
Age group
(years)
N
African-American vs.
White
Hispanic vs.
White
African-American vs.
Hispanic
Case-mix
Fully
Case-mix
Fully
Case-mix
Fully
adjusted
adjusted
adjusted
adjusted
adjusted
adjusted
18 to 30
4356
0.97
1.00
0.44
0.52
2.63
2.50
[0.81-1.16]
[0.81-1.24]
[0.34-0.58]
[0.39-0.69]
[2.04-3.38]
[1.89-3.31]
p=0.8
p=0.9
p<0.001
p<0.001
p<0.001
p<0.001
>30 to 40
0.91
1.01
0.51
0.58
1.86
1.90
9464
[0.83-1.01]
[0.90-1.14]
[0.44-0.59]
[0.49-0.68]
[1.61-2.14] [1.62- 2.23]
p=0.07
p=0.8
p<0.001
p<0.001
p<0.001
p<0.001
>40 to 50
17,670
0.77
0.89
0.59
0.62
1.30
1.41
[0.73-0.82]
[0.83-0.96]
[0.54-0.64]
[0.57-0.69]
[1.19-1.41]
[1.29-1.55]
p<0.001
p=0.002
p<0.001
p<0.001
p<0.001
p<0.001
>50 to 60
26,792
0.72
0.86
0.60
0.66
1.22
1.36
[0.69-0.75] [0.82- 0.91] [0.56-0.63]
[0.61-0.70]
[1.15-1.30]
[1.27-1.45]
p<0.001
p<0.001
p<0.001
p<0.001
p<0.001
p<0.001
>60 to 70
30,383
0.73
0.85
0.68
0.77
1.09
1.14
[0.70-0.76]
[0.81-0.89]
[0.65-0.72]
[0.73-0.81]
[1.03-1.14]
[1.07-1.20]
p<0.001
p<0.001
p<0.001
p<0.001
p=0.001
p<0.001
>70 to 80
0.80
0.83
0.81
0.87
0.97
0.93
28,446
[0.77-0.83]
[0.80-0.87]
[0.77-0.84]
[0.83-0.92]
[0.92-1.02]
[0.88-0.99]
p<0.001
p<0.001
p<0.001
p<0.001
p=0.3
p=0.02
>80
13,798
0.90
0.87
0.89
0.87
1.00
0.99
[0.86-0.95]
[0.82-0.92]
[0.83-0.96]
[0.80-0.94]
[0.92-1.09] [0.90- 1.09]
p<0.001
p<0.001
p=0.002
p<0.001
p=0.9
p=0.8
Note: Analyses were performed in a total of 130,909 dialysis patients including 64,710 non-Hispanic Whites, 45,718
African-Americans and 20,481 Hispanics. Each model compares dialysis patients from 2 of the 3 racial/ethnic
groups.
*Case-mix analyses adjusted for age, sex, primary insurance, entry calendar quarter, body mass index, dialysis
modality, diabetes, active tobacco smoking, alcohol dependence, drug dependence, atherosclerotic heart disease,
hypertension, cardiac failure, peripheral vascular disease, cerebrovascular disease, chronic obstructive pulmonary
disease, malignancy, and non-ambulatory state.
†Fully-adjusted analyses adjusted for all the covariates in the case-mix adjusted model plus marital status, dialysis
vintage, residual renal function, single pool kt/v, serum phosphate, albumin, total iron binding capacity, calcium,
bicarbonate, creatinine, ferritin, hemoglobin, peripheral white blood cell count, lymphocyte percentage, and
normalized protein catabolic rate.
Table S4. Subhazard ratios (95% confidence intervals) for all-cause mortality using case-mix*
and fully-adjusted† competing risk regression models within 7 incremental age categories.
Age group
(years)
N
African-American vs.
White
Hispanic vs.
White
African-American vs.
Hispanic
Case-mix
Fully
Case-mix
Fully
Case-mix
Fully
adjusted
adjusted
adjusted
adjusted
adjusted
adjusted
18 to 30
4356
1.18
1.15
0.50
0.57
2.77
2.48
[0.99-1.40]
[0.94-1.40]
[0.39-0.66]
[0.43-0.75]
[2.16-3.56]
[1.91-3.22]
p=0.06
p=0.2
p<0.001
p<0.001
p<0.001
p<0.001
>30 to 40
1.11
1.23
0.59
0.69
1.99
1.98
9464
[1.01-1.21]
[1.10-1.36]
[0.51-0.68]
[0.59-0.80]
[1.74-2.27]
[1.72-2.28]
p=0.03
p<0.001
p<0.001
p<0.001
p<0.001
p<0.001
>40 to 50
17,670
0.92
1.05
0.67
0.72
1.37
1.45
[0.87-0.97]
[0.99-1.12]
[0.61-0.72]
[0.66-0.79]
[1.27-1.48]
[1.33-1.58]
p=0.003
p=0.1
p<0.001
p<0.001
p<0.001
p<0.001
>50 to 60
26,792
0.82
0.97
0.67
0.75
1.25
1.35
[0.79-0.85]
[0.93-1.02]
[0.63-0.71]
[0.70-0.80]
[1.18-1.32]
[1.27-1.44]
p<0.001
p=0.2
p<0.001
p<0.001
p<0.001
p<0.001
>60 to 70
30,383
0.80
0.92
0.74
0.84
1.09
1.12
[0.78-0.83]
[0.88-0.96]
[0.71-0.78]
[0.80-0.88]
[1.04-1.14]
[1.06-1.19]
p<0.001
p<0.001
p<0.001
p<0.001
p<0.001
p<0.001
>70 to 80
0.83
0.90
0.83
0.91
0.98
0.96
28,446
[0.81-0.86]
[0.86-0.94]
[0.80-0.87]
[0.87-0.96]
[0.93-1.03
[0.90-1.02]
p<0.001
p<0.001
p<0.001
p<0.001
p=0.4
p=0.2
>80
13,798
0.91
0.88
0.89
0.87
1.01
1.00
[0.87-0.96]
[0.81-0.94]
[0.83-0.96]
[0.79-0.95]
[0.94-1.10]
[0.91-1.10]
p=0.001
p<0.001
p=0.001
p=0.002
p=0.7
p>0.9
Note: Analyses were performed in a total of 130,909 dialysis patients including 64,710 non-Hispanic Whites, 45,718
African-Americans and 20,481 Hispanics. Each model compares dialysis patients from 2 of the 3 racial/ethnic
groups.
*Case-mix analyses adjusted for age, sex, primary insurance, entry calendar quarter, body mass index, dialysis
modality, diabetes, active tobacco smoking, alcohol dependence, drug dependence, atherosclerotic heart disease,
hypertension, cardiac failure, peripheral vascular disease, cerebrovascular disease, chronic obstructive pulmonary
disease, malignancy, and non-ambulatory state.
†Fully-adjusted analyses adjusted for all the covariates in the case-mix adjusted model plus marital status, dialysis
vintage, residual renal function, single pool kt/v, serum phosphate, albumin, total iron binding capacity, calcium,
bicarbonate, creatinine, ferritin, hemoglobin, peripheral white blood cell count, lymphocyte percentage, and
normalized protein catabolic rate.
Table S5. Hazard ratios (95% confidence intervals) for kidney transplantation (all donor types)
using case-mix* and fully-adjusted† Cox regression models within 6 incremental age
categories.‡
Age
groups
(years)
N
African-American vs.
White
Hispanic vs.
White
African-American vs.
Hispanic
Case-mix
adjusted
Fully
adjusted
Case-mix
adjusted
Fully
adjusted
Case-mix
adjusted
Fully
adjusted
18 to 30
4356
0.62
[0.54-0.72]
p<0.001
0.63
[0.53-0.76]
p <0.001
0.84
[0.71-0.98]
p=0.03
0.80
[0.67-0.96]
p=0.02
0.72
[0.61-0.85]
p<0.001
0.73
[0.60-0.88]
p=0.001
>30 to 40
9464
0.52
[0.47-0.58]
p<0.001
0.53
[0.46-0.61]
p<0.001
0.78
[0.68-0.89]
p<0.001
0.72
[0.62-0.83]
p<0.001
0.64
[0.56- 0.73]
p<0.001
0.70
[0.60-0.82]
p<0.001
>40 to 50
17,670
0.44
[0.40-0.48]
p<0.001
0.41
[0.37-0.46]
p<0.001
0.65
[0.58-0.73]
p<0.001
0.64
[0.56-0.72]
p<0.001
0.67
[0.59-0.76]
p<0.001
0.62
[0.54-0.72]
p<0.001
>50 to 60
26,792
0.51
[0.47-0.55]
p<0.001
0.47
[0.42-0.52]
p<0.001
0.64
[0.57-0.71]
p<0.001
0.61
[0.54-0.69]
p<0.001
0.81
[0.73-0.91]
p<0.001
0.71
[0.62-0.82]
p<0.001
>60 to 70
30,383
0.51
[0.46-0.57]
p<0.001
0.41
[0.35-0.47]
p<0.001
0.63
[0.55-0.72]
p<0.001
0.62
[0.53-0.72]
p<0.001
0.85
[0.73-0.99]
p=0.03
0.67
[0.56-0.81]
p<0.001
>70 to 80
28,446
0.43
[0.32-0.56]
p<0.001
0.34
[0.24-0.49]
p<0.001
0.37
[0.25-0.56]
p<0.001
0.32
[0.20-0.51]
p<0.001
1.31
[0.83-2.08]
p=0.2
1.00
[0.55-1.82]
p=0.9
Note: Analyses were performed in a total of 130,909 dialysis patients including 64,710 non-Hispanic Whites, 45,718
African-Americans and 20,481 Hispanics. Each model compares dialysis patients from 2 of the 3 racial/ethnic
groups.
*Case-mix analyses adjusted for age, sex, primary insurance, entry calendar quarter, body mass index, dialysis
modality, diabetes, active tobacco smoking, alcohol dependence, drug dependence, atherosclerotic heart disease,
hypertension, cardiac failure, peripheral vascular disease, cerebrovascular disease, chronic obstructive pulmonary
disease, malignancy, and non-ambulatory state.
†Fully-adjusted analyses adjusted for all the covariates in the case-mix adjusted model plus marital status, dialysis
vintage, residual renal function, single pool kt/v, serum phosphate, albumin, total iron binding capacity, calcium,
bicarbonate, creatinine, ferritin, hemoglobin, peripheral white blood cell count, lymphocyte percentage, and
normalized protein catabolic rate.
‡Age category >80 not included due to unstable estimates resulting from paucity of events
Table S6. Hazard ratios (95% confidence intervals) for deceased donor kidney transplantation
using case-mix* and fully-adjusted† Cox regression models within 6 incremental age
categories.‡
Age groups
(years)
N
African-American vs.
White
Hispanic vs.
White
African-American vs.
Hispanic
Case-mix
adjusted
Fully
adjusted
Case-mix
adjusted
Fully
adjusted
Case-mix
adjusted
Fully
adjusted
18 to 30
4356
0.99
[0.80-1.22]
0.9
0.99
[0.77-1.27]
0.9
1.02
[0.79-1.32]
0.9
0.91
[0.69-1.20]
0.5
0.98
[0.78-1.24]
0.9
0.95
[0.73-1.23]
0.7
>30 to 40
9464
0.74
[0.64-0.85]
<0.001
0.67
[0.57-0.79]
<0.001
0.82
[0.68-0.99]
0.04
0.72
[0.59-0.88]
0.001
0.86
[0.72-1.02]
0.09
0.80
[0.65-0.97]
0.03
>40 to 50
17,670
0.57
[0.51-0.64]
<0.001
0.51
[0.44-0.58]
<0.001
0.80
[0.69-0.92]
0.002
0.73
[0.63-0.85]
<0.001
0.74
[0.64-0.85]
<0.001
0.69
[0.59-0.80]
<0.001
>50 to 60
26,792
0.61
[0.56-0.67]
<0.001
0.52
[0.46-0.58]
<0.001
0.70
[0.61-0.79]
<0.001
0.62
[0.55-0.71]
<0.001
0.93
[0.81-1.06]
0.3
0.82
[0.71-0.95]
0.007
>60 to 70
30,383
0.56
[0.50-0.63]
<0.001
0.51
[0.45-0.59]
<0.001
0.68
[0.59-0.80]
<0.001
0.63
[0.53-0.74]
<0.001
0.86
[0.73-1.02]
0.08
0.80
[0.66-0.96]
0.02
>70 to 80
28,446
0.50
[0.37-0.67]
<0.001
0.40
[0.28-0.56]
<0.001
0.45
[0.29-0.68]
<0.001
0.40
[0.26-0.61]
<0.001
1.21
[0.75-1.96]
0.4
0.85
[0.50-1.47]
0.6
Note: Analyses were performed in a total of 130,909 dialysis patients including 64,710 non-Hispanic Whites, 45,718
African-Americans and 20,481 Hispanics. Each model compares dialysis patients from 2 of the 3 racial/ethnic
groups.
*Case-mix analyses adjusted for age, sex, primary insurance, entry calendar quarter, body mass index, dialysis
modality, diabetes, active tobacco smoking, alcohol dependence, drug dependence, atherosclerotic heart disease,
hypertension, cardiac failure, peripheral vascular disease, cerebrovascular disease, chronic obstructive pulmonary
disease, malignancy, and non-ambulatory state.
†Fully-adjusted analyses adjusted for all the covariates in the case-mix adjusted model plus marital status, dialysis
vintage, residual renal function, single pool kt/v, serum phosphate, albumin, total iron binding capacity, calcium,
bicarbonate, creatinine, ferritin, hemoglobin, peripheral white blood cell count, lymphocyte percentage, and
normalized protein catabolic rate.
‡Age category >80 not included due to unstable estimates resulting from paucity of events
Table S7. Hazard ratios (95% confidence intervals) for living donor kidney transplantation
(related, unrelated, and unknown living donor) using case-mix* and fully-adjusted† Cox
regression models within 6 incremental age categories.‡
Age groups
(years)
N
African-American vs.
White
Hispanic vs.
White
African-American vs.
Hispanic
Case-mix
adjusted
Fully
adjusted
Case-mix
adjusted
Fully
adjusted
Case-mix
adjusted
Fully
adjusted
18 to 30
4356
0.38
[0.31-0.48]
<0.001
0.41
[0.31-0.53]
<0.001
0.64
[0.51-0.81]
<0.001
0.64
[0.50-0.82]
<0.001
0.59
[0.45-0.77]
<0.001
0.67
[0.49-0.91]
0.01
>30 to 40
9464
0.37 [0.300.45]
<0.001
0.42
[0.33-0.53]
<0.001
0.63
[0.51-0.79]
<0.001
0.63
[0.50-0.80]
<0.001
0.58 [0.450.75]
<0.001
0.67
[0.50-0.89]
0.005
>40 to 50
17,670
0.27
[0.23-0.32]
<0.001
0.29
[0.24-0.35]
<0.001
0.47
[0.38-0.58]
<0.001
0.46
[0.37-0.58]
<0.001
0.61
[0.48-0.78]
<0.001
0.60
[0.46-0.79]
<0.001
>50 to 60
26,792
0.35
[0.29-0.40]
<0.001
0.39
[0.32-0.47]
<0.001
0.48
[0.39-0.60]
<0.001
0.47
[0.38-0.59]
<0.001
0.68
[0.53-0.88]
0.003
0.72
[0.55-0.95]
0.02
>60 to 70
30,383
0.31 [0.240.39]
<0.001
0.28
[0.21-0.36]
<0.001
0.43
[0.32-0.58]
<0.001
0.41
[0.31-0.56]
<0.001
0.78
[0.55-1.10]
0.2
0.68
[0.46-1.01]
0.05
>70 to 80
28,446
0.18
[0.08-0.40]
<0.001
0.25 [0.110.58]
0.001
0.27
[0.11-0.68]
0.005
0.26
[0.10-0.65]
0.004
0.63 [0.192.13]
0.5
1.15
[0.26-5.15]
0.9
Note: Analyses were performed in a total of 130,909 dialysis patients including 64,710 non-Hispanic Whites, 45,718
African-Americans and 20,481 Hispanics. Each model compares dialysis patients from 2 of the 3 racial/ethnic
groups.
*Case-mix analyses adjusted for age, sex, primary insurance, entry calendar quarter, body mass index, dialysis
modality, diabetes, active tobacco smoking, alcohol dependence, drug dependence, atherosclerotic heart disease,
hypertension, cardiac failure, peripheral vascular disease, cerebrovascular disease, chronic obstructive pulmonary
disease, malignancy, and non-ambulatory state.
†Fully-adjusted analyses adjusted for all the covariates in the case-mix adjusted model plus marital status, dialysis
vintage, residual renal function, single pool kt/v, serum phosphate, albumin, total iron binding capacity, calcium,
bicarbonate, creatinine, ferritin, hemoglobin, peripheral white blood cell count, lymphocyte percentage, and
normalized protein catabolic rate.
‡Age category >80 not included due to unstable estimates resulting from paucity of events
Table S8. Hazard ratios (95% confidence intervals) for living related donor kidney
transplantation using case-mix* and fully-adjusted† Cox regression models within 6 incremental
age categories.‡
Age groups
(years)
N
African-American vs.
White
Hispanic vs.
White
African-American vs.
Hispanic
Case-mix
adjusted
Fully
adjusted
Case-mix
adjusted
Fully
adjusted
Case-mix
adjusted
Fully
adjusted
18 to 30
4356
0.38 [0.290.50]
<0.001
0.42
[0.31-0.57]
<0.001
0.68
[0.53-0.88]
0.003
0.69
[0.52-0.90]
0.007
0.54
[0.40-0.73]
<0.001
0.62
[0.43-0.87]
0.007
>30 to 40
9464
0.41
[0.32-0.54]
<0.001
0.53
[0.40-0.72]
<0.001
0.75
[0.56-0.99]
0.04
0.81
[0.60-1.09]
0.2
0.52
[0.38-0.72]
<0.001
0.65
[0.46-0.94]
0.02
>40 to 50
17,670
0.31
[0.25-0.39]
<0.001
0.33
[0.25-0.43]
<0.001
0.62
[0.47-0.80]
<0.001
0.63
[0.47-0.83]
0.001
0.53
[0.39-0.72]
<0.001
0.49
[0.34-0.69]
<0.001
>50 to 60
26,792
0.41
[0.34-0.51]
<0.001
0.49
[0.38-0.63]
<0.001
0.68
[0.53-0.88]
0.004
0.68
[0.52-0.89]
0.004
0.60
[0.45-0.79]
<0.001
0.59
[0.43-0.80]
<0.001
>60 to 70
30,383
0.34
[0.26-0.46]
<0.001
0.30
[0.21-0.40]
<0.001
0.55
[0.40-0.77]
<0.001
0.50
[0.36-0.70]
<0.001
0.64
[0.43-0.95]
0.02
0.59
[0.38-0.92]
0.02
>70 to 80
28,446
0.18
[0.07-0.46]
<0.001
0.27
[0.10-0.71]
0.008
0.24
[0.07-0.76]
0.02
0.21
[0.07-0.70]
0.01
0.59
[0.11-3.17]
0.5
N/A‡
Note: Analyses were performed in a total of 130,909 dialysis patients including 64,710 non-Hispanic Whites, 45,718
African-Americans and 20,481 Hispanics. Each model compares dialysis patients from 2 of the 3 racial/ethnic
groups.
*Case-mix analyses adjusted for age, sex, primary insurance, entry calendar quarter, body mass index, dialysis
modality, diabetes, active tobacco smoking, alcohol dependence, drug dependence, atherosclerotic heart disease,
hypertension, cardiac failure, peripheral vascular disease, cerebrovascular disease, chronic obstructive pulmonary
disease, malignancy, and non-ambulatory state.
†Fully-adjusted analyses adjusted for all the covariates in the case-mix adjusted model plus marital status, dialysis
vintage, residual renal function, single pool kt/v, serum phosphate, albumin, total iron binding capacity, calcium,
bicarbonate, creatinine, ferritin, hemoglobin, peripheral white blood cell count, lymphocyte percentage, and
normalized protein catabolic rate.
‡Age category >80 for all race/ethnicity comparisons and age category >70-80for African-Americans vs. Hispanics
not included due to unstable estimates resulting from paucity of events
Table S9. Hazard ratios (95% confidence intervals) for living unrelated donor kidney
transplantation using case-mix* and fully-adjusted† Cox regression models within 6 incremental
age categories.‡
Age groups
(years)
N
African-American vs.
White
Hispanic vs.
White
African-American vs.
Hispanic
Case-mix
adjusted
Fully
adjusted
Case-mix
adjusted
Fully
adjusted
Case-mix
adjusted
Fully
adjusted
18 to 30
4356
0.39
[0.25-0.62]
<0.001
0.35
[0.20-0.60]
<0.001
0.52
[0.31-0.88]
0.01
0.49
[0.29-0.86]
0.01
0.82
[0.46-1.48]
0.5
0.91
[0.46-1.80]
0.8
>30 to 40
9464
0.32
[0.23-0.43]
<0.001
0.31
[0.21-0.44]
<0.001
0.48
[0.33-0.70]
<0.001
0.45
[0.30-0.67]
<0.001
0.68
[0.45-1.05]
0.08
0.68
[0.42-1.10]
0.1
>40 to 50
17,670
0.23
[0.17-0.30]
<0.001
0.24
[0.18-0.33]
<0.001
0.31
[0.21-0.45]
<0.001
0.29
[0.20-0.43]
<0.001
0.80
[0.52-1.23]
0.3
0.89
[0.55-1.42]
0.6
>50 to 60
26,792
0.25
[0.18-0.33]
<0.001
0.26
[0.18-0.36]
<0.001
0.20
[0.12-0.32]
<0.001
0.19
[0.11-0.32]
<0.001
1.13
[0.65-1.98]
0.7
1.39
[0.76-2.56]
0.3
>60 to 70
30,383
0.25
[0.16-0.37]
<0.001
0.25
[0.16-0.40]
<0.001
0.22
[0.11-0.42]
<0.001
0.23
[0.12-0.45]
<0.001
1.48
[0.70-3.15]
0.3
1.09
[0.46-2.56]
0.9
>70 to 80
28,446
0.18
[0.04-0.78]
0.02
0.22
[0.05-1.03]
0.06
0.37
[0.09-1.62]
0.2
0.36
[0.08-1.60]
0.2
0.45
[0.06-3.45]
0.4
0.45
[0.02-8.60]
0.6
Note: Analyses were performed in a total of 130,909 dialysis patients including 64,710 non-Hispanic Whites, 45,718
African-Americans and 20,481 Hispanics. Each model compares dialysis patients from 2 of the 3 racial/ethnic
groups.
*Case-mix analyses adjusted for age, sex, primary insurance, entry calendar quarter, body mass index, dialysis
modality, diabetes, active tobacco smoking, alcohol dependence, drug dependence, atherosclerotic heart disease,
hypertension, cardiac failure, peripheral vascular disease, cerebrovascular disease, chronic obstructive pulmonary
disease, malignancy, and non-ambulatory state.
†Fully-adjusted analyses adjusted for all the covariates in the case-mix adjusted model plus marital status, dialysis
vintage, residual renal function, single pool kt/v, serum phosphate, albumin, total iron binding capacity, calcium,
bicarbonate, creatinine, ferritin, hemoglobin, peripheral white blood cell count, lymphocyte percentage, and
normalized protein catabolic rate.
‡Age category >80 not included due to unstable estimates resulting from paucity of events
Table S10. Baseline demographic, clinical and biochemical characteristics of dialysis patients,
according to living or deceased status.
Age group (years)
All
Alive
Died
p-value
No. of patients
Age in years
Mean (SD)
Women (%)
Diabetes mellitus (%)
130,909
61±15
58,018
55±15
72,891
66±14
45
56
44
49
46
62
<0.001
<0.001
<0.001
13
31
35
21
14
32
33
21
12
30
36
22
<0.001
<0.001
<0.001
<0.001
93
7
92
8
94
6
<0.001
<0.001
69
5
10
16
62
6
9
23
74
5
11
10
<0.001
<0.001
<0.001
<0.001
Marital status (%)
Married
Divorced
Single
Widowed
49
8
28
15
50
8
33
9
48
8
23
21
<0.001
0.8
<0.001
<0.001
Comorbidities (%)
AHD
21
14
27
Hypertension
Cardiac failure
80
27
81
19
79
33
PVD
11
7
15
7
6
5
3
5
1
1
0.43±1.46
27.0±7.0
5
3
3
1
5
1
1
0.54±1.67
28.0±7.2
9
8
6
4
5
1
1
0.35±1.29
26.3±6.8
<0.001
<0.001
<0.001
<0.001
<0.001
<0.001
<0.001
<0.001
<0.001
<0.001
0.5
<0.001
<0.001
4
41
29
15
11
2
37
30
17
14
5
44
28
13
10
1.52±0.35
1.52±0.37
1.52±0.35
0.94±0.25
0.96±0.25
0.93±0.25
<0.001
<0.001
<0.001
<0.001
<0.001
0.5
<0.001
3.66±0.47
3.80±0.43
3.57±0.47
<0.001
Vintage (%)
<6 months
6 to <24 months
2 to <5 years
≥5 years
Dialysis modality (%)
Hemodialysis
Peritoneal dialysis
Primary insurance (%)
Medicare
Medicaid
Private insurance
Other
CVD
COPD
Malignancy
Non-ambulatory state
Active smoking
Alcohol use
Drug use
RRF (ml/min) Mean (SD)
BMI (kg/m2) Mean (SD)
BMI groups (%)
<18
18- 24.99
25- 29.99
30- 34.99
≥35
spKt/V Mean (SD)
nPCR (g/kg/day) Mean (SD)
Serum Levels Mean (SD)
Albumin (mg/dL)
Creatinine (mg/dL)
TIBC (mg/dL)
Bicarbonate (mg/dL)
Phosphorus (mg/dL)
Calcium (mg/dL)
iPTH (pg/mL)
Alk Phos (U/L)
Ferritin (ng/mL)
Hemoglobin (g/dL)
WBC (x103/µL)
Lymphocyte Percentage
8.0±3.4
211±47
8.8±3.7
220±45
7.5±3.0
204±48
22.6±3.1
5.5±1.5
9.2±0.7
351±368
119±89
496±481
22.6±3.1
5.7±1.5
9.3±0.7
385±399
111±77
429±406
22.6±3.1
5.5±1.5
9.2±0.7
331±348
125±96
543±523
12.0±1.4
12.2±1.4
11.9±1.4
7.5±2.6
21±8
7.2±2.2
22±8
7.7±2.8
19±8
<0.001
<0.001
0.1
<0.001
<0.001
<0.001
<0.001
<0.001
<0.001
<0.001
<0.001
Figure S1.
164,789 DaVita patients
13,900 patients <18 years old
were excluded
150,889 DaVita patients
16,617 patients not of white,
African-American, or
Hispanic race/ethnicity were
excluded
130,909 DaVita patients
64,710
White patients
45,718
African-American
patients
3,363 patients whose dialysis
vintage was <90 days were
excluded
20,481
Hispanic patients
Figure S2.
A.
B.
Figure S3.
A.
B.