02/17/16
CURRICULUM VITAE
PERSONAL DATA:
Name:
John Andrew Williams
Department of Molecular & Integrative Physiology
University of Michigan Medical School
7744 Medical Science II
Ann Arbor, MI 48109-0622
Tele: 734-647-2886; Fax: 734-936-8813
Email: jawillms@umich.edu
EDUCATION:
1955-1959
1959-1962
1962-1968
1962-1968
Ellensburg High School, Ellensburg, WA
Central Washington State, BA Premedicine
University of Washington School of Medicine, MD
(With highest honors)
University of Washington School of Medicine, PhD
Physiology and Biophysics
POSTDOCTORAL TRAINING:
1968-1969
University of Utah, Department of Pharmacology,
NIH Postdoctoral Fellow
1969-1971
National Institute of Arthritis and Metabolic Diseases,
Staff Associate, Clinical Endocrinology Branch
1971-1972
Helen Hay Whitney Foundation Fellow,
Department of Pharmacology University of Cambridge, UK
ACADEMIC APPOINTMENTS:
1973-1974
1974-1979
1979-1987
1981-1987
1975-1987
1978
1979-1987
1982
1983
11/1987-8/2008
198820082009-
Assistant Professor, Department of Physiology,
University of California, San Francisco
Associate Professor, Department of Physiology, UCSF
Professor, Department of Physiology, UCSF
Professor, Department of Medicine, UCSF
Vice-Chair, Department of Physiology, UCSF
Visiting Professor of Japan Society for Promotion of Science,
Hokkaido University (May-August)
Co-Director, Laboratory of Cell Biology, Department of Medicine,
Mount Zion Hospital, San Francisco, California
Visiting Scientist, Physiology Institute, University of Copenhagen
(June-August)
Acting Chair, Department of Physiology, University of California,
San Francisco (September-December)
Professor and Chair, Department of Molecular & Integrative Physiology,
University of Michigan, Ann Arbor
Professor of Internal Medicine, University of Michigan,
Professor of Molecular & Integrative Physiology, Univ of Michigan
Horace W. Davenport Collegiate Professor of Physiology, Univ of Michigan
1
John A. Williams
SCIENTIFIC ACTIVITIES:
Research Interests:
Gastrointestinal Physiology; Cell Physiology; Endocrinology
Study Sections:
1984-1987 NIH Gastroenterology and Clinical Nutrition Study Section,
1991-1995 NIDDK Special Grants Review Committee C for Digestive Disease
and Nutrition, Chair 1994-95
2003-2004 Veterans Administration Gastroenterology Review Panel
Member various NIH special study sections
Reviewer of Grant Proposals for: NIH
NSF
Veterans Administration
Canadian Medical Research Council
Swiss National Science Foundation
British Columbia Health Services
Wellcome Foundation
Australian Research Council
Pennsylvania Department of Health
Editorial Boards:
1985-1991 Editor, American Journal of Physiology, Gastrointestinal and Liver Physiology
Editorial Board (1982-1985, 1991- present)
1981-1983 Cell Calcium, Editorial Board
1984-1988 Diabetes Research and Clinical Practice, Editorial Board
1985-1997 The Pancreas, Editorial Board
1991-2003 News in Physiological Sciences, Associate Editor
1992Regulatory Peptides, Editorial Board
1993-2003 Digestion, Editorial Board
1996-2001 FASEB Journal, Editorial Board
1997-2001 Associate Editor, Journal of Clinical Investigation
2001-2005 Section Editor, Annual Review of Physiology
2001-2006 Gastroenterology, Editorial Board
2003Polish Journal of Physiology & Pharmacology, Editorial Board
2010Comprehensive Physiology, Editorial Board
2011Pancreapedia, Editor-in Chief
2011Associate Editor, Gastroenterology
Referee:
American Journal of Physiology
BMC Cell Biology
British Journal of Pharmacology
Canadian Journal of Physiology and Pharmacology
Digestion
Endocrinology
European Journal of Pharmacology
European Journal of Physiology (Pflügers Archives)
Experimental Physiology
Expert Review of Proteomics
Gastroenterology
Gut
Journal of Biological Chemistry
Journal of Cell Biology
Journal of Clinical Investigation
Journal of Membrane Biology
2
John A. Williams
Journal of Physiology
Journal of Proteome Research
Life Science
Molecular Biology of the Cell
Molecular Pharmacology
Nature
Neuroendocrinology
Omics
Pancreas
Pancreatology
Peptides
Proceedings of the National Academy of Science, USA
Proteomics
Quarterly Journal of Experimental Physiology
Regulatory Peptides
Science
PLOS One
External Program Reviewer:
University of Texas Health Science Center, San Antonio
Review of Doctoral Program in Physiology, February 1990
Lovelace Medical Foundation, Albuquerque, Secretary Physiology Program, March 1992
Department of Physiology, University of Illinois, Chicago, April 1994
Physiology Graduate Program, Pennsylvania State University, November 1994
Department of Dental Research, University of Rochester, July 1997
Cell Physiology Training Grant and Graduate Program, Case Western Reserve University, December 1997
Department of Physiology, University of Florida, January 2002
Department of Cell and Molecular Physiology, University of North Carolina, May 2007.
Grant Support: (Past) JA Williams PI unless noted
NIH Grant GM-19998: Role of cell membrane in hormone secretion and action,
6/1/73-11/30/77; renewed 12/1/77-11/30/80; renewed 1/1/81-12/31/83
NIH Grant AM-21089: Regulation of pancreatic acinar function by insulin,
2/1/79-9/30/81, 10/1/81-6/30/84
NIH Grant AM-26422: Cholecystokinin and other gut hormone receptors, 12/1/79-12/31/83
Am Diabetes Association: Regulation of pancreatic exocrine function by insulin, 7/1/78-6/30/79
NIH Grant P01-AM 32994: Neurohumoral control of exocrine pancreatic cells, 1/1/84-12/31/88
Am Gastroenterological Assoc. The Pancreatic Duct Cell (Conference Grant)9/1/91-12/31/91
NIH Grant DK-45722: Role of Granule Membrane in Pancreatic Secretion, 1/15/93-12/31/97
NIH Grant DK-41225: Receptors for CCK and other GI hormones, 9/30/94-6/30/02
(Craig D Logsdon, PI)
Culpeper Foundation: Initiation of a Center for Integrative Biology and Genomics, 1/1/99-12/31/02
NIH Grant R01 DK-52860: Novel Kinase Signaling Cascades in Pancreatic Acini,
6/1/98-5/31/03 (extended to 2/01/04)
NIH Grant R01 DK-41122: Calcium and pancreatic stimulus-secretion coupling, 12/01/89-11/30/05
Grant Support: (Current) JA Williams PI unless noted
NIH Grant T32 GM-08322: Training in Systems & Integrative Biology, 7/1/92-6/30/16
NIH Grant R37 DK-41122: Calcium and pancreatic stimulus-secretion coupling,
12/01/05-11/30/15 (Awarded MERIT Status)
NIH Grant R01 DK-59578: Dietary Regulation of Pancreatic Digestive Enzymes, 12/1/02-11/30/13
NIH Grant P30 DK-34933: Digestive Disease Research Core Center (PI C. Owyang) Assoc. Director
Of Center and Director Cell Biology and Imaging Core 11/01/87-11/30/15
NIH Grant P60 DK-20572 Michigan Diabetes Research and Training Center (PI W. Herman) Director
Morphology and Image Analysis Core 12/01/96-11/30/12 Renewal to be funded.
NIH Grant G13 LM010912-01 Implementation of a pancreas knowledgebase, 9/15/12 – 9/14/15
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John A. Williams
HONORS:
1964 Roche Award - Outstanding pre-clinical student, University of Washington
1967 Alpha Omega Alpha
1968 Robert H. Williams Prize for Medical Research, University of Washington
1985 Hoffman LaRoche Prize in Gastrointestinal Physiology, American Physiological Society
1990 Who's Who in America
1998 Fellow, American Association for the Advancement of Science
1999 Ismar Boas Medal, German Gastroenterological Association
2002 Horace Davenport Lecture, American Physiological Society
2003 Distinguished Lecturer in Physiology, Medical College of Virginia
2004 Distinguished Faculty Achievement Award, University of Michigan
2005 V.L.W. Go Lifetime Achievement Award in Pancreatology, American Pancreatic Association
2008 Frank Brooks Memorial Lecture, American Pancreatic Association
2009 Horace W.Davenport Collegiate Professor of Physiology, Univ of Michigan
2009 Distinguished Alumni Award, Central Washington University
2010 Distinguished Service Award, Association of Chairs of Departments of Physiology
2012 Distinguished Mentor Award, AGA Pancreatic Disease Section
2012 George Palade Memorial Lecture, International Association of Pancreatology
MEMBERSHIPS AND OFFICES IN PROFESSIONAL SOCIETIES:
Endocrine Society
American Physiological Society
American Society for Cell Biology
American Society for Clinical Investigation
American Association for the Advancement of Science
American Pancreatic Association
American Gastroenterology Association
Association of American Physicians
1975
1979
1984
1981-1984
1985-1986
1984-1987
1985-1987
1986
1986
1987-1989
1988-1998
1989
1989-1990
1989-1990
1991
1992-1994
1993-1995
1994-1995
1996-1999
1998
1999
Local Chair, American Physiological Society Meeting, San Francisco
Co-Chair, NIH Conference, "Frontiers in Pancreatic Physiology," Reston, VA
National Committee, Fifth International Symposium on GI Hormones
Councilor, American Pancreatic Association
President, American Pancreatic Association
External Advisory Committee, Michigan Gastrointestinal Peptide Research Center
Steering Committee, American Physiological Society: Gastrointestinal Physiological
Section, 87, Chairperson, 1988-91
International Advisory Committee, Third International Conference on Intestinal
and Pancreatic Adaptation. Titisee, West Germany
Organizer, American Pancreatic Association Workshop, "Gut-Islet-Pancreatic Acinar
Interactions," Chicago, IL
AGA/Research Scholar Award Committee, Am Gastroenterological Association
External Advisory Committee, Stanford University Digestive Disease Center
Steering Committee: CLAB/UNESCO International Workshop, "Advances in
Gastrointestinal Physiology in Health and Disease," IVIC, Caracas, Venezuela
Nominating Committee, American Gastroenterological Association
Nominating Committee, American Physiological Society
Co-Chair, NIH Conference, "The Pancreatic Duct Cell," Baltimore, MD
FASEB Publications Committee
Publications Committee, American Physiological Society
FASEB Journal Editor Search Committee
Council, American Physiological Society
Local Organizing Committee, 12th International Symposium on Regulatory Peptides
International Organizing Committee, Frontiers in Pancreatic Physiology,
4
John A. Williams
1999-2000
2000-2001
2000-2002
2002-2005
2002-2006
2006-2009
2006-2007
2006-2007
2007-2009
2010-2013
Lüneburg, Germany, July 1999
Organizing Committee, Joint Meeting of Scandinavian Physiological Society and
American Physiological Society, Stockholm, Aug 2000
Organizing Committee, “The Mechanism of Pancreatitis-Between Bedside and
Laboratory,” Kitakyushu, Japan, July 2001
Long Range Planning Committee, American Physiological Society
President-Elect, President, Past-President, American Physiological Society
IUPS, National Organizing Committee
Research Policy Committee, American Gastroenterological Association
Chair, Long Range Planning Committee, American Physiological Society
Chair, Task Force on Governance, American Physiological Society
Book Committee, American Physiological Society
Ray Daggs Award Selection Committee, American Physiological Society
5
John A. Williams
CLASSROOM TEACHING:
University of California, San Francisco
1973-1974
Physiology 230, Cell Physiology
1074-1980
Human Biology 200, Cell Biology
1974-1979
Physiology 101, Endocrinology
Physiology 210, Cellular Mechanisms of Hormone Secretion
1975, 1977, 1979, 1981, 1983, 1985
1975-1983
Endocrinology 202, Mechanisms of Hormone Action
1981-1982
Anatomy 215, Cell Structure and Function
1982-1987
Physiology 120, Mammalian Physiology (Endocrinology and GI Physiology)
1983-1984
Physiology 101, Gastrointestinal Physiology
1982-1986
Physiology 211, Membrane Permeability and Transport
University of Michigan, Ann Arbor
1988
Physiology 502, Mammalian Physiology
1989, 91-92, Physiology 500, Medical Physiology (Gastrointestinal Physiology) 8-10 lectures
1996-present M1 Physiology lectures, (Gastrointestinal Block GAS 508) 8-9 lectures, 1 conference
Block Director Fall 2010-present
1989, 1991
Physiology 650, Gastrointestinal Physiology
1992, 1999
Physiology 590, Molecular and Cellular Endocrinology
1994-2004
M2 Year Gastrointestinal Block 3 lectures
1995-1999
Physiology 606, 4-6 hrs on Research Ethics
1994-1996
Physiology 510, Systems & Integrative Physiology, Endocrine Physiology
1999
Physiology 510, Systems & Integrative Physiology, Gastrointestinal Physiology
1999-2003
PIBS 503, Responsible Conduct of Research (Course Organizer, lecturer, and small group
facilitator)
2004-2006
Physiology 502, Mammalian Physiology (Lectures on Gastrointestinal Physiology)
STUDENTS AND FELLOWS SUPERVISED:
Douglas Chandler, PhD Candidate, 1973-77
(PhD awarded 1977)
Samuel Malayan, Graduate Student,
Summer Research Project, 1973
Steve Fink, MS Candidate, 1974-75
(MS awarded 1975)
Jorgen Poulsen, MD, Postdoctoral Fellow, 1975-77
Current Position
Professor of Zoology, Arizona State University
Unknown
Unknown
Medical Education Unit, University of Copenhagen,
Denmark
Reader, Medical Biochemistry, Cardiff University
School of Medicine
Professor & Chair, Internal Medicine, Dartmouth
University
Robert Dormer, PhD, Postdoctoral Fellow, 1977-79
Murray Korc, MD, Associate Investigator, VA
1977-79 (with Dr. Ira Goldfine) and 1979-80 Fellow,
Juvenile Diabetes Association
Hariharan Sankaran, PhD, Postdoc Fellow, 1978-81
BC Ponnappa, PhD, Postdoctoral Fellow, 1978-80
Unknown
Associate Professor of Pathology, Jefferson Medical
College
Yasuhiko Iwamoto, MD, Postdoctoral Fellow,
Professor of Medicine, Tokyo Women’s Medical
1978-79 (with Dr. Ira Goldfine)
University, Japan
Atsushi Saito, DVM, Postdoctoral Fellow, 1979-81
Professor, Obihiro Veterinary College, Japan
Makoto Otsuki, MD, Research Associate, 1980-82
Professor and Chair of Medicine (Emiritus), Univ
Occupational & Envir Health, Kitakyushu, Japan
Margaret Preissler, PhD, Postdoctoral Fellow, 1980-82 Unknown
Ronald Steigerwelt, PhD Candidate, 1980-84
Unknown
(PhD awarded 1984)
Daniel Burnham, PhD, Postdoctoral Fellow, 1980-83; Gastrointestinal Pharmacologist, SKF Laboratories,
Research Associate, 1983-86
Philadelphia, PA
Craig Logsdon, PhD, Postdoctoral Fellow, 1981-83;
Professor of Cancer Biology, MD Anderson Cancer
Research Associate, 1983-84
Center, Houston, TX
Choitsu Sakamoto, MD, Research Associate, 1982-83
Professor of Medicine, Nippon Medical School,
6
John A. Williams
Tokyo, Japan
Professor of Medicine, Duke University, Durham, NC
Professor of Physiology, Michigan State University
Unknown
Professor and Chair, Internal Medicine, University of
Leipzig, Germany
LaVergne Veterinary Clinic, LaVergne, Tennessee
Consultant, Mississauga, Ontario
Roger Liddle, MD, Postdoctoral Fellow, 1982-84
Seth Hootman, PhD, Research Associate, 1982-83
Dexter Louie, PhD, Visiting Postdoctoral Fellow, 1982
Jochim Mossner, MD, Postdoctoral Fellow, 1983-85
Duane Ochs, PhD, DVM, Postdoctoral Fellow, 1983-84
Jaroslaw Szecowka, PhD, Postdoctoral Fellow, 198385 (with Dr. Ira Goldfine)
Yoshinori Okabayashi, MD, Postdoctoral Fellow,
1984-86
Chin Sung, PhD, Postdoctoral Fellow, 1984-87
Robert DeLisle, PhD, Postdoctoral Fellow, 1984-88
Assistant Professor of Medicine, Kobe University,
Japan
Unknown
Professor of Cell Biology, University of Kansas
Medical School
Retired
Jin-Chao Zhang, MD, Postdoctoral Fellow, 1985-86
(with Dr. Craig Logsdon)
Christiane Sussini, PhD, Visiting Research Associate,
1985
Edward Stuenkel, PhD, Postdoctoral Fellow, 1985-88
Yoshiaki Habara, DVM, PhD, Postdoctoral Fellow,
1985-86 (with Dr. Seth Hootman)
Laura D Lewis, PhD Candidate, 1986-89 (PhD
awarded 1989); Postdoctoral Fellow, 1989-90
Janice Guthrie, PhD Candidate, 1986-88
William Putnam, MD, Postdoctoral Fellow, 1986-87
Stefan Rosewicz, MD, Postdoctoral Fellow, 1987-89
(with Dr. Craig Logsdon)
Takashi Matozaki, MD, PhD, Postdoctoral Fellow,
1988-90
Yashiro Tsunoda, PhD, Postdoctoral Fellow, 1988-90
Soren Sheikh, MD, Postdoctoral Fellow, 1988-89
Scientific Director, INSERM U 151, Toulouse, France
Professor of Physiology, University of Michigan
Department of Physiology, Asahikawa Medical
College, Japan
Research Associate, University of Michigan
Patent Law
Private Practice, Gastroenterology, Seattle, WA
Deceased
Professor, Institute of Cellular Regulation, Gunma
University, Japan
Deceased
Professor and Chair, Biochemistry, Pharmacology &
Genetics, University of S Denmark, Odense
Staff Scientist INSERM U151, Toulouse, France
Professor and Chair of Medicine, University of
Munich, Germany
Associate Professor of Medicine, Nagoya University,
Japan
Physician
Staff Physician, VA Medical Center, Washington, DC
Marie Bastié, PhD, Postdoctoral Fellow, 1988-89
Burkhardt Göke, MD, Postdoctoral Fellow, 1989-91
Motoji Kitagawa, MD, Postdoctoral Fellow, 1989-90
(with Dr. R.C. De Lisle)
Li Lu, PhD Candidate, Research Rotation, 1990
Jun Yang, PhD Candidate, 1990, 1991-1994 (PhD
awarded 1994)
Guy Groblewski, PhD, Postdoctoral Fellow, 19911997
Andreas Wagner, MD, Postdoc Fellow, 1991-1993
Matthew Wishart, PhD Candidate, 1992-2000
Sabine Mulders, Visiting PhD Student (Nijmegen,
Netherlands) 1992
Rui-Dong Duan, MD, PhD, Postdoctoral Fellow,
1992-1994
Yijun Guo-PhD Candidate, Research Rotation, 1993
Andrzej Dabrowski, MD, PhD, Postdoctoral Fellow
1994-1996
Jason Hwang, Inteflex Summer Research Student,
1994
Julia Bragado, PhD, Postdoctoral Fellow, 1995-1998
Associate Professor, Nutritional Sciences, University
of Wisconsin
Deceased
Assistant Professor, OB/GYN, University of Michigan
Unknown
Associate Professor, Lund University, Sweden
Unknown
Professor of Medicine, Vice Rector, Medical
Academy, Bialystock, Poland
Unknown
Research Assistant Professor, Biochemistry,
Veterinary & Biochemistry, School, University
Extremadura, Spain
Professor and Chair of Medicine, Akita University,
Japan
Unknown
Hirohide Ohnishi MD, PhD, Postdoctoral Fellow,
1995-1997
Christina Paz-von Friesen, Visiting PhD Student
7
John A. Williams
(Lund, Sweden with Dr. Craig Logsdon) 1996
Sarah Ross, PhD Student, Research Rotation, 1996
Assistant Professor of Neuroscience, University of
Pittsburgh
Claus Shäfer, MD -Postdoctoral Fellow, 1996-1999
Assistant Professor of Medicine, University of
Munich, Germany
Postdoctoral Fellow, Bioengineering, University of
Michigan
Unknown
Mutsumi Yoshida, Undergraduate Summer Research
Student, 1996, 1997
Arthur Peitsch, Undergraduate Summer Research
Student, 1997
Mitsuo Tashiro, MD, Postdoctoral Fellow, 19982000
Xuequn Chen, PhD Candidate, 1998-2003
Research Asst Professor, 2006-2010
Dolors Sans, PhD, Postdoctoral Fellow 1999- 2004
Occupational Medicine Physician, Matsushita
Corporation, Japan
Assistant Professor of Wayne State University
Research Assistant Professor, Molecular & Integrative
Physiology, University of Michigan
Assistant Prof of Medicine, University of Michigan
Matt DiMagno, MD, Postdoctoral Fellow 1999-2001
(with Dr. Chung Owyang)
Yan Bi, PhD Student Research Rotation, PhD
Candidate 2001-2005
Cynthia Brunkan, PhD Student, Research Rotation
2001
Chenwei Li, PhD, Postdoctoral Fellow, 2002-2004
Lili Guo, PhD Student Research Rotation, 2002, PhD
Candidate, 2003-2007
Greg Gurda, MSTP Student, Research Rotation, 2003,
PhD Candidate, 2004-2010
Lina Karam, MD, Postdoctoral Fellow, 2003-2005
Joo Weon Lim,PhD, Postdoctoral Fellow, 2004-2006
Stephen Crozier, PhD, Postdoctoral Fellow, 20042009
Maria Eugenia Sabbatini, PhD, Postdoctoral Fellow,
2006Lauren E. Ginsburg, Undergraduate Res 2006-2007
Gulnaz Khan, MD, Resident Research Rotation 2008
Yanan Hou, PhD, Postdoctoral Fellow, 2009Adam Killian, Undergraduate Res 2008
Jackie Wang, UndergradRes,2009,2010,2011,2012
Caitlyn Tivy, Undergraduate Res, Summer 2009
Ruchi Amin, Undergraduate Res, Summer 2010
Bryan Holtz, PhD Student, 2010Kevin Lodewyk, Undergraduate Res, Summer 2011
Bailey Mantha-Nagrant, Undergrad Res, Summer 2012
Resident in Internal Medicine, University of Texas,
Austin; GI Fellow Mayo Clinic 7/1/11
Research Assistant, Washington University, St. Louis
Research Associate, Surgery, University of Michigan
Postdoctoral Fellow, Joslin Diabetes Center, Boston
Resident in Pathology, Johns Hopkins Medical School
Clinical Lecturer, Pediatrics, University of Michigan
Research Associate, Yonsei University, Seoul, Korea
Nutrition Scientist, Hershey Foods
Current Trainee
University of Michigan Undergraduate Student
Medical Resident, Detroit Medical Center
Current Trainee
Medical Student, Michigan State University
Medical Student, University of Chicago
Denver University Undergraduate Student
Medical Student, Wayne State University
Current Trainee
Kalamazoo College Undergraduate Student
Purdue University Undergraduate Student
DISSERTATION COMMITTEES (University of Michigan)
Xueyan Wang, Physiology
Cassandra Constantino, Physiology
Marc Post, Physiology
Hsiao-Hwa Lu, Pharmaceutics
Daniel Terbush, Pharmacology
Yi-Jun Guo, Physiology
Li Lu, Physiology
R. Kyle Palmer, Pharmacology
Joseph B. Thompson, Pharmacology
Jun Yang (Chair)
Matthew Wishart, Physiology (Co-Chair)
Sarah Ross, Physiology
Shian-Huey Chiang, CMB
8
John A. Williams
Yi-Feng Jia, CMB
Xuequn Chen, Physiology (Chair)
Jesse Myers, CMB
Karen Hinkle, Physiology
Siobhan Armstrong, Physiology
Michael H. Roh, Biological Chemistry
Yan Bi, Physiology (Chair)
Cheryl A. Deguzman, Toxicology
Lymari Lopez-Diaz, CMB
Sona Kang, Physiology
Lili Guo, Physiology (Chair)
Matthew Merrins, Physiology
Greg Gurda, Physiology (Chair)
Xiao-Wei Chen, Physiology
Tingting Xiong, Physiology
Maeran Uhm, Physiology
Melissa McGill, CMB
Christina Scanlon, Oral Health Sciences
Meredith Collians, CMB
COMMITTEE AND ADMINISTRATIVE SERVICES:
University of California - San Francisco (selected)
1975-1987
Vice-Chair, Department of Physiology
1981-1984
Member, Graduate Council, UCSF
1977-1979
Member, Faculty Council, School of Medicine
University of Michigan Medical School
1987-2008
Chair, Department of Physiology
1987-2008
Deans Advisory Committee
1988Member, Graduate Program in Cell and Molecular Biology
1988-1991
Biomedical Research Council
1988-2000
Clinical Research Center, Policy Committee
1988-2008
Policy Committee, Michigan Medical Scientist Training Program
1988Michigan Gastrointestinal Peptide Center Executive Committee
1989-1991
Development Advisory Committee
1990-2002
Geriatrics Center Steering Committee
1990-1993
Mental Health Research Institute Advisory Committee
1991-1993
Chair, Search Committee for Department of Pharmacology Chair
1992Director, Systems and Integrative Biology Training Grant
1993Associate Director, Michigan Gastrointestinal Peptide Center
1995
Search Committee, Mental Health Research Institute Director
1995-1996
Rackham Divisional Board (I)
1998-2008
PIBS Operating Committee
1999
UMHS Strategic Planning Committee
2000-2001
Acting Director, Center for Integrative Genomics
2000-2003
Executive Committee, School of Medicine
2002-2003
Search Committee, Institute of Gerontology Director
2002-2004
Chair, Endowment for the Basic Sciences Operating Committee
2004-2008
Endowment for the Basic Sciences Operating Committee
2004-2008
Biological Scholars Search Committee
2005-2009
Faculty Search Committee, Biogerontology
2005-2008
Executive Committee, Michigan Comprehensive Diabetes Center
2005-2009
Advisory Committee, Nathan Shock Center
2005-2006
Search Committee, Brehm Center Director
2006-2009
Faculty Search Committee, Computational Biology
2006-2009
Executive Committee, Michigan Metabolomics and Obesity Center
2008-2011
Interim Director, Center for Integrative Genomics
2008-2009
Center for Organogenisis Review Committee
9
John A. Williams
20082009
2009-
Chair’s Advisory Committee, Molecular & Integrative Physiology
Search Committee, Center for Organogenesis Director
Associate Chairs for Research representing Molecular & Integrative Physiology
INVITED LECTURES (1984-present):
"Regulation of Pancreatic Acinar Cell Function by Insulin and Other Islet Hormones," Research Seminar, Department of Anatomy,
University of Minnesota, Minneapolis, MN, 1/11/84
"Cholecystokinin Receptors and Actions on Isolated Pancreatic Acini," Research Seminar, Department of Physiology and Cell
Biology, University of Texas Medical Center, Houston, TX, 2/1/84
"Common Features of Secretion Regulation in Exocrine Glands," Symposium Speaker, Cystic Fibrosis Foundation Conference,
"Endogenous regulation in cystic fibrosis," Port St. Lucie, Florida, 3/23/84
"Brain CCK Receptors: Binding Characteristics, Covalent Cross-linking and Evolutionary Aspects, "New York Academy of Science
Conference on Neuronal Cholecystokinin, Brussels, Belgium, 7/4/84
"Mechanism of Brain-gut Peptide Action," Main Speaker, Japanese Endocrine Society, Kobe, Japan, 11/2/84
"Calcium-mediated Regulatory Mechanisms in Pancreatic Acinar Cells," Gordon Conference, Oxnard, CA, 2/13/85
"Cholecystokinin Receptors: Binding Properties and Purification," Research Seminar, C.U.R.E., Wadsworth, VA Hospital,
Los Angeles, CA, 4/2/85
"Cholecystokinin: Receptors and Action in the Pancreas and Brain," Research Seminar, Genentech, South San Francisco, CA, 4/10/85
"Cholecystokinin: From Molecules to Man," Hoffman LaRoche Prize Award Lecture, FASEB, Anaheim, CA, 4/23/85
"Ganglionic Control of the Pancreas," Symposium Speaker, FASEB, Anaheim, CA, 4/25/85
"Receptors and Actions of Cholecystokinin in Pancreatic Islets," Research Seminar, Gastrointestinal Peptide Research Center,
University of Michigan, 6/6/85
"Cholecystokinin," Research Seminar, Department of Medicine, University of Pennsylvania, Philadelphia, PA, 10/2/85
"Stimulus-secretion Coupling in Pancreatic Acinar Cells," Research Seminar, Department of Physiology, University of Pennsylvania,
Philadelphia, PA, 10/3/85
"Regulation of Intracellular Calcium and its Role in Secretion and Transport," Gastrointestinal Research Group Symposium, Chicago,
IL, 11/4/85
"Cholecystokinin Receptors and Actions," Research Seminar, Department of Biochemistry, Purdue University, West Lafayette, IN,
11/5/85
"Stimulus-secretion Coupling in Pancreatic Acinar Cells," Research Seminar, Department of Physiology and Biophysics, University
of Southern California, Los Angeles, CA, 1/16/86
"Structural Studies of Somatostatin Receptors," Serono Symposium - Somatostatin, Washington, DC, 5/7/86
"Role of membrane receptors in adaptive growth," Third International Conference on Intestinal and Pancreatic Adaptation," Titsee,
West Germany, 6/13/86
"Cellular Actions and Human Physiology of Cholecystokinin," Research Seminar, University of Marburg, Department of Medicine,
"Marburg, Germany, 6/16/86
"Cellular Actions and Human Physiology of Cholecystokinin," Research Seminar, University of Wurzberg, Medical Polikinik,
Wurzberg, West Germany 6/19/86
"Regulation of Pancreatic Acinar Transport," Symposium Speaker, XXX International Congress of Physiological Sciences,
Vancouver, Canada, 7/13/86
"Cholecystokinin: New Insights Into an Old Hormone," Research Seminar, University of Michigan, Department of Physiology, 9/4/86
"Cholecystokinin in Human Physiology," Medical Grand Rounds, Nassau County Medical Center, East Meadow, NY, 9/25/86
"Stimulus-secretion Coupling in Pancreatic Acinar Cells," Research Seminar, Departments of Physiology and Medicine, State
University of New York, Stonybrook, NY, 9/26/86
"Neurohormonal Regulation of Pancreatic Exocrine Function" and "Cellular and molecular events in pancreatic exocrine secretion,"
Division of Gastroenterology, University of Colorado, Denver, CO, 10/13/86 and 10/14/86
"Gut-Islet-Pancreatic Acinar Interactions: Functional Overview," Symposium Speaker, Chicago, IL, 11/8/86
"Cholecystokinin: New Insights Into an Old Hormone," Research Seminar, Pennsylvania State University, Department of Physiology,
Hershey, PA, 1/3/87
"Regulation of Intracellular Calcium and Protein Phosphorylation in Pancreatic Acinar Cells," Alfred Benzon Symposium, Molecular
Mechanisms in Secretions, Copenhagen, 6/23/87
"Regulation of Pancreatic Growth: Overview," Symposium Speaker, FASEB Conference, Copper Mountain, Colorado, 7/6/87
"CCK: Receptors and Mechanism of Action," Research Seminar, Abbott Laboratories, Chicago, Illinois 3/2/88
"CCK: Receptors and Mechanism of Action," Research Seminar, Department of Physiology, Medical College of Virginia, Richmond,
VA 3/10/88
"Stimulus-Secretion Coupling in Pancreatic Acinar Cells," Research Seminar, Department of Physiology, Michigan State
"Regulation of Pancreatic Acinar Cell Secretion," Symposium Speaker, Fourth Annual North American CF Conference, Arlington,
VA, 10/6/90
"Characterization of CCK Receptors and Actions on Pancreatic Acinar Cells," FASEB Symposium, Atlanta, GA 4/23/91
"Regulation of Intracellular Messengers in Pancreatic Acinar Cells," Research Seminar, Duke University, Department of Cell Biology,
5/29/91
"CCK receptors and intracellular messengers," Research Seminar, Warner Lambert-Parke Davis, Ann Arbor, MI 12/17/91
"Stimulus-Secretion Coupling in Pancreatic Acinar Cells," Research Seminar, Wright State University, Department of Physiology and
Biophysics, 1/16/92
"Intracellular Messengers and the Control of Pancreatic Acinar Cells," Research Seminar, University of Texas Health Science Center,
San Antonio, Department of Physiology, 2/21/92
"Intracellular Messengers and Their Actions in Pancreatic Acinar Cells," American Gastroenterological Association Symposium,
University, East Lansing, Michigan 4/28/88
10
John A. Williams
"Methods of Receptor Purification," Symposium Speaker, International Association of Pancreatology, Verona, Italy 9/1/88
"Stimulus Secretion Coupling in the Pancreatic Acinar Cell," XIII International Congress of Gastroenterology, Rome, 9/3/88
"General Principles of Receptor Function," Symposium Speaker, American Motility Society, Monterey, California, 10/5/88
"Activation of Pancreatic Acinar Cells: Variations on a Common Theme," Research Seminar, University of Chicago, 1/13/89
"CCK: Receptors and Actions," Research Seminar, Eli Lilly, Indianapolis, 8/7/89
"Receptors for the Cholecystokinin-Gastrin Family of Peptides," Alfred Benzon Symposium, Neuropeptides and Their Receptors,
Copenhagen, Denmark, 8/24/89
"Stimulus-secretion Coupling," Invited Lecture, University of Texas, Southwestern Medical School, Gastroenterology Division,
Dallas, 10/19/89
"Stimulus-secretion Coupling in Pancreatic Acinar Cells," Research Seminar, Ohio State University, Department of Physiology,
1/24/90
"Stimulus-secretion Coupling in Pancreatic Acinar Cells," Research Seminar, Case Western Reserve, Department of Physiology and
Biophysics, 2/5/90
"Receptors for Gastrointestinal Hormones," March of Dimes Conference, Genetics of Gastrointestinal Disorders Dearborn, MI, 7/9/90
"Receptor Activated Second Messengers in Pancreatic Acinar Cells," Extended Lecture, 8th International Symposium on
Gastrointestinal Hormones, Timmendorfer Strand, Germany, 9/7/90San Francisco, CA, 5/11/92
"Intracellular Mechanisms in the Regulation of Pancreatic Acinar Cell Secretion," Research Seminar, University of Kansas,
Department of Anatomy and Cell Biology, 9/17/92
"Intracellular Mechanisms in the Control of Pancreatic Amylase Secretion," Research Seminar, Medical College of Ohio, Department
of Physiology and Biophysics, 2/24/93
"Intracellular Mechanisms in the Control of Pancreatic Acinar Secretion," Research Seminar, University of Göttingen, Abteilung
Klinische Biochemie, 10/7/93
"Stimulus-secretion Coupling in the Pancreatic Acinar Cell," Research Seminar, University of Münster, Institute of Medicinal
Chemistry, 10/11/93
"Stimulus-secretion Coupling in the Pancreatic Acinar Cell," Symposium of Clinical Research Unit for Gastrointestinal
Endocrinology, Marburg, Germany, 10/12/93
"Intracellular Mediators of Cholecystokinin Action on Pancreatic Acinar Cells," Research Seminar, INSERM U151, Toulouse, France,
10/14/93
"Intracellular Mediators of Cholecystokinin Action on Pancreatic Acinar Cells," Research Seminar, Faculty of Pharmacie,
Montpellier, France, 10/18/93
"Characterization of Receptors in Normal Pancreatic Cells and Transfected Cell Models," Symposium, European Pancreatic Club,
Paris, France, 10/20/93
"New Developments in the Control Mechanism of Pancreatic Acinar Cells," Invited Lecture, European Pancreatic Club, Paris, France,
10/22/93
“Intracellular Regulatory Mechanisms Activated by CCK in Pancreatic Acini,” Research Seminar, Stanford University Digestive
Disease Center, 4/23/94
"Intracellular Mediators Activated by CCK in Pancreatic Acinar Cells," Research Seminar, Hospital for Sick Children, Toronto,
Canada, 6/23/94
“Stimulus-Secretion Coupling in Pancreatic Acinar Cells,” Research Seminar,” Mayo Medical School, 12/14/94
“Regulation of Pancreatic Acinar Cell Function: A Plethora of Pathways,” GI Grand Rounds Conference, Mayo Medical School,
12/15/94
“Stimulus-secretion Coupling in Pancreatic Acinar Cells,” Wayne State University, Department of Physiology, 3/23/95
“Stimulus-secretion Coupling in Pancreatic Acinar Cells,” Rhode Island Hospital, Providence, RI, Combined GI Divisions, 5/3/95
“The MAP Kinase Cascade in Pancreatic Acinar Cells,” American Gastroenterological Association Symposium, San Diego, CA
5/16/95
“Intracellular Control Mechanisms in Pancreatic Acinar Cell Function: Isolated Acini, the Gold Standard,” 4th United European
Gastroenterology Week, Berlin, Germany, 9/19/95
“Intracellular Control Mechanisms in the Regulation of Pancreatic Acinar Cell Function,” II Department of Internal Medicine,
University of Leipzig, Leipzig, Germany, 9/21/95
“Novel Intracellular Signaling Mechanisms in Pancreatic Acini,” Research Seminar, Frederick Cancer Research and Development
Center, Frederick, MD, 11/14/95
“Signal Transduction: Cross-talk between G-Protein Coupled Receptors and Ras/Raf Activated Kinases in the Pancreas Mapping the
Pathways,” Research Seminar, University of Marburg, Germany, 6/5/96
“Stimulus Secretion Coupling in Pancreatic Acini,” Symposium “Future Perspectives in Gastroenterology” Leipzig, Germany, 6/7/96
“Novel Signaling Pathways Regulating Pancreatic Growth, Differentiation and Gene Expression,” Comfort Symposium on Pancreatic
Carcinogenesis, Mayo Clinic, 9/12/96
“Novel Signaling Pathways Which May Regulate Pancreatic Growth, Gene Expression, and Protein Synthesis,” Symposium, Frontiers
in Pancreatic Physiology 1996, Lincolnshire, IL, 11/9/96
“Novel Kinase Signaling Cascades in Pancreatic Acinar Cells,” Symposium, Frontiers in Pancreatic Research: From Basics to Clinics.
Nagoya, Japan, 4/19/97
“Stimulus-secretion Coupling in the Pancreas,” Research Seminar, 3 rd Department of Medicine, University of Environmental and
Occupational Health, Kita-Kyushu, Japan, 4/23/97
“GP-3, A Membrane Associated Glycosylated Lipase in Pancreatic Zymogen Granules,” FASEB Summer Conference on Intestinal
Lipid Absorption, Saxtons River, VT, 7/29/97
“Stimulus-response Coupling in Pancreatic Acinar Cells: What Happens After Calcium Increases?” Research Seminar, Department of
Physiology & Biophysics, Case Western Reserve University, Cleveland, OH 12/15/97
“Intracellular Regulation of Pancreatic Digestive Enzyme Synthesis and Secretion,” Research Seminar, Department of Physiology and
Biophysics, University of Alabama, Birmingham, AL, 5/5/99
“Intracellular Regulation of Pancreatic Digestive Enzyme Synthesis and Secretion,” Research Seminar, Beth Israel Hospital, Harvard
Medical School, Boston, MA 7/9/99
11
John A. Williams
“Intracellular Regulation of Pancreatic Digestive Enzyme Synthesis and Secretion,” Research Seminar, Department of Medicine,
University of Kiel, Germany, 7/27/99
“Regulation of Pancreatic Protein Synthesis,” Symposium Presentation, European Pancreatic Club, Lüneburg, Germany, 7/29/99
“Regulation of Synthesis and Secretion of Pancreatic Digestive Enzymes,” Department of Medicine, University of Berne, Switzerland,
9/22/99
“Stimulus-Secretion Coupling,” Ismar Boas Medal Lecture, German Gastroenterological Association, Leipzig, Germany, 9/24/99
“Regulation of Synthesis and Secretion of Pancreatic Digestive Enzymes,” Research Seminar, Department of Biology, Eastern
Michigan University, 10/20/99
“Cellular Mechanisms Regulating the Synthesis and Secretion of Digestive Enzymes by Pancreatic Acinar Cells,” Departments of
Physiology and Nutritional Sciences, University of Wisconsin, Madison, 3/2/00
“Coordinate Regulation of Pancreatic Digestive Enzyme Synthesis and Secretion by Cholecystokinin.” Symposium Seminar,
Frontiers in Physiology. Joint Meeting of the Scandinavian and American Physiological Societies. Stockholm, Sweden, 8/17/00
“Regulation of the Synthesis and Secretion of Digestive Enzymes by Pancreatic Acinar Cells,” Research Seminar, Department of
Physiology and Biophysics, University of Uppsala, Sweden, 8/21/00
“Regulating the Supply of Pancreatic Digestive Enzymes: Control of Protein Translation and Pancreatic Growth,” Research Seminar,
Division of Gastroenterology, University of California, San Diego, 1/29/01
“Regulating the Supply of Pancreatic Digestive Enzymes through Translation Control and Pancreatic Growth,” Research Seminar,
Department of Cellular and Molecular Physiology, Pennsylvania State University, Hershey, 2/27/01
“PI3-K mTOR and p70S6K in Regulation of Protein Synthesis,” Symposium contribution in “Net Intracellular Pathways Regulating
Pancreatic Acinar cells,” Digestive Disease Week 2001, Atlanta, Georgia, 5/22/01
“Stress Kinases and Heat Shock Proteins in Pancreatitis,” Symposium Presentation, “The Mechanism of Pancreatitis—Between
Bedside and Laboratory,” Kitakyushu, Japan, 7/14/01
“Regulating the Pancreatic Cytoskeleton: Role of G-proteins, Kinases and Small HSP,” Research Seminar, Diabetes Center, Tokyo
Women’s Medical University, Tokyo, Japan, 7/16/01
“Regulating the Synthesis and Secretion of Pancreatic Digestive Enzymes,” Research Seminar, Department of Physiology, University
of Tennessee, Memphis, 3/8/02
“Regulating the Synthesis of Pancreatic Digestive Enzymes Through Translational Control,” 2 nd International Symposium, Frontiers
in Pancreatic Research: From Basis to Clinics, Nagoya, Japan, 3/30/02
“Regulation of the Synthesis and Secretion of Pancreatic Digestive Enzymes by Diet and Hormones,” Horace Davenport Lecture,
American Physiological Society, EB 2002, New Orleans, 4/23/02
“CCK Receptor Activation: Signal Transduction,” Symposium Speaker, “Structure and Function of CCK Receptors” Copenhagen,
Denmark, 5/24/02
“Regulation of the Synthesis and Secretion of Pancreatic Digestive Enzymes by Diet and Hormones” Research Seminar, Department
of Gastroenterology, University of Lund, Sweden, 5/27/02.
“Regulating the Synthesis and Secretion of Pancreatic Digestive Enzymes by Diet and Hormones,” Research Seminar, Medical
University of Bialystok, Poland, 5/29/02.
“Regulation of the Synthesis and Secretion of Pancreatic Digestive Enzymes by Diet and Hormones,” Seminar, Department of
Physiology, Jagellonian University, Cracow, Poland, 6/3/02.
“Regulation of Pancreatic Growth,” Symposium Speaker, XXXV Meeting European Pancreatic Club, Liverpool, England, 6/20/03
“Regulation of Digestive Enzyme Synthesis by Pancreatic Acinar Cells, “ International Pancreas Basic Science Workshop, Liverpool,
England, 6/21/03
“Regulating the Supply of Pancreatic Digestive Enzymes, a Mealtime Affair,” Seminar, School of Biological Sciences, University of
Manchester, Manchester, England, 6/23/03
“Regulating the Supply of Pancreatic Digestive Enzymes: A Mealtime Affair,” Seventeenth Annual Distinguished Lecturer in
Physiology, Medical College of Virginia, Richmond, VA 3/04/04
“Regulating the Supply of Digestive Enzymes: A Mealtime Affair,” Seminar, Department of Physiology, University of Massachusetts
Medical School, Worcester, MA 3/15/04
“Rabs and Pancreatic Vesicular Transport,” Symposium Speaker, Digestive Disease Week, New Orleans, LA 5/17/04
“Rab Proteins Present on Zymogen Granules and their Role in Secretion,” Invited Speaker, Third Symposium on Exocrine Glands,
Korea-Japan, Seoul Korea 7/9/04
“Stimulus-Secretion Coupling in Pancreatic Acinar Cells: Roles of Small G Proteins,” Seminar, Department of Pharmacology and
Physiology, University of Rochester, Rochester, NY, 10/12/04
“Proteomics Analysis of Rat Pancreatic Zymogen Granules,” Symposium in Honor of Professor John Forte, Berkeley, CA, 2/05/05
“Activation and Action of Rho and Rac in Pancreatic Acini,” Gordon Research Conference on Salivary Glands & Exocrine Secretion,
Ventura, CA, 2/09/05
“Proteomics Analysis of Rat Pancreatic Zymogen Granules,” Gastrointestinal Research Group Spring Symposium, Chicago, IL,
5/15/05
“Intracellular Signaling Pathways of the Exocrine Acinar Cell,” Update on Pancreatic Diseases International Symposium, Munich,
Germany, 9/9/05
“Pancreatic Plasticity: Regulating the Growth of the Pancreas,” Research Seminar, Department of Physiology, University of Illinois at
Chicago, Chicago, IL, 10/13/06
“Adaptation or Extinction: The Evolution of a Physiology Department,” Invited Talk Association of Chairs of Departments of
Physiology Annual Retreat, Guanacaste, Costa Rica, 12/1/06
“Small G Proteins and the Regulation of Pancreatic Acinar Cell Secretion,” Gordon Research Conference on Salivary Glands and
Exocrine Secretion, Ventura, CA, 2/13/07
“Pancreatic Plasticity: Regulating the Growth of the Pancreas,” Molecular Medicine Research Seminar, University of Pittsburgh,
Pittsburgh, PA, 4/10/07
“Reducing the Acinar Cell to a Molecular Machine: From Here to There and Back Again,” Symposium Presentation, Understanding
the role of the Pancreas in Digestion: Placing Current Understanding in a Historical Perspective. Experimental Biology 2007,
Washington, DC, 4/30/07
12
John A. Williams
“Molecular Architecture of the Pancreatic Zymogen Granule Membrane,” European Pancreas Club Basic Science Satellite, Frontiers
in Exocrine Pancreatic Physiology & Pathophysiology, Newcastle, UK, 7/07/07
“Pancreatic Plasticity: Regulating the Growth of the Pancreas,” Research Seminar, Department of Medicine, University of Leipzig,
Leipzig, Germany, 10/09/07
“Cellular Mechanisms of Pancreatic Digestive Enzyme Secretion,” FALK Symposium 161, Future Perspectives in Gastroenterology,
Dresden, Germany, 10/12/07
“Pancreatic Plasticity: Regulating the Growth of the Pancreas,” Research Seminar, Division of Gastroenterology, University of
Washington, Seattle, WA, 9/19/08
“Pancreatic Plasticity: Nutrients as Well as GI Hormones Regulate the Size of the Pancreas”, Research Seminar, Department of
Molecular and Cellular Physiology, University of Cincinnati, Cincinnati OH, 10/07/08
“Regulation of Pancreatic Growth by Nutrients and Hormones” Frank Brooks Memorial Basic Science Lecture, American Pancreatic
Association Ann Mtg, Chicago IL, 11/06/08
“Protein Malnutrition and the Pancreas,” Symposium Speaker, Digestive Disease Week, Chicago, IL 6/02/09
“Pancreatic Plasticity: Nutrients as well as hormones regulate the size of the pancreas” Research Seminar, Department of Integrative
Biology and Physiology, University of Minnesota, Minneapolis MN, 9/17/09
“The Pancreas: Deconstructing a secretory machine to understand its function” Research Seminar, Department of Biology, Central
Washington University, Ellensburg, WA, 10/23/09
“Regulation of Protein Synthesis in the Acinar Cell”, Symposium presentation, American Pancreatic Association, Honolulu, HI Nov
2009
“Hormonal Regulation of Pancreatic Secretion”, Symposium Speaker, Digestive Disease Week, New Orleans, LA 5/04/10.
“Regulation of Digestive Enyme Secretion by Pancreatic Acinar Cells”, Research Seminar, Institute for Molecular and Cellular
Regulation, Gunma University, Maebashi Japan, 5/17/10
“Regulation of Digestive Enzyme Secretion by Pancreatic Acinar Cells” Symposium Speaker, Physiological Society of Japan,
Morioka, Japan, 5/20/10
“The Pancreapedia: a knowledgebase for the exocrine pancreas” Invited Speaker, Pancreasfest 2010, Pittsburgh PA, 7/30/10
“Deconstructing the Pancreas as a System of Cellular Machines” Invited Speaker, American Pancreatic Association, Chicago, IL Nov
2010
“Regulating the supply of digestive enzymes for secretion by pancreatic acinar cells” Invited Speaker, Frontiers in Epithelial Transport
2011, Seoul Korea, April 14-16, 2011.
“Mechanisms of pancreatic growth regulation by hormones and Nutrients”, Research Seminar, Department of Physiology, University
of Kentucky, Lexington KY 4/28/11
“Action of insulin on pancreatic acinar cells as revealed by cell specific deletion of insulin receptors”. Invited Speaker, Epithelial
receptors, signaling & secretion. Manchester, UK, September 15-16, 2011.
“Regulating the supply of digestive enzymes for secretion by pancreatic acinar cells” Research Seminar, Department of Physiology,
Wayne State University, Detroit MI 2/2/12.
“Regulating the supply of digestive enzymes for secretion by pancreatic acinar cell” Invited Speaker, 75 th Anniversary of Albert
Szent-György’s Nobel Prize Award, Szeged, Hungary, March 22-25, 2012.
“From genetics to physiology – How basic research provides insight for pancreatic disease” Plenary lecture, 118 th Congress of the
German Society for Internal Medicine, Wiesbaden Germany, April 14-17, 2012.
“Utilizing proteomics to understand acute pancreatitis” NIDDK Workshop, Advances in acute and chronic pancreatitis: from
development to inflammation and repair, Bethesda MD, June 25-26, 2012
“Regulating the supply of digestive enzymes for secretion by pancreatic acinar cells” Research Seminar, Epithelial Biology Group,
Vanderbilt University, Nashville TN 10/1/12.
“The secretory pathway for pancreatic digestive enzymes: from Palade to the present” George E Palade memorial lecture, American
Pancreatic Association, Miami FL, Nov 2, 2012.
13
John A. Williams
BIBLIOGRAPHY: Full Papers:
+
1.
Williams JA. Effect of external K concentration on transmembrane potentials of rabbit thyroid cells. Am J Physiol 211:11711174, 1966.
2.
Williams JA. Electrical polarization of thyroid follicles in the perfused rabbit thyroid gland. Am J Physiol 217:1094-1100,
1969.
3.
Williams JA. Effects of TSH on thyroid membrane properties. Endocrinology 86:1154-1158, 1970.
4.
Williams JA. Origin of the transmembrane potentials in non-excitable cells. J Theor Biol 28:287-296, 1970.
5.
Williams JA, J Wolff. Possible role of microtubules in thyroid secretion. Proc Nat Acad Sci 67:1901-1908, 1970.
6.
Williams JA, DM Woodbury. Determination of extracellular space and intracellular electrolytes of rat liver in vivo. J Physiol
212:85-99, 1971.
7.
Williams JA, CD Withrow, DM Woodbury. Effects of ouabain and diphenylhydantoin on transmembrane potentials,
intracellular electrolytes and cell pH of rat muscle and liver in vivo. J Physiol 212:101-115, 1971.
8.
Williams JA, CD Withrow, DM Woodbury. Effects of nephrectomy and KCl on transmembrane potentials, intracellular
electrolytes and cell pH of rat muscle and liver in vivo. J Physiol 212:117-128, 1971.
9.
Williams JA, J Wolff. Thyroid secretion in vitro: Multiple actions of agents affecting secretion. Endocrinology 88:206-217,
1971.
10. Williams JA, J Wolff. Thyroid secretion in vitro: Effects of membrane stabilizers. In: Further Advances in Thyroid Research,
Fellinger K and R Hofer (Eds), Wiener Medinischen Akademie, Vienna, 1971, p 677-682.
11. Williams JA, CD Withrow, DM Woodbury. Effects of CO 2 on transmembrane potentials of rat liver and muscle in vivo. J.
Physiol. 215:539-555, 1971.
12. Williams JA, SC Berens, J Wolff. Thyroid secretion in vitro: Inhibition of TSH and dibutyryl cyclic-AMP stimulated 131I
release by Li+. Endocrinology 88:1385-1388, 1971.
13. Williams JA, J Wolff. Cytochalasin B inhibits thyroid secretion. Biochem Biophys Res Commun 44:422-425, 1971.
14. Berens SC, JA Williams, J Wolff. Dissociation of thyrotropin-stimulated hormone secretion and glucose oxidation in thyroid
glands by lithium and colchicine. Biochem Biophys Acta 252:314-323, 1971.
+
+
15. Williams JA. Effects of Na and K on secretion in vitro by mouse thyroid glands. Endocrinology 90:1452-1458, 1972.
16. Williams JA. Effects of Ca
++
++
and Mg on secretion in vitro by mouse thyroid glands. Endocrinology 90:1459-1463, 1972.
17. Temple R, JA Williams, JF Wilber, J Wolff. Colchicine and hormone secretion. Biochem Biophys Res Commun 46:1454-1461,
1972.
18. Williams JA, J Wolff. Colchicine binding protein and secretion of thyroid hormone. J Cell Biol 54:157-165, 1972.
19. Benz L, B Eckstein, EK Matthews, JA Williams. Control of pancreatic amylase release in vitro: Effects of ions, cyclic AMP,
and colchicine. Br J Pharmacol 46:66-77, 1972.
20. Williams JA. Cyclic AMP formation and thyroid secretion by incubated mouse thyroid lobes. Endocrinology 91:1411-1417,
1972.
21. Matthews EK, OH Peterson, JA Williams. Pancreatic acinar cells: acetylcholine-induced membrane depolarization, calcium
efflux and amylase release. J Physiology 234:689-701, 1973.
22. Matthews EK, OH Peterson, JA Williams. Analysis of tissue amylase output by an automated method. Analytical Biochemistry
58:155-160, 1974.
23. Williams JA, EK Matthews. Effects of ions and metabolic inhibitors on membrane potential and brown adipose tissue. Am J
Physiol 227:981-986, 1974.
24. Williams JA, EK Matthews. Membrane depolarization, cyclic AMP, and glycerol release by rat brown adipose tissue. Am J
Physiol 227:987-992, 1974.
25. Chandler DE, JA Williams. Pancreatic acinar cells: effects of lanthanum ions on amylase release and calcium ion fluxes. J
Physiology 243:831-847, 1974.
14
John A. Williams
26. Williams JA, J Kemp, DM Woodbury. Distribution of inorganic sulfate between plasma, liver, and bile. Life Sciences 15:741749, 1974.
27. Williams JA, M Lee. Pancreatic acinar cells: use of Ca++ ionophore to separate enzyme release from the earlier steps in
stimulus-secretion coupling. Biochem Biophys Res Commun 60:542-548, 1974.
28. Williams JA, DE Chandler. Ca++ and pancreatic amylase release. Am J Physiol 228:1729-1732, 1975.
29. Osland RB, RV Gallo, JA Williams. In vitro release of luteinizing hormone from anterior pituitary fragments superfused with
constant or pulsatile amounts of luteinizing hormone-releasing factor. Endocrinology 96:1210-1216, 1975.
30. Williams JA, SA Malayan. Effects of TSH on iodide transport by mouse thyroid lobes in vitro. Endocrinology 97:162-168,
1975.
31. Williams JA. Na+ dependence of in vitro pancreatic amylase release. Am J Physiol 229:1023-1026, 1975.
32. Williams JA. An in vitro evaluation of possible cholinergic and adrenergic receptors affecting pancreatic amylase secretion.
Proc Soc Exp Biol Med 150:513-516, 1975.
33. Williams JA. In vitro studies on the nature of vinblastine inhibition of thyroid secretion. Endocrinology 98:1351-1358, 1976.
34. Williams JA. Stimulation of 45Ca2+ efflux from rat pituitary by luteinizing hormone-releasing hormone and other pituitary
stimulants. J Physiol 260:105-115, 1975.
35. Fink SE, JA Williams. Adrenergic receptors mediating depolarization in brown adipose tissue. Am J Physiol 231:700-706,
1976.
36. Williams JA, P Cary, B Moffat. Effects of ions on amylase release by dissociated pancreatic acinar cells. Am J Physiol
231:1562-1567, 1976.
37. Poulsen JH, JA Williams. Spontaneous repetitive hyperpolarisations from cells in the rat adenohypophysis. Nature 263:156158, 1976.
38. Williams JA, M Lee. Microtubules and pancreatic amylase release by mouse pancreas in vitro. J Cell Biol 71:795-806, 1976.
39. Poulsen JH, JA Williams. Effects of the calcium ionophore A23187 on pancreatic acinar cell membrane potentials and amylase
release. J Physiol 264:323-339, 1977.
40. Chandler DE, JA Williams. Intracellular uptake and alpha- amylase and lactate dehydrogenase releasing actions of the divalent
cation ionophore A23187 in dissociated pancreatic acinar cells. J Membrane Biology 32:201-230, 1977.
41. Williams JA, JH Poulsen, M Lee. Effects of membrane stabilizers on pancreatic amylase release. J Membrane Biology 33:185195, 1977.
42. Williams JA. Effects of cytochalasin B on pancreatic acinar cell structure and secretion. Cell and Tiss Res 179:453-466, 1977.
43. Chandler DE, JA Williams. Redistribution of cell calcium during stimulus-secretion coupling as determined by a fluorescent
probe. Nature 268:659-660, 1977.
+
44.
Poulsen JH, JA Williams. Effect of extracellular K concentration on resting potential, caerulein-induced depolarization and
amylase release from mouse pancreatic acinar cells. Pflugers Arch 370:173-177, 1977.
45.
Williams JA. The effect of the ionophore A23187 on amylase release, cellular integrity and ultrastructure of mouse pancreatic
acini. Cell Tiss Res 186:287-295, 1978.
46.
Chandler DE, JA Williams. Intracellular divalent cation release in pancreatic acinar cells during stimulus-secretion coupling. I.
Use of chlorotetracycline as fluorescent probe. J. Cell Biology 76:371-385, 1978.
47.
Chandler DE, JA Williams. Intracellular divalent cation release in pancreatic acinar cells during stimulus-secretion coupling.
II. Subcellular localization of the fluorescent probe chlorotetracycline. J Cell Biology 76:386-399, 1978.
48.
Williams JA, M Korc, RL Dormer. Action of secretagogues on a new preparation of functionally intact isolated pancreatic
acini. Am J Physiol 235:E517-524, 1978.
49.
Williams JA. Catharanthine. A novel stimulator of pancreatic enzyme release. Cell and Tiss Res 192:277-284, 1978.
50.
Korc M, H Sankaran K Wong, JA Williams, ID Goldfine. Insulin receptors in isolated mouse pancreatic acini. Biochem
Biophys Res Commun 84:293-299, 1978.
51.
Watson EL, JA Williams, IA Siegel. Calcium mediation of cholinergic stimulated amylase release from mouse parotid gland.
Am J Physiol 236:E233-237, 1979.
15
John A. Williams
52.
Korc M., JA Williams, ID Goldfine. Stimulation of the glucose transport system in isolated mouse pancreatic acini by
cholecystokinin and analogues. J Biol Chem 254:7624-7629, 1979.
53.
Sankaran H, CW Deveney, ID Goldfine, JA Williams. Preparation of biologically active radioiodinated cholecystokinin for
radioreceptor assay and radioimmunoassay. J Biol Chem 254:9349-9351, 1979.
54.
Sankaran H, ID Goldfine, CW Deveney, KY Wong, JA Williams. Binding of cholecystokinin to high affinity receptors on
isolated rat pancreatic acini. J Biol Chem 255:1849-1853, 1980.
55.
Saito A, JA Williams, T Kanno. Potentiation of cholecystokinin-induced exocrine secretion by both exogenous and
endogenous insulin in the isolated and perfused rat pancreata. J Clin Invest 65:777-782, 1980.
56.
Saito A, JA Williams, T Kanno. Potentiation by insulin of the acetylcholine-induced secretory response of the perfused rat
pancreas. Biomed Res (Tokyo) 1:101-103, 1980.
57.
Iwamoto Y, JA Williams. Inhibition of alpha-aminoisobutyric acid uptake by cholecystokinin and other secretagogues. Am J
Physiol 238:G440-444, 1980.
58. Ryu K, JA Williams, RV Gallo. Studies on a possible pituitary effect of monoamines on luteinizing hormone release in
ovariectomized rats. Life Science 27:1083-1087, 1980.
59. Saito A, H Sankaran, ID Goldfine, JA Williams. Cholecystokinin receptors in the brain: Characterization and distribution.
Science 208:1155-1156, 1980.
60. Williams JA. Multiple effects of Na+ removal on pancreatic secretion in vitro. Cell and Tiss Res 210:295-303, 1980.
61. Dormer RL, BC Ponnappa, JA Williams. Redistribution of intracellular calcium induced by pancreatic secretagogues. In:
Biology of Normal and Cancerous Exocrine Pancreatic Cells. A Ribet, L Proadayrol and C Susini. Elsevier, North Holland,
Amsterdam, 1980.
62. Ponnappa BC, JA Williams. Effects of ionophore A23187 on calcium flux and amylase release in isolated mouse pancreatic
acini. Cell Calcium 1:267-278, 1980.
63. Korc M., JA Williams, ID Goldfine. Pancreatic exocrine function and the islets of Langerhans. Int Med 1:20-23, 1980.
64. Dormer RL, JH Poulsen, V Licko, JA Williams. Calcium fluxes in isolated pancreatic acini: effects of secretagogues. Am J
Physiol 240:G38-49, 1981.
65. Dormer RL, JA Williams. Secretagogue-induced changes in subcellular Ca
Physiol 240:G130-140, 1981.
2+
distribution in isolated pancreatic acini. Am J
66. Korc M, Y Iwamoto, H Sankaran, JA Williams, ID Goldfine. Insulin action in pancreatic acini from streptozotocin-treated rats.
I. Stimulation of protein synthesis. Am J Physiol 240:G56-62, 1981.
67. Sankaran H, Y125Iwamoto, M Korc, JA Williams, ID Goldfine. Insulin action in pancreatic acini from streptozotocin-treated rats.
II. Binding of I-insulin to receptors. Am J Physiol 240:G63-68, 1981.
68. Goldfine ID, BM Kriz, KY Wong, G Hradek, AL Jones, JA Williams. Insulin action in pancreatic acini from streptozotocintreated rats III. Electron microscopic autoradiography of 125I-insulin. Am J Physiol 240:G69-75, 1981.
69. Ponnappa BC, RL Dormer, JA Williams. Characterization of an ATP-dependent Ca
microsomes. Am J Physiol 240:G122-129, 1981.
2+
uptake system in mouse pancreatic
70. Saito A, JA Williams, ID Goldfine. Alterations in brain cholecystokinin receptors after fasting. Nature 289:599-600, 1981.
71. Gallagher S, H Sankaran, JA Williams. Mechanism of scorpion toxin-induced enzyme secretion in rat pancreas.
Gastroenterology 80:970-973, 1981.
72. Korc M, AC Bailey, JA Williams. Regulation of protein synthesis in normal and diabetic rat pancreas by cholecystokinin. Am J
Physiol 241:G116-121, 1981.
73. Saito A, ID Goldfine, JA Williams. Characterization of receptors for cholecystokinin and related peptides in mouse cerebral
cortex. J Neurochem 37:483-490, 1981.
74. Ponnappa BC, JA Williams. Comparison of
pancreatic acini. Life Sci 28:2395-2402, 1981.
45
Ca
2+
uptake activity by microsomes from control and stimulated mouse
75. Saito A, JA Williams, ID Goldfine. Alterations of brain cerebral cortex CCK receptors in the ob/ob mouse. Endocrinology
109:984-986, 1981.
16
John A. Williams
76. Preissler M, JA Williams. Pancreatic acinar cell function: measurement of intracellular ions and pH and their relation to
secretion. J Physiol (London) 321:437-448, 1981.
77. Steigerwalt RW, JA Williams. Characterization of cholecystokinin receptors on rat pancreatic membranes. Endocrinology
109:1746-1753, 1981.
78. Sankaran H, AC Bailey, JA Williams. CCK4 contains the full hormonal information of cholecystokinin in isolated pancreatic
acini. Biochem Biophys Res Commun 103:1356-1362, 1981.
79. Burnham DB, JA Williams. Effects of high concentrations of secretagogues on the morphology and secretory activity of the
pancreas: a role for microfilaments. Cell and Tiss Res 222:201-212, 1982.
80. Sankaran H, ID Goldfine, A Bailey, V Licko, JA Williams. Relationship of cholecystokinin receptor binding to biological
functions in pancreatic acini. Am J Physiol 242:G250-257, 1982.
81. Saito A, JA Williams, SH Waxler, ID Goldfine. Alterations of CCK receptors in mice made obese with goldthioglucose. J
Neurochem 39:525-528, 1982.
82. Otsuki M, JA Williams. Effect of diabetes mellitus on regulation of enzyme secretion by isolated rat pancreatic acini. J Clin
Invest 70:148-156, 1982.
83. Otsuki M, JA Williams. Copper stimulates amylase release from isolated rat pancreatic acini independent of Ca
Gastroenterology 83:84-91, 1982.
84. Williams JA, H Sankaran, E Roach, ID Goldfine. Quantitative electron microscope autoradiographs of
pancreatic acini. Am J Physiol 243:G291-296, 1982.
2+.
125
I-cholecystokinin in
85. Williams JA, AC Bailey, M Preissler, ID Goldfine. Insulin regulation of sugar transport in isolated pancreatic acini from
diabetic mice. Diabetes 31:674-682, 1982.
86. Williams JA, S Gallagher, H Sankaran. Scorpion toxin-induced amylase secretion in guinea pig pancreas: evidence for a new
neurotransmitter. Proc Soc Exp Biol Med 170:384-389, 1982.
87. Otsuki M, JA Williams. Protein synthesis inhibitors enhance secretagogue sensitivity of in vitro rat pancreatic acini. Am J
Physiol 243:G285-290, 1982.
88. Burnham DB, JA Williams. Effects of carbachol, cholecystokinin and insulin on protein phosphorylation in isolated pancreatic
acini. J Biol Chem 257:10523-10528, 1982.
89. Otsuki M, JA Williams. Direct modulation of pancreatic CCK receptors and enzyme secretion by insulin in isolated pancreatic
acini from diabetic rats. Diabetes 32:241-246, 1983.
90. Preissler M, JA Williams. Localization of ATP-dependent calcium transport activity in mouse pancreatic microsomes. J
Membrane Biol 73:137-144, 1983.
91. Sakamoto C, JA Williams, KY Wong, ID Goldfine. The CCK receptor on pancreatic plasma membranes: Binding
characteristics and covalent cross-linking. FEBS Letters 151:63-66, 1983.
92. Otsuki M, JA Williams. Amylase secretion by isolated pancreatic acini after chronic cholecystokinin treatment in vivo. Am J
Physiol 244:G683-688, 1983.
93. Logsdon CD, JA Williams. Pancreatic acini in short-term culture: regulation by EGF, carbachol, insulin, and corticosterone.
Am J Physiol 244:G675-682, 1983.
94. Logsdon CD, JA Williams. Epidermal growth factor binding and biological effects on mouse pancreatic acini. Gastroenterology
85:339-345, 1983.
+
+
95. Hootman SR, SA Ernst, JA Williams. Secretagogue regulation of Na -K pump activity in pancreatic acinar cells. Am J Physiol
245:G339-346, 1983.
96. Sakamoto C, ID Goldfine, JA Williams. Characterization of cholecystokinin receptor subunits on pancreatic plasma
membranes. J Biol Chem 258:12707-12711, 1983.
97. Williams JA, A Bailey, RW Steigerwalt. Effects of proglumide on pancreatic acinar cell function. Digestion 27:227-233, 1983.
98. Iwamoto Y, E Roach, A Bailey, JA Williams, ID Goldfine. The effect of chloroquine on the binding, intracellular distribution
and action of insulin on isolated mouse pancreatic acini. Diabetes 32:1102-1109, 1983.
99. Ochs DL, JI Korenbrot, JA Williams Intracellular free calcium concentrations in isolated pancreatic acini; effects of
secretagogues. Biochem Biophys Res Commun 117:122-128, 1983.
17
John A. Williams
100. Logsdon CD, JA Williams. Epidermal growth factor: intracellular Ca
cells. FEBS Letters 164:335-339, 1983.
2+
inhibits its association with pancreatic acini and A431
101. Goldfine ID, JA Williams, AC Bailey, KY Wong, Y Iwamoto, K Yokono, S Baba, RA Roth. Degradation of insulin by isolated
mouse pancreatic acini: evidence for cell surface protease activity. Diabetes 33:64-72, 1984.
102. Sakamoto C, ID Goldfine, JA Williams. Pancreatic CCK receptors: Characterization of covalently labeled subunits. Biochem
Biophys Res Commun 118:623-628, 1984.
103. Burnham DB, DJ McChesney KC Thurston, JA Williams. Interaction of cholecystokinin and vasoactive intestinal polypeptide
on function of mouse pancreatic acini in vitro. J Physiol 349:475-482, 1984.
104. Williams JA, A Bailey, R Humbel, ID Goldfine. Insulin-like growth factors bind to specific receptors in isolated pancreatic
acini. Am J Physiol 246:G96-99, 1984.
105. Steigerwalt RW, JA Williams. Binding specificity of the mouse cerebral cortex receptor for small cholecystokinin peptides.
Regulatory Peptides 8:51-59, 1984.
106. Sakamoto C, JA Williams, E Roach, ID Goldfine. In vivo localization of insulin binding to cells of the rat pancreas (41827).
Proc Soc Exp Biol Med 175:497-502, 1984.
107. Potau N, J Mossner, JA Williams, ID Goldfine. Cholecystokinin and insulin regulate insulin-like growth factor II binding to
pancreatic receptors: evidence for a role for intracellular calcium. Biochem Biophys Res Commun 119:359-364, 1984.
108. Burnham DB, JA Williams. Activation of protein kinase activity in pancreatic acini by calcium and cAMP. Am J Physiol
246:G500-508, 1984.
109. Otsuki M, Y Okabayashi, A Ohki, SR Hootman, S Baba, JA Williams. Amylase secretion by isolated pancreatic acini after
acute cholecystokinin treatment in vivo. Am J Physiol 246:G419-425, 1984.
110. Potau N, AC Bailey, E Roach, JA Williams, ID Goldfine. Methylamine and monensin do not block insulin internalization but
do influence the intracellular distribution and action of insulin in pancreatic acini from diabetic mice. Endocrinology 115:205213, 1984.
111. Liddle R, ID Goldfine, JA Williams. Bioassay of plasma cholecystokinin in rats: effects of food, trypsin inhibitor, and alcohol.
Gastroenterology 87:542-549, 1984.
112. Sakamoto C, ID Goldfine, JA Williams. The somatostatin receptor on isolated pancreatic acinar cell plasma membranes:
identification of subunit structure and direct regulation by cholecystokinin. J Biol Chem 259:9623-9627, 1984.
113. Mossner J, CD Logsdon, ID Goldfine, JA Williams. Regulation of pancreatic acinar cell insulin receptors by insulin. Am J
Physiol 247:G155-160, 1984.
2+
114. Logsdon CD, JA Williams. Intracellular Ca and phorbol esters synergistically inhibit internalization of epidermal growth
factor in pancreatic acini. Biochem J 223:893-900, 1984.
2+
115. Mossner J, CD Logsdon, N Potau, JA Williams, ID Goldfine. Effect of intracellular Ca on insulin-like growth factor II
internalization into pancreatic acini: Roles of insulin and cholecystokinin. J Biol Chem 259:12350-12356, 1984.
116. Otsuki M, ID Goldfine, JA Williams. Diabetes in the rat is associated with a reversible postreceptor defect in cholecystokinin
action. Gastroenterology 87:882-887, 1984.
117. Steigerwalt RW, ID Goldfine, JA Williams. Characterization of cholecystokinin receptors on bovine gall bladder membranes.
Am J Physiol 247:G709-G714, 1984.
118. Vigna SR, RW Steigerwalt, JA Williams. Characterization of cholecystokinin receptors in bullfrog (Rana catesbeiana) brain
and pancreas. Regulatory Peptides 9:199-212, 1984.
119. Sakamoto C, JA Williams, ID Goldfine. Brain CCK receptors are structurally distinct from pancreas CCK receptors. Biochem
Biophys Res Commun 124:497-502, 1984.
120. Hootman SR, JA Williams. Sodium-potassium pump in guinea-pig parotid gland: Secretagogue stimulation of ouabain binding
to dispersed acini. J Physiol 360:121-134, 1985.
121. Sakamoto C, ID Goldfine, E Roach, JA Williams. Localization of saturable CCK receptors in rat pancreatic islets by light and
electron microscope autoradiography. Diabetes 34:390-394, 1985.
122. Liddle RA, ID Goldfine, MS Rosen, RA Taplitz, JA Williams. Cholecystokinin bioactivity in human plasma: molecular forms,
response to feeding, and relationship to gallbladder contraction. J Clin Invest 75:1144-1152, 1985.
18
John A. Williams
123. Szecowka J, ID Goldfine, JA Williams. Solubilization and characterization of CCK receptors from mouse pancreas. Regulatory
Peptides 10:71-83, 1985.
124. Logsdon CD, J Moessner, JA Williams, ID Goldfine. Glucocorticoids increase amylase mRNA levels, secretory organelles, and
secretion in pancreatic acinar AR42J cells. J Cell Biol 100:1200-1208, 1985.
125. Ochs DL, JI Korenbrot, JA Williams. Relationship between free cystosolic calcium and amylase release by pancreatic acini.
Am J Physiol 249:G389-398, 1985.
126. Moessner J, CD Logsdon, JA Williams, ID Goldfine. Insulin, via its own receptor, regulates growth and amylase synthesis in
pancreatic acinar AR42J cells. Diabetes 34:891-897, 1985.
127. Burnham DB, P Munowitz, N Thorn, JA Williams. Protein kinase activity associated with pancreatic zymogen granules.
Biochem J 227:743-751, 1985.
128. Vigna SR, J Szecowka, JA Williams. Do antagonists of pancreatic cholecystokinin receptors interact with central nervous
system cholecystokinin receptors? Brain Research 343:394-397, 1985.
+
+
129. Hootman SR, OL Ochs, JA Williams. Intracellular mediators of Na -K pump activity in guinea pig pancreatic acinar cells. Am
J Physiol 249:G470-478, 1985.
130. Louie DS, JA Williams, C Owyang. Action of pancreatic polypeptide on rat pancreatic secretion: in vivo and in vitro. Am J
Physiol 249:G489-495, 1985.
131. Verspohl EJ, HPT Ammon, JA Williams, ID Goldfine. Evidence that cholecystokinin interacts with specific receptors and
regulates insulin release in isolated rat islets of Langerhans. Diabetes 35:38-43, 1986.
132. Nguyen TD, JA Williams, GM Gray. Vasoactive intestinal peptide receptor on liver plasma membranes: characterization as a
glycoprotein. Biochemistry 25:361-368, 1986.
133. Liddle RA, ET Morita, CK Conrad, JA Williams. Regulation of gastric emptying in humans by cholecystokinin. J Clin Invest
77:992-996, 1986.
134. Logsdon CD, JA Williams. Pancreatic acinar cells in monolayer culture: Direct trophic effects of caerulein in vitro. Am J
Physiol 250:G440-447, 1986.
135. Burnham DB,
P Munowitz, SR Hootman, JA Williams. Regulation of protein phosphorylation in pancreatic acini. Distinct
2+
effects of Ca ionophore A23187 and 12-O-tetradecanoylphorbol 13-acetate. Biochem J 235:125-131, 1986.
136. Moessner J, E Roach, ID Goldfine, JA Williams. Autoradiographic analysis of
into pancreatic acini. Diabetes Res Clin Prac 2:75-82, 1986.
125
I-insulin-like growth factor II internalization
137. Verspohl EJ, G Wunderle, HPT Ammon, JA Williams, ID Goldfine. Proglumide (gastrin and cholecystokinin receptor
antagonist) inhibits insulin secretion in vitro. NS Arch Pharmacol 332:284-287, 1986.
138. Vigna SR, MC Thorndyke, JA Williams. Evidence for a common evolutionary origin of brain and pancreas cholecystokinin
receptors. Proc Natl Acad Sci USA 83:4355-4359, 1986.
139. Niederau C, M Niederau, JA Williams, JH Grendell. New proglumide-analogue CCK receptor antagonists: Very potent and
selective for peripheral tissues. Am J Physiol 251:G856-860, 1986.
140. Hootman SR, ME Brown, JA Williams, CD Logsdon. Regulation of muscarinic acetylcholine receptors in cultured guinea pig
pancreatic acini. Am J Physiol 251:G75-83, 1986.
141. Williams JA, KA Gryson, D McChesney. Brain CCK receptors: Species differences in regional distribution and selectivity.
Peptides 7:293-296, 1986.
142. Liddle RA, GA Green, CK Conrad, JA Williams. Proteins but not amino acids, carbohydrates of fats stimulate cholecystokinin
secretion in the rat. Am J Physiol 251:G243-248, 1986.
143. Habara Y, JA Williams, SR Hootman. Antimuscarinic effects of chloroquine in rat pancreatic acini. Biochem Biophys Res
Commun 137:664-669, 1986.
144. Susini C, A Bailey, J Szecowka, JA Williams. Characterization of covalently cross-linked pancreatic somatostatin receptors. J
Biol Chem 261:16738-16743, 1986.
+
+
145. Hootman SR, ME Brown, JA Williams. Phorbol esters and A23187 regulate Na , K pump activity in pancreatic acinar cells.
Am J Physiol 252:G499-505, 1987.
146. Logsdon CD, J Zhang, J Guthrie, SR Vigna, JA Williams. Bombesin binding and biological effects on pancreatic acinar AR42J
cells. Biochem Biophys Res Commun 144:463-468, 1987.
19
John A. Williams
147. Williams JA, DJ McChesney. Cholecystokinin induces the interaction of its receptor with a guanine nucleotide binding protein.
Regulatory Peptides 18:109-117, 1987.
148. Okabayashi Y, J Moessner, CD Logsdon, ID Goldfine, JA Williams. Insulin and other stimulants have nonparallel translational
effects on protein synthesis. Diabetes 36:1054-1060, 1987.
149. Lewis LD, JA Williams. Structural characterization of somatostatin receptor in rat anterior pituitary membranes. Endocrinology
121:486-492, 1987.
150. Logsdon CD, SF Akana, C Meyer, MF Dallman, JA Williams. Pancreatic acinar cell amylase gene expression: Selective effects
of adrenalectomy and corticosterone replacement. Endocrinology 121:1242-1250, 1987.
151. DeLisle RC, JA Williams. Zymogen granule acidity is not required for stimulated pancreatic protein secretion. Am J Physiol
253:G711-719, 1987.
152. Werlin SL, DG Colton, J Harb, E Reynolds, RG Hoffman, JA Williams. Ontogeny of secretory function and cholecystokinin
binding capacity in immature rat pancreas. Life Sci 40:2237-2245, 1987.
153. Burnham DB, H-D Söling, JA Williams. Evaluation of myosin light chain phosphorylation in isolated pancreatic acini. Am J
Physiol 254:G130-134, 1988.
154. Sung CK, SR Hootman, EL Stuenkel, C Kuriowa, JA Williams. Down-regulation of protein kinase C in guinea pig pancreatic
acini: Effects on secretion. Am J Physiol 254:G242-248, 1988.
155. Williams JA, AC Bailey, E Roach. The temperature dependence of high affinity CCK receptor binding and CCK internalization
in rat pancreatic acini. Am J Physiol 254:G513-521, 1988.
156. Burnham DB, CK Sung, P Munowitz, JA Williams. Regulation of protein phosphorylation in pancreatic acini by cyclic AMPmediated secretagogues: interaction with carbamylcholine. Biochim Biophys Acta 969:33-39, 1988.
157. Stuenkel EL, T Machen, JA Williams. pH Regulatory mechanisms in rat pancreatic ductal cells. Am J Physiol 254:G925-930,
1988.
158. De Lisle RC, R Steinberg, JA Williams. Zymogen granules of mouse parotid acinar cells are acidified in situ in an ATPdependent manner. Cell Tiss. Res. 253:267-269, 1988.
159. Williams
JA, DJ McChesney, MC Calayag, VR Lingappa, CD Logsdon Expression of receptors for cholecystokinin and other
2+
Ca mobilizing hormones in xenopus oocytes. Proc Natl Acad Sci USA 85:4939-4943, 1988.
161. Möessner J, Y Okabayashi, E Perara, CD Logsdon, VR Lingappa, JA Williams. Synthesis and secretion of rat pancreatic
proteins by xenopus laevis oocytes. Pancreas 3:499-507, 1988.
162. Putnam WS, RA Liddle, JA Williams. Inhibitory regulation of the rat exocrine pancreas by peptide YY and pancreatic
polypeptide. Am J Physiol 256:G698-703, 1989.
163. Okabayashi Y, BA Maddux, AR McDonald, CD Logsdon, JA Williams, ID Goldfine. Mechanisms of insulin induced insulinreceptor down-regulation: Decrease of receptor biosynthesis and mRNA levels. Diabetes 38:182-187, 1989.
164. Szecowka J, G Hallden, ID Goldfine, JA Williams. Purification of the pancreatic cholecystokinin receptor. Regulatory Peptides
24:215-224, 1989.
165. Stuenkel EL, Y Tsunoda, JA Williams. Secretagogue-induced calcium mobilization in single pancreatic acinar cells. Biochem
Biophys Res Commun 158:863-869, 1989.
166. Garry DJ, MG Garry, JA Williams, WC Mahoney, RL Sorenson. Effects of islet hormones on amylase secretion and
localization of somatostatin binding sites. Am J Physiol 256:G897-904, 1989.
167. Sung CK, JA Williams. Insulin stimulates a specific ribosomal protein S6 kinase in rat pancreatic acini. Diabetes 38:544-549,
1989.
168. Matozaki T, JA Williams. Multiple sources of 1,2-Diacylglycerol in isolated rat pancreatic acini stimulated by cholecystokinin:
Involvement of phosphatidylinositol bisphosphate and phosphatidylcholine hydrolysis. J Biol Chem 264:14729-14734, 1989.
169. Matozaki T, J Martinez, JA Williams. A new CCK analog differentiates two functionally distinct CCK receptors in rat and
mouse pancreatic acini. Am J Physiol 257:G594-600, 1989.
170. Pezzino V, V Papa, V Trischitta, A Brunetti, PA Goodman, MK Treutelaar, JA Williams, BA Maddux, R Vigneri, ID Goldfine.
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states. Am J Physiol 257:E451-457, 1989.
171. Smith GP, D Greenberg, JD Falasco, AA Avilion, J Gibbs, RA Liddle, JA Williams. Endogenous cholecystokinin does not
decrease food intake or gastric emptying in fasted rats. Am J Physiol 257:R1462-R1466, 1989.
20
John A. Williams
172. Tsunoda Y, EL Stuenkel, JA Williams. Oscillatory mode of calcium signaling in rat pancreatic acinar cells. Am J Physiol
258:C147-C155, 1990.
173. De Lisle RC, JH Grendell, JA Williams. Growing pancreatic acinar cells (postpancreatitis and fetal) express a ductal antigen.
Pancreas 5:381-388, 1990.
174. Dunbar Lewis LD, JA Williams. Regulation of cholecystokinin secretion by food, hormones, and neural pathways in the rat.
Am J Physiol 258:G512-518, 1990.
175. Matozaki T, B Göke, Y Tsunoda, M Rodriguez,
J Martinez, JA Williams. Two functionally distinct cholecystokinin receptors
2+
show different modes of actions on Ca mobilization and phospholipid hydrolysis in isolated rat pancreatic acini. Studies using
a new cholecystokinin analog, JMV-180. J Biol Chem 265:6247-6254, 1990.
176. Sung CK, JA Williams. Choleycstokinin stimulates a specific ribosomal S6 kinase in rat pancreatic acini. Pancreas 5:668-676,
1990.
177. Sheikh SP, JA Williams. Structural characterization of Y1 and Y2 receptors for neuropeptide Y and peptide YY by affinity
cross-linking. J Biol Chem 265:8304-8310, 1990.
+
+
178. Bastié MJ, JA+ Williams. Gastrointestinal peptides activate Na -H exchanger in AR42J cells by increasing its affinity for
intracellular H . Am J Physiol 258:G958-966, 1990.
179. Kitagawa M, JA Williams, RC De Lisle. Amylase release from streptolysin O-permeabilized pancreatic acini. Am J Physiol
259:G157-164, 1990.
2+
180. Tsunoda Y, EL Stuenkel, JA Williams. Characterization of the sustained [Ca ]i increase in stimulated pancreatic acinar cells
and its relation to amylase secretion. Am J Physiol 259:G792-801, 1990.
181. Sheikh SP, E Roach, J Fuhlendorff, JA Williams. Localization of Y 1 receptors for NPY and PYY on vascular smooth muscle
cells in rat pancreas. Am J Physiol 260:G250-G257, 1991.
182. Tsunoda Y, JA Williams, J DelValle. Secretagogue-induced Ca
Biophys Acta 1091:251-254, 1991.
2+
oscillations in isolated canine gastric chief cells. Biochim
183. Kitagawa M, JA Williams, RC De Lisle. Interactions of intracellular mediators of amylase secretion in permeabilized
pancreatic acini. Biochim Biophys Acta 1073:129-135, 1991.
184. Matozaki T, W-Y Zhu, Y Tsunoda, B Göke, JA Williams. Intracellular mediators of bombesin action on rat pancreatic acinar
cells. Am J Physiol 260:G858-864, 1991.
185. Yule DI, JA Williams. Mastoparan induces oscillations of cytosolic Ca
Commun 177:159-165, 1991.
2+
in rat pancreatic acinar cells. Biochem Biophys Res
186. Zhu W-Y, B Göke, JA Williams. Binding, internalization, and processing of bombesin by rat pancreatic acini. Am J Physiol
261:G57-64, 1991.
187. Guthrie J, JA Williams, CD Logsdon. Growth and differentiation of pancreatic acinar cells: Independent effects of
glucocorticoids on AR42J cells. Pancreas 6:506-513, 1991.
188. Sheikh SP, AP Hansen, J.A. Williams. Solubilization and affinity purification of the Y 2 receptor for neuropeptide Y and peptide
YY from rabbit kidney. J Biol Chem 266:23959-23966, 1991.
189. Matozaki T, JA Williams. Regulation of phospholipid hydrolysis in streptolysin-O-permeabilized rat pancreatic acini. Pancreas
7:59-65, 1992.
190. Göke B, JA Williams, MJ Wishart, RC De Lisle. Low molecular mass GTP-binding proteins in subcellular fractions of the
pancreas: Regulated phosphoryl G-proteins. Am J Physiol 262:C493-C500, 1992.
2+
191. DelValle J, Y Tsunoda, JA Williams, T Yamada. Regulation of [Ca ]i by secretagogue stimulation of canine gastric parietal
cells. Am J Physiol 262:C420-C426, 1992.
2+
192. Yule DI, J Williams. U73122 inhibits Ca oscillations in response to CCK and carbachol but not to JMV-180 in rat pancreatic
acinar cells. J Biol Chem 267:13830-13835, 1992.
193. Blevins Jr GT, JA Williams. ATP induces two cholecystokinin binding affinity states in permeabilized rat pancreatic acini. Am
J Physiol 263:G44-G51 1992.
2+
194. Yule D, GT Blevins Jr, ACC Wagner, JA Williams. Endothelin increases [Ca ]i in rat pancreatic acinar cells by intracellular
release but fails to increase amylase secretion. Biochim Biophys Acta 1136:175-180, 1992.
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John A. Williams
195. Wagner ACC, MJ Wishart, DI Yule, JA Williams. Effects of okadaic acid indicate a role for dephosphorylation in pancreatic
stimulus-secretion coupling. Am. J. Physiol., 263:C1172-C1180, 1992.
196. Wishart MJ, PC Andrews, R Nichols, GT Blevins Jr, CD Logsdon, JA Williams. Identification and cloning of GP-3 from rat
pancreatic acinar zymogen granules as a glycosylated membrane-associated lipase. J Biol Chem 268:10303-10311, 1993.
197. Wagner ACC, C Schaefer, JA Williams. Effects of calyculin A on amylase release in streptolysin-O permeabilized acinar cells.
Biochem Biophys Res Commun 189:1606-1612, 1993.
198. Yule DI, TE Essington, JA Williams. Pilocarpine and carbachol exhibit markedly different patterns of Ca 2+ signaling in rat
pancreatic acinar cells. Am J Physiol 264:G786-G791, 1993.
199. Yule DI, D Wu, TE Essington, JA Shayman, JA Williams. Sphingosine metabolism induces Ca
acinar cells. J Biol Chem 268:12353-12358, 1993.
2+
oscillations in rat pancreatic
200. Yule DI, M-J Tseng, JA Williams, CD Logsdon. A cloned CCK A receptor transduces multiple signals in response to full and
partial agonists. Am J Physiol 265:G999-G1004, 1993.
201. Yang J, CD Logsdon, TE Johansen, JA Williams. Human m3 muscarinic acetylcholine receptor carboxyl-terminal threonine
residues are required for agonist-induced receptor down-regulation. Mol Pharmacol 44:1158-1164, 1994.
202. Wagner ACC, MJ Wishart, SM Mulders, PM Blevins, A Lowe, PC Andrews, JA Williams. GP-3, a newly characterized
glycoprotein on the inner surface of the zymogen granule membrane, undergoes regulated secretion. J Biol Chem 269:90999104, 1994.
203. Duan R-D, ACC Wagner, DI Yule, JA Williams. Multiple inhibitory effects of genistein on stimulus-secretion coupling in rat
pancreatic acini. Am J Physiol 266:G303-G310, 1994.
2+
2+
204. Duan R-D, Y-J Guo, JA Williams. Conversion to Ca -independent form of Ca /calmodulin protein kinase II in rat pancreatic
acini. Biochem Biophys Res Commun 199:368-373, 1994.
205. Blevins Jr, GT, EMA van de Westerlo, DI Yule, JA Williams. Characterization of cholecystokininA receptor agonist activity by
a family of cholecystokininB receptor antagonists. J Pharm Exp Ther 269:911-916, 1994.
2+
206. Groblewski GE, ACC Wagner, JA Williams. Cyclosporin A inhibits Ca /calmodulin-dependent protein phosphatase and
secretion in pancreatic acinar cells. J Biol Chem 269:15111-15117, 1994.
207. Wagner ACC, MZ Strowski, JA Williams. Identification of rab5 but not rab3A in rat pancreatic zymogen granule membranes.
Biochem Biophys Res Commun 200:542-548, 1994.
208. Duan R-D, JA Williams. Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini. Am J
Physiol 267:G401-G408, 1994.
209. Yule DI, JA Williams. CCK antagonists reveal that CCK-8 and JMV-180 interact with different sites on the rat pancreatic
acinar cell CCKA receptor. Peptides 15:1045-1051, 1994.
210. Yule DI, ET Kim, JA Williams. Tyrosine kinase inhibitors attenuate "capacitative" Ca 2+ influx in rat pancreatic acinar cells.
Biochem Biophys Res Commun 202:1697-1704, 1994.
211. Wishart MJ, G Groblewski, BJ Göke, ACC Wagner, JA Williams. Secretagogue regulation of pancreatic acinar cell protein
phosphorylation shown by large-scale 2D-PAGE. Am J Physiol 267:G676-G686, 1994.
212. Blevins Jr GT, EMA van de Westerlo, JA Williams. Nucleoside diphosphate kinase associated with rat pancreatic membranes
regulates cholecystokinin receptor affinity. Am J Physiol Am J Physiol 267:G866-G874, 1994.
213. Palmer RK, DI Yule, EL McEwen, JA Williams, SK Fisher. Agonist-specific calcium signaling and phosphoinositide
hydrolysis in human SK-N-MCIXC neuroepithelioma cells. J Neurochemistry 63:2099-2107, 1994.
214. Bode HP, DI Yule, HC Fehmann, B Göke, JA Williams. Spontaneous calcium oscillations in clonal endocrine pancreatic
glucagon-secreting cells. Biochem Biophys Res Commun 205:435-440, 1994.
215. Groblewski GE, Y Wang, SA Ernst, C Kent, JA Williams. Cholecystokinin stimulates the down-regulation of
CTP:Phosphocholine cytidylyltransferase in pancreatic acinar cells. J Biol Chem 270:1437-1442, 1995.
216. Simeone DM, DI Yule, CD Logsdon, JA Williams. Ca2+ signaling through secretagogue and growth factor receptors on
pancreatic AR42J cells. Regulatory Peptides 55:197-206, 1995.
217. Wagner ACC, MZ Strowski, B. Göke, JA Williams. Molecular cloning of a new member of the RAB protein family, RAB 26,
from rat pancreas. Biochem Biophys Res Commun 207:950-956, 1995.
22
John A. Williams
218. Duan R-D, C-F Zheng, K-L Guan, JA Williams. Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat
pancreatic acini. Am J Physiol 268:G1060-G1065, 1995.
219. Van de Westerlo E, J Yang, C Logsdon, JA Williams. Down-regulation of G-proteins Gq and G11 by transfected human M3
muscarinic acetylcholine receptors in Chinese hamster ovary cells is independent of receptor down-regulation. Biochem J
310:559-563, 1995.
220. Wagner ACC, JA Williams. Calcium induces rapid changes in protein phosphorylation in permeabilized pancreatic acini.
Pancreas 11:236-240, 1995.
221. Yang J, JA Williams, DI Yule, CD Logsdon. Mutation of carboxyl-terminal threonine residues in human m3 muscarinic
acetylcholine receptor modulates the extent of sequestration and desensitization. Mol Pharmacol 48:477-485, 1995.
222. Deutsch ED, JA Williams, DI Yule. Halothane and octanol block Ca 2+ oscillations in pancreatic acini by multiple mechanisms.
Am J Physiol 269:G779-G788, 1995.
223. Wishart MJ, JM Denu, JA Williams JE Dixon. A single multation converts a novel phosphotyrosine binding domain into a
dual-specificity phosphatase. J Biol Chem 270:26782-26785, 1995.
224. Blevins GT, van de Westerlo EMA, Logsdon CD, Blevins PM, Williams JA. Nucleotides regulate the binding affinity of the
recombinant type A cholecystokinin receptor in CHO K1 cells. Regulatory Peptides 61:87-93, 1996.
225. Dabrowski A, T Grady, CD Logsdon, JA Williams. Jun kinases are rapidly activated by cholecystokinin in rat pancreas both in
vitro and in vivo. J Biol Chem 271:5686-5690, 1996.
226. Palmer RK, DK Yule, DS Shewach, JA Williams, SK Fisher. Paracrine mediation of calcium signaling in human SK-NMCIXC neuroepithelioma cells. Am J Physiol 271:C43-C53, 1996.
227. Hwang J, MJ Bragado, D Rui-Dong, JA Williams. Protein phosphatase inhibitors potentiate Ca 2+/calmodulin-dependent protein
kinase II activity in rat pancreatic acinar cells. Biochem Biophys Res Commun 225:520-524, 1996.
228. Ohnishi H, SA Ernst, N Wys, M McNiven, JA Williams. Rab3D localizes to zymogen granules in rat pancreatic acini and other
exocrine glands. Am J Physiol 271:G531-G538, 1996.
229. Yule DI, E Stuenkel, JA Williams. Intercellular calcium waves in rat pancreatic acini: mechanism of transmission. Am J
Physiol 271:C1285-C1294, 1996.
230. Dabrowski A, J VanderKuur, C Carter-Su, JA Williams. Cholecystokinin stimulates formation of Shc-GRb2 complex in rat
pancreatic acinar cells through a protein kinase C dependent mechanism. J Biol Chem 271:27125-27129, 1996.
231. Groblewski GE, MJ Wishart, M Yoshida, JA. Williams. Purification and identification of a 28-kDa calcium-regulated heatstable protein. J Biol Chem 271:31502-31507, 1996.
232. Grady T, A Dabrowski, JA Williams, CD Logsdon. Stress-activated protein kinase activation is the earliest direct correlate to
the induction of secretagogue-induced pancreatitis in rats. Biochem Biophys Res Commun 227:1-7, 1996.
233. Bragado MJ, A Dabrowski, GE Groblewski, JA Williams. CCK activates p90rsk in rat pancreatic acini through protein kinase C.
Am J Physiol 272:G401-G407, 1997.
234. Groblewski GE, T Grady, N Mehta, H Lambert, CD Logsdon, J Landry, JA Williams. Cholecystokinin stimulates heat shock
protein 27 phosphorylation in rat pancreas both in vivo and in vitro. Gastroenterology 112:1354-1361, 1997.
235. Ohnishi H, SA Ernst, DI Yule, CW Baker, JA Williams. Heterotrimeric G-protein Gq/11 localized on pancreatic zymogen
granules is involved in calcium-regulated amylase secretion. J Biol Chem 272:16056-16061, 1997.
236. Bragado MJ, GE Groblewski, JA Williams. P70 s6k is activated by CCK in rat pancreatic acini. Am J Physiol 273:C101-C109,
1997.
237. Dabrowski A, KM Detjen, CD Logsdon, JA Williams. Stimulation of both CCK-A and CCK-B receptors activates MAP
kinases in AR42J and receptor-transfected CHO cells. Digestion 58:361-367, 1997.
238. Detjen K, D Yule, M-J Tseng, JA Williams, CD Logsdon. CCKB and CCKA receptors couple similarly to second messenger
pathways and inhibit Chinese hamster ovary but stimulated Swiss 3T3 cell growth. Am J Physiol 273:C1449-C1457, 1997.
239. Dabrowski A, GE Groblewski, C Schäfer, K-L Guan, JA Williams. Cholecystokinin and EGF activate a MAPK cascade by
different mechanisms in rat pancreatic acinar cells. Am J Physiol 273:C1472-C1479, 1997.
240. Ohnishi H, LC Samuelson, DI Yule, SA Ernst, JA Williams. Overexpression of Rab3D enhances regulated amylase
secretion from pancreatic acini of transgenic mice. J Clin Invest 100:3044-3052, 1997.
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John A. Williams
241. Bragado MJ, GE Groblewski, JA Williams. Regulation of protein synthesis by cholecystokinin in rat pancreatic acini
involves PHAS-1 and the p70 S6 kinase pathway. Gastroenterology 115:733-742, 1998.
242. Groblewski GE, M Yoshida, MJ Bragado, SA Ernst, J Leykam, JA Williams. Purification and characterization of a novel
physiological substrate for calcineurin in mammalian cells. J Biol Chem 273:22738-22744, 1998.
243. Schäfer C, SE Ross, MJ Bragado, GE Groblewski, SA Ernst, JA Williams. A role for the p38 mitogen-activated protein
kinase/Hsp27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini. J Biol Chem
273:24173-24180, 1998.
244. Yule DI, CW Baker, JA Williams. Calcium signaling in rat pancreatic acinar cells: a role for Gq, G11 and G14. Am J
Physiol 276:G271-G279, 1999.
245. Groblewski GE, M Yoshida, H Yao, JA Williams, SA Ernst. Immunolocalization of CRHSP-28 in exocrine digestive glands
and gastrointestinal tissues of the rat. Am J Physiol 276:G219-G226, 1999.
246. Schäfer C, P Clapp, MJ Welsh, R Benndorf, JA Williams. Hsp27 expression regulates CCK-induced changes of the actin
cytoskeleton in CHO-CCKA cells. Am J Physiol 277:C1032-C1043, 1999.
247. Schäfer C, JA Williams. Stress kinases and heat shock proteins in the pancreas: possible roles in normal function and
disease. J Gastroenterology 35:1-9, 2000.
248. Bragado MJ, M Tashiro, JA Williams. Regulation of the initiation of pancreatic digestive enzyme protein synthesis by
cholecystokinin in rat pancreas in vivo. Gastroenterology 119:1731-1739, 2000.
249. Tashiro M, C Schäfer, H Yao, SA Ernst, JA Williams. Arginine-induced acute pancreatitis alters the actin cytoskeleton and
increases heat shock protein expression in rat pancreatic acinar cells. Gut, 49:251-262, 2001.
250. Sans MD. Kimball SR, Williams JA. Effect of CCK and intracellular calcium to regulate eIF2B and protein synthesis in rat
pancreatic acinar cells. Am J Physiol 282:G267-G276, 2002.
251. Chen X, JAS Edwards, J, CD Logsdon, SA Ernst, JA Williams. Dominant negative Rab3D inhibits amylase release from
mouse pancreatic acini. J Biol Chem 277:18002-18009, 2002.
252. Tashiro M, SA Ernst, J Edwards, JA Williams. Hyperthermia induces multiple pancreatic heat shock proteins and protects
against subsequent arginine-induced acute pancreatitis in rats. Digestion 65:118-126, 2002.
253. Sans MD, MJ DiMagno, LG D’Alecy, JA Williams. Caerulein-induced acute pancreatitis inhibits protein synthesis through
effects on eIF2B and eIF4F. Am J Physiol 285:G517-G528, 2003.
254. LePage S, Y Bi, JA Williams. The CCK-A receptor activates RhoA through G12/13 in NIH 3T3 cells. Am J Physiol
285:C1197-C1206, 2003.
255. Chen X, SA Ernst, JA Williams. Dominant negative Rab3D mutants reduce GTP-bound endogenous Rab3D in pancreatic
acini. J Biol. Chem 278:50053-50066, 2003.
256. DiMagno MJ, Y Hao, Y Tsunoda, JA Williams, C Owyang. Secretagogue-stimulated pancreatic secretion is differently
regulated by constitutive nitric oxide synthase isoforms in mice. Am J Physiol GI&L 286:G428-G436, 2004.
257. Tashiro M, LC Samuelson, RA Liddle, JA Williams. Calcineurin mediates pancreatic growth in protease inhibitor-treated
mice. Am J Physiol GI&L 286:G784-G790, 2004.
258. DiMagno MJ, JA Williams, Y Hao, SA Ernst, C Owyang. Endothelial nitric oxide synthase is protective in the initiation of
caerulein-induced acute pancreatitis in mice. Am J Physiol 287:G80-G87, 2004.
259. Sans MD, JA Williams. Calcineurin is required for translational control of protein synthesis in rat pancreatic acini. Am J
Physiol 287:C310-C319, 2004.
260. Sans MD, S-H Lee, LG D’Alecy, JA Williams. Feeding activates protein synthesis in mouse pancreas at the translational
level without increase in mRNA. Am J Physiol 287:G667-G675, 2004.
261. Sans MD, Q Xie, JA Williams. Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini.
Biochem Biophys Res Commun 319:144-151, 2004.
262. Kubisch C, DiMagno MJ, Tietz AB, Welsh MJ, Ernst SA, Brandt-Nedelev B, Diebold J, Wagner ACC, Göke B, Williams
JA, Schäfer C. Overexpression of heat shock protein Hsp27 protects against caerulein-induced pancreatitis.
Gastroenterology 127:275-286, 2004. PMID: 15236192
263. Li C, X Chen, JA Williams. Regulation of CCK-induced amylase release by protein kinase C delta in rat pancreatic acinar
cells. Am J Physiol 287:G764-G771, 2004.
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John A. Williams
264. Chen X, C Li, T Izumi, SA Ernst, PC Andrews, JA Williams. Rab27b localizes to zymogen granules and regulates
pancreatic acinar exocytosis. Biochem Biophys Res Comm 323:1156-1161, 2004.
265. Bi Y, JA Williams. A role for Rho and Rac in secretagogue induced amylase release by pancreatic acini. Am J Physiol
289:C22-C32, 2005.
266. Bi Y, S Le Page, JA Williams. Rho and Rac promote acinar morphological changes, actin reorganization and amylase
secretion. Am J Physiol 289:G561-G570, 2005.
267. Kubisch, C.H., Sans, M.D., Ernst, S.A., Williams J.A., Logsdon, C.D. Early activation of endoplasmic reticulum stress is
associated with arginine induced acute pancreatitis. Am J Physiol 291:G238-G245. 2006.
268. Chen X, AK Walker, JR Strahler, ES Simon, SL Tomanicek-Volk, BB Nelson, MC Hurley, SA Ernst, JA Williams, PC
Andrews. Organellar proteomics: Analysis of pancreatic zymogen granule membranes. Mol & Cell Proteomics 5:306-312,
2006.
269. Tashiro M, A Dabrowski, L Guo, MD Sans, JA Williams. Calcineurin dependent and independent signal transduction
pathways activated as part of pancreatic growth. Pancreas 32:314-320, 2006.
270. Crozier SJ, MD Sans, L Guo, LG D’Alecy JA Williams. Activation of the mTOR signaling pathway is required for pancreatic
growth in protease inhibitor-fed mice. J Physiol 573:775-786, 2006
271. Sans MD, M Tashiro, N Vogel, SR Kimball, LG D’Alecy, JA Williams. Leucine activates pancreatic translational
machinery through mTOR independent of CCK and insulin. J Nutrition 136:1792-1799, 2006.
272. Guo L, MD Sans, GT Gurda, SH Lee, SA Ernst, JA Williams. Induction of early response genes in trypsin inhibitor-induced
pancreatic growth. Am J Physiol, 292:G667-G677, 2007.
273. Gurda GT, L Guo, SH Lee, JD Molkentin, JA Williams. Cholecystokinin (CCK) activates pancreatic calcineurin-NFAT
signaling in vitro and in vivo. Mol Biol of the Cell, 19:198-206, 2008. PMCID: 2174201
274. Crozier SJ, MD Sans, CH Lang, LG D’Alecy, SA Ernst, JA Williams. CCK-induced pancreatic growth is not limited by
mitogenic capacity in mice. Am J Physiol, 294:G1148-G1157, 2008.
275. Sabbatini ME, X Chen, SA Ernst, JA Williams. Rap activation plays a regulatory role in pancreatic amylase secretion. J Biol
Chem, 283:23884-23894, 2008. PMCID: 2527106
276. Chen X, PJ Ulintz, ES Simon, JA Williams and PC Andrews. Global topology analysis of pancreatic zymogen granule
membrane proteins. Mol Cell Proteomics, 7:2323-36, 2008 PMCID: 2596344
277. Crozier SJ, LG D’Alecy, SA Ernst, LE Ginsberg, and JA Williams. Molecular mechanisms of pancreatic dysfunction
induced by protein malnutrition. Gastroenterology, 137:1093-1101, 2009. PMCID: 2739082
278. Lee SH, MJ Wishart, JA Williams. Identification of calcineurin regulated phosphorylation sites on CRHSP-24. Biochem
Biophys Res Commun 385:413-417, 2009. PMCID: 2740617
279. Chen X, Sans MD, Strahler JR, Karnovsky A, Ernst SA, Michailidis G, Andrews PC, Williams JA. Quantitative organellar
proteomics analysis of rough endoplasmic reticulum from normal and acute pancreatitis rat pancreas. J. Proteome Res.
9:885-896, 2010. PMCID: PMC2818835
280. Sabbatini ME, Y Bi, B Ji, S Ernst, and JA Williams. CCK activates RhoA and Rac1 differentially through Gα13 and Gαq in
mouse pancreatic acini. Am J Physiol: Cell Physiol. 298: C592-601,2010. PMCID: PMC2838570
281. Gurda GT, Crozier SJ, Ji B, Ernst SA, Logsdon CD, Rothermel BA, and JA Williams. Regulator of calcineurin 1 (Rcan1)
controls growth plasticity of adult pancreas. Gastroenterology, 139:609-619, 2010. PMCID: PMC2929702
282. Crozier SJ, Sans MD, Wang JY, Lentz SI, Ernst SA, Williams JA. CCK-independent mTORC1 activation during dietary
protein-induced exocrine pancreatic growth. Am J Physiol:GI & L Physiology, 299:G1154-G1163, 2010. PMCID:
PMC2993171
283. Sans MD, Sabbatini ME, Ernst SA, D’Alecy LG, Nishijima I, Williams JA. Secretin is not necessary for exocrine
pancreatic development and growth in mice. Am J Physiol: GI & L Physiology, 301:G791-G798, 2011. PMCID:
PMC3220326
284. Gurda GT, Wang JY, Guo L, Ernst SA, Williams JA. Profiling CCK-mediated pancreatic growth: the dynamic genetic
program and the role of STATs as potential regulators. Physiological Genomics, 44:14-24,2012. PMCID: PMC3289124 .
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John A. Williams
285. Guo L, Sans MD, Hou Y, Ernst SA, Williams JA. C-Jun/AP1 is required for CCK induced pancreatic acinar cell
dedifferentiation and DNA synthesis in vitro. Am J Physiol: GI & L Physiology, 302:G1381-G1396, 2012. PMCID:
PMC337809
286. Sabbatini ME, Williams JA. Cholecystokinin-mediated RhoGDI Phosphorylation via PKCα promotes both RhoA and Rac1
signaling. PLoS One, Submitted for publication.
287. Hou Y, Chen X, Ernst SA, Williams. Identification of EPI64B as GTPase-activating protein in pancreatic acinar cells. J
Biol Chem. Submitted for publication.
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John A. Williams
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1.
Withrow CD, T Elsmore, JA Williams, DM Woodbury. Hydrogen ion distribution and regulation in various rat tissues. In: Ion
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Williams J.A. Cholecystokinin: A hormone and a neurotransmitter. Biomedical Research 3:107-121, 1982.
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Williams JA, SR Vigna, C Sakamoto, ID Goldfine. Brain cholecystokinin receptors: Binding characteristics, covalent
crosslinking, and evolutionary aspects. Ann N Acad Sci 448:220-230, 1985.
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Williams JA, ID Goldfine. The insulin-pancreatic acinar axis. Diabetes 34:980-996, 1985.
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Logsdon CD, J Moessner, ID Goldfine, JA Williams. Regulation of pancreatic acinar carcinoma AR42J cells in vitro: Effects of
glucocorticoids, insulin and cholecystokinin. In: Regulatory Peptides in Digestive, Nervous and Endocrine Systems. INSERM
Symposium No. 25, MJM Lewin, S Boufils (Eds). Elsevier, Amsterdam, pp. 421-429, 1985.
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Mossner J, CD Logsdon, ID Goldfine, JA Williams. Regulation der azinuszellrezeptoren durch peptidhormone. Zeit
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Williams JA, SR Hootman. Stimulus-secretion coupling in pancreatic acinar cells. In: The Exocrine Pancreas: Basic and
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Williams JA, ID Goldfine. Endocrine-exocrine relationships: The insulin-acinar relationship. In: The Exocrine Pancreas: Basic
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27.
DeLisle RC, JA Williams. Regulation of membrane fusion in secretory exocytosis. Ann Rev. Physiol 48:225-238, 1986.
28.
Korenbrot JI, J.E Brown, DL Ochs, JA Williams, DL Miller. The use of tetracarboxylate fluorescent indicators in the
measurement and control of intracellular free calcium ions. In: Optical Methods in Cell Physiology. P DeWeer, BM Salzberg
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Williams JA. Mechanisms in hormone secretion action and response. In: Basic and Clinical Endocrinology. FS Greenspan, PH
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Williams JA. Workshop report: Gut-islet-pancreatic acinar interaction. Pancreas 2:240-241, 1987.
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Williams JA. Role of receptors in mediating trophic stimuli in the pancreas. Gut 28:S1, 45-49, 1987.
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Niederau C, RA Liddle, JA Williams, JH Grendell. Pancreatic growth: interaction of exogenous cholecystokinin, a protease
inhibitor, and a cholecystokinin receptor antagonist in mice. Gut 28 (supp) 63-69, 1987.
34.
Williams JA, C Susini. Structural analysis of somatostatin receptors in somatostatin: Basic and clinical status. S Reichlin (Ed),
New York, Plenum, 1987, pp 103-109.
35.
Sung C.K., JA Williams. The role of calcium in pancreatic acinar cell secretion. Mineral and Electrolyte Metabolism 14:71-77,
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36.
Williams JA, CK Sung, EL Stuenkel, SR Hootman. Role of intracellular calcium and protein kinase C in pancreatic acinar cell
secretion. In: Molecular Mechanisms of Secretion, N Thorn and O Peterson (Eds), Munksgaard, Copenhagen, pp 297-308,
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Williams JA. Regulatory functions of GI peptides. Reg Peptide Lett 1:6-9, 1988.
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Williams JA, DB Burnham, SR Hootman. Cellular regulation of pancreatic secretion. In: Handbook of Physiology, Section
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39.
Dunbar Lewis L, JA Williams. Cholecystokinin: A key integrator of nutrient assimilation, NIPS 5:163-167, 1990.
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Williams JA, G Hallden, D McChesney, J Szecowka, CD Logsdon, ID Goldfine: The cholecystokinin and gastrin receptors.
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Williams JA. Physiological evidence for islet-acinar interaction. Reg Peptide Lett 2:8-11, 1990.
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Logsdon CD, JA Williams, E Stuenkel, S Rosewicz. Expression of Ca2+ mobilizing receptors in Xenopus oocytes: A tool for
receptor characterizations. Digestion 46 (Suppl 2):105-111, 1990.
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Rushakoff RJ, RA Liddle, JA Williams, ID Goldfine. The role of cholecystokinin and other gut peptides on regulation of
postprandial glucose and insulin levels. In: Insulin, P Cuatrecasas, S Jacobs (Eds), Berlin, Springer-Verlag, pp 125-142, 1990.
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Sheikh S, JA Williams. Structural characterization of Y1 and Y2 receptors for neuropeptide Y and peptide YY. Ann NY Acad
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Owyang C, JA, Williams. Pancreatic Secretion. In: Textbook of Gastroenterology. T Yamada, DH Alpers, C Owyang, DW
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46.
Argent BE, S Githens, S Kalser, DS Longnecker, R Metzgar, JA Williams. Conference Report: The pancreatic duct cell.
Pancreas 7:403-419, 1992.
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Williams, JA, DC Dawson: Cell structure and function. In: Surgery, Scientific Principles and Practice, LJ Greenfield, MW
Mulholland, KT Oldham, GB Zelenock (Eds), Philadelphia, JB Lippencott Co, pp 3-38, 1992; Second Edition, pp 3-39, 1997.
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Wagner ACC, JA Williams. Low molecular weight GTP-binding proteins: Molecular switches regulating diverse cellular
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Yule DI, JA. Williams: Stimulus-secretion coupling in the pancreatic acinus. In: Physiology of the Gastrointestinal Tract 3rd
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Wagner ACC, JA Williams. Pancreatic zymogen granule membrane proteins: Molecular details begin to emerge. Digestion
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Williams JA. Signal transduction and intracellular signaling in pancreatic acinar cells. Curr Opinion in Gastroenterology
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Williams JA. The training of physiologists for the 21st century. The Physiologist 38:189-191. 1995.
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Palmer RK, DI Yule, EL McEwen, JA Williams, SK Fisher. Intra- and intercellular calcium signaling in human
neuroepithelioma cells. J Lipid Mediators and Cell Signaling. J Lipid Mediators Cell Signaling 14:169-174, 1996.
56
Goldfine ID, CK Sung, JA Williams. Mechanisms of Hormone Action. Bloodworth’s Endocrine Pathology, 3rd Edition, J
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57.
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Williams JA. Pancreatic acinar cell intracellular signaling mechanisms. Curr Opinion in Gastroenterology 13:369-374, 1997.
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Williams JA. Systems Biology as Applied to Gastroenterology. AGA Perspectives 3:7, 2007.
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Sans MD, Crozier SJ, Williams JA. Regulation of pancreatic protein synthesis and growth. Chapter 11 In: The Pancreas: A
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Williams JA. Receptor-mediated signal transduction pathways and the regulation of pancreatic acinar cell function. Curr
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Williams JA, Chen X, Bi Y, and Lim JW. Cellular mechanisms of pancreatic digestive enzyme secretion. In Future
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Williams JA, Chen X, Sabbatini ME. Small G proteins as key regulators of pancreatic digestive enzyme secretion. Am J
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Williams JA and DiMagno MJ. Can too much acid sour your pancreas? Gastroenterology 137:779-782, 2009, Editorial
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Chen X, and Williams JA. (2010). Purification of Pancreatic Zymogen Granules Using Percoll Gradients. The Pancreapedia:
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Hou Y, Chen X, Williams JA. (2010). Rab27. The Pancreapedia: Exocrine Pancreas Knowledge Base, DOI:
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Williams, JA. (2010). Isolation of rodent pancreatic acinar cells and acini by collagenase digestion. The Pancreapedia: Exocrine
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Williams JA. (2010). Rab6. The Pancreapedia: Exocrine Pancreas Knowledge Base, DOI: 10.3998/panc.2010.9
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Williams JA. (2010). Rab1. The Pancreapedia: Exocrine Pancreas Knowledge Base, DOI: 10.3998/panc.2010.8
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Chen X, Karnovsky A, Sans MD, Andrews PC, Williams JA. Molecular Characterization of the Endoplasmic Reticulum:
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Williams JA. (2011). Galpha s. The Pancreapedia: Exocrine Pancreas Knowledge Base, DOI: 10.3998/panc.2011.19
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Williams JA. (2011). Galpha12/13. The Pancreapedia: Exocrine Pancreas Knowledge Base, DOI: 10.3998/panc.2011.7
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Sabbatini ME and Williams JA. (2012) EPAC. The Pancreapedia: Exocrine Pancreas Knowledge Base, DOI:
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Williams JA. (2012). CRHSP-24. The Pancreapedia: Exocrine Pancreas Knowledge Base, DOI: 10.3998/panc.2012.7
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Williams JA, Yule DI. Stimulus-secretion coupling in pancreatic acinar cells. Chapter 50 In: Physiology of the Gastrointestinal
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Sans Gili, MD, Williams, JA. (2012). Insulin Receptor. The Pancreapedia: Exocrine Pancreas Knowledge Base, DOI:
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Williams JA (2013). The Nobel Pancreas: A Historical Perspective. Gastroenterology. In Press.
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Williams JA (2013). Proteomics as a systems approach to pancreatitis. Pancreas. In Press.
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