謝俊民醫師之個人著作 (更新至 2015/04) 1. Jiunn-Min Shieh, Yen-An Tang, Tsung-Han Yang, Chih-Yi Chen, Han-Shui Hsu, Yi-Hung Carol Tan, Ravi Salgia, Yi-Ching Wang. Lack of Association of C-Met-N375S Sequence Variant with Lung Cancer Susceptibility and Prognosis. Int.J.Med.Sci.2013; 10(8):988-994(I.F:2.24, ranking 35/153=23% on medicine, general & internal) 2. Jiunn-Min Shieh, Yung-Chan Chen, Yin-Chao Lin, Jia-Ni Lin, Wei-Chih Chen,Yang-Yuan Chen, Chi-Tang Ho, Tzong-Der Way. Demethoxycurcumin Inhibits Energy Metabolic and Oncogenic Signaling Pathways through AMPK Activation in Triple-Negative Breast Cancer Cells. J.Agric.Food Chem.2013, 61, 6366-6375. (I.F:2.82, ranking 3/57=5.3% on Agriculture, multidisciplinar) 3. Shian-Chih Ko*, Chi-Ruei Huang*, Jiunn-Min Shieh, Jhen-Hong Yang, Wen-Chang Chang, Ben-Kuen Chen. Epidermal Growth Factor Protects Squamous Cell Carcinoma against Cisplatin-Induced Cytotoxicity through Increased Interleukin-1β Expression. PLOS one, 2013,8(2): e55795(I.F:4.09, ranking 12/84=14% on Biology) 4. Jia-Yang Chen, Yen-An Tang, en-Shan Li, Yu-Ching Chiou, Jiunn-Min Shieh*, Yi-Ching Wang*. A Synthetic Podopyllotoxin Devirative Exerts Ant-Cancer Effects by Inducing Mitotic Arrest and Pro-Apoptotic ER Stress in Lung Cancer Preclinical Models. PLoS one, 2013, April: e62082. (Corresponding author) (I.F:4.09, ranking 12/84=14% on Biology) 5. Huey-Ming Lo, Jiunn-Min Shieh, Chih-Li Chen, Chih-Jen Tsou, Wen-Bin Wu. Vascular Endothelial Growth Factor Induces CXCL1 Chemokine Release via JNK and PI-3K-Dependent Pathways in Human Lung Carcinoma Epithelial Cells. Int.J. Mol.Sci.2013,14, 10090-10106. 6. Jiunn-Min Shieh, T.-T. Wei, Y.-A. Tang, S.-M. Huang, W.-L. Wen, M.-Y. Chen, S.B. Salunke, C.-T. Chen, C.-S. Chen, Y-C Wang. Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models. PLoS one, 2012,7(1): e30240. (I.F:4.09, ranking 12/84=14% on Biology) 7. Jiunn-Min Shieh, Tzu-Tang Wei, Yen-An Tang, Sin-Ming Huang, Wei-Ling Wen, Mei-Yu Chen, Hung, Chi Cheng ,- Santosh B. Salunke, Ching-Shih Chen, Pinpin Lin, Chien-Tien Chen, Yi-Ching Wang. Mitochondrial Apoptosis and FAK Signaling Disruption by a Novel Histone Deacetylase Inhibitor, HTPB, in Antitumor and Antimetastatic Mouse Models. PLoS one, 2012;7,issue 1,e30240. 8. Hung-Jen Tang, Yin-Ching Chung, Wen-Chien Kp, Chi-Chung Chen, Jiunn-Min Shieh, Chung-Hua Chen, Nan-Yao Lee, Shyh-Ren Chiang. Comparative evaluation of intratracheal colistimethate sodium, imipenem, and meropenem in BALB/c mice with carbapenem-resistant Acinetobacter baumannii pneumonia. Int J Infect Dis, 2012; 1,16(1):e34-e40. 9. Jiunn-Min Shieh, Tsan-Hwang Cheng, Ming-Der Shi, Pei-Fen WU, Yi Chen, Shian-Chin Ko, Yuan-Wei Shih. α-Tomatine Suppresses Invasion and Migration of Human Non-Small Cell Lung Cancer NCI-H460 Cells Through Inactivation FAK/PI3K/Akt Signaling Pathway and Reducing Binding Activity of NF-κB. Cell Biochem Biophys, 2011; 60,297-310. 10. Nai-Ding Liao, Jiunn-Min Shieh, Wen-Ying Lee.Diagnostic Value of Metabolic Phenotypes in Malignant Pleural Effusions: expression of GLUT1 and CAIX by immunocytochemistry. Cancer Cytotopatho 2011,published online (I.F:2.77, ranking 21/76=28% on pathology) 11. Jiunn-Min Shieh, Tur-Fu Hung, Chi-Feng Hung, Kuan-Hsien Chou, Yih-Jeng Tsai and Wen-Bin Wu. Activation of c-Jun N-terminal kinase is essential for mitochondrial membrane potential change and apoptosis induced by doxycycline in melanoma cells. British Journal of Pharacology, 2010; 160:1171-1181. 12. Cheng-Ta Yang, Jen-Yu Hung,Chun-Liang lai, Hsin-Chia Hung, Yung-Fa Lai, Meng-Chih Lin, Jiunn-Min Shieh, Ming-Shyan Huang. Gefitinib as First- Line Therapy for Advanced or Metastatic NSCLC Patients in Southern Taiwan. Kaohsiung J Med Sci. 2010, 26:1-7. 13. Pin-Liang Chen, *Jiunn-Min Shieh, Shiann-Chin Ko. Two Synchronous Primary Lung Cancers: A case Report. Thorac Med 2010; 25: 85-90. 14. Jiunn-Min Shieh, Hung-Tsung Wu, Kai-Chun Cheng, Juei-Tang Cheng. Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCζ-Akt-GSK3β pathway in hepatic cells. J. Pineal Res. 2009; 47:339-344. 15. Jiunn-Min Shieh, Tai-An Chiang, Wen-Teng Chang, Chang-Hung Chao, Yi-Chieh Lee, Guan-YuHung, You-Xin Shih, Yuan-Wei Shih. Plumbagin inhibits TPA-induced MMP-2 and u-PA expressions by reducing binding activitis of NF-κB and AP-1 via ERK signaling pathway in A549 human lung cancer cells. Mol Cell Biochem. 2009; 335,181-193. 16. Yuan-Wei Shih, Jiunn-Min Shieh, Pei-FenWu, Yi-Chieh Lee, Yi-Zhi Chen, Tai-An Chiang.α-Tomatine inactivates PI3K/Akt and ERK signaling pathways in human lung adenocarcinoma A549 cells: Effect on metastasis. Food and Chemical Toxicology. 47(2009) 1985-1995.(sci) 17. Ching-Yih Lin, Shih-Bin Su, Chih-Ching Chang, Tsung-Ming Lee, Jiunn-Min Shieh, How-Ran Guo. The Association Between Chlamydia Pneumoniae and Metabolic Syndrome in Taiwanese Adults. Southern Medical Journal.2009; 102(12) 18. Chi-Feng Hung, Tur-Fu Huang, Bing-Huei Chen, Jiunn-Min Shieh, Pi-Hui Wu and Wen-Bin Wu. Lycopene Inhibits TNF-alfa-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion. European Journal of Pharmacology :volume 586, issues 1-3, 31 May 2008, P275-282. 19. Hsin-Kai Huang, Chih-Hsiung Chen, Shian-Chih Ko, Kuo-Chen Cheng, Jiunn-Min Shieh, Kuo-Hwa Chaing. Anterior Mediastinal Type B3 Invasive Thymoma with Multiple Intrapulmonary Metastasses: A Case Report. Thorax Med 2008; 23: 355-361. 20. Chih-Hsiung Chen, Kun-Ming Chung, Jiunn-Min Shieh, Shian-Chin Ko,Hsiu-Nien Shen Kuo-Chen Cheng. Hemophagocytic Syndrome Associated with Diffuse Large-B-Cell Lymphoma: A case Report. Thorac Med 2008; 23: 55-60. 21. Su, Cheng-Chuan, Shieh Jiunn-Min, Li-Chien-Feng.Endobronchial metastatic breast carcinoma clinically, histologically, histologically and cytologically mimicking pulmonary small cell carcinoma. Pathology: volume 39, Number 2, April 2007, PP. 269-271 (3). 22. Shian-Chin Ko, Jian-Fong Li, Jiunn-Min Shieh. Mycobacterium avium complex(MAC) Lung Abscess Successful Treated with Traditional Antituberculosis Therapy. Thorac Med 2007; 22( 6 suppl): 87. 23. Shian-Chin Ko, Yu-Feng Tian, Jiunn-Min Shieh. Drug Interaction between Rifampin and Cycloosporin in a Renal Transplant Recipient with Pulmonary Tuberculosis. Thorac Med 2007; 22( 6 suppl): 86. 24. Chih-Hsiung Chen, Kuo-Hwa Chiang, Shian-Chin Ko, Shyh-Ren Chiang, Kuo-Chen Cheng, Jiunn-Min Shieh. Anterior Mediastinal Type B3 Invasive Thymoma with Multiple Intrapulmonary Metastases. Thorac Med 2007; 22( 6 suppl): 71 25. Chih-Hsiung Chen, Tzu-Chieh Weng, Lien-Hui Hsu, Wei-Neng Lin Shyh-Ren Chiang, Jiunn-Min Shieh. Acute Pulmonary Embolism and Occult lUng Adenocarcinoma : A Case Report of Trousseau’s Syndrome. Thorax Med 2007; 22:243-248. 26. Chih-Hsiung Chen, Jiunn-Min Shieh, Lien-Hui Hsu, Hsiu-Nien Shen Kuo-Chen Cheng, Shian-Chih Ko. Acute Respiratory Distress Syndrome Causes by Mycoplasma Pneumonia Infection: A case Report. Thorax Med 2007; 22:215-221. 27. Wei-Neng Lin, Shian-Chin Ko, Chih-Hsiung, His-Hsing Yanf, Kuo-Chen Cheng, *Jiunn-Min Shieh. Acute Pulmonary Edema Following Transjugular Intrahepatic Portosystemic Stent Shunt Creation in A Cirrhotic Patient: A Case Report. Thorac Med 2007; 22:259-264. (Corresponding author) 28. Shian-Chin Ko, Mei-Chun Chou, Jiunn-Min Shieh. Acute Lung Injury Induced by Illegal Use of Ketamine Inhalation. Thorac Med 2006; 21( 6 suppl):152. 29. Shian-Chin Ko, Mei-Chun Chou, Jiunn-Min Shieh. Acute Lung Injury Induced by Illegal Use of Ketamine Inhalation. Thorac Med 2006; 21( 6 suppl):152 30. Shian-Chin Ko, Mei-Chun Chou, Jiunn-Min Shieh. Interlobar Pulmonary Sequestration in an Elderly Woman Incidentally Found by Three-Dimensional Multi-dectector Computerized Tomography ( 3D MDCT) Angiography. Thorac Med 2006; 21( 6 suppl): 151 31. Chih-Hsiung Chen, Lien-Hui Hsu,Shian-Chin Ko, Wei-Neng Lin, Jiunn-Min Shieh. Pleural-Based Pulmonary Arteriovenous Malformation: High Risk for Ultrasound-Guided Needle Biopsy. Thorac Med 2006; 21( 6 suppl): 104 32. Shian-Chin Ko, Jiunn-Min Shieh. A Rare Case of Ethambutol-induced Toxic Epidermal Necrolysis ( TEN) in a Patient with Open Tuberculosis and Diabetic Neuropathy. Thorac Med 2006; 21( 6 suppl): 163 33. Chih-Hsiung Chen, Jiunn-Min Shieh. Lien-Hui Hsu, Kuo-Chen Cheng, Shian-Chin Ko, Acute Respiratory Distress Syndrome Associated with Mycoplasma Pneumoniae Infection: ACase Report. Thorac Med 2006; 21( 6 suppl): 164 34. Gang-Yu Shen, Kuo-Hwa Chiang, Yao Fong, Jiunn-Min Shieh. Symptomatic Mediastinal Bronchogenic Cyst Mimicking Esophageal lesion in a Patient with Chronic cough-A case Report and Literature Review. Thorac Med 2006; 21: 362-368. 35. Ming-Tai Wu, Wen-Liang Yu, Jiunn-Min Shieh, Kuo Chen Cheng. Isolated Cryptococcal Pleural Involvement in a Patient With Renal Tuberculosis. Thorac Med 2006; 21: 208-285 36. Jiunn-Min Shieh, Kue-Lin, Zenth, Sia-Lin Din, et al. The Five Years’ Experences of Respiratory Care Center in Southern Taiwan. Thorac Med 2005; 20( 6 suppl): 79 37. Kuo-Hwa Chiang, Gang-Yu Shen, Yao Fong, Jiunn-Min Shieh. Mediastinal Bronchogenic Cyst Presenting as Esophageal Lesion-A Case Report and Review of the literature. Thorac Med 2005; 20( 6 suppl): 109 38. Lien-Hui Hsu, Shian-ChinKo, Kau-Chen Cheng,Yao Fong, Jinn-Ming Chang, Ching-Nan Lin, Jiunn-Min, Shieh. Coexistence of Carcinoid Tumor and Adenocarcinoma within the Esophageal Diverticulum Complicated with Empyema Thoracis—A case report. Thorac Med 2005; 20: 463-470.(Corresponding author ) 39. En-Chung Cheng, Yao-Fong, Kuo-Chen Cheng, Shih-Sung Chung, Jiunn-Min Shieh. A Rare Case of Malignant Gastrointestinal Stromal Tumor of the Esophagus in a Patient with Chronic Cough. Thorac Med 2005; 20: 306-312. (Corresponding author) 40. Chin-Ming Chen, Mei-Yi Sung, Kuo-Chen Cheng , Jiunn-Min Shieh. The Relationship between Body Mass Index and Prognosis in a Respiratory Care Center. J Emerg Crit Care Med. Vol.16, No.1, 2005; 9-17. (Corresponding author) 41. Sheng-Chin Liao,Yung-Chih Cheng,Yo-Ching Wang, Chiung-Wen Wang, San-Ming Yang, Chun-Keung Yu, Chi-Chang Shieh, Kuo-Chen Cheng, Meng-Feng Lee, Shyh-Ren Chiang, Jiunn-Min Shieh, and Ming-Shi Chang . IL-19 Induced Th2 Cytokines and Was Up-regulated in Asthma patients. The Journal of Immunology, 2004, 173:6712-6718(sci) 42. Yi-Chieh Yang, Yen-An Tang, Jiunn-Min Shieh, Ruo-Kai Lin, Han-Shui Hsu, Yi-Ching Wang. DNMT3B Overexpression by deregulation of FOXO3a-Mediated Transcription Repression and MDM2 Overexpression in Lung Cancer. J Thorac Oncol. 2014;9: 1305-1315.(Co- first authors) 43. Jen-Yu Hung, Shyh-Ren Chiang, Ming-Ju Tsai, Ying-Ming Tsai, Inn-Wen Chong, Jiunn-Min Shieh, Ya-Ling Hsu. LIGHT is a Crucial Mediator of Airway Remodeling. J.Cell. Physiol. 2015 May;230(5):1042-53. 44. Jiunn-Min Shieh, Chih-Jie Shen, Wei-Chiao Chang, Hung-Chi Cheng, Ya-Yi Chan, Wan-Chen Huang, Wen-Chang Chang, Ben-Kuen Chen. An Increase in Reactive Oxygen Species by Deregulation of ARNT Enhances Chemotherapeutic Drug-Induced Cancer Cell Death. PLOS one, 2014;9(6): e99242. 45. Jiunn-Min Shieh, Yih-Jeng Tsai, Chih-Jen Tsou, Wen-Bin Wu.CXCL1 Regulation in Human Pulmonary Epithelial Cells by Tumor Necrosis Factor. Cell Physiol. Biochem. 2014;34:1373-1384. 46. Jiunn-Min Shieh, Yen-An Tang, Tsung-Han Yang, Chih-Yi Chen, Han-Shui Hsu, Yi-Hung Carol Tan, Ravi Salgia, Yi-Ching Wang. Lack of Association of C-Met-N375S Sequence Variant with Lung Cancer Susceptibility and Prognosis. Int.J.Med.Sci.2013; 10(8):988-994. 47. S-C. Hsing, S-F. Weng, K-C. Cheng, J-M. Shieh, C-H. Chen, S-R. Chiang, J-J. Wang. Increased risk of pulmonary tuberculosis in patients with previous non-tuberculous mycobacterial disease. Int. J. Tuberc. Lung Dis. 2013,17(7):928-933. 48. Jia-Yang Chen, Yen-An Tang, Wen-Shan Li, Yu-Ching Chiou, Jiunn-Min Shieh*, Yi-Ching Wang*. A Synthetic Podopyllotoxin Devirative ExertsAnt-Cancer Effects by Inducing Mitotic Arrest and Pro-Apoptotic ER Stress inLung Cancer Preclinical Models. PLoS one, 2013, April: e62082. (Corresponding author) 49. Shian-Chih Ko*, Chi-Ruei Huang*, Jiunn-Min Shieh, Jhen-Hong Yang, Wen-Chang Chang, Ben-Kuen Chen. Epidermal Growth Factor Protects Squamous Cell Carcinoma against Cisplatin-Induced Cytotoxicity through Increased Interleukin-1β Expression. PLOS one, 2013,8(2): e55795 50. Jiunn-Min Shieh, Yung-Chan Chen, Yin-Chao Lin, Jia-Ni Lin, Wei-Chih Chen,Yang-Yuan Chen, Chi-Tang Ho, Tzong-Der Way. Demethoxycurcumin Inhibits Energy Metabolic and Oncogenic Signaling Pathways through AMPK Activation in Triple-Negative Breast Cancer Cells. J.Agric.Food Chem.2013, 61, 6366-6375. 51. Huey-Ming Lo, Jiunn-Min Shieh, Chih-Li Chen, Chih-Jen Tsou, Wen-Bin Wu. Vascular Endothelial Growth Factor Induces CXCL1 Chemokine Release via JNK and PI-3K-Dependent Pathways in Human Lung Carcinoma Epithelial Cells. Int.J. Mol.Sci.2013,14, 10090-10106. 52. Jiunn-Min Shieh, T.-T. Wei, Y.-A. Tang, S.-M. Huang, W.-L. Wen, M.-Y. Chen, S.B. Salunke, C.-T. Chen, C.-S. Chen, Y-C Wang. Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models. PLoS one, 2011,7(1): e30240. 53. Hung-Jen Tang, Yin-Ching Chung, Wen-Chien Kp, Chi-Chung Chen, Jiunn-Min Shieh, Chung-Hua Chen, Nan-Yao Lee, Shyh-Ren Chiang. Comparative evaluation of intratracheal colistimethate sodium, imipenem, and meropenem in BALB/c mice with carbapenem-resistant Acinetobacter baumannii pneumonia. Int J Infect Dis, 2012; 1,16(1):e34-e40. 54. Jiunn-Min Shieh, Tsan-Hwang Cheng, Ming-Der Shi, Pei-Fen WU, Yi Chen, Shian-Chin Ko, Yuan-Wei Shih. α-Tomatine Suppresses Invasion and Migration of Human Non-Small Cell Lung Cancer NCI-H460 Cells Through Inactivation FAK/PI3K/Akt Signaling Pathway and Reducing Binding Activity of NF-κB. Cell Biochem Biophys, 2011; 60,297-310. 55. Nai-Ding Liao, Jiunn-Min Shieh, Wen-Ying Lee.Diagnostic Value of Metabolic Phenotypes in Malignant Pleural Effusions: expression of GLUT1 and CAIX by immunocytochemistry. Cancer Cytotopatho 2011,published online (I.F:2.77, ranking 21/76=28% on pathology) 56. Jiunn-Min Shieh, Tur-Fu Hung, Chi-Feng Hung, Kuan-Hsien Chou, Yih-Jeng Tsai and Wen-Bin Wu. Activation of c-Jun N-terminal kinase is essential for mitochondrial membrane potential change and apoptosis induced by doxycycline in melanoma cells. British Journal of Pharacology, 2010; 160:1171-1181. 57. Pin-Liang Chen, *Jiunn-Min Shieh, Shiann-Chin Ko. Two Synchronous Primary Lung Cancers: A case Report. Thorac Med 2010; 25: 85-90. 58. Jiunn-Min Shieh, Hung-Tsung Wu, Kai-Chun Cheng, Juei-Tang Cheng. Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCζ-Akt-GSK3β pathway in hepatic cells. J. Pineal Res. 2009; 47:339-344.(sci) 59. Jiunn-Min Shieh, Tai-An Chiang, Wen-Teng Chang, Chang-Hung Chao, Yi-Chieh Lee, Guan-YuHung, You-Xin Shih, Yuan-Wei Shih. Plumbagin inhibits TPA-induced MMP-2 and u-PA expressions by reducing binding activitis of NF-κB and AP-1 via ERK signaling pathway in A549 human lung cancer cells. Mol Cell Biochem. 2009; 335,181-193.(sci) 60. Yuan-Wei Shih, Jiunn-Min Shieh, Pei-FenWu, Yi-Chieh Lee, Yi-Zhi Chen, Tai-An Chiang.α-Tomatine inactivates PI3K/Akt and ERK signaling pathways in human lung adenocarcinoma A549 cells: Effect on metastasis. Food and Chemical Toxicology. 47(2009) 1985-1995.(sci) 61. Ching-Yih Lin, Shih-Bin Su, Chih-Ching Chang, Tsung-Ming Lee, Jiunn-Min Shieh, How-Ran Guo. The Association Between Chlamydia Pneumoniae and Metabolic Syndrome in Taiwanese Adults. Southern Medical Journal.2009; 102(12) 62. Cheng-Ta Yang, Jen-Yu Hung,Chun-Liang lai, Hsin-Chia Hung, Yung-Fa Lai, Meng-Chih Lin, Jiunn-Min Shieh, Ming-Shyan Huang. Gefitinib as First- Line Therapy for Advanced or Metastatic NSCLC Patients in Southern Taiwan. Kaohsiung J Med Sci. 2010, 26:1-7. 63. Chi-Feng Hung, Tur-Fu Huang, Bing-Huei Chen, Jiunn-Min Shieh, Pi-Hui Wu and Wen-Bin Wu. Lycopene Inhibits TNF-alfa-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion. European Journal of Pharmacology:volume 586, issues 1-3, 31 May 2008, P275-282. 64. Hsin-Kai Huang, Chih-Hsiung Chen, Shian-Chih Ko, Kuo-Chen Cheng, Jiunn-Min Shieh, Kuo-Hwa Chaing. Anterior Mediastinal Type B3 Invasive Thymoma with Multiple Intrapulmonary Metastasses: A Case Report. Thorax Med 2008; 23: 355-361. 65. Chih-Hsiung Chen, Kun-Ming Chung, Jiunn-Min Shieh, Shian-Chin Ko,Hsiu-Nien Shen Kuo-Chen Cheng. Hemophagocytic Syndrome Associated with Diffuse Large-B-Cell Lymphoma: A case Report. Thorac Med 2008; 23: 55-60.