Mohamed Ali Shafie
PERSONAL DATA:
First name: Mohamed
Middle name: Ali
Last name: Attia Shafie
Address:
Faculty of Pharmacy – Assiut University
Phone: 088/2335156
Email:
Mobile:
0112727999
Mattiashafie@yahoo.com
Date of birth: Sept. 4, 1946
Nationality:
Egyptian
Marital Status: Married
Academic Degrees:
Bachelor
University:
Assuit
Major:
Pharmacy and Pharmaceutical Chemistry
Year:
1969
Year:
1972
Year:
1978
Master
University:
Assiut
Major:
Pharmaceutics
PHD
University:
First Medical Institute-Mosco- USSR
Major:
Formulation of Ophthalmic Preparations
Habilitation
University:
Major:
Year:
Teaching Experience:
Name of Institution
Assiut University
From – To
2002 - 2006
Job Title
Professor and Head of Pharmaceutics
Department .
Courses taught
Biopharmaceutics – Dosage form design .
Name of Institution
Misr International University
From – To
2004 – 2006
Job Title
Part time position
Courses taught
Technology of Dosage forms and Dosage
Form design .
Name of Institution
Assiut University
From – To
1986 – 1990
Job Title
Professor of Pharmaceutics
Courses taught
Post-graduate students in field of
Pharmaceutics .
Professional Experience: (non-academic)
Company/ Institution
Liptis Pharmaceutcals
From – To
2004 – 2006
Job Title/Department
Consultant
Job description
Share in design of the company building.
Formulation of new products.
Follow-up the production of market
Products .
Company/ Institution
Cid – Pharmaceutical company
From – To
1994 – 2005
Job Title/Department
Cosultant
Job description
Propose new products .
Follow- up the production of some products .
Solve problems raised during production .
Company/ Institution
T3A pharmaceutical company
From – To
1999 – 2000
Job Title/Department
Production Manager
Manage the production of different
Pharmaceutical dosage forms .
Job description
Research Experience:
Name of Institution
Assiut University
From – To
1994 – 2006
Job Title
Prof. of Pharmaceutics
Research field
Ophthalmic preparations .
Buccal Delivery .
Oral delivery of Protein and Peptide .
Name of Institution
Pharmedic Company – USA
From – To
1990 – 1991
Job Title
Scientist
Research field
Development of some Dosage
Preparations .
Improve the stability and release of some
Drugs from different forms .
Name of Institution
Applied Analytical Industries - USA
From – To
1991 – 1994
Job Title
Senior Scientist .
Research field
Developing many products in different
Dosage forms .
Areas of Research Interest:
Design of Ophthalmic preparations .
Oral delivery of protein and peptide .
Transdermal delivery .
Conferences:
 Controlled release of bioactive materials conference, basel, switzerland,
August, 1988.
 Controlled release conference, Illinois, U.S.A., 1989.
 A.A.P.S. conference, Las Vagus, U.S.A., 1990.
 A.A.P.S. conference, Washington D.C., 1992.
 Egyptian pharmaceutical sciences, Cairo, Egypt, 1995.
 Assiut University 1st Pharmaceutical sciences conference, 1998.
 Assiut University 2nd Pharmaceutical science, conference, 2000.
 Round table discussion and about "Environmental pollution health
problems-Diagnosis, prevention and treatment from 18 to 23 May, 1996.
Assiut University.
 Egyptian pharmmaceutical Sciences conference, Cairo, Egypt, 2004 .
Publications:
1. Mohamed Ali Attia Shafie1 and Mai Ahmed Hassan Rady: In
vitro and In vivo Evaluation of Timolol Maleate Ocular Inserts Using
Different
Polymers.
Journal
of
Clinical
and
Experimental
Ophthalmology. 3(8), 1-9, 2012
2. Mohamed Attia , Mohamed El Azizi, Mohamed S. Hashish :
Design and Evaluation of Ciprofloxacin hydrochloride Ocular Inserts .
J. Pharmacy and Pharmacology. InternationaL Journal of PharmTech
Research. 3(3): 1750-1763, 2011.
3. Mohamed Attia, Heba Y. El Badawy : Film forming gel for
treatment of oral mucositis : In-Vitro studies . International J. of Drug
Delivery 2, 314 – 2, 2010.
4. Mohamed Attia, Heba Y. El Badawy : Film forming gel for
treatment of oral mucositis : In-Vitro studies . International J. of Drug
Delivery 2, 314 – 21, 2010
5. Gihan Fetih, Habib Fawsia, Naoki Okada, Takuya Fujita,
Mohamed Attia and Akira Yamamoto : Colon-Specific delivery
and enhanced colonic absorption of [ Asu ]- eel Calcitonin using
Chitosan Capsules containing Various Additives in Rats . J. Drug
Target,14(3): 165 – 72, 2006 .
6. Gihan Fetih, Fawsia Habib, Hidmasa Katsum, Naoki Okada,
Takuya Fujita, Mohamed Attia, and Akira Yamamoto : Excellent
Absorption Enhancing Characteristics of NO Donors for improving
the Intestinal Absorption of Poorly Absorbable Compound Compared
with
Conventional
Absorption
Enhancers
.
Drug
Metab.
Pharmacokinet. Vol. 21, No. 3, 2006 .
7. Attia, M. A. et. al. Nitric oxide donors can enhance the intestinal
transport and absorption of insulin and [ Asu1,7] -eel calcitonin in rats
. J. Control. Release 106, 287 – 297, 2005 .
8. Attia, M. A. et. al. Improvement of absorption enhancing effects of ndodecyl- B - D -maltopyranoside by its colon-specific delivery using
chitosan capsules Int. J. Pharmaceutics 293, 127 – 135, 2005 .
9. Attia, M.A. et. al. Transbuccal permeation, anti-inflammatory activity
and clinical efficacy of piroxicam formulated in different gels . Int. J.
Pharmaceutics 267, 11 – 28, 2004 .
10.Attia, M.A. et. al. Ocular Bioavailability of Prednisolone Multiple
Emulsion Delivery Systems . Bull. Pharm. Sci. Assiut Univ., Vol. 17,
Part 2, 1995
11.Abd-Elmageed, A.; Attia, M.A.; Masoud A.A.; Abd-Elotaleb,
M.E.: Performance of propranolol hydrochloride ophthalmic
preparations in the eye of human patients. Mans. J. Pharm. Sci.,
14(1): 129-142, 1998.
12.Attia, M.A.; Habib, F.S.; Mohamed, A.A.; El-Badry, M.: In-vitro
and in-vivo studies on propranolol hydrochloride ophthalmic
solutions. Int. Conf. Pharm. Ind., Abs. Book 30, May , AlexandriaEgypt, 1990.
13.Attia, M.A.; Habib, F.S.; Mohamed, A.A.; El-Badry, M.: In-vitro
release and in-vivo performance of propranolol hydrochloride from
ophthalmic gels. Int. Conf. Pharm. Ind., Abs. Book 30, May,
Alexandria-Egypt, 1990.
14.Attia, M.A.; Kassem, M.A.; Safwat S.M.; El-Mahdy, M.M.: The
formulation-performance relationship of multiple emulsions and
ocular activity. J. of controlled release. 32, 259 - 268, 1994.
15.Attia, M.A.; Kassem, M.A.; Safwat S.M.; El-Mahdy, M.M.:
Preparation and evaluation of Hydrocortisone Multiple emulsions
in rabbits eye. J. die Pharm. Ind. 56(6), 584 - 588, 1994.
16.Attia, M.A.; Kassem, M.A.; Safwat S.M.; El-Mahdy, M.M.:
Influence of the phase volume ratio of multiple emulsions on the
ocular activity of prednisolone. J.S.T.P. Pharma Sciences. 5(4)
309-315, 1995.
17.Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.:
Refinement of Current Theories Underlying the mechanisms of
action of viscolizers in ophthalmic preparations. 16 th inter.
Symposium on controlled release of Bioactive Materials, Chicago,
Illinois, U.S.A., 1989.
18.Attia, M.A.; Kassem, M.A.; Safwat, M.S.: In-vitro and In-vitro
release of C-Mofebutazone from ocular polymeric inerts. 16 th
Inter. Symposium on controlled Release of Bioactive Materials,
Chicago, Illinois, U.S.A., 1989.
19.Attia, M.A.; Kassem, M.A.; Schulte, Karl E.: Patent DE 35 33
635 C2 West Germany, 1988.
20.Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: Effect
of phenylephrine hydrochloride on betamethasone side effect in
relation to viscosity of ophthalmic preparations. II. Gel. State.
Drug Development and Industrial Pharmacy, 15(2), 1989.
21.Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: Effect
of phenylephrine hydrochloride on betamethasone side effect in
relation to viscosity of ophthalmic preparations. I. Viscous
Solutions. Drug Development and Industrial Pharmacy, 15(2),
1989.
22.Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.:
Influence of phenylephrine hydrochloride on the anti-inflmmatory
effect of betamethasone in the eye of rabbit. 15 th inter. Symp. on
Controlled Release of Bioactive Materials. Basel-Switzerland,
August, 1988.
23.Attia, M.A.; Kassem, M.A.; Safwat, S.M.: In-vivo performance of
H-dexamethasone ophthalmic film delivery system in rabbit eye.
Inter. J. of Pharmaceutics, 47, 21 – 30, 1988.
24.Attia, M.A.; Kassem, M.A.; Safwat, S.M.: Impact of formulation
factors on Pharmacokinetics of H-dexamethasone in ocular tissues.
15th Inter. Symp. On controlled release of bioactive materials.
Basel-Switzerland, August, 1988.
25.Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: In-vivo
performance of opththalmic preparations of betamethasone and
phenylephrine hydrochloride in the rabbit eye.
II. Effect of
methylhydroxyethylcellulose. Drug Development and Industrial
Pharmacy, 13(8), 1987.
26.Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: In-vivo
performance of ophthalmic solutions of betamethasone and
phenylephrine hydrochloride in the eye of rabbit. I. Effect of
Methylcellulose. J. Drug Development and Industrial Pharmacy,
13(8), 1987.
27.Attia, M.A.; Habib, F.S.: Permeability of phenylephrine
hydrochloride through the cornea of rabbits. J. de Pharmazeutische
Industrie, 48(11), 1986.
28.Attia, M.A.; Habib, F.S.: In-vitro study of physostigmine
salicylate and pilocarpine hydrochloride release from different gel
formulations. J. Die Pharmazie, 41. H. 2, 1986.
29.Attia, M.A.; Habib, F.S.: Effect of polyol type on the In-vitro
release of prednisolone from oil-in-water type ointment. J. Pharm.
Ind., 48(11), 1986.
30.Attia, M.A.; El-Sourady, H.A.; El-Shanawany, S.M.: Release and
rheological
characteristics
of
chloramphenicol
ophthalmic
ointments. J. Pharm. Ind., 48(10), 1986.
31.Attia, M.A.; Kassem, M.A.; Safwat, S.M.: Effect of formulation
variables on the permeation of dexamethasone through different
polymeric films.
I. Effect of different polymer type and
plasticizers. J.S.T.P. Pharma, 2(12), 1986.
32.Attia, M.A.; Kassem, M.A.; Safwat, S.M.: Effect of formulation
variables on the permeation of dexamethasone through different
polymeric films. II. Effect of different surfactants. J.S.T.P.
Pharma, 2(13), 1986.
33.Attia, M.A.; Kassem, M.A.; Safwat, S.M.: In-vitro release of
dexamethasone from polymeric inserts. J. Pharm. Belg. 41(2),
1986.
34.Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: In-vivo
performance of ophthalmic preparations of betamethasone and
phenylephrine hydrochloride in the rabbit eye: Effect of polyvinyl
alcohol. Pharmaceutical Research. 3(4), 1986.
35.Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.: In-vitro
release study of betamethasone and phenylephrine hydrochloride
from ophthalmic preparations. Intern. J. of Pharmaceutics, 29,
1986.
36.Attia, M.A.; Habib, F.S.; Kassem, M.A.; Mohamed, A.A.:
Activity of ophthalmic gels of betamethasone and phenylephrine
hydrochloride in the rabbits eye. Intern. J. Pharmaceutics, 32,
1986.
37.Attia, M.A.; Habib, F.S.: Pilocarpine delivery from multiple
emulsions. J. S.T.P. Pharma, 2(18), 1986.
38.Attia, M.A.; Habib, F.S.: Ocular delivery of pilocarpine
hydrochloride from water soluble polymeric inserts. Acta Pharm.
Technol. 32(3), 1986.
39.Attia, M.A.; El-Sourady, H.A.; El-Shanawany, S.M.: Vehicle
influence on ocular disposition of chlortetracycline hydrochloride
and chloramphenicol in albino rabbit.
Acta Pharmaceutica
Technologica, 31(2), 1985.
40.Attia, M.A.; Habib,
F.S.; El-Shanawany, S.M.:
Ocular
bioavailability of pilocarpine hydrochloride in combination with
physostigmine salicylate from different gel formulations. Arch.
Pharm. Chem. Sci. Ed., 13, 1985.
41.Attia, M.A.; Habib, F.S.; El-Shanawany, S.M.: Effect of different
ointment bases on ocular disposition of ethylphenylephrine in
rabbit eyes. Inter. J. Pharmaceutics 26, 1985.
42.Attia, M.A.; Habib, F.S.: Dissolution rates of carbamazepine and
nitrazepam utilizing sugar solid dispersion system. Drug
Development and Industrial Pharmacy, 11(11), 1985.
43.Attia, M.A.; Habib, F.S.: Effect of particle size on dissolution rate
of monophenyl-butazone solid dispersion in presence of certain
additives. Drug Development and Industrial Pharmacy, 11(11),
1985.
44.Attia, M.A.; El-Sourady, H.A.; El-Shanawany, S.M.: Stability of
chlortetracycline hydrochloride and chloramphenicol in some
ophthalmic ointment bases. J. Die. Pharmazie, 40, H. 9, 1985.
45.Attia, M.A.; Habib, F.S.: Comparative study of the ocular activity
in rabbit eyes of adrenaline bitartrate formulated in carbopol and
poloxamer gels. Arch. Pharm. Chem. Sci. Ed., 12, 1984.
46.Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of different
disintegrants
on
the
avalilability
of
directly
compressed
sulphadimidine tablets. J. Die Pharmazie, 38, H. 7, 1983.
47.Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.:Effect of certain
organic and inorganic additives on the flocculation of suspensions
containing different sulphonamides. Bull. of Pharm. Sci., Assiut,
Vol. 6, Part 1, 1983.
48.A Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Study on the
dissolution
of
diazepam
from
its
solid
dispersion
and
coprecipitates in the presence of various concentrations of nonionic surfactants. J. die. Pharmazie, 37, H. 4, 1982.
49.Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Dissolution study on
sulfisoxazle, sulphapyridine and sulphamerazine from their solid
dispersions and coprecipitates. Bull. of Pharm. Sci. Assiut, Vol. 5,
1982.
50.Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of directly
compressible vehicles on uniformity of contents of oxytetracycline
hydrochloride tablets. Bull. Of Pharm. Sci., Assiut, Vol. 5, 1982.
51.Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of certain
ophthalmic preparations containing pilocarpine hydrochloride and
dexamethasone on the intraocular pressure of rabbits eye. Bull. Of
Pharm. Sci., Assiut, Vol. 5, 1982.
52.Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: A study on the release
of prednisone from new ointment bases containing various
additives. J. Die. Pharmazie, 36(1), 1981.
53.Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of micellar
structure on the solubility of prednisone and prednisolone. Indian.
J. of Pharmacy, 43(1), 1981.
54.Attia, M.,A.; Habib, F.S.; Aboutaleb, A.E.: Effect of certain
additives on the solubilization of dexamethasone. J. Drug
Research, Egypt, 13(1-2), 1981.
55.Attia, M.A.; El-Sourady, A.; El-Shanawany, S.M.: Release and
rheological characteristics of chlortetracycline hydrochloride
ophthalmic ointments. Bull. Pharm. Sci., Assiut, Vol. 4, 1981.
56.Attia, M.A.; Habib, F.S.; Aboutaleb, A.E.: Effect of surfactant
structure on the release of dexamethasone from different ointment
bases. Bull. Of Pharm. Sci. Assiut (3), 1980.
57.Sina, A.; Youssef, M.K.; Kassem, A.A.; Attia, M.A.: Effect of
Sorption and Leaches of Plastic Granules on the stability of
antimicrobial agents and antioxidants. Indian, J. Pharmacy, 35(2),
1973.
58.Sina, A.; Youssef, M.K.; Kassem, A.A.; Attia, M.A.: Leaches and
Water Sorption of Polyethylene and Polyvinyl chloride. Indian, J.
Pharmacy, 34(4), 1972.
Titles Of Thesis Performed Under My Supervision
MSc. Thesis
1. Formulation and Evaluation studies on Topical Emulgel Containing
Meloxicam, 2012. (German University)
2. Formulation and Evaluation of Metochlopramide-loaded Solid Lipid
Nanoparticles for Rectal Delivery, 2012. (German University)
3. Design and Evaluation of Ocular Inserts Containing Timolol Maleate,
2011. (German University)
4. Design and Evaluation of Ciprofloxacin Hydrochloride Ocular Inserts,
2011. (German University)
5. Film Forming Gel Containing Diclofenac Sodium, Ofloxacin and
Their Combination for Treatment of Oral Mucositis, 2010. (German
University)
6. Formulation and Evalauation Studies on Buccal Gels Containing
Piroxicam, 2000. (Assiut University)
7. Pharmaceutical Study of Certain Corticosteroids in Multiple
Emulsion, 1992. (Assiut University)
8. Performance of Propranolol Hydrochloride in Certain Ophthalmic
Preparations, 1991. (Assiut University)
Doctor Philosophy Degree:
1. Oral Delivery of Certain Peptide Derivatives, 2005 (Assiut University
)
2. Biopharmaceutical
Studies
of
Certain
Corticosteroids
and
Phenylehrine Hydrochloride in Ophthalmic Preparations, 1985.
(Assiuy University)
3. Design and Evaluation of Polymer-based Films as Ophthalmic Dru
Delivery Systems, 1984. (Assiut University)
4. Formulation and availability Studies of Some Antibiotics From Eye
Ointment Bases, 1993. (Assiut University)
Thesis Reviewed by myself
1. Preparation and Evaluation of Controlled Release Ketoprofen Oral
Formulations, 2012. (Assiut University)
2. A Niosomal Encapsulation of Amikacin Sulfate for Increasing its
Efficacy and Safety, 2012. (Al Azhar University)
3. Incorporation of Chemotherapeutic Agents into Nano or Micro
Particles to be Administered by Routes Other than I.V. Systems, 2011.
(Beni-Suef University)
4. Unfractionated Heparin Versus Low Molecular weight Heparine in
the Treatment of Deep Venous Thrombosis: Impact of Pharmaceutical
Care, 2008. (Helwan University)
5. Formuation and Evaluation of Some Tinidazole Preparations
Containing Certain Bioadhesives, 2004. (Mansoura University)