Margaret Rosenfeld, M.D., M.P.H. Curriculum Vitae EDUCATION l983 l988 1995 B.S., Molecular Biophysics and Biochemistry, Yale University, New Haven, CT. Magna cum laude, Distinction in the Major M.D., Harvard Medical School, Boston, MA M.P.H., Department of Epidemiology, University of Washington School of Public Health, Seattle, WA POSTGRADUATE TRAINING l988-91 Internship/Residency in Pediatrics, University of Washington School of Medicine/Children's Hospital and Medical Center, Seattle, WA l992-95 Fellowship, Pediatric Pulmonology, University of Washington School of Medicine, Seattle, WA FACULTY POSITIONS HELD 1995-1998 Acting Instructor, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 1999-2000 Acting Assistant Professor, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 2000Assistant Professor, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA HOSPITAL POSITIONS HELD 1995-present Attending Physician, Children’s Hospital and Regional Medical Center, Seattle, WA HONORS 1992-98 1993 Leroy Matthews Physician Scientist Award, Cystic Fibrosis Foundation Physician Scientist Fellowship Award, Glaxo Corporation BOARD CERTIFICATION l993 Diplomate, American Board of Pediatrics 1998 Diplomate in Pediatric Pulmonology Margaret Rosenfeld, MD, MPH Page 2 LICENSURE l988- State of Washington, # 00027801 PROFESSIONAL ORGANIZATIONS American Academy of Pediatrics Washington State Society of Pediatrics American Thoracic Society Washington Thoracic Society Western Society for Pediatric Research Society for Pediatric Research Association for Patient Oriented Research TEACHING RESPONSIBILITIES Courses: 1991Housestaff noon conference didactic sessions on chronic cough, obstructive sleep apnea, and common airway disorders (each given annually) 1992Visiting lecturer, NURS 517 (Pediatric Nurse Practitioner graduate course), University of Washington School of Nursing (annually) 1995Attending physician, housestaff morning report (bi-weekly) 1995Attending rounds didactic sessions to resident ward team on various relevant topics in pediatric pulmonary medicine (cystic fibrosis, pulmonary physiology, asthma, bronchiolitis) 1995-2002 Visiting lecturer, Core Pediatrics Clerkship, University of Washington School of Medicine (~ 6 times annually) 2001 Visiting lecturer, GEN 531 (Genetics graduate seminar) 2002Lecturer, Core Pediatrics Clerkship, ethics session (9 times annually) 2003Lecturer, HuBio 512 course to 1st year medical students (lecture on cystic fibrosis) CME: 1. “The Use Of Aerosolized Antibiotics In The Treatment Of CF Children Under Six,” national teleconference sponsored by Pathogenesis Corp., Seattle, WA, July 19, 2001. Category 1 CME through UWSOM. 2. “Early Intervention in Cystic Fibrosis Lung Disease,” Grand Rounds, CHRMC, 8/23/01. Trainees: 1997-1999 2000 2001 Graduate thesis preceptor for Toby Lewis, M.D., M.P.H., University of Washington School of Public Health and Community Medicine Research mentor for Victoria Cartwright, MD, fellow in Pediatric Rheumatology, “A Randomized, Controlled Trial of Pain Management Methods for Intraarticular Steriod Injections in Patients with Juvenile Rheumatoid Arthritis.” Research mentor to Chris Goss, MD, MSc, Acting Instructor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, UWSOM. Assisted him in preparation of his grant applications to the Cystic Fibrosis Margaret Rosenfeld, MD, MPH Page 3 2001 2001- 2002- 2003 Foundation for a LeRoy Matthews Physician Scientist Award and to the NIH for a K23 award. His proposals assess the quality of life in cystic fibrosis patients with end-stage lung disease. Research mentor to Julie Brown, MD, MPH, senior fellow, Division of Emergency Medicine, “Validation of a Clinical Bronchiolitis Score.” Assisting in K23 grant application preparation and serving as a member of her research advisory committee. Research mentor to Jason Debley, MD, senior fellow, Division of Pulmonary Medicine. Assisted him in revising his protocol and application for his study entitled, “The utility of thoracic index to identify high-risk infants following RSV lower respiratory infection” and in preparing his K23 application to assess predictors of asthma among wheezy infants. Advisor to Doris Uh, Pharm.D., postdoctoral fellow, Department of Pharmaceutics. Mentoring her in investigation of pharmacokinetics of inhaled antibiotics and supervising her role as consulting clinical pharmacist in the Division of Pulmonary Medicine. Research mentor to Martha McKinney, MD, MPH. Assisted her in her preparing her thesis in fulfillment of the Masters in Public Health degree, assessing the prevalence of smoking among Canadian asthmatics. Sat on her thesis committee. EDITORIAL RESPONSIBILITIES None SPECIAL NATIONAL RESPONSIBILITIES 1999Participant in development of Pulmonology subspecialty examination, American Board of Pediatrics 1999 Correspondent Reviewer, NIDDKM K01 grant application 2001Co-principal investigator, Epidemiologic Study of Cystic Fibrosis 2002Nominating Committee member, Pediatric Assembly, American Thoracic Society 2002Member American Thoracic Society Health Care Policy Committee 2002Member, Cystic Fibrosis Foundation Therapeutics Development Network Protocol Review Committee 2002 Manuscript judge, 2003 Uniformed Services Scientific Award Competition 2003Member, Cystic Fibrosis Foundation National Patient Registry Committee 2003Member, American Thoracic Society Pediatric Assembly Planning Committee SPECIAL LOCAL RESPONSIBILITIES 1997-2000 Subspecialty Teaching Ad Hoc Subcommittee of the Residency Committee, Children’s Hospital and Regional Medical Center 1997Residency Program Liaison, Division of Pulmonary Medicine, Children’s Hospital and Regional Medical Center 1998Medical Director, Pulmonary Function Laboratory, Children’s Hospital and Regional Medical Center Margaret Rosenfeld, MD, MPH Page 4 1999, 2002 19992000-2003 2001-2002 2001200120022003- Reviewer, Cystic Fibrosis Critical Elements of Care Community Provider Guidelines, Center for Children with Special Needs and Chronic Health Conditions, CHRMC Member, Scientific Advisory Committee to the Clinical Research Center, UW and CHRMC. Member, UW Clinical Research Training Grant K-30 Steering Committee – Training Grant Program Track Member, Newborn Screening Advisory Committee to Washington State Board of Health regarding additional universal newborn screening tests. Member, CHRMC Pharmacy and Therapeutics Committee Member, Medical Advisory Board, World Bike for Breath Member, Academic Career Advisory Group for UW Pediatric Residents Co-Fellowship Coordinator, Department of Pediatrics, CHRMC RESEARCH FUNDING 1. Cystic Fibrosis Foundation, Leroy Matthew Physician Scientist Award, 1992-1998. 1997-98 budget: $65,250 . 2. Pari Respiratory Equipment, for Study of Efficacy of Cleaning Methods for SmallVolume Nebulizers, $1,847, 1997. 3. PathoGenesis Corp., for Safety Study of Aerosolized Tobramycin in Young Children with Cystic Fibrosis, $90,591, 4/98 – 10/98. 4. PathoGenesis Corp. and Cystic Fibrosis Foundation, for A Pilot Study of the Deposition of Inhaled Tobramycin in Young Children with Cystic Fibrosis, 4/99-5/00.. Total award to Therapeutic Development Network coordinating center and participating sites: $81,968. 5. Clinical Associate Physician (CAP) Award K23 RR15529, National Center for Research Resources, NIH. Award period 5/00 – 4/05. First year annual budget $103,800. 6. CHRMC Research Endowment Fund. A pilot study of sputum induction as a noninvasive means to measure serial airway antibiotic concentrations in cystic fibrosis (M. Rosenfeld, PI). Direct costs $29,800 over 2 years begin in 2002. 7. Cystic Fibrosis Foundation Clinical Research Grant ROSENF03A0, “Evaluation of Expiratory Flows from Raised Volumes as Outcome Measures for Clinical Trials in Infants with Cystic Fibrosis.” Award period: 2003-2006. Total award: $1 million. Margaret Rosenfeld, MD, MPH Page 5 Manuscripts in Refereed Journals 1. Rosenfeld M, Ramsey B. Evolution of airway microbiology in the infant with cystic fibrosis: role of pseudomonal and non-pseudomonal pathogens. Semin Respir Infect 1992;7(3):15867. 2. Rosenfeld M, Cohen M, Ramsey B. Aerosolized antibiotics for bacterial lower airway infections: principles, efficacy and pitfalls. Clinical Pulmonary Medicine 1997;4(2):101-12. (Also appeared in Infectious Diseases in Clinical Practice 1998:7;66-79) 3. Rosenfeld M, Davis R, Fitzsimmons S, Pepe M, Ramsey B. The gender gap in cystic fibrosis mortality. American Journal of Epidemiology 1997;145(9):794-803. 4. Rosenfeld M, Emerson J, Astley S, Joy P, Williams-Warren J, Standaert T, Yim DL, Crist D, Thykkuttathil J, Torrence M, FitzSimmons S, Ramsey B. Home nebulizer usage among patients with cystic fibrosis. Journal of Pediatrics 1998;132:125-31. 5. Rosenfeld M, Casey S, Pepe M, Ramsey B. Nutritional effects of long term gastrostomy feedings in children with cystic fibrosis. Journal of the American Dietetic Association 1999;99:191-4. 6. Rosenfeld M, Emerson J, Accurso F, Armstrong D, Castile R, Grimwood K, Hiatt P, McCoy K, McNamara S, Ramsey B, Wagener J. Diagnostic accuracy of oropharyngeal cultures in infants and young children with cystic fibrosis. Pediatric Pulmonology, 1999;28:321-328. 7. Rosenfeld M, Pepe MS, Emerson J, Longton G, FitzSimmons S. Effect of different reference equations on the analysis of pulmonary function data in cystic fibrosis. Pediatric Pulmonology 2001;31:227-37. 8. Burns JL, Gibson RL, McNamara S, Yim D, Emerson J, Rosenfeld M, Hiatt P, McCoy K, Castile R, Smith AL, Ramsey BW. Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fibrosis. Journal of Infectious Disease 2001;183(3):444-452. 9. Rosenfeld M, Emerson J, Willians-Warren J, Pepe M, Smith A, Montgomery AB, Ramsey BW. Defining a pulmonary exacerbation in cystic fibrosis. J Pediatr 2001;139(3):359-365. 10. Rosenfeld M, Gibson RL, McNamara S, Emerson J, Burns JL, Castile R, Hiatt P, McCoy K, Wilson CB, Inglis A, Smith A, Martin TR, Ramsey BW. Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis. Pediatric Pulmonology 2001;32:356-366. 11. Rosenfeld M, Gibson R, McNamara S, Emerson J, McCoy K, Shell R, Borowitz D, Konstan M, Retsch-Bogart G, Wilmott RW, Burns JL, Vicini P, Montgomery B, Ramsey B, MD. Serum and lower respiratory tract drug concentrations produced by tobramycin for inhalation in young children with cystic fibrosis. J Pediatr 2001;139(4):572-7 12. Emerson J, Rosenfeld M, McNamara S, Ramsey B, Gibson RL. Pseudomonas and other predictors of mortality and morbidity among young children with cystic fibrosis. Pediatr Pulmonol 2002;34(2):91-100. 13. Mayer-Hamblett N, Rosenfeld M, Emerson J, Goss CH, Aitken ML. Developing cystic fibrosis lung transplant referral criteria using predictors of 2-year mortality. American Journal of Respiratory and Critical Care Medicine 2002;166:1550-5 14. Gibson RL, Emerson J, McNamara S, Burns JL, Rosenfeld M, Yunker A, Hamblett N, Accurso F, Dovey M, Hiatt P, Konstan MW, Moss R, Retsch-Bogart G, Wagener J, Ramsey B. Significant microbiologic effect of inhaled tobramycin in young children with cystic fibrosis. Am J Respir Crit Care Med 2003;167: 841-9. Margaret Rosenfeld, MD, MPH Page 6 15. Geller DW, Rosenfeld M, Waltz D, Wilmott R. Efficiency of pulmonary administration of tobramycin solution for inhalation in cystic fibrosis using an improved drug delivery system. Chest 2003; 123:28-36 16. Kulich M., Rosenfeld M., Goss CH, and Wilmott R.. Improved survival among young patients with cystic fibrosis. J Pediatr 2003:142(6);631-636. 17. Rosenfeld M, Gibson R, Ramsey BW. Pseudomonas acquisition in young patients with cystic fibrosis: pathophysiology, diagnosis, and management. Curr Opin Pulm Med. 2003 Nov;9(6):492-7. Book Chapters 1. Marshall S, Rosenfeld M, Ramsey B. Respiratory System: Pediatrics. In Cystic Fibrosis, Hodson ME, Geddes DM, eds. Chapman and Hall Medical, London, 2000, pp. 204-218. Other Publications 1. Rosenfeld, M. The gender gap in cystic fibrosis mortality. Thesis submitted in partial fulfillment of the Masters in Public Health degree, University of Washington, Seattle, WA, August, 1995. 2. Rosenfeld M, Joy P, Nguyen CD, Burns J. Cleaning home nebulizers used by patients with cystic fibrosis: is rinsing with tap water enough? Journal of Hospital Infection 2001;49(3):229-30. Abstracts 1. Rosenfeld M, Ramsey B, Redding G, Castile R, McCoy K, Hiatt P. Changes in pulmonary function associated with pseudomonal respiratory colonization in infants with cystic fibrosis. Pediatric Pulmonology 1994;S10:262. 2. Castile R, Rosenfeld M, Drake J, Gadek J, McCoy K, Ramsey B. Relationship of adult-type lung function tests to bronchoalveolar lavage differential cell counts in infants with cystic fibrosis. Pediatric Pulmonology 1994;S10:262. 3. Rosenfeld M, Dowd MD, Mueller B. Maternal prenatal alcohol consumption as a risk factor for sudden infant death syndrome and infant injury death. Presented at Ambulatory Pediatrics Association meeting, Western Division, February, 1995. 4. Rosenfeld M, Davis R, Pepe M, Ramsey B. Differences in survival by gender among US cystic fibrosis patients. Pediatric Pulmonology 1995;S12:286. 5. Rosenfeld M. The gender gap in survival in cystic fibrosis. Pediatric Pulmonology 1996;S13:97-98. 6. Joy P, Rosenfeld M, Emerson J, Williams-Warren J, Yim D, Standaert T, Astley S, Torrence M, FitzSimmons S, Ramsey B. Home nebulizer usage among CF patients. Pediatric Pulmonology 1996;S13;309. 7. Rosenfeld M, Accurso F, Armstrong D,Castile R, Emerson J, Grimwood K, Hiatt P, McCoy K, Ramsey B, Wagener J. The diagnostic accuracy of oropharyngeal cultures relative to lower airway cultures in infants and young children with cystic fibrosis. Pediatric Pulmonology 1997;S14;295. 8. Rosenfeld M, Emerson J, Williams-Warren J, Pepe M, Ramsey B. Defining a pulmonary exacerbation in cystic fibrosis. Pediatric Pulmonology 1997;S14;295. Margaret Rosenfeld, MD, MPH Page 7 9. Rosenfeld M, Pepe M, Emerson J, FitzSimmons S. Effect of different reference equations on the analysis of pulmonary function data in CF. Pediatric Pulmonology 1998;S15,333. 10. Emerson J, Pepe M, Rosenfeld M, FitzSimmons S. Prognostic indicators in children with cystic fibrosis. Pediatric Pulmonology 1998;S15,403. 11. Ramsey B, McNamara S, Gibson R, Emerson J, Rosenfeld M, Hiatt P, McConnell R, McCoy K, Lawrence C, Olson P. P. aeruginosa (Pa) Colonization in Young Children with Cystic Fibrosis. Pediatric Pulmonology 1998;S15,320. 12. Rosenfeld M, Borowitz D, Emerson J, Gibson R, McCoy K, McNamara S, Montgomery B, Ramsey B, Vicini P, Wilmott B. Safety and serum pharmacokinetics of inhaled tobramycin in very young CF patients. Pediatric Pulmonology 1999;S19,262. 13. Lewis TC, Rosenfeld M, Gibson R, Ramsey B. Urban/rural differences in specialty health care utilization and health outcomes in cystic fibrosis. Pediatric Pulmonology 1999;S19,367. 14. Vicini P, Rosenfeld M, Borowitz D, Emerson J, Gibson R, McCoy K, McNamara S, Montgomery B, Ramsey B, Wilmott B. Population pharmacokinetics of inhaled tobramycin in CF patients <6 years of age. PharmSci 1999; S1(4): 1602-1603. 15. Rosenfeld M., Mayer Hamblett N., Goss C.H., Aitken M.L., Emerson J., Kronmal R.. Predictors of two year mortality in CF. Pediatric Pulmonology 2000; supp 20; 316. 16. Rosenfeld M, Burns JL, Joy P, Nguyen C, Krzewinski J. Cleaning home nebulizers: Is water enough? . Pediatric Pulmonology 2000: supp 20;291. 17. Rosenfeld M, Gibson R, McNamara S, Emerson J, Burns JL, Castile R, Hiatt P, McCoy K, Wilson CB, Smith A, Ramsey BW. Early course of pulmonary infection, inflammation and clinical outcomes in infants with cystic fibrosis. Pediatric Pulmonology 2000: supp 20;112113. 18. Wilmott, RW, Charfield B, Dyson, M, Geller D, Milgram L, Noone PG, Rodman D, Rosenfeld M, Waltz DA, Schaeffler B, Challoner P. Aerodose improves TOBI delivery in cystic fibrosis. Pediatric Pulmonology 2001: supp 22;292. 19. Goss CH, Kulich M, Rosenfeld M, Waltz DA, Wilmott RW. Most of the recent gains in survival in CF in the US have been in children ages 2-16 years. American Journal of Respiratory and Critical Care Medicine 2002:165 (8);A651. 20. Gibson RL, Emerson, J, McNamara S, Burns J, Rosenfeld M, Yunker A, Hamblett N, Accurso F, Dovery M, Hiatt P, Moss R, Konstan M, Retsch-Bogart G, Waltz D, Wilmott R, Wagener J, Zeitlin P, Ramsey B. A randomized, controlled trial of inhaled tobramycin in young children with cystic fibrosis: eradication of Pseudomonas from the lower airway. Pediatr Pulmonol 2002:s24;300 21. Campbell J, Kulich M, Rosenfeld M, Kronmal R. Pulmonary function reference curves for cystic fibrosis patients. Pediatr Pulmonol 2002:s24;332. 22. Rosenfeld M, Emerson J, McNamara S, Castile R, McCoy K, Hiatt P, Burns JL, Gibson R, Ramsey BW. Longitudinal followup of Pseudomonas aeruginosa infection in young children with cystic fibrosis. American Journal of Respiratory and Critical Care Medicine 2003 (abstract, in press). 23. Gibson RL, Emerson J, McNarmara S, Burns JL, Rosenfeld M, Hamblett N, Acton J, Borowitz D, Hiatt P, Konstan MW, Moss R, Restsch-Bogart G, Wagener J. Duration of the anti-pseudomonal treatment effect of inhaled tobramycin in young children with cystic fibrosis. Pediatr Pulmonol 2003; s25:295. Margaret Rosenfeld, MD, MPH Page 8 24. Rosenfeld M, Caron H, Emerson J, Hamblett N, Burns JL, Gibson R, McNamara S, Hiatt P, McCoy K, Castile R, Ramsey B. What effect do anti-pseudomonal antibiotics have on serial upper airway cultures in infants with CF? Pediatr Pulmonol 2003; s25:313. 25. Sagel SD, Emerson J, Rosenfeld M, McNamara S, Caron H, Ramsey B, Wagener J, Gibson R. Association of upper versus lower airway Pseudomonas aeruginosa infection with endobronchial inflammation and clinical status in young children with CF. Pediatr Pulmonol 2003; s25:313 OTHER Local invitational lectures 1. CF and Gene Therapy Investigator Seminars Series presentation “Gender Gap in Cystic Fibrosis Mortality,” July, 1997 2. “Newborn Screening for Cystic Fibrosis,” CF Annual Clinical Conference, Urban Horticulture Center, July 10, 1998 3. “Newborn screening for CF”, Annual Northwest CF Clinical Conference, Urban Horticulture Center, Seattle, July, 1998 4. “Predictors of Two Year Survival in Cystic Fibrosis,” presentation to the UW CF Epidemiology-Biostatistics Working Group, 1/00 5. “Cystic fibrosis: new modalities of therapy,” Graduate Division, UW School of Dentistry, 4/25/00 6. “Predicting survival in CF,” Presentation at CHRMC quarterly CF clinical conference, 1/01. 7. “Evaluation of Pulmonary Function Tests from Raised Lung Volumes as Outcome Measures for Clinical Trials in Infants with Cystic Fibrosis,” presentation to the UW CF EpidemiologyBiostatistics Working Group, 1/01 9. “Predicting survival in CF.” Presentation at CHRMC quarterly CF clinical conference, 1/01. 8. “Recurrent Wheezing in Infants: Diagnosis and Management,” National Initiative for Children’s Health Quality Asthma Quality Improvement Conference, Seattle, 4/6/01 (invited by Jim Stout, MD, and Lenna Liu, MD). 9. “Diagnosis of Management of the Wheezy Infant.” WWAMI Visiting Professor, Madrona Pediatrics Group, Bellingham, WA, July 18, 2001 10. “First Isolation of Pseudomonas aeruginosa: To Treat or Not To Treat?” Annual Northwest Regional Cystic Fibrosis Clinical Conference, Center for Urban Horticulture, Seattle. 11. “Early Intervention in Cystic Fibrosis Lung Disease.” Grand Rounds, CHRMC, Aug 23, 2001. 12. “Predictors of 2-year survival in CF.” UW CF Epidemiology / Biostatistics Working Group, Center for Urban Horticulture, 10/01. 13. “Predicting Short-Term Survival in Cystic Fibrosis,” Cystic Fibrosis And Gene Therapy Research Center Investigator’s Seminar Series, 2/11/02 14. “Developing Better Criteria for Lung Transplant Referral,” UW CF Epidemiology/Biostatistics Working Group, Center for Urban Horticulture, 7/03 15. “New Lung Function Tests in Infants with CF,” Cystic Fibrosis Clinical Conference, Center for Urban Horticulture, 9/03 Margaret Rosenfeld, MD, MPH Page 9 16. “Designing and Participating in Multicenter Clinical Trials: an Investigator’s Perspective,” Pediatric Clinical Research Center forum on Practical Aspects of Conducting Pediatric Clinical Research Trials, CHRMC, 10/27/03 17. “Lung Function Testing in Infants: Promising New Methods,” CHRMC Grand Rounds, 12/4/03 National invitational lectures “Safety and lower respiratory tract deposition of inhaled tobramycin in very young children with CF” Symposium presentation, North American Cystic Fibrosis Conference, Seattle, WA, October, 1999 2. “Gender differences in cystic fibrosis” Nutritionists’ workshop, North American Cystic Fibrosis Conference, Seattle, WA, October, 1999 3. Early CF lung disease and preliminary studies of the use of tobramycin for inhalation in infants with CF. Presentations at Phoenix Children’s Hospital and University of California, San Francisco, 10/00. 4. “Epidemiology as a Research Tool in Cystic Fibrosis,” co-director, Short Course, North American Cystic Fibrosis Foundation Annual Conference, 11/00, Baltimore, MD and 10/02, New Orleans, LA. 5. “Early infection, inflammation and clinical outcomes in infants with CF.” Symposium presentation, North American Cystic Fibrosis Foundation Annual Conference, 11/00, Baltimore, MD. 6. “The Use Of Tobramycin For Inhalation In Children With Cystic Fibrosis <6 Years Of Age.” Invited presentation at symposium on “Decisions facing the CF clinician at first Pseudomonas aeruginosa isolation,” Royal College of Physicians, London, July 6, 2001. 7. “The use of aerosolized antibiotics in the treatment of cystic fibrosis children under six,” CME teleconference sponsored by University of Washington and BioScience Communications, Inc. 8. “Early intervention in CF lung disease: completed research and current controversies." North American Cystic Fibrosis Foundation Conference, Orlando, FL, 10/01. 9. “Why is Asthma on the Rise?” Central Ohio Pediatrics Society, Columbus, OH, 2/20/02 10. “Early Intervention in Cystic Fibrosis Lung Disease: Balancing Benefits and Risks,” Grand Rounds, Columbus Children’s Hospital, Columbus, OH, 2/21/02 11. “The Wheezy Infant: Diagnosis and Management,” noontime presentation, Columbus Children’s Hospital, Columbus, OH, 2/21/02 12. “Longitudinal followup of Pseudomonas aeruginosa infection in young children with cystic fibrosis,” American Thoracic Society International Conference, Seattle, WA, May, 2003. 13. “What effect do anti-pseudomonal antibtiocs have on serial upper airway cutltues in infant with CF?” Workshop presentation at 2003 North American Cystic Fibrosis Foundation Annual Conference, Anaheim, October, 2003 14. “Dilemmas regarding lung transplant referral criteria,” Expert discussant, Physician Grand Rounds, 2003 North American Cystic Fibrosis Foundation Annual Conference, Anaheim, October, 2003 15. “Overview of published evidence on outcomes with early detection,” 2003 Newborn Screening for Cystic Fibrosis Meeting, sponsored by the National Center on Birth Defects 1. Margaret Rosenfeld, MD, MPH Page 10 and Developmental Disbilities at the Centers for Disease Control and the Cystic Fibrosis Foundation, Atlanta, November 20, 2003