Supplementary notes
The IGAP comprises 4 major groups studying the genetics of Alzheimer’s disease, the
Alzheimer Disease Genetics Consortium (ADGC), the neurology working group of the
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), the
European Initiative for Alzheimer Disease (EADI) and the Genetic and Environmental
Risk in Alzheimer's Disease (GERAD).
1. ADGC consortium
Regina M Carney1, Deborah C Mash2, Marilyn S Albert3, Roger L Albin4,5, Liana G
Apostolova6, Steven E Arnold8, Clinton T Baldwin8, Michael M Barmada9, Lisa L
Barnes10,11, Thomas G Beach12, Eileen H Bigio13, Thomas D Bird14, Bradley F Boeve15,
James D Bowen16, Adam Boxer17, James R Burk18, Nigel J Cairns19, Chuanhai Cao20,
Chris S Carlson21, Steven L Carroll22, Lori B Chibnik23,24, Helena C Chui25, David G
Clark26, Jason Corneveaux27, David G Cribbs28, Charles DeCarli29, Steven T DeKosky30,
F Yesim Demirci9, Malcolm Dick31, Dennis W Dickson32, Ranjan Duara33, Nilufer ErtekinTaner32,34, Kenneth B Fallon22, Martin R Farlow35, Steven Ferris36, Matthew P Frosch37,
Douglas R Galasko38, Mary Ganguli39, Marla Gearing40,41, Daniel H Geschwind42,
Bernardino Ghetti 43, Sid Gilman4, Jonathan D Glass44, Robert C Green45, John H
Growdon46, Ronald L Hamilton47, Chiao-Feng Lin48,Lindy E Harrell 26, Elizabeth Head49,
Lawrence S Honig50, Christine M Hulette51, Bradley T Hyman46, Gail P Jarvik52,53,
Gregory A Jicha54, Lee-Way Jin55, Anna Karydas17, John SK Kauwe56, Jeffrey A
Kaye57,58, Ronald Kim59, Edward H Koo38, Neil W Kowall60,61, Joel H Kramer62, Patricia
Kramer57,63, Frank M LaFerla64, James J Lah44, James B Leverenz65, Allan I Levey44, Ge
Li66, Andrew P Lieberman67, Constantine G Lyketsos68, Wendy J Mack69, Daniel C
Marson26, Frank Martiniuk70, Eliezer Masliah38,71, Wayne C McCormick72, Susan M
McCurry73, Andrew N McDavid21, Ann C McKee60,61, Marsel Mesulam74, Bruce L Miller17,
Carol A Miller75, Brian Kunkle76, Joshua W Miller55, John C Morris19,77, Jill R Murrell43,78,
John M Olichney29, Vernon S Pankratz80, Joseph E Parisi81,82, Elaine Peskind66, Tricia
A Thornton-Wells8315, Ronald C Petersen1583, Aimee Pierce28, Wayne W Poon31,
Huntington Potter84, Joseph F Quinn57, Ashok Raj84, Murray Raskind66, Eric M.
Reiman27,85,86, Barry Reisberg36,87, John M Ringman6, Erik D Roberson2648, Howard J
Rosen17, Roger N Rosenberg88, Mary Sano89, Andrew J Saykin43,90, Julie A
Schneider10,91, Lon S Schneider6,92, William W Seeley17, Amanda G Smith84, Joshua A
Sonnen65, Salvatore Spina43, Robert A Stern60, Rudolph E Tanzi46, John Q
Trojanowski93, Juan C Troncoso94, Vivianna M Van Deerlin93, Linda J Van Eldik95, Harry
V Vinters6,96, Jean Paul Vonsattel97, Sandra Weintraub74, Robert Green98, Kathleen A
Welsh-Bohmer18,99, Jennifer Williamson50, Randall L Woltjer100, Chang-En Yu72, Robert
Barber101, Adam C Naj102,103, Gyungah Jun104,105,106, Gary W Beecham1,107, Badri N
Vardarajan104, Otto Valladares48, Christiane Reitz108,109, Joseph D Buxbaum110,111,112,
Clinton Baldwin104, Najaf Amin113, Philip L De Jager114,115, Denis Evans116, Matthew J
Huentelman117, M Ilyas Kamboh118,119, Amanda J Myers120, Ekaterina Rogaeva121, Peter
St George-Hyslop121,122, Lei Yu123, John R Gilbert1,107, Hakon Hakonarson124, Kara L
Hamilton-Nelson1, Kelley M Faber125, Laura B Cantwell48, Deborah Blacker126,127, David
A Bennett123,128, Thomas J Montine129, Tatiana M Foroud125, Walter A Kukull130, Kathryn
L Lunetta106, John SK Kauwe131, Eric Boerwinkle132,133, Eden R Martin1,107, Li-San
Wang48.
1.
The John P. Hussman Institute for Human Genomics, University of Miami, Miami,
FL, 33124, USA
2.
Department of Neurology, University of Miami, Miami, FL, 33124, USA
3.
Department of Neurology, Johns Hopkins University, Baltimore, MD, 21218, USA
4.
Department of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA
5.
Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor
Healthcare System (VAAAHS), Ann Arbor, MI, 48109, USA
6.
Department of Neurology, University of California Los Angeles
, Los
Angeles, CA, 94607, USA
7.
Department of Psychiatry, University of Pennsylvania Perelman School of
Medicine, Philadelphia, PA, 19104, USA
8.
Department of Medicine (Biomedical Genetics), Boston University School of
Medicine, Boston, MA, 02215, USA
9.
Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, 15213,
USA
10.
Department of Neurological Sciences, Rush University Medical Center, Chicago,
IL, 60612, USA
11.
Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL,
60612, USA
12.
Civil Laboratory for Neuropathology, Banner Sun Health Research Institute,
Phoenix, AZ, 85351, USA
13.
Department of Pathology, Northwestern University, Chicago, IL, 60208, USA
14.
Department of Neurology, University of Washington, Seattle, WA, 98195, USA
15.
Department of Neurology, Mayo Clinic, Rochester, MN, 55902, USA
16.
Swedish Medical Center, Seattle, WA, 98195, USA
17.
Department of Neurology, University of California San Francisco, San Francisco,
CA, 94122, USA
18.
Department of Medicine, Duke University, Durham, NC, 27710, USA
19.
Department of Pathology and Immunology, Washington University, St. Louis, MO,
63130, USA
20.
USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, CA,
33620, USA
21.
Fred Hutchinson Cancer Research Center, Seattle, WA, 98195, USA
22.
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL,
35294, USA
23.
Program in Translational NeuroPsychiatric Genomics, Institute for the
Neurosciences, Department of Neurology & Psychiatry, Bringham and Women's
Hospital, Harvard Medical School, Boston, MA, 02215, USA
24.
Program in Medical and Population Genetics, Broad Institute, Boston, MA, 02215,
USA
25.
Department of Neurology, University of Southern California, Los Angeles, CA,
94607, USA
26.
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL,
35294, USA
27.
Neurogenomics Division, Translational Genomics Research Institute, Phoenix,
AZ, 85004, USA
28.
Department of Neurology, University of California Irvine, Irvine, CA, 92617, USA
29.
Department of Neurology, University of California Davis, Sacramento, CA, 95616,
USA
30.
University of Virginia School of Medicine, Charlottesville, VA, 22903, USA
31.
Institute for Memory Impairments and Neurological Disorders, University of
California Irvine, Irvine, CA, 92617, USA
32.
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 55902, USA
33.
Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai
Medical Center, Miami Beach, FL, 10029, USA
34.
Department of Neurology, Mayo Clinic, Jacksonville, FL, 55902, USA
35.
Department of Neurology, Indiana University
36.
Department of Psychiatry, New York University, New York, NY, 10027, USA
37.
C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital,
, Indianapolis, IN, 46202, USA
Charlestown, MA, 02114, USA
38.
Department of Neurosciences, University of California San Diego, La Jolla, CA,
92093, USA
39.
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15213, USA
40.
Department of Pathology and Laboratory Medicine, Emory University, Atlanta,
GA, 30329, USA
41.
Emory Alzheimer's Disease Center, Emory University, Atlanta, GA, 30329, USA
42.
Neurogenetics Program, University of California Los Angeles , Los Angeles, CA,
94607, USA
43.
Department of Pathology and Laboratory Medicine, Indiana University,
Indianapolis, IN, 46202, USA
44.
Department of Neurology, Emory University, Atlanta, GA, 30329, USA
45.
Division of Genetics, Department of Medicine and Partners Center for
Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical
School, Boston, MA, 02215
46.
, USA
Department of Neurology, Massachusetts General Hospital/Harvard Medical
School, Boston, MA, 02215, USA
47.
Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh,
PA, 15213, USA
48. Department of Pathology and Laboratory Medicine, University of Pennsylvania
Perelman School of Medicine, Philadelphia, PA, 19104, USA
49.
Sanders-Brown Center on Aging, Department of Molecular and Biomedical
Pharmacology, University of Kentucky, Lexington, KY, 40506, USA
50.
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of
Neurology, Columbia University, New York, NY, 10027, USA
51.
Department of Pathology, Duke University, Durham, NC, 27710, USA
52.
Department of Genome Sciences, University of Washington, Seattle, WA, 98195,
USA
53.
Department of Medicine (Medical Genetics), University of Washington, Seattle,
WA, 98195, USA
54.
Sanders-Brown Center on Aging, Department Neurology, University of Kentucky,
Lexington, KY, 40506, USA
55.
Department of Pathology and Laboratory Medicine, University of California Davis,
Sacramento, CA, 95616, USA
56.
Department of Biology, Brigham Young University, Provo, UT
02215, USA
57.
Department of Neurology, Oregon Health & Science University, Portland, OR,
97239, USA
58.
Department of Neurology, Portland Veterans Affairs Medical Center, Portland,
OR, 97239, USA
59.
Department of Pathology and Laboratory Medicine, University of California Irvine,
Irvine, CA, 92617, USA
60.
Department of Neurology, Boston University School of Medicine, Boston, MA,
02215, USA
61.
Department of Pathology, Boston University School of Medicine, Boston, MA,
02215, USA
62.
Department of Neuropsychology, University of California San Francisco, San
Francisco, CA, 94122, USA
63.
Department of Molecular & Medical Genetics, Oregon Health & Science
University, Portland, OR, 97239, USA
64.
Department of Neurobiology and Behavior, University of California Irvine, Irvine,
CA, 92617, USA
65.
Department of Pathology, University of Washington, Seattle, WA, 98195, USA
66.
Department of Psychiatry and Behavioral Sciences, University of Washington
, Seattle, WA, 98195, USA
67.
Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA
68.
Department of Psychiatry, Johns Hopkins University, Baltimore, MD, 21218, USA
69.
Department of Preventive Medicine, University of Southern California
Angeles, CA, 94607, USA
, Los
70.
Department of Medicine - Pulmonary, New York University, New York, NY,
10027, USA
71.
Department of Pathology, University of California San Diego, La Jolla, CA, 92093,
USA
72.
Department of Medicine, University of Washington, Seattle, WA, 98195, USA
73.
School of Nursing Northwest Research Group on Aging, University of
Washington, Seattle, WA, 98195, USA
74.
Cognitive Neurology and Alzheimer's Disease Center, Northwestern University,
Chicago, IL, 60208, USA
75.
Department of Pathology, University of Southern California, Los Angeles, CA,
94607, USA
76. Cardiovascular Health Research Unit, Department of Medicine, University of
Washington, Seattle, WA, 98101, USA
77.
Department of Neurology, Washington University, St. Louis, MO, 98101, USA
78.
Department of Medical and Molecular Genetics, Indiana University, Indianapolis,
IN, 46202, USA
80.
Department of Biostatistics, Mayo Clinic, Rochester, MN, 55902, USA
81.
Department of Anatomic Pathology, Mayo Clinic, Mayo Clinic, Rochester, MN,
55902, USA
82.
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN,
55902, USA
83. Department of Molecular Physiology and Biophysics, Vanderbilt University,
Nashville, TN, 37212, USA
84.
USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL,
33613 , USA
85.
Arizona Alzheimer’s Consortium, Department of Psychiatry, University of Arizona,
Phoenix, AZ, 85004, USA
86.
Banner Alzheimer's Institute,
Phoenix, AZ, 85004, USA
87.
Alzheimer's Disease Center, New York University, New York, NY, 10027, USA
88.
Department of Neurology, University of Texas Southwestern, Dallas, TX, 75390,
USA
89.
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY,
10027, USA
90.
Department of Radiology and Imaging Sciences, Indiana University, Indianapolis,
IN, 46202, USA
91.
Department of Pathology (Neuropathology), Rush University Medical Center,
Chicago, IL, 60208, USA
92.
Department of Psychiatry, University of Southern California, Los Angeles, CA,
94607, USA
93.
Department of Pathology and Laboratory Medicine, University of Pennsylvania,
Perelman School of Medicine, Philadelphia, PA, 19104, USA
94.
Department of Pathology, Johns Hopkins University, Baltimore, MD, 21218, USA
95.
Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology,
University of Kentucky, Lexington, KY, 40506, USA
96.
Department of Pathology & Laboratory Medicine, University of California Los
Angeles, Los Angeles, CA, 94607, USA
97.
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of
Pathology, Columbia University, New York, NY, 10027, USA
98. Division of Genetics, Department of Medicine and Partners Center for Personalized
Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School,
USA.
99.
Department of Psychiatry & Behavioral Sciences, Duke University, Durham, NC,
27710, USA
100.
Department of Pathology, Oregon Health & Science University, Portland, OR,
97239, USA
101.
Department of Pharmacology and Neuroscience, University of North Texas
Health Science Center, Fort Worth, TX, 76102, USA
102. Department of Biostatistics Epidemiology, Perelman School of Medicine, University
of Pennsylvania, Philadelphia, PA 19104, USA
103. Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine,
University of Pennsylvania, Philadelphia, PA 19104, USA
104. Department of Medicine (Biomedical Genetics), Boston University School of Public
Health, Boston, MA, 02218, USA
105. Department of Ophthalmology, Boston University School of Public Health, Boston,
MA, 02215, USA
106. Department of Biostatistics, Boston University School of Public Health, Boston, MA,
02118, USA
107. Dr. John T. Macdonald Foundation Department of Human Genetics, University of
Miami, Miami, FL, 33124, USA
108. Taub Institute on Alzheimer's Disease and the Aging Brain, Department of
Neurology, Columbia University New York, NY, 10027, USA
109. Gertrude H. Sergievsky Center, Department of Neurology, Columbia University,
New York, NY, 10027, USA
110. Department of Neuroscience, Mount Sinai School of Medicine, New York, NY
10027, USA
111. Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10027,
USA
112. Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine,
New York, NY 10027, USA
113. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam,
3015 CE the Netherlands
114. Program in Translational NeuroPsychiatric Genomics, Institute for the
Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's
Hospital and Harvard Medical School, Boston, MA 02215 USA
115. Program in Medical and Population Genetics, Broad Institute, Boston, MA 02215
USA
116. Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University
Medical Center, Chicago, IL 60612, USA
117. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ
85004, USA
118. Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15213,
USA
119. Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA
15213, USA
120.
Department of Psychiatry and Behavioral Sciences, Miller School of Medicine,
University of Miami, Miami, FL 33124, USA
121. Tanz Centre for Research in Neurodegenerative Disease, University of Toronto,
Toronto, ON M5S 1A1, Canada
122. Cambridge Institute for Medical Research and Department of Clinical
Neurosciences, University of Cambridge, Cambridge
CB2 1TN, UK
123. Department of Neurological Sciences, Rush University Medical Center, Chicago, IL
60612, USA
124. Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA
19104, USA
125. Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN
46202, USA
126. Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115,
USA
127. Department of Psychiatry, Massachusetts General Hospital/Harvard Medical
School, Boston, MA 02115, USA
128. Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL
60612, USA
129. Department of Pathology, University of Washington, Seattle, WA 98195, USA
130. Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
131. Department of Biology, Brigham Young University, Provo, UT, 84602, USA
132. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX
77030, USA
133. Human Genetics Center and Div. of Epidemiology, University of Texas Health
Sciences Center at Houston, Houston, TX 77030, USA
2. CHARGE consortium
Rhoda Au1, Philip A Wolf1, Alexa Beiser2, Stephanie Debette1,3, Qiong Yang2, Galit
Weinstein1, Andrew D Johnson4, Jing Wang2, Andre G Uiterlinden5,6,7, Fernando
Rivadeneira5, Peter J Koudstaal8, William T Longstreth Jr
9,10,11,
James T Becker12,
Lewis H Kuller13, Thomas Lumley14, Kenneth Rice15, Melissa Garcia16, Thor Aspelund17,
Josef
JM
Marksteiner18,
Peter
Dal-Bianco19,
Anna
Maria
Töglhofer20,
Paul
Freudenberger20, Gerhard Ransmayr21, Thomas Benke22, Anna M Toeglhofer20, Jan
Bressler23, Monique MB Breteler24, Myriam Fornage25, Reinhold Schmidt26, Reposo
Ramírez-Lorca27, Antonio González-Perez27, Carla A Ibrahim-Verbaas28, Anita L
DeStefano29, Tamara B Harris30, Albert V Smith31,32, M Arfan Ikram33,34,Helena
Schmidt20, Seung-Hoan Choi29, Annette L Fitzpatrick30,35, Paul K Crane36, Vilmundur
Gudnason31,32, Oscar L Lopez37, Francisco J Morón27, Gudny Eiriksdottir32, Eric B
Larson36,38, Debby W Tsuang39, Duane Beekly40, Palmi V Jonsson31,41, Thomas H
Mosley Jr42, Renee FAG de Bruijn43, Jerome I Rotter44, Michael A Nalls45, Albert
Hofman33,34, Bruce M Psaty30,46.
1. Department of Neurology, Boston University School of Medicine, Boston, MA 2118,
USA
2. Department of Biostatistics, Boston University School of Public Health, Boston, MA
2118, USA
3. UMR744 Inserm, Lille, France
4. NHLBI Center for Cardiovascular Genomics, the Framingham Study, Framingham,
MA 1702, USA
5. Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam,
3000 CA, the Netherlands (Uiterlinden)
6. Department of Epidemiology, Erasmus University Medical Center, PO Box 2040,
3000 CA Rotterdam, The Netherlands (Uiterlinden)
7. Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands
(Uiterlinden)
8. Department of Neurology, Erasmus MC University Medical Center, Rotterdam 3000
CA, the Netherlands
9. Cardiovascular Health Research Unit, Department of Medicine, University of
Washington, Seattle, WA 98101, USA
10.
Department of Epidemiology, University of Washington, Seattle, WA 98101, USA
11.
Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101,
USA
12.
The Departments of Neurology and Psychiatry, University of Pittsburgh School of
Medicine, Pittsburgh, PA 15213, USA
13.
Departments of Medicine and Epidemiology, University of Pittsburgh School of
Medicine, Pittsburgh, PA 15213, USA
14.
Department of Statistics, University of Auckland, Auckland, New Zealand.
15.
Department of Biostatistics, University of Washington, School of Medicine,
Seattle, WA 98101, USA
16.
Laboratory of Epidemiology, Demography and Biometry, National Institute on
Aging, Bethesda, MD, 20892, USA
17.
The Icelandic Heart Association, Landspitali-University Hospital, Reykjavik,
Iceland
18.
Department of Psychiatry and Psychotherapy, General Hospital, Hall, 6060,
Austria
19.
Department of Neurology, Medical University of Vienna, Vienna, 1090, Austria
20.
Institute for Molecular Biology and Biochemistry, Medical University of Graz,
Graz, 8010, Austria
21.
Department of Neurology and Psychiatry,General Hospital Linz, Austria, Linz,
4020, Austria
22 Clinic of Neurology, Medical University Innsbruck, Innsbruck, 6020, Austria
23.
School of Public Health, University of Texas Health Sciences Center at Houston,
Houston, TX 77030, USA
24.
German Center for Neurodegenerative diseases (DZNE), Bonn, 53175, Germany
25.
Institute of Molecular Medicine and School of Public Health Division of
Epidemiology Human Genetics and Environmental Sciences, University of Texas
Health Sciences Center at Houston, Houston, TX 77030, USA
26.
Department of Neurology, Medical University Graz, Graz, Austria
27.
Departamento de Genómica Estructural . Neocodex, Sevilla, 8029, Spain
28.
Department of Epidemiology, Clinical Genetics and Neurology, Erasmus MC
University Medical Center, Rotterdam, 3015 CE, the Netherlands
29.
Department of Biostatistics, Boston University School of Public Health, Boston,
MA, 02118, USA
30.
Cardiovascular Health Research Unit, Department of Medicine, University of
Washington, Seattle, WA, 98101, USA
31.
University of Iceland, Faculty of Medicine, Reykjavik, Iceland
32.
Icelandic Heart Association, Kopavogur, Iceland
33.
Departments of Epidemiology, Neurology and Radiology, Erasmus MC University
Medical Center, Rotterdam, 3015 CE, the Netherlands
34.
Netherlands Consortium for Healthy Aging, Leiden, The Netherlands
35.
Department of Epidemiology and Global Health, University of Washington,
Seattle, WA 98101, USA
36.
Department of Medicine, University of Washington, Seattle, WA 98195, USA
37.
Departments of Neurology, University of Pittsburgh School of Medicine,
Pittsburgh, PA 15213 USA
38.
Group Health Research Institute, Group Health, Seattle, WA 98195, USA
39.
Department of Psychiatry and Behavioral Sciences, University of Washington,
Seattle, WA 98195, USA
40.
National Alzheimer's Coordinating Center, University of Washington, Seattle, WA
98195, USA
41.
Landspitali University Hospital, Reykjavik, Iceland
42.
Department of Medicine (Geriatrics), University of Mississippi Medical Center,
Jackson, MS 39216 USA
43.
Departments of Neurology and Epidemiology, Erasmus MC University Medical
Center, Rotterdam, 3015 CE, the Netherlands
44.
Medical Genetics
Institute, Cedars-Sinai Medical Center, Los Angeles, CA
90048, USA
45.
Laboratory of Neurogenetics, Intramural Research Program, National Institute on
Aging, Bethesda, MD 20892, USA
46.
Group Health Research Institute, Group Health Cooperative, Seattle, WA. 98101,
USA
3. EADI consortium
Jean-Charles Lambert1,2,3, Benjamin Grenier-Boley1,2,3, Florence Pasquier2,4, Vincent
Deramecourt2,4, Nathalie Fiévet1,3,, Diana Zelenika5, Yoichiro Kamatani6, Marie-Thérèse
Bihoreau5, Mark Lathrop5,6,7, Olivier Hanon8, Dominique Campion9, Claudine Berr10, Luc
Letenneur11, Kristel Sleegers12,13, Lina Keller14, Pascale Barberger-Gateau11, Carole
Dufouil11, David Wallon9, Jordi Clarimon15,16, Alberti Lleo15,16, Paola Bossù17, Gianfranco
Spalletta17, Sandro Sorbi18,19, Florentino Sanchez Garcia20, Maria Candida Deniz
Naranjo20, Paolo Bosco21, Daniela Galimberti22, Michelangelo Mancuso23, Patrizia
Mecocci24, Maria Del Zompo25, Alberto Pilotto26, Maria Bullido27,28,29, Francesco Panza30,
Paolo Caffarra31,32, Benedetta Nacmias18,19, Lars Lannfelt33, Martin Ingelsson33, Victoria
Alvarez34, Cristina Razquin35, Pau Pastor35,36, Ignacio Mateo37, Eliecer Coto34, Onofre
Combarros37, Hilkka Soininen38,39, Laura Fratiglioni14,40, Karolien Bettens12,13, Alexis
Brice41,42, Didier Hannequin9, Karen Ritchie10,43, Mikko Hiltunen38,39, Jean-François
Dartigues11,44, Christophe Tzourio45, Caroline Graff40,46, Annick Alpérovitch47, Anne
Boland5, Marc Delépine5, Bruno Dubois48, Emmanuelle Duron49, Jacques Epelbaum50,
Caroline Van Cauwenberghe12,51, Sebastiaan Engelborghs51,52, Rik Vandenberghe53,54,
Peter P. De Deyn51,52, Raffaele Ferri55, Carmelo Romano55, Carlo Caltagirone56, Maria
Donata Orfei56, Antonio Ciaramella56, Elio Scarpini57,58, Chiara Fenoglio57,58, Gabriele
Siciliano23, Ubaldo Bonuccelli23, Silvia Bagnoli19,59, Laura Bracco19,59, Valentina
Bessi19,59, Roberta Cecchetti60,61, Patrizia Bastiani60,61, Alessio Squassina62, Davide
Seripa63, Ana Frank-García28,29,64, Isabel Sastre,28,29,65, Rafael Blesa16,66, Daniel
Alcolea16,66, Marc Suárez-Calvet16,66, Pascual Sánchez-Juan37, Carmen Muñoz
Fernandez67, Yolanda Aladro Benito67, Håkan Thonberg68, Charlotte Forsell46, Lena
Lilius46, Anne Kinhult-Ståhlbom68, Vilmantas Giedraitis33, Lena Kilander33, Rose Marie
Brundin33, Letizia Concari69,70, Seppo Helisalmi39,71, Anne Maria Koivisto39,71, Annakaisa
Haapasalo39,71, Vincenzo Solfrizzi72, Vincenza Frisardi73, Jurg Ott74, Christine Van
Broeckhoven12,13, Philippe Amouyel1,2,3,4,75.
1.
Inserm, U744, Lille, 59000, France
2.
Université Lille 2, Lille, 59000, France
3.
Institut Pasteur de Lille, Lille, 59000, France
4.
CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, 59000, France
5.
Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie
Atomique, Evry, France
6.
Fondation Jean Dausset, CEPH, Paris, France
7.
McGill University and Génome Québec Innovation Centre, Montreal, Canada
8.
University Paris Descartes, Sorbonne Paris V; Broca Hospital, Geriatrics
department; Paris, France
9.
CNR-MAJ; Inserm, U1079; Rouen University Hospital; 76031 France, Rouen,
France
10. Inserm, U1061; Faculty of Medicine; Hôpital La Colombière; Montpellier, France
11. Inserm, U897; Victor Segalen University; F-33076, Bordeaux, France
12. Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB,
Antwerp, Belgium
13. Department of Molecular Genetics, VIB, Laboratory of Neurogenetics, Institute
Born-Bunge, University of Antwerp, Antwerp, Belgium
14. Aging Reasearch Center, Dept Neurobiology, Care Sciences and Society,
Karolinska Institutet and Stockholm University, Stockholm, Sweden
15. Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de
Barcelona, Barcelona, Spain.
16. Center for Networker Biomedical Research in Neurodegenerative Diseases
(CIBERNED), Barcelona, Spain.
17. Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy
18. NEUROFARBA Department of Neuroscience, Psychology, Drug Research and
Child Health, University of Florence, Florence, Italy
19. Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of
Florence, Florence, Italy
20. Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran
Canaria, Spain
21. IRCCS Associazione Oasi Maria SS, Troina, Italy
22. University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan,
Italy
23. Neurological Clinic, University of Pisa, Italy
24. Section of Gerontology and Geriatrics, Department of Clinical and Experimental
Medicine, University of Perugia, Perugia, Italy
25. Section of Neuroscience and Clinical Pharmacology, Department of Biomedical
Sciences, University of Cagliari, Cagliari, Italy
26. Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della
Sofferenza, San Giovanni Rotondo (FG), Italy
27. Centro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid, Spain
28. Centro
de
Investigación
Biomédica
en
Red
sobre
Enfermedades
Neurodegenerativas (CIBERNED), Madrid, Spain
29. Instituto de Investigación Sanitaria “Hospital la Paz” (IdIPaz), Madrid, Spain
30. Departement of Geriatrics,Center for Aging Brain ,University of Bari, Bari, Italy
31. Department of Neuroscience-University of Parma, Parma, Italy
32. Center for Cognitive Disorders AUSL, Parma, Italy
33. Dept. of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden
34. Genetica molecular-Huca-Oviedo, Oviedo, Spain
35. Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical
Research, University of Navarra School of Medicine, Pamplona, Spain
36. CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades
Neurodegenerativas, Instituto de Salud Carlos III, Spain
37. Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital
(University of Cantabria and IFIMAV), Santander, Spain
38. Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio,
70211 Finland
39. Department of Neurology, Kuopio University Hospital, FIN-70211 Kuopio, Finland
40. Dept Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, S14186 Stockholm
41. INSERM UMR_S975-CNRS UMR 7225, Université Pierre et Marie Curie, Centre
de recherche de l'Institut du Cerveau et de la Moëlle épinière-CRICM, Hôpital de la
Salpêtrière, Paris France
42. AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France
43. Imperial College, London
44. Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de
Bordeaux, Bordeaux, France
45. Inserm, U708; Victor Segalen University; F-33076, Bordeaux, France
46. Karolinska Institutet, Dept Neurobiology, Care Sciences and Society, KIADRC,
Novum floor 5, S14186 Stockholm, Sweden
47.
Inserm U708, Victor Segalen University, F-33076, Bordeaux, France
48.
IM2A - CRicm-UMRS975, AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France
49.
CMRR Paris Sud Ile-de-France, service de gériatrie, Hôpital Broca, 54-56 rue
Pascal, 75013 Paris
50.
UMR 894 Inserm, Psychiatry and Neurosciences Center, Paris, France
51.
Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
52.
Department of Neurology and Memory Clinic, Hospital Network Antwerp,
Antwerp, Belgium
53.
Laboratory for Cognitive Neurology, Department of Neurology, University of
Leuven, Leuven, Belgium
54.
Department of Neurology and Memory Clinic, University Hospitals Leuven
Gasthuisberg, Leuven, Belgium
55.
IRCCS Associazione Oasi Maria SS, Troina, Italy
56.
Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma ,Italy
57.
University of Milan, Milan, Italy
58.
Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy
59.
Department of Neurological and Psychiatric Sciences, University of Florence,
Florence, Italy
60.
Section of Gerontology and Geriatrics, Department of Clinical and Experimental
Medicine Perugia, Italy
61.
University of Perugia, Perugia, Italy
62.
Section of Neuroscience and Clinical Pharmacology, Department of Biomedical
Science, University of Cagliari, Cagliari, Italy
63.
Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della
Sofferenza, San Giovanni Rotondo (FG), Italy
64.
Neurology Service; Hospital Universitario La Paz (UAM), Madrid, Spain
65.
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain
66.
Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma
de Barcelona. Barcelona, Spain.
67.
Department of Neurology, Hospital Universitario Dr. Negrin, Las Palmas de Gran
Canaria, Spain
68.
Dept Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge,
S-14186 Stockholm, Sweden
69.
Department of Neuroscience-University of Parma-Italy, Parma, Italy
70.
Center for Cognitive Disorders AUSL, Parma, Italy
71.
Institute of Clinical Medicine - Neurology, University of Eastern Finland, FIN-
70211, Kuopio, Finland
72.
Department of Geriatrics, Center for Aging Brain ,University of Bari, Bari, Italy
73.
Department of Neurosciences and Sensory Organs, Aldo Moro University of Bari,
Bari, Italy
74.
Laboratory of Statistical Genetics, The Rockfeller University, 1230 York Avenue,
New York, NY, 10065, USA
75.
Centre Hospitalier Régional Universitaire de Lille, Lille, 59000, France.
4. GERAD consortium
Jade Chapman1, Alexandra Stretton1, Angharad Morgan1, Patrick G Kehoe2,
Christopher Medway3, Jenny Lord3, James Turton3, Nigel M Hooper4, Emma Vardy5,
Jason D Warren6, Jonathan M Schott6, James Uphill7, Natalie Ryan6, Martin Rossor6,7,
Yoav Ben-Shlomo8, Daniilidou Makrina9, Olymbia Gkatzima9, Michelle Lupton10, Maria
Koutroumani9, Despoina Avramidou9, Antonia Germanou9, Dan Rujescu11, Steffi RiedelHeller12, Martin Dichgans13, Reiner Heun14, Heike Kölsch14, Britta Schürmann14,
Christine Herold15, Dmitriy Drichel15, Per Hoffmann16, Johannes Kornhuber17, Wei Gu18,
Thomas Feulner18, Hendrik van den Bussche19, Brian Lawlor20, Aoibhinn Lynch20, David
Mann21, David A Smith22, Donald Warden22, Gordon Wilcock22, Isabella Heuser23, Jens
Wiltfang24, Lutz Frölich25, Michael Hüll26, Kevin Mayo27, Gill Livingston28, Nicholas J
Bass28, Hugh Gurling28, Andrew McQuillin28, Rhian Gwilliam29, Panagiotis Deloukas29,
Ammar Al-Chalabi30, Christopher E Shaw30, Andrew B Singleton31, Rita Guerreiro31,
Karl-Heinz Jöckel32, Norman Klopp33, H-Erich Wichmann33, Dennis W Dickson34, Neill R
Graff-Radford34, Li Ma34, Gina Bisceglio34, Elizabeth Fisher35, Nick Warner36, Stuart
Pickering-Brown37, Giancarlo Russo38, Nicola Jones1, Charlene Thomas1, Melanie L
Dunstan1, Paul Hollingworth1, Carlos Cruchaga39, David Craig40, Janet A Johnston40,
Simon Lovestone41, David C Rubinsztein42, Alison M Goate39, Michael Gill43, Kristelle
Brown3, Bernadette McGuinness40, Stephen Todd40, Seth Love2, John Gallacher44,
Anthony Bayer44, Magda Tsolaki45, Petra Proitsi41, John Collinge7, Nick C Fox6, John
Hardy46, Robert Clarke47, Carol Brayne48, Fiona Matthews49, Susanne Moebus50, Harald
Hampel51,52, Manuel Mayhaus53, Sabrina Pichler53, Minerva M Carrasquillo54, Fanggeng
Zou54, Steven G Younkin54, Wei Gu55, Michael J Owen1, Michael C O'Donovan1, Simon
Mead7,
Peter
Passmore40,
Kevin
Morgan3,
John
F
Powell41,
Matthias
Riemenschneider55, Clive Holmes56,Lesley Jones1, Peter A Holmans1, Valentina
Moskvina1, Julie Williams1.
1.
Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for
Neuropsychiatric Genetics & Genomics, Cardiff University, UK
2.
University of Bristol Institute of Clinical Neurosciences, School of Clinical
Sciences, Frenchay Hospital, Bristol, UK
3.
Institute of Genetics, Queen's Medical Centre, University of Nottingham, UK.
4.
Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, LIGHT
Laboratories, University of Leeds, Leeds, UK.
5.
Institute for Ageing and Health, Newcastle University, Biomedical Research
Building, Campus for Ageing and Vitality, Newcastle upon Tyne.
6.
Dementia Research Center, Department of Neurodegenerative Disease, UCL
Institute of Neurology, London, UK.
7.
MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of
Neurology, London, UK.
8.
School of Social and Community Medicine, University of Bristol, Bristol, UK
9.
Aristotle University of Thessaloniki, Despere 3, Thessaloniki, 54621, Greece
10.
King's College London, Institute of Psychiatry, Department of Neuroscience, De
Crespigny Park, Denmark Hill, London
11. Department of Psychiatry, University of Munich, Munich and University of Halle,
Halle, Germany
12.
Institute of Social Medicine, Occupational Health and Public Health, University of
Leipzig, Leipzig, Germany
13.
Institute for Stroke and Dementia Research, Klinikum der Universität München,
Munich, Germany and German Center for Neurodegenerative Diseases (DZNE,
Munich), Munich, Germany
14.
Department of Psychiatry and Psychotherapy, University of Bonn, Germany
15.
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE, Bonn), Bonn,
Germany
16.
Division of Medical Genetics, University Hospital and Department of Biomedicine,
University of Basel, Basel, Switzerland
17.
Department of Psychiatry, University of Erlangen, Nürnberg, Germany
18.
Dept. Of Psychaitry, University Hospital, Saarland, Germany
19.
Institute of Primary Medical Care, University Medical Center Hamburg-Eppendorf,
Germany
20.
Mercer's Institute for Research on Aging, St. James Hospital and Trinity College,
Dublin, Ireland
21.
Clinical Neuroscience Research Group, Greater Manchester Neurosciences
Centre, University of Manchester, Salford, UK
22.
Oxford Project to Investigate Memory and Ageing (OPTIMA), University of
Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, UK
23.
Department of Psychiatry, Charité, Berlin, Germany
24.
LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, University
Duisburg-Essen, Germany
25.
Central Institute of Mental Health, Medical Faculty Mannheim, University of
Heidelberg, Germany.
26.
Department of Psychiatry, University of Frankfurt am Main, Frankfurt am Main,
Germany
27.
Departments of Psychiatry, Neurology and Genetics, Washington University
School of Medicine, St Louis, MO 63110, US.
28.
Department of Mental Health Sciences, University College London, UK.
29.
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton,
Cambridge, UK.
30.
MRC
Centre
for
Neurodegeneration
Research,
Department
of
Clinical
Neuroscience, King’s College London, Institute of Psychiatry, London, SE5 8AF, UK.
31.
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of
Health, Bethesda, MD, 20892, USA.
32.
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital
of Essen, University Duisburg-Essen, Hufelandstr. 55, D-45147 Essen, Germany.
33.
Institute of Epidemiology, Helmholtz Zentrum München, German Research
Center for Environmental Health, Neuherberg, Germany
34.
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, 32224, USA
35.
Department of Neurodegenerative Disease, UCL Institute of Neurology, London.
36.
Somerset Partnership NHS Trust, Somerset, UK
37.
Institute of Brain, Behaviour and Mental Health, Faculty of Human and Medical
Sciences, University of Manchester, Manchester UK
38. Functional Genomics Center Zurich, ETH/University of Zurich, Switzerland
39. Department of Psychiatry and Hope Center Program on Protein Aggregation and
Neurodegeneration, Washington University School of Medicine, St. Louis, MO
63110, USA
40. Ageing Group, Centre for Public Health, School of Medicine, Dentistry and
Biomedical Sciences, Queen's University Belfast, UK
41. King's College London, Institute of Psychiatry, Department of Neuroscience, De
Crespigny Park, Denmark Hill, London
42. Cambridge Institute for Medical Research, University of Cambridge, Cambridge,
UK
43. Mercer's Institute for Research on Aging, St. James Hospital and Trinity College,
Dublin, Ireland.
44. Institute of Primary Care and Public Health, Cardiff University, Neuadd
Meirionnydd, University Hospital of Wales, Heath Park, Cardiff UK
45. Aristotle University of Thessaloniki, Despere 3, Thessaloniki, 54621, Greece
46. Department of Molecular Neuroscience and Reta Lilla Weston Laboratories,
Institute of Neurology, London, UK.
47. Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of
Oxford, Oxford, UK
48. Institute of Public Health, University of Cambridge, Cambridge, UK
49. MRC Biostatistics Unit, Cambridge, UK
50. Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology,
University Hospital Essen, University Duisburg-Essen, Essen, Germany
51. Department of Psychiatry, University Hospital, Saarland
52. Department of Psychiatry, University of Frankfurt am Main, Frankfurt am Main,
Germany (H.H.)
53. Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany
54. Department of Neuroscience, Mayo Clinic, Jacksonville Florida 32224
55. Department of Psychiatry, University Hospital, Saarland
56. Division of Clinical Neurosciences, School of Medicine, University of Southampton,
Southampton, UK