Pathogenesis of Bacteria, Viruses and Eukaryotic Parasites
Microbiology and Immunology 210 (Winter 2003)
Monday and Wednesday 2:15-4:05pm, Friday 2:15-3:05pm, Fairchild Science Building D300
Peter Sarnow, Fairchild Science Building D309b, 8-7076
TAs: Mary Brinig and Marianne Campbell
BASIC BIOLOGY
1. Wed. Jan. 8
Introduction to bacterial pathogenicity (Falkow)
2. Fri. Jan.10
Introduction to fundamental virology: properties of genomes
and translation schemes (Sarnow)
3. Mon. Jan.13
Introduction to eukaryotic parasites: diversity in form and
function (Boothroyd)
ENTRY MECHANISMS
4. Wed. Jan.15
Uptake of viruses (Mocarski)
5. Fri. Jan.17
Microbial entry into host cells: invasion factors, integrin receptors (Relman)
6. Mon. Jan.20
Holiday
7. Wed. Jan.22
Invasion of host cells by eukaryotic parasites (Boothroyd)
GENE EXPRESSION
8. Fri. Jan.24
Bacterial gene expression in biofilms and in response to environment (Matin)
9. Mon. Jan.27
Regulation of bacterial virulence-associated genes and virulence-associated
secretory and assembly pathways (Relman)
10. Wed. Jan.29
Gene expression in parasites: polycistronic transcription,
trans-splicing and RNA editing (Boothroyd)
11. Fri. Jan.31
Lytic infectious cycles (Sarnow)
12. Mon. Feb. 3
Latent viral infectious cycles (Mocarski)
13. Wed. Feb. 5
Retroviral gene expression (Nolan)
14. Fri. Feb. 7
Use of retroviruses in gene therapy (Blau)
HOST PATHOGEN INTERACTIONS
15. Mon. Feb. 10
Bacterial pathogen-plant cell interactions (Mudgett)
16. Wed. Feb. 12
Bacterial life within the vacuole and within the cytoplasm of
the host cell (Theriot)
17. Fri. Feb. 14
Plasmodium-host interactions (Schneider)
18. Mon. Feb. 17
holiday
19. Wed. Feb.19
Subversion of host pathways by viruses (Sarnow)
20. Fri. Feb. 21
Pseudomonas-host interactions (Tan)
21. Mon. Feb. 24
Structural issues in host-pathogen interactions (Garcia)
22. Wed. Feb. 26
TA-lectures
23. Fri. Feb. 28
Recruitment weekend
EVOLUTION
24. Mon. Mar. 3
Viral evolution (Kirkegaard)
25. Wed. Mar. 5
Persistent bacterial infection (Falkow)
HOST IMMUNE RESPONSES
26. Fri. Mar. 7
Host immune response to viral infection-viral vaccines (Arvin)
27. Mon. Mar. 10
Antigentic variation and evolution in parasites (Boothroyd)
28. Wed. Mar.12
Host immune responses to parasites (Schneider)
29. Fri. Mar. 14
Antibiotic resistance in bacteria (Theriot)
EXAM WEEK
Reference Texts:
Fields, Virology and Fundamental Virology, 1995 editions. Raven Press
Salyers, Bacterial Pathogenesis - A molecular Approach, 1994. ASM Press.
Flint et al., Principles of Virology, 2000. ASM Press
Problem sets: A problem set will be distributed on February 5. This is an open book, take
home exam which is due the following Wednesday. 30% of the final grade.
Final exam: Open book, take home exam. 70% of the final grade.
Final grade: 30% problem set, 70% final exam.