Table 1 Characteristics of included randomized trials on Chinese herbal medicine for recurrent miscarriage
Study
Etiology
ID
Previous
Mean age(range)
Status in
Sample
miscarriages
yrs
recruitm
size(T/C)
(No.)
Intervention（ingredients)
Control
Treatment
Outcomes
duration
ent
(from trial
start to)
He WH
Unexplained
≥3
2011[9]
T: 29.9(19-41);
Try
to
C: 28.5(22-37)
pregnant
75(43/32)
1. Self-made pill before pregnant;
HCG, folic
3-6 months of
2. Sele-made decoction after pregnant (Radix Pseudostellariae,
acid , vitamin E,
gestation
Atractylodes Macrocephala Koidz., Rehmannia Glutinosa (Gaertn.)
progesterone
Live birth rate
Libosch., Colla Corii Asini, Herba Hemiboea, Radix Scutellariae,
Cortex Eucommiae, Herba Taxilli, Dipsacus Asper Wall, Rhizom
Dioscoreae, Fruit of Villous Amomum, Semen Cuscutae Chinensis).
3. Control interventions
Li
Q
Unexplained
≥2
2011[10]
T: 21-35;
Already
C: 22-37
pregnant
60(30/30)
Self-made decoction (Herba Taxilli, Dipsacus Asper Wall, Semen
Progesterone,
34 weeks of
Live birth rate
Cuscutae Chinensis, Colla Corii Asini, Radix Astragali, Radix
vitamin E
gestation
1.Self-made decoction (Semen Cuscutae Chinensis, Herba Taxilli,
Active
T:14-16
Live birth rate,
Dipsacus Asper Wall, Colla Corii Asini, Radix Astragali, Boehmeria
immunotherapy.
weeks of
passive
Nirea (L.) Gaud.)
gestation;
conversion rate
2. Control interventions.
C: 4 times
of blocking
Codonopsis Canescentis, Atractylodes Macrocephala Koidz., Poria,
Radix Angelicae Sinensis, Cortex Eucommiae, Radix Scutellariae,
Glycyrrhiza Uralensis Fisch).
He
GY
Unexplained
≥2
2011[11]
T: 25.62±3.59;
Try
C1:25.25±3.80;
pregnant
to
72(37/35)
C2:25.32±3.89.
antibodies
Huang Y
2010[12]
Unexplained
≥3
T: 28.90±2.54;
C:28.65±2.50
Unclear
64(32/32)
1. Self-made decoction (Radix Codonopsis Canescentis, Radix
Symptomatic
To 80 days of
Astragali, Rehmannia Glutinosa (Gaertn.) Libosch., Atractylodes
treatment before
gestation
Macrocephala Koidz., Herba Hemiboea, Semen Cuscutae Chinensis,
pregnancy;
Dipsacus Asper Wall, Radix Scutellariae, Radix Angelicae Sinensis,
progesterone
Fruit of Villous Amomum).
after pregnancy
Live birth rate
2. Control interventions.
Zhao
R
Unexplained
≥3
22-43
2009[13]
Already
52(27/25)
pregnant
1. Self-made decoction (Glycyrrhiza Uralensis Fisch, Poria, Cortex et
HCG,
3 weeks
Radix Polygalae, Semen Platycladi, Ziziphus jujuba Mill, Fructus
progesterone
exceeding the
Schisandrae, Semen Cuscutae Chinensis, Herba Taxilli, Dipsacus
duration of
Asper Wall, Cortex Eucommiae).
previous
2. HCG.
Ye
LQ
Antiphospholi
2008[14]
pid syndrome
≥2
T: 28.78;
Already
C: 28.82.
pregnant
90 (45/45)
Live birth rate
miscarriage
1. Aspirin.
Aspirin
Till ACA
2. Self-made decoction (Cortex Eucommiae, Semen Cuscutae
changed from
Chinensis, Dipsacus Asper Wall, Herba Taxilli, Atractylodes
positive to
Macrocephala
negative
Koidz.,
Furctus
Lycii
Barbari,
RadixSalviae
Live birth rate
Miltiorrhizae, Radix Angelicae Sinensis, Rhizom Dioscoreae)
Cai XQ
Unclear
≥2
27.5(23-39)
2008[15]
Already
47(25/22)
pregnant
1. Self-made decoction (Semen Cuscutae Chinensis, Dipsacus Asper
Progesterone,
2 weeks
Wall, Herba Taxilli, Furctus Lycii Barbari, Cortex Eucommiae,
HCG,
exceeding the
Atractylodes Macrocephala Koidz., Poria, Radix Astragali, Radix
symptomatic
duration of
Codonopsis Canescentis, Rhizom Dioscoreae, Pedicellus Cucurbitae,
treatment
previous
Boehmeria Nirea (L.) Gaud, Pericarpium Citri Tangerinae, Fruit of
Live birth rate
miscarriage
Villous Amomum).
2. Control interventions
Xie YH
2008[16]
Unclear
≥2
T1:28.5(22-42)
T1:Alrea
T2:28.7(24-46)
C:27.9(25-38).
181(69/65/53)
T1: Before pregnancy: 1. Control interventions. 2.Self-made
Folic acid ,
T1: from
dy
decoction
vitamin E
progestation
pregnant;
Atractylodes Macrocephala Koidz., Radix Angelicae Sinensis,
to 3rd months
T2:Try to
Dipsacus Asper Wall, Rehmannia Glutinosa (Gaertn.) Libosch.,
of gestation;
pregnant;
Semen Cuscutae Chinensis, Fructus Rubi, Furctus Lycii Barbari,
T2 and C:
C: Try to
Fructus Ligustri Lucidi); After pregnancy: 1. vitamin E, folic acid,
from
pregnant.
progesterone, HCG. 2. Self-made decoction (Radix Codonopsis
pregnancy to
Canescentis, Radix Astragali, Dipsacus Asper Wall, Semen Cuscutae
3rd months of
(Radix
Codonopsis
Canescentis,
Radix
Astragali,
Live birth rate
Chinensis, Herba Taxilli, Atractylodes Macrocephala Koidz., Herba
Hemiboea,
Fructus
Psoraleae,
Cortex
Eucommiae,
gestation
Morinda
officinalis How, Poria, Rhizom Dioscoreae, Glycyrrhiza Uralensis
Fisch). T2: the same interventions with T1 after pregnancy
Tian DZ
Hyperprolacti
2006[17]
nemia
≥2
T: 29±3;
Try
C: 28±3.
to
56 (25/31)
1. Self-made decoction (Radix Codonopsis Canescentis, Dipsacus
Bromocriptine,
T: 6 months
Live birth rate,
pregnanc
Asper Wall, Atractylodes Macrocephala Koidz., Semen Cuscutae
folic acid,
of gestation;
endocrine
y
Chinensis, Herba Taxilli, Morinda officinalis How, Polygonum
symptomatic
C: 3 months
indexes
Multiflorum Thunb., Cortex Eucommiae, Fruit of Villous Amomum,
treatment
of gestation
Self-made decoction (Radix Scutellariae, Radix Bupleuri, Rehmannia
Active
T: 6 months
Effective rate,
Rehmannia Glutinosa (Gaertn.) Libosch., Furctus Lycii Barbari);
2. folic acid after pregnancy
Liu
HL
Unexplained
≥3
2005[18]
T: 28.8±3.4;
Try
C:29.2±3.2.
pregnanc
Glutinosa (Gaertn.) Libosch., Rhizom Dioscoreae, Radix Astragali,
immunotherapy:
of gestation;
immune
y
Atractylodes Macrocephala Koidz., Fructus Corni, Dipsacus Asper
intradermal
C: twice
indexes
Wall, Semen Cuscutae Chinensis, Furctus Lycii Barbari)
injection of
Effective rate
to
42 (22/20)
lymphocytes
Zou XD
2005[19]
Unclear
≥3
Unclear
Already
136(68/68)
1.TCM treatment according to syndrome differentiation: decoction
Progesterone,
Longer than
pregnanc
for deficiency of qi and blood: (Radix Codonopsis Canescentis,
vitamin E,
the duration
y
Radix Astragali, Atractylodes Macrocephala Koidz., Dipsacus Asper
Thyroid tablets
of previous
Wall, Radix Angelicae Sinensis, Poria, Herba Hemiboea, Rehmannia
Glutinosa
(Gaertn.)
Libosch.,
Ligusticum
Wallichii
Franch.,
Glycyrrhiza Uralensis Fisch); decoction for kidney deficiency
(Semen Cuscutae Chinensis, Herba Taxilli, Dipsacus Asper Wall,
Colla Corii Asini, Cortex Eucommiae, Rhizoma Cibotii, Folinum
Artemisiae Argyi), decoction for blood heat (Herba Hemiboea,
Atractylodes Macrocephala Koidz., Rhizom Dioscoreae, Dipsacus
Asper Wall, Radix Astragali, Phellodendron Amurense Rupr.,
miscarriage
Glycyrrhiza Uralensis Fisch, Radix Notoginseng), decoction for
bruises (Semen Cuscutae Chinensis, Cortex Eucommiae, Os Sepiae,
Ligusticum Wallichii Franch., Herba Taxilli, Radix Rubiae, Fructus
Psoraleae, Fructus Ligustri Lucidi, Herba Echiptae, Trachycarpus
Wagnerianus Beec.);
2. Control interventions
Zhu HP
Unexplained
≥3
2005[20]
T: 31.2(20-41);
Already
C: 30.6(19-39).
168(88/80)
Self-made decoction (Semen Cuscutae Chinensis, Boehmeria Nirea
Progesterone,
3 months of
pregnanc
(L.) Gaud, Dipsacus Asper Wall, Herba Taxilli, Fructus Corni,
vitamin E, folic
gestation
y
Furctus Lycii Barbari, Atractylodes Macrocephala Koidz., Herba
acid
Live birth rate
Hemiboea, Fruit of Villous Amomum, Radix Scutellariae, Radix
Astragali)
Feng
H
Unclear
≥2
26-36
2005[21]
Already
158 (105/53)
1. Topical creams (Colla Corii Asini, Folinum Artemisiae Argyi,
Progesterone,
T: Unclear;
pregnanc
etc.);
HCG
C: to the
y
2. Shou Tai Wan decoction (Semen Cuscutae Chinensis, Herba
duration of
Taxilli, Dipsacus Asper Wall, Colla Corii Asini)
previous
Live birth rate
miscarriage
Pan
CP
2003[22]
Unclear
≥3
T: 31(22-40;
Already
C: 30.5(22-39).
68(45/23)
1.Shoutaiwan decoction (Radix Codonopsis Canescentis, Radix
Early
More than 12
pregnanc
Astragali, Semen Cuscutae Chinensis, Herba Taxilli, Dipsacus Asper
miscarriage:
weeks of
y
Wall,
vitamin E,
gestation
Atractylodes
Macrocephala
Koidz.,
Herba
Hemiboea,
Glycyrrhiza Uralensis Fisch);
progesterone;
2.Control interventions
Late
miscarriage:
Magnesium
sulfate;
Salbutamol
Live birth rate
Yan KB
Unclear
≥3
27.4(22-36)
2003[23]
T:Try to
185(82/103)
1. Self-made decoction before pregnancy: (Rehmannia Glutinosa
Progesterone,
T: 2 months
Live birth rate
pregnanc
(Gaertn.) Libosch., Fructus Psoraleae, Cortex Eucommiae, Semen
vitamin E,
of gestation;
y;
Cuscutae Chinensis, Radix Pseudostellariae, Radix Astragali,
Sedatives
C: Unclear
C:
Atractylodes Macrocephala Koidz., Herba Taxilli, Furctus Lycii
Already
Barbari, Radix Angelicae Sinensis, Fructus Corni, Fruit of Villous
pregnanc
Amomum, Fructus Jujubae);
y.
2. Self-made decoction after pregnancy: (Radix Pseudostellariae,
1. Antai pill (Herba Taxilli, Dipsacus Asper Wall, Semen Cuscutae
HCG, vitamin
2 months of
Effective rate,
E, progesterone
gestation
negative
Radix Astragali, Cortex Eucommiae, Herba Taxilli, Fructus Corni,
Radix Angelicae Sinensis, Herba Hemiboea, Fruit of Villous
Amomum, Colla Corii Asini, Atractylodes Macrocephala Koidz.,
Semen Cuscutae Chinensis, Radix Scutellariae, Furctus Lycii
Barbari)
Li
WH
Antiphospholi
2003[24]
pid syndrome
≥2
T: 27.6±2.9;
Already
C: 27.3±3.1.
pregnanc
Chinensis,
y
Macrocephala Koidz., Herba Hemiboea, Fructus Ligustri Lucidi,
conversion rate
Polygonum Multiflorum Thunb., Boehmeria Nirea (L.) Gaud,
of ACA
Pericarpium Citri Tangerinae).
antibody
60(30/30)
Radix
Codonopsis
Canescentis,
Atractylodes
2. Control interventions
Shu
J
Antiphospholi
2002[25]
pid syndrome
≥2
T: 28.5±3.1;
Already
C:27.3±2.9.
pregnanc
Astragali, Radix Angelicae Sinensis, Atractylodes Macrocephala
y
Koidz., Phellodendron Amurense Rupr., Plantula Artemisiae
conversion rate
Capillaris, Rhizoma Anemarrhenae, Radix Scutellariae, RadixSalviae
of ACA
Miltiorrhizae, Poria);
antibody
41(23/18)
1. Self-made decoction (Radix Codonopsis Canescentis, Radix
Vitamin
3 months of
Live birth rate,
gestation
negative
2. Control interventions.
Li
P
2000[26]
Unclear
≥3
T: 34(22-45);
Already
C:33(22-40).
90(60/30)
1. Self-made decoction (Radix Codonopsis Canescentis, Atractylodes
Vitamin E,
To the
pregnanc
Macrocephala Koidz., Cortex Eucommiae, Dipsacus Asper Wall,
progesterone.
duration of
y
Rhizoma Cibotii, Colla Corii Asini, Folinum Artemisiae Argyi,
previous
Semen Cuscutae Chinensis, Herba Taxilli, Fructus Alpiniae
miscarriage
Live birth rate
Oxyphyllae, Fructus Psoraleae);
2.Control interventions
Li
XY
1998[27]
Cytomegalovi
≥3
rus infection
T: 27.71±2.39;
Try
C: 26.26±3.79.
pregnanc
to
160(80/80)
Self-made decoction (Radix Astragali, Radix Ginseng, Radix
Vitamin E,
Bupleuri, Isatis Indigotica Fort.)
vitamin C, folic
negative
acid
conversion rate
y
10-90 days
Live birth rate,
of
cytomegalovir
us
Feng CF
Unclear
Unclear
29(23-35)
1998[28]
Already
68(38/30)
pregnanc
Self-made decoction (Colla Corii Asini, Cortex Eucommiae, Semen
Vitamin E,
T: 32 weeks
Cuscutae Chinensis, Dipsacus Asper Wall, Herba Taxilli)
progesterone;
of gestation;
Phenobarbital
C: 2 weeks
y
Live birth rate
exceeding the
duration of
previous
miscarriage
Wang
Unexplained
≥3
YH
T: 29-38.
Already
C: 28-40
pregnanc
Officinalis,
y
Schizonepeta Tenuifolia (Benth.) Briq., Atractylodes Macrocephala
gestation to
Koidz., Fruit of Villous Amomum, Bulbus Fritillariae Cirrhosae,
the last month
Radix Angelicae Sinensis, Ligusticum Wallichii Franch., Rehmannia
before
Glutinosa (Gaertn.) Libosch., Herba Hemiboea)
delivery;
1997[29]
76(38/38)
Self-made decoction (Citrus Aurantium L., Cortex Magnoliae
Semen
Cuscutae
Chinensis,
Colla
Corii
Vitamin E
Asini,
T: from the
Live birth rate
40 days of
C: 4 months
Li
XH
Unexplained
≥3
1995[30]
T: 29.2±5.1;
Already
C: 28.1±4.9.
93(48/45)
1. Shou Tai Wan decoction (Semen Cuscutae Chinensis, Herba
Progesterone,
To the
pregnanc
Taxilli, Dipsacus Asper Wall, Colla Corii Asini);
vitamin E,
duration of
y
2.Control interventions
vitamin C
previous
Live birth rate
miscarriage
Zhang B
Unexplained
≥3
T: 33.7(29-38);
Unclear
31(16/15)
1. Self-made decoction (Unclear ingredients);
Vitamin E,
Unclear
Effective rate
2011[31]
C: 34.2(26-41).
2. Control interventions
symptomatic
treatment
Zhou
Negative
XW
blocking
2011[32]
antibodies
≥3
T: 28.44±5.02;
Try
C: 29.30±3.82.
to
80(40/40)
1. Self-made granules (Semen Cuscutae Chinensis, Herba Taxilli,
Active
T: 3 months;
Effective rate,
pregnanc
Dipsacus
immunotherapy
C: 4 times
positive
y
Macrocephala Koidz., Rehmannia Glutinosa (Gaertn.) Libosch.,
conversion rate
Boehmeria Nirea (L.) Gaud, Herba Echiptae);
of blocking
Asper
Wall,
Radix
Pseudostellariae,
Atractylodes
2. Control interventions
Tian
C
Unexplained
≥2
2011[33]
T: 28.00±5.75
Try
C: 27.06±5.56.
to
64(33/31)
antibodies
Self-made pill (Radix Codonopsis Canescentis, Radix Angelicae
Active
T: 3 months;
Effective rate,
pregnanc
Sinensis, Herba Hemiboea, Atractylodes Macrocephala Koidz.,
immunotherapy
C: 6 times
positive
y
Dipsacus Asper Wall, Cortex Eucommiae, Semen Cuscutae
conversion rate
Chinensis, Radix Scutellariae)
of blocking
antibodies
Fan
LL
Unclear
≥2
Unclear
2010[34]
Already
56(28/28)
1. Modified Shou Tai Wan pill (Semen Cuscutae Chinensis, Herba
Vitamin E,
To 10 weeks
pregnanc
Taxilli, Dipsacus Asper Wall, Colla Corii Asini, Cortex Eucommiae,
symptomatic
of gestation
y
Furctus
treatment
or the
Lycii
Barbari,
Atractylodes
Macrocephala
Koidz.,
Pericarpium Citri Tangerinae);
duration of
2. Control interventions
previous
Effective rate
miscarriage
Yang
S
2010[35]
Luteal phase
defect
≥2
T: 24-35;
Already
55(35/20)
1. Self-made decoction (Radix Ginseng, Radix Astragali, Radix
C: 25-39.
pregnanc
Angelicae Sinensis, Dipsacus Asper Wall, Radix Scutellariae,
y
Ligusticum Wallichii
Franch., Herba
Hemiboea, Rehmannia
Glutinosa (Gaertn.) Libosch., Atractylodes Macrocephala Koidz.,
Fruit of Villous Amomum, Glycyrrhiza Uralensis Fisch, Oryza
Glutinosa, Semen Cuscutae Chinensis, Herba Taxilli, Colla Corii
Asini);
2.Control interventions
Progesterone
Unclear
Effective rate
Wang
Unexplained
≥3
GX
T: 32.5(23-40);
Already
C: 33.1(25-40).
2010[36]
61(31/30)
1. Self-made decoction (Radix Codonopsis Canescentis, Rehmannia
Progesterone,
T: 10 weeks,
Effective rate,
pregnanc
Glutinosa (Gaertn.) Libosch., Rhizom Dioscoreae, Fructus Corni,
HCG
C: 10 days
cytokine
y
Furctus Lycii Barbari, Fructus Ligustri Lucidi, Cortex Eucommiae,
Atractylodes
Macrocephala
Koidz.,
Semen
Lablab
concentrations
Album,
Glycyrrhiza Uralensis Fisch). 2.Control interventions
Hou
X
Unexplained
≥3
28(23-38)
2009[37]
Already
42(30/12)
1. Self-made decoction (Radix Codonopsis Canescentis, Herba
Progesterone,
12 weeks of
pregnanc
Taxilli, Rehmannia Glutinosa (Gaertn.) Libosch., Atractylodes
HCG
gestation or
y
Macrocephala Koidz., Dipsacus Asper Wall, Rhizom Dioscoreae,
longer than
Fructus Corni, Colla Corii Asini, Glycyrrhiza Uralensis Fisch);
the duration
2.Control interventions
of previous
Effective rate
abortion time
Luo DF
Pre-thrombosi
2009[38]
s
≥2
29.4±4.1
Try
to
80(40/40)
Self-made decoction (Ligusticum Wallichii Franch., RadixSalviae
Low molecular
4 months of
Effective rate,
pregnanc
Miltiorrhizae, Radix Angelicae Sinensis, Radix Notoginseng, Pollen
weight heparin,
gestation
endocrine
y
Typhae Angustifoliae, Faeces Trogopterori, Fructus Ligustri Lucidi,
aspirin.
indexes
Herba Echiptae, Rehmannia Glutinosa (Gaertn.) Libosch.)
Li
YH
2009[39]
Unclear
≥3
T: 26(20-40);
Already
120(68/52)
1. TCM treatment based on syndrome differentiation: decoction for
C: 25(20-39).
pregnanc
kidney deficiency and blood heat (Fructus Rubi, Herba Taxilli,
y
Semen Cuscutae Chinensis, Cortex Eucommiae, Dipsacus Asper
Wall, Herba Hemiboea, Radix Scutellariae, Herba Echiptae, Rhizoma
Anemarrhenae, Caulis Bambusae in Taeniam); deficiency of spleen
and kidney (Colla Corii Asini, Radix Codonopsis Canescentis, Radix
Astragali, Atractylodes Macrocephala Koidz., Herba Taxilli,
Rehmannia Glutinosa (Gaertn.) Libosch., Semen Cuscutae Chinensis,
Cortex Eucommiae, Dipsacus Asper Wall, Herba Hemiboea);
2. Control interventions.
Progesterone.
Unclear
Effective rate
Tang YP
Positive
2008[40]
blood
≥2
Unclear
group
antibody
or
Try
to
160(80/80)
Self-made decoction (Radix Angelicae Sinensis, Atractylodes
Aspirin, vitamin
3 months
Effective rate,
pregnanc
Macrocephala Koidz., Herba Hemiboea, Fructus Ligustri Lucidi,
C
before and
endocrine
y
Radix Bupleuri, Cortex Moutan, Radix Scutellariae, Herba Taxilli,
after gestation
indexes
Progesterone
10 days
Effective rate
Self-made decoction (Semen Cuscutae Chinensis, Dipsacus Asper
Progesterone,
3 months
Effective rate
vitamin E
12 weeks of
Effective rate
Antiphospholi
Boehmeria Nirea (L.) Gaud, Glycyrrhiza Uralensis Fisch)
pid syndrome
Wu XY
Unexplained
≥2
28.25±3.70
2008[41]
Already
61(31/30)
Self-made decoction (Semen Cuscutae Chinensis, Herba Taxilli,
pregnanc
Dipsacus Asper Wall, Polygonum Multiflorum Thunb., Radix
y
Codonopsis
Canescentis,
Atractylodes
Macrocephala
Koidz.,
Rehmannia Glutinosa (Gaertn.) Libosch., Radix Astragali, Herba
Hemiboea, Rhizoma Cimicifugae)
Xu
R
Unexplained
≥3
2007[42]
T:29.3±2.8;
Try
C:29.7±3.2.
pregnanc
Wall, Cortex Eucommiae, Herba Taxilli, Radix Codonopsis
y
Canescentis, Radix Astragali, Atractylodes Macrocephala Koidz.,
to
136(86/50)
Fruit of Villous Amomum, Furctus Lycii Barbari, Rehmannia
Glutinosa (Gaertn.) Libosch., Glycyrrhiza Uralensis Fisch)
Ban YH
Unclear
≥3
2003[43]
T:29(23-33);
Already
71(36/35)
Self-made decoction (Dipsacus Asper Wall, Herba Taxilli, Semen
C:29.8(22-29)
pregnanc
Cuscutae Chinensis, Cortex Toonae Sinensis Radicis, Cortex
y
Eucommiae,
RadixSalviae
Miltiorrhizae,
Poria,
Allylestrenol
gestation
Radix
Pseudostellariae, Radix Astragali, Rhizoma Dioscoreae Nipponicae)
Zhao K
Unclear
≥3
2001[44]
T:29.56(26-41)
Already
C:28.54(25-39)
98(58/40)
Self-made decoction (Herba Agrimoniae Pilosae, Semen Cuscutae
Salbutamol,
15 days after
pregnanc
Chinensis, Cortex Eucommiae, Dipsacus Asper Wall, Cortex
progesterone
the duration
y
Moutan, Radix Sangusorbae, Atractylodes Macrocephala Koidz.)
Effective rate
of previous
miscarriage
Yang XS
1998[45]
Unclear
≥3
T: 22-39;
Already
C: 22-37.
56(33/23)
1. Yunkang oral liquid (Radix Codonopsis Canescentis, Radix
Progesterone
pregnanc
Astragali, Rhizom Dioscoreae, Colla Corii Asini, Rhizoma Cibotii,
and placebo of
y
Semen
Yunkang oral
Cuscutae
Chinensis,
Dipsacus
Asper
Wall,
Cortex
Eucommiae, Atractylodes Macrocephala Koidz., Boehmeria Nirea
(L.) Gaud, Folinum Artemisiae Argyi);
liquid
Unclear
Effective rate
2. Placebo of progesterone
Huang
Unclear
≥3
33.89(24-45)
Already
90(30/30/30)
Self-made decoction (Radix Dipsaci, Herba Taxilli, Cortex
C1:Active
T: till birth;
QZ2012
pregnanc
Eucommiae, Colla Corii Asini, Cornu Cervi Degelatinatum, Radix
immunotherapy
C1: 6-12
[46]
y
Codonopsis, Fructus Lycii, Folium Artemisiae Argyi, Radix
C2: Passive
months;
Morindae Officinalis, Fructus Amomi, Radix et Rhizoma Ginseng,
immunotherapy
C2: 20 weeks
1.Modified Shou Tai Wan decoction (Semen Cuscutae, Herba
C1:Dydrogester
Half month
Live birth rate
Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Radix
Rehmanniae Praeparata)
Liu
Luteal phase
BJ2012
defect
≥2
[47]
T:28.2(23-40);C1:
Already
108(36/36/36)
26.9(21-38;C2:27.
pregnanc
Taxilli, Radix Dipsaci, Colla Corii Asini, Radix Astragali, Radix
one;
exceeding the
5(22-40)
y
Codonopsis, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Paeoniae
C2:Progesteron
duration of
Alba, Radix Scutellariae Hypericifoliae, Rhizoma Phragmitis,
e
previous
Rhizoma
Dioscoreae,
Rhizoma
Atractylodis
Macrocephalae,
Effective rate
miscarriage;
Rhizoma Cimicifugae);
increasing
2. dydrogesterone
dosage for
patients with
sign of
miscarriage
for 14 weeks
of gestation
Sun
Y2012
[48]
Unclear
≥2
T:29.1(21-39);
Try
to
160(80/80)
1.Self-made decoction (Semen Cuscutae, Fructus Lycii, Fructus
C:27.8（22-38）
pregnanc
Rubi, Herba Epimedii, Radix Dipsaci, Radix Angelicae Sinensis,
follow-up 9
y
Caulis Spatholobi, Radix et Rhizoma Salviae Miltiorrhizae, Radix
months
Polygoni Multiflori, Fructus Liquidambaris, Rhizoma Cyperi,
Rhizoma Dioscoreae, Herba Taraxaci, Caulis Sargentodoxae, Herba
Patriniae, Fructus Citri Sarcodactylis, Pericarpium Citri Reticulatae,
Folium Mori, Herba Ecliptae, Fructus Ligustri Lucidi, Cortex
Moutan, Folium Eriobotryae);
Vitamine E
3 months，
Live birth rate
2. Control intercentions
Wang
HF2012
[49]
Unclear
≥3
T:25.97±2.35;C:2
Already
6.01±2.34
89(49/40)
1. Le Yun Ning Granule (Radix Dipsaci, Cortex Eucommiae, Fructus
HCG,
4 months of
pregnanc
Psoraleae, Radix Angelicae Sinensis, Radix Astragali, Radix
progesterone
gestation
y
Codonopsis,
Rhizoma
Atractylodis
Macrocephalae,
Dioscoreae, Radix Paeoniae Alba, Fructus Amomi);
2. Control interventions.
Notes: T: treatment group; C: control group; HCG: human chorionic gonadotrophin; ACA: anticardiolipin.
Rhizoma
Effective rate