无损微波热声成像及其应用基础研究（影像学）
项目批准号：30870676
项目负责人：邢达
依托单位： 华南师范大学
本课题组多年来致力于无损快速、高分辨的生物医学成像技术研究，利用快速光声成像在脑
功能检测、肿瘤治疗监控及评价等方面做了一系列开拓性研究。此次拟研究的微波热声成像
是一种原理上与光声成像相似但基于微波激励超声效应反映组织内部微波吸收分布的新兴
医学成像方法。与光声成像相比，热声成像采用检测微波激发超声信号，大大提高成像深度，
更适合于实际应用检测。本课题计划在原有成像技术的基础上，建立一套由微波激发，多元
阵列快速采集及重建的成像系统，并在此系统上开展结合实际应用的基础研究。利用热声成
像反映电磁学参数差异的特性对X光成像无法分辨的低密度异物进行高对比度的成像检测。
并且根据乳腺正常组织和肿瘤之间的高微波吸收差异特性，开展乳腺肿瘤的早期检测，研究
结合微波吸收增强微粒的早期乳腺肿瘤特异性分子成像。最终建成基于微波热声成像的无
损、快速、高分辨高对比度的成像检测方法，为解决目前医学成像盲区提供可靠的新技术。
关 键 词：微波热声成像；无损检测；异物检测；早期乳腺检测
学科代码：H1807
发表论著：（* 通讯作者）
1. Zhao H, Xing D*, Chen Q. New insights of mitochondria reactive oxygen species
generation and cell apoptosis induced by low dose photodynamic therapy. European
Journal of Cancer. 2011, 47(18): 2750-61.(IF=4.944)
2. Zhou F, Wu S, Wu B, Chen W, Xing D*. Mitochondria-Targeting Single-Walled Carbon
Nanotubes for Cancer Photothermal Therapy. Small. 2011, 7(19): 2727-35.(IF=7.333)
3. Huang G, Yang S, Yuan Y, Xing D*. Combining x-ray and photoacoustics for in vivo
tumor imaging with gold nanorods. Applied Physics Letters. 2011, 99(12):
123701.(IF=3.82)
4. Gao G, Yang S, Xing D*. Viscoelasticity imaging of biological tissues with
phase-resolved photoacoustic measurement. Optics Letters. 2011, 36(17):
3341-3.(IF=3.316)
5. Zhang H, Wu S, Xing D*. YAP accelerates A beta(25-35)-induced apoptosis through
upregulation of Bax expression by interaction with p73. Apoptosis. 2011, 16(8):
808-21.(IF=4.397)
6. Liu L, Zhang Z, Xing D*. Cell death via mitochondrial apoptotic pathway due to
activation of Bax by lysosomal photodamage. Free Radical Biology and Medicine. 2011,
51(1): 53-68. (IF=5.707)
7. Zheng X, Xing D*, Zhou F, Wu B, Chen W. Indocyanine Green-Containing Nanostructure
as Near Infrared Dual-Functional Targeting Probes for Optical Imaging and
Photothermal Therapy. Molecular Pharmaceutics. 2011, 8(2): 447-56.(IF=5.4)
8. Wu S, Zhou F, Zhang Z, Xing D*. Mitochondrial oxidative stress causes
mitochondrial fragmentation via differential modulation of mitochondrial
fission-fusion proteins. FEBS Journal. 2011, 278(6): 941-54.(IF=3.129)
9. Zhou Q, Ji X, Xing D*. Full-field 3D photoacoustic imaging based on plane
transducer array and spatial phase-controlled algorithm. Medical Physics. 2011,
38(3): 1561-6.(IF=3.07)
10. Hu J, Yu M, Ye F, Xing D*. In vivo photoacoustic imaging of osteosarcoma in a
rat model. Journal of Biomedical Optics. 2011, 16(2): 020503.(IF=3.188)
11. Zhou F, Yang Y, Xing, D*. Bcl-2 and Bcl-xL play important roles in the crosstalk
between autophagy and apoptosis. FEBS Journal. 2011, 278(3): 403-13.(IF=3.129)
12. Lou C, Xing D*. Temperature monitoring utilising thermoacoustic signals during
pulsed microwave thermotherapy: A feasibility study. International Journal of
Hyperthermia. 2010, 26(4): 338-46. (IF=2.929)
13. Chu J, Wu S, Xing D*. Survivin mediates self-protection through ROS/cdc25c/CDK1
signaling pathway during tumor cell apoptosis induced by high fluence low-power
laser irradiation. Cancer Letters. 2010, 297(2): 207-19.(IF=4.864)
14. Ye F, Yang S, Xing D*. Three-dimensional photoacoustic imaging system in line
confocal mode for breast cancer detection. Applied Physics Letters. 2010, 97(21):
213702.(IF=3.82)
15. Yang L, Wei Y, Xing D*, Chen Q. Increasing the Efficiency of Photodynamic Therapy
by Improved Light Delivery and Oxygen Supply Using an Anticoagulant in a Solid Tumor
Model. Lasers in Surgery and Medicine. 2010, 42(7): 671-9.(IF=3)
16. Cao C*, Nie L, Lou C, Xing D. The feasibility of using microwave-induced
thermoacoustic tomography for detection and evaluation of renal calculi. Physics
in Medicine and Biology. 2010, 55(17): 5203-12.(IF=3.056)
17. Nie L, Ou Z, Yang S, Xing D*. Thermoacoustic molecular tomography with magnetic
nanoparticle contrast agents for targeted tumor detection. Medical Physics. 2010,
37(8): 4193-200. (IF=3.07)
18. Li Y, Xing D*, Chen Q, Chen WR. Enhancement of chemotherapeutic agent-induced
apoptosis by inhibition of NF-kappa B using ursolic acid. International Journal of
Cancer. 2010, 127(2): 462-73.(IF=4.926)
19. Yuan Y, Yang S, Xing D*. Preclinical photoacoustic imaging endoscope based on
acousto-optic coaxial system using ring transducer array. Optics Letters. 2010,
35(13): 2266-8.(IF=3.316)
20. Zhou F, Xing D*, Wu B, Wu S, Ou Z, Chen W. New Insights of Transmembranal Mechanism
and Subcellular Localization of Noncovalently Modified Single-Walled Carbon
Nanotubes. Nano Letters. 2010, 10(5): 1677-81.(IF=12.186)
21. Lou C, Xing D*. Photoacoustic measurement of liquid viscosity. Applied Physics
22. Ma S*, Yang S, Xing D. Photoacoustic imaging velocimetry for flow-field
measurement. Optics Express. 2010, 18(10): 9991-10000.(IF=3.749)
23. Wei Y, Xing D*, Luo S, Yang L, Chen Q. Quantitative measurement of reactive oxygen
species in vivo by utilizing a novel method: chemiluminescence with an internal
fluorescence as reference. Journal of Biomedical Optics. 2010, 15(2): 027006.
(IF=3.188)
24. Yang Y, Xing D*, Zhou F, Chen Q. Mitochondrial autophagy protects against heat
shock-induced apoptosis through reducing cytosolic cytochrome c release and
downstream caspase-3 activation. Biochemical and Biophysical Research
Communications. 2010, 395(2): 190-5. (IF=2.595)
25. Zhou F, Xing D*, Wu S, Chen W. Intravital Imaging of Tumor Apoptosis with FRET
Probes During Tumor Therapy. Molecular Imaging and Biology. 2010, 12(1):
63-70.(IF=3.139)
26. Liu L, Xing D*, Chen W. mu-Calpain regulates caspase-dependent and apoptosis
inducing factor-mediated caspase-independent apoptotic pathways in
cisplatin-induced apoptosis. International Journal of Cancer. 2009, 125(12):
2757-66. (IF=4.926)
27. Nie L*, Xing D, Yang S. In vivo detection and imaging of low-density foreign
body with microwave-induced thermoacoustic tomography. Medical Physics. 2009, 36(8):
3429-37.(IF=3.07)
28. Yin G, Xing D*, Yang Sihua. Dynamic monitoring of blood oxygen saturation in
vivo using double-ring photoacoustic sensor. Journal of Applied Physics. 2009,
106(1): 013109-013109-5.(IF=2.064)
29. Wang X, Xing D*, Liu L, Chen W. BimL directly neutralizes Bcl-xL to promote Bax
activation during UV-induced apoptosis. FEBS Letters. 2009, 583(12): 1873-9.
(IF=3.129)
30. Xiang L, Yuan Y,Xing D*, Ou Z, Yang S, Zhou F. Photoacoustic molecular imaging
with antibody-functionalized single-walled carbon nanotubes for early diagnosis of
tumor. Journal of Biomedical Optics. 2009, 14(2): 021008-021008-7.(IF=3.188)
31. Ou Z, Wu B, Xing D*, Zhou F, Wang H, Tang Y. Functional single-walled carbon
nanotubes based on an integrin alpha(v)beta(3) monoclonal antibody for highly
efficient cancer cell targeting. Nanotechnology. 2009, 20(10): 105102.(IF=3.644)