1
CURRICULUM VITAE
Surname:
MAESTRONI
Forename:
GEORGES JEAN-MARIE
Date of birth:
October 16th, 1947
Birthplace:
Lausanne, Switzerland
Nationality:
Italian
Marital status:
married to Adriana Grandazzi, born1949
2 sons: Diego, born 1974; Tommaso, born 1978.
Present position:
Chief, Center for Experimental Pathology
c/o Istituto Cantonale di Patologia
6604 Locarno, Switzerland.
Academic career:
Ph.D. in Biological Sciences, University of Milano, Italy.
October 1st, 1970 to January 10th, 1973: predoctoral
assistant at the Istituto Italiano di Idrobiologia,
28048 Verbania-Pallanza, Italy.
Visiting Professor, Faculty of Medicine, University of
Siena, Italy, 1992;
Visiting Professor , Faculty of Medicine, University of
Varese, Italy, 1993,1994, 1995, 1996, 1997, 1999,
2000, 2001,2002, 2003
Postdoctoral work:
May 1st, 1973 to August 31st, 1975:
Researcher at the Istituto Italiano di Idrobiologia
of
Verbania-Pallanza, Italy.
Research: Mineralization processes in natural
freshwater ecosystems.
September 1st, 1975 to December 31st, 1976:
Research assistant at the Schweizerisches
Forschungsinstitut, Davos, Switzerland.
Research: neuroendocrine modulation of the
immune response.
January 1st, 1977 to May 31st, 1977:
Training in oncogenesis research at the
Department of Chemical Immunology of the
Weizmann Institute of Science, Rehovot, Israel.
June 1st, 1977 to January 31st, 1981:
Research assistant at the Anatomisches Institut der
Universität, Zürich, Switzerland.
Research: Bone marrow transplantation,
NeuroImmunoModulation.
From February 15th, 1981:
Director of Experimental Pathology at the Istituto Cantonale
di Patologia, Locarno, Switzerland.
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Main research lines: NeuroImmunoModulation:
neural and neuroendocrine control of hematopoiesis and
dendritic cell function, relevance in cancer and immunebased diseases
Other activities
From July 1994 , President of the Consorzio Servizio Idrico
Integrato Alto Lago maggiore
Collaboration with the weekly scientific page of the italian
newspaper “ La Stampa”.
Memberships:
American Association of Immunologists
NY Academy of Science
International Society for Neuroimmunomodulation (Vice-President)
Swiss Society of Pathology
Invited lectures:
University of Mainz, School of Medicine,
Germany, January 1984.
University of Zürich, School of Medicine,
Zürich, Switzerland, June 1987.
University of Genova, School of Medicine,
Genova, Italy, November 1987.
University of Cagliari, School of Medicine,
Cagliari, Italy, February 1988.
University of Milano, School of Medicine,
Milano, Italy, April 1988.
University of California, Los Angeles,
School of Medicine, Los Angeles,
U.S.A., May 1988.
University of München, School of Medicine,
München, Germany, October 1988.
Charles University of Prague, School of
Medicine, Prague, Czechoslovakia,
November 1988.
University of Geneva, School of Medicine,
Geneva, Switzerland, December 1988.
University of Palermo, School of Medicine,
Palermo, Italy, May 1989.
University of Rome, School of Medicine,
Rome, Italy, May 1990.
University of Hannover, School of Medicine,
Hannover, Germany, November 1990.
University of Milan, School of Medicine,
Milan, Italy, October 1993
University of Varese, School of Medicine,
Varese, Italy, 1994-1995-1996
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Triangle Research Center, North Carolina, Laboratory of
Pharmacology & Chemistry, USA,July 11, 1997
University of Granada, Department of Pediatry, School of
Medicine, Spain, April 24, 1998
Charles University, Department of Pharmacology. Prague,
Czech Republic, April 20, 2000
University of Neuchatel, Institute of Zoology,
Neuchatel, Switzerland, April 2002
Referee for:
International Science Foundation
Israel Science Foundation
Italian Research Council
The Wellcome Trust
The Eli and Edythe L. Broad Foundation
Journal of Immunology
Journal of Clinical Investigation
Journal of Neuroimmunology
International Journal of Immunopharmacology
Journal of Pineal Research
Brain, Behavior and Immunity
Trends in Pharmacological Sciences
Life Sciences
Immunopharmacology
NeuroImmunoModulation
Psychoneuroendocrinology
Invited symposia:
International Conference on "Neuromodulation of
Immunity and Hypersensitivity" , Coconut
Grove, Florida, November 12-14, 1984.
Convegno Internazionale, Mente-Corpo-Il Momento unificante. MIlano, Italy,
October 24-26, 1986.
Second
International
Workshop
Neuroimmunomodulation, Dubrovnik,
Jugoslavia, June 1-6, 1986.
European Training Programme in Brain and
Behavior Research. "Stress, Disease and the
Winter School, Zuoz, Switzerland,
January 10-17, 1987
on
Brain".
International Symposium on Immunomodulators:
Biology
and Therapeutic
Applications,Rio
de Janeiro, Brasil, April 26-30, 1987.
First
Stromboli
Conference
on
Aging
Cancer."Neuroimmunomodulation. Interventions
in Aging and Cancer" Stromboli, Italy,
June 7-11, 1987.
and
International Workshop on "The Pineal Gland
and Cancer", Tübingen, Germany, September 6-8,1987.
Simposio Internazionale di medicina Psicosomatica " Lo
shock del futuro",Torino, Italy, March 11-16, 1988.
4
FASEB Summer Conference
"Neuroimmunomodulation" Copper Mountain, Colorado, June 26-July 1,
1988.
X Congresso della Società Italiana di Immunologia e Immunopatologia, Cagliari, Italy,
May 10-12, 1989.
16th
International
Congress
of
Jerusalem, Israel, June 11-16, 1989.
Chemotherapy,
International Congress on Distress,
Neuroimmunomodulation and Ontogeny,
Madonna di Campiglio, Italy, July 26-29,
1989.
International Symposium on "Interactions
between Brain, Nervous system, Behavior and
Immune System", Germany, September 14-16,
1989.
Workshop on Pineal Hormones: Sites of Action
and Physiological Effects, Poznan, Poland,
September 28-30, 1989.
1st
International
Congress
Neuroimmunomodulation (ISNIM), Florence,
Italy, May 23-25, 1990.
for
Nato Advanced Research Workshop
"Role of Melatonin and Pineal Peptides in
Neuroimmunomodulation", Erice, Italy,
June 3-9, 1990.
2nd Geneva Symposium on Psychoimmunology
Geneva, Switzerland, June 26-27, 1990.
Scuola Superiore di Oncologia e Scienze
Biomediche. " Sistema Nervoso Centrale e
Immunità", S. Margherita Ligure, Italy,
September 20-22,1990.
XI Congresso della Società Italiana di Immunologia e Immunopatologia, Verona, Italy,
September 19-22, 1990.
ALPS-ADRIA Immunology and Allergology
Meeting 1990, Rijeka, Jugoslavia,
October 14-17,1990.
VI Congresso Nazionale di Immunofarmacologia, Firenze, Italy, 13-16 December, 1990.
IV Congresso Società Italiana
Palermo, Italy, 4-7 December, 1990.
di
Neuroscienze,
International Conference on Brain and Immunity
Naples, 25-27, March, 1991
International Symposium on Man and His Environment in
Health and Disease, February
27- March 1, 1992, Dallas, Texas, U.S.A.
5
8th Symposium Molecular Biology
Basel, Switzerland, July 9-13, 1993.
of Hematopoiesis,
IX Congresso Nazionale di Immunofarmacologia, Varese,
Italy, 25-28 October, 1993
Neuroimmunomodulation meeting, Annecy, France, May
27-28, 1994.
2nd Alps-Adria Immunology and Allergology Meeting
Opatija, Croatia, September 26-28, 1994
International Course " Melatonin: Mechanisms of Action
and
Therapeutic Implications", Oviedo, Spain,
December15-16 , 1994.
9th Symposium Molecular Biology
Genoa, Italy, June 23-27, 1995.
of
Hematopoiesis,
40th OHOLO Conference: New
Frontiers in Stress
Research: Modulation of Brain Function, Zichron Ya'acov, I
srael, March 24-28, 1996
Workshop: " Mealtonin Recceptors: New Targets for Novel
Therapeutic Agents?", Barcelona, Spain, April 1-2, 1996.
The 25th Annual Meeting of the International Society for
Experimental Hematology, New York, U.S.A.,
August 23-27, 1996.
The 8th NAITO Conference on Neuro-Immuno-Endocrine
Networks (III), Naito Memorial Hall, Gifu, Japan,
October 16-19, 1996.
The Third International Congress International Society for
Neuro-Immuno-Modulation, National Institute of Health,
Bethesda, Maryland, USA, November 13-15, 1996.
Curso Internacional en el conocimiento de las funciones
pineales, Salamanca, Spain, November 28-29, 1996.
SEB Annual Meeting. University of Kent at Kanterbury, UK
7-11 April, 1997.
10th Symposium Molecular Biology of Hematopoiesis.
Hamburg, Germany, July 2-5, 1997.
25th Annual Meeting American Society of Photobiology,
St Louis, Missouri, July 5-10, 1997.
5th Canadian Pineal/Melatonin Symposium,
Ontario, Canada, July 13-15, 1997.
Guelph,
12th IFC European Congress of Clinical Chemistry,
Basel, Switzerland, August 17-22, 1997.
7th Congress of the European Sociaty for Photobiology,
Stresa, Italy, September 8-13, 1997.
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10-
ISTRY meeting, Hamburg, Hamburg, Germany, October
14, 1998.
Thymus and Pineal Gland in Neuroendocrinoimmunology,
Swieradow Zdroj, Poland, October 22-24, 1998.
13th Symposium on Molecular Biology of Hematopoiesis
and treatment of Leukemia and Cancer, New Yor, July 1418, 2000.
The 2nd International conference on the Neuroendocrine
Immune Basis of the Rheumatic Diseases, Genoa, Italy,
September 21-23, 2001
Editor of:
Advances in Pineal Research, Vol. 7, 1994
Journal of Pineal Research
Neuroendocrinology Letters
Ass. Ed. Proceedings 9th Symposium Molecular Biology
of Hematopoiesis, Genoa, Italy, June 23-27, 1995.
Proceedings
2nd
Locarno
Meeting
on
Neuroendocrinoimmunology. Therapeutic Potential of the
Pineal
Hormone Melatonin,
Frontiers in Hormone
Research Vol. 23, Karger, Basel, 1997.
Proceedings, 4th International Congress of the
International Society for Neuroimmunomodulation,
Lugano, Switzerland, Sept 29 - October 2, 1999 , NYAS,
New York
Organizer and chairman of:
1st Locarno Meeting on Neuroendocrinoimmunology,
Locarno, Switzerland, May 25, 1993;
1st
International
Congress
of
Clinical
Neuroimmunomodulation, Monza, Italy, June 10-11, 1995
Session on" Neuroendocrine cytokines in hematopoiesis"
9th Symposium Molecular Biology of Hematopoiesis,
Genoa, Italy, June 23-27, 1995.
2nd Locarno Meeting on Neuroendocrinoimmunology.
Therapeutic Potential of the Pineal Hormone
Melatonin, Locarno, Switzerland, May 5-8, 1996.
Workshop " Neuroendocrine Cytokines" in International
Society for Experimental Hematology., Meeting 96,
New York, USA; August 23-27, 1996.
Workshop Immune-Neuroendocrine Connection in the
12th IFCC European Congress of Clinical
Chemistry,Basel, Switzerland; August 18-22,
1997.
4th International Congress of the International Society
for Neuroimmunomodulation. Sept. 29 - Oct. 2, 1999,
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Lugano, Switzerland.
List of publications of Georges JM Maestroni
Peer reviewed journals
1. Pierpaoli W, Maestroni GJM. 1977. Pharmacological control of the immune response
by blockade of the early hormonal changes following antigen injection. Cell. Immunol. 31, 355363.
2. Pierpaoli W, Maestroni GJM. 1978. Pharmacological control of the hormonally
modulated immune response II.Blockade of antibody production by a combination of drugs
acting on neuroendocrine functions. Immunology, 34, 419-429.
3. Pierpaoli W, Maestroni GJM. 1978. Pharmacological control of the hormonally
modulated immune response III. Prolongation of allogeneic skin graft rejection and prevention of
runt disease by a combination of drugs acting on neuroendocrine functions. J. Immunol. 120,
1600-1603.
4. Pierpaoli W, Maestroni GJM. 1978. Drug induced chimerism and prevention of graftversus-host disease in lethally irradiated mice transplanted with rat bone marrow.
Transplantation, 26, 455-458.
5. Pierpaoli W, Maestroni GJM. 1979. A new preirradiation conditioning regimen which
protect against radiation injury and facilitates engraftment of xenogeneic bone marrow. Scand.
J. Haematol. 22, 165-172.
6. Pierpaoli W, Maestroni GJM. 1979. Prevention of graft versus host disease and
induction of chimerism in lethally irradiated mice reconstituted with rat bone marrow. J. Clin. Lab
Immunol. 2, 125-132.
7. Maestroni GJM, Pierpaoli W. 1979. Pineal function and bone marrow transplantation:
two examples of immune endocrine network. Immunobiology 156, 179-180.
8. Pierpaoli W, Maestroni GJM . 1980. Induction of enduring allogenic bone marrow
chimerism in rabbits via soluble marrow-derived components. Immunology Letters, 1, 255-258.
9. Pierpaoli W, Maestroni GJM. 1980. The facilitation of enduring engraftment of
allogeneic bone marrow and avoidance of secondary disease in mice. Cell. Immunol. 52, 62-72.
10. Maestroni GJM, Pierpaoli W. 1980. Factor(s) elaborated by bone marrow that
promote persistent engraftment of xenogeneic and semiallogeneic marrow. J. Clin. Lab.
Immunol. 4, 189-193.
11. Pierpaoli W, Maestroni GJM, Sache E. 1981. Enduring allogeneic marrow
engraftment via non-specific bone marrow-derived regulating factor(s) (MRF). Cell. Immunol.
57, 219-228.
12. Maestroni GJM, Pierpaoli W, Zinkernagel RM. 1982. Immune-reactivity of long-lived
H-2 incompatible irradiation chimeras (H-2d--H-2b). Immunology, 46, 253-260.
13. Maestroni GJM, Pierpaoli W, Zinkernagel RM. 1983. Allogeneic H-2d--H-2b
irradiation bone marrow chimeras: a) Failure to transfer chimerism adoptively and b) Immune
reactivity of immunocompetent lymphocytes adoptively transferred to chimeras. Immunobiology
164, 417-429.
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14. Maestroni GJM, Pierpaoli W. 1983. Rejection of P2 skin graft by long-lived H-2
incompatible GVHD-free bone marrow chimeras (P1--P2). Transplantation, 36, 461-462.
15. Maestroni GJM, Losa G. 1984. Clinical and immunobiological effects of an orally
administered bacterial extract. Int. J. Immunopharmacol. 6, 111-117.
16. Maestroni GJM. Losa G. 1984. Effect of autologous serum and steroid hormone
rceptors on direct cloning of human breast cancer. Arch. Path. Lab. Med. 108, 283-287.
17. Maestroni GJM. 1984. Anti-HLA-DR autoantibodies in AIDS? Immunology Today, 5,
310-311.
18. Maestroni GJM, Conti A, Pierpaoli W. 1986. Role of the pineal gland in immunity.
Circadian synthesis and release of melatonin modulates the antibody response and antagonizes
the immunosuppressive effect of corticosterone. J. Neuroimmunol. 13, 19-30.
19. Maestroni GJM, Conti A. 1986. Melatonin regulates immunity via an opiatergic
mechanism. Clin. Neuropharmacol. 9, Suppl. 4, 479-481.
20. Maestroni GJM, Conti A, Pierpaoli W. 1987. Role of the pineal gland in immunity. II.
Melatonin enhances the antibody response via an opiatergic mechanism. Clin. Exp. Immunol.
68, 384-391.
21. Maestroni GJM, Conti A. 1988. Role of the pineal gland in immunity. III. Melatonin
antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism.
Immunology 63, 465-469.
22. Maestroni GJM, Conti A. 1989. Beta-endorphin and dynorphin mimic the circadian
immunoenhancing and anti-stress effect of melatonin. Int. J. Immunopharmacol. 11, 333-340.
23. Maestroni GJM, Conti A. 1989. Has the immunoneuroendocrine network any
physiological relevance ? Evidence for a mechanism involving the pineal indole melatonin and
immunoderived opioid agonists (Editorial). J. Intern. Immunology, 1, 151-153.
24. Maestroni GJM, Conti A. 1990. The pineal neurohormone melatonin stimulates
activated CD4+, Thy1+ cells to release opioid agonist(s) with immunoenhancing and anti-stress
properties. J. Neuroimmunol. 28, 167-176.
25. Lissoni P, Barni S, Rovelli F, Viviani S, Maestroni GJM, Conti A, Tancini G. 1990.
The biological significance of soluble interleukin-2 receptors in solid tumors. Eur. J. Cancer 26,
33-36.
26. Lissoni P, Barni S, Archili C, Cattaneo, Rovelli F, Conti A, Maestroni GJM. 1990.
Endocrine effects of a 24-hour intravenous infusion of interleukin-2 in the immunotherapy of
cancer. Anticancer Res. 10, 753-758.
27. Lissoni P, Barni S, DeToma D, Palazzi M, Pipino G, Maestroni GJM, Conti A,
Tancini G. 1990. The pineal hormone melatonin as a second line therapy in metastatic nonsmall cell lung cancer resistant to chemotherapy. Acta Oncologica 11, 41-44.
28. Lissoni P, Brivio F, Barni S, Tancini G, Cattaneo G, Archili C, Conti A and GJM
Maestroni. 1990. Neuroimmunotherapy of human cancer with interleukin-2 and the
neurohormone melatonin : Its efficacy in preventing hypotension. Anticancer Res. 10: 17591762.
29. Giacovazzo M, Conti A, Maestroni GJM, Martelletti P.1991. Stimulation of
lymphocyte natural cytotoxicity in cluster headache patients by melatonin treatment. Cephalalgia
11, 248-249.
30. Maestroni GJM, Conti A. 1991. Anti-stress role of the melatonin-immuno-opioid
network. Evidence for a physiological mechanism involving T cell-derived, immunoreactive b-
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endorphin and met-enkephalin binding to thymic opioid receptors. Int. J. Neurosci. , 61, 289298.
31. Lissoni P, Tisis E, Brivio F, Ardizzoia A, Barni S, Tancini G, Conti A, Maestr0ni GJM.
1991. Modulation of interleukin-2-induced macrophage activation in cancer patients by the
pineal hormone melatonin. J Biol. Reg. Homeost. Agents 5, 154-156.
32.Lissoni P. Barni S, Ardizzoia A, Paolorossi F, Crispino S, Tancini G, Tisi E, Conti A,
Maestroni GJM. 1992. A randomized study with the pineal hormone melatonin versus supportive
care alone in advanced non-small cell lung cancer resistant to a first line chemotherapy containg
cisplatin, Oncology 49, 336-339.
33. Conti A., Haran-Ghera N, Maestroni, GJM. 1992. Role of pineal melatonin and
melatonin-immuno-induced-opioids in murine leukemogenesis. Medical Oncology and Tumor
Pharmacotherapy, 9, 87-92.
34. Lissoni , P., Tisi , E., Brivio, F., Ardizzoia, A., Crispini, S., Barni, S., Tancini, G.,
Conti, A. and G.J.M. Maestroni 1992.. Modulation of Interleukin-2-induced macrophage
activation in cancer patients by the pineal hormone melatonin. J. Biological Regulators and
Homeostatic Agents, 5, 124-156.
35. Lissoni P., Tisi, E., Barni,S., Ardizzoia, A., Rovelli, F., Rescaldani, R., Ballabio, D.,
Benenti, C., Angeli, M., Tancini, G., Conti, A. and G..J.M. Maestroni. 1992. Biological and
clinical results of a neuroimmunotherapy with interleukin-2 and the pineal hormone melatonin as
a first line treatment in advanced non-small cell lung cancer. Br. J. Cancer, 66, 155-158.
36. Lissoni P., Barni , S., Rovelli, F., Brivio, A., Ardizzoia , A., Tancini,G., Conti A.and
G.J.M., Maestroni. 1993. Neuroimmunotherapy of Advanced Solid Neoplasms with Single
Evening Subcutaneous Injection of Low-dose Interleukin-2 and Melatonin: Preliminary Results.
Eur. J. Cancer, 29A, 185-189.
37. Maestroni GJM, Conti A, Pedrinis E. 1992 Effect of adrenergic agents on
hemopoiesis after syngeneic bone marrow transplantation in mice. Blood, 80, 1178-1182.
38. Maestroni GJM. 1993. The immunoneuroendocrine role of melatonin. J. Pineal Res.
14, 1-10.
39. Lissoni P. Pittalis S, Brivio F, Tisi E, Rovelli A, Ardizzoia s, Barni S, Conti A and
GJM Maestroni. 1993. In vitro modulatory effects of interleukin-3 on macrophage activation
induced by interleukin-2 . Cancer 71, 2076-2081.
40. Valcavi R, Zini M, GJM Maestroni, Conti A and I Portioli. 1993. Melatonin stimulates
growth hormone secretion through pathways other than the growth hormone-releasing hormone.
Clin Endocrinol. 39, 193-199.
41. Lissoni P, Barni S, Tancini G, Rovelli F, Ardizzoia A, Conti A and GJM Maestroni.
1993. A study of the mechanisms involved in the immunostimulatory action of the pineal
hormone in cancer patients. Oncology, 50: 399-402.
42. Lissoni P, Ardizzoia A, Tisi S, Rossini E, Barni S, Tancini G, Conti A and GJM
Maestroni. 1993. Amplification of eosinophilia by melatonin during the immunotherapy of cancer
with interleukin-2. J. Biol. Reg. Homeos. Agents, 7 : 34-36.
43. Maestroni GJM and A. Conti. 1994. Noradrenergic
lymphohematopoiesis. Int. J. Immunopharmacol., 16: 117-122.
modulation
of
44. Maestroni GJM and A Conti. 1994. Modulation of hematopoiesis via alpha-1
adrenergic receptors on bone marrow cells. Exp. Hematol., 22: 313-320.
45. Maestroni GJM, Covacci V and A Conti. 1994. Hematopoietic rescue via T-celldependent , endogenous granulocyte-macrophage colony stimulating factor induced by the
pineal neurohormone melatonin in tumor bearing mice. Cancer Res., 54, 2429-2432.
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46. Aldeghi R, Lissoni P, Barni S, Ardizzoia A, Tancini G, Piperno A, Pozzi M, Ricci G,
Conti A and GJM Maestroni. 1994. Low dose interleukin-2 subcutaneous immunotherapy in
association with the pineal hormone melatonin as a first-line therapy in locally advanced or
metasstatic hepatocellular carcinoma. Eur. J. Cancer 30A, 167-170.
47. Maestroni GJM, Conti A, Lissoni P. 1994. Colony stimulating activity and
hematopoietic rescue from cancer chemotherapy compounds is induced by melatonin via
endogenous interleukin 4. Cancer Res., 54, 4740-4743.
48. Grugni G, Carani C, Maestroni GJM, et al. 1994. Melatonin levels in psychogenic
impotence. Horm. metab. Res. 26, 440-441.
49. Maestroni GJM. 1995. T-helper-2 lymphocytes as a peripheral target of melatonin.J.
Pineal Res. 18, 84-90.
50. Maestroni GJM, Flamigni L, Hertens E, Conti A. 1995. Biochemical and functional
characterization of melatonin-Induced opioids in spleen and bone marrow T-helper cells.
Neuroendocrinol. Lett. 17, 145-153.
51. Lissoni P, Barni S,Tancini G, Mainini E, Piglia F, Maestroni GJM. 1995.
Immunoendocrine therapy with low-dose subcutaneous interleukin-2 plus melatonin in locally
advanced or metastatic endocrine tumors. Oncology, 52, 163-166.
52. Brivio F, Lissoni P, Fumagalli L, Brivio O, Lavorato F, Rescaldani R, Conti A, Roselli
MG, Maestroni GJM. 1995. Preoperative neuroimmunotherapy with subcutaneous low-dose
interleukin-2 and melatonin in patients with gastrointestinal tumors: its efficacy in preventing
surgery-induced lymphocytopenia. Oncology Reports, 2, 597-599.
53. Lissoni P, Barni S, Brivio F, Tisi E, Rovelli F, Tancini G, Maestroni GJM. 1995.
Efficacy and tolerability of cancer neuroimmunotrherapy with subcutaneous low-dose
interleukin-2 and the pineal hormone melatonin: A progres report of 200 patients with advanced
solid neoplasms. Oncology Reports 2, 1063-1068.
54. Brackwski R, Zunelewicz B, Romanowski W, Lissoni P, Barni S, Tancini G,
Maestroni GJM. 1995. Preliminary study on modulation of the biological effects of tumor
necrosis factor-alpha in advanced cancer patientsby the pineal hormone melatonin. J. Biol. Reg.
Homeost. Agents 8, 77-80.
55. Maestroni GJM, Conti A, Lissoni P. 1995.Type 2 Th cells as target of the circadian
melatonin signal: Relevance in local immunity. Rnl. Immunol. 6, 350-354.
56. Conti A, Maestroni GJM. 1995. The clinical neuroimmunotherapeutic role of
melatonin in oncology. J. Pineal Res. 19, 103-110.
57. Maestroni GJM. 1996. Melatonin as a therapeutic agent in experimental endotoxic
shock. J. Pineal Res. 20: 84-89.
58. Maestroni GJM. 1996. Adrenergic regulation of hematopoiesis.Pharmacological
Res. 32 : 249-253.
59. Togni M, Maestroni GJM. 1996.
Hematopoietic rescue in mice via 1adrenoceptors on bone marrow B cell precursors. Int. J. Oncology, 9: 313-318.
60. Maestroni GJM, Conti A. 1996. Melatonin in Human Breast Cancer Tissue:
Association with Nuclear grade and Estrogen Recceptor Status. Laboratory Invest. 75: 1-5.
61. Lissoni P, Pittalis S, Ardizzoia A, Brivio F, Barni S, Tancini G, Pelizzoni F,
Maestroni GJM. 1996. Prevention of cytokine-induced hypotension in cancer patients by the
pineal hormone melatonin. Support .Care Cancer 4: 313-316.
62.Conti A, Maestroni GJM. 1996. Role of the pineal gland and melatonin in the
development of autoimmune diabetes in non-obese diabetic mice. J. Pineal Res. 20: 164-172.
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63. Conti A, Maestroni GJM. 1996. HPLC validation of a circadian melatonin rhythm in
the pineal gland of inbred mice. J. Pineal Res. 20: 138-144.
64. Lissoni P, Barni S, Ardizzoia A, Tancini G, Brivio F, Chatikhine V, Maestroni G.
1996. Physiopathology and therapeutic role of the epiphysis in human neoplasms.
Med.Biol.Environ. 24: 19-23.
65. Lissoni P, Paolorossi F. Tancini G, Ardizzoia A, Brivio F, Maestroni GJM. 1996. A
phase II study of tamoxifen plus melatonin in metastatic solid tumor patients. Brit. J. Cancer 74:
1466-1468.
66. Maestroni GJM, Conti A. 1996.
Melatonin and the immune-hematopoietic
system.Therapeutic and adverse pharmacological correlates. NeuroImmunomodulation, 3: 325332.
67. Maestroni GJM, Eisabeth Hertens, Paola Galli, Ario Conti, Ennio Pedrinis. 1996.
Melatonin-induced T-helper cell hematopoietic cytokines resembling both interleukin-4 and
dynorphin. J. Pineal Res., 21: 131-139.
68. Maestroni GJM, Togni M, Covacci V. 1997. Norepinephrine protects mice from
acute lethal doses of carboplatin. Exp. Hematol., 25: 491-494
69. Lissoni P, Tancini G, Barni S, Paolorossi F, Ardizzoia A, Conti A, Maestroni GJM.
1997. Treatment of cancer chemotherapy-induced toxicity with thepineal hormone melatonin.
Support Care Cancer, 5: 126-129.
70. Lissoni P, Cazzaniga M, Tancini G, Scardino E, Musci R, Barni S, Maffezzini M,
Meroni T, Conti A, Maestroni GJM. 1997. Reversal of clinical resistance to LHRH analogue in
metastatic prostate cancer by the pineal hormone melatonin: Efficacy of lHRH analogue plus
melatonin in patients progressing on LHRH analogue alone. Eur. Urol. 31, 178-181.
71.Lissoni P, Paolorossi F , Barni S, Mancuso M, Tancini G, Conti A, Maestroni GJM.
1997. A randomized study of chemotherapy with cisplatin plus etoposide versus
chemoendocrine therapy with cisplatin, etoposide and the pineal hormone melatonin as a firstline treatment of advanced non-small cell lung cancer patients in a poor clinical state. J. Pineal
Res. 23:15-19.
72. Maestroni GJM. 1998. Is hematopoiesis under the influence of neural and
neuroendocrine mechanisms? Histol. Histopathol., 13, 271-274.
73. Maestroni, GJM, Cosentino M, Marino F, Togni M, Conti A, Frigo G. 1998 Neural
and endogenous cathecolamines in the bone marrow. Circadian association of norepinephrine
with hematopoiesis? Exp. Hematol., 26: 1172-1177.
74. Maestroni GJM. 1998. The photoperiod transducer melatonin and the immunehematopoietic system. J. Photochem. Photobiol. : Biol. 43: 186-192.
75. Maestroni GJM. Catecholaminergic
Blood, 92: 2971-2972.
regulation of hematopoiesis in mice.1998.
76. Ghielmini M, Pagani O, Dejong J, Pampallona S, Conti A, Maestroni GJM.1999.
Double-blind randomized study on the myeloprotective effect of melatonin in combination with
carboplatin and etoposide in advanced lung cancer. Brit. J. Cancer , 80: 1058-1061.
77. Maestroni GJM, Hertens E, Galli P. 1999. Factor(s) from nonmacrphage bone
marrow sromal cells inhibit Lewsi lung carcinoma and B16 melanoma growth in mice. Cell. Mol.
Life Sci.,55: 663-667.
78. Reiter RJ, Maestroni GJM. 1999. Mela tonin in relation to the antioxidative defense
and immune systems: Possible implications for cell and organ transplantation. J. Mol. Med.,77:
36-39.
12
79. Maestroni GJM, Zammaretti F, Pedrinis E. 1999. Hematopietic effect of melatonin.
Involvement of type 1 k-opioid receptor on bone marrow macrophages and interleukin-1. J.
Pineal Res. 27 : 145-153.
80. Conti A., Conconi S, Hertens E, Skwarlo-Sonta K, Markowska M, Maestroni GJM.
2000. Evidence for melatonin synthesis in mouse and human bone marrow cells. J. Pineal Res.,
28: 1903-202.
81. Maestroni GJM.2000. Dendritic cell migration controlled by 1b-adrenergic
receptors. J. Immunol. 165: 6743-6747.
82. Cosentino, M., R. Bombelli, M. Ferrari, F. Marino, E. Rasini, G. J. Maestroni, A.
Conti, M. Boveri, S. Lecchini, and G. Frigo. 2000. HPLC-ED measurement of endogenous
catecholamines in human immune cells and hematopoietic cell lines. Life Sci 68:283.
83.
Maestroni, G. J. 2001. Neural regulation of dendritic cell function. Adv Exp Med
Biol 495:111.
84.
Vigano, D., P. Lissoni, F. Rovelli, M. G. Roselli, F. Malugani, C. Gavazzeni, A.
Conti, and G. Maestroni. 2001. A study of light/dark rhythm of melatonin in relation to cortisol
and prolactin secretion in schizophrenia. Neuroendocrinol Lett 22:137.
85.
Lissoni, P., F. Rovelli, F. Malugani, R. Bucovec, A. Conti, and G. J. Maestroni.
2001. Anti-angiogenic activity of melatonin in advanced cancer patients. Neuroendocrinol Lett
22:45.
86.
Lissoni, P., M. Vaghi, A. Ardizzoia, E. Fumagalli, G. Tancini, G. Gardani, A.
Conti, and G. J. Maestroni. 2001. Efficacy of monochemotherapy with docetaxel (taxotere) in
relation to prolactin secretion in heavily pretreated metastatic breast cancer. Neuroendocrinol
Lett 22:27.
87. Maestroni GJM. 2001. The immunotherapeutic potential of melatonin. Exp. Opin.
Invest. Drugs, 10: 467-476.
88.
Maestroni, G. J. M. 2002. Short exposure of antigen-stimulated dendritic cells to
norepinephrine: Impact on kinetic of cytokine production and Th polarization. J. Neuroimmunol.
129:106.
89.
Maestroni, G. J., A. Sulli, C. Pizzorni, B. Villaggio, and M. Cutolo. 2002.
Melatonin in rheumatoid arthritis: a disease-promoting and modulating hormone? Clin Exp
Rheumatol 20:872.
90.
Maestroni, G. J. M., and P. Mazzola. 2003. Langerhans cells 2-adrenoceptors:
Role in migration, cytokine production, Th priming and contact hypersensitivity. J.
Neuroimmunol. 144:91.
91.
Maestroni , G. J. M. 2004. Modulation of skin norepinephrine turnover by
allergen sensitization: Impact on contact hypersensitivity and Th priming. J. Invest. Dermatol.
122:119.
92.
Maestroni, G.J.M. 2004. Immunology needs the mind. Nature Immunology,
5(8):763.
93.
Maestroni, G.J.M. 2004. The endogenous cannabinoid 2-arachidonoyl glycerol
as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble protein,
FASEB J., in press
94.
Maestroni G.J.M., Cardinali ,D., Esquifino, A.I., Pandi-Perumal,S.R.2004.
Does melatonin play a disease-promoting role in Rheumatoid Arthritis? J Neuroimmunol., in
press.
95.
Cutolo M, Maestroni GJ, Otsa K, Aakre O, Villaggio B, Capellino S, Montagna P
13
Fazzuoli L, Veldi T, Pets T, Hertens E, Sulli A. 2004. Circadian melatonin and cortisol levels in
rheumatoid arthritis patients in winter time: a north and south Europe comparison. Ann Rheum
Dis , in press.
Chapters and proceedings
1. Melchiorri-Santolini U, Bertoni R, Maestroni GJM, Mariazzi AA. 1975. Distribution of
pelagic bacterial populations and related ecological factors in a deep lake. In: Proc. 1st Symp.
Intern. Congr. IAMS, Hasegawa T, ed., Vol.2, 385-394.
2. Maestroni GJM, Pierpaoli W. 1981. Pharmacological control of the hormonally
modulated immune response. In: "Psychoneuroimmunology", Ader R, ed., pp. 405-427,
Academic Press, New York.
3. Pierpaoli W, Maestroni GJM. 1983.Marrow regulating factors (MRF) and radiation
chimeras: a model for bone marrow-directed immunity. In: "Immunoregulation" Fabris N, Garaci
E, Hadden J, Mitchison NA, eds., pp.133-140.
4. Maestroni GJM. 1986. Hormonal modulation of the human autologous mixed
lymphocyte reaction . In: "Enkephalins and Endorphins: Stress and the Immune System",
Plotnikoff NP et al. eds.,pp. 321-337, Plenum Press, New York.
5. Maestroni GJM. 1986. Hormones and the human autologous mixed lymphocyte
reaction. Proc. 1st Int. Workshop on Neuroimunomodulation, Bethesda, MA, U.S.A., pp. 157166.
6. Pierpaoli W, Balakrishnan J, Sache E, Choay J, Maestroni GJM. 1987.
Neuroendocrine and bone marrow factors for control of marrow transplantation and tissue
regeneration. Annals NY Acad. Sci., 496, 3-27.
7. Maestroni GJM, Conti A, Pierpaoli W. 1987. The pineal gland and the circadian
opiatergic immunoregulatory role of melatonin. Ann. NY Acad. Sci. 496, 67-68.
8. Maestroni GJM, Conti A, Pierpaoli W. 1987. The pineal neurohormone melatonin and
its physiologic opiatergic immunoregulatory role. Mem. Inst. Oswaldo Cruz, 82, Suppl.11, 75-79.
9. Maestroni GJM, Conti A, Pierpaoli W. 1988. Pineal melatonin: Its fundamental
immunoregulatory role in aging and cancer. Ann. NY Acad. Sci. 521, 140-148.
10. Maestroni GJM, Conti A. 1988. Melatonin counteracts the effect of acute stress via
an opiatergic mechanism. In: "Fundamentals and Clinics in Pineal Research" Trentini GP et al.
eds., Serono Symposia Publications, Vol. 44, pp.277-281, Rven Press, New York.
11. Maestroni GJM, Conti A, Pierpaoli W. 1988. The immunoregulatory role of the pineal
gland. In: "The Pineal Gland and Cancer", Gupta D et al. eds., pp.133-145, Müller and Bass,
Tübingen.
12. Maestroni GJM, Conti A. 1989. Melatonin, stress and the immune system. In: "
Pineal Research Reviews, Vol.7, 203-226.
13. Maestroni GJM, Conti A. 1990. The melatonin-immune system-opioid network. In :
Advances in Pineal Research"4, RJ Reiter, A Lukaszyk, eds., John Libbey & Co Ltd, pp. 233241.
14. Maestroni GJM, Conti A. 1991. Role of the pineal neurohormone melatonin in the
psychoneuroendocrine-immune network. In: "Psychoneuroimmunology II", Ader R, Felten DL,
Cohen N, eds., pp. 495-511, Academic Press, New York.
14
15. Maestroni GJM. 1991. Action of melatonin on immune system. In: Role of melatonin
and pineal peptides in neuroimmunomodulation. F. Fraschini, R. Reiter eds., pp. 201-210,
Plenum Press, New York.
16. Maestroni GJM, Conti A. 1991. The pineal-immuno-opioid network. Mechanisms
and significance. Ann . NY Acad. Sci. USA, 650,56-59
17. Maestroni GJM. 1991. Gabaergic modulation of the immune response. J.Chemoth.,
3: 1-2.
18. Maestroni GJM, Conti A. 1991. Immuno-derived opioids as mediators of the
immunoenhancing and anti-stress action of melatonin. Acta Neurologica, 36, 54-59.
19. Conti A., Maestroni GJM. 1992. Melatonin: does it represent a new
immunomodulatory and anti-stress drug ? In: "Neuroimmunomodulation in Pharmacology",
Second Course of the Federation of the European Pharmacological Societies, Ed. Institut
Pasteur, G. Fillion, (1992)
20. Maestroni GJM , Conti A. 1993. Melatonin in relation to the immune system in:
"Melatonin: Biosynthesis, Physiological Effects, and Clinical Applications" , Hing Sing Yu and
Russel Reiter, Eds. CRC Press, Boca Raton, Florida, pp. 289-311.
21. Conti A, Maestroni GJM. 1993. Do the pineal gland and melatonin play a role in
autoimmunity? EOS J . Immunol. Immunopharmacol. XIII: 42-45.
22.Maestroni GJM. 1994. Modulation of hematopoiesis via a1-adrenergic receptors on
bone marrow cells. in Proc. 8th Symposium Molecular Biology
of Hematopoiesis, Basel,
Switzerland, July 9-13, 1993 , Intercept, Andover, pp 735-749.
23. Maestroni G.J.M., Covacci V, Conti A.1994 Melatonin-induced immuno opioids:
fundamentals and clinical perspectives .In: Advances in pineal research, Vol. 7, John Libbey &
Co, G.J.M. Maestroni, A.Conti and R. Reiter,Eds., pp.73-81.
24. Conti A, Maestroni GJM.1994 Melatonin-induced immuno- opioids: role in
lymphoproliferative and autoimmune diseases. In: Advances in pineal research, Vol. 7, John
Libbey & Co, G.J.M. Maestroni, A.Conti and R. Reiter,Eds., pp. 83-100.
25. Maestroni GJM. 1994. Sympathetic regulation of hematopoiesis.
in:
"Pathophysiology of Immune-Neuroendocrine Communication Circuit" Proc. Int. Symp. ImunoNeuroendocrine Communication Network, May 8-9, 1993, Tübingen, Germany, D.Gupta, H A
Wollmann, PG Fedor-Freybergh, eds., Mattes Verlag , Heidelberg, pp.49-59.
26. Maestroni GJM. 1996. Neuroendocrine Regulation of Hematopoiesis. in:"
Psychoneuroimmunology, Stress and Infection", H Friedman, TW Klein, AL Friuedman eds.,
CRC Press, Boca Raton, pp. 11-127.
27. Maestroni GJM. 1996. Circadian Rhythm and Immunity: T-Helper Cells as Targets
of the Circadian Melatonin Signal. In: The Physiology of Immunity, JA Marsh, MD Kendall eds.
CRC Press, Boca Raton, pp 367-377.
28. Togni M, Maestroni GJM. 1996. Hematopoietic rescue via a1-adrenoceptors on
bone marrow B cell precursors and endogenous transforming growth fcator-b, In: Molecular
Biology of Hematopoiesis 5, NG Abraham, S Asano, G Brittingen, Maestroni GJM, Shadduck,
RK, eds. Plenum Press, New York, pp. 609-617.
29. Maestroni GJM. 1996. Melatonin-induced hematopoietic opioid cytokines. Int. J.
Thymology, 1: 1-5.
30. Conti A, Maestroni GJM. 1997 Melatonin rhythm in mice and its role in autoimmune
diseases. In: Therapeutic Potential of Melatonin, Frontiers of Hormone Research, Vol.23,
Maestroni GJM, Conti A, Reiter R. eds., Karger, Basel, pp52-62.
15
31. Maestroni GJM, Hertens E, Galli P. 1997 New Thelper cells opioid cytokines as
mediators of the immunological and hematopoietic action of melatonin. In: Therapeutic Potential
of Melatonin, Frontiers of Hormone Research, Vol.23, Maestroni GJM, Conti A, Reiter R. eds.,
Karger, Basel, pp 62-72.
32. Ben Nathan D, Maestroni GJM, Conti A.1997. The protective effect of melatonin in
viral and bacterial infections. In: Therapeutic Potential of Melatonin, Frontiers of Hormone
Research, Vol.23, Maestroni GJM, Conti A, Reiter R. eds., Karger, Basel, pp 72-81.
33. Maestroni GJM, Conti A. 1997. Association of melatonin with nuclear grade and
estrogen receptor status in human breast cancer. In: Therapeutic Potential of Melatonin,
Frontiers of Hormone Research, Vol.23, Maestroni GJM, Conti A, Reiter R. eds., Karger, Basel,
pp 125-132.
34. Maestroni GJM. 1998. Melatonin-induced-T-helper cell opioid cytokines with antistress and hematopoietic effects. In: New Frontiers in Stress Research, Levy A, Grauer E, BenNatha D, de Kloet ER, eds., Harwood Acd., Amsterdam, pp. 217-225.
35. Maestroni GJM. 1998. k-Opioid receptors in marrow stroma mediate the
hematopoietic effects of melatonin-induced opioid catokines. In: Neuroimmunomodulation:
Molecular aspects, integrative systems, and clinical advances. McCann,s, Lipton JM, Sternberg,
EM, Chrousos GP, Gold, PW, Smith CC, eds. Ann. NY Acad. Sci, New York, pp. 411-420.
36. Conti A, Maestroni GJM. 1998. Melatonin rhythm in mice : Role in autoimmune and
lymphoproliferative diseases. In: Neuroimmunomodulation: Molecular aspects, integrative
systems, and clinical advances. McCann,s, Lipton JM, Sternberg, EM, Chrousos GP, Gold, PW,
Smith CC, eds. Ann. NY Acad. Sci, New York, pp.395-411.
37. Maestroni, G. J., A. Sulli, C. Pizzorni, B. Villaggio, and M. Cutolo. 2002. Melatonin in
rheumatoid arthritis: synovial macrophages show melatonin receptors. Ann N Y Acad Sci
966:271.
38. Maestroni, G.J.M. 2004. The sympathetic nervous system and melatonin connection
in Rheumatoid Arthritis. In: Focus on Arthritis Research, F. Columbus, Ed., Nova Science
Publisher, Inc. , Hauppauge, NY, in press.
Other journals
1. Maestroni GJM, Bertoni R. 1977. Un nuovo strumento per l'analisi del carbonio e
dell'azoto organici nelle acque. Mem. Ist. Ital. Idrobiol. 34, 131-136.
2. Maestroni GJM.1984 Il "sesto senso", ovvero la connessione tra sistema immunitario
e sitema neuroendocrino quale possibile intermediaria della patologia psicosomatica. Trib.
Med. Ticinese, 49, 529-532.
3 . Maestroni GJM, Conti A. 1987. Il ruolo della ghiandola pineale nell'immunità: sue
applicazioni nelle immunodeficienze. Trib. Med. Ticinese 52, 293-294.
4. Maestroni GJM, Conti A, Barni, S, Lissoni P. 1989, . Neuroimmunomodulazione e
cancro: Dati Sperimentali e osservazioni cliniche preliminari. Nuovi Argomenti di Medicina, 5,
393-398.
5 . Maestroni , GJM, Conti A. and E. Pedrinis. 1991. Sympathetic regulation of
hemopoiesis. Direct noradrenergic modulation og myelocyte and lymphocyte progenitor cells in
mouse bone marrow. Acta Medica Romana 29, 295-310.
6. Covacci., Amodeo R., Provenzano, C., Conti , A., and GJM Maestroni.1992.The
oncostatic and immunoregulatory role of melatonin. Acta Medica Romana 30, 56-62.
16
7. Conti A., Maestroni GJM.1991.The immunoregulatory role of the pineal gland,
melatonin and endogenous opioid system. Acta Medica Romana,29, 19-28.
.
8. Conti A., Maestroni GJM, Pedrinis E. Patologia Sperimentale: Attività di ricerca
indispensabile in un istituto di patologia. Trib. Med. Tic. , 56, Novembre,772-777 1991.