curriculum vitae - Radiation and Cellular Oncology
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CURRICULUM VITAE Name: Ralph R. Weichselbaum Business Address: The University of Chicago Medical Center 5758 S. Maryland Avenue, MC-9006 Chicago, IL 60637-1470 Education/Degrees: 1967 B.S. 1971 M.D. University of Wisconsin, Madison, WI University of Illinois, Chicago, IL Postdoctoral Training: Internship and Residencies: 1971-1972 Medical Intern, Highland-Alameda County Hospital, Oakland, CA 1972-1975 Resident in Radiation Therapy, Harvard Medical School, Joint Center for Radiation Therapy, Boston, MA 02115 Research Fellowships: 1970-1971 Research Fellow, Department of Surgical Oncology University of Illinois, Chicago, IL 1973-1975 Research Fellow, Harvard School of Public Health Laboratory of Radiobiology, Boston, MA 02115 Licensure and Board Certification: American Board of Radiology, (Therapeutic Radiology) Massachusetts: 34518; California: G-25314; Illinois: 036-069-955 Academic Appointments: 1975-1976 Instructor in Radiation Therapy Harvard Medical School, Boston, MA 1977-1980 Assistant Professor in Radiation Therapy, Harvard Medical School, Boston, MA 1979-1982 Research Member, Harvard, MIT, Division Health Sciences, Boston, MA 1980-1984 Associate Professor, Department of Radiation Therapy, Joint Center 1 for Radiation Therapy, Harvard Medical School, Boston, MA 1983-1984 Associate Professor, Department of Cancer Biology, Harvard School of Public Health, Boston, MA 1984-present Professor and Chairman, Department of Radiation and Cellular Oncology, University of Chicago, Division of the Biological Sciences and Pritzker School of Medicine, Chicago, IL 60637 Head, Michael Reese/University of Chicago, Center for Radiation Therapy Director, Chicago Tumor Institute 1985-present Senior Biologist, Argonne National Laboratories, Argonne, IL 1990-2000 Harold H. Hines, Jr., Professor and Chairman, University of Chicago 2000-present Director, Center for Molecular Oncology, University of Chicago 2001-present Daniel K. Ludwig Professorship, University of Chicago 2006 – 2011 Professor of Surgery, University of Chicago (Joint Appointment) 2006-present Co-Director, Ludwig Center for Metastasis Research, University of Chicago Hospital Appointments: 1976-1984 Radiotherapist, New England Deaconess Hospital, Boston, MA 1976-1984 Associate Radiotherapist, Children’s Hospital, Medical Center, Boston, MA Boston Hospital for Women, Beth Israel Hospital, Boston MA 1977-1984 Associate Director, Head and Neck Clinic, Dana Farber Cancer Institute, Boston, MA 1977-1984 Head, Radiotherapy Division, Peter Bent Brigham Hospital, Dana Farber Cancer Institute, Boston, MA 1984- Director, Radiation Oncology, University of Chicago Hospitals and Clinics, Chicago, IL 1984- Director, Radiation Oncology, Michael Reese Hospital and Medical Center, Chicago, IL 1987-2009 Director, LaGrange Treatment Pavilion, LaGrange Memorial Hospital, 2 LaGrange, IL 1993- Lecturer and Chief, Radiation Oncology, University of Illinois Hospital, Chicago, IL Awards and Honors: 1975 American Radium Society, Resident Research Award 1987 Lee Lecture, University of Minnesota 1989 Clifford Allen Lecture, University of Oregon 1991 MacLaren Lecture, Hamilton Regional Cancer Centre, Ontario 1994 Evan and Marion Helfaer Lectureship, Medical College of Wisconsin 1995 Roentgen Centennial Lecturer, University of Zurich 1995 Honorary Member, Swiss Society of Radiology 1996 Ruvelson Lecturer, University of Minnesota 1997 Keynote Lecturer, International Conference of Environmental Mutagenesis, Toulouse, France 1997 Member, Institute of Medicine, National Academy of Sciences 1998 Glenn Sheline Lecturer, University of California, San Francisco 1998 Keynote Lecturer Inauguration Ceremony of the Cancer Center Karolinska Institutet and 70th Anniversary of the King Gustaf’s V Jubilee, Stockholm, Sweden 1998 Lecturer, L Academie des Sciences de institut de France, Paris, France 1998 John B. Little Lecture Award, Harvard University 1999 Keynote Lecturer, American Radium Society Annual meeting, Hawaii 2000 Lecturer, Nobel Symposium, Stockholm, Sweden 2001 Keynote Lecturer, Third International Symposium on Anti-Angiogenic Agents, Irving, Texas 2002 Lecturer, Herman D. Suit Science Festivity Days, Boston, MA 3 2004 Copeland Lecturer, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 2004 Simon Kramer Lectureship, Thomas Jefferson University, Philadelphia, PA 2006 Lecturer and Chair, “Radiation Targeted Gene Therapy: Laboratory and Clinical Studies” A Symposium in Honor of Samuel Hellman, M.D., University of Chicago, Oct. 31 2006. 2009 The Highest Cited Radiation Oncologist of the Past Decade. (K. Choi et al, Int. J. Radiation Oncology Biol. Phys. 74:172-178, 2009). 2010 Lecturer, Annual Tolmach Symposium, Washington University, St. Louis, MO. October 2010. 2011 Keynote Speaker, Thermal Society, Portland OR April 2011 Invited Lectures 2001 Lecturer, Gordon Research Conference, Ventura, California 2004 Lecturer, AACR Special Conference in Cancer Research, Radiation Biology and Cancer: From Molecular Response to the Clinic, Dana Point, CA 2006 Invited Speaker, “Genetic Therapy Approaches with Radiation Therapy Inducible Transcription Units”, Sidney Kimmel Cancer Center Conference, San Diego, CA, Feb 27-Mar 1, 2006. 2006 Invited Speaker, “Applications of Viral Gene Therapy in Combination with Radiation Therapy”, 4th International Chicago Symposium on Malignancies of the Chest and Head & Neck, The Sheraton Chicago Hotel, Chicago, IL, Oct 26-28, 2006. 2007 Invited Speaker, “Targeting the Vascular Endothelium with Radio Inducible Gene Therapy”, The Two-Way Bridge Between the Laboratory and the Clinic: A Symposium in Honor of Zvi Fuks, MD, Memorial Sloan-Kettering Cancer Center, New York, NY, May 21, 2007. 2007 Invited Speaker, “Gene Therapy Targeted by Radiotherapy”, Oncology Grand Rounds, Lombardi Comprehensive Cancer Center, Washington, DC, Dec 7, 2007. 2008 Invited Speaker, “Novel Gene Therapy for Pancreatic Cancer”, Innovations in the Multidisciplinary Treatment of Pancreatic Cancer, The University of Chicago Center for GI Oncology, Sept. 19, 2008. 4 2008 Invited Speaker, Chicago Multidisciplinary Symposium in Thoracic Oncology, Chicago, IL, November 13-15, 2008. 2009 Invited Speaker, Meet-the Expert Sessions, “Control of Gene Therapy by Ionizing Radiation: Basic Principles to Clinical Trials”. AACR Annual Meeting, Denver, CO, April 2009. 2009 Invited Speaker, ASTRO’s 51st Annual Meeting, “Oligometastasis in Bone and Soft Tissue: The Biology of Single Fraction Radiation”. ASTRO’s 51st Annual Meeting, Chicago, IL. November 2009. 2011 Invited Speaker, 102nd AACR Annual Meeting, “Systems Biology at the Clinic”, Orlando, FL., April 2-6, 2011. Memberships, Offices and Committee Assignments in Professional Societies: 1972 1973 1976 1977 1978 1979 1981 1982 1983 1983 1983 1983 1983 1984 1984 1985 1985 1985 1985-87 1986-87 1986-88 1987-89 1987 New England Roentgen Ray Society New England Society for Radiation Oncology American Society of Therapeutic Radiology American College of Radiology Radiation Research Society American Society for Clinical Oncology Study Section, American Cancer Society, Boston Committee on Cancer Management, American College of Radiology Study Section, American Cancer Society, New York (National) American Association for Advancement in Science ASTR Committee on Biology and Physics American Association for Cancer Research American Society for Head and Neck Surgery Extramural Advisory Committee, M.D. Anderson Hospital, Houston, TX Society of Academic Radiation Oncology Chairmen ASTRO Committee on Academic Radiation Oncology Executive Committee, University of Chicago Cancer Center Study Section, National Institutes of Health, Experimental Therapeutics "B" Inter Society Council for Radiation Oncology Committee on Radiotherapy Research and Development, American College of Radiology Award Identification Committee, Radiation Research Society Upper Aerodigestive Tract Committee Working Group, National Cancer Institute External Advisory Committee, Department of Radiation 5 1987-88 1988 1988 1988 1989-93 1989 1989 1990 1990 1990 1990 1990 1991 1991 1991 1991 1991 1992 1992 1993 1993 1993 1993 1993 1993 1993 1993-95 1994-95 1994 1994 Oncology, University of Arizona Co-Chairman, Cancer Committee, University of Chicago Chairman, Pathology Review Committee, University of Chicago External Advisory Committee Department of Radiation Therapy, University of Michigan Chairman, Cancer Task Force, Michael Reese Hospital Board of Scientific Counselors, Division of Cancer Treatment, National Cancer Institute Organizing Committee, 15th LH Gray Conference, Canterbury, England American Society of Microbiology External Advisory Committee, Commonwealth of Virginia, Cancer Center Oncology Council of the Medical Staff, Michael Reese Hospital and Medical Center External Advisory Committee, Department of Radiation Therapy, University of Massachusetts Chairman, NCI Workshop on Mechanisms of Radioresistance Organizer, Fannie May Symposium, "The Cell Cycle from Yeast to Beast " University of Chicago Organizing Committee, "Neoplastic Transformation Human Cell Systems in vitro Mechanisms of Carcinogenesis", Georgetown University Consultant, Onco Med Incorporated External Advisory Committee, University of Illinois Chicago General Motors Award Committee, Kettering Prize Co-Course Director, Concomitant Chemoradiotherapy for Solid Tumors, University of Chicago Comprehensive Cancer Center External Scientific Advisory Committee, Duke University The Board of Chancellors, American College of Radiation Oncology Vice-Chairman, Kettering Committee General Motors Award Radiation Research Society - Strategic Planning Committee Committee to Evaluate the Relationship between Argonne National Laboratory and The University of Chicago External Review Committee, University of Arizona Site Selection Committee, Radiation Research Program Committee, Radiation Research Founding Scientist - Gen Vec Board of Directors, American College Radiation Oncology Rosenthal Awards Committee AACR Organizer, University of Chicago Symposium in honor of Samuel Hellman, M.D., The Therapeutic Promise of Molecular Oncology Committee on Cancer Biology, The University of Chicago 6 1995 1995 1995 1995 1995 1995 1995 1995 1996 1996-97 1996 1997 1997 1997 1997 1998 1998 1998 1999 2000 2000 2000 2000 2000 2002-05 2002 2004 2004 2004-5 2004 Co-Chairman, Cancer Advisory Committee - GEN-VEC Onkoservices Scientific Advisory Board Member Organizing Committee, A Workshop on "Neoplastic Transformation in Human Cell Systems in Culture: Mechanisms of Carcinogenesis" The University of Chicago and Georgetown University Symposium Director, "Concomitant Chemoradiotherapy for Solid Tumors", The University of Chicago International Editorial Board, Cancer Gene Therapy External Advisor, Comprehensive Cancer Center, University of Alabama, Birmingham Fourth International Congress on Gene Therapy Committee Prostate Cancer Executive Committee/Steering Committee, The University of Chicago Clinical Cancer Research Committee (AACR) American Radium Society AACR Clowes Memorial Award Committee/American Association for Cancer Research National Advisory Board, Wendy Will Case Cancer Fund, Inc. External Advisor, Gene Therapy Program, M.D. Anderson Hospital, Houston TX NIH Conference on Herpes Vectors for Gene Therapy Founding Scientist ROMCOR & Consulting Scientist NeurVir External Advisory Committee, University of Wisconsin Cancer Center Founding Scientist Convengence Therapeutics (Sold to ILEX) Scientific Advisory Board, NeuroVir, Inc. NIH Conference, AMolecular Biology of Mutational Biomarkers for Human Exposure to Ionizing Radiation, Bethesda, MD Member, Institute of Medicine, National Academy of Sciences ASTRO Cancer and Radiation Biology Committee External Advisory Committee, Columbia University Cancer Center, New York, New York Medical Advisory Board, iMetricus Scientific Advisory Board, PrevOnc Member of Lung Cancer Committee, American College of Surgeons The Committee on Intellectual Properties, University of Chicago American Society of Gene Therapy Committee on Molecular Medicine, University of Chicago External Scientific Advisory Committee, Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, NC Co-Chair, Medical Review Committee, University of Chicago Co-Chair, Department of Medicine Search Committee, University of Chicago Radiation Research Society, Councilor – Medicine 7 2005 2006 2010 2011-2014 Association of American Physicians Co-Director, Ludwig Center for Metastasis Research, University of Chicago Cardiology Review Committee, University of Chicago Member, National Cancer Policy Forum (NCPF), Institute of Medicine (IOM) Editorial Services 1988 Editorial Board, Radiation Research 1988 Editorial Board, International Journal Radiation Oncology, Biology, and Physics 1990-91 Editorial Board, Yearbook of Oncology 1991-94 Editorial Board, Radiotherapy and Oncology, (ESTRO), Journal of the European Society for Therapeutic Radiology and Oncology, The Netherlands 1992 Editorial Board, Cancer Research 1992-93 Advisory Editor, Radiation Oncology Investigations 1993 Editorial Academy - The International Journal of Oncology 1995-98 Editor, International Journal of Radiation Oncology, Biology, Physics 1996-97 Editor, Encyclopedia of Cancer 1997-99 Editorial Board, Cancer Research (AACR) 2001 Editorial Board, Cancer Biology and Therapy 2008 Editorial Board, Journal of Oncology, Hindawi Publishing Corporation 8 PATENTS Disclosure Patent Title Number 328 Control of Gene Expression by Ionizing Radiation 328 Gene Transcription and Ioninzing Radiation Methods and Compositions 328 Control of Gene Expression by Ionizing Radiation 328 Gene Transcription and Ioninzing Radiation Methods and Compositions 328 Control of Gene Expression by Ionizing Radiation 328 Gene Transcription and Ioninzing Radiation Methods and Compositions 328 Control of Gene Expression by Ionizing Radiation 328 Gene Transcription and Ioninzing Radiation Methods and Compositions 328 Control of Gene Expression by Ionizing Radiation 328 Gene Transcription and Ioninzing Radiation Methods and Compositions 328 Control of Gene Expression by Ionizing Radiation 328 Gene Transcription and Ioninzing Radiation Methods and Compositions 328 Control of Gene Expression by Ionizing Radiation 328 Gene Transcription and Ioninzing Radiation Methods and Compositions 328 Gene Transcription and Ioninzing Radiation Methods and Compositions 328 Gene Transcription and Ioninzing Radiation Methods and Compositions 328 Control of Gene Expression by Ionizing Radiation 328 Gene Transcription and Ioninzing Radiation Methods and Compositions 328 Control of Gene Expression by Ionizing Radiation 328 Gene Transcription and Ioninzing Radiation Methods and Compositions 328 Control of Gene Expression by Ionizing Radiation 328 Gene Transcription and Ioninzing Radiation Methods and Compositions Patent Status Lineage Country Issued Issued Nationalized PCT Australia Nationalized PCT Australia Patent App Number 91702/91 48509/93 Filing Date Patent Issue Date Number 12/19/1991 657111 6/20/1995 9/8/1993 686112 5/21/1998 Issued Issued Nationalized EPO Austria Nationalized EPO Austria 92903431.2AT 93921410.2AT 12/19/1991 563278 9/8/1993 E 295 889 3/8/2000 5/18/2005 Issued Issued Nationalized EPO Belgium Nationalized EPO Belgium 92903431.2BE 93921410.2BE 12/19/1991 9/8/1993 563278 662137 3/8/2000 5/18/2005 Allowed Pending Nationalized PCT Canada Nationalized PCT Canada 2,098,849 2,144,406 12/19/1991 9/8/1993 Issued Issued Nationalized EPO Denmark Nationalized EPO Denmark 92903431.2DK 93921410.2DK 12/19/1991 9/8/1993 563278 662137 3/8/2000 5/18/2005 Issued Issued Nationalized EPO France Nationalized EPO France 92903431.2FR 93921410.2FR 12/19/1991 9/8/1993 563278 662137 3/8/2000 5/18/2005 Issued Issued Nationalized EPO Germany Nationalized EPO Germany 92903431.2DE 93921410.2DE 3/8/2000 5/18/2005 Issued Nationalized EPO Greece 3054313 Issued Nationalized EPO Ireland 93921410.2IE 12/19/1991 563278 9/8/1993 69333815 .6 9/8/1993 20050402 281 9/8/1993 662137 Issued Issued Nationalized EPO Italy Nationalized EPO Italy 92903431.2IT 93921410.2IT 12/19/1991 9/8/1993 563278 662137 3/8/2000 5/18/2005 Issued Pending Nationalized PCT Japan Nationalized PCT Japan 503403/92 508137/94 12/19/1991 9/8/1993 3337214 8/9/2002 Issued Issued Nationalized EPO Lichtenstein Nationalized EPO Luxembourg 92903431.2LI 93921410.2LU 12/19/1991 9/8/1993 563278 662137 3/8/2000 5/18/2005 5/18/2005 5/18/2005 9 328 328 328 328 328 328 328 328 328 328 328 328 328 328 328 328 328 328 328 454 488 Gene Transcription and Ioninzing Radiation Methods and Compositions Control of Gene Expression by Ionizing Radiation Gene Transcription and Ioninzing Radiation Methods and Compositions Gene Transcription and Ioninzing Radiation Methods and Compositions Control of Gene Expression by Ionizing Radiation Gene Transcription and Ioninzing Radiation Methods and Compositions Control of Gene Expression by Ionizing Radiation Gene Transcription and Ioninzing Radiation Methods and Compositions Control of Gene Expression by Ionizing Radiation Gene Transcription and Ioninzing Radiation Methods and Compositions Control of Gene Expression by Ionizing Radiation Issued Nationalized EPO Monaco 93921410.2MC 9/8/1993 662137 5/18/2005 Issued Issued Nationalized EPO Netherlands Nationalized EPO Netherlands 92903431.2NL 93921410.2NL 12/19/1991 9/8/1993 563278 662137 3/8/2000 5/18/2005 Issued Nationalized EPO Portugal 93921410.2PO 9/8/1993 662137 5/18/2005 Issued Issued Nationalized EPO Spain Nationalized EPO Spain 92903431.2ES 93921410.2ES 12/19/1991 9/8/1993 563278 662137 3/8/2000 5/18/2005 Issued Issued Nationalized EPO Sweden Nationalized EPO Sweden 92903431.2SE 93921410.2SE 12/19/1991 9/8/1993 563278 662137 3/8/2000 5/18/2005 Issued Issued Nationalized EPO Switzerland Nationalized EPO Switzerland 92903431.2CH 93921410.2CH 12/19/1991 9/8/1993 563278 662137 3/8/2000 5/18/2005 Issued 92903431.2GB 12/19/1991 563278 3/8/2000 Gene Transcription and Ioninzing Radiation Methods and Compositions Gene Transcription and Ionizing Radiation: Methods and Compositions Control of Gene Expression by Ionizing Radiation Gene Transcription and Ionizing Radiation: Methods and Compositions Control of Gene Expression by Ionizing Radiation Gene Transcription and Ionizing Radiation: Methods and Compositions Gene Transcription and Ionizing Radiation:Methods and Compositions Gene Transcription and Ionizing Radiation: Methods and Compositions Constitutive Gene Expression in Conjunction with Ionizing Radiation Phospholipase A2 Inhibitors as Mediators of Gene Expression Issued 93921410.2GB 9/8/1993 662137 5/18/2005 07/943,812 9/11/1992 6,605,712 8/12/2003 Issued Issued Nationalized EPO United Kingdom Nationalized EPO United Kingdom Continuation in United States Part Continuation United States Divisional United States 08/212,308 08/474,445 3/14/1994 5,612,318 6/7/1995 5,770,581 3/18/1997 6/23/1998 Issued Issued Continuation Continuation United States United States 08/486,338 09/102,997 6/7/1995 5,817,636 6/22/1998 6,156,736 10/6/1998 12/5/2000 Issued Continuation United States 09/730,630 12/5/2000 7,041,653 5/9/2006 Pending Divisional United States 11/257,553 10/26/2005 Pending US Utility United States 08/289,290 8/11/1994 Issued Continuation United States 08/248,058 5/24/1994 6,486,170 11/26/2002 Issued 10 488 488 488 490 498 498 498 498 498 498 498 498 498 498 498 498 498 498 498 DNA Damaging Agents in Combination with Tyrosine Kinase Inhibitors DNA Damaging Agents in Combination with Tyrosine Kinase Inhibitors DNA Damaging Agents in Combination with Tyrosine Kinase Inhibitors Regulation of X-Ray Mediated Gene Expression Treatment of Tumor with Genetically Engineered Hepes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Recombinant Herpes Simplex Virus Useful for Treating Neoplastic Disease Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Issued United States 08/309,315 8/19/1994 6,524,832 2/25/2003 Issued Continuation in Part Continuation United States 10/375,684 2/24/2003 7,070,968 7/4/2006 Pending Continuation United States 11/381,311 Issued Issued Divisional United States Nationalized PCT Australia 08/278,452 29800/00 7/20/1994 5,641,755 2/4/2000 772471 Pending Nationalized PCT Australia 2004203458 7/29/2004 Issued Nationalized PCT Austria 09908465.8AT 2/4/2000 1150696 5/10/2006 Issued Nationalized PCT Belgium 09908465.8BE 2/4/2000 1150696 5/10/2006 Pending Nationalized PCT Canada 2,356,937 12/31/1998 Pending Nationalized PCT Canada 2,361,892 2/4/2000 Pending 06009428.1EP O 09908465.8FR 2/4/2000 Issued Nationalized PCT European Patent Office Nationalized EPO France 1150696 5/10/2006 Issued Nationalized EPO Germany 09908465.8DE 2/4/2000 60027870 5/10/2006 Issued Nationalized EPO Ireland 09908465.8IE 2/4/2000 1150696 5/10/2006 Issued Nationalized EPO Italy 09908465.8IT 2/4/2000 1150696 5/10/2006 Pending Nationalized PCT Japan 2000-592428 12/31/1998 Pending Nationalized PCT Japan 2000-596972 2/4/2000 Issued Nationalized EPO Luxembourg 09908465.8LU 2/4/2000 1150696 5/10/2006 Issued Nationalized EPO Monaco 09908465.8MC 2/4/2000 1150696 5/10/2006 5/2/2006 2/4/2000 6/24/1997 9/30/2004 11 498 498 498 498 498 498 499 499 499 512 512 512 512 512 512 512 531 649 649 649 Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Treatment of Tumors with Genetically Engineered Herpes Virus Recombinant Herpes Simplex Virus Useful for Treating Neoplastic Disease Methods and Compositions for Viral Enhancement of Cell Killing Methods and Compositions for Viral Enhancement of Cell Killing Methods and Composition for Viral Cell Killing Method of Inducing Gene Expression by Ionizing Radiation Method of Inducing Gene Expression by Ionizing Radiation Method of Inducing Gene Expression by Ionizing Radiation Method of Inducing Gene Expression by Ionizing Radiation Method of Inducing Gene Expression by Ionizing Radiation Method of Inducing Gene Expression by Ionizing Radiation Method of Inducing Gene Expression by Ionizing Radiation Methods and Compositions for Targeting Selectins Chelerythrine-based therapies for cancer. Chelerythrine-based Therapies for Cancer Issued Nationalized EPO Netherlands 09908465.8NL 2/4/2000 1150696 Issued Nationalized EPO Spain 09908465.8ES 2/4/2000 1150696 5/10/2006 Issued Nationalized EPO Switzerland 09908465.8CH 2/4/2000 1150696 5/10/2006 Issued 09908465.8GB 2/4/2000 1150696 5/10/2006 Pending Nationalied EPO United Kingdom Continuation United States 09/964,042 9/26/2001 Pending Continuation 11/546,233 10/11/2006 Pending Nationalized PCT Canada 2,234,060 10/7/1996 Pending Nationalized PCT Japan 514508/97 10/7/1996 Pending Issued Nationalized PCT United States Nationalized PCT Australia 10/946,365 26891/95 9/21/2004 5/11/1995 Issued Nationalized PCT Canada 2,192,813 5/11/1995 2,192,813 Issued Nationalized EPO France 95922079.9FR 5/11/1995 759083 2/28/2007 Issued Nationalized EPO Germany 95922079.9DE Issued Nationalized EPO Italy 95922079.9IT 5/11/1995 DE69535 407.8-08 5/11/1995 759083 2/28/2007 Issued Nationalized EPO United Kingdom US Utility United States 95922079.9GB 5/11/1995 759083 2/28/2007 08/241,863 5/11/1994 5,571,797 11/5/1996 US Utility United States Nationalized PCT Canada Nationalized PCT European Patent Office Nationalized PCT Japan 08/392,541 2,418,982 01962027.7EP O 10-545947 2/21/1995 5,962,424 8/8/2001 8/8/2001 10/5/1999 Chelerythrine and Radiation Combined Tumor Therapy Pending Issued Issued Pending Pending United States 696,210 12/17/1998 5/1/2007 3/25/1998 12 649 649 692 692 692 692 692 847 847 847 847 856A 856B 876 876 890 890 890 890 890 Chelerythrine and Radiation Combined Tumor Therapy Chelerythrine-Based Therapies for Cancer Combination of Radiotherapy and Anti-Angiogenic Factors Combination of Radiotherapy and Anti-Angiogenic Factors Combination of Radiotherapy and Anti-Angiogenic Factors Combination of Radiotherapy and Anti-Angiogenic Factors Combination of Radiotherapy and Anti-angiogenic Factors Genetically-Engineered Herpes Virus for the Teratment of Cardiovascular Disease Genetically Engineered Herpes Virus for the Treatment of Cardiovascular Disease Genetically Engineered Herpes Virus for the Treatment of Cardiovascular Disease Genetically Engineered Herpes Virus for the Treatment of Cardiovascular Disease Use of Anti-VEGF Antibody to Enhance Radiation in Cancer Therapy Use of DF3/MUC1 Regulated Expression in Gene Therapy Methods and Kits for Use in Selecting Approaches to Treating Cancer Methods and Kits for Use in Selecting Approaches to Treating Cancer Chemotherapeutic Induction of EGR-1 Promoter Activity Chemotherapeutic Induction of EGR-1 Promoter Activity Chemotherapeutic Induction of EGR-1 Promoter Activity Chermotherapeutic Induction of EGR-1 Promoter Activity Combination Therapies for Cancer Issued US Utility United States 08/826,814 Issued Issued US Utility United States Nationalized PCT Australia 09/637,816 45707/99 Pending Nationalized PCT Canada 2,335,038 6/15/1999 Pending 99928705.5EP O 2000-554393 6/15/1999 Pending Nationalized PCT European Patent Office Nationalized PCT Japan Issued US Utility 09/334,084 Pending Nationalized PCT Australia 200217885 11/28/2001 Pending Nationalized PCT Canada 2,430,341 11/28/2001 Pending Nationalized PCT Japan 2002-546435 11/28/2001 Issued US Utility 09/995,475 11/28/2001 6,846,670 Pending Nationalized PCT European Patent Office US Utility United States 00931923.7EP O 10/244,705 Pending Nationalized PCT European Patent Office US Utility United States 02786375.2EP O 10/492,239 Issued Nationalized PCT Australia 2002303247 Pending Nationalized PCT Canada 2,442,971 Pending Pending Nationalized PCT European Patent Office Nationalized PCT Japan 02731264.4EP O 2002-578888 Pending US Utility 11/467,799 Pending Pending United States United States United States 3/25/1997 6,025,365 2/15/2000 8/11/2000 6,426,351 7/30/2002 12/28/2000 762615 10/16/2003 12/15/2000 6/16/1999 6,420,335 7/16/2002 1/25/2005 4/7/2000 9/16/2002 10/9/2002 4/9/2004 4/5/2002 20023032 47 4/5/2002 7/7/2005 4/5/2002 4/5/2002 8/28/2006 13 1037 1037 1197 1197 1250 1250 1250 1262 1290 1324 1362 1374 1504 Induction of Apoptosis by Cellular Stress Induction of Apoptosis by Cellular Stress Combination Therapy of Hedgehog Inhibitors, Radiation and Chemotherapeutic Agents Combination Therapy of Hedgehog Inhibitors, Radiation and Chemotherapeutic Agents Use of the Combination Comprising Temozolomide and TNF-Alpha for Treating Glioblastoma Use of the Combination Comprising Temozolomide and TNF-Alpha for Treating Glioblastoma Use of the Combination Comprising Temozolomide and TNF-Alpha for Treating Glioblastoma Image-Guided Medical Intervention Apparatus and Method Methods and Kits for Monitoring Barrett's Metaplasia Gamma 1 34.5 Deficient HSV and the MAPK Pathway Methods for Altering Expression of Resveratrol Responsive EGR-1 Promoters Prognosis and Therapy Predictive Markers and Methods of Use Combination Therapy for Treating Cancer Issued Pending Pending US Utility United States US Utility United States Nationalized PCT Japan 10/125,003 11/538,186 pnd-922349016JP00 11/576,310 4/18/2002 7,118,862 10/10/2006 10/3/2006 9/30/2005 Pending US Utility Pending Nationalized PCT Canada 2,577,550 8/25/2005 Pending Nationalized PCT European Patent Office 05804363.9EP O 8/25/2005 Pending US Utility United States 11/574,108 3/6/2007 Pending US Utility United States 10/998,509 11/29/2004 Pending Continuation United States 11/367,602 3/2/2006 Pending PCT US Utility PCT/US07/610 02 60/883,933 1/24/2007 Pending United States PCT United States Pending PCT Provisional PCT/US07/607 83 60/888,823 1/19/2007 Pending United States PCT United States United States 9/30/2005 1/8/2007 2/8/2007 14 PUBLICATIONS AND BOOK CHAPTERS 1. Weichselbaum RR, Patel M, and DasGuptaTK: Influence of the Pineal on Wound Healing. Nature 254:349, 1975. 2. Lampidis T, Weichselbaum RR, and Little JB: Gamma-irradiation of Mammalian Beating Heart Cells In Vitro: Effects on Cellular Function. Int. J. Radiat. Biol. Phys. 28:99-102, 1975. 3. Weichselbaum RR, and Hellman S: The Role of Radiation Therapy in Association with Operation in the Management of Breast Cancer. In Controversy in Surgery. Varco RL, and Delaney (eds.), Saunders JP (publs.), Philadelphia, PA, pps.83-90, 1976. 4. Weichselbaum RR, Epstein J, Little JB, and Kornblith PL: In Vitro Cellular Radiosensitivity of Human Malignant Tumors. Europ. J. of Cancer 12:47-51, 1976. 5. Weichselbaum RR, Epstein J, Little JB, and Kornblith PL: Inherent Cellular Radiosensitivity of Human Tumors of Varying Clinical Curability. Am. J. Roentgenol. 127: 1027-1032, 1976. 6. Weichselbaum RR, Marck A, and Hellman S: The Role of Postoperative Irradiation in Carcinoma of the Breast. Cancer 37:2682-2690, 1976. 7. Weichselbaum RR, Epstein J, and Little JB: In Vitro Radiosensitivity of Human Diploid Fibroblasts Derived from Patients with Unusual Clinical Responses to Radiation. Radiology 121:479-482, 1976. 8. Weichselbaum RR, Epstein AJ, and Little JB: A Technique for Developing Established Cell Lines from Human Osteosarcomas. In Vitro 12: 833-836, 1976. 9. Pitmann SW, Miller D, Weichselbaum RR, Frei E, III: Weekly High Dose Methotrexate with Leucovorin Rescue as Initial Adjuvant Therapy in Advanced Squamous Cell Carcinoma of the Head and Neck: A Pilot Study. In Adjuvant Therapy of Cancer. Salmon SE, and Jones SE (eds), Elsevier/North Holland Biomedical Press Amsterdam (publs.), pps.467-473, 1977. 10. Jaffe N, Murray J, Traggis D, Cassady JR, Filler R, Watts H, Weichselbaum RR, and Weinstein H: Multidisciplinary Treatment for Childhood Sarcoma. Am. J. Surg. 133:405-413, 1977. 11. Weichselbaum RR, Little JB, and Nove J: Response of Human Osteosarcoma In Vitro to Irradiation: Evidence for Unusual Cellular Repair Activity. Int. J. Radiat. Oncol. Biol. Phys. 31:295-299, 1977. 12. Weichselbaum RR, Nove J, and Little JB: Skin Fibroblasts from a D-deletion Type Retinoblastoma Patients are Abnormally X-ray Sensitive. Nature 266:726-727, 1977. 15 13. Weichselbaum RR, Cassady, JR, Filler R, and Jaffe N: The Evolution of Combination Therapy of Genitourinary Rhabdomyosarcoma in Children: A Preliminary Report. Int J. Radiat. Oncol. Biol. Phys. 2:267-272, 1977. 14. Weichselbaum RR, Cassady JR, Jaffe N, and Filler RM: Preliminary Results of Aggressive Multimodality Therapy for Metastatic Osteosarcoma. Cancer 40:78-83, 1977. 15. Weichselbaum RR, Liszczak TM, Phillips JP, Little JB, Epstein J, and Kornblith PL: Characterization and Radiobiologic Parameters of Medulloblastoma In Vitro. Cancer 40:1087-1096, 1977. 16. Svensson GK, Bjarngard BE, Chen GTY, and Weichselbaum RR: Superficial Doses in Treatment of Breast with Tangential Fields Using 4 MV X-rays. Int. J. Radiat. Oncol. Biol. Phys. 2:705-710, 1977. 17. Weichselbaum RR, Marck A, and Hellman S: Pathogenesis of Pleural Effusion in Carcinoma of the Breast. Int. J. Radiat. Oncol. Biol. Phys. 2:963-965, 1977. 18. Pitman SW, Miller D, and Weichselbaum RR: Initial Adjuvant Therapy in Advanced Squamous Cell Carcinoma of the Head and Neck Employing Weekly High Dose Methotrexate with Leucovorin Rescue. Laryngoscope 88:632-638, 1978. 19. Selsky C, Weichselbaum RR, and Little JB: Defective Host Cell Reactivation of UV-irradiated Herpes Simplex Virus by Bloom's Syndrome Skin Fibroblasts. In DNA Repair Mechanisms. Friedberg EC, and Hanawalt PC (eds.), Academic Press (publs). pps. 555-558, 1978. 20. Little JB, Weichselbaum RR, Nove JJ, and Albert D: X-ray Sensitivity of Fibroblasts from Patients with Retinoblastoma and with Abnormalities of Chromosome 13. In DNA Repair Mechanisms. Friedberg EC, and Hanawalt PC (eds.), Academic Press (publs), pps. 685-690, 1978. 21 Sherman DM, Weichselbaum RR, Order SE, Cloud L, Trey C, and Piro AJ: Palliation of Hepatic Metastasis. Cancer 41:2013-2017, 1978. 22. Weichselbaum RR, Nove J, and Little JB: Deficient Recovery from Potentially Lethal Damage in Ataxia Telangiectasia and Xeroderma Pigmentosum. Nature 271:261-262, 1978. 23. Dritschilo A, Weichselbaum RR, Cassady JR, Jaffe N, Green D, and Filler RM: The Role of Radiation Therapy in the Treatment of Soft Tissue Sarcomas of Childhood. Cancer 42: 1192-1203, 1978. 24. Sherman DM, Neptune W, Weichselbaum RR, Order SE, and Piro AJ: An Aggressive Approach to Marginally Resectable Lung Cancer. Cancer 41:2040-2045, 1978. 16 25. Weichselbaum RR, Miller D, Pitman SW, and Kirkwood J: Initial Adjuvant Weekly High Dose Methotrexate with Leucovorin Rescue in Advanced Squamous Carcinoma of the Head and Neck. Int. J. Radiat. Oncol. Biol. Phys. 4:671-674, 1978. 26. Weichselbaum RR, Nove J, and Little JB: X-ray Sensitivity of Diploid Fibroblasts from Patients with Hereditary or Sporadic Retinoblastoma. Proc. Nat. Acad. Sci. USA 75: 3962-3964, 1978. 27. Weichselbaum RR, Hellman S, Piro AJ, Nove JJ, and Little JB: Proliferation Kinetics of a Human Breast Cancer Line In Vitro Following Treatment with 17 Betaestradiol and 1-Beta-D-Arabinofuranosylcytosine. Cancer Res. 38: 2339-2342, 1978. 28. McNeil BJ, Weichselbaum RR, and Paucker SG: Determination of Optimal Therapy. Fallacy of the Five Year Survival in Lung Cancer. New Eng. J. Med. 299:1397-1401, 1978. 29. Weichselbaum RR, and Bruckman JE: Radiation Therapy: Principles and Techniques. In Primer of Cancer Management. Lokich J (ed.), Hall GK, & Co. (publs.) pps. 69-87, 1978. 30. Fornace A, Little JB, and Weichselbaum RR: DNA Repair in a Fanconi's Anemia Fibroblast Cell Strain. Biochem. et Biophys. Acta 561: 99-109, 1979. 31. Weichselbaum RR, Zakov ZN, Albert DM, Friedman AH, Nove J and Little JB: New Findings in Chromosome 13 Long-Arm Deletion Syndrome and Retinoblastoma. Ophthalmology 86:1191-1198, 1979. 32. Kirkwood JM, Miller D, Weichselbaum RR, and Pitman SW: Predefinitive and Postdefinitive Chemotherapy for Locally Advanced Squamous Carcinoma of the Head and Neck. Laryngoscope 89:573-581, 1979. 33. Selsky CA, Hensen P, Weichselbaum RR, and Little JB: Defective Reactivation of Ultraviolet Light-irradiated Herpes Virus by a Bloom's Syndrome Fibroblast Strain. Cancer Res. 30: 3392-3396, 1979. 34. Mauch P, Weichselbaum RR, and Botnick L:The Significance of Positive Chorionic Gonadotropins in Apparently Pure Seminoma of the Testis. Int. J. Radiat. Oncol. Biol. Phys. 5: 887-889, 1979. 35. Nove J, Little JB, Weichselbaum RR, Nichols WW, and Hoffman E: Retinoblastoma, Chromosome 13, and In Vitro Cellular Radiosensitivity: Evidence for Two Distinct Loci in 13q14. Cytogenet.Cell Genet. 24:176-184, 1979. 36. Greenberger JS, Weichselbaum RR, Botnick LE, Sakakeeny M, and Moloney WC: Cell Biological Effects of Total Body Irradiation on Growth and Differentiation of Acute Myelogenous Leukemia Cells Compared to Normal Bone Marrow. Exp. Hematol. 7:279-289, 1979. 17 37. Walker JP, Weiter JJ, Albert DM, Osborn EL, and Weichselbaum RR: Uveal Malignant Melanoma in Three Generations of the Same Family. Am. J. Ophthalmol., 88:723-726, 1979. 38. Weichselbaum RR, Nove J, Hellman S, Piro AJ, and Little JB: Combination Hormonal, Chemotherapy and Radiotherapy In Vitro: Implications for Therapy In Vivo. Int. J. Radiat. Oncol. Biol. Phys. 5:1657-1662, 1979. 39. Weichselbaum RR, and Cassady JR: Radiation Therapy in Osteosarcoma. In Bone Tumors in Children. Eds. N. Jaffe. Publs. PSG Publishing Co., Littleton, MA pps. 183-190, 1979. 40. Ervin TJ, Weichselbaum RR, and Greenberger JS: Radiation Therapy for NonHodgkin's Lymphoma. In Clinics in Hematology. Canellos G, (ed.). Grune and Stratton (publs.), NY. 8:657-666, 1979. 41. Greenberger JS, Come S, and Weichselbaum RR: Issues of Controversy in Radiation Therapy and Combined Modality Approaches to Hodgkin's Disease. In Clinics in Hematology. G. Canellos G (ed.), Grune & Stratton (publs.), NY. 8:611614, 1979. Nichols WW, Miller RC, Hoffman E, Albert D, Weichselbaum RR, Nove J, and Little JB: Interstitial Deletion of Chromosome 13 and Associated Congenital Anomalies. Human Genet. 52:169-173, 1979. 42. 43. Weichselbaum RR, and Little JB: Familial Retinoblastoma and Ataxia Telangiectasia: Human Models for the Study of DNA Damage and Repair. Cancer 45: 775-779, 1980. 44. Weichselbaum RR, Nove J, and Little JB: Radiation Response of Human Tumor Cells In Vitro. In Radiation Biology in Cancer Research. Meyn RE, and Withers HR (eds.). Raven Press (publ.), NY. pps. 345-351, 1980. 45. Weichselbaum RR, Nove J, and Little JB: X-ray Sensitivity of Human Tumor Cells In Vitro. Int. J. Radiat. Oncol. Biol. Phys. 6:437-440, 1980. 46. Weichselbaum RR, Nove J, and Little JB: X-ray Sensitivity of Fifty-three Human Diploid Fibroblast Cell Strains from Patients with Characterized Genetic Disorders. Cancer Res. 40: 920-925, 1980. 47. Little JB, Nove J, and Weichselbaum RR: Abnormal Sensitivity of Diploid Skin Fibroblasts from a Family with Gardner's Syndrome to the Lethal Effects of Xirradiation, Ultraviolet Light and Mitomycin-C. Mut. Res. 70:241-250, 1980. 48. Albert, D. and Weichselbaum, RR, (eds.): International Ophthalmology Clinics. Advances Regarding the Pathogenesis and Treatment of Ocular Tumors. Little Brown Co. (publs.), Boston, MA. 20: #2, 1980. 18 49. Weichselbaum RR, Goebel R, and Lokich JJ: Complications of Radiotherapy and Chemotherapy. In Clinical Cancer Medicine.Hall GK (publs.), Boston, MA, pps.325-354, 1980. 50. Lubin JR, Gragoudas ES, Albert DM, and Weichselbaum RR: Bilateral Malignant Choroidal Melanomas. In International Ophthalmology Clinics: Advances Regarding the Pathogenesis and Treatment of Ocular Tumors. Little Brown & Co. (publs.), Boston, MA. 20:103-115, 1980. 51. Weichselbaum RR, Cassady JR, Albert D, and Gonder JR: Multimodality Management of Orbital Rhabdomyosarcoma. In International Ophthalmology Clinics: Advances Regarding the Pathogenesis and Treatment of Ocular Tumors. Little, Brown & Co. (publs.), Boston MA. 20, 247-259, 1980. 52. Zakov ZN, Cook SA, Albert DM, and Weichselbaum RR: False-Positive Phosphorus 32 Uptake Tests in the Diagnosis of Ocular Melanoma. In International Ophthalmology Clinics: Advances Regarding the Pathogenesis and Treatment of Ocular Tumors. Little, Brown & Co. (publs.), Boston, MA. 20:117-121, 1980. 53. Nove J, Weichselbaum RR, Nichols WW, Albert DM and Little JB: In Vitro Studies of Fibroblasts from Patients with Retinoblastoma. In International Ophthalmology Clinics: Advances Regarding the Pathogenesis and Treatment of Ocular Tumors. Little, Brown, & Co. (publs.), Boston, MA. 20: 211-222, 1980. 54. Kinsella TJ, Weichselbaum RR, and Sheline G: Radiation Injury of Cranial and Peripheral Nerves. In Radiation Injury to the Nervous System: A Delayed Therapeutic Hazard. Raven Press (publs.), NY. pps.143-153, 1980. 55. Weichselbaum RR, Little JB, Nove J, and Hellman S: Lack of Selective Killing by Steroids in Normal and Malignant Cells. J. Cell. Physiol. 103:429-433, 1980. 56. Bloomer WD, McLaughlin WT, Weichselbaum RR, Tonnesen GI, Hellman S, Seitz DE, Hanson RN, Adelstein SJ, Rosner AL, Burstein NA, Nove J, and Little JB: Iodine-125-Labelled Tamoxifen is Differentially Cytoxic to Cells Containing Estrogen Receptors. Int. J. Radiat. Biol. Phys. 38:197-203, 1980. 57. Greenberger JS, Eckner RJ, Ostertag W, Colleta G, Boschetti S, Nagasawa H, Karpas A, Weichselbaum RR, and Moloney WC: Release of Spleen Focus-Forming Virus (SFFV) from Differentiation Inducible Promyelocytic Leukemia Cell Lines Transformed In Vitro by Friend Leukemia Virus. Virology 104:425-435, 1980. 58. West G, Weichselbaum RR, and Little JB: Limited Penetration of Methotrexate into Human Osteosarcoma Spheroids as a Proposed Model for Solid Tumor Resistance to Adjuvant Chemotherapy. Cancer Res. 40:3665-3668, 1980. 59. Weichselbaum RR, Nove J, Albert D, and Little JB: An In Vitro Investigation of Genetic Susceptibility to Cancer in Diploid Fibroblasts from Retinoblastoma Patients. Teratogenesis, Carcinogenesis, Mutagenesis. 1:171-179, 1980. 19 60. Mauch PM, Ryback M, Rosenthal D, Weichselbaum RR, and Hellman S: The Influence of Initial Pathological Stage on the Survival of Patients who Relapse from Hodgkin's Disease. Blood 56:892-897, 1980. 61. Botnick L, Bloomer WD, and Weichselbaum RR: An Alternative to Mastectomy in Operable Breast Cancer: Primary Radiation Therapy. In Controversy in Medical Oncology. Moser VS (ed.), Hall GK (publs.), Boston, MA, pps.18-27, 1981. 62. Richie J, Weichselbaum RR, Greenberger JS, and Marck A: Twice-a-day Fractionated Preoperative Radiotherapy in Patients with Carcinoma of the Bladder. A Preliminary Report. J. Urol. 1252:179-181, 1981. 63. Sherman D, and Weichselbaum RR: The Use of Preoperative Radiation Therapy in the Treatment of Lung Cancer. In: Treatment of Lung Cancer. Livingston RB (eds.), Martinos Nijhott (publs.), Boston, The Hague, pps. 63-73, 1981. 64. Sherman D, Weichselbaum RR, and Hellman S: The Characteristics of Long-term Survivors of Lung Cancer Treated with Radiation. Cancer 47: 2575-2580, 1981. 65. Cox R, Masson WK, Weichselbaum RR, Nove J, and Little JB: The Repair of Potentially Lethal Damage in X-irradiated Cultures of Normal and Ataxia Telangiectasia Human Fibroblasts. Int. J. Radiat. Biol. Phys. 39: 357-365, 1981. 66. Miller D, Ervin T, Weichselbaum RR, and Fabian R: The Differential Diagnosis of the Mass in the Neck: A Fresh Look. Laryngoscope XCI:140-145, 1981. 67. Greenberg H, Goebel RH, Weichselbaum RR, Greenberger JS, Cassady JR, and Chaffey, JT: Radiation Therapy in the Treatment of Aggressive Fibromatosis. Int. J. Radiat. Oncol. Biol. Phys. 7:305-310, 1981. 68. Weichselbaum RR, Greenberger JS, Schmidt A, Karpas A, Moloney W, and Little JB: In Vitro Radiosensitivity of Human Leukemia Cell Lines. Radiology 139: 485487, 1981. 69. Kennedy AR, and Weichselbaum RR: Effects of 17B Estradiol on Radiation Transformation In Vitro: Inhibition of Effects by Protease Inhibitors. Carcinogenesis 2: 67-69, 1981. 70. Kirkwood J, Canellos G, Ervin TJ, Pittman S, Weichselbaum RR, and Miller D: Increased Therapeutic Index using Moderate Dose Methotrexate and Leucovorin Twice Weekly vs. Weekly High Dose Methotrexate Leucovorin in Patients with Advanced Squamous Carcinoma of the Head and Neck: A Safe New Effective Regimen. Cancer 47: 2414-2422, 1981. 20 71. Ervin TJ, Kirkwood J, Weichselbaum RR, Miller D, Pittman DW, and Frei E: Improved Survival for Patients with Advanced Carcinoma of the Head and Neck Treated with Methotrexate-Leucovorin Prior to Definitive Radiotherapy or Surgery. Laryngoscope 91: 1181-1190, 1981. 72. Bloomer WD, Botnick LE, and Weichselbaum RR: Primary Radiation Therapy for Operable Breast Cancer. In Surgical Oncology; Controversies in Cancer Treatment. O'Connel TX (eds.), Hall GK Medical Publs., Boston, MA, pps.3-15, 1981. 73. Weichselbaum RR, Rheinlander R, and Piro AJ: The Management of Lung Carcinoma by Surgery and Radiation Therapy. In: Principles of Cancer Treatment. Carter, S.K., Glatstein E, and Livingston RB (eds), McGraw Hill (publs.), St. Louis, MO, pps.359-366, 1981. 74. Ervin TJ, Miller D, Weichselbaum RR, Fabian RL, Meshad MM: Chemotherapy for Advanced Carcinoma of the Head and Neck. A Clinical Update. Arch. Otolaryngol. 107: 237-241, 1981. 75. Bloomer WD, McLaughlin WH, Weichselbaum RR, Hanson RN, Adelstein SJ, and Seitz DE: The Role of Subcellular Localization in Assessing the Cytotoxicity of Iodine-125 Labelled Iododeoxyuridine, Iodotamoxifen and Iodoantipyrine. J. Radioanal. Chem. 65: 209-221, 1981. 76. Ervin TJ, Karp DD, Weichselbaum RR, and Frei E, III: Adjuvant Chemotherapy for Squamous Cell Carcinoma of the Head and Neck. In Adjuvant Therapy of Cancer III. Salmon SE, and Jones S (eds.). Grune & Stratton (publs.), pps. 183-189, 1981. 77. Nove J, Nichols WW, Weichselbaum RR, and Little JB: Abnormalities of Chromosome 13 and In Vitro Radiosensitivity: A Study of Nineteen Fibroblast Strains. Mut. Res.84: 157-167, 1981. 78. Ervin TJ, Karp DD,Weichselbaum RR, Posner MR, Fabian RL, and Miller D: The Role of Chemotherapy in the Multidisciplinary Approach to Advanced Head and Neck Cancer: Potentials and Problems. Ann. Otol. Rhinol. Laryngol. 90:506511,1981. 79. Ervin TJ, Karp DD, Weichselbaum RR, Miller D, Meshad MM, Posner MR, and Fabian RL: Treatment of Advanced Squamous Cell Carcinoma of the Head and Neck with Cis-platinum, Bleomycin and Methotrexate (PBM). Cancer Treat. Rep.65: 787791, 1981. 80. McNeil BJ, Weichselbaum RR, and Pauker S: Speech and Survival: Tradeoffs Between Quality and Quantity of Life in Laryngeal Cancer. New Eng. J. Med. 305:982-987, 1981. 81. Kennedy AR, and Weichselbaum RR, : Effects of Dexamethasone and Cortisone with X-irradiation on Transformation of C3H 10T 1/2 Cells. Nature 294:97-98, 1981. 21 82. Richie JR, Weichselbaum RR, Malcolm A, and Little JB: Short Course High Dose Radiation Therapy: An In Vitro Radiobiologic Study. Surgical Forum II:pps.609-611, 1981. 83. Gordon W, Antman KH, Greenberger JS, Weichselbaum RR, and Chaffey JT: Radiation Therapy in the Management of Patients with Mesothelioma. Int. J. Radiat. Oncol. Biol. Phys. 8: 19-25, 1982. 84. Richie J, Weichselbaum RR, and Little JB: Importance of Repair of Potentially Lethal Damage in Assays of Cytotoxic Agents. Surgery 92:380-384, 1982. 85. Kinsella T, Little JB, Nove J, Weichselbaum RR, Li FP, Meyer R, Marchetta D, and Patterson BW: Heterogenous Response to X-ray and UV Light Irradiations of Cultured Skin Fibroblasts in Two Families with Gardner's Syndrome. J. Nat. Cancer Inst. 68: 697-701, 1982. 86. Weichselbaum RR, Malcolm A, and Little JB: Fraction Size and the Repair of Potentially Lethal X-ray Damage in a Human Melanoma Cell Line: Possible Implications for Radiotherapy. Radiology 142: 225-227, 1982. 87. Weichselbaum RR, Schmit A, and Little JB: Cellular Repair Factors Influencing Radiocurability of Human Malignant Tumors. Brit. J. Cancer 45: 10-16, 1982. 88. Chess J, Ni C, Yin KQ, Wang WJ, Cassady JR, Weichselbaum RR, and Albert D: Rhabdomyosarcoma In:Tumors of the Eyelid and and Orbit. A Chinese Collaborative Study. Little, Brown, & Co. (publs.), Boston, MA, pps.163-182, 1982. 89. Schwartz J, Solt DB, Pappo J, and Weichselbaum RR: Distribution of Langerhans Cells in Normal and Carcinogen Treated Mucosa of Buccal Pouches of Hamsters. J. Dermatol. Oncol. 17: 1005-1010, 1982. 90. Greenberger JS, Weichselbaum RR, and Cassady JR: Radiation Nephropathy. In Cancer and the Kidney. Rieselbach RE, and Garnick. M (eds.), Lea and Feiberger (publs.), pps.814-823, 1982. 91. Weichselbaum RR, Malcolm A, and Little JB: Recovery from X-ray Damage in Plateau Phase Human Tumor Cells. In: Progress in Radio-Oncology II. Karcher KH, et al. (eds.), Raven Press (publs.), NY, pps.309-316, 1982. 92. Weichselbaum RR, Posner MR, Ervin TJ, Fabian RL, and Miller D: Toxicity of Aggressive Multimodality Therapy Including Cisplatinum, Bleomycin and Methotrexate with Radiation and/or Surgery for Advanced Head and Neck Cancer. Int. J. Radiat. Oncol. Biol. Phys. 8:909-913, 1982. 93. Weichselbaum RR, Ervin TJ, and Miler D: Chemical Modulation of the Hypoxic Fraction in the Treatment of Head and Neck Cancer. Ann. Otol. Rhinol. Laryngol. 91:461-464, 1982. 22 94. Umans R, Weichselbaum RR, Johnson C, and Little JB: Effects of Serum Free Defined Medium on MCF-7 Cell Nuclear Estrogen-Receptor Levels. J. Mol. Cell. Endocrin. 28:91-98, 1982. 95. Weichselbaum RR and Little JB: Radioresistance in Some Human Tumor Cells Conferred In Vitro by Repair of Potentially Lethal X-ray Damage. Radiology 145: 511-513, 1982. 96. Weichselbaum RR and Little JB: Repair of Potentially Lethal X-ray Damage and Possible Applications to Clinical Radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 9: 91-96, 1982. 97. Weichselbaum RR and Little JB: The Differential Response of Human Tumors to Fractionated Radiation May be due to a Post-Irradiation Repair Process. Brit. J.Cancer 46: 532-537, 1982. 98. Posner MR, Ervin TJ, Weichselbaum RR, Fabian RL, and Miller D: Chemotherapy of Advanced Salivary Gland Neoplasms. Cancer 50:2261-2264, 1982. 99. Schwartz J, Weichselbaum RR, and Horton J: Tooth Eruption in the Microphthalmic Mouse Following Adaptive Transfer of Peritoneal Derived Macrophages. In Excerpta Medica. Current Advances in Skeletogenesis. Proceedings of the Fifth International Workshop on Calcified Tissues. M. Silberman M, and Slavkin H (eds.), pps.290-297, 1982. 100. Bloomer WD, McLaughlin W, Milius S, Weichselbaum RR, and Adelstein S: Estrogen Receptor Mediated Cytotoxicity Using I[I125]. J. Cell Bio. Chem.21:39-45, 1983. 101. Weichselbaum RR, Withers HR, Tomkinson KT, and Little JB: Potentially Lethal Damage Repair in X-irradiated Cultures of a Normal Human Diploid Cell Strain. Int. J. Radiat. Oncol. Biol. Phys. 43:313-320, 1983. Schwartz J, Weichselbaum RR, and Frim S: The Effect of Aging on the Density and Distribution of Oral Mucosal Langerhans Cells. Exp. Gerentol.18:65-71, 1983. 102. 103. Weichselbaum RR, and Little JB: The Role of Potentially Lethal Damage Repair in Human Tumor Radiocurability. In The Biological Basis and Clinical Implications of Tumor Clinical Resistance. Nervi C, Mauro F, and Archangeli G (eds.). Proceedings of the 2nd Rome Internat. Symp., Rome, Italy, Masson (publs.), NY. 19-23. 1983. 104. Weichselbaum RR, and Elkind MM: Contributions of the Discussion Initiators: In: The Biological Bases and Clinical Implications of Tumor Clinical Resistance. Nervi C, Mauro F, and Archangeli G (eds.). Proceedings of the 2nd Rome International Symposium, Rome, Italy. Mason (publs.), NY, 43-44, 1983. 105. Griem K, Weichselbaum RR, Umans R, Gifford L, and Little JB: Radioprotection of Human Breast Cancer Cells by Elevation of Intracellular Cyclic AMP. Radiology 148: 289-290, 1983. 23 106. Weichselbaum RR, and Hellman S: Basic Principles of Radiation Oncology. In: Textbook of Surgical Oncology. Pilich Y (ed.), McGraw Hill (publs.), pps. 176-197, 1983. 107. Posner MR, Weichselbaum RR, Carroll E, Fabian RL, Miller D, and Ervin TJ: Small Cell Carcinomas of the Larynx: Results of Combined Modality Treatment. Laryngoscope 93(7): 946-948, 1983. 108. Weichselbaum RR, and Sherman, D.: Treatment of Advanced Breast Cancer (with Historical and Annotated Bibliography). In Modern Radiation Oncology Classics II. Gilbert H. (ed.), Williams and Wilkins (publs.), Baltimore, MD, pps. 114-129, 1983. 109. Sherman D, and Weichselbaum RR: Treatment of Hepatic Metastasis (with Historical and Annotated Bibliography). In Modern Radiation Oncology Classics II. Gilbert H (ed.), Williams and Wilkins (publs.), pps. 451-473, 1983. 110. Weichselbaum RR, Albert D, Cassady JB, Little JB: An In Vitro Investigation of Xray Sensitivity in Fibroblasts from Patients with Retinoblastoma. Invest. Ophthalmol. Visual Sci. 24: 958-961, 1983. 111. Weichselbaum RR, and Little JB: X-ray Sensitivity and Repair in Human Tumor Cells. In The Biological Basis of Radiotherapy. Steele G, Adams G, and Peckman M, (eds.), Elsevier Science (publs.) B.V., London. pps.113-122, 1983. 112. Weichselbaum RR, and Little JB: The Heterogeniety in Response of Human Tumor Cells to X-irradiation In Vitro . In: Radioprotectors andd Anticarcinogens. Nygaard O, and Simic M, (eds.). Academic Press (publs.), NY, pps. 607-613, 1983. 113. Key L, Carnes D, Weichselbaum RR, and Anast C: Platelet-derived Growth Factor Stimulates Bone Resorption by Monocyte Monolayers. Endocrinology 112: 761-762, 1983. Weichselbaum RR, Nichols WW, Albert D, and Little JB: In Vitro Radiosensitivity of Fibroblasts Derived from Patients with Retinoblastoma and Abnormalities of Chromosome- 13. Retina 3:126-130, 1983. 114. 115. Weichselbaum RR, Rose CM, Ervin TJ, and Miller D: Radiobiologic Research for Head and Neck Cancer Therapy. Arch. Otolaryngol.109:792-796, 1983. 116. Mauch PM, Greenberg H, Lewin A, Cassady JR, Weichselbaum RR, and Hellman S: Prognostic Factors in Patients with Subdiaphragmatic Hodgkin's Disease. Hematol. Oncol.1: 205-214, 1983. 117. Richie JP, Weichselbaum RR, Dahlberg W, and Little JB: Effects of Ionizing Radiation on Human Bladder Cell Lines. An In Vitro Radiobiologic Study. Surg.Forum XXXIV. pps. 674-675, 1983. 24 118. Odukoya O, Schwartz J, Weichselbaum RR, and Shklar G.: An Epidermoid Carcinoma Cell Line Derived from Hamster 7, 12-Dimethylbenz [a] Anthraceneinduced Buccal Pouch Tumors. J. NCI 71: 1253-1258, 1983. 119. Weichselbaum RR: Seminoma. In Urologic Cancer, a Multi-disciplinary Perspective. Garnick M, and Richie J, (eds.), Plenum Medical Book Co. (publs.), pps.155-162, 1983. 120. Ervin TJ, and Weichselbaum RR: The Role of Methotrexate in Head and Neck Cancer. In The Chemotherapy of Breast, Gastrointestinal, and Head and Neck Cancer: Current Status and Potential Role of Methotrexate and Fluorouracil. Bertino JR, and Henderson IJ (eds.), Pharma. Libr., Short Hill (publs.), NJ, pps.59-79, 1983. 121. Weichselbaum RR, Sherman DM, and Ervin TJ: Basic Principles of Radiotherapy. In Oral Cancer. Sklar G (ed.), W.B. Saunders Publishing Co. (publs.), 1119-126, 1984. 122. Ervin TJ, Karp D, and Weichselbaum RR: Chemotherapy for Advanced Oral Cancer. In Oral Cancer. Shklar G (ed.), W.B. Saunders Publishing Co. (publs.) pps.179-185, 1984. 123. Umans R, Weichselbaum RR, Johnson CM, and Little JB: Effects of Estradiol Concentration on Levels of Nuclear Estrogen Receptors in MCF-7 Breast Tumor Cells. J. Steroid Biochem 20: 605-609, 1984. 124. Guichard M, Weichselbaum RR, Little JB, and Malaise EP: Potentially Lethal Damage Repair as a Possible Determinant of Human Tumor Radiosensitivity. Radiother. Oncol. 1: 263-269, 1984. 125. Weichselbaum RR, and Marck A: Radiotherapy in the Treatment of Breast Cancer: Radiation Therapy as Primary Treatment. In Caring for the Patient with Breast Cancer: An Inter/Multidisciplinary Approach. Mulliken JB, and Pfeiffer C (eds.), Publs. Reston Publs. Co. (publs.), Prentice Hall, pps.103-125, 1984. 126. Weichselbaum RR and Marck A: Palliative Radiotherapy: Palliative Radiotherapy in the Treatment of Breast Cancer. In Caring for the Patient with Breast Cancer: An Inter/Multidisciplinary Approach. Mulliken JB, and C. Pfeiffer C (eds.). Reston Publs. Co (publs.)., Prentice Hall, pps. 137-145, 1984. 127. Albert D, McGhee C, Seddon CNJ, and Weichselbaum RR: Development of Additional Primary Tumors After 62 Years in the First Patient with Retinoblastoma Cured by Radiation Therapy. Am. J. Ophthal.97: 189-196, 1984. 128. Ervin TJ, Weichselbaum RR, Fabian RL, Miller D, Norris CM, Posner M, Rose C, Lockhart P, Tuttle S, MacIntyre JM, and Frei E: Advanced Squamous Carcinoma of the Head and Neck. A Preliminary Report of Neoadjuvant Chemotherapy with Cisplatinum, Bleomycin and Methotrexate. Arch. Otolaryngol. 10: 241-245, 1984. 25 129. Posner MR, Ervin TJ, Miller D, Fabian RL, Norris CM, Weichselbaum RR, and Rose C: Incidence of Hypothyroidism following Multimodality Treatment for Advanced Squamous Cell Cancer of the Head and Neck. Laryngoscope 94: 451-454, 1984. 130. Ervin TJ, Weichselbaum RR, Miller D, Posner MR, Fabian RL, Rose C, and Norris, Jr., CM: The Role of Chemotherapy for Advanced Carcinoma of the Supraglottic and Glottic Larynx. Otolaryngol. Clin. No. Amer., 209-214, 1984. 131. Richie J, and Weichselbaum RR: Integrated Irradiation and Cystectomy for Bladder Cancer. In Bladder Cancer. Javadpour N (ed.), Williams & Wilkins (publs.), Baltimore, MD, pps. 179-189, 1984. 132. Dryja T, Rapaport JM, Weichselbaum RR, and Bruns G: Chromosome 13 Restriction Fragment Length Polymorphisms. Human Genet. 65: 320-324, 1984. 133. Weichselbaum RR, Dahlberg W, Little JB, Ervin T, Miller D, Hellman S, and Rheinwald J: Cellular X-ray Repair Parameters of Early Passage Squamous Cell Carcinoma Lines Derived from Patients with Known Responses to Radiotherapy. Br. J. Cancer. 49: 595-601, 1984. 134. Kufe D, Weichselbaum RR, Egan M, Dahlberg W, and Framm, R.: Lethal Effects of 1-betta-D-arabinofuranosylcytosine incorporation into deoxyribonucleic acid during ultraviolet repair: Mol. Pharmacol. 25: 322-326, 1984. 135. Brock WA, Williams D, McManey C, Milas L, Peters CJ, and Weichselbaum RR: Modification by Dexamethaone of Radiation Response of In Vitro Cultured Cells. Int. J. Radiat. Oncol. Biol. Phys. 10: 2113-2117, 1984. 136. Weichselbaum RR: The Role of DNA Repair Processes in the Response of Human Tumors to Fractionated Radiotherapy. Int. J. Radiat. Oncol. Biol. Phys.110(7): 112734, 1984. 137. Schwartz JL, and Weichselbaum RR: The Mechanism of 3 Aminobenzamidemediated Increases in Spontaneous and Induced SCE's. In Sister Chromatid Exchanges. Tice RR, and Hollaender A. (eds.), Plenum Publishing Corp. 293-304, 1984. 138. Imperato JP, Weichselbaum RR, and Ervin TJ: The Role of Post-operative Radiation Therapy in the Treatment of Malignant Tumors of the Parotid Gland. J. Surg. Oncol. 27: 163-167, 1984. 139. Weichselbaum RR, Little JB, Tomkinson K, Evans S, and Yuhas J: Repair of Fractionated Radiation in Plateau Phase Cultures of Human Tumors and Human Multicellular Tumor Spheroids. Radiother. Oncol. 2131: 41-47, 1984. 140. Dritschilo A, Brennan T, Weichselbaum RR, Mossman, KL: Response of Human Fibroblasts to Low Dose Gamma Radiation. Rad. Res. 100: 387-395, 1984. 26 141. Umans R, Weichselbaum RR, Johnson C, Kennedy AR: Protease Inhibitor Antipain Reduces Nuclear Binding of Estrogen Receptor Complex in MCF-7 Cells. Carcinogen. 5: 1355-1357, 1984. 142. Ervin TJ, Weichselbaum RR, and Posner MR: The Evolution of Chemotherapy in Head and Neck Cancer. Oncologia 220: 33-37, 1984. 143. Ervin TJ, and Weichselbaum RR: Treatment of Advanced Squamous Carcinoma of the Head and Neck: The Sidney Farber Cancer Center Institute-Joint Center for Radiation Therapy Experience. Oncologia 220: 75-78, 1984. 144. Yuhas J, Blake S, and Weichselbaum RR: Quantification of the Response of Human Tumor Spheroids to Daily Radiation Exposures. Int. J. Radiat. Oncol. Biol. Phys.10: 2323-2327, 1984. 145. Weichselbaum RR, and Ervin TJ: Radiobiological Factors Influencing Fractionation in Head and Neck Therapy. In Head and Neck Cancer. Chretien P, and Shedd D, (eds.), Decker BC, Inc. (publs.), Vol.1, pps. 331-332, 1985. 146. Weichselbaum RR, Clarke J, Miller D, Posner MR, and Ervin TJ: Combined Modality Treatment of Head and Neck Cancer with Induction Cisplatinum, Bleomycin, Methotrexate, Leucovorin Chemotherapy. Cancer 55; 2149-2155, 1985. 147. Weichselbaum RR, Clarke J, Miller D, Posner MR, Chaffey JT, Fabian R, Norris C, Fitzgerald TJ, Rose C, and Ervin TJ.: Combination Treatment of Head and Neck Cancer with Induction Chemotherapy. In Head and Neck Cancer. Chretien P, and Shedd D,(eds.), Decker BC, Inc. (publs.), pps.443-449, 1985. 148. Loeffler J, Larson D, Clarke J, Weichselbaum RR, Norris C, Ervin TJ: Treatment of Perineural Metastasis from Squamous Carcinoma of the Skin with Aggressive Combination Chemotherapy and Radiation. J. Surg. Oncol. 29: 181-183, 1985. 149. Ervin TJ, Weichselbaum RR, Clark JR, and Boheim K: Rationale for Combination Chemotherapy as Treatment of Advanced Head and Neck Cancer. In Head and Neck Cancer. Chretien P, and Shedd D (eds.), Decker BC, Inc. (publs.), Vol.1, pps.427429, 1985. 150. Weichselbaum RR, Tomkinson K, Little JB: Repair of Potentially Lethal X-ray Damage in fibroblasts derived from patients with hereditary and D-deletion Retinoblastoma: Cell Strains. Int. J. Radiat. Biol. Relat Stud Phys. Chem Med. 47(4):445-446, 1985. 151. Schwartz JL, and Weichselbaum RR: Cytogenetic, Cytotoxic and Cell Cycle Effects of 3-Aminobenzamide in Human Lymphoblastoid Cells Proficient or Deficient in Human Nucleotide Biosynthesis. In ADP-Ribosylation of Proteins. Althaus FR, Hilz H, and Shall S (eds.), Springer-Verlag Inc. (publs.), NY, pps. 332-336, 1985. 27 152. Schwartz JL and Weichselbaum RR: Similar Sensitivity of Human Lymphoblastoid Cells Proficient and Deficient in Nucleotide Biosynthesis to the Cytotoxic and Cell Cycle Effects of 3-Aminobenzamide. Exp. Cell. Res. 157: 271-275, 1985. 153. Schwartz JL, Morgan WF, Brown-Lindquist P, Afzel V, Weichselbaum RR, and Wolff S: Comutagenic Effects of 3-Aminobenzamide in Chinese Hamster Ovary Cells. Cancer Res. 45: 1556-1559, 1985. 154. Schwartz JL, Morgan WF, and Weichselbaum RR: Different Efficiencies of Interaction Between 3-Aminobenzamide and Various Monofunctional Alkylating Agents in the Induction of Sister Chromatid Exchange. Carcinogenesis 6: 699-704, 1985. 155. Schwartz JL and Weichselbaum RR: Antipain-mediated Suppression of Sister Chromatid Exchanges Induced by Inhibitors of Poly (ADP-ribose) Polymerase. Environ. Mutagen. 7: 703-709, 1985. 156. Schwenn M, Weichselbaum RR, and Little JB: Investigation of the Cytotoxic Effects of DNA Damaging Agents on Neurofibromatosis Cells. Mut. Res.142: 55-58, 1985. 157. Posner M, Weichselbaum RR, Fitzgerald TS, Clark J, Rose C, Fabian R, Norris C, Miller D, Tuttle S, and Ervin TJ: Treatment Complications After Sequential Combination Chemotherapy and Radiotherapy with or without Surgery in Previously Untreated Squamous Cell Carcinoma of the Head and Neck. Int. J. Radiat. Oncol. Biol. Phys. 11: 1887-1893, 1985. 158. Weichselbaum RR, Dahlberg W, and Little JB: Inherently Radioresistant Cells Exist in Some Human Tumors. Proc. Nat. Acad. Sci. 82: 4732-4735, 1985. 159. Yuhas JM, Labs LM, Sasaki H, and Weichselbaum RR: In Vitro Models of Human Breast Cancer. Reviews on Endocrine Related Cancer. Suppl. 14, pps.93-99, 1985. 160. Ervin TJ, Clark J, and Weichselbaum RR: Chemotherapy in the Treatment of Squamous Cell Carcinoma of the Head and Neck. Current Concepts in Oncology. Fall, pps.10-17, 1985. 161. Ervin TJ, Miller D, and Weichselbaum RR: Clinical Monograph Squamous Cell Carcinoma of the Piriform Fossa: Multimodality Therapy. Bristol Meyers Oncology Div. (publs.), Syracuse, NY, 1985. 162. Little JB, Nagasawa H, Weichselbaum RR, Lovet DR, Schmit A, Kochenberger JR, and Blumberg P: Differing Patterns of Cytotoxicity of the Phorbol Ester 12-0tetradecanoylphorbol 13-Acetate in Various Human Cell Strains. Carcinogenesis 6:(12), 1703-1708, 1985. 28 163. Ervin TJ, Clark JR, and Weichselbaum RR: Multidisciplinary Treatment of Advanced Squamous Carcinoma of the Head and Neck. Oncologia, Vol. VII 249, (5) 75-78, 1985. 164. Hayes D, Lechan R, Posner M, Weichselbaum RR, Miller D, and Ervin TJ: Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Induction Chemotherapy of Squamous Cell Carcinoma of the Head and Neck. J. Surg. Oncol. 32: 1509-1520, 1986. 165. Greenberger JS, Fitzgerald TJ, Rosenstein L, Pierce J, Sakakeeny MA, Weichselbaum RR, Naperstek E, Newburger D, Griffin J, Bast R, Key L, and Dougherty C: Long-term Culture of Human Granulocytes and Granulocyte Progenitor Cells. In Transfusion Medicine; Recent Techniques. pps. 159-185, 1986. 166. Dryja TP, Rapaport TM, Epstein J, Goorin AM, Weichselbaum RR, Koufos A, and Cavanee WK: Chromosome 13 Homozygosity in Osteosarcoma without Retinoblastoma. Am. J. Genet. 38: 59-66, 1986. 167. Vokes E, Moran WJ, Shilsky RL, Lester EP, Bitran JD, Sutton HG, Hazel ME, Solarski AN, Knapp BA, Weichselbaum RR, and Panje WR: Intensive Induction Chemotherapy for Locally Advanced Head and Neck Cancer: Preliminary Results. In Neoadjuvant Chemotherapy. First Internat. Congress. Jacquillat C, Weil M, Khayat D, (eds.), Colleque INSERM/John Libbey Eurotext, Ltd. (publs.), London, France, Vol. 137: pps.395-401, 1986. 168. Albert DA, Walton DS, Weichselbaum RR, Cassady JR, Little JB, Leombruno D, Trantravahi R, and Puliafito CA: Fibroblast Radiosensitivity and Intraocular Fibrovascular Proliferation Following Radiotherapy for Bilateral Retinoblastoma. Brit. J. Ophthalmol. 70: 336-342, 1986. 169. Weichselbaum RR: Radioresistant and Repair Proficient Cells May Determine Radiocurability in Human Tumors. Int. J. Radiat. Oncol. Biol. Phys. 12: 637-639, 1986. 170. Weichselbaum RR, Dahlberg W, Beckett M, Karrison T, Miller D, Clark J, and Ervin TJ: Radiation-resistant and Repair-proficient Human Tumor Cells may be Associated with Radiotherapy Failure in Head and Neck Cancer Patients. Proc. Nat. Acad. Sci. 83:2684-2688, 1986. PMCID: PMC323364. 171. Ervin TJ and Weichselbaum RR: Multidisciplinary Treatment of Advanced Squamous Carcinoma of the Head and Neck. Oncology 43: 17-20, 1986. 172. Awan AM, Weichselbaum RR, and Addington W, III: Radiation Pneumonitis. In Current Therapy of Respiratory Disease-2, Cherniack RM (ed.), Decker BC, (publs.) pps.183-187, 1986. 29 173. Tarbell NJ, and Weichselbaum RR: Basic Principles of Radiobiology. In Head and Neck Management of the Cancer Patient. Peterson et al. (eds.), Martinus Nijhoff Publishing, pps.77-82, 1986. 174. Weichselbaum RR: Radioresistance and Repair of X-ray Damage in Human Tumors May Be an Important Factor in Predictive Assays for Radiotherapy. In Neue Aspekte Radiologischer Diagnostik und Therapie. Bessler W, Winterthur AB, Bisch f-Delaloye, Luasanne, Hessler C, Lausanne UM, Lutolf, St.Gallen (eds.).Verlag Hans Huber (publs.), Bern, Stuttgart, Toronto, pps. 227-235, 1987. 175. Ervin TJ, Clark JR, Weichselbaum RR, Fallon BG, Miller D, Fabian RL, Posner MR, Norris CM, Tuttle SA, Price KN, and Frei E, III: An Analysis of Induction and Adjuvant Chemotherapy in the Multidisciplinary Treatment of Squamous Cell Carcinoma of the Head and Neck. J. Clin. Onc. 5: 10-20, 1987. 176. Holden SA, Teicher BA, Boheim K, Weichselbaum RR, Ervin TJ: Platinum Complexes Inhibit Repair of Potentially Lethal Damage following Bleomycin Treatment. Brit. J. Cancer 55: 245-248, 1987. 177. Billings PC, Weichselbaum RR, and Kennedy AR: Expression and Methylation of the Blym Gene in Human Tumor Cell Lines. Eur. J. Cancer Clin Oncol. 23:(3)331337, 1987. 178. Weichselbaum RR and Beckett MA: The Maximum Recovery Potential of Human Tumor Cells May Predict Clinical Outcome in Radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 13: 709-713, 1987. 179. Chen GTY, Pelizzari C, Spelbring D, Awan A, and Weichselbaum RR: Evaluation of Lung Treatment Plans with Dose Volume Histograms. In The Use of Computers in Radiotherapy. Bruins vis IAD, et al. (eds.) Elseveier Science Publishers, B.V., North Holland, pps. 165-168, 1987. 180. Jacobs RH, Awan A, Bitran JD, Hoffman PC, Little AG, Ferguson MK, Weichselbaum RR, and Golomb HM: Prophylactic Cranial Irradiation in Adenocarcinoma of the Lung: A Possible Role. Cancer 59: 2016-2019, 1987. 181. Kasid V, Peifer A, Weichselbaum RR, Dritschilo A, and Mark G: The Raf Oncogene is Associated with a Radiation-resistant Human Laryngeal Cancer. Science 237: 1039-1041, 1987. 182. Schwartz J, Giovanazzi S, and Weichselbaum RR: Recovery from Sublethal and Potentially Lethal Damage in an X-ray Sensitive CHO Cell. Rad. Res. 111: 58-67, 1987. 183. Farah R, Ultmann J, Golomb H, Griem M, Desser R, Blough R, and Weichselbaum RR: Extended Mantle Radiation Therapy for Pathologic Stage I and II Hodgkin's Disease. J. Clin. Oncol. 6: 1047-1052, 1988. 30 184. Vokes E, Moran G, Awan A, Schilsky R, Goldman M, Sutton HG, Weichselbaum RR, and Panje W.: Sequential Administration of Methotrexate Cisplatin and 5Fluorouracil in Multimodal Therapy for Locally Advanced Head and Neck Cancer. JNCI Mono., pps. 353-356, 1988. 185. Weichselbaum RR, Beckett MA, Dahlberg W, and Dritschilo A: Heterogeneity of Radiation Response of a Parent Human Epidermoid Carcinoma Cell Line and Four Clones. Int. J. Radiat. Oncol. Biol. Phys. 14: 907-912, 1988. 186. Ervin TJ, Karp DD, and Weichselbaum RR: Chemotherapy and the Oral Cavity. In Guide to Dental Problems for Physicians and Surgeons. Thaller SR, and Montgomery WW (eds.), Williams and Wilkins (publs.), Baltimore, MD, 18: 279286, 1988. 187. Weichselbaum RR, Beckett MA, and Diamond A: Some Retinoblastomas, Osteosarcomas, and Soft Tissue Sarcomas May Share a Common Etiology. Proc. Natl. Acad. Sci.85: 2106-2109, 1988. 188. Vokes EE, Panje WR, Weichselbaum RR, Schilsky RL, Moran WJ, Awan AM, Guarnieri CM: Concomitant Hydroxyurea, 5-Fluorouracil and Radiation Therapy for Recurrent Head and Neck Cancer: Early Results. Otolaryngol. Head & Neck Surg. 98:295-298, 1988. 189. Bitran J, Golomb H, Little A, and Weichselbum RR (Eds.) Lung Cancer - A Comprehensive Treatise. Grune & Stratton Inc., Philadelphia, PA and Harcourt Brace Jovanovich Publishers, 1988. 190. Weichselbaum RR, and Awan AM: Principles of Radiation Oncology: In Lung Cancer-A Comprehensive Treatise. Bitran J, Golomb H, Little A, and Weichselbaum RR (eds.), Grune & Stratton, Inc., Philadelphia, PA, and Harcourt Brace Jovanovich Publishers, pps. 61-70, 1988. 191. Awan AM, Weichselbaum RR and Chen GTY: Radiation Therapy in Stage I Nonsmall Cell Lung Cancer. In Lung Cancer-A Comprehensive Treatise. Bitran J, Golomb H, Little A, and Weichselbaum RR (eds.), Grune & Stratton, Inc. Philadelphia, PA, and Harcourt Brace Jovanovich Publishers, pps.149-157, 1988. 192. Awan AM, and Weichselbaum RR: The Role of Radiation Therapy in Stage IIIM1 Non-small Cell Lung Cancer. In Lung Cancer-A Comprehensive Treatise. Bitran J, Golomb H, Little A, and Weichselbaum RR (eds.), Grune & Stratton, Inc. Philadelphia, PA, and Harcourt Brace Jovanovich Publishers, pps. 243-253, 1988. 193. Bitran J, Little A, Golomb H, and Weichselbaum RR: The Multimodality Approach to Lung Cancer. In Lung Cancer-A Comprehensive Treatise. Bitran J, Golomb H, Little A, and Weichselbaum RR (eds.), Grune & Stratton, Inc. Philadelphia, PA, and Harcourt Brace Jovanovich Publishers, pps.3-4, 1988. 31 194. Scher N, Poe D, Kuchnir F, Reft C, Weichselbaum RR, and Panje WR: Radiotherapy of the Resected Mandible following Stainless Steel Plate Fixation. Laryngoscope 98: 561-563, 1988. 195. Key L, Weichselbaum RR, and Carnes DL: A Link Between Calcitorial and Bone Resorption. Bone and Mineral 3: 201-209, 1988. 196. Vokes E, Choi KE, Schilsky RL, Moran WJ, Guarnieri CM, Weichselbaum RR and Panje WR: Cisplatin, Fluorouracil and High Dose Leucovorin for Recurrent Metastatic Head and Neck Cancer. J. Clin. Oncol. 6: 618-626, 1988. 197. Schwartz JL, Rotmensch J, Beckett MA, Jaffe DR, Toohill M, Giovanazzi SM, McIntosh J, and Weichselbaum RR: X-ray and Cis-Diamminedichloroplatinum (II) Cross-Resistance in Human Tumor Cell Lines. Cancer Res. 48: 5133-5135, 1988. 198. Ackland SP, Schilsky RL, Beckett MA, and Weichselbaum RR: Synergistic Cytotoxicity and DNA Strand Break Formation by Bromodeoxyuridine and Bleomycin in Human Tumor Cells. Cancer Res. 48: 4244-4249, 1988. 199. Weichselbaum RR, Beckett MA, Schwartz JL, and Dritschilo A: Radioresistant Tumor Cells are Present in Head and Neck Carcinomas that Recur after Radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 15: 575-579, 1988. 200. Kolker J, and Weichselbaum RR: Brain Tumor Radiobiology. In Advances in Neuro Oncology. Kornblith PL, and Walker MD (eds), Futura Publishing Co., Mount Kisco, NY, pps.327-346, 1988. 201. Weichselbaum RR, Beckett MA, Simon MA, McCauley C, Haraf D, Awan A, Samuels B, Nachman J, Dritschilo A: In Vitro Radiobiological Parameters of Human Sarcoma Cell Lines. Int. J. Radiat. Oncol. Biol. Phys.15: 937-942, 1988. 202. Schwartz JL, Rotmensch J, Giovanazzi S, and Weichselbaum RR: Faster Repair of DNA Double-strand Breaks in Radioresistant Human Tumor Cells. Int. J. Radiat. Oncol. Biol. Phys.15: 907-912, 1988. 203. Vokes EE, Bitran JD, Hoffman PC, Golomb HM, Weichselbaum RR, Brown CM, Little AG, Fullem L, and Golick JA.: Neoadjuvant Chemotherapy for Locoregionally Advanced Non-small Cell Lung Cancer. In Neoadjuvant Chemotherapy. Jacquillat CL, Weil M, and Khayat D (eds.), Colleque INSERM/John Libbey Eurotext LTD. (publs.), 169: 377-381, 1988. 204. Vokes EE, Shilsky RL, Choi KE, Magid DM, Guarnieri CM, Whaling SM, Ratain J, Weichselbaum RR, and Panje WR: A Randomized Study Comparing Two Regimens of Induction Chemotherapy for Locally Advanced Head and Neck Cancer. In Neo-Adjuvant Chemotherapy. Jacquillat CL, Weil M, and Khayat S, (eds.), Colleque INSERM/John Libbey Eurotext LTD. (publs.) 169: 309-313, 1988. 32 205. Haraf DJ, and Weichselbaum RR: Treatment Selection in T1 and T2 Vocal Cord Carcinoma. Oncology 2 (10):41-50, 1988. 206. Vokes EE, Panje WR, Weichselbaum RR, Schilsky RL, Sutton HG, Moran WJ, and Guarnieri CM: Reirradiation with Concomitant 5-FU and Hydroxyurea. Effective Palliation for Recurrent Head and Neck Cancer. In Head and Neck Oncology Research. Wolf GT, and Carey TE (eds.), Kugler & Ghedini (publs.), pps.425-429, 1988. 207. Weichselbaum RR, Beckett M, Panje WR, Goldman M, Tybor AG, Moran WJ, Vokes EE, Ahmed-Swan S, Chen P, Ervin TJ, and Clark J: Radioresistant Human Squamous Carcinoma Cells May Account for Radiotherapy Failure in Head and Neck Cancer. In Head and Neck Oncology Research. Wolf GT, and Carey TE (eds.), Kugler & Ghedini (publs.), pps. 463-466, 1988. 208. Rotmensch J, Turkula T, Weichselbaum RR, and Schwartz JL: Cytogenetic Observations of a Human Ovarian Carcinoma Clinically Resistant to Therapy. Amer. J. OB/GYN. 159: 1099-1103, 1988. 209. Beckett M, and Weichselbaum RR: Southern Analysis of Human Head and Neck Cancer Cells for Homologous Sequences Using Yeast Gamma Repair Genes. J. Surg. Oncol. 38: 257-260, 1988. 210. Strauss B, Sagher D, Karrison T, Larson R, Meier P, Schwartz J, Farber T, and Weichselbaum RR: The Response of Human Cells to Methylation Damage. In Repair. Castellani A (ed.), Plenum Press (publs.), NY, pps.107-123, 1989. 211. Rotmensch J, Atcher RW, Schlenker R, Hines J, Grdina D, Block B, Press MF, Herbst AL, and Weichselbaum RR: The Effect of Alpha-emitting Radionuclide Lead 212 on Human Ovarian Carcinoma: A Potential New Form of Therapy. Gyne.Oncol. 32: 236-239, 1989. 212. Rotmensch J, Weichselbaum RR, and Atcher RW: Novel Treatment in Ovarian Cancer. Masters in Obstetrics and Gynecology. pps. 18-20, 1989. 213. Buick R, and Weichselbaum RR: Comments on Part II: Tumor Cell Response In Vitro. In Prediction of Tumor Treatment Response. Peters LJ, Chapman D, Withers HR (eds.) Pergamon Press (publs.), NY. pps. 187-194, 1989. 214. Weichselbaum RR, Rotmensch J, Ahmed-Swan S, and Beckett MA: Radiobiological Characterization of 53 Tumor Cell Lines. Reprinted In The Radiobiology of Human Cell and Tissues. Proceedings of the 15th LH Gray Conf. Canterbury England. Eds. Steel GG (eds.), Taylor Press (publs.), 1989. 215. Weichselbaum RR, Beckett MA, Diamond A: An Important Step in Radiation Carcinogenesis may be Inactivation of Cellular Genes. Int. J. Radiat. Oncol. Biol. Phys. 16: 277-282, 1989. 33 216. Vokes EE, Bitran JD, Hoffman PC, Ferguson M, Weichselbaum RR, and Golomb HM: Neoadjuvant Vindesine, Etoposiode, and Cisplatin for Locally Advanced Nonsmall Cell Lung Cancer: Final Report of a Phase II Study. Chest 96: 110-113, 1989. 217. Weichselbaum RR, Beckett MA, Ahmed-Swan S, Schwartz J: In Vitro Radiobiological Parameters of Freshly Cultured Human Tumor Cells Derived from Patients with Known Clinical Outcome. "Prediction of Response in Radiation Therapy". In The Physical and Biological Basis. Part I. Amer. Inst. of Phys. (publs.) NY, NY, 169-176, 1989. 218. Awan AM, Vokes EE, and Weichselbaum RR: Advances in Radiation Oncology in the Treatment of Head and Neck Tumors. In Advances in Otolaryngology, Head Surgery. Vol. III. Myers, Bluestone, Brachmann, Krause, (eds.); Year Book Medical Publs. 3: 257-287, 1989. 219. Pelizzari CA, Chen GTY, Spelbring DR, Weichselbaum RR, and Chen CT: Accurate Three-dimensional Registration of CT, PET, and/or MR images of the Brain. J. Comp. Assist. Tomogr. 13: 20-26, 1989. 220. Malaise EP, Fertil B, Chavaudra N, Brock WA, Rofstad EK, and Weichselbaum RR: The influence of Technical Factors on the In Vitro Measurement of Intrinsic Radiosensitivity of Cells Derived from Human Tumors. Prediction of Response in Radiation Therapy: In: The Physical and Biological Basis, Part. I. Amer. Inst. of Phys. (publs.), NY, NY, pps. 61-78, 1989. 221. Schwartz JL, Karrison T, LeBeau MM, Larson RA, Sagher D, Strauss B, Rowley J, and Weichselbaum RR: Chromosomal Sensitivity of Lymphocytes from Individuals with Therapy-related Acute Nonlymphocytic Leukemia. Mutat. Res. 216: 119-126, 1989. 222. Panje WR, Dohrmann GJ, Pitcock JK, Scher, N, Weichselbaum RR, Sutton HG, Vokes E, and Moss J.: The Transfacial Approach for Combined Anterior Craniofacial Tumor Ablation. Arch. Otolarngol. Head & Neck Surg.155: 301-307, 1989. 223. Farah R and Weichselbaum RR: Management of Stage I and II Hodgkin's Disease. In Hematology/Oncology Clinics of North America on Hodgkin's Disease. Golomb H, Williams S, and Farah R. (eds.), W.B. Saunders Co (publs.)., Philadelphia, PA., and Harcourt Brace Jovanovich Publishers, 3: 253-263, 1989. 224. Farah R, and Weichselbaum RR: The Substaging of Stage III Disease. In Hematology/Oncology Clinics of North America on Hodgkin's Disease. Golomb H, Williams S, and Farah R. (eds.), W.B. Saunders Co. Philadelphia, PA., and Harcourt Brace Jovanovich Publishers, 3: 277-286, 1989. 34 225. Weichselbaum RR, Dunphy EJ, Beckett MA, Tybor AG, Moran WJ, Goldman ME, Vokes EE, and Panje WR: Epidermal Growth Factor Receptor Gene Amplification and Expression in Head and Neck Cancer Cell Lines. Head & Neck 11: 437-442, 1989. 226. Vokes EE, Panje WR, Schilsky RL, Mick R, Awan AM, Moran WJ, Goldman MD, Tybor G, and Weichselbaum RR: Hydroxyurea, Fluorouracil and Concomitant Radiotherapy in Poor-Prognosis Head and Neck Cancer: A Phase I-II Study. J. Clin. Oncol. 7: 761-768, 1989. 227. Kasid U, Pfeifer A, Brennan T, Beckett MA, Weichselbaum RR, Dritschilo A, and Mark GE: Effect of Antisense c-raf-1 on Tumorigenicity and Radiation Sensitivity of a Human Squamous Carcinoma. Science 243: 1354-1356, 1989. 228. Vokes EE, Schilsky RL, Weichselbaum RR, Guaspari A, Guarnieri CM, Whaling SM, and Panje WR: Cisplatin, 5-Fluorouracil, and High-dose Oral Leucovorin for Advanced Head and Neck Cancer. Cancer 63: 1048-1053, 1989. 229. Vokes EE, Moran WJ, Mick R, Weichselbaum RR, and Panje WR: Neoadjuvant and Adjuvant Methotrexate, Cisplatin and Fluorouracil in Multimodal Therapy of Head and Neck Cancer. J. Clin. Oncol. 7: 838-845, 1989. 230. Hallahan DE, Farah R, Vokes EE, Bitran JD, Ultmann JE, Golomb HM, and Weichselbaum RR: The Patterns of Failure in Patients with Pathological Stage I and II Diffuse Histiocytic Lymphoma Treated with Radiation Therapy Alone. Int. J. Radiat. Oncol. Biol. Phys. 17: 767-771, 1989. 231. Hallahan DE, Michel AG, Awan AM, Halpern HJ, Desser R, Bitran J, Recant W, Wyman B, Spelbring DR, and Weichselbaum RR: Breast Conserving Surgery and Definitive Irradiation for Early Stage Breast Cancer. Int. J. Radiat. Oncol. Biol. Phys. 17: 1211-1216, 1989. 232. Kasid U., Weichselbaum RR, Brennan T, Mark G, and Dritschilo A: Sensitivities of NIH/3T3 Derived Clonal Cell Lines are Heterogeneous in their Ionizing Radiation: Significance for Gene Transfer Studies. Cancer Res.49: 3396-3400, 1989. 233. Rotmensch J, Beckett M, Toohill P, Weichselbaum RR, and Schwartz JL: Comparative Analysis of the Inherent Radiosensitivity of Ovarian Carcinoma. Gynecol. Obstet. Invest. 28: 215-218, 1989. 234. Farah R, Golomb H, Hallahan D, Desser R, Green M, Blough R, Ultmann J, and Weichselbaum RR: Radiation Therapy for Pathologic State III Hodgkins Disease with and without Chemotherapy. Int. J. Radiat. Oncol. Biol. Phys. 17: 761-766, 1989. 35 235. Vokes EE, Schilsky RL, Choi KE, Magid DM, Guarnieri CM, Whaling SM, Ratain MJ, Weichselbaum RR, and Panje WR: A Randomized Study of Inpatient versus Outpatient Continuous Infusion Chemotherapy for Patients with Locally Advanced Head and Neck Cancer. Cancer 63: 30-36, 1989. 236. Rotmensch J, Schwartz JL, Atcher RW, Grdina DJ, Toohill M, and Weichselbaum, RR: The Inherent Cellular Radiosensitivity of Epithelial Ovarian Carcinoma. Gynecol. Oncol. 35: 282-285, 1989. 237. Weichselbaum RR, Rotmensch J, Ahmed-Swan S, and Beckett MA: Radiobiological Characterization of 53 Tumor Cell Lines. Int. J. Radiat. Biol. 56: 553-560, 1989. 238. Weichselbaum RR, Beckett MA, Vijayakumar S, Ahmed-Swan S, Dritschilo A, Schwartz JL, Moran WJ, Goldman ME, Tybor AG, Vokes EE, and Panje WR: Radioresistant Tumor Cell Lines Derived from Head and Neck Radiation Failures. Head and Neck Surg. 11: 343-348, 1989. 239. Rotmensch J, and Weichselbaum RR: Characterization of Human Ovarian Carcinoma. Analytical and Quantitive Cytology and Histology. 11: 324-330, 1989. 240. Magid DM, Vokes EE, Schilsky RL, Guarnieri CM, Whaling SM, Weichselbaum RR, Panje WR: A Randomized Study of Inpatient versus Outpatient Continuous Intravenous Infusion Chemotherapy: Psychosocial Aspects. Selective Cancer Therapeutics 5: 137-145, 1989. 241. Hallahan DE, Spriggs DR, Beckett M, Kufe DW, and Weichselbaum RR: Increased Tumor Necrosis Factor á mRNA after Cellular Exposure to Ionizing Radiation. Proc. Nat. Acad. Sci. 86: 10104-10107, 1989. PMCID: PMC298653. 242. Pfeifer AMA, Kasid U, Tsokus MG, Kessler DK, Weichselbaum RR, Thorgeirsson SS, Dritschilo A, and Mark GE: Implication of the c-raf-1 Proto-oncogene in Neoplastic Transformation In Vivo and In Vitro. Cancer Cells 7: 177-181, 1989. 243. Panje WR, Dobleman TJ, Dohrmann G, Foust R, Vokes E, Mojtahedi S, Sutton H, and Weichselbaum, R.R.: Transpalatal and Transoral Approach to Tumors of the Clivus. In Neurological Surgery of the Ear and the Skull Base. Fisch U, Valavanis A, and Yasargil MG (eds.); Kugler & Ghedini (publs.). Amsterdam, Berkeley, Milano. pps.117-127, 1990. 244. Rotmensch J, Rubin SJ, Sutton HG, Ghodratollah J, Halpern HJ, Schwartz JL, Stewart M, Weichselbaum RR, and Herbst AL: Preoperative Radiotherapy followed by Radical Vulvectomy with Inguinal Lymphadenectomy for Advanced Vulvar Carcinomas. Gynecol. Oncol. 36: 181-184, 1990. 245. Hallahan DE, and Weichselbaum RR: Intrathoracic Malignancies: Non-Hodgkin's Lymphomas. In Internal Medicine for the Specialist. II:110-120, 1990. 36 246. Cowan JM, Beckett MA, Tarbell NJ, and Weichselbaum RR: Monosomy 12pin a Radiation Induced Germ Cell Tumor. Genes Chromosomes and Cancer 2: 186-190, 1990. 247. Springate SC, and Weichselbaum RR: Radiation or Surgery for Chemodectoma of the Temporal Bone: A Review of Local Control and Complications. Head & Neck Surgery, 303-307, 1990. 248. Schwartz JL, Mustafe R, Beckett MA, and Weichselbaum RR: Prediction of the Radiation Sensitivity of Human Squamous Cell Carcinoma Cells Using DNA Filter Elution. Radiation Research 123: 1-6, 1990. 249. Weichselbaum RR, Beckett MA, Vijayakumar S, Simon MA, Awan AM, Nachman J, Panje WR, Goldman ME, Tybor AG, Moran WJ, Vokes EE, Ahmed-Swan S, and Farhangi E: Radiobiological Characterization of Head and Neck and Sarcoma Cells derived from Patients prior to Radiotherapy. Int. J. Radiat. Biol. Phys.19: 313-319, 1990. 250. Vokes EE, Schilsky RL, Weichselbaum RR, Kozloff MF, and Panje WR: Induction Chemotherapy with Cisplatin, Fluorouracil, and High-Dose Leucovorin for Locally Advanced Head and Neck Cancer: A Clinical and Pharmacologic Analysis. J. Clin. Oncol. 8: 241-247, 1990. 251. Vokes EE and Weichselbaum RR: Concomitant Chemoradiotherapy: Rationale and Clinical Experience in Patients with Solid Tumors. J. Clin. Oncol. 5: 911-934,1990. 252. Hallahan DE, Beckett MA, Kufe D, and Weichselbaum RR: The Interaction between Recombinant Human Tumor Necrosis Factor and Radiation in 13 Human Tumor Cell Lines. Int. J. Radiat. Biol. Phys. 19: 69-74, 1990. 253. Kolker JD, Halpern HJ, Krishnasamy S, Brown F, Dohrmann G, Ferguson L, Hekmatpanah J, Mullan J, Wollman R, Blough R, and Weichselbaum RR: "InstantMix" Whole Brain Photon with Neutron Boost Radiotherapy for Malignant Gliomas. Int. J. Radiat. Oncol. Biol. Phys. 19: 409-414, 1990. 254. Rotmensch J, Roeske J, Chen G, Pelizzari C, Montag A, Weichselbaum RR, and Herbst AL: Estimates of Dose to Intraperitoneal Micrometastases from Alpha and Beta Emitters in Radioimmunotherapy. Gyne. Oncol. 38: 478-485, 1990. 255. Vokes EE, Panje WR, Mick R, Kozloff MF, Moran WJ, Sutton HG, Goldman MD, Tybor AG, and Weichselbaum RR: A Randomized Study Comparing Two Regimens of Neoadjuvant and Adjuvant Chemotherapy in Multimodal Therapy for Locally Advanced Head and Neck Cancer. Cancer 66: 206-213, 1990. 37 256. Cowan JM, Beckett MA, Tarbell N, and Weichselbaum RR: Symmetrical Chromsome Rearrangements in Cell Lines Established from Human Radiation Induced Sarcomas. Cancer Genetics and Cytogenetics 50: 125-137, 1990. 257. Sherman ML, Datta R, Hallahan DE, Weichselbaum RR, and Kufe DW: Ionizing Radiation Regulates Expression of the c-jun Proto-Oncogene. Proc.Nat. Acad. Sci. 87: 5663-5666, 1990. 258. Jaffe DR, Haraf D, Schwartz JL, Weichselbaum RR, and Diamond AM: Radioresistant Derivatives of an X-Ray Sensitive CHO Cell Line Exhibit Distinct Patterns of Sensitivity to DNA-Damaging Agents. Carcinogenesis 11: 1265-1269, 1990. 259. Roeske JC, Chen GTY, Atcher RW, Pelizzari CA, Rotmensch J, Haraf D, Montag A, and Weichselbaum RR: Modeling of Dose to Tumor and Normal Tissue from Intraperitoneal Radioimmunotherapy with Alpha and Beta Emitters. Int. J. Radiat. Oncol., Biol. Phys. 19: 1539-1548, 1990. 260. Young RC, Longo DL, Ozols RF, Simone JV, Steele G, .Jr, and Weichselbaum RR (eds.), The Year Book of Oncology 1990, Mosby Year Book, Inc. (publs.), St.Louis, MO, 1990. 261. Awan A, and Weichselbaum RR: Palliative Radiotherapy; Non-Small Cell Lung Cancer. In Hematol .Clin. North Am. 4:1169-1181, Bitran J, et al., (eds.), 1990. 262. Panje WR, Shaw GY, Foust R, Dohrmann G, III, Vokes EE, Jojtahedi S, Sutton H, Weichselbaum RR: Management of Petrous Apex Neoplasms including Nasopharynx, Temporal Bone, and Parotid Gland. In Neurological Surgery of the Ear and Skull Base. Fisch U, Valavanis A, Yasabil MG, (eds.), Kugler & Ghedini (publs.), Amsterdam, Berkeley, Milano. pps.39-45, 1990. 263. Panje WR, Pitcock JK, Dohrmann GH, Mojtahedi S, Foust R, Scher N, Weichselbaum RR, Sutton H, Vokes EE, Knapp B, Guarinieri C: The Transfacialintracranial "Swinging" Nasofrontal Bone Flap Approach to the Anterior Cranial Skull Base. In Neurological Surgery of the Ear and Skull Base. Fisch U, Valavanis A, Yasabil MG (eds.), Kugler & Ghedini (publs.), Amsterdam, Berkeley, Milano. pps.327-337, 1990. 264. Rader JS, Haraf DJ, Halpern HJ, Rotmensch J, Spelbring DR, Sutton HG, Javaheri G, and Weichselbaum RR: Radiation Therapy in the Treatment of Cervical Cancer: The University of Chicago/Michael Reese Hospital Experience. J. Surg. Oncol. 44: 157-165, 1990. 265. Hallahan D E, and Weichselbaum RR: Intrathoracic Malignancies: Hodgkin's Disease. In Internal Medicine for the Specialist. Vol.12: 56-64,1991. 38 266. Springate SC, Haraf D, and Weichselbaum RR: Temporal Bone Chemodectomas comparing Surgery and Radiation Therapy. Oncology 5: 131-137, 1991. 267. Farah R, Chodak GW, Vogelzang NJ, Awan AM, Quiet CA, Moormeier J, Schoenberg H, and Weichselbaum RR: Curative Radiotherapy Following Chemotherapy for Invasive Bladder Carcinoma. Int. J.Radiat. Oncol. Biol. Phys. 20: 413-417, 1991. 268. Farah R, and Weichselbaum RR: Principles of Radiation Biology and Radiation Therapy. In Neoplastic Diseases of Childhood Diseases. Eds. Pochedly C (eds.), Harwood (publ.), (In Press). 269. Morrow M, Hoffman PC, and Weichselbaum RR: Locally Advanced Breast Cancer. In Breast Diseases, 2nd Edition. Harris JR, Hellman S, Henderson IC, and Kinne DW (eds.), J.B. Lippincott Co. (publs.), Philadelphia, PA, pps.767-774,1991. 270. Weichselbaum RR: Cellular and Molecular Aspects of Human Tumor Radioresistance. In Important Advances in Oncology, 1991. Hellman S, DeVitaV, Rosenberg S (eds.), J.B. Lippincott Co. (publs.), Philadelphia, PA., 73-83,1991. 271. Harstell W, Farah R, Murthy A, Golomb H, and Weichselbaum RR: Is Pelvic Irradiation Necessary in Stage III1A Hodgkins Disease. Int. J. Radiat. Oncol. Biol.Phys. 19: 715-719, 1991. 272. Rubin SJ, Hallahan DE, Ashman CR, Brachman DG, Beckett MA, Virudachalam S, Yandell DW, and Weichselbaum RR: Two Prostate Carcinoma Cell Lines Demonstrate Abnormalities in Tumor Suppressor Genes. J. Surg. Oncol. 46: 31-36, 1991. 273. Haraf D, Vokes E, Panje W, and Weichselbaum RR: Survival and Analysis of Failure following Hydroxyurea 5-fluorouracil and Concomitant Radiation Therapy in Poor Prognosis Head and Neck Cancer. Am. J. Clin. Oncol. 14: 419-426, 1991. 274. Samuels B, Murray JL, Cohen MB, Safa AR, Sinha B, Townsend AJ, Beckett MA, and Weichselbaum RR: Increased Gluthathione Peroxidase Activity in a Human Sarcoma Cell Line with Inherent Doxorubicin Reisitance. Cancer Res. 51: 521-527, 1991. 275. Singer PA, Tasch ES, Stocking C, Rubin S, Siegler M. and Weichselbaum RR: Sex or Survival? Tradeoffs Between Quality and Quantity of Life. J. Clin.Oncol. 9: 328334, 1991. 276. Quiet C, and Weichselbaum RR, and Grdina D.: Variation in Radiation Sensitivity During the Cell Cyle of Two Human Squamous Cell Carcinomas. Int. J. Radiat. Oncol. Biol. Phys. 20: 733-738,1991. 39 277. Awan A, Vokes EE, and Weichselbaum RR: Recent Advances in Radiation Therapy for Head and Neck Cancer. In Hematology/Oncology Clinics of North America. Vokes EE (ed.), W.B. Saunders, Harcourt Brace Jovanovich, Inc. (publs.), Philadelphia, PA, pps. 635-655, 1991. 278. Vokes EE, Awan AM, and Weichselbaum RR: Radiotherapy with Concomitant Chemotherapy for Head and Neck Cancer. In Hematology/Oncology Clinics of North America. Vokes EE (ed.), W.B. Saunders, Harcourt Brace Jovanovich, Inc. (publs.), Philadelphia, PA, pps. 753-767, 1991. 279. Hallahan DE, Sukhatme CP, Sherman ML, Virudachalam S, Kufe D, and Weichselbaum RR: Protein-Kinease-C Mediates X-ray Inducibility of Nuclear Signal Transducers EGR-1 and JUN. Proc. Nat. Acad. Sci.,88: 2156-2160, 1991. 280. Sherman ML, Datta R, Hallahan DE, Weichselbaum RR, and Kufe DW: Regulation of Tumor Necrosis Factor Gene Expression by Ionizing Radiation in Human Myeloid Leukemia Cells and Peripheral Blood Monocytes. J. Clin. Invest. 87: 1794-1797, 1991. PMCID: PMC295295. 281. Schwartz JL, Mustafi R, Beckett MA, Czyzewski A, Farhangi E, Grdina DJ, Rotmensch J, and Weichselbaum RR: Radiation-Induced DNA Double-Strand Break Frequencies in Human Squamous Cell Carcinoma Cell Lines of Different Radiation Sensitivities. Int. J. Radiat. Biol. 6: 1341-1352, 1991. 282. Brachman DG, and Weichselbaum RR: Radiation Therapy of Rectal Carcinoma. Postgraduate Gen. Surg. 3: 93-102, 1991. 283. Halpern HJ, Jaffe DR, Nguye T, Haraf DJ, Spencer DP, Bowman MK, and Weichselbaum RR, Diamond A: Measurement of Bioreduction Rates of Cells with Distinct Responses to Ionizing Radiation and Cisplatin. Biochim. Biophys. Acta, 1093: 121-124, 1991. 284. Vokes EE and Weichselbaum RR: Experimental Basis for Radiation and Chemotherapy. In Combined Modality Cancer Therapy. Lokich J, and Byfield JE (eds.), Precept Press, Inc. (publ.) Chicago, IL, pps. 1-14, 1991. 285. Brach MA, Hass R, Sherman ML, Gunji H, Weichselbaum RR, and Kufe D: Ionizing Radiation Induces Expression and Binding Activity of the Nuclear Factor êB. J. Clin.Invest. 88: 691-695, 1991. 286. Weichselbaum RR, Hallahan DE, Sukhatme V, Dritschilo A, Sherman ML, and Kufe D: Biological Consequences of Gene Regulation following Ionizing Radiation. J. Nat. Cancer Inst. 83: 480-484, 1991. 287. Gradishar W, E, Schilsky R., Weichselbaum RR, and Panje W: Catastrophic Events following 5-Fluorouracil Chemotherapy: The University of Chicago Experience. Med. and Ped. Oncol. 19: 8-15, 1991. 40 288. Weichselbaum RR: Possible Applications of Biotechnology to Radiotherapy. Europ. J. Cancer 27: 405-407, 1991. 289. Haraf DJ, Drucker DR, Weichselbaum RR, and Diamond AM: Radioresistant Derivatives of Radiosensitive CHO Cells Obtained Following Treatment with 5azacytidine Retain their Sensitivity to Cisplatin. Rad. Res. 127: 226-229, 1991. 290. Mick R, Vokes EE, Weichselbaum RR, and Panje WR: Prognostic Factors in Advanced Head and Neck Cancer Patients Undergoing Multimodality Therapy. Otolaryngol-Head Neck Surg. 105: 62-73, 1991. 291. Vokes EE, Mick R, Lester EP, Panje WR, and Weichselbaum RR: Cisplatin and 5fluorouracil Does Not Yield Long-term Benefit in Locally Advanced Head and Neck Cancer: Results from a Single Institution. J. Clin.Oncol. 9: 1376-1384, 1991. 292. Kies MS, Pelzer H, Kolker JD, Weichselbaum RR, and Breit R: Multidisciplinary Case Review: Management of Squamous Cancer of the Tongue. Contemporary Oncology 1: 55-59, 1991. 293. Vokes E, and Weichselbaum RR: Modulation de L'Activite du 5-Flurouracile Par L'Acide Folinique, en Association Avec L'Hyroxyuree et la Radiotherapie Dans Le Traitment Des Cancers Des Voies Aerodigestives Superieures (VADS): Essais Cliniques a L'Universite de Chicago. In Resistance Metabolique Aux Fluropyrimidines: Donnees Actuelles et Perspectives. Machover D, and Rustum Y (eds.), pps. 109-113, 1991. 294. Hallahan DE, Sherman ML, Kufe D, and Weichselbaum RR: Ionizing RadiationMediated Protein-Kinase C Activation and Gene Expression. In Neoplastic Transformation in Human Cell Culture Mechanisms of Carcinogenesis. Rhim J, and Dritschilo A (eds.), Humana Press Inc. (publs.), Clifton, NJ, pps. 81-92, 1991. 295. Hallahan DE, Virudachalam D, Beckett MA, Sherman ML, Kufe DW, and Weichselbaum RR: Mechanisms of X-ray Mediated Protooncogene c-jun Expression in Radiation-Induced Human Sarcoma Cell Lines. Int. J. Radiat. Oncol. Biol. Phys. 21: 1677-1681, 1991. 296. Hallahan DE, Virudachalam S, Sherman ML, Huberman E, Kufe DW, and Weichselbaum RR: Tumor Necrosis Factor Gene Expression is Mediated by Protein Kinase C following Activation by Ionizing Radiation. Can. Res. 51: 4565-4569, 1991. 297. Vijayakumar S, Low N, Chen GTY, Myrianthopoulos L, Culbert H, Chiru P, Spelbring D, Awan A, Rosenberg I, Halpern H, and Weichselbaum RR: Beams Eye View-Based Photon Radiotherapy I.Int. J. Radiat. Oncol. Biol. Phys. 21: 1575-1586, 1991. 41 298. Devine S, Vokes E, and Weichselbaum RR: Chemotherapeutic and Biologic Radiation Enhancement. Current Opinion In Oncology 3: 1087-1095, 1991. 299. Young RC, Longo DL, Ozols RF, Simone JV, Steele G, Jr., and Weichselbaum RR, (eds.), The Year Book of Oncology, Mosby Year Book, Inc., (publs.) St. Louis, MO, 1991. 300. Brachman D, Hallahan D, Beckett MA, Yandell D, and Weichselbaum RR: p53 Gene Mutations and Abnormal Retinoblastoma Protein in Radiation-induced Human Sarcomas. Can. Res. 51: 6393-6396, 1991. 301. Haraf DJ, Vokes EE, Panje WR, and Weichselbaum RR: Efficacy of Concomitant Chemoradiotherapy in Poor Prognosis Head and Neck Cancer. In Proceedings.3rd International Conference on Neo-Adjuvant Chemotherapy. Banzet P, Holland JF, Khayat D, and Weil M (eds.) Springer-Verlag (publs.), Paris, France, pps. 61-65, 1991. 302. Vokes EE, Panje WR, and Weichselbaum RR: 5-Fluorouracil Modulation in Head and Neck Cancer. In Proceedings.3rd International Conference on Neo-Adjuvant Chemotherapy. Banzet P, Holland JF, Khayat D, and Weil M (eds.) Springer-Verlag (publs.), Paris, France, pps. 54-57, 1991. 303. Vokes EE, Haraf DJ, Panje WR, McEvilly JM, Kozloff MF, Goldman D, Clendeninn N, Tybor AG, Collier M, and Weichselbaum RR: Cisplatin, 5Fluorouracil and High Dose Oral Leucovorin (PFL) with Methotrexate and Pivitrexin as Neo-Adjuvant Chemotherapy for Head and Neck Cancer. In Proceedings.3rd International Conference on Neo-Adjuvant Chemotherapy. Banzet P, Holland JF, Khayat D, and Weil M (eds.) Springer-Verlag (publs.), Paris, France, pps.58-60, 1991. 304. Brachman D, and Weichselbaum RR: ICU Complications of Radiation Therapy. In Principles of Critical Care Medicine. Hall, Schmidt, and Wood (eds.), McGraw-Hill, NY (publs.), pps. 1890-1898, 1992. 305. Vokes EE, Weichselbaum RR, Mick R, McEvilly JM, Haraf DJ, and Panje WR: Favorable Long-Term Survival Following Induction Chemotherapy with Cisplatin, Fluorouracil and Leucovorin and Concomitant Chemoradiotherapy for Locally Advanced Head and Neck Cancer. J. Natl. Canc. 84: 877-882, 1992. 306. Schwartz J, Beckett MA, Mustafi, R., Vaughan ATM, and Weichselbaum RR: Evaluation of Different In Vitro Assays of Inherent Sensitivity as Predictors of Radiotherapy Response. In Radiation Research: A Twentieth-Century Perspective. Volume II: Congress Proceedings. Dewey et al. (eds.), Academic Press, Inc. (publs.), San Diego, CA, pps.716-721, 1992. 42 307. Weichselbaum RR, Beckett MA, and Schwartz J: Where do Radioresistant Cells Come From? In Radiation Research: A Twentieth-Century Perspective. Volume II: Congress Proceedings. Dewey, Edington, Fry, Hall and Whitmore (eds.), Academic Press, Inc. (publs.), San Diego, CA, pps.751-755, 1992. 308. Hallahan DE, Virudachalam S, Schwartz JL, Panje N, Mustafi R, and Weichselbaum RR: Inhibition of Protein Kinase Sensitizes Human Tumor Cells to Ionizing Radiation. Rad.. Res. 129: 345-350, 1992. 309. Rubin E, Kharbanda S, Gunji H, Weichselbaum RR, and Kufe D:Cis-Diamminedichlorplatinum (II) Induces c-jun Expression in Human Myeloid Leukemia Cells: Potential Involvement of a Protein Kinase C-Dependent Signaling Pathway. Can. Res. 878-882, 1992. 310. Wong WW, Vijayakumar S, and Weichselbaum RR: Prognostic Indicators in NodeNegative Early Stage Breast Cancer. Am. J. Med. 92: 539-548, 1992. 311. Brachman DG, Graves D, Vokes E, Beckett M, Haraf D, Montag A, Dunphy E, Mick R, andell D, and Weichselbaum RR: Occurrence of p53 Gene Deletions and Human Papilloma Virus Infection in Human Head and Neck Cancer. Can. Res.52: 4832-4836, 1992. 312. Weichselbaum RR: Epigenetic Effects on Radiosensitivity: The Extracellular Matrix and Growth Factors. Europ. J. Cancer 28A: 723-724, 1992. 313. Vokes EE, Haraf DJ, Panje WR, Schilsky RL, and Weichselbaum RR: Hydroxyurea with Concomitant Radiotherapy for Locally Advanced Head and Neck Cancer. Sem. In Oncol. 19: 53-58, 1992. 314. Toguchida J, Yamagachi T, Dayton S, Beaumchamp RL, Herrera E, Ishigahi K, Yamamuro T, KaturaY, Takada N, Kawaguchi N, KanekoY, Meyers P, Little JB, Ritchie B, Sasaki M, Weichselbaum RR, and Yandell DN: Prevalence and Spectrum of Germline Mutations of the p53 Gene Among Patients with Sarcoma. New Eng. J. Medicine 326: 1301-1308, 1992. 315. Latif F, Fivach M, Glenn G, Tory K, Orcutt ML, Hampsck K, Delisio J, Lerman M, Cowan J, Beckett M, and Weichselbaum RR: Chromosome 3p deletions in Head and Neck Carcinomas: Statistical Ascertainment of Allelic Loss. Can. Res. 52: 14511456, 1992. 316. Dunphy EJ, Beckett MA, Thompson LH, and Weichselbaum RR: Expression of the Polymorphic Human DNA Repair Gene XRCCI Does Not Correlate with Radiosensitivity in Human Head and Neck Tumor Cell Lines. Rad. Res. 130: 166170, 1992. 43 317. Platanias LC, Putterman AM, Vijayakumar S, Recant W, Weichselbaum RR, and Bitran JD: Treatment and Prognosis of Orbital Non-Hodgkin's Lymphomas. Am. J. Clin. Onc. 15: 79-83, 1992. 318. Jaffe DR, Montero-Puerno Y, Beckett MA, Cowan JM, Weichselbaum RR, and Diamond AM: Differential Retention of Tumor and Differentiation-Suppressor Functions in Cells Derived from a Human Squamous Cell Carcinoma. Molecular Carcinogenesis 5: 278-285, 1992. 319. Cowan JM, Beckett MA, Ahmed-Swan S, and Weichselbaum RR: Cytogenetic Evidence of the Multistep Origin of Head and Neck Squamous Cell Carcinomas. JNCI 84: 793-797, 1992. 320. Weichselbaum RR, Beckett MA, Hallahan DE, Kufe DW, and Vokes EE: Molecular Targets to Overcome Radioresistance. Sem. In Oncol.14: 14-20, 1992. 321. Hass R, Gunji H, Datta R, Kharbanda S, Hartmann A, and Weichselbaum RR: differentiation and Retrodifferentiation of Human Myeloid Luekemia Cells Is Associated with Reversible Induction of Cell Cycle-regulatory Genes. Cancer Res. 52: 1445-1450, 1992. 322. Grdina DJ, Dale P, and Weichselbaum RR: Protection Against AZT-Induced Mutagenesis at the HGPRT Locus in a Human Cell Line by WR-151326. Int. J. Radiat. Oncol. Biol. Phys. 22: 813-815, 1992 323. Vokes EE, Moormeier JA, Ratain MJ, Egorin MJ, Haraf DJ, Mick R, and Weichselbaum RR: 5-Fluorouracil, Leucovorin, Hydroxyurea, and Escalating Doses of Continuous-Infusion Cisplatin with Concomitant Radiotherapy: A Clinical and Pharmacologic Study. Cancer Chemother.Pharmacol. 29: 178-184, 1992. 324. Hallahan DE, Virudachalam S, Grdina D, and Weichselbaum RR: The Isoquinoline Sulfonamide H7 Attenuates Radiation-Mediated Protein Kinase C Activation and Delays the Onset of Xray Induced G2 Arrest. Int. J. Radiat. Oncol. Biol. Phys. 24:687692, 1992. 325. Vijayakumar S, Karrison, T, Weichselbaum RR, Chan S, Quadri SF, and Awan AM: Racial Differences in Prostate-specific Antigen Levels in Patients with LocalRegional Prostate Cancer. Cancer Epidermiology Biomarkers & Prevention: 1: 541545, 1992. 326. Weichselbaum RR, Hallahan DE, Sukhatme V, Kufe DW: Gene Therapy Targeting by Ionizing Radiation. Int. J. Radiat. Oncol. Biol. Phys. 24:565-567, 1992. 44 327. Datta R, Hass R, Gunji H, Weichselbaum RR, and Kufe D: Down Regulation of Cell Cycle Control Genes by Ionizing Radiation. Cell Growth and Differentiation 3:637-644, 1992. 328. Vijayakumar S, Czerski L, Majors A, Valenzuela R, Beckett M, Weichselbaum RR, and Ng T: Phosphorous Metabolite and Cell Cycle Kinetic Response of Two Human Squamous Cell Carcinomas to Radiat. Can. Res.52: 5299-5306, 1992. 329. Datta R, Hallahan D, Kharbanda S, Rubin E, Sherman M, Huberman E, Weichselbaum RR, and Kufe D: Involvement of Reactive Oxygen Intermediates in the Activation of c-jun Gene Transcription by Ionizing Radiation. Biochemistry 31: 8300-8306, 1992. 330. Fuks Z, and Weichselbaum RR: Radiation Tolerance and the New Biology: Growth Factor Involvement in Radiation Injury to the Lung. Int. J. Radiat. Oncol. Biol. Phys. 24:183-184, 1992. 331. Weichselbaum RR, Hallahan D, and Kufe D: Gene Induction by Ionizing Radiation. In Radiation Research: A Twentieth-Century Perspective. Volume II: Congress Proceedings. Dewey et al (eds.)., Academic Press, Inc. (publs.), San Diego, CA, pps.375-379, 1992. 332. Datta R, Rubin E, Sukhatme V, Quershi S, Hallahan D, Weichselbaum RR, and Kufe D: Ionizing Radiation Activates Transcription of the EGR-1 Gene via CArG Elements. Proc. Nat. Acad. Sci. 89: 10149-10153, 1992. 333. Vokes EE, Haraf DJ, Weichselbaum RR, McEvilly JT, Sutton HG, and Panje WR: Perspectives on Combination Chemotherapy with Concomitant Radiotherapy for Poor-Prognosis Head and Neck Cancer. Sem. in Oncol.19:47-56, 1992. 334. Haraf DJ, Vokes EE, Weichselbaum RR, Panje WR: Concomitant Chemoradiotherapy with Cisplatin, 5-Fluorouracil and Hydroxyurea in Post-Prognosis Head and Neck Cancer. Laryngoscope 102: 630-636, 1992. 335. Toguchida J, Yamaguchi T, Ritchie B, Beauchamp RL, Dayton SH, Herrera GE, Yamamuro T, Kotoura Y, Sasaki M, Little JB, Weichselbaum RR, Ishizaki K, and Yandell DW: Mutation Spectrum of the p53 Gene in Bone and Soft Tissue Sarcomas. Can. Res. 52: 6194-6199, 1992. 336. Vokes EE, Beckett M, Karrison T, and Weichselbaum RR: The Interaction of 5Fluorouracil, Hydroxyurea, and Radiation in Two Human Head and Neck Cancer Cell Lines. Oncology 49: 454-460, 1992. 45 337. Vokes EE, Haraf DJ, McEvilly JM, Mick R, Kozloff MF, Goldman MD, Moran WJ, Clendeninn NJ, Collier RR, Weichselbaum RR, Panje WR: Neoadjuvant , PFL Augmented by Methotrexate and Piritrexim followed by Concomitant Chemoradiotherapy for Advanced Head and Neck Cancer: A Feasible and Active Approach. Annals of Oncol. 3: 79-81, 1992. 338. Hallahan D, Gius D, Kuchibhotla J, SukhatmeV, Kufe DW, and Weichselbaum RR: Radiation Signaling Mediated by Jun Activation following Dissociation from a CellType specific Repressor. J. Biol. Chem. 368: 4903-4907, 1992. 339. Rosen A, Vokes EE, Scher N, Haraf D, Weichselbaum RR, and Panje WR: Locoregionally Advanced Paranasal Sinus Carcinoma - Favorable Survival with Multimodality Therapy. Arch.Otol.Head Neck Surg. 119: 743-746, 1993. 340. Weichselbaum RR, Hallahan DE, Chen GTY: Biological and Physical Basis to Radiation Oncology. In Cancer Medicine, 3rd Edition, Holland J, Frei E, Bast RC, Kufe D, Morton DL, and Weichselbaum RR (eds.), Lea and Febiger (publs.), Malvern, PA, pps. 539-566, 1993. 341. Holland J, Frei E, Bast RC, Kufe D, Morton DL, and Weichselbaum RR, In Cancer Medicine, 3rd Edition, Holland J, Frei E, Bast RC, Kufe D, Morton DL, and Weichselbaum RR (eds.), Lea and Febiger (publs.), Malvern, PA, 1993. 342. Hallahan DE, Haimovitz-Friedman A, Kufe D, Fuks Z, and Weichselbaum RR: The Role of Cytokines in Radiation Oncology. In Important Advances in Oncology 1992. DeVita, Hellman, and Rosenberg (eds.), J.B. Lippincott Co. (publs.), Philadelphia, PA, pps. 71-80, 1993. 343. Hallahan DE, Weichselbaum RR, and Kufe D: Signal Transduction and Gene Expression during Mamamlian Cell Response to Ionizing Radiation. In: Drug Resistance in Oncology, Teicher (publs.), Dekker, NY, pps. 603-614, 1993. 344. Weichselbaum RR, Beckett MA, Vokes EE, Hallahan DE, Haraf DJ, and Brachman DG: Cellular and Molecular Basis for Radioresistance in Head and Neck Cancer. In Proc. Int. Head & Neck Cancer, Vol.III. Johnson JT, Didolkar MS (eds.), Excerpta Medica (publs.), Amsterdam, The Netherlands, pps. 399-407, 1993. 345. Datta R, Weichselbaum RR, and Kufe DW: Ionizing Radiation Down-Regulates Histone H1 Gene Expression by Transcriptional and Postranscriptional Mechanisms. Rad. Res. 133: 176-181, 1993. 346. Vogelzang NJ, Moormeier JA, Awan AM, Weichselbaum RR, Farah R, Straus FH, Schoenberg HW, Chodak GW: MVAC Followed by Radiotherapy or Surgery for Muscle invadfing Bladder Cancer: the University fo Chicago Experience. J. Urol. 149: 753-757, 1993. 46 347. Vijayakumar S, Awan A, Karrison T, Culbert H, Chan S, Kolker J, Low N, Halpern H, Rubin S, Chen GTY, and Weichselbaum RR: Acute Toxicity During ExternalBeam Radiotherapy for Localized Prostate Cancer: Comparison of Different Techniques. Int. J. Radiat. Oncol. Biol. Phys. 25: 359-371, 1993. 348. Datta R, Taneja N, Sukhatme VP, Qureski SA, Weichselbaum RR, and Kufe DW: Reactive Oxygen Intermediates Target CArG Sequences to Mediate Activation of the Immediate Early Transcription Factor EGR-1 by Ionizing Radiation. Proc. Nat. Acad. Sci. 90: 2419-2423, 1993. 349. Fuks Z and Weichselbaum RR: Radiation Therapy, In Molecular Basis of Cancer Therapy Section IV, pps. 401-431, 1993. 350. Vokes EE, Weichselbaum RR, Lippman SM, and Hong WK: Review Article, Medical Progress: Head and Neck Cancer. New Eng. J. Med. 328:184-194, 1993. 351. Vokes EE, Ratain MJ, Mick R, McEvilly JM, Haraf D, Kozloff M, Hamasaki V, Weichselbaum RR, Panje WR, Wenig B, and Berezin F: Cisplatin, Fluorouracil, and Leucovorin Augmented by Interferon Alfa-2b in Head and Neck Cancer: A Clinical and Pharmacologic Analysis. J. Clin. Onc. 11: 360-368, 1993. 352. Pekarek LA, Weichselbaum RR, Beckett MA, Nachman J, Schreiber H: Footprinting of Individual Tumors and Their Variants by Constitutive Cytokine Expression Patterns. Can. Res. 53: 78-1981, 1993. 353. Hass R, Gunji H, Hirano M, Weichselbaum RR, and Kufe D: Phorbol Ester-induced Monocytic Differentiaiton is Associated with G2 Delay and Down-regulation of cdc25 Expression. Cell & Growth Diff. 4: 159-166, 1993. 354. Czerski L, Majors A, Ng T, Vijayakumar S, Weichselbaum RR: Growth and Magnetic Resonance Characteristics of Human Squamous Cell Carcinoma Xenografts Implanted with Cells Suspended in Matrigel.TM NMR in Biomedicine 6: 297-301, 1993. 355. Holland JF, Frei III, E, Bast-Jr RC, Kufe DW, Morton DL, and Weichselbaum RR: Principles of Multi-disciplinary Management. In Cancer Medicine, 3rd Edition. Holland, Frei, Bast, Kufe, Morton, Weichselbaum (eds.), Lea & Febiger (publs.), pps. 1073-1079, 1993. 356. Vijayakumar S, Roach M, Wara W, Chan SK, Ewing C, Rubin S, Sutton H, Halpern H, Awan A, Houghton A, Quiet C, Weichselbaum RR: Effect of Subcutaneous Recombinant Human Erythropoietin in Cancer Patients Receiving Radiotherapy: Preliminary Results of a Randomized, Open-Labeled, Phase II Trial. Int. J. Radiat. Oncol. Biol. Phys. 26(4):721-729, 1993. 47 357. Weichselbaum RR, Fuks Z, Hallahan DE, Haimovitz-Friedman A, Kufe DW: Radiation-induced Cytokines and Growth Factors; Cellular and Molecular Basis of the Modification of Radiation Damage. In Molecular Biology for Clinical Oncologists. Yarnold (eds.), Elsevier Sci. (publs.), Amsterdam, The Netherlands, 213-231, 1993. 358. Vokes EE, Haraf DJ, Weichselbaum RR, Brachman D.: Induction Chemotherapy: Promises and Limitations. In Proc. Int. Head and Neck Cancer. Vol. III. Johnson JT, and Didolkar MS (eds.), Excerta Medical (publs.), Amsterdam, The Netherlands, pps. 321-326, 1993. 359. Brachman D, Beckett M, Graves D, Haraf D, Vokes E, and Weichselbaum RR: P53 Mutation Does Not Correlate with Radiosensitivity in 24 Head and Neck Cancer Cell Lines. Can. Res. 53: 3667-3669, 1993. 360. Vokes EE, and Weichselbaum RR: Chemoradiotherapy for Head and Neck Cancer. In Principles and Practices of Oncology - PPO Updates 7: 1-12, 1993. 361. Manome Y, Datta R, Taneja N, Shafman T, Bump E, Hass R, Weichselbaum RR, and Kufe D: Coinduction of c-jun Gene Expression and Internucleosomal DNA Fragmentation by Ionizing Radiation. Biochemistry 32: 10607-10613, 1993. 362. Vokes EE, Dolan ME, Krishnasamy S, Mick R, Ratain MJ, Berezin F, Brachman D, Whitman G, Schilsky RL, Charette J, Weichselbaum RR, Dohrmann GJ, Hekmatpanah J: 5-Fluorouracil, Hydroxyurea and Escalating Doses of Iododeoxyuridine with Concomitant Radiotherapy for Malignant Gliomas: A Clinical and Pharmacologic Analysis. Annals of Oncol. 4: 591-595, 1993. 363. Fuks Z, Haimovitz-Friedman A, Hallahan DE, Kufe DW, and Weichselbaum RR: Stress Response Genes Induced in Mammalian Cells by Ionizing Radiation. Radiat. Oncol. Invest. 1: 81-93, 1993. 364. Manome, Y., Weichselbaum, R.R., Kufe, D.W., Fine, H.A.: Effect of on Ionizing and 1-beta-D-Arabinofuranosylcytosinic-Induced Internucleosomal DNA Fragmentation and Cell Survival in Human Myeloid Leukemia Cells. Oncol. Res. 5: 139-144, 1993. 365. Brachman DG, and Weichselbaum RR: Editorial Comments: Conformal High-Dose Radiation Plus Intraarterial Floxuridine for Hepatic Cancer. Oncology 7: 57-58, 1993. 366. Cowan JM, Beckett MA, and Weichselbaum RR: Chromosome Changes Characterizing in Vitro Response to Radiation in Human Squamous Cell Carcinoma Lines. Cancer Res. 53: 5542-5547, 1993. 367. Vokes EE, Weichselbaum RR: Measurable Impact: Multimodality Therapy of Head and Neck Cancer. Int. J. Radiat. Oncol. Biol. Phys. 27: 481-482, 1993. 48 368. Hallahan D, Sherman ML, Kufe DW, and Weichselbaum RR: Radiation-Induced Gene Expression. In Radiation Oncology, Technology and Biology. Chapter 20, Mauch and Leoffler (eds.), W.B. Saunders Co. (publs.), pps. 458-469, 1994. 369. Brachman D, Haraf D, and Weichselbaum RR: Radiotherapy of Colorectal and Anal Carcinomas. In Operative Colorectal Surgery. Block and Moossa (eds.), W.B. Saunders, Co., and Harcourt Brace (publs.), NY pps. 268-284, 1994. 370. Hallahan DE, Bleakman D, Virudachalam S, Lee D, Grdina D, Kufe DW, and Weichselbaum RR: The Role of Intracellular Calcium in the Cellular Response to Ionizing Radiation. Radiat. Res. 138: 392-400, 1994. 371. Hallahan DE, Virudachalam S, Kuchibhotla J, Kufe DW, Weichselbaum RR: Membrane-derived Second Messenger Regulates X-ray-mediated Tumor Necrosis Factor a Gene Induction. Proc. Nat. Acad. Sci. 91: 4897-4901, 1994. 372. Hellman S and Weichselbaum RR: Contempo 1994 Radiation Oncology, J. Amer. Med. Assoc. 271: 1712-1714, 1994. 373. Hallahan DE, Virudachalam S, Kufe DW and Weichselbaum RR: Ketoconazole Attenuates Radiation-Induction of Tumor Necrosis Factor. Int. J. Radiat. Oncol. Biol. Phys. 29: 777-780, 1994. 374. Canaday D, Weichselbaum RR, Astumian RD and Lee RC: Membrane Permeability Changes in Gamma-irradiated Muscle Cells. In Electrical Injury: A Multidisciplinary Approach to Therapy, Prevention and Rehabilitation. Lee, Capelli-Schellpfeffer & Kelley (eds.). Annals of the New York Acad.Sci. (publs.) 720: pps.153-159, 1994. 375. Kharbanda S, Saleem A, Datta R, Yuan ZM, Weichselbaum RR, Kufe D: Ionizing Radiation Induces Rapid Tyrosine Phosphorylation of p34cdc2. Can.Res. 54: 14121414, 1994. 376. Wong W, Mick R, Haraf D, Weichselbaum RR and Vokes EE: Time-dose Relationship for Local Tumor Control Following Alternate Week Concomitant Radiation and Chemotherapy of Advanced Head and Neck Cancer. Int. J. Radiat. Oncol. Biol. Phys. 29: 153-162, 1994. 377. Sweeney PJ, Haraf DJ, Vokes EE, Dougherty M, Weichselbaum RR: Radiation Therapy in Head and Neck Cancer: Indications and Limitations. Semin. Oncol. 21: 296-303, 1994. 378. Kharbanda S, Saleem A, Shafman T, Emoto Y, Blenis J and Weichselbaum RR, Kufe D: Activation of the MAP and pp90rsk Serine /theronine Protein Kinases by Ionizing Radiation. Proc. Natl. Acad. Sci. USA 91: 5416-5420, 1994. 49 379. Weichselbaum RR, Hallahan DE, Fuks Z and Kufe DW: Radiation Induction of Immediate Early Genes: Effectors of the Radiation-Stress Response. Int. J. Radiat. Oncol. 30: 229-234, 1994. 380. Stupp R, Weichselbaum RR, and Vokes E: Combined Modality Therapy of Head and Neck Cancer. Sem. in Oncol. 21: 349-358, 1994. 381. Kharbanda S, Yuan Z-M, Taneja N, Weichselbaum RR, Kufe D: p56/p53lyn Tyrosine Kinase Activation in Mammalian Cells Treated with Mitomycin C. Oncogene 9: 3005-3011, 1994. Kharbanda S, Yuan Z-M, Weichselbaum RR, Kufe D: Activation of the Src-like p56/p53lyn Tyrosine Kinase by Ionizing Radiation. J. Biol. Chem. 269: 20739-20743, 1994. 382. 383. Weichselbaum RR, Hallahan DE, Beckett M A , Mauceri HJ, Lee H, Sukhatme VP, and Kufe D: Gene Therapy Targeted by Radiation Preferentially Radiosensitizes Tumor Cells. Cancer Res. 54:4266-4269, 1994. 384. Mundt AJ, Sibley GS, Williams S, Rubin SJ, Heimann R, Halpern H, and Weichselbaum RR: Patterns of Failure of Complete Responders Following HighDose Chemotherapy and Autologous Bone Marrow Transplantation for Metastatic Breast Cancer: Implications for the Use of Adjuvant Radiation Therapy. Int. J. Radiat. Oncol. Biol. Phys. 30: 151-160, 1994. 385. Fuks Z and Weichselbaum RR: Radiation Therapy. In The Molecular Basis of Cancer. Mendelsohn, Howley, Israel and Liotta (eds.), W.B. Saunders Co. (publs.), Orlando, Fla. pps.401-431, 1994. 386. Vokes EE, Haraf DJ, Mick R, McEvilly J-M, and Weichselbaum RR: Intensified Concomitant Chemoradiotherapy with and without Filgrastim for Poor-Prognosis Head and Neck Cancer. J. Clin. Oncol. 12: pps.2351-2359, 1994. 387. Vokes E, Haraf DJ, Moran W, Wenig B, Brachman D, Rubin S, McEvilly J, Luckett P, Panje W, Weichselbaum RR: Intensified Concomitant Chemoradiotherapy for Poor Prognosis Head and Neck Cancer: A Phase I Study. In Cancer Treatment: An Update. Banzet, Holland, Khayat, & Weil (eds.), Springer-Verlag (publs.), Paris, pps. 283-287, 1994. 388. Kies MS, Haraf DJ, Mittal B, Athanasiadis L, Kozloff M, McEvily J, Mick R, Moran W, Panje W, Pelzer H, Sheehan TK, Weichselbaum RR, Wenig B, and Vokes EE: A Phase II Trial of Induction Cisplatin, 5FU, Leucovorin, and Interferon á 2B (PFL-á) followed by Concurrent Hydrea-5FU and Radiation for Stage IV Squamous Cell Cancers of the Head and Neck (HNC). In Cancer Treatment: An Update. Banzet, Holland, Khayat, & Weil (eds.), Springer-Verlag (publs.), Paris, pps. 207-210, 1994. 50 389. Vijayakumar S, Karrison T, Quadri S, Chan SK, Haraf D, Pandya D, Houghton A, Rubin S, Kalokhe U, Halpern H, Muller-Runkel R, Sutton H, Awan A, and Weichselbaum RR: Localized Prostate Cancer: Use of Serial Prostate-Specific Antigen Measurements During Radiation Therapy- An Update. Onkologie 17: 578585, 1994. 390. Panje WR, Namon AJ, Vokes EE, Haraf DJ, and Weichselbaum RR: Surgical Management of the Head and Neck Cancer Patient following Concomitant Multimodality Therapy. Laryngoscope 105: 97-101, 1995. 391. Spellman JE, Kulesz-Martin MF, Blumenson LE, Beckett MA, and Weichselbaum, RR: Clonal Interactions in a Human Squamous Cell Carcinoma. J. Surg. Res.58: 165174, 1995. 392. Hellman S, and Weichselbaum RR: Oligometastases. J. Clin.Oncol. 13: 8-10, 1995. 393. Sibley GS, Mundt AJ, Goldman S, Nachman J, Reft C, Weichselbaum RR, Hallahan DE, Johnson L: Patterns of Failure Following Total Body Irradiation and Bone Marrrow Transplantation with or without a Radiotherapy Boost for Advanced Neuroblastoma. Int. J. Radiat. Oncol. Biol. Phys. 32: 1127-1135, 1995. 394. Mundt AJ, Sibley G, Williams S, Hallahan D, Nautiyal J, and Weichselbaum RR: Patterns of Failure Following High Dose Chemotherapy and Autologous Bone Marrow Transplantation with Involved Field Radiotherapy for Relapsed/Refractory Hodgkin's Disease. Int. J. Radiat. Oncol. Biol. Phys. 33: 525-528, 1995. 395. Quiet C, Ferguson DJ, Weichselbaum RR, and Hellman S: Natural History of NodeNegative Breast Cancer: A Study of 826 Patients with Long-Term Follow Up. J. Clin. Oncol. 13: 1144-1151, 1995. 396. Weichselbaum RR, Beckett MA, Vokes E, Brachman DG, Haraf D, Hallahan D, and Kufe D.: Cellular and Molecular Mechanisms of Radioresistance. In Head and Neck Cancer, IV, Hong K, Weber R (eds.), Kluwer Acad. Press (publs.) 131-136, 1995. 397. Chen M, Quintans J, Fuks DW, Thompson C, Kufe DW, and Weichselbaum RR: Suppression of Bcl-2 Messenger RNA Production May Mediate Apoptosis After Ionizing Radiation, Tumor Necrosis Factor alpha, and Ceramide. Cancer Res. 55: 991-994, 1995. 398. Datta R, Manome Y, Taneja N, Boise LH, Weichselbaum RR, Thompson CB, Slapak CA and Kufe D: Overexpression of BcL-x-l by Cytotoxic Drug Exposure Confers Resistance to Ionizing Radiation-induced Internucleosomal DNA Fragmentation. Cell Growth and Diff. 6: 363-370, 1995. 399. Haraf DJ, Weichselbaum RR, and Vokes EE: Timing and Sequencing of Chemoradiotherapy. In Head and Neck Cancer, Hong WK, Weber RS (eds.), Kluwer Acad. Publs. pps. 173-198, 1995. 51 400. Weichselbaum RR: Growth Factors Alter the Therapeutic Ratio in Radiotherapy. The Cancer J. Sci. Amer., pps. 28-29, 1995. 401. Collins SL, Dougherty M, Stupp R, Weichselbaum RR, Vokes EE: Head and Neck. In Clinical Oncology, Abeloff, Armitage, Lichter, Niederhuber (eds.), Churchill Levingstone (publs.), NY, Edinburgh, London, Melbourne, Tokoyo, pps. 961-1022, 1995. 402. Vijayakumar S, Quadri SF, Sen S, Vaida F, Ignacio L, and Weichselbaum RR: Measurement of Weekly Prostate Specific Antigen Levels in Patients Receiving Pelvic Radiotherapy for Non-prostatic Malignancies. Int. J. Rad. Oncol. Bio. Phys. 32: 189-195, 1995. 403. Vokes EE, Kies M, Haraf DJ, Mick R, Moran WJ, Kozloff M, Mittal B, Pelzer H, Wenig B, Panje W, and Weichselbaum RR:Induction Chemotherapy Followed by Concomitant Chemoradiotherapy for Advanced Head and Neck Cancer:Impact on the Natural History of the Disease. J. Clin. Oncol. 13: 876-883, 1995. 404. Shafman TD, Saleem A, Kyriakis J, Weichselbaum RR, Kharbanda S, and Kufe DW.: Defective Induction of Stress-Activated Protein Kinase Activity in AtaxiaTelangiectasia Cells Exposed to Ionizing Radiation. Cancer Res. 55: 3242-3245, 1995. 405. Hallahan DE, Vokes EE, Rubin, SJ, O'Brien S, Samuels B, Vijayakumar S, Kufe DW, Phillips R and Weichselbaum RR: Phase I Dose Escalation Study of Tumor Necrosis Factor-á and Concomitant Radiation Therapy. Cancer J. Sci. Amer. 1: 204, 1995. 406. Hallahan DE, Mauceri HJ, Seung LP, Dunphy EJ, Wayne JD, Hanna NN, Toledano A, Hellman S, Kufe DW and Weichselbaum RR: Spatial and Temporal Control of Gene Therapy Using Ionizing Radiation. Nat. Med. 1: 786-791, 1995. 407. Hellman S and Weichselbaum RR: A New Perspective: Radiation Oncology and the New Biol. The Cancer J. Sci. Amer. pps.174-179, 1995. 408. Kharbanda S, Saleem A, Shafman T, Emoto Y, Taneja N, Rubin E, Weichselbaum RR, Woodgett J, Avruch J, Kyriakis J, and Kufe DW: Ionizing Radiation Stimulates a Grb2-mediated Association of the Stress-activated Protein Kinase with Phosphatidylinositol 3-Kinase. J. Biol. Chem. 270: 18871-18874, 1995. 409. Kharbanda S, Ren R, Pandey P, Shafman TD, Feller SM, Weichselbaum RR and Kufe DW: Activation of the c-Abl Tyrosine Kinase in the Stress Response to DNADamaging Agents. Nature 376: 785-788, 1995. 52 410. Mundt AJ, Awan A, Sibley GS, Simon M, Rubin SJ, Samuels B, Wong W, Beckett M, Vijayakumar S, and Weichselbaum RR: Conservative Surgery and Adjuvant Radiation Therapy in the Management of Adult Soft Tissue Sarcoma of the Extremities: Clinical and Radiobiological Results. Int. J. Radiat. Oncol. Biol. Phys. 12: 977-985, 1995. 411. Weichselbaum RR, Wayne JD, Mauceri HJ, Seung LP, Hanna NN, Kharbanda S, Hallahan DE, and Kufe DW: Ionizing Radiation: A Molecular Switch for Gene Therapy. In The Internet Book of Gene Therapy. Sobol RE, and Scanlon KJ (eds.), Appleton & Lange (publs.), pp 205-210, 1995. 412. Haraf DJ, Rubin SJ, Sweeney P, Kuchnir FT, Sutton HG, Chodak GW, and Weichselbaum RR: Photon Neutron Mixed-Beam Radiotherapy of Locally Advanced Prostate Cancer. Int. J. Radiat. Oncol. Biol. Phys. 33:3-14, 1995. 413. Vokes EE, Stupp R, Haraf D, Moran W, Malone D, Wenig B, Sweeney P, and Weichselbaum RR: Hydroxyurea with Continuous Infusion Paclitaxel, 5Fluorouracil, and Concomitant Radiotherapy for Poor-Prognosis Head and Neck Cancer. Sem. Oncol. 22: 47-52, 1995. 414. Vokes EE, Haraf DJ, Stenson K, Stupp R, Malone D, Levin J, Weichselbaum RR: The Role of Paclitaxel in the Treatment of Head and Neck Cancer. Sem. Oncol. 22: 8-12, 1995. 415. Krishnasamy S, Vokes EE, Dohrmann GJ, Mick R, Garcia JC, Kolker JD, Wollman RL, Hekmatpanah J, and Weichselbaum, RR: Concomitant Chemoradiotherapy, Neutron Boost, and Adjuvant Chemotherapy for Anaplastic Astrocytoma and Glioblastoma Multiforme. Cancer Invest. 13: 453-459, 1995. 416. Hallahan DE, Dunphy E, Virudachalam S, Sukhatme V, Kufe DW, and Weichselbaum RR: c-jun and Egr-1 Participate in DNA Synthesis and Cell Survival in Response to Ionizing Radiation Exposure. J. Biol. Chem. 270: 30303-30309, 1995. 417. Seung LP, Mauceri HJ, Beckett MA, Hallahan DE, Hellman S, Kufe DW, Weichselbaum RR: Genetic Radiotherapy Overcomes Tumor Resistance to Cytotoxic Agents. Cancer Res. 55: 5561-5565, 1995. 418. Sibley GS, Mundt AJ, Shapiro C, Jacobs R, Chen GTY, Weichselbaum RR, Vijayakumar S: The Treatment of Stage III Non-small Cell Lung Cancer Using High Dose Conformal Radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 33: 1001-1007, 1995. 419. Weichselbaum RR: The Coleman/Stevenson Article Reviewed: Biological Basis for Radiat. Oncol. Oncol. 10: 411-415, 1996. 53 420. EmotoY, Manome Y, Meinhardt G, Kisaki H, Kharbanda S, Robertson M, Ghayur T, Wong WW, Kamen R, Weichselbaum RR, Kufe D: Proteolytic Activation of Protein Kinase Cδ by an Ice-Like Protease in Apoptotic Cells. EMBO J 14: 61486156, 1996. 421. Mauceri HJ, Hallahan DE, Lee H, Beckett MA, Sukhatme V, Weichselbaum RR: Tumor Size does not Limit Radiation-Inducible Gene Therapy in a Human Xenograft Model. Rad. Oncol. Invest. 3: 238-242, 1996. 422. Kolker JD, and Weichselbaum RR: Radiobiology Update. Advances in NeuroOncology II. 283-305, 1997. 423. Hellman S and Weichselbaum RR: Contempo: Radiation Oncology. JAMA 275: 1852-1853, 1996. 424. Chen LM, Mundt AJ, Powers C, Halpern HJ, Weichselbaum RR: Significance of Family History in Breast Cancer Treated with Breast Conservation Therapy. The Breast J. 2: 238-245, 1996. 425. Haraf DJ, Nodzenski E, Brachman D, Mick R, Montag A, Graves D, Vokes EE, and Weichselbaum RR: HPV and p53 in Head and Neck Cancer: Clinical Correlates and Survival. Clin. Cancer Res. 2: 755-762, 1996. 426. Schwartz JL, Mustafi R, Beckett MA and Weichselbaum RR: DNA Double-strandbreak Rejoining Rates, Inherent Radiation Sensitivity and Human Tumour Response to Radiotherapy. Brit. J. Cancer 74: 37-42, 1996. 427. Nautiyal J, Weichselbaum RR, Vijayakumar S: Radiation Therapy Techniques in the Treatment of Hodgkin’s Disease. Sem. Radiat. Oncol. 6: 172-184, 1996. 428. Schwartz J, Cowan J, Grdina D, Weichselbaum RR: Attenuation of G2 Phase Cell Cycle Checkpoint Control is Associated With Increased Frequencies of Unrejoined Chromosome Breaks in Human Tumor Cells. Radiat. Res. 146: 139-143, 1996. 429. Chmura SJ, Nodzenski E, Weichselbaum RR, and Quintans J: Protein Kinase C Inhibition Induces Apoptosis and Ceramide Production Through Activation of a Neutral Sphingomyelinase. Cancer Res. 56: 2711-2714, 1996. 430. Vokes EE, Mick R, Kies MS, Dolan ME, Malone D, Athanasiadis I, Haraf DJ, Kozloff M, Weichselbaum RR, and Ratain MJ. Pharmacodynamics of Fluorouracil-Based Induction Chemotherapy in Advanced Head and Neck Cancer. J. Clin. Oncol. 14: 1663-1671, 1996. 431. Kharbanda S, Bharti A, Pei D, Wang J, Pandey P, Ren R, Weichselbaum RR, Walsh CT, Kufe D: The Stress Response to Ionizing Radiation Involves c-Abl-dependent Phosphorylation of SHPTP1. Proc. Natl. Acad. Sci. USA 93: 6898-6901, 1996. 54 432. Dritschilo A, Weichselbaum RR, Rhim JS, Guest Editors, Schmidt-Ullrich RK (eds.), Wiley-Liss, A John Wiley & Sons, Inc. (publs.), In Radiation Oncology Investigations, Clinical and Basic Research, Vol. 3, (publs.), 1996. 433. Yuan ZM, Huang Y, Whang Y, Sawyers C, Weichselbaum RR, Kharbanda S, Kufe D: Role for the c-Abl Tyrosine Kinase in Growth Arrest Response to DNA Damage. Nature 382: 272-274, 1996. 434. Pandey P, Raingeaud J, Kaneki M, Weichselbaum RR, Davis RJ, Kufe D, Kharbanda S: Activation of p38 Mitogen-activated protein Kinase by c-Abl-Dependent and Independent Mechanisms. J. Biol. Chem. 271: 23775-23779, 1996. 435. Mauceri HJ, Hanna NN, Wayne JD, Hallahan DE, Hellman S, and Weichselbaum RR: TNF-á Gene Therapy Targeted by Ionizing Radiation Selectively Damages Tumor Vasculature. Cancer Res. 56: 4311-4314, 1996. 436. Kharbanda S, Saleem A, Yuan ZM, Kraeft S, Weichselbaum RR, Chen LB and Kufe D: Nuclear Signaling Induced by Ionizing Radiation Involves Colocalization of the Activated p56/p53lyn Tyrosine Kinase with p34cdc2. Can. Res. 56: 3617-3621, 1996. 437. Hanna NN, Hallahan DE, Wayne JD and Weichselbaum RR: Modification of the Radiation Response by the Administration of Exogenous Genes. Sem. Radiat. Oncol. 6: 1-9, 1996. 438. Dong Y, Wen P, Manome Y, Parr M, Hirshowitz A, Chen L, Hirschowitz EA, Crystal P, Weichselbaum RR, Kufe DW, Fine H: In vivo Replication-deficient Adenovirus Vector-mediated Transduction of the Cytosine Deaminase Gene Sensitizes Glioma Cells to 5-Flurocytosine. Hum. Gene Ther. 7: 713-720, 1996. 439. Heimann R, Powers C, Halpern HJ, Michel AG, Ewing CA, Wyman B, Recant W. Weichselbaum RR: Breast Preservation in Stage I and II Carcinoma of the Breast. The University of Chicago Experience. Cancer 78: 1722-1730, 1996. 440. Datta R, Kojima H, Banach D, Bump NJ, Talanian RV, Alnemri E, Weichselbaum RR, Wong WW, Kufe D: Activation of a Crm-A-insensitive, p35-sensitive Pathway in Ionizing Radiation-induced Apoptosis: J. Biol. Chem. 272: 1965-1969, 1996. 441. Haraf DJ, Weichselbaum RR, Vokes EE: Re-irradiation with Concomitant Chemotherapy of Unresectable Recurrent Head and Neck Cancer: A Potentially Curable Disease. Annls.Oncol. 7: 913-918, 1996. 442. Heimann R, Ferguson D, Powers C, Recant WM, Weichselbaum RR and Hellman S: Angiogenesis as a Predictor of Long-term Survival for Patients with Node-Negative Breast Cancer. J. Natl. Canc. Inst. 88: 1764-1769, 1996.443. 55 443. Hallahan DE, Dunphy E, Kuchibhotla J, Kraft A, Unlap T, Weichselbaum RR: Prolonged c-jun Expression in Irradiated Ataxia Telangiectasia Fibroblasts. Int. J. Radiat. Oncol. Biol. Phys. 36: 355-360, 1996. 444. Chmura SJ, Nodzenski E, Crane MA, Virudachalam S, Hallahan DE, Weichselbaum RR, Quintans J: Cross-talk Between Ceramide and PKC Activity in the Control of Apoptosis in WEHI-231. Adv. Exp. Med. Biol. 406: 39-55, 1996. 445. Seung LP, Weichselbaum RR, Toledano A and Schreiber H: Radiation Can Inhibit Tumor Growth Indirectly while Depleting Circulating Leukocytes. Radiat. Res. 146: 612-618, 1996. 446. Yang FE, Vaida F, Ignacio L, Awan A, Culbert H, Nautiyal J, Kolker J, Sutton H, Halpern H, Weichselbaum RR, Chen GTY, Vijayakumar S: Acute Toxicity in Radiotherapy of Prostate Cancer: Results of a Randomized Study with and without Beam’s-Eye View Three Dimensional Conformal Therapy. Radiat. Oncol. Invest. 4: 231-238, 1996. 447. Quiet CA, Ferguson DJ, Weichselbaum RR, Hellman S: Natural History of Node Positive Breast Cancer: The Curability of Small Cancers with a Limited Number of Positive Nodes. J. Clin. Oncol. 14: 3105-3111, 1996. 448. Kolker JD and Weichselbaum RR: Radiobiology Update. Advances in NeuroOncology II. 283-305, 1997. 449. Hamilton RJ, Sweeney PJ, Pelizzari CA, Yetkin FZ, Holman BL, Garada B, Weichselbaum, RR, Chen GTY: Functional Imaging in Treatment Planning of Brain Lesions. Int. J. Radiat. Oncol. Biol. Phys. 37: 181-188, 1997. 450. Roeske JC, Mundt AJ, Halpern H, Sweeney P, Sutton H, Powers C, Rotmensch J, Waggoner S, Weichselbaum RR: Late Rectal Sequelae Following Definitive Radiation Therapy for Carcinoma of the Uterine Cervix: A Dosimetric Analysis. Int. J. Radiat. Oncol. Biol. Phys. 37: 351-358, 1997. 451. Holland JF, Bast RC, Jr., Morton DL, Frei E, Kufe DW, Weichselbaum RR: Editors, Cancer Medicine 4th Ed., Williams & Wilkins (publs.), 1997 452. Weichselbaum RR, Chen GTY and Hallahan DE: Biological and Physical Basis of Radiation Oncology. Cancer Medicine, 4th Edition, Holland JF, Bast RC, Jr., Morton DL, Frei E, Kufe DW, Weichselbaum RR (eds.). Williams and Wilkins (publs.), pps. 697-726, 1997. 453. Holland JF, Frei E, Kufe DW, Bast RC, Jr., Morton DL, and Weichselbaum RR: Principles of Multidisciplinary Management. In Cancer Medicine, 4th Edition, Holland JF, Bast RC, Jr., Morton DL, Frei E, Kufe DW, Weichselbaum RR (eds.). Williams and Wilkins (publs.), pps. 1395-1401, 1997. 56 454. Yuan ZM, Huang Y, Ishiko T, Kharbanda S, Weichselbaum RR, Kufe D: Regulation of DNA Damage-induced Apoptosis by the c-Abl Tyrosine Kinase. Proc. Nat. Acad. Sci. USA 94: 1437-1440, 1997. 455. Jordan J, Galindo MF, Phrehn JH, Weichselbaum RR, Beckett M, Ghade GD, Roos RP, Leiden JM, Miller RJ: p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures. J. Neurosci. 17: 1397-1405, 1997. 456. Chmura SJ, Nodzenski E, Beckett MA, Kufe DW, Quintans J, Weichselbaum RR: Loss of Ceramide Production Confers Resistance to Radiation-Induced Apoptosis. Can. Res 57: 1270-1275, 1997. 457. Haraf DJ, Weichselbaum RR, Vokes EE: Re-irradiation with Concomitant Chemotherapy of Unresectable Recurrent Head and Neck Cancer: A Potentially Curable Disease. Ann. Oncol. 7: 913-918, 1996. 458. Kharbanda S, Pandey P, Jin S, Inoue S, Bharti P, Yuan ZM, Weichselbaum RR, Weaver D and Kufe D: Functional Interaction between DNA-PK and c-Abl in Response to DNA Damage. Nature 386: 732-735, 1997. 459. Advani SJ, Chmura SJ, Weichselbaum RR: Radiogenetic therapy: On the Interaction of Viral Therapy and Ionizing Radiation for Improving Local Control of Tumors. Semin Oncol. 24: 633-638, 1997. 460. Weichselbaum RR and Kufe D: Gene Therapy of Cancer. Lancet 349: 10-12, 1997. 461. Kharbanda S, Pandey P, Schofield L, Israels S, Roncinske R, Yoshida K, Bharti A, Yuan ZM, Saxena S, Weichselbaum RR, Nalin C, Kufe D: Role for Bcl-xL as an Inhibitor of Cytosolic Cytochrome C Accumulation in DNA Damage-Induced Apoptosis. Proc. Natl. Acad. Sci. 94: 6939-6942, 1997. 462. Johnston PG, Mick R, Recant W, Behan KA, Dolan ME, Ratain MJ, Beckman E, Weichselbaum RR, Allegra CJ, Vokes EE: Thymidylate Synthase Expression and Response to Neoadjuvant Chemotherapy in Patients with Advanced Head and Neck Cancer. J. Natl. Cancer Inst. 89: 308-313, 1997. 463. Mantz CA, Song P, Farhangi E, Nautiyal J, Awan A, Ignacio L, Weichselbaum RR, Vijayakumar S: Potency probability following conformal megavoltage radiotherapy using conventional doses for localized prostate cancer. Int. J. Radiat.Oncol. Biol. Phys. 37: 551-557, 1997. 464. Kharbanda S, Yuan Z-M, Weichselbaum RR, Kufe D: Functional Role for the c-Abl Protein Tyrosine Kinase in the Cellular Response to Genotoxic Stress. Biochem, Biophys. ACTA 1333: 01-07, 1997. 57 465. Heimann R, Ferguson D, Powers S, Suri D, Weichselbaum RR, Hellman S: Race and Clinical Outcome in Breast Cancer in a Series with Long-term Follow-up Evaluation. J. Clin. Oncol. 15: 2329-2337, 1997. 466. Haraf DJ, Swenson K, Witt ME, List M, Sulzen L, Weichselbaum RR, Vokes EE: Concomitant Radiotherapy, Pacitaxel, 5-Fluorouracil. and Hydroxyurea in Patients with Advanced or Recurrent Head and Neck Cancer. Sem. Oncol. 7: S1-34-S1-38, 1997. 467. Mauceri HJ, Seung LP, Grdina WL, Swedberg KM and Weichselbaum RR: Increased Injection Number Enhances Adenoviral Genetic Radiotherapy. Radiat Oncol. Investig. 5: 220-226, 1997. 468. Chmura SJ, Mauceri HJ, Sunil A, Heimann R, Beckett MA, Nodzenski E, Quintans J, Kufe DW, Weichselbaum RR: Decreasing the apoptotic threshold of tumor cells through PKC inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. Cancer Res. 57: 4340-4347, 1997. 469. Yuan ZM, Utsugisawa T, Huang Y, Ishiko T, Nakada S, Kharbanda S, Weichselbaum RR, Kufe D: Inhibition of Phosphatidylinositol 3-kinase by c-Abl in the genotoxic stress response. J. Biol. Chem. 272: 23485-23488, 1997. 470. Hanna NN, Mauceri HJ, Wayne JD, Hallahan DE, Kufe DW, Weichselbaum RR: Virally Directed Cytosine Deaminases/5-Fluorocytosine Gene Therapy Enhances Radiation Response in Human Cancer Xenografts. Cancer Res. 57: 4205-4209, 1997. 471. Mundt AJ, Weichselbaum RR: Tumors of The Soft Tissue, 2nd Edition, DasGupta TK, Chaudhuri PK, (eds.), Appleton & Lange (publs.), Stanford, CT. Radiation Therapy of Soft Tissue Tumors Chapter 17, 1997. 472. Vokes EE, Liebowitz DN, Weichselbaum RR: Nasopharyngeal Carcinoma, Lancet 350: 1087-1091, 1997. 473. Vijayakumar S, Vaida F, Weichselbaum RR, Hellman S: Race and the Will Rogers Phenomenon in Prostate Cancer. Cancer J. Sci. Am. 4: 27-34, 1998. 474. Portugal LG, Goldenberg JD, Wenig BL, Ferrer KT, Nodzenski E, Sabnani JB, Javier C, Weichselbaum RR, Vokes EE: Human Papillomavirus Expression and p53 Gene Mutations in Squamous Cell Carcinoma, Arch. Otolaryngol. Head Neck Surg. 123: 1230-1234, 1997. 475. Mansur DB and Weichselbaum RR: DNA Damage and Repair in the Clinic. In DNA Damage and Repair, 2: Biochemistry, Genetics and Cell Biology. Nickoloff JA, and Hoekstra M.(eds.), Humana Press (publs.) 27: 603-625, 1998. 58 476. Advani SJ, Sibley GS, Song PY, Hallahan DE, Kataoka Y, Roizman B, Weichselbaum RR: Enhancement of Replication of Genetically Engineered Herpes Simplex Viruses by Ionizing Radiation: A New Paradigm for Destruction of Therapeutically Intractable Tumors. Gene Ther. 5: 160-165, 1998. 477. Staba MJ, Mauceri HJ, Kufe DW, Hallahan DE, Weichselbaum RR: Adenoviral TNF-á gene therapy and radiation damage tumor vasculature in a human malignant glioma xenograft. Gene Ther. 5: 293-300, 1998. 478. Yuan ZM, Huang YT, Ishiko T, Nakada S, Utsugisawa T, Kharbanda S, Wang R, Sung P, Shinohara A, Weichselbaum RR, Kufe D: Regulation of Rad51 function by c-Ab1 in response to DNA damage. J. Biol. Chem. 273: 3799-3802, 1998. 479. Brockstein B, Haraf DJ, Stenson K, Fasanmade A, Stupp R, Glisson B, Lippman SM, Ratain MJ, Sulzen L, Klepsch A, Weichselbaum RR, Vokes EE: Phase I Study of Concomitant Chemoradiotherapy with Paclitaxel, Fluorouracil, and Hydroxyurea with Granulocyte Colony-Stimulating Factor Support for Patients with Poor-Prognosis Cancer of the Head and Neck. J. Clin. Oncol. 16: 735-744, 1998. 480. Yuan ZM, Utsugisawa T, Ishiko T, Nakada S, Huang Y, Kharbanda S, Weichselbaum RR, Kufe D: Activation of protein kinase C δ by the c-Abl tyrosine kinase in response to ionizing radiation. Oncogene 16: 1643-1648, 1998. 481. Kharbanda S, Pandey P, Morris PL, Whang Y, Xu Y, Sawant S, Zhu LJ, Kumar N, Yuan ZM, Weichselbaum RR, Sawyers CL, Pandita TK, Kufe D: Functional role for the c-Abl tyrosine kinase in meiosis I. Oncogene 16: 1773-1778, 1998. 482. Yuan ZM, Kharbanda S, Weichselbaum RR, Kufe D: Involvement of the c-Abl tyrosine kinase in the apoptotic response to anticancer agents, Hickman J and Dive C, Cancer Chemotherapy and Apoptosis, Humana Press, 1998. 483. Brockstein B, Weichselbaum RR, Vokes EE: Concomitant and Rapidly Alternating Chemoradiotherapy for Head and Neck Cancer. Advances in Oncology 14: 8-15, 1998. 484. Brockstein B, Haraf DJ, Stenson K, Fasanmade A, Stupp R, Glisson B, Lippman SM, Ratain MJ, Sulzen L, Klepsch A, Weichselbaum RR, Vokes EE: Phase I study of concomitant chemoradiotherapy with paclitaxel, fluorouracil, and hydroxyurea with granulocyte colony-stimulating factor support for patients with poor-prognosis cancer of the head and neck. J. Clin. Oncol. 16: 735-744, 1998. 485. Mauceri HJ, Hanna NN, Beckett MA, Gorski DH, Staba MJ, Stellato KA, Bigelow K, Heimann R, Gately S, Dhanabal M, Soff GA, Sukhatme VP, Kufe DW, Weichselbaum RR: Combined effects of angiostatin and ionizing radiation in antitumour therapy. Nature 394: 287-291, 1998. 59 486. Bishop DK, Ear U, Bhattacharyya A, Calderone C, Beckett MA, Weichselbaum RR, Shinohara A: XRCC3 is required for assembly of Rad51 complexes in vivo. J. Biol. Chem. 273: 21482-21488, 1998. 487. Seetharam S, Nodzenski E, Beckett MA, Heimann R, Cha A, Margulies I, Pastan I, Kufe DW, Weichselbaum RR: Modulation of apoptotic response of a radiationresistant human carcinoma by pseudomonas exotoxin - chimeric protein. Can. Res. 58: 3215-3220, 1998. 488. Bharti A, Kraeft SK, Gounder M, Pandey P, Jin S, Yuan ZM, Lees-Miller SP, Weichselbaum RR, Weaver D, Chen LB, Kufe D, Kharbanda S: Inactivation of DNA-Dependent protein kinase by protein kinase c δ: Implications for apoptosis. Mol. Cell. Biol. 18: 6719-6728, 1998. 489. Kumar S, Pandey P, Bharti A, Jin S, Weichselbaum RR, Weaver D, Kufe D, Kharbanda S: Regulation of DNA-dependent protein kinase by the Lyn tyrosine kinase. J. Biol. Chem. 273: 25654-25658, 1998. 490. Kies MS, Haraf DF, Athanasiadis I, Kozloff M, Mittal B, Pelzer H, Rademaker AW, Wenig B, Weichselbaum RR, and Vokes EE: Induction chemotherapy followed by concurrent chemoradiation for advanced head and neck cancer: improved disease control and survival. J. Clin. Oncol. 16: 2715-2721, 1998. 491. Gorski DH, Mauceri HJ, Salloum RM, Gately S, Hellman S, Beckett MA, Sukhatme VP, Soff GA, Kufe DW, Weichselbaum, RR: Potentiation of the Anti-tumor Effect of Ionizing Radiation by Brief Concomitant Exposures to Angiostatin. Cancer Res. 58: 5686-5689, 1998. 492. Chung TD, Mauceri HJ, Hallahan DE, Yu JJ, Chung S, Grdina WL, Yajnik S, Kufe DW, Weichselbaum RR. Tumor necrosis factor-α based gene therapy enhances radiation cytotoxicity in human prostate cancer. Cancer Gene Ther. 5: 344-349, 1998. 493. Yuan ZM, Kharbanda S, Weichselbaum RR, Kufe D: Involvement of the c-Abl tyrosine kinase in the apoptotic response to anti-cancer agents. In: Hickman J and Dive C, eds. Cancer Chemotherapy and Apoptosis. Humana Press, 1998. 494. Kharbanda S, Yuan ZM, Weichselbaum RR, Kufe D: Determination of cell fate by cAbl activation in the response to DNA damage. Oncogene 17: 3309-3318, 1998. 495. Hallahan DE, Weichselbaum RR: Role of gene therapy in radiation oncology. Cancer Treat Res. 93: 153-167, 1998. 496. Fornace, Jr., AJ, Fuks Z, Weichselbaum RR, Milas L: Radiation Therapy. In The Molecular Basis of Cancer, Second Edition, Editors:Mendelsohn, Howie, Israel & Liotta, pub by Harcourt Health Scs Co & WB Sanders. 2000. 60 497. Mauceri HJ, Hanna NN, Staba MJ, Beckett MA, Kufe DK, Weichselbaum RR: Radiation-Inducible gene therapy. C.R. Acad. Sci. III 322: 225-228, 1999. 498. Schwartz JL, Murnane J, Weichselbaum RR: The Contribution of DNA Ploidy to Radiation Sensitivity in Human Tumour Cell Lines. Br. J. Cancer. 79: 744-747, 1999. 499. Haraf DJ, Kies M, Rademaker AW, Stenson K, Mittal B, Pelzer H, Wenig B, Witt ME, Sulzen L, Weichselbaum RR, Vokes EE: Radiation therapy with concomitant hydroxyurea and fluorouracil in stage II and III head and neck cancer. J. Clin. Oncol. 17: 638-644, 1999. 500. Yuan ZM, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Shioya H, Utsugisawa Y, Yokoyama K, Weichselbaum RR, Shi Y, Kufe D: Role for p300 in stabilization of p53 in the response to DNA damage. J. Biol. Chem. 274: 1883-1886, 1999. 501. Huang Y, Nakada S, Ishiko T, Utsugisawa T, Datta R, Kharbanda S, Yoshida K, Talanian RV, Weichselbaum RR, Kufe D, Yuan ZM: Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage. Mol. Cell. Biol. 19: 2986-2997, 1999. 502. Hannig J, Yu J, Beckett M, Weichselbaum RR, Lee RC: Poloxamine 1107 sealing of radiopermeabilized erythrocyte membranes: Int. J. Radiat. Biol. 75: 379-385, 1999. 503. Lee JS, Jani AB, Pelizzari CA, Haraf DJ, Vokes EE, Weichselbaum RR, Chen GTY: Volumetric visualization of head and neck CT data for treatment planning. Int. J. Radiat. Oncol. Biol. Phys. 44: 693-703, 1999. 504. Advani SJ, Chung SM, Yan Sy, Gillespie GY, Markert JM, Whitley RJ, Roizman B, Weichselbaum RR: Replication-competent, nonneuroinvasive genetically engineered herpes virus is highly effective in the treatment of therapy-resistant experimental human tumors. Cancer Res. 59: 2055-2058, 1999. 505. Vokes EE, Haraf DJ, Brockstein BE, Weichselbaum RR: Paclitaxel, 5-Fluorouracil, Hydroxyurea, and Concomitant Radiation Therapy for Poor-Prognosis Head and Neck Cancer. Semin. Radiat. Oncol. 9: 70-76, 1999. 506. Mantz CA, Nautiyal J, Awan A, Kopnick M, Ray P, Kandel G, Niederberger C, Ignacio L, Dawson E, Fields R, Weichselbaum RR, Vijayakumar S: Potency preservation following conformal radiotherapy for localized prostate cancer: Impact of neoadjuvant androgen blockade, treatment technique, and patient-related factors. Cancer J Sci. Am. 5: 230-236, 1999. 507. Lee MM, Vokes EE, Rosen A, Witt ME, Weichselbaum RR, Haraf DJ: Multimodality therapy in advanced paranasal sinus carcinoma: superior long-term results, Cancer J. Sci. Am. 5: 219-223, 1999. 61 508. Gorski DH, Beckett MA, Jaskowiak NT, Calvin DP, Mauceri HJ, Salloum RM, Seetharam S, Koons A, Hari DM, Kufe DW, Weichselbaum RR: Blockage of the VEGF stress response increases the antitumor effects of ionizing radiation. Cancer Res. 59: 3374-3378, 1999. 509. Yuan ZM, Shioya H. Ishiko T, Sun X, Gu J, Huang YY, Lu H, Kharbanda S, Weichselbaum RR, Kufe D: p73 is regulated by the c-Abl tyrosine kinase in the apoptotic response to DNA damage. Nature 399: 814-817, 1999. 510. Morrison C, Shinohara A, Sonoda E, Yamaguchi-Iwai Y, Takata M, Weichselbaum RR, Takeda S: The essential functions of human Rad51 are independent of ATP hydrolysis. Mol. Cell. Biol. 19: 6891-6897, 1999. 511. Bradley JD, Kataoka Y, Advani S, Chung SM, Arani RB, Gillespie GY, Whitley RJ, Markert JM, Roizman B, Weichselbaum RR: Ionizing radiation improves survival in mice bearing intracranial high-grade gliomas injected with genetically modified herpes simplex virus. Clin. Cancer Res. 5: 1517-1522, 1999. 512. Seetharam S, Staba MJ, Schumm LP, Schreiber K, Schreiber H, Kufe DW, Weichselbaum RR: Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation. Int. J. Onc. 15: 769-773, 1999. 513. Khodarev NN, Advani SJ, Gupta N, Roizman B, Weichselbaum RR: Accumulation of specific RNAs encoding transcriptional factors and stress response proteins against a background of severe depletion of cellular RNAs in cells infected with herpes simplex virus 1. Proc. Natl. Acad. Sci. USA 96: 12062-12067, 1999. 514. Jani AB, Chen MH, Vaida F, Ignacio L, Awan A, Weichselbaum RR, Vijayakumar S: PSA-based outcome analysis after radiation therapy for prostate cancer: A new definition of biochemical failure after intervention. Urology 54: 700-705, 1999. 515. Lee MM, Heimann R, Powers C, Weichselbaum RR, Chen LM: Efficacy of breast conservation therapy in early stage bilateral breast cancer. Breast J. 5: 36-41, 1999. 516. Chmura SJ, Advani SJ, Kufe DW, Weichselbaum RR: Strategies for enhancing viralbased gene therapy using ionizing radiation. Radiat. Oncol. Investig. 7: 261-269, 1999. 517. Markert JM, Gillespie GY, Weichselbaum RR, Roizman B, Whitley RJ: Geneticallyengineered HSV in the treatment of glioma. Rev. Med. Virol. 10: 17-30, 2000. 518. Mauceri HE, Beckett MA, Seetharem S, Kufe DW, Weichselbaum RR: Gene Therapy Targeted by Ionizing Radiation Targets both Tumour Cells and Tumour Vasculature. Radiation Research, 2: Proceedings, 11th Intl Congress of Radiation Res. Dublin, Ireland, 2: 672-675, 2000. 62 519. Advani SJ, Brandimarti R, Weichselbaum RR, Roizman B: The disappearance of cyclins A and B and the increase in the activity of the G2/M phase cellular kinase cdc2 in herpes simplex virus 1 - infected cells requires the expression of α22/US1.5 and UL13 viral genes. J Virol. 74: 8-15, 2000. 520. Connell PP, Ignacio L, McBride RB, Weichselbaum RR, Vijayakumar S: Caution in interpreting biochemical control rates after treatment of prostate cancer: Length of follow-up influences results. Urology 54: 875-879, 1999. 521. Kharbanda S, Saxena S, Yoshida K, Pandey P, Kaneki M, Wang Q, Cheng K, Chen YN, Campbell A, Sudha T, Yuan ZM, Narula J, Weichselbaum RR, Nalin C, Kufe D: Translocation of SAPK/NJK to mitochondria and interaction with Bcl-xL in response to DNA damage. J. Biol. Chem. 275: 322-327, 2000. 522. Kataoka Y, Diamond AM, Weichselbaum RR, Grdina DJ, Mansur DB: Modification of anti-oxidant enzymatic activity by low dose selenium supplementation does not affect radiosensitivity of human malignant glioma cells. Libri Oncol, 27: 2-3, 43-49, 1998. 523. Chmura SJ, Nodzenski E, Kharbanda S, Pandey, P, Quintans, J, Kufe DW, and Weichselbaum RR: Down-Regulation of Ceramide Production Abrogates Ionizing Radiation-Induced Cytochrome c Release and Apoptosis. Mol. Pharmacol, 57: 792796, 2000. 524. Chmura SJ, Dolan ME, Cha A, Mauceri HJ, Kufe DW, Weichselbaum RR: In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo. Clin. Cancer Res. 6: 737-742, 2000. 525. Stupp R, Chung TDK, Collins SL, Dougherty MJ, Weichselbaum RR, Vokes EE: Head and Neck. In Clinical Oncology, 2nd Edition, Abeloff MD, Armitage JO, Lichter AS, Niederhuber JE (eds), Churchill Livingstone (publs), Chapter 54, pps 1248-1316, 2000. 526. Yuan ZM, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Shioya H, Utsugisawa Y, Shi Y, Weichselbaum RR, Kufe DW: Function for p300 and not CBP in the apoptotic response to DNA damage. Oncogene 18: 5714-5717, 1999. 527. Schwartz JL, Jordan R, Kaufmann WK, Rasey J, Russell KJ, Weichselbaum RR: Evidence for the Expression of radiation-induced potentially lethal damage being a p53-dependent process. Int. J. Radiat. Biol. 76: 1037-1043, 2000. 528. Pandey P, Farber R, Nakazawa A, Kumar S, Bharti A, Nalin C, Weichselbaum RR, Kufe D, Kharbanda S: Hsp27 functions as a negative regulator of cytochrome Cdependent activation of procaspase-3. Oncogene 19: 1975-1981, 2000. 63 529. Fortunato JE, Mauceri HJ, Kocharyan H, Song RH, Salloum R, Vosicky J, Swedberg K, Malik S, Abusharif F, Glagov S, Weichselbaum RR, Bassiouny HS: Gene therapy enhances the antiproliferative effect of radiation in intimal hyperplasia. J. Surg. Res. 89: 155-162, 2000. 530. Colorado PC, Torre A, Kamphaus G, Maeshima Y, Hopfer H, Takahashi K, Volk R, Zamborsky ED, Herman S, Sarkar PK, Ericksen MB, Dhanabal M, Simons M, Post M, Kufe DW, Weichselbaum RR, Sukhatme VP, Kalluri R: Anti-angiogenic cues from vascular basement membrane collagen. Cancer Res. 60: 2520-2526, 2000. 531. Kumar V, Sabatini D, Pandey P, Gingras AC, Majumder PK, Kumar M, Yuan ZM, Carmichael G, Weichselbaum RR, Sonenberg N, Kufe D, Kharbanda S: Regulation of the Rapamycin and FKBP-Target 1/Mammalian Target of Rapamycin and Capdependent Initiation of Translation by the c-Abl Protein-tyrosine Kinase. J. Biol. Chem. 275: 10779-10787, 2000. 532. Weichselbaum RR: The Rosen et al Article Reviewed: Biological Basis for Radiation Oncology. Article review. Oncol. 14:5, 761-762, 2000. 533. Bhattacharyya A, Ear US, Koller BH, Weichselbaum RR, Bishop DK: The breast cancer-susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA crosslinking agent cisplatin. J. Biol. Chem. 275: 23899-23903, 2000. 534. Bast, Jr RC, Kufe DW, Pollack RE, Weichselbaum RR, Holland JF, Frei F (eds) Textbook, Cancer Medicine, 5th ed. BC Decker Inc, Hamilton, Ont, Canada, 2000. 535. Mundt AJ, Roeske JC, Weichselbaum RR: Physical and biologic basis of radiation oncology. In: Bast RC, Jr., Kufe DW, Pollack RE, Weichselbaum RR, Holland JE, Frei F (eds). Cancer Medicine, 5th ed., BC Decker, Inc., pp 465-478, 2000. 536. Kufe DW, Advani S, Weichselbaum RR: Cancer gene therapy. In: Bast RC, Jr., Kufe DW, Pollack RE, Weichselbaum RR, Holland JE, Frei F (eds): Cancer Medicine, 5th ed., BC Decker, Inc, 17: 876-889, 2000. 537. Holland JF, Frei E, Kufe DW, Bast RC, Pollock RE, Weichselbaum RR: Principles of Multidisciplinary Management. In Bast RC, Jr., Kufe DW, Pollack RE, Weichselbaum RR, Holland JE, Frei F (eds): Cancer Medicine, 5th Edition, BC Decker, Inc. pp. 986-1000, 2000. 538. Bast RC, Jr., Kufe DW, Pollack RE, Weichselbaum RR, Holland JE, Frei F (eds): Cancer Medicine 5 Review. A companion to Holland-Frei Cancer Medicine, 5th Edition, BC Decker (publs.), 2000. 539. Sun X, Majumder P, Shioya H, Wu F, Kumar S, Weichselbaum R, Kharbanda S, Kufe D: Activation of the cytoplasmic c-Abl tyrosine kinase by reactive oxygen species. J Biol Chem. 275: 17237-17240, 2000. 64 540. Kharbanda S, Pandey P, Yamauchi T, Kumar S, Knaeki M, Kumar V, Bharti A, Yuan ZM, Ghanem L, Rana A, Weichselbaum R, Johnson G, Kufe D: Activation of MEK Kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage. Mol. Cell. Biol. 20: 4979-4989, 2000. 541. Hari D, Beckett MA, Sukhatme VP, Dhanabal M, Nodzenski E, Lu H, Mauceri HJ, Kufe DW, Weichselbaum RR: Angiostatin induces mitotic cell death of proliferating endothelial cells. Mol. Cell Biol. Res. Commun. 3: 277-282, 2000. 542. Advani SJ, Weichselbaum RR, Roizman B: E2F proteins are post translationally modified concomitant with a reduction in nuclear binding activity in cells infected with herpes simplex virus 1. J Virol. 74: 7842-7850, 2000. 543. Hanna NN, Seetharam S, Mauceri HJ, Beckett MA, Jaskowiak NT, Salloum RM, Hari D, Dhanabal M, Ramachandran R, Kalluri R, Sukhatme VP, Kufe, DW, Weichselbaum RR: Antitumor interaction of short course endostatin and ionizing radiation. Cancer J. 6: 287-293, 2000. 544. Yoshida K, Weichselbaum RR, Kharbanda S, Kufe D: Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage. Mol. Cell. Biol. 20: 5370-5380, 2000. 545. Advani SJ, Weichselbaum RR, Roizman B: The role of cdc2 in the expression of herpes simplex virus genes. Proc. Natl. Acad. Sci. USA 97: 10996-11001, 2000. 546. Pelizzari CA, Khodarev NN, Gupta N, Calvin DP, Weichselbaum RR: Quantitative analysis of DNA array autoradiographs. Nucleic Acids Res. 28: 4577-4581, 2000. 547. Vokes EE, Kies MS, Haraf DJ, Stenson K, List M, Humerickhouse R, Dolan ME, Pelzer H, Sulzen L, Witt ME, Hsieh Y-C, Mittal BB, Weichselbaum RR: Concomitant Chemoradiotherapy as Primary Therapy for Locoregionally Advanced Head and Neck Cancer. J. Clin. Oncol. 18: 1652-1661, 2000. 548. Hanning J, Zhang D, Canaday DJ, Beckett MA, Astumian RD, Weichselbaum RR, Lee RC: Surfactant sealing of membranes permeabilized by ionizing radiation. Radiat Res. 154: 171-177, 2000. 549. Brockstein B, Haraf DJ, Stenson K, Sulzen L, Witt ME, Weichselbaum RR, Vokes EE: A phase I-II study of concomitant chemoradiotherapy with paclitaxel (one-hour infusion), 5-fluorouracil and hydroxyurea with granulocyte colony stimulating factor support for patients with poor prognosis head and neck cancer. Ann. Oncol. 11: 721728, 2000. 550. Stenson KM, Haraf DJ, Pelzer H, Recant W, Kies MS, Weichselbaum RR, Vokes EE: The role of cervical lymphadenectomy after aggressive concomitant chemotherapy: the feasibility of selective neck dissection. Arch. Otolaryngol. Head Neck Surg. 126: 950-956, 2000. 65 551. Stenson KM, MacCracken E, List M, Haraf DJ, Brockstein B, Weichselbaum RR, Vokes EE: Swallowing function in patients with head and neck cancer prior to treatment. Arch. Otolaryngol. Head Neck Surg. 126: 371-377, 2000. 552. Pandy P, Saleh A, Nakazawa A, Kumar S, Srinivasula M, Kumar V, Weichselbaum RR, Nalin C, Alnemri ES, Kufe D, Kharbanda S: Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90. EMBO J. 19: 4310-4322, 2000. 553. Weichselbaum RR, Kufe DW, Advani SJ, Roizman BJ: Molecular targeting of gene therapy and radiotherapy. Acta Oncologica Nobel Conference, Stockholm. Acta Oncol. 40: 735-738, 2001. 554. Salloum RM, Jaskowiak NT, Mauceri HJ, Seetharam S, Beckett MA, Koons AM, Hari DM, Gupta VK, Reimer C, Kalluri R, Posner MC, Hellman S, Kufe DW, Weichselbaum RR: NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity. Cancer Res. 60: 6958-6963, 2000. 555. Connell PP, Ignacio L, Haraf D, Awan AM, Halpern H, Abdalla I, Nautiyal J, Jani AB, Weichselbaum RR, Vijayakumar S: Equivalent racial outcome after conformal radiotherapy for prostate cancer: a single departmental experience. J. Clin. Oncol. 19: 54-61, 2001. 556. Terry MA, Hannig J, Carrillo CS, Beckett MA, Weichselbaum RR, Lee RC: Oxidative cell membrane alteration. Evidence for surfactant-mediated sealing. NY Acad. Sci. 888: 274-284, 1999. 557. Pandey P, Farber R, Nakazawa A, Kumar S, Bharti A, Nalin C, Weichselbaum RR, Kufe D, Kharbanda S: Hsp27 functions as a negative regulator of cytochrome cdependent activation of procaspase-3. Oncogene 19: 1975-1981, 2000. 558. Gasior SL, Olivares H, Ear U, Hari DM, Weichselbaum RR, Bishop DK: Assembly of RecA-like recombinases: Distinct roles for mediator proteins in mitosis and meiosis. Proc. Natl. Acad. Sci. USA. 98: 8411-8418, 2001. 559. Mauceri HJ, Salloum RM, Jaskowiak NT, Posner MC, Weichselbaum RR: The isocoumarin, NM-3, enhances antitumor effects of ionizing radiation. Cancer Res. 2: 117-128, 2001. 560. Gupta N, Nodzenski E, Khodarev NN, Yu J, Khorasani L, Beckett MA, Kufe DW, Weichselbaum RR: Angiostatin effects on endothelial cells mediated by ceramide and RhoA. EMBO Rep. 2: 536-540, 2001. 66 561. Mantz CA, Vokes EE, Kies MS, Mittal B, Witt ME, List MA, Weichselbaum RR, Haraf DJ: Sequential induction chemotherapy and concomitant chemoradiotherapy in the management of locoregionally advanced laryngeal cancer. Ann. Oncol. 12: 343347, 2001. 562. Ito Y, Pandey P, Sathyanarayana P, Ling P, Rana A, Weichselbaum RR, Tan TH, Kufe D, Kharbanda S: Interaction of hematopoietic progenitor kinase 1 (HPK1) and c-Abl tyrosine kinase in response to genotoxic stress. J. Biol. Chem. 276: 1813018138, 2001. 563. Mantz CA, Vokes EE, Stenson K, Kies MS, Mittal B, Witt ME, List MA, Weichselbaum RR, Haraf DJ: Induction chemotherapy followed by concomitant chemotherapy in the treatment of locoregionally advanced oropharyngeal cancer. Cancer J. 7: 140-148, 2001. 564. Kies MS, Haraf DJ, Rosen F, Stenson K, List M, Brockstein B, Chung T, Mittal BB, Pelzer H, Portugal L, Rademaker A, Weichselbaum RR, Vokes EE: Concomitant infusional paclitaxel and fluorouracil, oral hydroxyurea, and hyperfractionated radiation for locally advanced squamous head and neck cancer. J. Clin. Oncol. 19: 1961-1969, 2001. 565. Mauceri HJ, Seetharam S, Salloum RM, Vokes EE, Weichselbaum RR: Treatment of head and neck and esophageal xenografts employing alimta and concurrent ionizing radiation. Int. J. Oncol. 19: 833-835, 2001. 566. Sharma A, Mani S, Hanna N, Guha C, Vikram B, Weichselbaum RR, Sparano J, Sood B, Lee D, Regine W, Muhodin M, Valentino J, Herman J, Desimone P, Arnold S, Carrico J, Rockich AK, Warner-Carpenter J, Barton-Baxter M: An open-label, phase I, dose-escalation study of tumor necrosis factor-alpha (TNFerade Biologic) gene transfer with radiation therapy for locally advanced, recurrent or metastatic solid tumors. Hum. Gene Ther. 12: 1109-1131, 2001. 567. Mauceri HJ, Seetharam S, Beckett MA, Lee JY, Gupta VK, Gately S, Stack MS, Brown CK, Swedberg K, Kufe DW, Weichselbaum RR: Tumor production of angiostatin is enhanced following exposure to TNF-α. Int. J. Cancer. 97: 410-415, 2002. 568. Khodarev NN, Park JO, Yu J, Gupta N, Nodzenski E, Roizman B, Weichselbaum RR: Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts. Proc. Natl. Acad. Sci USA. 98: 12665-12670, 2001. 569. Jani AB, Vaida F, Hanks G, Asbell S, Sartor O, Moul JW, Roach M, Brachman D, Kalokhe UI, Muller-Runkel R, Ray P, Ignacio L, Awan A, Weichselbaum RR, Vijayakumar S: Changing face and different countenances of prostate cancer: racial and geographic differences in prostate-specific antigen (PSA), stage, and grade trends in the PSA era. Int. J. Cancer. 96: 363-371, 2001. 67 570. Advani SJ, Hagglund R, Weichselbaum RR, Roizman B: Posttranslational processing of infected cell proteins 0 and 4 of herpes simplex virus 1 is sequential and reflects the subcellular compartment in which the proteins localize. J. Virol. 75: 79047912, 2001. 571. Abdalla I, Ignacio L, Vaida F, Mei-Hsu, Awan A, Mamo C, Weichselbaum RR, Vijayakumar S: Evolution of toxicity after conformal radiation therapy for prostate cancer. Prostate Cancer and Prostatic Dis. 5: 296-303, 2002. 572. Gupta N, Wang H, McLeod TL, Naus CC, Kyurkchiev S, Advani S, Yu J, Perbal B, Weichselbaum RR: Inhibition of glioma cell growth and tumorigenic potential by CCN2(NOV). Mol. Pathol. 54: 293-299, 2001. 573. Skelly CL, Curi MA, Meyerson SL, Woo DH, Hari D, Vosicky JE, Advani SJ, Mauceri HJ, Glagov S, Roizman B, Weichselbaum RR, Schwartz LB: Prevention of restenosis by a herpes simplex virus mutant capable of controlled long-term expression in vascular tissue in vivo. GeneTher. 8: 1840-1846, 2001. 574. Advani SJ, Weichselbaum RR, Roizman B: cdc2 cyclin-dependent kinase binds and phosphorylates herpes simplex virus 1 UL 42 DNA synthesis processivity factor. J. Virol. 75: 10326-10333, 2001. 575. Grdina DJ, Kataoka Y, Murley JS, Hunter N, Weichselbaum RR, Milas L: Inhibition of spontaneous metastases formation by amifostine. Int. J. Cancer 97: 135-141, 2002. 576. Yin L, Ohno T, Weichselbaum RR, Kharbanda S, Kufe D: The novel isocoumarin 2(8-hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl) propionic acid (NM-3) induces lethality of human carcinoma cells by generation of reactive oxygen species. Mol. Cancer Ther. 1: 43-48, 2001. 577. Chmura SJ, Gupta N, Advani SJ, Kufe DW, Weichselbaum RR: Prospects for viralbased strategies enhancing the anti-tumor effects of ionizing radiation. Semin. Radiat. Oncol. 11: 338-345, 2001. 578. Skelly CL, Curi MA, Meyerson SL, Hari D, Vosicky J, Advani SJ, Mauceri H, Glagov S, Roizman B, Weichselbaum RR, Schwartz LB: Prevention of restenosis by herpes simplex virus. Surg. Forum 52: 357-358, 2001. 579. Chung SM, Advani SJ, Bradley JD, Kataoka Y, Vashistha K, Yan SY, Markert JM, Gillespie GY, Whitley RJ, Roizman B, Weichselbaum RR: The use of a genetically engineered herpes simplex virus (R 7020) with ionizing radiation for experimental hepatoma. Gene Ther. 9: 75-80, 2002. 580. Kataoka Y, Murley JS, Khodarev NN, Weichselbaum RR, Grdina DJ: Activation of the nuclear transcription factor kB (NFkB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine. Int. J. Radiat. Oncol. Biol. Phys. 53: 180-189, 2002. 68 581. Khodarev NN, Yu J, Nodzenski E, Murley JS, Kataoka Y, Brown CK, Grdina DJ, Weichselbaum RR: Method of RNA purification from endothelial cells for DNA array experiments. Biotechniques 32: 316, 318, 320, 2002. 582. Advani SJ, Weichselbaum RR: Regional Cancer Gene Therapy: Principles and Progress in Replication-Competent Tumor-Selective Viruses. In: Progress in Oncology, 2002. Hellman S, DeVita V, Rosenberg S (eds.), J. B. Lippincott Co. (publs.), Philadelphia, PA. pp. 54-80, 2002. 583. Posner MC, Vokes EE, Weichselbaum RR: American Cancer Society Atlas of Clinical Oncology. In: Cancer of the Upper Gastrointestinal Tract. Decker BC, Inc. (publs.), 2002. 584. Mauer AM, Weichselbaum RR: Multimodality Therapy for Carcinoma of the Esophagus. In: Cancer of the Upper Gastrointestinal Tract. Decker BC, Inc. (publs.), pps. 157-183, 2002. 585. Gupta VK, Jaskowiak NT, Beckett MA, Mauceri HJ, Grunstein J, Johnson RS, Calvin DA, Nodzenski E, Pejovic M, Kufe DW, Posner MC, Weichselbaum RR: Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer J. 8: 47-54, 2002. 586. Gorski DH, Mauceri HJ, Weichselbaum RR: Strategies for combining gene therapy with ionizing radiation to improve antitumor efficacy. In: Gene Therapy of Cancer, 2nd Edition. Lattime EC and Stanton LG (eds), Academic Press (publs), NYC, NY. Pps. 435-448, 2002. 587. Gupta VK, Park JO, Jaskowiak NT, Mauceri HJ, Seetharam S, Weichselbaum RR, Posner MC: Combined gene therapy and ionizing radiation is a novel approach to treat human esophageal adenocarcinoma. Ann. Surg. Oncol. 9: 500-504, 2002. 588. Park JO, Lopez CA, Gupta VK, Brown CK, Mauceri HJ, Darga TE, Manan A, Hellman S, Posner MC, Kufe DW, Weichselbaum RR: Transcriptional control of viral gene therapy by cisplatin. J. Clin. Invest. 110: 403-410, 2002. 589. Gupta VK, Park JO, Kurihara T, Koons A, Mauceri HJ, Jaskowiak N, Kufe DW, Weichselbaum RR, Posner MC: Selective gene expression using a DF/3MUC1 promoter in a human esophageal adenocarcinoma model. Gene Ther. 10: 206-212, 2003. 590. Rasmussen H, Rasmussen C, Lempicki M, Durham R, Brough D, King CR, Weichselbaum RR: TNFerade biologic: Preclinical toxicology of a novel adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene. Cancer Gene Ther. 9: 951-957, 2002. 69 591. Mauceri HJ, Seetharam S, Beckett MA, Schumm LP, Koons A, Gupta VK, Park JO, Manan A, Lee JY, Montag AG, Kufe DW, Weichselbaum RR: Angiostatin potentiates cyclophosphamide treatment of metastatic disease. Cancer Chemother. Pharmacol. 50: 412-418, 2002. 592. Hogg RP, Honorio S, Martinez A, Agathanggelou A, Dallol A, Fullwood P, Weichselbaum R, Kuo MJ, Maher ER, Latif F: Frequent 3p allele loss and epigenetic inactivation of the RASSF1A tumour suppressor gene from region 3p21.3 in head and neck squamous cell carcinoma. Eur. J. Cancer 38: 1585-1592, 2002. 593. Weichselbaum RR, Kufe DW, Hellman S, Rasmussen HS, King CR, Fischer PH and Mauceri HJ: Radiation induced TNF-α expression: clinical application of transcriptional and physical targeting of gene therapy. Lancet Oncol. 3:665-671, 2002. 594. Grdina DJ, Kataoka Y, Murley JS, Swedberg K, Lee JY, Hunter N, Weichselbaum RR and Milas L: Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice. Semin Oncol. 29:22-28, 2002. 595. Advani SJ, Weichselbaum RR, Whitley RJ and Roizman B: Friendly fire: redirecting herpes simplex virus-1 for therapeutic applications. Clin. Microbiol. Infect. 8: 551-563, 2002. 596. Curi MA, Skelly CL, Meyerson SL, Baldwin ZK, Balasubramanian V, Advani SJ, Glagov S, Roizman B, Weichselbaum RR, and Schwartz LB: Sustained inhibition of experimental neointimal hyperplasia with a genetically modified herpes simplex virus. J. Vasc. Surg. 37: 1294-1300, 2003. 597. Khodarev NN, Yu J, Labay E, Darga T, Brown CK, Mauceri HJ, Yassari R, Gupta N, Weichselbaum RR: Tumour-endothelial interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells. J. Cell Sci. 116:1013-1022, 2003. 598. Khodarev NN, Park J, Kataoka Y, Nodzenski E, Hellman S, Roizman B, Weichselbaum RR, Pelizzari CA: Receiver operating characteristic analysis: a general tool for DNA array data filtration and performance estimation. Genomics 81:202-209, 2003. 599. Gorski DH, Mauceri HJ, Salloum RM, Halpern A, Seetharam S, Weichselbaum RR: Prolonged treatment with angiostatin reduces metastatic burden during radiation therapy. Cancer Res. 63:308-311, 2003. 600. Vokes EE, Stenson K, Rosen FR, Kies MS, Rademaker AW, Witt ME, Brockstein BE, List MA, Fung BB, Portugal L, Mittal BB, Pelzer H, Weichselbaum RR, Haraf DJ: Weekly carboplatin and paclitaxel followed by concomitant paclitaxel, fluorouracil, and hydroxyurea chemoradiotherapy: curative and organ-preserving therapy for advanced head and neck cancer. J Clin. Oncol. 21:320-326, 2003. 70 601. Ren X, Cao C, Zhu L, Yoshida K, Kharbanda S, Weichselbaum RR, Kufe D: Lyn tyrosine kinase inhibits nuclear export of the p53 tumor suppressor. Cancer Biol. Ther., 1:703-708, 2002. 602. Salloum RM, Mauceri HJ, Hanna NN, Gorski DH, Posner MC, Weichselbaum RR: Dual induction of the Epo-Egr-TNF-alpha-plasmid in hypoxic human clone adenocarcinoma produces tumor growth delay. Am. Surg. 69:24-7, 2003. 603. Lopez CA, Park JO, Mauceri HJ, Beckett MA, Weichselbaum RR, Posner MC: Control of gene therapy by MDR1 and EGR1 promoter sequences in transcriptional targeting by chemotherapy. Int. J. Oncol. 24:731-736, 2004. 604. Oh JL, Vokes EE, Kies MS, Mittal BB, Witt ME, Weichselbaum RR, Haraf DJ: Induction chemotherapy followed by concomitant chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal cancer. Ann. Oncol. 14: 564-569, 2003. 605. Advani SJ, Weichselbaum RR, Roizman B: Herpes simplex virus 1 activates cdc2 to recruit topoisomerase IIα for post-DNA synthesis expression of late genes. Proc. Natl. Acad. Sci. USA 100: 4825-4830, 2003. 606. Kufe DW, Pollock RE, Weichselbaum RR, Bast RC, Gansler TS, Holland JF, Frei E: Editors, Cancer Medicine 6th Edition. Decker BC, Inc. (publs), 2003. 607. Mundt AF, Roeske JC, Chung TD, Weichselbaum RR: Principles of Radiation Oncology. In: Cancer Medicine 6th Edition. Kufe DW, Pollock RE, Weichselbaum RR, Bast RC, Gansler TS, Holland JF, Frei E, (eds.). Decker BC, Inc. (publs), Hamilton, Ontario. pps. 585-604, 2003. 608. Advani SJ, Weichselbaum RR, Kufe DW: Cancer Gene Therapy. In: Cancer Medicine 6th Edition. Kufe DW, Pollock RE, Weichselbaum RR, Bast RC, Gansler TS, Holland JF, Frei E, (eds.). Decker BC, Inc. (publs), Hamilton, Ontario. pps. 981997, 2003. 609. Holland JF, Frei E, Kufe DW, Bast RC, Pollock RE, Weichselbaum RR: Principles of Multidisciplinary Management. In: Cancer Medicine 6th Edition. Kufe DW, Pollock RE, Weichselbaum RR, Bast RC, Gansler TS, Holland JF, Frei E, (eds.). Becker BC, Inc. (publs), Hamilton, Ontario. pps. 1079-1084, 2003. 610. Rosen FR, Haraf DJ, Kies MS, Stenson K, Portugal L, List MA, Brockstein BE, Mittal BB, Rademaker AW, Witt ME, Pelzer H, Weichselbaum RR, Vokes EE: Multicenter Randomized Phase II Study of Paclitaxel (1-Hour Infusion), Fluorouracil, Hydroxyurea, and Concomitant Twice Daily Radiation with or without Erythropoietin for Advanced Head and Neck Cancer. Clin. Cancer Res. 9:1689-1697, 2003. 611. Connell PP, Weichselbaum RR: Gene Therapy: The Challenges of Translating Laboratory Research into Clinical Practice. J. Clin. Oncol. 21: 2230-2231, 2003. 71 612. Kufe D, Weichselbaum R: Radiation Therapy – Activation of Gene Transcription and the Development of Genetic Radiotherapy: Therapeutic Strategies in Oncology. Cancer Biol. Ther. 2: 326-329, 2003. 613. Bartelink H, Benz C, Cleveland D, Dorn R, Gralow J, Gradishar WJ, Grant K, Heimann R, Hellman S, Hudis C, Kerbel R, Lippman M, Lung J, Posner MC, Steeg P, Vestal R, Weichselbaum RR, Zetter B: Expedition Inspiration Fund for Breast Cancer Research Meeting 2003. Breast Cancer Res and Treatment 80:139-144, 2003. 614. Kufe DW, Pollock RE, Weichselbaum RR, Bast RC, Holland JF, Frei E: Cancer Medicine 6 Review. Kufe DW, Pollock RE, Weichselbaum RR, Bast RC, Gansler TS, Holland JF, Frei E, (eds.). Becker BC, Inc. (publs), Hamilton, Ontario, 2003. 615. Taneja N, Davis M, Choy JS, Beckett MA, Singh R, Kron SJ, Weichselbaum RR: Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy. J Biol Chem 279: 2273-2280, 2003. 616. Advani SJ, Durand LO, Weichselbaum RR, Roizman B: Oct-1 is posttranslational modified and exhibits reduced capacity to bind cognate sites at late times after infection with herpes simplex virus 1. J Virol 77: 11927-11932, 2003. 617. Senzer N, Mani S, Rosemurgy A, Nemunaitis J, Cunningham C, Guha C, Bayol N, Gillen M, Chu K, Rasmussen C, Rasmussen H, Kufe D, Weichselbaum R, Hanna N: TNFerade biologic, an adenovector with a radiation-inducible promoter carrying the human tumor necrosis factor alpha gene: A phase I study in patients with solid tumors. J. Clin. Oncol. 22:592-601, 2004. 618. Haraf DJ, Rosen FR, Stenson K, Argiris A, Mittal BB, Witt ME, Brockstein BE, List MA, Portugal L, Pelzer H, Weichselbaum RR, Vokes EE: Induction chemotherapy followed by concomitant TFHX chemoradiotherapy with reduced dose radiation in advanced head and neck cancer. Clin Cancer Res 9: 5936-5943, 2003. 619. Khodarev NN, Labay E, Darga T, Yu J, Mauceri H, Gupta N, Kataoka Y and Weichselbaum RR: Endothelial cells co-cultured with wild-type and dominant/negative p53-transfected glioblastoma cells exhibit differential sensitivity to radiation-induced apoptosis. Int J Cancer 109:214-219, 2004. 620. Khodarev NN, Beckett M, Labay E, Darga T, Roizman B and Weichselbaum RR: STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells. Proc Natl Acad Sci USA 101: 17141719, 2004. 72 621. Jani AB, Spelbring D, Hamilton R, Blend MJ, Pelizzari C, Brendler C, Krauz L, Vijayakumar S, Sapra B, Weichselbaum RR: Impact of Radioimmunoscintigraphy on Definition of Clinical Target Volume for Radiotherapy After Prostatectomy. J Nucl Med 45: 238-246, 2004. 622. Jani AB, Blend MJ, Hamilton R, Brendler C, Pelizzari C, Krauz L, Vijayakumar S, Sapra B, Awan A, Weichselbaum RR: Influence of Radioimmunoscintigraphy on Postprostatectomy Radiotherapy Treatment Decision Making. J Nucl Med 45: 571578, 2004. 623. Connell PP, Siddiqui N, Hoffman S, Kuang A, Khatipov EA, Weichselbaum RR, Bishop DK: A Hot Spot for RAD51C Interactions Revealed by a Peptide that Sensitizes Cells to Cisplatin. Cancer Res 64: 3002-3005, 2004. 624. Brown CK, Khodarev NN, Yu J, Moo-Young T, Labay E, Darga TE, Posner MC, Weichselbaum RR, Mauceri HJ. Glioblastoma Cells Block Radiation-Induced Programmed Cell Death of Endothelial Cells. FEBS Lett, 565:167-170, 2004. 625. Greenebaum B, Blossfield K, Hannig J, Carrillo CS, Beckett MA, Weichselbaum RR, Lee RC. Poloxamer 188 Prevents Acute Necrosis of Adult Skeletal Muscle Cells Following High-dose Irradiation. Burns 30:539-547, 2004. 626. Mundt AJ, Vijayakumar S, Nemunaitis J, Sandler A, Schwartz H, Hanna N, Peabody T, Senzer N, Chu K, Rasmussen CS, Kessler PD, Rasmussen HS, Warso M, Kufe DW, Das Gupta T, Weichselbaum RR: A Phase I Trial of TNFerade Biologic in Patients with Soft Tissue Sarcoma in the Extremities. Clin. Cancer Res. 10:57475753, 2004. 627. Lopez CA, Kimchi ET, Mauceri HJ, Park JO, Mehta N, Murphy KT, Beckett MA, Hellman S, Posner MC, Kufe DW, Weichselbaum RR: Chemo-Inducible Gene Therapy: A Strategy to Enhance Doxorubicin Anti-tumor Activity. Mol. Cancer Ther., 3:1167-1175, 2004. 628. Connell PP, Kron SJ, Weichselbaum RR: Relevance and Irrelevance of DNA Damage Response to Radiotherapy. DNA Repair 3:1245-1251, 2004. 629. Brockstein B, Haraf DJ, Rademaker AW, Kies MS, Stenson KM, Rosen F, Mittal BB, Pelzer H, Fung BB, Witt ME, Wenig B, Portugal L, Weichselbaum RR, and Vokes EE: Patterns of Failure, Prognostic Factors and Survival in Locoregionally Advanced Head and Neck Cancer Treated with Concomitant Chemoradiotherapy: a 9-year, 337Patient, Multi-Institutional Experience. Annals of Oncology 15:1179-1186, 2004. 630. Yamini B, Yu X, Gillespie GY, Kufe DW, Weichselbaum RR: Transcriptional Targeting of Adenovirally Delivered Tumor Necrosis Factor by Temozolomide in Experimental Glioblastoma. Cancer Res. 64:6381-6384, 2004. 73 631. Khodarev NN, Kataoka Y, Murley J, Weichselbaum RR, Grdina DJ: Interaction of Amifostine and Ionizing Radiation on Transcriptional Patterns of Apoptotic Genes Expressed in Human Microvascular Endothelial Cells (HMEC). Int. J. Radiat. Oncol. Biol. Phys. 60:553-563, 2004. 632. Chmura SJ, Garofalo M, and Weichselbaum, RR: Radiosensitization by Gene Therapy. In: Cancer Gene Therapy. Curiel DT, Douglas JT (eds.), Humana Press Inc. (publs.), Totowa, NJ, pp. 349-366, 2004. 633. Chmura SJ, Silverberg W, and Weichselbaum RR: Principles and Applications of Radiation Oncology. In: Urologic Oncology. Richie JP, D’Amico A (eds.), Elsevier Saunders (publs.), Philadelphia, PA, pp. 39-50, 2004. 634. Mehta N, Mauer AM, Hellman S, Haraf DJ, Cohen EE, Vokes EE, Weichselbaum RR: Analysis of Further Disease Progression in Metastatic Non-Small Cell Lung Cancer: Implications for Locoregional Treatment. Int. J. Oncol. 25:1677-1683, 2004. 635. Hellman S and Weichselbaum RR: Importance of local control in an era of systemic therapy. Nature Clin Pract Oncol. 2: 60-61, 2005. 636. Baldwin ZK, Chandiwal A, Balasubramanian V, Pearce BJ, Curi MA, Skelly CL, Huang WW, Vosicky JE, Roizman B, Weichselbaum RR, Schwartz LB: Modulation of vascular remodeling induced by a brief intraluminal exposure to the recombinant R7020 strain of Herpes simplex-1. J Vasc Surg 41: 115-121, 2005. 637. Milano MT, Vokes EE, Salama JK, Stenson KM, Kao J, Witt ME, Mitta BB, Argiris A, Weichselbaum RR, Haraf DJ: Twice-daily reirradiation for recurrent and second primary head and neck cancer with gemcitabine, paclitaxel, and 5-fluorouracil chemotherapy. Int J Radiat Oncol Biol Phy 61:1096-1106, 2005. 638. Kimchi ET, Posner MC, Park JO, Darga TE, Kocherginsky M, Karrison T, Hart J, Smith KD, Mezhir JJ, Weichselbaum RR, and Khodarev NN: Progression of Barrett’s Metaplasia to Adenocarcinoma is Associated with the Suppression of the Transcriptional Programs of Epidermal Differentiation. Cancer Res 65: 3146-3154, 2005. 639. Raina D, Pandey P, Ahmad R, Bharti A, Ren J, Kharbanda S, Weichselbaum R, and Kufe D: c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J Biol Chem 280: 11147-11151, 2005. 640. Weichselbaum RR: Radiation’s outer limits. Nature Med 11: 477-478, 2005. 641. Weichselbaum RR: How does antiangiogenic therapy affect brain tumor response to radiation? Nature Clin Prac Oncol (Commentary) 2: 232-233, 2005. 74 642. Weichselbaum RR: (Foreward). In: Intensity Modulated Radiation Therapy: A Clinical Perspective. Mundt AJ and Roeske JC (eds). BC Decker, Inc (publs), Hamilton, London, pg xi, 2005. 643. Mauceri H, Murphy K, Wardak A, Beckett M, Lopez C, Mehta N, Kimchi E, Salloum R, Jaskowiak N, Posner M, Ohno T, Kufe D, and Weichselbaum RR: Forphenicinol enhances the anti-tumor effects of cyclophosphamide in a model of squamous cell carcinoma. Cancer Chemother. Pharmacol., 56: 317-21, 2005. 644. Weichselbaum RR: Bugging the intestinal response to radiation. PNAS 102:1336313364, 2005. 645. Mezhir JJ, Advani SJ, Smith KD, Darga TE, Poon APW, Schmidt H, Posner MC, Roizman B and Weichselbaum RR: Ionizing radiation activates late herpes simplex virus 1 promoters via the p38 pathway in tumors treated with oncolytic viruses. Cancer Res 65:9479 – 9484, 2005. 646. Mezhir JJ, Schmidt H, Yamini B, Senzer NN, Posner MC, Kufe DW, and Weichselbaum RR: Chemo-inducible gene therapy. Anticancer Drugs 16:10531058, 2005. 647. Mezhir JJ, Smith KD, Posner MC, Senzer N, Yamini B, Kufe DW, and Weichselbaum RR: Ionizing radiation: a genetic switch for cancer therapy. Cancer Gene Ther 13: 1-6, 2006. 648. Smith KD, Mezhir JJ, Bickenbach K, Veerapong J, Charron J, Posner MC, Roizman B, and Weichselbaum RR: Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by ∆γ1 34.5 mutants of herpes simplex virus 1. J Virol 80:1110-1120, 2006. 649. Kufe DW, Bast RC, Hait WN, Hong WK, Pollock RE, Weichselbaum RR, Holland JF, and Frei E: Editors, Cancer Medicine 7th Edition. Decker BC, Inc. (publs), Hamilton, London, 2006. 650. Holland JF, Frei E, Kufe DW, Bast RC, Pollock RE, Weichselbaum RR, Hong WK, and Hait WN: Cardinal Manifestations of Cancer. In: Cancer Medicine 7th Edition. Kufe DW, Bast RC, Hait WN, Hong WK, Pollock RE, Weichselbaum RR, Holland JF, and Frei E (eds). Decker BC, Inc. (publs), Hamilton, London, pps. 3-5, 2006. 651. Mundt AJ, Roeske JC, Chung TD, and Weichselbaum RR: Principles of Radiation Oncology. In: Cancer Medicine 7th Edition. Kufe DW, Bast RC, Hait WN, Hong WK, Pollock RE, Weichselbaum RR, Holland JF, and Frei E (eds). Decker BC, Inc. (publs), Hamilton, London, pps. 517-536, 2006. 75 652. Advani SJ, Weichselbaum RR, and Kufe DW: Gene Therapy. In: Cancer Medicine 7th Edition. Kufe DW, Bast RC, Hait WN, Hong WK, Pollock RE, Weichselbaum RR, Holland JF, and Frei E (eds). Decker BC, Inc. (publs), Hamilton, London, pps. 860-878, 2006. 653. Holland JF, Frei E, Kufe DW, Bast RC, Pollock RE, Weichselbaum RR, Hong WK, and Hait WN: Principles of Multidisciplinary Management. In: Cancer Medicine 7th Edition. Kufe DW, Bast RC, Hait WN, Hong WK, Pollock RE, Weichselbaum RR, Holland JF, and Frei E (eds). Decker BC, Inc. (publs), Hamilton, London, pps. 935-940, 2006. 654. Shafaee Z, Schmidt H, Du W, Posner M, Weichselbaum RR: Cyclopamine increases the cytotoxic effects of paclitaxel and radiation but not cisplatin and gemcitabine in Hedgehog expressing pancreatic cancer cells. Cancer Chemother Pharmacol 58(6):765770, 2006. 655. Milano MT, Vokes EE, Kao J, Jackson W, List MA, Stenson KM, Witt ME, Dekker A, Maccracken E, Garofalo MC, Chmura SJ, Weichselbaum RR, Haraf DJ: Intensitymodulated radiation therapy in advanced head and neck patients treated with intensive chemoradiotherapy: preliminary experience and future directions. Int J Oncol 28: 11411151, 2006. 656. Connell PP, Jayathilaka K, Haraf DJ, Weichselbaum RR, Vokes EE, Lingen MW: Pilot study examining tumor expression of RAD51 and clinical outcomes in human head cancers. Int J Oncol 28: 1113-1119, 2006. 657. Jani AB, Feinstein JM, Pasciak R, Krengel S, and Weichselbaum RR: Role of external beam radiotherapy with low-dose-rate brachytherapy in treatment of prostate cancer. Urology 67: 1007-1011, 2006. 658. Kao J, Milano MT, Javaheri A, Garofalo MC, Chmura SJ, Weichselbaum RR, and Kron SJ: Gamma-H2AX as a therapeutic target for improving the efficacy of radiation therapy. Curr Cancer Drug Targets 6:197-205, 2006. 659. Advani SJ, Mezhir JJ, Roizman B, Weichselbaum RR: ReVOLT: Radiation-Enhanced Viral Oncolytic Therapy. Int. J. Radiation Oncology Biol. Phys. 66:637-646, 2006. 660. Mezhir JJ, Smith KD, Kimchi ET, Park JO, Lopez CA, Mauceri HJ, Beckett MA, Hellman S, Weichselbaum RR, Posner MC: Establishment of a Syngeneic Model of Hepatic Colorectal Oligometastases. J. Surg. Res. 136: 288-293, 2006. 661. Zhang B, Bowerman NA, Salama JK, Schmidt H, Spiotto MT, Schietinger A, Yu P, Fu YX, Weichselbaum RR, Rowley DA, Kranz DM, and Schreiber H: Induced Sensitization of Tumor Stroma Leads to Eradication of Established Cancer by T Cells. J Exp Med. 204:49-55, 2007. 76 662. Advani SJ, Weichselbaum RR, Chmura SJ: Enhancing Radiotherapy with Genetically Engineered Viruses. JCO 25:4090-4095, 2007. 663. Skelly CL, Chandiwal A, Vosicky JE, Weichselbaum RR, Roizman B: Attenuated Herpes Simplex Virus 1 Blocks Arterial Apoptosis and Intimal Hyperplasia Induced by Balloon Angioplasty and Reduced Blood Flow. PNAS 104:12474-12478, 2007. 664. Katdare M, Efimova EV, Labay E, Khodarev NN, Darga TE, Garofalo M, Nakamura S, Kufe DW, Posner MC, and Weichselbaum RR: Diverse TNFα-induced Death Pathways are Enhanced by Inhibition of NF-κB. Int J Oncol 31: 1519-1528, 2007. 665. Sharma RR and Weichselbaum RR: Angiogenesis Inhibition: The Next Frontier in Multimodal Therapy for Glioblastoma Multiforme. Nat Clin Pract Oncol 4:454-455, 2007. 666. MacGill RS, Davis TA, Macko J, Mauceri HJ, Weichselbaum RR, and King CR: Local Gene Delivery of Tumor Necrosis Factor Alpha Can Impact Primary Tumor Growth and Metastases through a Host-Mediated Response. Clin Exp Metastasis 24: 521-531, 2007. 667. Yamini B, Yu X, Dolan ME, Wu MH, Kufe DW, and Weichselbaum RR: Inhibition of Nuclear Factor-κB Activity by Temozolomide Involves O6-Methylguanine Induced Inhibition of p65 DNA Binding. Cancer Res 67: 6889-6898, 2007. 668. Veerapong J, Bickenbach KA, Shao MY, Smith KD, Posner MC, Roizman B, Weichselbaum RR: Systemic Delivery of γ1 34.5-Deleted Herpes Simplex Virus-1 Selectively Targets and Treats Distant Human Xenograft Tumors That Express High Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Activity. Cancer Res 67:8301-8306, 2007. 669. Smith KD, Shao MY, Posner MC, Weichselbaum RR. Tumor genotype determines susceptibility to oncolytic HSV mutant viruses: Strategies for clinical application. Future Oncol 3: 545-556, 2007. 670. Khodarev NN, Minn AJ, Efimova EV, Darga TE, Labay E, Beckett M, Mauceri HJ, Roizman B, Weichselbaum RR. Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells. Cancer Res 67: 9214-9220, 2007. 671. Roeske JC, Nunez L, Loggarth, Labay E, Weichselbaum RR. Characterization of the theorectical radiation dose enhancement from nanoparticles. Technol Cancer Res Treat 6: 395-402, 2007. 672. Yamini B, Yu X, Pytel P, Galanopoulos N, Rawlani V, Veerapong J, Bickenbach K, Weichselbaum RR: Adenovirally Delivered Tumor Necrosis Factor-α Improves the Antiglioma Efficacy of Concomitant Radiation and Temozolomide Therapy. Clin Cancer Res 20:6217-6223, 2007. 77 673. Mell LK, Weichselbaum RR: More on cetuximab in head and neck cancer. N Engl J Med. 357(21):2201-2, 2007. (peer-reviewed letter) 674. Bickenbach KA, Veerapong J, Shao MY, Mauceri HJ, Posner MC, Kron SJ, Weichselbam RR. Resveratrol is an effective inducer of CArG-Driven TNF-a gene therapy. Cancer Gene Ther 15:133-139, 2008. 675. Liauw SL, Weichselbaum RR, Zagaja GP, Jani AB: Salvage Radiotherapy After Postprostatectomy Biochemical Failure: Does Pretreatment Radioimmunoscintigraphy Help Select Patients with Locally Confined Disease? Int J Radiat Oncol Biol Phys. 71:1316-21, 2008. 676. Seiwert TY, Haraf DJ, Cohen EE, Stenson K, Witt ME, Dekker A, Kocherginsky M, Weichselbaum RR, Chen HX, Vokes EE. Phase I study of bevacizumab added to fluorouracil- and hydroxyurea-based concomitant chemoradiotherapy for poor-prognosis head and neck cancer. J Clin Oncol. 26(10):1732-41, 2008. 677. Salama JK. Chmura SJ, Mehta N, Yenice KM, Stadler WM, Vokes EE, Haraf DJ, Hellman S, Weichselbaum RR. An Initial Report of a Radiation Dose Escalation Trial in Patients with One to Five Sites of Metastatic Disease. Clin Cancer Res. 14: 52555259, 2008. 678. MacDermed DM, Weichselbaum RR, Salama JK. A rationale for the targeted treatment of oligometastases. J Surg Oncol. (Review) 98(3):202-206, 2008. 679. Veerapong J, Bickenbach KA, Weichselbaum RR. Radiosensitization in Viral Gene Therapy. In: Viral Therapy of Cancer, 1st ed. Harrington KJ, Vile RG, and Pandha HS (eds), John Wiley & Sons Ltd (publs), 313-326, 2008. 680. Al-Hallaq H, Chmura SJ, Weichselbaum RR. Magnetic Resonance Imaging (MRI) Identifies Multifocal and Multicentric Disease in Breast Cancer Patients Eligible for Partial Breast Irradiation (PBI). Cancer 113:2408-2414, 2008. 681. Jayathilaka K, Sheridan SD, Bold T, Bochenska K, Logan HL, Weichselbaum RR, Bishop DK, Connell PP: A chemical compound that stimulates the human homologous recombination protein RAD51. Proc Nat Acad Sci USA 105:15848-15853, 2008. PMCID: PMC2572930. 682. Weichselbaum RR, Ishwaran H, Yoon T, Nuyten DS, Baker SW, Khodarev N, Su AW, Shaikh AY, Roach P, Kreike B, Roizman B, Bergh J, Pawitan Y, van de Vijver MJ, Minn AJ: An Interferon-Related Gene Signature for DNA Damage Resistance is a Predictive Marker for Chemotherapy and Radiation for Breast Cancer. Proc Nat Acad Sci USA 105(47):18490-18495, 2008. PMCID: PMC2587578. 683. Weichselbaum RR: MUCing Around with Tumor Suppression (Commentary). Cancer Biol and Ther 7:1968-1969, 2008. 78 684. Mauceri HJ, Beckett MA, Liang H, Sutton HG, Pitroda S, Galka E, Efimova E, Darga T, Khodarev NN, King CR, Posner MC, Hellman S, Kufe DW, Weichselbaum RR: Translational Strategies Exploiting TNF-α that Sensitize Tumors to Radiation Therapy. Cancer Gene Ther 16(4):373-381, 2009. 685. Gutt R, Liauw SL, and Weichselbaum RR: Adjuvant radiotherapy for resected pancreatic cancer. Nat Clin Pract Gastroenterol Hepatol 6(1):38-46, 2009. 686. Haney CR, Parasca AD, Fan X, Bell RM, Zamora MA, Karczmar GS, Mauceri HJ, Halpern HJ, Weichselbaum RR, and Pelizzari CA: Characterization of Response to Radiation Mediated Gene Therapy by Multi-Modality Imaging. Magn Reson Med 62(2):348-356, 2009. 687. Skelly CL, Weichselbaum RR, et al: Concomitant proliferation and caspase-3 mediated apoptosis in response to low shear stress and balloon injury. J Surg Research 161(1):146-155, 2010. 688. Uriel S, Labay E, Francis-Sedlak M, Moya ML, Weichselbaum RR, Ervin N, Cankova Z, Brey EM. Extraction and Assembly of Tissue-Derived Gels for Cell Culture and Tissue Engineering. Tissue Eng Part C Methods 15(3):309-321, 2009. 689. Khodarev NN, Pitroda SP, Beckett MA, MacDermed DM, Huang L, Kufe DW, and Weichselbaum RR. MUC1-Induced Transcriptional Programs Associated with Tumorigenesis Predict Outcome in Breast and Lung Cancer. Cancer Res 69(7):2833-7, 2009. 690. Efimova EV, Liang H, Pitroda SP, Labay E, Darga TE, Levina V, Lokshin A, Roizman B, Weichselbaum RR, and Khodarev NN. Radioresistance of Stat1 Over-expressing Tumor Cells is Associated with Suppressed Apoptotic Response to Cytotoxic Agents and Increased IL6 - IL8 Signaling. Int J Radiat Biol 85(5):421-431, 2009. PMCID: PMC2690884. 691. Pitroda SP, Khodarev NN, Beckett MA, Kufe DW, and Weichselbaum RR. MUC1Induced Alterations in a Lipid Metabolic Gene Network Predict Response of Human Breast Cancers to Tamoxifen Treatment. PNAS 106(14):5837-41, 2009. PMCID: PMC2656554. 692. Liauw SL, Fricano J, Correa D, Weichselbaum RR, and Jani AB. Dose-Escalated Radiation Therapy for Intermediate-Risk Prostate Cancer: Patient Selection for Androgen Deprivation Therapy Using Percentage of Positive Cores. Cancer 115(8):1784-1790, 2009. 693. Lee Y, Auh S, Wang Y, burnette B, Wang Y, Meng Y, Beckett M, Sharma R, Chin R, Tu T, Weichselbaum R, and Fu Y. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: Changing strategies for cancer treatment. Blood 114(3):589-595, 2009. 79 694. Cohen EE, Baru J, Huo D, Haraf DJ, Crowley M, Witt ME, Blair EA, Weichselbaum RR, Rosen F, Vokes EE, Stenson K. Efficacy and safety of treating T4 oral cavity tumors with primary chemoradiotherapy. Head Neck. 31(8):1013-1021, 2009. 695. Weichselbaum RR and Kufe D. Translation of the radio- and chemo- inducible TNFerade vector for the treatment of human cancers. Cancer Gene Therapy 16(8):609619, 2009. 696. Liauw SL, Weichselbaum RR, Rash C, Correa D, Al-Hallaq HA, Pelizzari CA, Jani AB. Biochemical Control and Toxicity after Intensity-Modulated Radiation Therapy for Prostate Cancer. Technol Cancer Res Treat 8(3): 201-206, 2009. 697. Spiquel LR, Chandiwal A, Vosicky JE, Weichselbaum RR, and Skelly CL. Concomitant Proliferation and Caspase-3 Mediated Apoptosis in Response to Low Shear Stress and Balloon Injury, J Surg Res, 2010; 161(1):146-155. 698. Khodarev NN, Roach P, Pitroda SP, Golden DW, Bhayani M, Shao MY, Darga TE, Beveridge MG, Sood RF, Sutton HG, Beckett MA, Mauceri HJ, Posner MC, and Weichselbaum RR. STAT1 Pathway Mediates Amplification of Metastatic Potential and Resistance to Therapy. PLoS ONE. 4(6): e5821, 2009. PMCID: PMC2688034. 699. Liauw SL, Stadler WM, Correa D, Weichselbaum RR, Jani AB. Dose-Escalated Radiotherapy for High-Risk Prostate Cancer: Outcomes in Modern Era with Short-Term Androgen Deprivation Therapy. Int J Radiat Oncol Biol Phys. 2010; 77(1):125-130. PMCID: PMC3049990. 700. Valuckaite V, Zaborina O, Long J, Hauer-Jensen M, Wang J, Holbrook C, Zaborin A, Drabik K, Katdare M, Mauceri H, Weichselbaum RR, Firestone MA, Lee KY, Chang EB, Matthews JB, Alverdy JC. Oral PEG 15-20 Protects the Intestine Against Radiation: Role of Lipid Rafts. Am J Physiol Gastrointest Liver Physiol. 297(6):G1041-1052, 2009. PMCID: PMC2850088. 701. Khodarev N, Ahmad R, Rajabi H, Pitroda S, Kufe T, McClary C, Joshi D, MacDermed D, Weichselbaum RR and Kufe D. Cooperativity of the MUC1 Oncoprotein and STAT1 Pathway in Poor Prognosis Human Breast Cancer. Oncogene 29(6):920-929 2009. PMCID: PMC2820589. 702. Pitroda SP, Wakim BT, Sood RF, Beveridge MG, Beckett MA, MacDermed DM, Weichselbaum RR, Khodarev NN. STAT1 Dependent Expression of Energy Metabolic Pathways Links Tumour Growth and Radioresistance to the Warburg Effect. BMC Medicine 7:68, 2009. PMCID: PMC2780454. 703. Mell LK, Dignam JJ, Salama JK, Cohen EE, Polite BN, Dandekar V, Bhate AD, Witt ME, Haraf D, Mittal BB, Vokes EE, Weichselbaum RR. Predictors of competing mortality in advanced head and neck cancer. J Clin Oncol 28(1):15-20, 2010. 80 704. Maitland ML, Lou XJ, Ramirez J, Desai AA, Berlin DS, McLeod HL, Weichselbaum RR, Ratain MJ, Altman RB, Klein TE. Vascular Endothelial Growth Factor Pathway. Pharmacogenet Genomics. 2010; 20(5):346-9. 705. Hong WK, Bast RC, Hait WN, Kufe DW, Pollock RE, Weichselbaum RR, Holland JF, and Frei E: Editors, Cancer Medicine 8th Edition. People’s Medical Publishing HouseUSA (publs), Shelton, Connecticut 2010. 706. Holland JF, Frei E, Hong WK, Kufe DW, Bast RC, Hait WN, Pollock RE, Weichselbaum RR: Cardinal Manifestations of Cancer. In: Cancer Medicine 8th Edition. Hong WK, Bast RC, Hait WN, Kufe DW, Pollock RE, Weichselbaum RR, Holland JF, and Frei E (eds). People’s Medical Publishing House-USA (publs), Shelton, Connecticut, pps. 1-3, 2010. 707. Salama JK, Dewhirst MW and Weichselbaum RR: Principles of Radiation Oncology. In: Cancer Medicine 8th Edition. Hong WK, Bast RC, Hait WN, Kufe DW, Pollock RE, Weichselbaum RR, Holland JF, and Frei E (eds). People’s Medical Publishing HouseUSA (publs), Shelton, Connecticut, pps. 510-527, 2010. 708. Advani SJ, Weichselbaum RR, and Kufe DW: Gene Therapy. In: Cancer Medicine 8th Edition. Hong WK, Bast RC, Hait WN, Kufe DW, Pollock RE, Weichselbaum RR, Holland JF, and Frei E (eds). People’s Medical Publishing House-USA (publs), Shelton, Connecticut, pps. 759-775, 2010. 709. Holland JF, Frei E, Hong WK, Kufe DW, Bast RC, Pollock RE, Weichselbaum RR and Hait WN: Multidisciplinary Management. In: Cancer Medicine 8th Edition. Hong WK, Bast RC, Hait WN, Kufe DW, Pollock RE, Weichselbaum RR, Holland JF, and Frei E (eds). People’s Medical Publishing House-USA (publs), Shelton, Connecticut, pps. 823829, 2010. 710. Meng Y, Mauceri HJ, Khodarev NN, Darga TE, Pitroda SP, Beckett MA, Kufe DW, Weichselbaum RR. Ad.Egr-TNF and Local Ionizing Radiation Suppresses Metastases by Interferon-β-Dependent Activation of Antigen-Specific CD8+ T Cells. Mol Ther. 2010; 18(5):912-20. PMCID: PMC2890103. 711. Meng Y, Beckett MA, Liang H, Mauceri HJ, Rooien NV, Cohen KS, Weichselbaum RR. Blockade of Tumor Necrosis Factor α Signaling in Tumor-Associated Macrophages: A New Radiosensitizing Strategy. Cancer Res 70:1534-43, 2010. 712. MacDermed D, Khodarev NN, Pitroda S, Edwards DC, Pelizzari CA, Huang L, Kufe DW and Weichselbaum RR. MUC1-Associated Proliferation Signature Predicts Outcomes in Lung Adenocarcinoma Patients. BMC Med Genomics 2010, 6; 3:16. PMCID: PMC2876055. 713. Lee Y, Yang X, Huang Y, Fan H, Zhang Q, Wu, Y, Li J, Hasina R, Cheng C, Lingen M, Gerstein M, Weichselbaum RR, Xing HR, and Lussier Y. Network Modeling Identifies 81 Molecular Functions Targeted by miR-204 to Suppress Head and Neck Tumor Metastasis. PLoS Comput Biol 6(4): e1000730. 2010. PMCID: PMC2848541. 714. Gutt R, Tonlaar N, Kunnavakkam R, Karrison T, Weichselbaum RR, and Liauw SL. Statin Use and Risk of Prostate Cancer Recurrence in Men Treated with Radiation Therapy. J Clin Oncol. 2010, 28(16):2653-2659. 715. Huang L, Liao X, Beckett M, Li Y, Khanna KK, Wang Z, Kharbanda S, Weichselbaum RR, and Kufe D. MUC1-C Oncoprotein Interacts Directly with ATM and Promotes the DNA Damage Response to Ionizing Radiation. Genes Cancer. 1(3):239-250, 2010. PMCID: PMC2943399. 716. Nichols MA, Mell LK, Hasselle MD, Karrison TG, Macdermed D, Meriwether A, Witt ME, Weichselbaum RR, and Chmura SJ. Outcomes in Black Patients with Early Breast Cancer Treated with Breast Conservation Therapy. Int J Radiat Oncol Biol Phys. 2011, 79(2):392-399. 717. Mathew B, Huang Y, Jacobson JR, Gerhold LM, Wang T, Moreno-Vinasco L, Lang G, Chen C, LaRiviere PJ, Mauceri H, Sammani S, Hussain AN, Dudek SM, Natarajan V, Lussier YA, Weichselbaum RR, Garcia JGN. Simvastatin Attenuates Radiation-Induced Murine Lung Injury and Dysregulated Lung Gene Expression. Am J Respir Cell Mol 2011, 44(3):415-422. 718. Gutt R, Liauw SL, Weichselbaum RR. The role of radiotherapy in locally advanced pancreatic carcinoma. Nat Rev Gastroenterol Hepatol. 2010, 7(8):437-447. 719. Efimova EV, Mauceri HJ, Golden DW, Labay E, Bindokas VP, Darga TE, Chakraborty C, Barreto-Andrade JC, Crawley C, Sutton HG, Kron SJ, Weichselbaum RR. Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors. Cancer Res. 2010, 70(15):6277-6282. PMCID: PMC2912962. 720. Elas M, Hleihel D, Barth ED, Haney CR, Ahn KH, Pelizzari CA, Epel B, Weichselbaum RR, Halpern HJ. Where It's at Really Matters: In Situ In Vivo Vascular Endothelial Growth Factor Spatially Correlates with Electron Paramagnetic Resonance pO(2) Images in Tumors of Living Mice. Mol Imaging Biol. 2010 Oct 20. [Epub ahead of print]. 721. Kuo WL, Liu J, Mauceri H, Vokes EE, Weichselbaum R, Rosner MR, Cohen EE. Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context. Mol Cancer Ther. 2010; 9(10):2814-2824. PMCID: PMC2953602. 722. Burnette B, Liang H, Lee Y, Chlewicki L, Khodarev NN, Weichselbaum RR, Auh S, Fu YX. The Efficacy of Radiotherapy Relies Upon Induction of Type I Interferon-Dependent Innate and Adaptive Immunity. Cancer Res. 2011 71(7):2488-2496. 723. Mell LK, Jeong JH, Nichols MA, Polite BN, Weichselbaum RR, Chmura SJ. Predictors 82 of competing mortality in early breast cancer. Cancer. 2010 Dec 1;116(23):5365-5373. 724. Advani SJ, Markert JM, Sood RF, Gillespie GY, Shao MY, Roizman B, and Weichselbaum RR. Increased Therapeutic Efficacy of Oncolysis by Optimal Integration of Radiotherapy into the Replicative Cycle of HSV-1 for High Grade Gliomas. Gene Therapy, 2011 May 5. [Epub ahead of print]. 725. Barreto-Andrade JC, Efimova EV, Mauceri HJ, Beckett MA, Sutton HG, Darga TE, Vokes EE, Posner MC, Kron SJ and Weichselbaum RR. Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation. Mol Cancer Ther. 2011 Jul;10(7):1185-93. 726. Weichselbaum RR and Hellman S. Oligometastases revisited. Nat. Rev. Clin. Oncol, 2011 Jun;8(6):378-82. 727. Labay E, Efimova EV, Quarshie BK, Golden DW, Weichselbaum RR, Kron SJ, Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence. Int’l J High Throughput Screening, In Press, 2011. 728. Mathew B, Jacobson JR, Berdyshev E, Huang Y, Sun X, Zhao Y, Gerhold LM, Siegler J, Evenoski C, Wang T, Zhou T, Zaidi R, Moreno-Vinasco L, Bittman R, Chen CT, LaRiviere PJ, Sammani S, Lussier YA, Dudek SM, Natarajan V, Weichselbaum RR, and Garcia JGN. Role of sphingolipids in murine radiationinduced lung injury: protection by sphingosine 1-phosphate analogs. FASEB J, 2011 Oct;25(10):3388-400. Epub 2011 Jun 28. 729. Connell PP and Weichselbaum RR. A downside to apoptosis in cancer therapy? Nat Med. 2011, 17(7):780-782. 730. Wu TH, Schreiber K, Arina A, Khodarev NN, Efimova EV, Rowley DA, Weichselbaum RR, Schreiber H. Progression of cancer from indolent to aggressive despite antigen retention and increased expression of interferon-gamma inducible genes. Cancer Immun. 2011 Jun 30;11:2. 731. Murley JS, Baker KL, Miller RC, Darga TE, Weichselbaum RR, Grdina DJ. SOD2mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine. Free Radic Biol Med. 2011 Sep 3 (Epub ahead of Print) 732. Koshy M, Villano JL, Dolecek TA, Howard A, Mahmood U, Chmura SJ, Weichselbaum RR, McCarthy BJ. Improved survival time trends for glioblastoma using the SEER 17 population-based registries. J. Neurooncol. (Epub ahead of print) 733. Schmitt AM, Crawley CD, Kang S, Raleigh DR,Yu X, Wahlstrom JS, Voce DJ, Darga TE, Weichselbaum RR, Yamini B. p50 (NF-kB1) is an effector protein in the cytotoxic response toDNA methylation damage. Molecular Cell 2011 Dec 9;44(5):785-96 83 734. Soneru AP, Beckett MA, Weichselbaum RR, Lee RC. Mg ATP and antioxidants augment the radioprotective effect of surfactant copolymers. Health Phys. 2011 Dec;101(6):731-8. 735. Duarte CW, Wiley C, Zhi D, Cui X, Harris J, Vaughan LK, Mehta T, McCubrey R, Khodarev N, Weichselbaum RR, Gillespie GY. Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in Glioblastoma Multiforme in a subtypespecific manner. PLos ONE 2012;7(1):e29653. Epub 2012 Jan 5. 736. Lussier Y, Xing RH, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman SJ, Weichselbaum RR.MicroRNA Expression Characterizes Oligometastasis(es). PLoS ONE 2011 Dec 13,6(12):e28650 737. Mauceri HJ, Sutton HG, Darga TE, Kocherginsky M, Kochanski J, Weichselbaum RR, Vokes EE. Everolimus exhibits efficacy as a radiosensitizer in a model of non-small cell lung cancer. Oncology Reports 2012 May;27(5):1625-9.doi: 10.3892/or.2012.1666. Epub 2012 Jan 27. 738. Meng Y, Efimova EV, Hamzeh KW, Darga TE, Mauceri HJ, Fu Y-X, Kron SJ, Weichselbaum RR. Radiation-inducible Immunotherapy for Cancer: Senescent Tumor Cells as a Cancer Vaccine. Molecular Therapy 2012 Feb 14, Advance Online Publication 739. Ranck MC, Golden DW, Corbin KS, Hasselle MD, Liauw SL, Stadler WM, Hahn OM, Weichselbaum RR, Salama JK. Stereotactic Body Radiotherapy for the Treatment of Oligometastatic Renal Cell Carcinoma. American Journal of Clinical Oncology 2012 (In Press) 740. Schreiber K, Arina A, Engels B, Spiotto MT, Sidney J, Sette A, Karrison TG, Weichselbaum RR, Rowley DA, Schreiber H. Spleen Cells from young but not old immunized mice eradicate large established cancers. Clinical Cancer Research 2012 Mar 13 Epub ahead of print 84
