January 1992 (by PPCG;
amended January 2004)
Pasquale P. C. Graziadei
Born: July 13, 1921, Pavia, Italy
U.S. citizen (naturalized)
Education
M.D., University of Pavia (Italy) Medical School (1947)
Employment
1947–1952
Assistant Professor of Anatomy, Department of Anatomy, University of
Pavia Medical School
1952–1958 Associate Professor of Anatomy, Department of Anatomy, University
of Genoa Medical School
1958–1962 Professor of Anatomy, Department of Anatomy, University of Genoa
Medical School
1962–1966 Honorary Research Associate, Department of Anatomy, University
College London (England)
1966–1967 Visiting Associate Professor, Department of Biological Science, Florida
State University
1967–1976 Associate Professor, Department of Biological Science, Florida State
University
1976–[1996] Professor, Department of Biological Science, Florida State University
Fellowships
1958–1964
Visiting Scientist (summer months), Stazione Zoologica di Napoli
(Italy)
1962
1982
Alessandro Volta Award, University of Pavia (Italy)
The Stanley K. Freeman Award for "Innovative Research in the
Chemoreception Sciences," sponsored by International Flavors &
Fragrances.
Honors
Biographical listings
Who's Who in America (Marquis)
Who's Who in the South and Southwest (Marquis)
American Men and Women of Science
2
Societies
Society for Neuroscience
American Association of Anatomy
Association for Chemoreception Sciences (AChemS)
American Association for the Advancement of Science
International Brain Research Organization
Society for Developmental Neuroscience
Winter Conference on Brain Research
Scientific meetings
Cold Spring Harbor Symposium for Quantitative Biology (1965)
Society for Neuroscience Meeting (annually from 1970)
Association for Chemoreception Sciences (AChemS; annually from 1979)
American Association of Anatomy Meeting (annually from 1970)
International Symposium on Olfaction and Taste, Munich 1983, Snowmass
(Colorado) 1986
International Brain Research Organization, Regensburg (Germany) 1982, Budapest
(Hungary) 1987
Gordon Conference, 1970, 1983, 1989
International Society of Anatomy, Tokyo (Japan) 1975
Societá Italiana di Anatomia, Bari (Italy) 1980
Editorial boards
Journal of Neurocytology
Basic and Applied Histochemistry
Ad hoc reviews for
Journal of Comparative Neurology
American Journal of Anatomy
Brain Research
Tissue and Cell
The Anatomical Record
Journal of Neuroscience
Neuroscience
Cell and Tissue Research
Basic and Applied Histochemistry
Science
Nature
3
Invited lectures
Emory University Medical School, Department of Otolaryngology (1973)
CNRS, Laboratoire de Physiologie Nerveuse, Gif sur Yvette (1974)
Pavia University School of Medicine, Department of Physiology (1977)
University of Milano Medical School, Department of Histology and Embryology
(1977)
University of Miami Medical School, Department of Anatomy (1978)
National Science Foundation (1979)
New York University Medical Center, Department of Physiology and Biophysics
(1979, 1981)
University of Florida, Department of Neurobiology (1979, 1981)
Sechenov Institute of Evolutionary Physiology and Histochemistry, USSR Academy
of Sciences (1980)
Harvard University, Department of Neurobiology (1981)
University of Colorado Medical Center, Department of Structural Biology (1982)
Rockefeller University (1983)
Tulane University, Department of Biology (1983)
University of West Virginia, School of Medicine, Department of Anatomy (1983)
Yale University School of Medicine, Section of Neuroanatomy (1984)
Northwestern University, Department of Neurobiology and Physiology (1985)
Virginia Commonwealth University, Department of Physiology (1986, 1988)
University of Connecticut at Storrs, Department of Behavioral Neuroscience (1986)
Cajal Club, Cincinnati "Harman Memorial Lecture" (1988)
Max Plank Institut für Psychyatrie, Abteilung Neurochemie, Munich (1990, 1991)
Graduate students
Patricia Smith, M.Sc., 1969
Daniel Peteia, M.Sc., 1970
Roman Stanley, M.Sc., 1979
Leticia Alves, M.Sc., 1990
Rodney DeHan, Ph.D., 1971
Roger Bauerman, Ph.D., 1973
Joseph Metcalf, Ph.D., 1974
Dennis Emery, Ph.D., 1974
Peter Santi, Ph.D., 1975
Ron Stout, Ph.D., 1979
Ismail Fities, Ph.D., 1983
John Heckroth, Ph.D., 1986
Hyeyoung Kim, Ph.D., 1989
Laurence Dryer, Ph.D., 1993
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Research associates
Antonio Pierantoni (University of Genoa)
Richard Levine (University of New York)
David Samanen (University of Michigan
Michael Kaplan (Boston University)
Enrico Bignetti (University of Modena)
Tania Zigova (Slovak Academy of Sciences)
Mishba Eh Hawary (Assiut University, Egypt)
Sichuan Liu (Kuantong University, China)
Masumi Ichikawa (Tokyo University)
Shigeru Takami (Tokyo University)
Toshiya Osada (Tokyo University)
Roberto Assietti (Pavia University)
Lorenzo Magrassi (Pavia University)
Courses taught
Microscopic Anatomy of Vertebrates
Histology and Microanatomy
Neurocytology
Electron Microscope Techniques
Neurobiology for Graduate Students
Publications
Magrassi, L., and P. P. C. Graziadei. 1996. Lineage specification of olfactory neural
precursor cells depends on continuous cell interactions. Developmental Brain Research
96:11-27.
Morrison, E. E., and P. P. C. Graziadei. 1996. An ultrastructural study of glomeruli
associated with vomeronasal organs transplanted into the rat CNS. Anatomy and
Embryology 193:331-339.
Dryer, L., and P. P. C. Graziadei. 1996. Synaptology of the olfactory bulb of an
elasmobranch fish, Sphyrna tiburo. Anatomy and Embryology 193:101-114.
Ichikawa, M., T. Osada, and P. P. C. Graziadei. 1995. Coculture of the vomeronasal organ
and olfactory bulb of the fetal rat. Anatomy and Embryology 192:417-426.
Magrassi, L., and P. P. C. Graziadei. 1995. Cell-death in the olfactory epithelium. Anatomy
and Embryology 192:77-87.
Morrison, E. E., and P. P. C. Graziadei. 1995. Transplantation of postnatal vomeronasal
organ in the CNS of newborn rats. Anatomy and Embryology 191:319-327.
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Publications (continued)
Koo, H., and P. P. C. Graziadei. 1995. Eye primordium transplantation in Xenopus embryo.
Anatomy and Embryology 191:155-170.
Koo, H., and P. P. C. Graziadei. 1995. Cell-migration from the transplanted olfactory
placode in Xenopus. Anatomy and Embryology 191:171-181.
Dryer, L., and P. P. C. Graziadei. 1994. Projections of the olfactory bulb in an
elasmobranch fish, Sphyrna tiburo—segregation of inputs in the telencephalon. Anatomy
and Embryology 190:563-572.
Ichikawa, M., T. Osada, and P. P. C. Graziadei. 1994. Vicia villosa agglutinin inhibits the
fasciculation of vomeronasal axons in fetal rat vomeronasal organ culture. Brain Research
668:252-255.
Takami, S., C. A. Luer, and P. P. C. Graziadei. 1994. Microscopic structure of the olfactory
organ of the clearnose skate, Raja eglanteria. Anatomy and Embryology 190:211-230.
Dryer, L., and P. P. C. Graziadei. 1994. Influence of the olfactory organ on brain
development. Perspectives on Developmental Neurobiology 2:163-174.
Osada, T., K. Kito, K. Ookata, P. P. C. Graziadei, A. Ikai, and M. Ichikawa. 1994.
Monoclonal-antibody (vom2) specific for the luminal surface of the rat vomeronasal sensory
epithelium. Neuroscience Letters 170:47-50.
Dryer, L., and P. P. C. Graziadei. 1994. Mitral cell dendrites—a comparative approach.
Anatomy and Embryology 189:91-106.
Dryer, L., and P. P. C. Graziadei. 1993. A pilot-study on morphological
compartmentalization and heterogeneity in the elasmobranch olfactory bulb. Anatomy and
Embryology 188:41-51.
Graziadei, P. P. C. 1993. Olfactory organ culture in vivo and in vitro. Cytotechnology 11:36.
Takami, S., P. P. C. Graziadei, and M. Ichikawa. 1992. The differential staining patterns of
2 lectins in the accessory olfactory-bulb of the rat. Brain Research 598:337-342.
Takami, S., G. D. Fernandez, and P. P. C. Graziadei. 1992. The morphology of GABAimmunoreactive neurons in the accessory olfactory-bulb of rats. Brain Research 588:317323.
Zigova, T., P. P. C. Graziadei, and A. G. Monti-Graziadei. 1992. Olfactory-bulb
transplantation into the olfactory bulb of neonatal rats—a WGA HRP study. Brain Research
588:6-12.
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Publications (continued)
Bignetti, E., R. Ramoni, S. grolli, S. Pongolini, C. S. Wang, A. G. Monti-Graziadei, and P. P.
C. Graziadei. 1992. Immunological evidence for a novel marker protein in basal cells of
bovine nasal mucosa. Chemical Senses 17:169-178.
Monti-Graziadei, A. G., and P. P. C. Graziadei. 1992. Sensory reinnervation after partial
removal of the olfactory bulb. Journal of Comparative Neurology 316:32-44.
Graziadei, P. P. C., and A. G. Monti-Graziadei. 1992. The influence of the olfactory
placode on the development of the telencephalon in Xenopus laevis. Neuroscience 46:617629.
Takami, S., and P. P. C. Graziadei. 1991. Light microscopic golgi-study of mitral tufted
cells in the accessory olfactory bulb of the adult rat. Journal of Comparative Neurology
311:65-83.
Zigova, T., P. P. C. Graziadei, and A. G. M. Graziadei. 1991. Olfactory bulb transplantation
into the olfactory bulb of neonatal rats—an autoradiographic study. Brain Research 539:5158.
Takami, S., M. H. Elhawary, and P. P. C. Graziadei. 1990. Somatostatin-28-like
immunoreactivity in the rat olfactory bulb. Brain Research 526:333-337.
Zigova, T., P. P. C. Graziadei, and A. G. M. Graziadei. 1990. Olfactory-bulb transplantation
into the olfactory bulb of neonatal rats. Brain Research 513:315-319.
Takami, S., and P. P. C. Graziadei. Morphological complexity of the glomerulus in the rat
accessory olfactory-bulb—a golgi-study. Brain Research 510:339-342.
Graziadei, A. G. M., and P. P. C. Graziadei. 1989. Experimental studies on the olfactory
marker protein . 5. Olfactory marker protein in the olfactory neurons transplanted within the
olfactory-bulb. Brain Research 484:157-167.
Costanzo, R. M., and P. P. C. Graziadei. 1987. Development and plasticity. Pages 233-250
in Neurobiology of Taste and Smell, T. Finger and W. Silver, eds. John Wiley & Sons, New
York.
Morrison, E. E., P. P. C. Graziadei, and M. Costanzo. 1987. Degeneration-regeneration of
the olfactory neuroepithelium following bulbectomy—an SEM study. Annals of the New
York Academy of Sciences 510:512-514.
Graziadei, A. G. M., and E. E. Morrison. 1988. Experimental studies on the olfactory
marker protein. 4. Olfactory marker protein in the olfactory neurons transplanted within the
brain. Brain Research 455:401-406.
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Publications (continued)
Magrassi, L., and P. P. C. Graziadei. 1987. Single olfactory organ associated with
prosencephalic malformation and cyclopia in a Xenopus laevis tadpole. Brain Research
412:386-390.
Graziadei, P. P. C., and G. A. M. Graziadei. 1986. Principles of organization of the
vertebrate olfactory glomerulus—an hypothesis. Neuroscience 19:1025-1035.
Graziadei, P. P. C., and G. A. M. Graziadei. 1986. Neuronal changes in the forebrain of
mice following penetration by regenerating olfactory axons. Journal of Comparative
Neurology 247:344-356.
Graziadei, P. P. C., and G. A. M. Graziadei. 1985. Neurogenesis and plasticity of the
olfactory sensory neurons. Annals of the New York Academy of Sciences 457:127-142.
Magrassi, L., and P. P. C. Graziadei. 1985. Interaction of the transplanted olfactory placode
with the optic stalk and the diencephalon in Xenopus laevis embryos. Neuroscience 15:903- .
Butler, A. B., P. P. C. Graziadei, G. A. M. Graziadei, and B. M. Slotnick. 1984. Neonatally
bulbectomized rats with new olfactory-neocortical connections are anosmic. Neuroscience
Letters 48:247-254.
Monti-Graziadei, G. A., and P. P. C. Graziadei. 1984. The olfactory organ, neural
transplantation. Pages 167-186 in Neurological Transplants, J. R. Sladek and D. M. Gash,
eds. Plenum Press, New York.
Morrison, E. E., and P. P. C. Graziadei. 1983. Transplants of olfactory mucosa in the rat
brain. 1. A light microscopic study of transplant organization. Brain Research 279:241-245.
Graziadei, P. P. C., and A. G. M. Graziadei. 1983. Regeneration in the olfactory system of
vertebrates. American Journal of Otolaryngology 4:228-233.
Klein, S. L., and P. P. C. Graziadei. 1983. The differentiation of the olfactory placode in
Xenopus laevis—a light and electron-microscope study. Journal of Comparative Neurology
217:17-30.
Costanzo, R. M., and P. P. C. Graziadei. A quantitative analysis of changes in the olfactory
epithelium following bulbectomy in hamster. Journal of Comparative Neurology 215:370381.
Miragall, F., and G. A. M. Graziadei. 1982. Experimental studies on the olfactory marker
protein .2. appearance of the olfactory marker protein during differentiation of the olfactory
sensory neurons of mouse—an immunohistochemical and autoradiographic study. Brain
Research 239:245-250.
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Publications (continued)
Graziadei, G. A. M., and P. P. C. Graziadei. 1981. Experimental studies on the olfactory
marker protein. 1. Presence of the olfactory marker protein in tufted and mitral cells. Brain
Research 209:405-410.
Stout, R. P., and P. P. C. Graziadei. 1980. Influence of the olfactory placode on the
development of the brain in Xenopus laevis (Daudin). 1. Axonal growth and connections of
the transplanted olfactory placode. Neuroscience 5:2175-2186.
Graziadei, P. P. C., and M. S. Kaplan. 1980. Regrowth of olfactory sensory axons into
transplanted neural tissue. 1. Development of connections with the occipital cortex. Brain
Research 201:39-44.
Monti-Graziadei, G. A., R. S. Stanley, and P. P. C. Graziadei. 1980. The olfactory marker
protein in the olfactory system of the mouse during development. Neuroscience 5:12391252.
Graziadei, P. P. C., and G. A. Monti-Graziadei. 1980. Neurogenesis and neuron
regeneration in the olfactory system of mammals. 3. Deafferentation and re-innervation of
the olfactory bulb following section of the fila olfactoria in rat. Journal of Neurocytology
9:145-162.
Monti-Graziadei, G. A., M. S. Karlan, J. J. Bernstein, and P. P. C. Graziadei. 1980. Reinnervation of the olfactory bulb after section of the olfactory nerve in monkey (Saimiri
sciureus). Brain Research 189:343-354.
Graziadei, P. P. C., and D. W. Samanen. 1980. Ectopic glomerular structures in the
olfactory bulb of neonatal and adult mice. Brain Research 187:467-472.
Graziadei, P. P. C., M. S. Karlan, G. A. Monti-Graziadei, and J. J. Bernstein. 1980.
Neurogenesis of sensory neurons in the primate olfactory system after section of the fila
olfactoria. Brain Research 186:289-300.
Graziadei, P. P. C., R. R. Levine, and G. A. Monti-Graziadei. 1979. Plasticity of
connections of the olfactory sensory neuron—regeneration into the forebrain following
bulbectomy in the neonatal mouse. Neuroscience 4:713-727.
Graziadei, G. A. M., and P. P. C. Graziadei. 1979. Neurogenesis and neuron regeneration in
the olfactory system of mammals. 2. Degeneration and reconstitution of the olfactory
sensory neurons after axotomy. Journal of Neurocytology 8:197-213.
Graziadei, P. P. C., M. Okano. 1979. Neuronal degeneration and regeneration in the
olfactory epithelium of pigeon following transection of the 1st cranial nerve. Acta
Anatomica 104:220-236.
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Publications (continued)
Graziadei, P. P. C., and G. A. Monti-Graziadei. 1979. Neurogenesis and neuron
regeneration in the olfactory system of mammals. 1. Morphological aspects of
differentiation and structural organization of the olfactory sensory neurons. Journal of
Neurocytology 8:1-18.
Monti-Graziadei, G. A., and P. P. C. Graziadei. 1979. Studies on neuronal plasticity and
regeneration in the olfctory system: morphologic and functional characteristics of the
olfactory sensory neuron. Pages 373-396 in Neural Growth and Differentiation, E. Maisami
and M. A. B. Brazier, eds. Raven Press, New York.
Graziadei, P. P. C., R. R. Levine, G. A. Monti-Graziadei. 1978. Regeneration of olfactory
axons and synapse formation in forebrain after bulbectomy in neonatal mice. Proceedings of
the National Academy of Sciences of the USA 75:5230-5234.
Graziadei, P. P. C., and G. A. M. Graziadei. 1978. Observations on ultrastructure of
ganglion cells in circumvallate papilla of rat and mouse. Acta Anatomica 100:289-305.
Graziadei, P. P. C., and G. A. Monti-Graziadei. 1978. Continuous nerve cell renewal in the
olfactory system. Pages 55-83 in Handbook of Sensory Physiology, Vol. IX, M. Jacobson,
ed. Springer-Verlag, Berlin.
Graziadei, P. P. C., and G. A. Monti-Graziadei. 1978. The olfactory sensory system: a
model for the study of neurogenesis and axon regneration in mammals. Pages 131-153 in
Neuronal Plasticity, C. W. Cotman, ed. Raven Press, New York.
Graziadei, P. P. C. 1977. Funcational anatomy of the mammalian chemoreceptor system.
Pages 435-454 in Chemical Signals in Vertebrates, D. Muller-Schwarze and M. M. Mozell,
eds. Plenum Press, New York.
Graziadei, G. A. M., F. L. Margolis, J. W. Harding, and P. P. C. Graziadei. 1977.
Immunocytochemistry of olfactory marker protein. Journal of Histochemistry &
Cytochemistry 25:1311-1316.
Harding, J., P. P. C. Graziadei, G. A. Monti-Graziadei, and F. L. Margolis. 1977.
Denervation in primary olfactory pathway of mice. 4. Biochemical and morphological
evidence for neuronal replacement following nerve-section. Brain Research 132:11-28.
Graziadei, P. P. C., and H. T. Gagne. 1976. Sensory innervation in rim of octopus sucker.
Journal of Morphology 150:639-679.
Graziadei, P. P. C., and H. T. Gagne. 1976. Unusual receptor in octopus. Tissue & Cell
8:229-240.
10
Publications (continued)
Graziadei, P. P. C., and G. A. Monti-Graziadei. 1976. Olfactory epithelium of Necturus
maculosus and Ambystoma tigrinum. Journal of Neurocytology 5:11-32.
Santi, P. A., and P. P. C. Graziadei. 1975. Light and electron-microscope study of intraepithelial putative mechanoreceptors in squid suckers. Tissue & Cell 7:689-702.
Oley, N., R. S. Dehan, D. Tucker, J. C. Smith, and P. P. C. Graziadei. 1975. Recovery of
structure and function following transection of primary olfactory nerves in pigeons. Journal
of Comparative and Physiological Psychology 88:477-495.
Graziadei, P. P., and R. S. Dehan. 1973. Neuronal regeneration in frog olfactory system.
Journal of Cell Biology 59:525-530.
Dehan, R. S., and P. P. C. Graziadei. 1973. Innervation of frogs taste organ—a
histochemical study. Life Sciences 13:1435-1449.
Graziadei, P. P., and H. T. Gagne. 1973. Extrinsic innervation of olfactory epithelium.
Zeitschrift fur Zellforschung und Mikroskopische Anatomie 138:315-326.
Graziadei, P. P. 1973. Cell dynamics in olfactory mucosa. Tissue & Cell 5:113-131.
Graziadei, P. P. C. 1973. The ultrastructure of vertebrate olfactory mucosa. Pages 269-305
in The Ultrastructure of Sensory Organs, I. Friedmann, ed. North-Holland, Amsterdam,
London.