Mayumi Fujita, M.D., Ph.D.
Associate Professor
Department of Dermatology
Phone: (303) 724-4045 (office), 303-724-4037 or 303-724-4046 (lab)
Fax: (303) 724-4048
E-Mail: mayumi.fujita@ucdenver.edu
EDUCATION/TRAINING
Institution and location
Degree
Field of study
Kyoto University Faculty of Medicine, Japan
Kyoto University Faculty of Medicine, Japan
Kyoto University Faculty of Medicine, Japan
Kyoto University Faculty of Medicine, Japan
University of Colorado, Denver, CO
University of Washington, Seattle, WA
University of Washington, Seattle, WA
University of Washington, Seattle, WA
M.D.
Internship
Residency
Ph.D.
Fellowship
Fellowship
Internship
Residency
Medicine
Medicine/Dermatology
Dermatology
Immunology
Tumor biology
Skin biology
Internal Medicine
Dermatology
EMPLOYMENT
1986 - 1990
1990 - 1992
1992 - 1996
2002 - 2008
Instructor in Dermatology, Kyoto University FOM, Kyoto, Japan
Medical Staff in Dermatology, Tenri Hospital, Nara, Japan
Assistant Professor of Dermatology, Kyoto University FOM, Kyoto, Japan
Assistant Professor of Dermatology, University of Colorado HSC, Aurora,
CO
2002 - present Director of Psoriasis Clinic, University of Colorado Hospital, Aurora, CO
2008 - present Associate Professor of Dermatology, University of Colorado Denver,
Aurora, CO
2010- present Dermatology physician, Department of Veterans Affairs Hospital, Denver,
CO
HONORS
Sasagawa Research Award (1992-3, 1993-4), Dermatology Foundation Fellowship (1993-4,
1994-5), Women’s Dermatologic Society Mentorship award (2001), NIH Fellowship (5
T32 AR07019-25) (2001-2), AAD (American Association of Dermatology) Travel Award
to European Dermatology Society Meeting (2001), NIH Award for NIH Dermatology
Branch Resident Visit Day (2001), World Congress Education Fund Task Force
Scholarship Award for International Investigative Dermatology 2003 (2003)
INVENTIONS AND PATENTS
WO/2008/069881 (International Application No. PCT/US2007/023386)
US2010/0248225 A1 (U.S. Patent Application No. 12/312,390)
WO/2009/085695 (International Application No. PCT/US2008/086830)
US20090169497 (U.S. Patent Application No. 12/335,110)
CLINICAL INTERESTS
Psoriasis, auto-immune disease, melanoma
RESEARCH INTERESTS
Melanoma biology, melanoma immunology, skin immunology, disease biomarker
OVERVIEW OF ONGOING RESEARCH
The main focus of our current research is: (1) to study biological roles of several
inflammatory molecules (particularly IL-1, IL-37 and AAT) in the progression of human
malignant melanoma, (2) to analyze inflammasome components in human melanoma cells,
(3) to identify melanoma-related and host response-related biomarker profiling from blood
of melanoma patients, (4) to identify and characterize melanoma stem cells from human
melanoma cells and (5) to study biological roles of several inflammatory molecules in skin
immunology. The experiments utilize in vitro methodologies (cellular and molecular
biology, immunology, pathology) and in vivo animal study (xenotransplantation, direct in
vivo xenograft and genetically-engineered mouse models).
SELECTED PUBLICATIONS (15 most recent papers out of 51 peer-reviewed ones)
1.
Y Luo, S Robinson, J Fujita, L Siconolfi, J Magidson, CK Edwards, K Wassman,
K Strom, DA Norris, D Bankaitis-Davis, WA Robinson, M Fujita: Transcriptome
profiling of whole blood cells identifies PLEK2 and C1QB in human melanoma.
Accepted for publication in PLoS ONE
2. R Prado, James D Jensen, M Okamoto, Y Luo, KD Lewis, M Fujita: Metastatic
melanoma manifesting with purulent nodules composed of neutrophils and
melanoma cells. Accepted for publication in European Journal of Dermatology
3. A Tanaka, James D Jensen, Renata Prado, H Riemann, YG Shellman, DA Norris, L
Chin, C Yee, M Fujita: Whole recombinant yeast vaccine induces anti-tumor
immunity and improves survival in a genetically engineered mouse model of
melanoma. Gene Therapy 18, 2011 (in press).
4. A Anwar, DA Norris, M Fujita: Ubiquitin proteasomal pathway mediated
degradation of p53 in melanoma. Arch Biochem Biophys 508:198-203, 2011
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James D Jensen, Mayumi Fujita, and Robert P. Dellavalle. Validation of Psoriasis
Clinical Severity and Outcome Measures: Searching for a Gold Standard. Arch
Dermatol 147:95-98, 2011
R Prado, S Brice, S Fukuda, T Hashimoto, M Fujita: Paraneoplastic pemphigus
herpetiformis with IgG antibodies to desmoglein 3 and without mucosal lesions.
Arch Dermatol 147:67-71, 2011
X. Wang, M. Fujita (corresponding author), R. Prado, A. Tousson, H-C. Hsu, A.
Schottelius, D.R. Kelly, P.A. Yang, Q. Wu, J. Chen, H. Xu, C.A. Elmets, J.D.
Mountz, C.K.III Edwards: Visualizing CD4 T cell migration into inflamed skin and
its inhibition by CCR4/CCR10 blockades using in vivo imaging model. Br J
Dermatol 162: 487-96, 2010
J Strahan, JA Chorny, JL Cohen, M Fujita: Combined multifocal indeterminate
cell histiocytosis and basal cell carcinoma. Arch Dermatol 146:346-7, 2010
M Okamoto, W Liu, Y Luo, A Tanaka, X Cai, DA Norris, CA Dinarello, M Fujita:
Constitutively active inflammasome in human melanoma cells mediating
autoinflammation via caspase-1 processing and secretion of interleukin-1 J Biol
Chem 285: 6477-88, 2010
J Strahan, M Fujita: Violaceous nodule on the knee. Arch Dermatol 145:715-720,
2009
LA Miller, NB Goldstein, WU Johannes, C Walton, M Fujita, DA Norris, YG
Shellman: BH3 mimetic ABT-737 synergistically kills melanoma cells with a
proteasome inhibitor. J Invest Dermatol 129: 964-971, 2009
NB Goldstein, WU Johannes, AV Fadeliya, M Green, M Fujita, DA Norris, YG
Shellman: Active Nras and Braf inhibit anoikis by downregulating Bim expression
in melanoma cells. J Invest Dermatol 129: 432-437, 2009
M Fujita, W High, S Asgari, C Lewis, R Gonzalez: Development of vitiligo during
melanoma treatment with a novel survivin inhibitor: a case report and review of the
literature. Int J of Dermatol 48: 426-430, 2009
ML Usui, JN Mansbridge, WG Carter, M Fujita, JE Olerud: Keratinocyte
migration, proliferation and differentiation in chronic ulcers from patients with
diabetes and normal wounds. J Histochem Cytochem 56:687-696, 2008
A Anwar, GU Mallikarjuna, S Brady, L Qamar, K Behbakht, YG Shellman, R
Agarwal, DA Norris, L Horwitz, M Fujita: Photoprotective effects of bucillamine
against UV-induced damage in a SKH-1 hairless mouse model. Photochemistry
and Photobiology 84:477-483, 2008
OTHER PUBLICATIONS (non peer-reviewed)
9
proceedings (non peer-reviewed)
4
invited review articles (non peer-reviewed)
67 meeting abstracts published in journals
76 clinical/research papers in Japanese medical journals (in Japanese)
30 medical essays in Japanese Journal of Clinical Dermatology (in Japanese)