Basin-scale Hydrogeology and Paleohydrology: The movement of deep groundwaters and hot brines through the Earth’s crust plays a major role in many geologic processes including hydrothermal ore deposits, petroleum migration and entrapment, geothermal anomalies, and diagenesis of sediments. During the last decade, it has become possible to quantify these processes using sophisticated numerical models that quantify groundwater flow, heat transport and reactive solute transport within heterogeneous, anisotropic and deforming sedimentary basins. These processes were studied at the Dead Sea Rift. This continental rift is located at the deepest continental depression on Earth; it is young and tectonically active, and extreme climate changes, water-level oscillations, and salinity fluctuations have occurred. Therefore, it serves as a unique and exciting global site to study geofluid processes. Studies were concentrated at two locations: the fresh Sea of Galilee and the hyper-saline Dead Sea. Through these studies, several ambiguous field observations, which caused fundamental debates among the scientific community during the last few decades, were clarified. The hydrodynamics of groundwater surrounding the Sea of Galilee were analyzed using a two-dimensional finite element code that solves the coupled variable-density groundwater flow and heat transfer equations. The surprising opposite salinity-discharge relationships observed at the lake saline-hot springs, and the ambiguous geothermal anomalies detected in the vicinity of the lake were explained: 1. Gvirtzman, H., Garven, G. and Gvirtzman, G., 1997. Hydrogeological modeling of the saline hot springs at the Sea of Galilee, Israel, Water Resources Research, 33: 913-926. 2. Gvirtzman, H., Garven, G. and Gvirtzman, G., 1997. Thermal anomalies associated with forced and free convective groundwater systems at the Dead-Sea Rift Valley, Geological Society of America Bulletin, 109: 1167-1176. 3. Hurwitz, S., Goldman, M., Ezersky, M. and Gvirtzman, H., 1999. Geophysical (TDEM) delineation of a shallow brine beneath a fresh-water lake, the Sea of Galilee, Israel, Water Resources Research, 35: 3631-3638. 4. Hurwitz, S, Lyakhovsky, V. and Gvirtzman, H., 2000. Transient salt transport modeling of a shallow brine beneath a fresh water lake, the Sea of Galilee, Water Resources Research, 36: 101-107. 5. Hurwitz, S., Stanislavsky, E., Lyakhovsky, V. and Gvirtzman, H., 2000. Transiet groundwater-lake interactions in a continental rift: Sea of Galilee, Israel, Geological Society of America Bulletin, 112: 1694-1702. Although the geochemical evolution of the typical brine of Dead Sea Rift is well understood, its sub-surface migration dynamics have never been explained. Using numerical modeling that solves the coupled groundwater flow and heat and solute transport equations within a deforming geologic structure, the paleohydrological system in the Dead Sea vicinity became clearer. It has been proposed and quantified the coexistence of a large-scale westward density-driven groundwater flow system in deep aquifers and eastward gravitydriven groundwater flow system in shallow aquifers. Consequently, we explained the interrelationships between brine and hydrocarbon migrations and the entrapment of the gas in several geologic structures at the southwest side of the Dead sea were explained; thereby solving a 20-years-long debate regarding their evolution. Stanislavsky, E. and Gvirtzman, H., 1999. Basin-scale migration of continental-rift brines: Paleohydrologic modeling of the Dead Sea basin, Geology, 27: 791-794. Gvirtzman, H. and Stanislavsky, E., 2000b. Large-scale flow of geofluids at the Dead Sea Rift, Journal of Geochemical Exploration, 69-79: 207-211. Gvirtzman, H. and Stanislavsky, E., 2000a. Paleohydrology of hydrocarbon maturation, migration and accumulation at the Dead Sea Rift, Basin Research, 12: 79-93.