Subject 29 - Chronic pancreatitis (3 hours) Place Training Room, department of gastroenterology, ultrasound room . Purpose To know: • Identify the major forms of chronic pancreatitis. • The value of the major etiological factors that lead to the emergence of this disease. • International and Marseille -Roman classification of chronic pancreatitis. • Features of the clinical course of the main forms of chronic pancreatitis , laboratory and instrumental diagnosis and differential diagnosis , depending on the shape and location of the pathological process. • Major complications : infectious and noninfectious • Laboratory and instrumental methods in the diagnosis of various forms of chronic pancreatitis. • The differential diagnosis of chronic pancreatitis from peptic ulcer , chronic cholecystitis, pancreatic cancer • Principles of differential treatment of different forms of chronic pancreatitis using dietary methods and drugs and non-drug treatments. • Fixed primary and secondary prevention . • Weather and performance depending on the degree and form of the pathological process. Be able to: • Conduct a survey and physical examination of patients with chronic pancreatitis • justify the use of the basic diagnostic methods for diagnosis of chronic pancreatitis determine the indications and contraindications for their conduct • Identify the typical clinical picture of various forms of chronic pancreatitis • Identify key variants of the course and complications of chronic pancreatitis • to the differential diagnosis of various forms and degree course pancreatitis and formulate clinical diagnosis in ICD-10 • develop a plan of inspection of patient with chronic pancreatitis • appoint the treatment of various forms of chronic pancreatitis using dietary methods, drugs and non-drug treatments • conduct primary and secondary prevention of various forms of chronic pancreatitis Professional orientation of students Chronic pancreatitis have a greater prevalence of knowledge necessary for early detection and differential diagnosis with other gastroenterological diseases. The need for right use of modern methods of clinical , laboratory and instrumental examination for the purpose of timely diagnosis and adequate treatment , thus preserving the performance of patients and prevent complications. Basic knowledge and skills № 1. Discipline Anatomy 2, Physiology 3. Biochemistry to know Anatomical structure of the pancreas Physiology of the pancreas . The role of enzymes in the digestive process Composition of pancreatic juice To be able 4. Pathophysiology 5. Propedevtika internal diseases Mechanisms violations formation and excretion of pancreatic juice Semiotics of disorders of the pancreas to evaluate clinical and laboratory studies Plan for practical lesson № Elements of practical employments Time(minutes) 1. Verification of present's students 5 2. Entrance control and his analysis 15 patients for Supervision ( card or clinical tasks ) 3. Distributing * 5 patients or study of educational hospital chart 4. Review * 30 5. Discussion of findings, formulation of previous diagnosis, determination of methods of additional inspection of patient, interpretation of their results, formulation of final diagnosis and plan of treatment 30 6. Exercises with clinical formulations for solving clinical situation tasks 15 7. Output control of knowledge and its evaluation 15 8. Results and final assessment of knowledge and skills of students and tasks to self- preparation for the next lesson 5 Note: * - in the case of patients absence in clinical, practice can be made in the form of preparation and decision of situational tasks. List of theoretical issues addressed in class 1. Definition of chronic pancreatitis. 2. The value of different etiological factors. 3. Classification (ICD- 10). 4. Features of the clinical course of various clinical forms , diagnosis and differential diagnosis , depending on the shape and location of the pathological process. 5. Complications: infectious and noninfectious . 6. Methods of clinical , laboratory, research tool in the diagnosis of pancreatitis. 7. Differential treatment of various forms of chronic pancreatitis. 8. Primary and secondary prevention . 9. Weather and performance Methods of practical classes (* The first lesson the teacher carries out safety training (if any condition) , which is celebrated in the magazine signed by student teacher ). After reviewing the present teacher carries out a written entrance control basic knowledge . Then the instructor carries out the distribution of students for Supervision of patients and determine their problem. № Task Instructions a student Note: teacher for students 1. To provide curation of patient with chronic pancreatitis In the survey reveal : 1. Signs violation of exocrine pancreatic function 2. Characteristic clinical manifestations of chronic pancreatitis , changes in laboratory parameters, changes in pancreatic ultrasound , x-ray changes , endoscopic retrograde changes during холецистохолангіопанкреатографії ( ERCP) 3. The degree of chronic pancreatitis Pay particular attention to the identification of possible etiologic factors. Motivate different levels course of chronic pancreatitis Teachers work according to the plan of studies, spend the weekend at the end of the control knowledge. Before the end of class the teacher sums up the results of his studies on the assessment of each student and announce the topic of the next session. Visual material 1. VCR , overhead projector . 2. Tables and slides 3. Educational history. 4. DVD drive with Ultrasound examination of the pancreas 5. A set of situational tasks and test tasks. Forms and methods of selfTests 1. By enzyme preparations should include : A. Alohol . B. Magnesium sulfate . C. Pancreatin . D. Sodium salicylate . E. Nifuroksazyd . 2. Chronic pancreatitis in a patient's blood high : A. bilirubin B. ALT . C. Amylase . D. Timolovoyi sample. E. Cholesterol . 3. By the Marseille - Rome classification include A. Chronic calcificational pancreatitis. B. Island pancreatitis. C. Recurrent pancreatitis. D. Chronic pancreatitis. E. Chronic pancreatitis latency . Situational tasks 1. Sick '47 complains of pain in the left upper quadrant, epigastrium after taking fatty foods and alcohol, meteorism , weakness. Ob-no : Abdomen sensitive to palpation in both upper quadrant, epigastrium. In biochemical analysis of blood (liver complex) revealed increasing levels of amylase twice. With ultrasound liver not enlarged, granular structure , not enlarged gallbladder , pancreas enlarged, heterogeneous structure , granular, ehohenist increased. What is the most likely diagnosis ? What do I need to clarify the etiology of the process? Assign the required treatment . 2. The patient is 52 years old. Complains of intense pain in the upper abdomen radiating to the left , anorexia, nausea, zakrepyy . Seizures are up to 2-3 times a year. Three years ago cholecystectomy. After half a year after the operation was again an attack of severe pain . Appeared mild jaundice, increased levels of urinary diastase . Ultrasound, ERCP and stones in the ducts not found. OBJECTIVE: subikterychnist sclera. Pain at the points Desjardins , Gubergrits , Mayo -Robson. Blood analysis without pathological changes. The aggravation of the disease which occurs ? Assign the required treatment . Sources of information Basic: Therapy. Course of lectures. Simferopol. -2003.- 444p. Additional: 1. Harrison's Principles of Internal Medicine 18th edition. .org) Individual Students Program topics Explore : • Chronic pancreatitis : etiology , options disturbances in the formation of pancreatitis. • Principles of treatment of chronic pancreatitis: dietary , medical and nemedikamentozne treatment. • Significance of the infection, nutritional factors and chronic diseases of the gastrointestinal tract in the development of chronic pancreatitis. • Clinical course and extent of chronic pancreatitis, clinical features of different forms of pancreatitis. • The role of laboratory and instrumental methods of diagnosis and differential diagnosis of chronic pancreatitis.