GOELDNER, Maurice, Philippe
Address
Laboratoire de Chimie Bio-organique - UMR 7175 LC1 CNRS
Faculté de Pharmacie - Université Louis Pasteur Strasbourg
B.P. 24 - 67401 Illkirch Cédex
Tél: 03 90 24 41 62 - FAX 03 90 24 43 06 e-mail: goeldner@bioorga.u-strasbg.fr
1967 Licence-ès-Sciences Physiques Université Louis Pasteur Strasbourg
1969
Thèse de 3ème Cycle - Université Louis Pasteur Strasbourg
1972
Thèse de Doctorat d'Etat - Université Louis Pasteur Strasbourg
1983
Agrégation en Pharmacie (Option - Chimie Organique)
Janv. 1971 CNRS researcher - Attaché de recherches
1972 PhD Thesis Director Dr. J-F Biellmann
1972 1973 Post-doc Prof. S. Wolfe; Queen's University, Kingston Canada
1974 -1975 Post doc : Prof. A. Eschenmoser E.T.H. Zürich – Switzerland
Oct.1983
Professeur in Organic Chemistry Faculté de Pharmacie Strasbourg
1987 - 1988 Sabbatical Prof. J.E. Casida - UC Berkeley - USA
Current professional Position
Professor of Organic Chemistry Pharmacy Faculty
Head of a new teaching program : Master Chimie & Biologie
Head of the Laboratoire de Chimie Bioorganique CNRS UMR 7175-LC1
Prize of the Academy of Sciences Grammatikakis-Neumann together with C. Hirth
1

Bioorganic Chemistry, Caged compounds, Photoaffinity Labeling, Fluorescent probes,
Time-resolved studies, Membrane receptors, Engineered affinity labeling of receptors
About 80 CONFERENCES as invited speaker
105.
B. Foucaud, Ph. Perret, T. Grutter and M. Goeldner*
Cysteine mutants as chemical sensors for ligand-receptor interactions
(2001) Trends in Pharmacol. Sci. 23, 170-173.
106.
T. Bunyapaiboonsri, O. Ramström, S. Lohmann, J-M. Lehn*, L.Peng and M. Goeldner
Dynamic deconvolution of a pre-equilibrated dynamic combinatorial library of acetylcholinesterase inhibitors
(2001) ChemBioChem. 2, 438-444.
107.
A Specht, Th. Ursby, M. Weik, L. Peng, J. Kroon, D. Bourgeois* and M. Goeldner*
Cryophotolysis of ortho -nitrobenzyl derivatives of enzyme ligands for the potential kinetic crystallographic of macromolecules. (2001) ChemBioChem 2, 845-848.
108.
S. Loudwig and M. Goeldner*
N -MethylN -[ o -nitrophenyl]carbamates as photochemically removable alcohol protecting groups
(2001) Tetrahedron Lett. 42, 7957-7959.
109.
S. Loudwig, A. Specht et M. Goeldner*
Les composés cagés ou les précurseurs photochimiques de molécules biologiquement actives : Mise au point et perspectives. (2002) Actualités Chimiques Janvier pp7-12.
110.
P. Perret, B. Laube, R. Schemm, H. Betz, M. Goeldner and B. Foucaud*
Affinity labeling of cysteine mutants highlights contact residues in modelled receptor binding-sites.
(2002) J. Receptor & Signal Transduction Research. 22, 345-356.
111 . T. Ursby, M. Weik, E. Fioravanti, M. Delarue, M. Goeldner & D. Bourgeois*
Cryophotolysis of caged compounds : A technique for trapping intermediate states in protein crystals
(2002) Cryst. Acta D 58, 607-614.
112. T. Grutter*, S. Bertrand, F. Kotzyba-Hibert, D. Bertrand and M. Goeldner
Structural reorganization of the acetylcholine binding site of Torpedo nicotinic receptor as revealed by dynamic photoaffinity labeling. (2002) ChemBioChem. 3, 652-658.
113. A. Mourot, F. Kotzyba-Hibert, E. Doris and M. Goeldner
Modified and improved synthesis of a tritiated photoactivatable nicotinic agonist [
(2002) J. labelled Compd. Radiopharm. 45, 8947-8950.
3 H]-AC
5
.
2

114.
A. Specht, P. Bernard, M. Goeldner* and L. Peng*
Mutually induced formation of host-guest complexes between p -sulfonated calix[8]arene and cholinergic ligands
(2002) Angew. Chem. Int. Ed.. 41, 4706-4708.
115.
A. Specht , S. Loudwig, L. Peng and M. Goeldner* p -Hydroxyphenacyl bromide as photoreversible thiol label : A potential phototrigger for thiol-containing biomolecules (2002) Tetrahedron Lett. 43, 8947-8950.
116.
C. Che, G. Petit, F. Kotzyba-Hibert, S. Bertrand, D. Bertrand, T. Grutter and
M. Goeldner*
Synthesis and biological properties of cysteine-reactive epibatidine derivatives
(2003) Bioorg. Med. Chem. Lett. 13, 1001-1004.
117.
B. Foucaud*, B. Laube, R. Schemme, A. Kreimeyer, M. Goeldner and H. Betz
Structural model of the NMDA-receptor glycine site probed by site-directed chemical coupling
(2003) J. Biol. Chem. 278, 24011-24017.
118. S. Loudwig, Y. Nicolet, P. Masson, J. Fontecilla-Camps, S. Bon, F. Nachon and M. Goeldner*
Photoreversible inhibition of cholinesterases : Catalytic serine-labeled caged butyrylcholinesterase
(2003) ChemBio Chem 4, 762-767.
119.
D. Berezhnoy, A. Gonthier, H. Schwob, M. Goeldner, E. Sigel*
On the benzodiazepine binding pocket in GABA
A
receptors (2004) J. Biol. Chem. 279, 3160-3168.
120 .
A. Specht M. Goeldner*
 o -Nitrophenyl  trifluoroethyl- ether derivatives as stable and efficient photoremovable alcohol protecting groups : potential use for the caging of alcohol-containing biomolecules.
(2004) Angew. Chem. Int. Ed. Engl., 43, 2008-2012.
121.
C. Che, T. Grutter, A. Mourot, F.Hibert and M. Goeldner*
Site-directed reactive probes for structural and functional investigation of cholinergic proteins 2004, in “Proc.
XIth Cholinergic Mechanisms Symposium”, pp 39-44 A. Fisher and H. Soreq Eds., Martin Dunitz Ltd, London.
122.
F. Kotzyba-Hibert*, A. Mourot, T. Grutter, M. Goeldner
Mapping the Acetylcholine Binding Sites of Torpedo Nicotinic Receptor using Photoaffinity Labeling : past, present and future. (2004) in « XIth Cholinergic Mechanisms Symposium”pp 44-47 , A. Fisher and H. Soreq
Eds., Martin Dunitz Ltd, London.
123 . S. Loudwig, A. Specht and M. Goeldner*:
"Photoreversible inhibition of cholinesterases" (2004) in "Cholinesterases in the second millenium: biomolecular and pathological aspects" pp 277-283, N.C. Inestrosa & E.O. Campos Eds. MIFAB Chile.
124.
M. Goeldner
Caging of ATP and Glutamate : A comparative analysis (2005) in « Dynamic studies in Biology : Phototriggers, photoswitches and caged biomolecules » pp 76-94, M Goeldner & R. Givens Eds, Wiley -VCH
125.
L. Peng and M. Goeldner
3

Photoregulation of proteins : Caged enzyme modulators.(2005) in « Dynamic studies in Biology : Phototriggers, photoswitches and caged biomolecules » pp 303-324, M. Goeldner & R. Givens Eds, Wiley VCH .
126.
M. Goeldner, R. Givens
Foreword (2005) in « Dynamic studies in Biology : Phototriggers, photoswitches and caged biomolecules » pp
M Goeldner, R. Givens Eds, Wiley VCH
127 . D. Berezhnoy, R. Baur, A. Gonthier, B. Foucaud, M. Goeldner, E. Sigel*
Conformational changes at benzodiazepine binding sites of GABA
(2005) J. Neurochem. 92, 859-866.
128 A. Specht, F. Ziarelli, Ph. Bernard, M. Goeldner L. Peng*
A
receptors detected with a novel technique para -Sulfonated calixarenes used as synthetic receptors for complexing photolabile cholinergic ligands
(2005) Helv. Chim. Acta 88, 2641-2653.
129 A Mourot*, J. Rodrigo, F. Kotzyba-Hibert, S. Bertrand, D. Bertrand, M. Goeldner
Probing the reorganization of the nAChR during desensitization by time-resolved covalent labeling using [ 3 H]
AC
5
, a photoactivatable agonist. (2006) Mol. Pharmacol. 69, 452-461.
130.
A. Mourot*, Th. Grutter, M. Goeldner and F. Kotzyba-Hibert
Dynamic structural investigation on the Torpedo nicotinic acetylcholine receptor using time-resolved photoaffinity labeling. (2006) ChemBioChem 7, 570-583.
131.
A. Specht , J-S. Thomann, K. Alarcon, W. Wittayanan, D. Ogden, T. Furuta, Y.Kurakawa and M. Goeldner*
New photoremovable protecting groups for carboxylic acids with high photolytic efficiencies at near-UV irradiation. Application to the photo-controlled release of glutamate.
(2006) ChemBioChem In press
124.
M. Goeldner
Caging of ATP and Glutamate : A comparative analysis (2005) in « Dynamic studies in Biology : Phototriggers, photoswitches and caged biomolecules » pp 76-94, M Goeldner & R. Givens Eds, Wiley -VCH
125.
L. Peng and M. Goeldner
Photoregulation of proteins : Caged enzyme modulators.(2005) in « Dynamic studies in Biology : Phototriggers, photoswitches and caged biomolecules » pp 303-324, M. Goeldner & R. Givens Eds, Wiley VCH .
126.
M. Goeldner R. Givens
Foreword (2005) in « Dynamic studies in Biology : Phototriggers, photoswitches and caged biomolecules » pp
M Goeldner, R. Givens Eds, Wiley VCH
127 . D. Berezhnoy, R. Baur, A. Gonthier, B. Foucaud, M. Goeldner, E. Sigel
Conformational changes at benzodiazepine binding sites of GABA
(2005) J. Neurochem. 92, 859-866.
128.
A. Specht, F. Ziarelli, Ph. Bernard, M. Goeldner L. Peng
A
receptors detected with a novel technique para -Sulfonated calixarenes used as synthetic receptors for complexing photolabile cholinergic ligands
(2005) Helv. Chim. Acta 88, 2641-2653.
129 A Mourot, J. Rodrigo, F. Kotzyba-Hibert, S. Bertrand, D. Bertrand, M. Goeldner
4

Probing the reorganization of the nAChR during desensitization by time-resolved covalent labeling using [ 3 H]
AC
5
, a photoactivatable agonist. (2006) Mol. Pharmacol. 69, 452-461.
130.
A. Mourot, Th. Grutter, M. Goeldner and F. Kotzyba-Hibert
Dynamic structural investigation on the Torpedo nicotinic acetylcholine receptor using time-resolved photoaffinity labeling. (2006) ChemBioChem 7, 570-583.
131. A. Specht , J-S. Thomann, K. Alarcon, W. Wittayanan, D. Ogden, T. Furuta, Y.Kurakawa and M. Goeldner
New photoremovable protecting groups for carboxylic acids with high photolytic efficiencies at near-UV irradiation. Application to the photo-controlled release of glutamate.
(2006) ChemBioChem. 7, 1690-1695.
132.
E. Sakr, F. Kotzyba-Hibert, J. Grandl, R. Hovius, H. Vogel, S. Bertrand, D. Bertrand and M. Goeldner
Engineered site-directed lableling of nicotinic acetylcholine receptors usingb reactive epibatidine derivatives.
(2006) J. Mol. Neurosci. 30, 35-36.
133. Mourot, Alexandre; Rodrigo, J.; Bertrand, Sonia; Bertrand, Daniel; Goeldner, Maurice;Kotzyba-Hibert,
Florence.
Reorganization of the nicotinic acetylcholine receptor during desensitization probed with a photoactivatable agonist (2006) J. Mol. Neurosci. 30, 13-14.
134.
Mourot, Alexandre; Kotzyba-Hibert, Florence; Goeldner, Maurice; Bamberg, Ernst. Photo-induced covalent attachment of agonists as a tool to study allosteric mechanisms of nicotinic acetylcholine receptors. (2006) J. Mol. Neurosci. (2006), 30, 3-4.
135.
J. Grandl, E. Sakr, F. Kotzyba-Hibert, F. Krieger, S. Bertrand, D. Bertrand , H. Vogel, M. Goeldner,
R. Hovius.
Fluorescent agonists based on epibatifdine for neuronal and muscle-type nicotinic acetylcholine receptors. (2007) Angew. Chemie Int. Ed. Engl. Sous presse
En révision
136.
K. Tan, A. Gonthier, R. Baur, M. Goeldner, E. Sigel
Proximity-accelerated chemical coupling reaction in the benzodiazepine site of GABA
A
receptors :
Superposition of different allosteric modulators. J. Neurochem.
137.
B. Foucaud, K. Alarcon, E. Sakr , M. Goeldner
Binding-site chemical probing in homology models using affinity labeling of cysteine-substituted receptors.
Current Chem. Biol .
Book : 2005 « Dynamic studies in Biology : Phototriggers, photoswitches and caged biomolecules » M. Goeldner & R. Givens Eds, Wiley VCH .
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