Graduate Neuroscience Program Section 1. Introductory section The interdisciplinary Neuroscience Program was established in 1978. In May we had a "Celebration of 30 years of Neuroscience at UW" (discussed below). For most of those years, students interested in Neuroscience were admitted through traditional home departments (Psychology was the original dominant home). Since 2001, the core faculty for Neuroscience has been in the Department of Zoology and Physiology, and in the School of Pharmacy. In 2001 there was the transition from a degree awarded in a home department to a free standing, doctoral degree in Neuroscience. The doctoral program in Neuroscience admitted its first two students in 2002. Those students graduated with the PhD in May. Since that time we have admitted 2-4 students per year. In 2004 we admitted the first masters in Neuroscience student and he graduated in May. Currently several students have completed their qualifying exams and have had dissertation proposal meetings. We anticipate three students to graduate with the PhD in May 2008, and one student with a master's in Neuroscience. Thus, students are in various stages in the pipeline towards receiving the graduate degrees in Neuroscience. The Neuroscience Program is growing with the addition of students. Graduate students have been successful publishing and receiving external funding to support their graduate education. For example, Gwen Haley received a NSF fellowship to work in a neuroscience laboratory in Australia, where she learned a variety of new techniques. Graduate students are publishing in top tier (high impact) journals and the journals of record for their field, such as the American Journal of Physiology (journal of record for American Physiological Society) and Journal of Neuroscience (journal of record for the Society for Neuroscience). Faculty in the Neuroscience Program have national and international recognitions. Several serve on editorial boards for Neuroscience journals and grant review panels. Neuroscience Faculty have been invited to give key note lectures at international conferences, invited seminars at various universities, and invited lectures at conferences. Their success in securing grant funding is presented below. The quality of the faculty is perhaps best highlighted by the success at the award of a NIH Neuroscience Center grant (see below). Two doctorate degrees in Neuroscience awarded in May (both students have accepted post doctoral training positions) First Masters degree in Neuroscience awarded (student entering WWAMI Medical Program) $10.4 MILLION dollar Neuroscience Center grant renewed for 5 years Minor in Neuroscience established Recruited for two new Neuroscience faculty- searches were unsuccessful (candidates took other positions) and these searches will be opened again this year. Visions for Neuroscience graduate study. The overarching goal of the Neuroscience Program and its faculty are to provide students with a highly competitive graduate education. Provide an intellectual and exciting educational environment conducive to graduate education and that instills excitement in the Neurosciences. Expand the number of faculty that participate in the Neuroscience Program, through new hires and involving existing faculty. This will be essential for the expansion of the number of students in the program and the development of Programmatic Grants, such as Training grants for Predoctoral and postdoctoral students. Work cooperatively with University of Wyoming administration to build on the standing of Neuroscience as recognized Area of Distinction in the University to create a well-funded Neuroscience Center with a larger critical mass of productive faculty and strong, viable core infrastructure, and a strong graduate student enrollment. As faculty involvement and diversity increases, we seek to increase the number and variety of 1 Graduate Neuroscience Program coursework suitable for students in neuroscience. Continue to obtain individual and Neuroscience Center or Training grants to support graduate training and provide students and faculty access to state-of-the-art equipment (e.g. Microscopy and Macromolecular Core Facilities that have received significant support from the Neuroscience Center grants). Section 2. Academic Planning Implementation: Faculty expansion in the Neurosciences. Involvement of existing UW faculty. The Neuroscience Program has an “open door” policy. Faculty with an interest in the neurosciences are welcome to attend the neuroscience seminar, invite speakers for the Neuroscience Seminar Series (paid for by the Neuroscience Center grant), and to admit students through the Neuroscience Program. Presently faculty in the Neuroscience Program are housed in the Colleges of Arts & Sciences (n=6), Health Sciences (n=6), Engineering (n=1), and Agriculture (n=3). Develop a "critical mass" of neuroscience faculty. The university committed at least three and possibly four positions to the neurosciences (in letter from President Buchanan to the NIH). We advertised and interview for two positions this past year. Unfortunately neither search was successful. In both cases, spousal requirements could not be met. The candidates themselves were quite satisfied with the start up packages (provided by the Neuroscience Center grant) and the neuroscience environment at UW. We hope to readvertise for both positions in August (neuropharmacology [School of Pharmacy] and neuroanatomy [Department of Zoology & Physiology]). Thus we are working toward fulfillment of the action items and the commitment to the National Institutes of Health. Section 3. Teaching Activities: Undergraduate and graduate courses in the neurosciences are offered through home departments: the School of Pharmacy and Department of Zoology and Physiology. Additional course work is provided in the Departments of Molecular Biology, Animal Science, and Electrical and Chemical Engineering, and Psychology. Neuroscience Program recognizes that teaching goes beyond the classroom, and beyond UW. Funding opportunities are available for Neuroscience Graduate students to travel to laboratories to learn new techniques and to advance their graduate education. This summer Dane Jensen attended the University of Liverpool, England where he worked with Dr. John Quinn. Techniques learned from Dr. Quinn are directly applicable to Dane's doctoral research project. Participation at conferences is an important teaching mechanism. All Neuroscience Graduate students are encouraged to attend and to present at the Annual Society for Neuroscience Conference. All Neuroscience students are fully funded (all travel costs paid) to attend the conference through either their faculty grants and/or the Neuroscience Center grant. Success in the Neurosciences requires that students formulate testable research hypotheses and then have whatever technique/tool that is needed to address the hypothesis. Students and faculty in the neurosciences move easily from behavior to electrophysiology to neuroanatomy to cell biology to genomics and back. To ensure that our educational objectives for graduate neuroscience students are met, students are encouraged to interact with several neuroscience faculty and learn a variety of techniques. Seminar Series. The Neuroscience Program funds an active Seminar Series that provides a unique educational experience for both students and faculty. This weekly seminar is open to the entire UW community. Approximately 20 invited speakers from the US, Europe (England, Hungary), and Brazil were invited here during the past academic year. In addition, a number of UW Neuroscience faculty 2 Graduate Neuroscience Program provided seminars. The Neuroscience Center paid $21,991.86 to support the Neuroscience Seminar Series during the past academic year. Section 4. Research and/or Creative Activities: Neuroscience Program The Neuroscience Center Grant (F.W. Flynn, principal investigator) was renewed for 5 years at a total cost in excess of $10 million ($2 M/year direct costs). Year 2 noncompeting renewal was prepared and submitted in May. Faculty Grant activities during past academic year- Faculty submitted a variety of federal research grants. F. Flynn- NIH continuation of RO1 DK50586, direct ~$175,000 (yearly direct); new grant RO1 NS58763- scored 9th percentile- but not funded; resubmitted 7/1. Z. Fuzessery- renewal of NIH grant R01DC005202-06; funded- 5 years start 8/1/07 $250,000 (yearly direct) Q. Sun- R01NS057415- Funded. direct $125,000. 1R01MH081885- submitted but Not funded Sreejayan- submitted NIH 1R15AT004269-01, Not funded C. Woodbury, continuation of RO1 NS44094, 5 year renewal of NIH grant, pending D. Skinner, NSF new grant #0616109- ranked High Priority, but not funded; resubmitted #0745084, 7/12 J. Jewel- Wyoming Wildlife/Livestock Disease Research Partnership 2006 (USDA CSREES): 09/01/06 – 08/30/08. $85,940 total. USDA CSREES NRI grant: $134,687. 09/01/07 – 8/31/08. WW/LDRP 2007 $100,144. 07/01/07 – 09/30/08. J. Ren . NIH/NIAAA R01 (1R01 AA013412-01A2): $200,000 (yearly direct) (4/1/043/31/09). G. Leedy. R03 submitted to NIH 1R03MH082332-01, Section 5. Service Activities: The Neuroscience Program and the Neuroscience Center grant provides a service by maintaining the Microscopy Facility that is available to this campus. The Neuroscience Center grant pays for the service contracts for the major microscopes (TEM, confocal) and equipment upgrades. A new scanning electron microscopy ($65,000) was purchased for the facility through the Neuroscience Center grant. Software upgrades for image analysis were paid by the Neuroscience Center grant. This service impacts not only neuroscience graduate students and faculty, but all graduate students requiring the imaging capabilities that are enabled by the Neuroscience Center grant. In total the Neuroscience Center provided a total of $186,449.16 to support the Microscopy Facility. The Neuroscience Seminar Series provides an educational service to the university. Section 6. Student Recruitment and Retention Activities and Enrollment Trends: Undergraduate: Neuroscience faculty developed a proposal for a minor in Neuroscience that was approved in the past academic year. We need a web site that promotes the minor in Neuroscience. Graduate: We receive approximately 15 applications each year for admission to the doctoral Neuroscience Program. Applications for the masters program have been from "in house" students. The students applying for the masters ultimately seek admission to medical school or the doctoral program in Neuroscience. We have an excellent student retention with all but 2 students that were admitted to the doctoral Neuroscience Program either having graduated or are still students advancing in the program. Efforts on retention focus on providing the students with a unique, rewarding , and personal learning experience. Student to faculty ratios are very low, averaging 2:1. 3 Graduate Neuroscience Program While this may be viewed as a negative when bean counting, the benefit to the students is that the faculty advisor works closely with each student. Students are not just a number or a face on the crowd, all of the neuroscience faculty know the graduate students. This sense of family is promoted by the low students to faculty ratio and the Neuroscience Seminar on Monday evenings for which all participants in the Neuroscience Program are encouraged to attend. Also, students have ready access to state-of-the art equipment. The Neuroscience Center grant provides significant financial support for the Microscopy Facility and students can use the transmission electron microscope or the confocal microscopes. The use of the facility is such that students can learn to use the systems and not feel rushed. There are no boundaries that would discourage or prevent neuroscience students from working in a variety of laboratories. Students can move between labs to learn different techniques and to interact with their peers. Recruitment efforts. Recruitment strategy is largely word-of-mouth (contacting former students, colleagues, etc) and via the web site. A representative from the Neuroscience Program attends the regional Neuroscience meetings and disseminates information about Wyoming Neuroscience. Section 7. Development activities and public relations. A. Faculty Development and teamwork. This is the heart of the Neuroscience Center grant. A primary objective is to cultivate neuroscience at UW. Faculty development and grantsmanship are a priority and internal mentors assist in the scientific maturation of neuroscience faculty colleagues. Mentors are senior neuroscience faculty with a history of grant funding and service on federal (NIH, NSF) review panels. The mentors include Drs. Flynn, Fuzessery, Woodbury, and Ren. The role of the mentor is to educate the investigator on how to write a fundable proposal and to deal with Summary Statements and resubmissions, if required. We envision mentoring to be a multi-tiered process. UW faculty serve as day-to-day mentors for the junior and early career faculty. In addition, we have recruited six external mentors to serve on the Neuroscience Advisory Panel. These external advisors will review the scientific accomplishments of the investigators twice per year during the External Advisory Committee meeting and provide guidance and feedback. Thus each junior investigator will be mentored by an on campus mentor and an external advisor who is an expert in that area related to the junior investigator. External mentors can provide a critical evaluation of the research plan and we will arrange for investigators to visit the external mentor’s lab. In visiting the mentor’s lab, the investigator will receive specialized training and collaborative projects may be identified. Both outcomes will serve to facilitate the career development of the investigator. The Neuroscience Seminar Series will provide another venue for career development. Investigators are strongly encouraged to invite speakers with research expertise related to their projects. Our goals are two fold. First, we expect that the speaker will introduce the investigator to new approaches to study their research area. Second, collaborations may develop between the investigator and the speaker. The Neuroscience faculty are a tight knit group. The cohesiveness of this group is promoted by the fact that the majority of the faculty (voluntarily) attend the Neuroscience Seminar class, which has been held every semester (Monday evening) for 30 years. This is as much of a social interaction as it is a learning situation. Overall the environment facilitates communication among all of the neuroscience students and faculty. B. PR activities. Web site. We used the university PR department to develop a Neuroscience Web site. We have not been at all satisfied in dealing with the Web Development people at UW and while a new web site is up a running, we are hiring an outside person to redevelop the web site. In the report I just received, Neuroscience received 12,000 hits http://webdev.uwyo.edu/web%5Fstatistics/CMSStats/). 4 Graduate Neuroscience Program 30 Years of UW Neuroscience Celebration. In May we had a one day celebration of Neuroscience at UW. The Neuroscience Program started 30 years ago at UW. To celebrate our accomplishments and those of our students, the Center grant paid travel costs for our former students to return to UW for one day Retreat. Current students and faculty, and former students had the opportunity to reflect on the neuroscience program, and especially how the program and the facilities have grown. During the day, former and current students delivered research presentations. The day ended with a banquet at the Foundation House. This was modeled after the Neuroscience Retreat which was held on campus for about 10 years. The Retreat ended due to a lack of funding. Now, with the Neuroscience Center grant we plan on reinstating the yearly Neuroscience Retreat at UW. Graduate Neuroscience Student Award. One way of acknowledging our doctoral students is to provide a yearly award. This award promotes a sense of pride and recognition among the students. Students are nominated and voted on by the neuroscience faculty. The selection is based on leadership within the Neuroscience Program, research accomplishments, and academic performance. The award carries a $200 prize. Front Range Neuroscience Group. For 4 years, UW Neuroscience has participated actively in this chapter of the Society for Neuroscience. At an annual meeting, graduate and undergraduate students compete against students from UC Boulder, UC Denver and CSU and have consistently been highly rated. In the past academic year, Leah Selby (Sun Lab) was awarded the top undergraduate poster presentation and Dane Jensen (Flynn lab) received the Outstanding Graduate Student Presentation. Section 8. Classified and Professional Staffing: A full time bookkeeper oversees the Neuroscience Program grant (>$10 M). Ms. Gonzales does an excellent job and her recruitment was a complete success. Budget information is immediately available on any of the Neuroscience related accounts. She maintains and oversees the budgets for the investigator research projects, Neuroscience Graduate Student stipends, Neuroscience Seminar Series, and the Center budget for the Microscopy Facility. She does regular secretarial work that assists the Director (Flynn). She coordinates travel of the external advisors during their yearly visit, and the travel for seminar speakers, and for Neuroscience Center grant investigators. Now that the oversight of the Neuroscience grant is out of Zoology and Physiology bookkeeping things are going incredibly well. (sure you want this last sentence…reading between the lines…) Section 9. Diversity: Faculty hires are through home departments who set the guidelines for diversity. The faculty of the Neuroscience Program are diverse and includes minority and women. We also have diversity in our scientific expertise and neuroscience training opportunities that we provide undergraduate and graduate students. Each search that has involved the Neuroscience Program has included highly qualified female candidates who have advanced to the final three who are invited in for job interviews. This year, Dr. Suzanne Clark was offered and accepted a tenure track position in the School of Pharmacy. She is already an active participant in the Neuroscience Program. Section 10. Assessment of Student Learning: A. The Neuroscience program has not published at this site the goals. The following Benchmarks: Doctoral Degree in Neuroscience was provided in the Neuroscience Vision Statement. a. During the first semester, students are required to take Introduction to Neuroscience (Zoo 5280), and complete by the end of the second year Structure and Function of the Nervous System (ZOO 5100) and Neurophysiology (ZOO 5685 or 5670). A grade of B or better is required for Neuroscience course work. Classes receiving a 5 b. b. c. d. e. e. f. g. h. Graduate Neuroscience Program deficient grade will be repeated or arrangements will be made with the instructor to correct the deficiency. Neuroscience Seminar. Students are required to take the Seminar in Neuroscience each semester while in residence at UW. Graduate students are required to maintain a B average or better during their residency. During the first semester, students, with the guidance of their academic advisor, will form an advisory committee. The committee will consist of a minimum of four members of faculty in the Neuroscience Program. This group will serve as the mentoring committee for the student during his/her initial years of graduate training. This committee will meet and advise the candidate's course and research program by the end of the second semester in the program. A formal Master’s degree project is not presently required for doctoral students but a master’s level neuroscience proficiency is expected to be demonstrated. This will be demonstrated by a research project that will be identified during year 1. The benchmarks for the successful completion of the master’s level research will be the: 1) presentation of the research at national/international meeting; 2) presentation of the work during the Physiology Seminar or in a prearranged seminar, with questions; and 3) the publication of the work in a refereed Neuroscience journal. Seventy-two (72) hours of course work including 42 hours of formal coursework at the 4000 level or above from this or other accredited university graduate programs. The Program of Study should be approved by the committee before the end of the second semester and approved by the Graduate Dean. Research tool. It is the responsibility of the student’s advisory committee to ensure appropriate breadth of coursework and knowledge of Neuroscience, as assessed by the preliminary examination. No formal certification of a “tool,” as designated by some departments, will be required by the Neuroscience Program. Preliminary exam. The final examination is comprehensive, covering all areas of Neuroscience, but emphasizing the student’s area or expertise. The format of the preliminary exam will consist of both a written and oral portion. The format of the exam will be determined by the student’s graduate committee. The written portion may take the form of literature reviews, open or closed book questions, experimental design questions, etc. Students should take the preliminary exam in their fifth semester of graduate study, after completing most of their graduate coursework and their masters level research project. The work will at least have been submitted for publication. An examination committee will consist of the student’s graduate committee and a member assigned by the Graduate Faculty. The composition of the Committee will be approved by the Neuroscience Advisory Group (NAG) and the Graduate School. Assessment of a student's performance will remain the responsibility of the student's graduate committee. Students who do not perform satisfactorily in regards to the research proposal and preliminary exam may be dropped from the graduate program upon the recommendation of the student's graduate committee and the Program Director. Research Proposal. Students must have satisfactorily passed the Preliminary exams before advancing to the dissertation research. Doctoral students must write a dissertation following guidelines of the Graduate School of the University of Wyoming. The student will prepare a written proposal that will be submitted for review by the student's advisory committee. The committee will evaluate the: 1) originality; 2) quality, and 3) rigor of the dissertation research. Time schedule -- In 6 Graduate Neuroscience Program general, it is recommended that the student present the research proposal during year 3 of his or her doctoral studies. i. Advancement to candidacy for the Ph.D degree. For advancement to candidacy for the Ph.D degree, students must have successfully completed the following requirements: 1) benchmarks for Master’s level research proficiency (outlined in II); 2) committee-approved program of study; 3) preliminary exam; and 4) committeeapproved research proposal. j. Neuroscience faculty will meet at the end of the Spring semester to review the graduate students. The student’s advisor and advisory committee will have the responsibility of summarizing the student’s progress and making recommendations regarding funding, the student’s status in the program, and advancement to degree candidacy. The review will be summarized in letter form and discussed with the student. k. Teaching experience. All graduate students are expected to have obtained teaching experience. Students are not expected to serve as teaching assistantships while supported by external, federal grants. However, state-funded assistantships will be rotated to fund students while serving as teaching assistantships for Neuroscience courses. Sequence of well defined benchmarks during the graduate experience that reflects critical skills and depth of learning. The objectives are to have the student become capable of independent research and scholarship. The benchmarks reflect this progression of the student during the graduate education. Benchmarks include the student learning: 1) the relevant literature and having a broad appreciation of neuroscience, 2) research design and experimental techniques to address the research question, 3) scientific writing and the publication process, 4) collegiality and scientific ethics; 5) communication skills, for research presentations and teaching, 6) independence. B. Assessment activities for this past year. The following data were collected from faculty and students. 1. Number of student publications and presentations. 2. Number of grant submissions from neuroscience participating faculty. 3. Grant success of junior neuroscience faculty. 4. Number of editorial boards that faculty serve on. 5. Number of invited lectures, seminars, articles. 6. Number of users for the Microscopy Facility and equipment needs (in conjunction with Dr. Zhang). We have no planned changes. C. Mechanisms for tracking graduates. At this time, graduates from the Neuroscience Program are tracked through contact with our former students. 1) The Annual Society for Neuroscience Conference attracts the vast majority of neuroscientists worldwide. Our former students attend this meeting and future graduate students would similarly be expected to attend this conference. In the past, graduates from the UW Neuroscience Program and neuroscience faculty have arranged get togethers. While informal, this annual meeting provides a venue with which to maintain contact with Neuroscience graduates and to track their career progress. We see our former students regularly at meetings and tracking their progress is easily accomplished. Furthermore, a number of our former students have returned to UW to deliver seminars. 7 Graduate Neuroscience Program 2) We presently have a list of the graduates in Neuroscience for the past 20 years. Former students can be contacted by e-mail or by phone. If support personnel are available, we will develop an assessment questionnaire that asks for comments on the graduate’s current position, feedback on the graduate education provided at UW, and other issues to be identified. 3) Neuroscience Retreats and celebrations. This year we arranged for a "Celebration of 30 years of Neuroscience at UW". Former students were invited and funds were available (from the Neuroscience Center grant) for their travel expenses. This was the first such retreat we organized and it was very successful and provided a mechanism to learn of our former students successes. Success measures for graduates: 1) Permanent employment in the Neurosciences. The positions may be in clinical settings, academics, industry, or pharmaceutics. 2) Career Recognition. The success of graduates in obtaining external funding (where appropriate for thee position), or awards for their accomplishments. 3) Upon completion of the graduate program (either MS or PhD) students may elect to enter professional programs, such as medical or dental school. The ability of graduates to be admitted to and complete such programs will be taken as a measure of success. 8