Name:
Short Curriculum Vitae-
Prof. Fabrizio Palitti
Academic Address: Università degli Studi della Tuscia
Dipartimento di Agrobiologia e Agrochimica
Via S. Camillo de Lellis
01100 Viterbo - Italy-
Citizenship:
Date of birth:
Italian
July 25, 1945
Actual position: Full professor of Genetics
University of Tuscia
Faculty of Biological Sciences.
1968: Graduate Degree in Biological Sciences, University of Rome, 1968.
1 Feb. 1973 to June 1986 has worked as Scientist (Genetic Toxicologist) in
Centro di Genetica Evoluzionistica of the National Research Council
(C.N.R.) c/o University of Rome.
He was awarded a fellowship of the CNR for one year (1974) to spend in
Uppsala, Sweden, working with Prof.B.A. Kihlman at the Department of
Genetics, Royal Accademy of Science.
He was awarded an EMBO fellowship in 1978 to work with Prof. A.T.
Natarajan in the Department of Radiation Genetics and Mutagenesis,
Leiden University, Leiden, The Netherlands.
From 1986 Full professor of Genetics in the University of Tuscia (Viterbo)
Italy, Faculty of Biological Sciences.
During the past 35 years of activity, Prof. Palitti has gained a wide experience in the fields of Radiogenetics and Genetic Toxicology. He has mainly been involved on the molecular mechanisms of induction of

chromosomal aberrations and SCE's. He has more than 100 papers published in international journals.
He has taken part and he is taking part in several Projects coordinated by the European Economic Communities, by the International Atomic Energy
Agency , Spaziale Italiana and Philip Morris External Research Program.
He is on the Editorial Board of "Mutation Research"and he frequently asked to act as referee for several scientific journals in the field of his expertise.
Expert advice in the field of radiation protection of IAEA
Member of ISO group on biological dosimetry
Most significant scientific publications (1998-2006)
P. BELLONI a , R. MESCHINI a , S. CZENE b , M. HARMS-
RINGDAHL b and F. PALITTI Studies on radiation induced apoptosis in G
0
human lymphocytes) IJRB 81(2005):587-599.
Claudia Lorenti Garcia, Silvia Filippi, Pasquale Mosesso, Menotti
Calvani*, Raffaella Nicolai*, Luigi Mosconi* and Fabrizio Palitti. The protective effect of L-Carnitine in peripheral blood human lymphocytes exposed to oxidative agents.Mutagenesis 21(2006):21-27
Fredrik Johansson , Anne Lagerqvist, Silvia Filippi , Fabrizio Palitti,
Klaus Erixon, Thomas Helleday, Dag Jenssen Caffeine delays replication fork progression and enhances UV-induced homologous recombination in Chinese hamster cell lines. DNA Repair (2006):1449-
58.
M. V. Di Tomaso , W. Martínez-López, G. A. Folle , F. Palitti.
Modulation of chromosome damage localization by DNA replication time.IJRB 82(2006):877-886
P.MOSESSO, M.PIANE, PALITTI F., G.PEPE, S.PENNA, L.CHESSA
(2005). THE NOVEL HUMAN GENE APRATAXIN
IS DIRECTLY INVOLVED IN dna SINGLE-STRAND-BREAK
REPAIR. CELLULAR AND MOLECULAR LIFE SCIENCES.

vol. 62 pp. 485-491 ISSN: 1420-682X
DE GRASSI F, FIORE M, PALITTI F. (2004). Chromosomal
Aberrations and Genomic Instability Induced by
Topoisomerase- Targeted Antitumor Drugs. CURRENT MEDICINAL
CHEMISTRY. vol. 4 pp. 317-325 ISSN: 0929-8673
MARTNEZ-LPEZ W, FOLLE GA, CASSINA G, MNDEZ-ACUNA L,
DI.TOMASO MV, OBE G, PALITTI F. (2004).
Distribution of breakpoints induced by etoposide and x-rays along the
CHO X chromosome. CYTOGENETIC AND
GENOME RESEARCH. vol. 104 pp. 182-187 ISSN: 1424-8581
MOSESSO P, PENNA S, PEPE G, LORENTI GARCIA C, PALITTI F.
(2004). Potassium bromate but not X-rays cause unexpectedly elevated levels of DNA breakage similar to those induced by ultraviolet light in Cockayne syndrome (CS-B) fibroblast. CYTOGENETIC AND GENOME RESEARCH. vol. 104 pp. 178-181 ISSN: 1424-8581
PALITTI F. (2004). Mechanisms of formation of chromosomal aberrations: insights from studies with DNA repair-deficient cells. CYTOGENETIC AND GENOME RESEARCH. vol. 104 pp. 95-
99 ISSN: 1424-8581
BASSI LOREDANA, CARLONI MANUELA, MESCHIUNI
ROBERTA, FONTI ENRICA, PALITTI F. (2003).
X-IRRADIATED HUMAN LYMPHOCYTES WITH UNSTABLE
ABERRATIONS AND THEIRPREFERENTIAL
ELIMINATION BY P53/SURVIVIN-DERPENDENT APOPTOSIS.
INTERNATIONAL JOURNAL OF RADIATION
BIOLOGY. vol. 12 pp. 943-954 ISSN: 0955-3002
FRANCHITTO A, PICHIERRI P, PIERGENTILI R, CRESCENZI M,
BIGNAMI M, PALITTI F. (2003). The mammalian mismatch repair protein MSH2 is required for correct MRE11 and
RAD51 relocalization and for efficient cell cycle arrest

induced by ionising radiation in G2 phase. ONCOGENE. vol. 22 pp.
2100-2120 ISSN: 0950-9232
ADABALAYAM S. BALAJEE, PALITTI F. (2003). SENSITIVITY
OF WERNER'S CELLS TO DNA DAMAGING AGENTS
INSIGHT TO THE BIOLOGICAL FUNCTION OF WERNER
PROTEIN. In MICHEL LEBEL MOLECULAR MECHANISMS
OF WERNER'S SYNDROME (pp. 1-16).: EUREKA.COM
PROIETTI DE SANTIS L, BALAJEE AS, LORENTI GARCIA C,
PEPE G, WORBOYS AM, PALITTI F. (2003). Inhibition of p53, p21 and Bax by pifithrin-a does not affect UV induced apoptotic response in CS-B cells. DNA REPAIR. vol. 2 pp.
891-900 ISSN: 1568-7864
L.BASSI, M.CARLONI, E.FONTI, N.PALMA DE LA PENA,
R.MESCHINI, PALITTI F. (2002). PIFITHRIN-a, AN
INHIBITOR OF P53,ENHANCES THE GENETIC INSTABILITY
INDUCED BY ETOPOSIDE (VP16) IN HUMAN
LYMPHOBLASTOID CELLS TREATED IN VITRO. MUTATION
RESEARCH. vol. 499 pp. 163-178 ISSN: 0027-5107
P.VOISIN, F.BARQUINERO, B.BLAKELY, C.LINDHOLM,
D.LLOYD, C.LUCCIONI, S.MILLER, PALITTI F.,
P.G.S.PRASANNA, G.STEPHAN, H.THIERENS, I.TURAI (2002).
TOWARDS A STANDARDIZATION OF BIOLOGICAL
DOSIMETRY BY CYTOGENETICS. CELLULAR AND
MOLECULAR BIOLOGY. vol. 48 pp. 501-504 ISSN: 0145-5680
L.PROIETTI DE SANTIS, C.LORENTI GARCIA, ADABALAM S.
BALAJEE, P.LATINI, P.PICHIERRI, OSAMU
NIKAIDO, M.STEFANINI, PALITTI F. (2002). TRASCRIPTION
COUPLED REPAIR EFFICIENCY DETERMINES THE
CELL CYCLE PROGRESSION AND APOPTOSIS AFTER UV
EXPOSURE IN HAMSTER CELLS. DNA REPAIR. vol. 1 pp.
209-223 ISSN: 1568-7864

CARLONI M., MESCHINI R., OVIDI L., PALITTI F. (2001). PHA-
INDUCED CELL PROLIFERATION RESCUES
HUMAN PERIPHERAL BLOOD LYMPHOCYTES FROM X-RAY
INDUCED APOPTOSIS. MUTAGENESIS. vol. 16, V 2 pp. 115-120 ISSN: 0267-8357
FRANCHITTO A., PICHIERRI P, GENUARDI M, DE SANTIS A,
PALITTI F. (2001). Investigation of G2-phase chromosomal radiosensitivity in hereditary non-polyposis colorectal cancer cells. INTERNATIONAL JOURNAL OF
RADIATION BIOLOGY. vol. 77 pp. 773-780 ISSN: 0955-3002
LORENTI GARCIA C., CARLONI M., PALMA DE LA PENA N.,
FONTI E., PALITTI F. (2001). DETECTION OF DNA
PRYMARY DAMAGE BY PREMATURE CHROMOSOME
CONDENSATION (PCC) IN HUMAN PERIPHERAL BLOOD
LYMPHOCYTES TREATED WITH METHYL
METHANESULPHONATE (MMS). MUTAGENESIS. vol. 16 V 2 pp.
121-125
P.PICHIERRI, A.FRANCHITTO, P.MOSESSO, PALITTI F. (2001).
Werner's Syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of the cell cycle. MOLECULAR BIOLOGY OF THE
CELL. vol. 12 pp. 2412-2421 ISSN: 1059-1524
PIETRO PICHIERRI, ANNAPAOLA FRANCHITTO, RITA
PIERGENTILI, CLAUDIA COLUSSI, PALITTI F. (2001).
Hypersensitivity to camptothecin in MSH2 deficient cells is correlated with a role for MSH2 protein in recombinational repair. CARCINOGENESIS. vol. 22 pp. 1781-1787 ISSN: 0143-3334
PROIETTI DE SANTIS L., LORENTI GARCIA C., BALAJEE A.S.,
BASSI L., PALITTI F. (2001). TRANSCRIPTION
COUPLET REPAIR DEFICIENCY RESULTS IN INCREASED
CHROMOSOMAL ABERRATIONS AND APOPTOTIC
DEATH IN HAMSTER HOMOLOGUE OF HUMAN COCKAYNE
SYNDROME GROUP B CELLS. MUTATION

RESEARCH. vol. 485 pp. 121-132 ISSN: 0027-5107
BASSI L., BUZZI R., FIORE M., PALITTI F. (2000).
CLASTOGENIC EFFECTS OF TWO TYROSINE KINASE
INHIBITORS, TYRPHOSTIN 23 AND TYRPHOSTIN 46, ON
TRANSFORMED (CHO-K1) AND ON A PRIMARY
EMBRYONIC CHINESE HAMSTER CELL LINE (CHE).
MUTAGENESIS. vol. 15 pp. 341-347 ISSN: 0267-8357
FRANCHITTO A., PICHIERRI P., MOSESSO P, PALITTI F. (2000).
CATALYTIC INHIBITION OF TOPOISOMERASE II
IN WERNER'S SYNDROME CELL LINES ENHANCES
CHROMOSOMAL DAMAGE INDUCED BY X-RAYS IN G2
PHASE
OF THE CELL CYCLE. INTERNATIONAL JOURNAL OF
RADIATION BIOLOGY. vol. 76 pp. 913-922 ISSN: 0955-3002
MOSESSO P., PICHIERRI P., FRANCHITTO A., PALITTI F. (2000).
EVIDENCE OF CAMPTHOTECIN-INDUCED
ABERRATIONS IN THE G2 PHASE OF THE CELL CYCLE OF
CHINESE HAMSTER OVARY (CHO) CELL LINES IS
ASSOCIATED WITH TRANSCRIPTION. MUTATION RESEARCH. vol. 452 pp. 189-195 ISSN: 0027-5107
PICHIERRI P., FRANCHITTO A., MOSESSO P., PROIETTI DE
SANTIS L., BALAJEE AS., PALITTI F. (2000). Werner syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle.
MUTATION RESEARCH. vol. 459 pp. 123-133 ISSN: 0027-5107
MOSESSO P., FONTI E., BASSI L., LORENTI GARCIA C., PALITTI
F. (1999). THE INVOLVMENT OF CHROMATIN
CONDENSATION IN CAMPTOTHECIN-INDUCED
CHROMOSOME BREAKS IN G0 HUMAN LYMPHOCYTES.
MUTAGENESIS. vol. 14 pp. 103-105 ISSN: 0267-8357
PALITTI F., PICHIERRI P., FRANCHITTO A., PROIETTI DE
SANTIS L., MOSESSO P. (1999). Chromosome

radiosensitivity in human G2 lymphocytes and cell-cycle progression.
INTERNATIONAL JOURNAL OF RADIATION
BIOLOGY. vol. 75 pp. 621-627 ISSN: 0955-3002
BASSI L., PALITTI F., MOSESSO P., NATARAJAN AT (1998).
Distribution of camptothecin-induced breakpoints in
Chinese hamster cells treated in late-S and G2 phases of the cell cycle.
MUTAGENESIS. vol. 13 pp. 257-261 ISSN:
0267-8357
PALITTI F. (1998). Mechanisms of formation of chromosomal aberrations. MUTATION RESEARCH. vol. 404 pp. 133-137
ISSN: 0027-5107
BASSI L, PALITTI F., MOSESSO P, NATARAJAN AT (1998).
Distribution of camptothecin-induced break points in
Chinese hamster cells treated in late S and G2 phases of the cell cycle.
MUTAGENESIS. vol. 13 pp. 257-261 ISSN:
0267-8357
MOSESSO P, DARROUDI F, VAN DEN BERG M, VERMEULEN S,
PALITTI F., NATARAJAN AT (1998). Induction of chromosomal aberrations (unstable and stable) by inhibitors of topoisomerase II, m-AMSA and VP16, using conventional
Giemsa staining and chromosome painting techniques.
MUTAGENESIS. vol. 13 pp. 39-43 ISSN: 0267-8357
MOSESSO P, FONTI E, BASSI L, PALITTI F. (1998). The involvement of chromatin condensation in camptothecin-induced chromosome breaks in G0 human lymphocytes.
MUTAGENESIS. vol. 14 pp. 103-105 ISSN:
0267-8357
FRANCHITTO A., PICHIERRI P., MOSESSO P., PALITTI F. (1998).
Caffeine effect on mitotic delay induced by
G2-treatment with UVC or Mitomycin-C. MUTAGENESIS. vol. 16
V.1 pp. 499-505 ISSN: 0267-835