A Special Seminar Presentation
Guoan Zheng, Ph.D.
(BIOMEDICAL ENGINEERING FACULTY CANDIDATE)
CALIFORNIA INSTITUTE OF TECHNOLOGY
FRIDAY, FEBRUARY 22, 2013
10:30-11:30 A.M.
UTEB 150 with video broadcast to UCHC, Room E2036
High-throughput gigapixel imaging and the opportunities it opens up
Microscopy has driven discoveries in biology for many centuries. However, a long-standing problem
remains -- one can either choose to view a small area of the sample in high-resolution or view a large area in
low-resolution. In this talk, I will present a solution that eliminates this tradeoff, allowing us to have the best
of both worlds. Our current prototype, readily implemented using a conventional microscope, is capable of
providing a numerical aperture of 0.5, a field-of-view of 120 mm^2, and a resolution-invariant depth-offocus of ~0.3 mm. Without involving any mechanical scanning, gigapixel images can be obtained in a
simple, robust, and cost-effective manner. I will demonstrate the applications of our prototype for digital
pathology, hematology, immunohistochemistry, and discuss the future opportunities it opens up. In
summary, this innovation may pave the way for a turnkey solution that enables high-throughput imaging for
the broad biomedical community.
Biographical Sketch
Guoan Zheng recently received his Ph.D. in Electrical Engineering from Caltech. His expertise is in
biomedical optics, computational imaging and lab-on-a-chip devices. His current research interest is to
develop novel and cost-effective high-throughput imaging technologies for various biomedical applications.
Dr. Zheng was the recipient of the Lemelson-MIT Caltech student prize in 2011. He was listed as “Ones to
Watch” by Photonics Spectra for his development of chip-scale imaging solutions. In 2010, he also led a
team of students to win the grand prize of the Idea-to-Product global competition. Prior to Caltech, he
obtained his B.S. from Zhejiang University, China, in 2007 and got the Microsoft fellowship from Microsoft
Research Asia in 2006