NB: Submission of an abstract and presentation at the Update on Cardiopulmonary Bypass Meeting does not
preclude you from submitting and presenting at the SCA, IARS or ASA Annual Meetings.
Instructions for Submitting Abstracts
1. Only abstracts submitted on the proper form will be considered.
2. Please use the format shown on the enclosed example (see page 2 of this document).
3. Font size smaller than 10 point will not be accepted.
4. All abstracts must be received by February 15, 2008.
5. All images need to be attached as a separate JPEG File.
6. Ensure that the Disclosure Form is completed and returned with abstract. (Only Presenting Author needs to complete this form)
7. Complete application below.
8. Create a blinded copy on page 4.
A. Copy only the Title and Abstract into their respective boxes.
B. Leave the Author(s) and Affiliation lines blank
9. Save this document.
10. E-mail the file to sca@societyhq.com Subject line should read: Abstract Submission – Presenting Authors Last
Name, i.e. – “Abstract Submission – Smith”. If your abstract contains any images, please include it as a separate
attachment to your email. Please make sure all figures, images, etc. are black and white.
11. These documents will be processed electronically. The blinded copy on Page 4 will be submitted to the judges. If your
document does not strictly follow the proper format it will not be processed.
12. If you have not received an email receipt confirmation within two (2) working days, please notify the SCA
Administrative Office at sca@societyhq.com, or Tel: 804-282-0084.
Abstract Submission Application
1. Title of Abstract:
2. Name of Author(s) and Institution. Include specialty preference and title(s) of each author. Presenting author should be
listed as (a). (Additional Authors may be listed on the last page, annotated Additional Authors)
a.
b.
c.
d.
3. Complete name and address of where correspondence should be sent:
Address:
Phone:
Fax:
Email:
4. If human subjects were used, do you agree or disagree with the following statement:
"My study satisfies the requirements of my institution or organization regarding the use of human subjects in scientific
research."
___ Agree
___ Disagree (mark your choice with an X)
Presentation type: All accepted abstracts will be presented as posters.
Duration of Cooling During Pediatric Cardiac Surgery Influences Cerebral Metabolism in Infant
Author(s): WJ Greeley, FH Kern, SR Schulman, B. Baldwin, RM Ungerleider
Affiliation: Harvard School of Medicine, Boston, MA
Introduction: Recent clinical studies during pediatric cardiac surgery have demonstrated that rapid cooling negatively
influences neuropsychologic outcome. (1, 2) In these studies, failure of hypothermia to adequately suppress cerebral
metabolism (CMR02) prior to deep hypothermia circulatory arrest (DHCA) was speculated to be the mechanism for injury.
Other experimental studies have suggested that the brain cools unevenly during cardiopulmonary bypass (CPB). (3) We
therefore, hypothesized that a longer duration of cooling would enhance more homogeneous brain cooling and promote
suppression of CMR02 prior to DHCA, and improve recovery of CMR02 after CPB.
Methods: After Institutional Review Board approval and informed consent, 60 neonates and infants undergoing cardiac
surgery with CPB and deep hypothermic circulatory arrest (DHCA) were randomized to one of two groups. Group A (n=30)
were exposed to prolonged CPB cooling of 20 min prior to DHCA, and compared to a cohort group (B) of another 30
patients undergoing standardized cooling to a nasopharyngeal temperature of 18°C and then arrested, where a shorter
duration of cooling is customary. Anesthetic management consisted of midazolam (75 mcg/kg load; and 0.75 mcg/kg/min
infusion), fentanyl (25 mcg/kg; and 1 mcg/kg/hr infusion) and pancuronium as required for neuromuscular blockade.
Nonpulsatile CPB pump flow with a membrane oxygenator was maintained at the rate of 150 ml/kg/min during cooling and
rewarming, and alpha-stat blood gas management was used. Cerebral blood flow (CBF), CMR02, and cerebral oxygen
extraction (A-V02) were measured before, during and after CPB. Intragroup data were analyzed using ANOVA for repeated
measurements and intergroup data were analyzed using unpaired T-tests, with significance assumed at the P<0.05 level.
Results: There was no intergroup difference with respect to age, congenital heart lesion, surgical procedure, or starting
hematocrit. Duration of cooling was significantly longer in Group A vs Group B (20.2±1.9 vs 11.6±2.0 min. respectively;
p<0.01). CMR02 and A-V02 difference were significantly lower in Group A compared to B after cooling (Table). Despite
greater CMR02 suppression in A, the recovery of CMRO2 after DHCA was not significantly different from Group B (Table).
Discussion: We conclude that increasing the duration of CPB cooling to 20 minutes prior to DHCA in infants optimizes
cerebral metabolic suppression. We speculate that increasing the duration of cooling promotes more homogeneous cooling of
the brain and recommend its application during cardiac surgery. However, despite the enhanced metabolic suppression due to
prolonged cooling, the recovery of CMR02 after DHCA is still abnormal, suggesting that hypothermic protection with
enhanced cooling may still be insufficient as a sole protective measure when DHCA is used.
TABLE I
CMRO2 I
II
III
A
1.2±0.40 0.08±0.04* 0.52±0.25#
B
1.2±0.33 0.19±0.10
0.65±0.34#
A-V 02
A
6.0±1.4
0.8±0.30*
4.4±1.4#
B
5.7±1.3
1.7±0.50
5.0±2.0
02Ext
A
40%±21 11%±5*
37%±15
B
45%±13 19%±6
39%±18
A=Prolonged cooling group; B=Control group; I=Baseline, warm; II=Cold, CPB; III=Rewarmed, Post-CPB;
CMR02=Cerebral metabolic rate, oxygen (ml/100gm/min); A-V 02=Cerebral AV 02 difference; 02 Ext=Cerebral oxygen
extraction ratio (%). Mean values ±S.D.; *p<0.05, grp A vs B; #p<0.05, stage III vs I.
Refs:
1. Bellinger D. et al., Pediatrics 1989
2. Greeley W.J. et al., J Thorac Cardiovsc Surg, 1991
3. Hindman, B.J. et al., Anesthesiology, 1992
TITLE:
AUTHOR(S):
AFFILIATION(S):
ABSTRACT BODY:
TITLE:
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AFFILIATION: <BLINDED COPY LEAVE BLANK>
ABSTRACT BODY
Disclosure of Relevant Financial Relationships
(Only Presenting Author needs to complete this form)
SCA 13th Annual Update on Cardiopulmonary Bypass Meeting
March 9-14, 2008 • Whistler, British Columbia, Canada
Name:
Content of Activity: Abstract Presentation (Poster)
Date of Activity: March 9-14, 2008
First: List the names of proprietary entities producing health care goods and services, with the exception
of non-profit or government organizations and non-health care related companies with which you or
your spouse/partner have, or have had, a relevant financial relationship within the past 12 months. For
this purpose we consider the relevant financial relationships of your spouse or partner that you are aware
of to be yours.
Second: Describe what you or your spouse/partner received (ex: salary, honorarium etc).
SCA does NOT want to know how much you received.
Third: Describe your role.
Nature of Relevant Financial Relationship
(Include all those that apply)
Commercial Interest
What was received
For What Role?
Honorarium
Speaker
Example: Company ‘X’
I do not have any relevant financial relationships with any commercial interests.
Signature
Date
Example terminology
What was received: Salary, royalty,
intellectual property rights, consulting
fee, honoraria, ownership interest (e.g.,
stocks, stock options or other ownership
interest, excluding diversified mutual
funds), or other financial benefit.
Role(s): Employment, management
position, independent contractor
(including contracted research),
consulting, speaking and teaching,
membership on advisory committees or
review panels, board membership, and
‘other activities (please specify).
Glossary of Terms
Commercial Interest
The ACCME defines a “commercial interest” as any proprietary entity producing health care
goods or services, with the exemption of non-profit or government organizations and non-health
care related companies.
Financial relationships
Financial relationships are those relationships in which the individual benefits by receiving a
salary, royalty, intellectual property rights, consulting fee, honoraria, ownership interest (e.g.,
stocks, stock options or other ownership interest, excluding diversified mutual funds), or other
financial benefit. Financial benefits are usually associated with roles such as employment,
management position, independent contractor (including contracted research), consulting, speaking
and teaching, membership on advisory committees or review panels, board membership, and other
activities from which remuneration is received, or expected. ACCME considers relationships of
the person involved in the CME activity to include financial relationships of a spouse or partner.
Relevant financial relationships
ACCME focuses on financial relationships with commercial interests in the 12-month period
preceding the time that the individual is being asked to assume a role controlling content of the
CME activity. ACCME has not set a minimal dollar amount for relationships to be significant.
Inherent in any amount is the incentive to maintain or increase the value of the relationship. The
ACCME defines “’relevant’ financial relationships” as financial relationships in any amount
occurring within the past 12 months that create a conflict of interest.
Conflict of Interest
Circumstances create a conflict of interest when an individual has an opportunity to affect CME
content about products or services of a commercial interest with which he/she has a financial
relationship.
CME REQUIREMENTS
The Accreditation Council for Continuing Medical Education (ACCME) accredits SCA. As such, we
have made the choice to meet the ACCME’s expectations for our practice of continuing medical
education. Our accreditation is important to us. We look forward to working together to provide CME at
the highest standard.
SCA has implemented a process where everyone who is in a position to control the content of an
education activity has disclosed to us all relevant financial relationships with any commercial interest. In
addition, should it be determined that a conflict of interest exists as a result of a financial relationship
you may have, this will need to be resolved prior to the activity. This information is necessary in order
for us to be able to move to the next steps in planning this CME activity. If you refuse to disclose
relevant financial relationships, you will be disqualified from being a part of the CME activity.
The Commercial Support Standards also require that you presentation is free of commercial bias and
that any information regarding commercial products/services be based on scientific methods generally
accepted by the medical community. When discussing therapeutic options, it is our preference that you
use only generic names. If it is necessary to use a trade name, then those of several companies must be
used. Further, should your presentation include discussion of any unlabeled/investigational use of a
commercial product, you are required to disclose this to the participants. Should you determine that you
cannot comply with these requirements or any of the provisions, please contact the SCA Administrative
Office as soon as possible.
It is the Society’s policy to conduct post-activity evaluations. These evaluations ask participants to
indicate the appropriateness of presentations to their specific practices, if the presentations satisfied the
stated objectives, if they were satisfied with the faculty presentations and if there was any evidence of
commercial bias. The results of these evaluations are used to plan future CME activities and are shared
with the faculty.
Once again thank you for your willingness to participate in this event. We have worked hard to develop
a program which will meet the expressed needs of our expected participants, who we anticipate will
come from the US, Canada and overseas. We have specifically promoted this educational activity to the
SCA, Canadian Society of Clinical Perfusionists and the American Society of Extacorporeal Technology
memberships.
A) Generic and Trade Names – Presentations must give a balanced view of therapeutic options.
Presenter’s use of general names will contribute to this impartiality. If trade names are used,
those of several companies should be used rather than only that of a single supporting company.
B) Unlabeled Uses of Products – When an unlabeled use of a commercial product, or an
investigational use not yet approved for any purpose is discussed during an educational activity,
the presenter is required to disclose that the product is not labeled for the use under discussion or
that the product is still investigational.
My presentation will comply with sections A-B above.
SIGNATURE:________________________________________
DATE:____________________
PLEASE RETURN TO THE SCA ADMINISTRATIVE OFFICE WITH YOUR
ABSTRACT SUBMISSION
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