Drug Information Sheet("Kusuri-no-Shiori") Injection Revised: 08/2012 The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse effects (risks) as well as efficacies (benefits). It is important to minimize adverse effects and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment. Brand name:KYTRIL Injection 1 mg Active ingredient:Granisetron hydrochloride Dosage form:injection Print on wrapping: Effects of this medicine This medicine suppresses nausea and vomiting caused by anti-cancer drugs and radiation therapy by inhibiting antagonistically a bond with serotonin and a receptor. It is usually used to treat digestive symptoms (nausea and vomiting) caused by anti-cancer drugs and radiation therapy. Before using this medicine, be sure to tell your doctor and pharmacist ・If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have: constipation, abdominal pain, abdominal bloating. ・If you are pregnant or breastfeeding. ・If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) ・Your dosing schedule prescribed by your doctor is<< to be written by a healthcare professional>> ・In general, inject intravenously or with drip infusion once a day. Depending on the symptom, it may be injected with drip infusion twice a day. ・The treatment period with this medicine depends on your response to the treatment. Precautions while taking this medicine Possible adverse effects of this medicine The most commonly reported adverse reactions include headache and fever. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse effects indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. ・chill, cold sweat, numbness of hands and feet, lightheadedness, dyspnea, feeling of tight chest, rash, urticaria, redness of skin, itch, edema, falling in blood pressure [shock, anaphylactoid symptoms] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information For healthcare professional use only / / For further information, talk to your doctor or pharmacist. 1/4 Drug Information Sheet("Kusuri-no-Shiori") Injection Revised: 08/2012 The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse effects (risks) as well as efficacies (benefits). It is important to minimize adverse effects and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment. Brand name:KYTRIL Injection 3 mg Active ingredient:Granisetron hydrochloride Dosage form:injection Print on wrapping: Effects of this medicine This medicine suppresses nausea and vomiting caused by anti-cancer drugs and radiation therapy by inhibiting antagonistically a bond with serotonin and a receptor. It is usually used to treat digestive symptoms (nausea and vomiting) caused by anti-cancer drugs and radiation therapy. Before using this medicine, be sure to tell your doctor and pharmacist ・If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have: constipation, abdominal pain, abdominal bloating. ・If you are pregnant or breastfeeding. ・If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) ・Your dosing schedule prescribed by your doctor is<< to be written by a healthcare professional>> ・In general, inject intravenously or with drip infusion once a day. Depending on the symptom, it may be injected with drip infusion twice a day. ・The treatment period with this medicine depends on your response to the treatment. Precautions while taking this medicine Possible adverse effects of this medicine The most commonly reported adverse reactions include headache and fever. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse effects indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. ・chill, cold sweat, numbness of hands and feet, lightheadedness, dyspnea, feeling of tight chest, rash, urticaria, redness of skin, itch, edema, falling in blood pressure [shock, anaphylactoid symptoms] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information For healthcare professional use only / / For further information, talk to your doctor or pharmacist. 2/4 Drug Information Sheet("Kusuri-no-Shiori") Injection Revised: 08/2012 The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse effects (risks) as well as efficacies (benefits). It is important to minimize adverse effects and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment. Brand name:KYTRIL Intravenous Bag 3 mg/50mL Active ingredient:Granisetron hydrochloride Dosage form:injection Print on wrapping: Effects of this medicine This medicine suppresses nausea and vomiting caused by anti-cancer drugs and radiation therapy by inhibiting antagonistically a bond with serotonin and a receptor. It is usually used to treat digestive symptoms (nausea and vomiting) caused by anti-cancer drugs and radiation therapy. Before using this medicine, be sure to tell your doctor and pharmacist ・If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have: circulatory dysfunction such as heart, renal disorder, constipation, abdominal pain, abdominal bloating. ・If you are pregnant or breastfeeding. ・If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) ・Your dosing schedule prescribed by your doctor is<< to be written by a healthcare professional>> ・Usually, inject with intravenous infusion once a day. Depending on the symptom, it may be injected with intravenous infusion twice a day. ・The treatment period with this medicine depends on your response to the treatment. Precautions while taking this medicine Possible adverse effects of this medicine The most commonly reported adverse reactions include headache and fever. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse effects indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. ・chill, cold sweat, numbness of hands and feet, lightheadedness, dyspnea, feeling of tight chest, rash, urticaria, redness of skin, itch, edema, falling in blood pressure [shock, anaphylactoid symptoms] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information For healthcare professional use only / / For further information, talk to your doctor or pharmacist. 3/4 Drug Information Sheet("Kusuri-no-Shiori") Injection Revised: 08/2012 The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse effects (risks) as well as efficacies (benefits). It is important to minimize adverse effects and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment. Brand name:KYTRIL Intravenous Bag 3 mg/100mL Active ingredient:Granisetron hydrochloride Dosage form:injection Print on wrapping: Effects of this medicine This medicine suppresses nausea and vomiting caused by anti-cancer drugs and radiation therapy by inhibiting antagonistically a bond with serotonin and a receptor. It is usually used to treat digestive symptoms (nausea and vomiting) caused by anti-cancer drugs and radiation therapy. Before using this medicine, be sure to tell your doctor and pharmacist ・If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have: circulatory dysfunction such as heart, renal disorder, constipation, abdominal pain, abdominal bloating. ・If you are pregnant or breastfeeding. ・If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) ・Your dosing schedule prescribed by your doctor is<< to be written by a healthcare professional>> ・In general, inject with intravenous infusion once a day. Depending on the symptom, it may be injected with intravenous infusion twice a day. ・The treatment period with this medicine depends on your response to the treatment. Precautions while taking this medicine Possible adverse effects of this medicine The most commonly reported adverse reactions include headache and fever. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse effects indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. ・chill, cold sweat, numbness of hands and feet, lightheadedness, dyspnea, feeling of tight chest, rash, urticaria, redness of skin, itch, edema, falling in blood pressure [shock, anaphylactoid symptoms] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information For healthcare professional use only / / For further information, talk to your doctor or pharmacist. 4/4