Chapter 10: Genomes and Proteomes
When available, the links under the Suggested Readings section will take you to websites
that either provide free electronic full-text versions of these references, or links to online
abstracts. All of these abstracts are themselves free. Many of the abstract sites contain
links to online full-text versions of the references; some of these full-text versions are
free, while others require personal or institutional subscriptions. None of the sites that can
be accessed through the links below are affiliated with McGraw-Hill Publishers.
Historical Papers on the Origins of the Human Genome Project
Suggested Readings:
 Cantor, RR. 1990. Orchestrating the Human Genome Project. Science. 248(4951):
49-51. [full text link]
This paper describes the early organization structure for the Human Genome
Project.

Collins. F and D. Galas. 1993. A New Five-Year Plan for the Human Genome
Project. Science 262:5130-5143 [Full text link]
This paper outlines some of the revised goals and technologies of the Human
Genome Project a few years after the project began.

Watson, JD. 1990. The Human Genome Project: Past, Present and Future.
Science. 248(4951): 44-49 [full-text link]
An early paper on how the Human Genome Project was developed and some of
the initial goals of the program.
Historical and Contemporary Papers on the Technologies of the Human Genome
Project
Suggested Readings:

Chan EY. 2005 Advances in Sequencing Technology. Mutat Res. 573(1-2):13-40
[Entrez-PubMed link]
Examines some of the changes in DNA sequencing brought on by technology
developed from the Human Genome Project.
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
Lander, E. S. (1999). Array of Hope. Nature Genetics 21:1-4. . [Entrez-PubMed
link]
This entry describes the development of DNA array technology and its
applications

Olsen, Maynard. 2001. Clone by Clone by Clone. Nature. 490:816-818.
Examines the approaches by which the human genome was sequenced and
questions whether the approach is appropriate for other organisms.

Pevzner. PA. 2001. Assembling Puzzles from Preassembled Blocks. Genome
Research 11(9): 1-2. [full text link]
Explains the operation of the software (GigAssembler) in an DNA genome
sequence assembler.
Historical and Contemporary Papers on the Conclusions Drawn from the Human
Genome Project
Suggested Readings:

Lander ES. et al. 2001.Initial Sequencing and Analysis of the Human Genome.
Nature. 409:860-921. [Nature.com abstract]
This issue contains the draft sequence generated by the public International
Human Genome Sequencing Consortium.

Venter, J,C. et al. The Sequence of the Human Genome. Science. 291:1304-1351.
[Entrez-PubMed link]
This issue contains the draft sequence generated by Celera.

Ideker, T., Galitski, T., and Hood, L. 2001. A New Approach to Decoding Life:
Systems Biology. Annual Review of Genomics and Human Genetics 2:343-72.
[Entrez-PubMed]
This paper indicates how the systems biology emerged from the developments of
the Human Genome Project.
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Links to Publicly Available Sequence Data and other Genomic Information
Websites:

University of Santa Cruz Genome Resources
http://genome.ucsc.edu/
A bioinformatics site that contains access to a number of genomes, including
humans. Follow the link “Genome Browser” to begin your search.

EBI/Sanger Center
http://www.ensembl.org
An easy to navigate site that provides links to a large number of genomes
currently being studied. Supports Blast searches.

NCBI Human Genome Resources
http://www.ncbi.nlm.nih.gov/genome/guide/
This site contains some useful tools for genomic research. From the homepage it
is possible to examine all of the information on a single human chromosome.
Additional useful links on this page include those for electronic PCR and a
gateway into the Online Mendelian Inheritance in Man (OMIM).

DOE Joint Genome Institute
http://genome.jgi-psf.org/
Contains links to projects currently in progress by the labs associated with the
DOE genome projects, as well as gateways to sequence information on a wide
range of genomes.

NHDGRI
http://www.genome.gov/
A NIH sponsored site that provides genomic information and links to disease and
human health.
Historical and Contemporary Papers on the Ethical, Social, and Legal Implications of
the Human Genome Project
Suggested Readings:

Anderlik, MR and MA Rothstein. 2001. Privacy and Confidentiality of Genetic
Information: What Rules for the New Science? Annu Rev Genomics Hum Genet.
2:401-433. [Entrez-PubMed link]
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A review that examines the ethical and legal issues associated with the release of
genetic information. The references cites section of this paper is a useful
bibliography of research done in this field.

Collins, FS, ED Green, AE Guttmacher, et al. 2003. A Vision for the Future of
Genomics Research. Nature. 422:835-837. [Full text link]
The authors of this paper, which includes members of the US National Genome
Research Institute, examine how the information obtained from the Human
Genome Project can be used responsibly.

Singer. PA and AS Daar. 2001. Harnessing Genomics and Biotechnology to
Improve Global Health Equity. Science 294:87-89.
The article examines the potential for genomics to benefit health care systems.

Spinello, RA. 2004. Property Rights in Genetic Information. Ethics Inf Technol.
6(1):29-42 [Entrez-PubMed link]
This paper examines ownership rights of an individual’s genetic information.

Winickoff, DE. 2003. Governing Population Genomics: Law, Bioethics and
Biopolitics in Three Case Studies. Jurimetrics. 43(2):187-228. [Entrez-Pubmed
link]
This paper examines some of the ethical debates associated with population
genomic studies conducted as part of the Human Genome project and the
Icelandic government.
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