时玉舫教授加盟苏州大学，欢迎有志于转化医学研究的同学报考
时玉舫教授, 博士生导师，于 2014 年 7 月加盟苏州大学， 成立转化医学研究院。 他
是中央组织部“千人计划”首批入选者，国家特聘专家，国家 973 研究计划总体组成员，国
家 973 重大研究计划生殖与发育专项协调人，国家 973 重大研究计划项目首席科学家；国际
细胞治疗学会间充质干细胞治疗分会专家组成员；于 2008 年至 2014 年担任中国科学院上海
生命科学研究院/上海交通大学医学院健康科学研究所所长。于 2003 年任美国新泽西医科齿
科大学-罗伯特• 伍德• 约翰逊医学院终身正教授，为该大学特聘大学教授（University
Professor）
。目前主要致力于（1）间充质干细胞免疫生物学与疾病之间的关系；
（2）肿瘤基
质干细胞和肿瘤免疫；
（3）T 细胞亚群的活化诱导细胞凋亡等三个方面的研究。时玉舫研究
员在细胞凋亡方面做了开创性研究，率先提出 AICD 的概念（Nature. 1989）；发现 c-myc 对
细胞凋亡的调节作用（Science. 1992）
；证实 Fas 介导的淋巴细胞凋亡与应激反应或鸦片所致
免疫抑制的关系（Nature. 1999）
；率先发现炎症在癌症发生过程中具有重要作用（Cancer Cell.
2006）
；证明了 CD4+ T 细胞在哮喘中的决定性作用（Nature Medicine. 2006）
；首次证明了不
同 T 细胞亚群具有不同的细胞凋亡途径（Immunity. 2006）
。所带领的团队近年来在国际上领
衔了干细胞与免疫之间相互关系的研究，揭示炎症因子诱导干细胞产生细胞生长因子以及干
细胞成脂成骨分化平衡中重要作用及机制（Stem Cells. 2010; Stem Cells. 2014）
；发现了间充
质干细胞免疫调控的体内作用机制（Cell Stem Cell. 2008, The Journal of Immunology. 2010, The
Journal of Biological Chemistry. 2013）
；系统分析并明确不同物种间充质干细胞介导免疫抑制
作用核心分子的差异性（Stem Cells. 2009，Cell Death & Differentiation. 2014）；从多角度、多
层次分析明确间充质干细胞免疫调节作用的可塑性，并证明这种特性对间充质干细胞介导的
免疫紊乱性疾病治疗的影响（Cell Death & Differentiation. 2012, The Journal of Immunology.
2014, Cell Death & Disease. 2014, Cell Death & Differentiation. 2014, Nature Immunology. 2014）
；
与此同时，以免疫与间充质干细胞交互作用为视角，解释了肿瘤基质干细胞形成机制及作用
特点（Cell Stem Cell. 2012, Oncogene. 2013），并以修正肿瘤部位基质环境为出发点，优化肿
瘤治疗策略（Oncogene. 2013）
。时玉舫研究员以创新性视野和原创性研究探寻并揭示间充
质干细胞免疫调节作用的特点，提出间充质干细胞免疫调节作用可塑性的概念，对理解和指
导干细胞在疾病致病机制中的作用及其临床应用具有里程碑式的指导意义。迄今为止，时玉
舫研究员承担多项科技部、卫生部、基金委、中科院、上海市等多项重大重点研究课题及国
际合作项目，已发表 SCI 收录的研究论文 160 余篇，包括国际知名学术期刊 Nature、Science、
Immunity 、 NatureImmunology 、 Nature Medicine 、 Cell Stem Cell 、 Journal of Experimental
Medicine、The Journal of Immunology、Cancer Research、PNAS、Stem Cells 等，并在国际顶尖
杂志如 Nature Immunology、Cell Stem Cell、Trends in Immunology 上发表评述和综述，所发表
文章的他引次数近 10,800 次。时玉舫研究员先后获得中国侨界贡献奖创新人才奖等多项奖
励支持。
时玉舫教授，1998 年至 2002 年，任 Journal of Immunology 副主编；2009 年成为美国
德克萨斯州干细胞研究和应用委员会委员；同年被 Oncogene 杂志邀请做编审（Receiving
Editor）
；2013 年，又出任 Cell Death and Disease 杂志主编（Editor-in-Chief）
。 同时他还任
Cell & Bioscience, American Journal of Translational Research, Journal of Biomedicine and
Biotechnology, Journal of Biological Chemistry, Journal of Molecular and Cell Biology, Stem Cells
and Translational Medicine, Stem Cell Research and Therapy and Cellular and Molecular
Immunology 的编委。
受教育经历
1988-1992，加拿大阿尔伯塔大学，动物学系，博士，导师：Dr. Douglas R. Green；
1985-1988，加拿大阿尔伯塔大学，动物学系，硕士，导师：Dr. Jerome L. Mahrt；
1977/09-1982/07，山东农业大学，畜牧兽医系，学士；
研究工作经历
2008起 中国科学院上海生命科学院/上海交通大学医学院，健康科学研究所，研究员/所长
2004起 美国新泽西医科和牙科大学-罗伯特•伍德•约翰逊医学院，药物学系，教授
2003起 美国新泽西医科和牙科大学-罗伯特•伍德•约翰逊医学院，分子遗传学、微生物学和
免疫学系，终身教授
2001起，美国新泽西癌症研究所，研究员
2001-2003 美国新泽西医科和牙科大学-罗伯特•伍德•约翰逊医学院分子遗传学、微生物学和
免疫学系，终身副教授
1999-2001 美国乔治•华盛顿大学免疫学系，终身副教授
1999-2001 美国红十字协会Holland医学生物研究所，免疫学部，Scientist II终身副教授
1999-2001 美国乔治•华盛顿大学，免疫学系，助理教授
1996-1999 美国乔治•华盛顿大学，微生物学和免疫学系，助理教授
1995-1999 美国红十字协会Holland医学生物研究所，免疫学部，Scientist I助理教授
1992-1995 加拿大多伦多大学，免疫学系，博士后
1986-1989 加拿大阿尔伯塔大学，动物学系，助教
1982/01-1985/09 山东农业大学，畜牧兽医系，助教
文章列表：
1. Wang Y, Chen Xiaodong, Cao Wei, Shi Y. Plasticity of mesenchymal stem cells in
immunomodulation: pathological and therapeutic implications. Nature
Immunology. 2014, In press.
2. Han X, Yang Q, Lin L, Xu C, Zheng C, Chen X, Han Y, Li M, Cao W, Cao K, Chen
Q, Xu G, Zhang Y, Zhang J, Schneider RJ, Qian Y, Wang Y, Brewer G, Shi Y.
Interleukin-17 enhances immunosuppression by mesenchymal stem cells. Cell
Death Differ. 2014 Jul 18. doi: 10.1038/cdd.2014.85.
3. Yin S, Yang J, Lin B, Deng W, Zhang Y, Yi X, Shi Y, Tao Y, Cai J, Wu CI, Zhao G,
Hurst LD, Zhang J, Hu L, Kong X. Exome sequencing identifies frequent mutation
of MLL2 in non-small cell lung carcinoma from Chinese patients. Sci Rep. 2014
Aug 12;4:6036. doi: 10.1038/srep06036.
4. Zhang M, Zhou H, Zheng C, Xiao J, Zuo E, Liu W, Xie D, Shi Y, Wu C, Wang H, Li
D, Li J. The roles of testicular c-kit positive cells in de novo morphogenesis of
testis. Sci Rep. 2014 Aug 4;4:5936.
5. Zhu K, Zhang N, Guo N, Yang J, Wang J, Yang C, Yang C, Zhu L, Xu C, Deng Q,
Zhu R, Wang H, Chen X, Shi Y, Li Y, Leng Q.
SSC(high)CD11b(high)Ly-6C(high)Ly-6G(low) myeloid cells curtail CD4 T cell
response by inducible nitric oxide synthase in murine hepatitis. Int J Biochem Cell
Biol. 2014 Sep;54:89-97.
6. Liu S, Sun X, Wang M, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen
X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y, Siebenlist U,
Zhang X. A microRNA 221- and 222-Mediated Feedback Loop Maintains
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14.
Constitutive Activation of NFκB and STAT3 in Colorectal Cancer Cells.
Gastroenterology. 2014 Oct;147(4):847-859.e11.
Ke F, Zhang L, Liu Z, Liu J, Yan S, Xu Z, Bai J, Zhu H, Lou F, Wang H, Shi Y,
Jiang Y, Su B, Wang H. Autocrine Interleukin-6 Drives Skin-Derived Mesenchymal
Stem Cell Trafficking via Regulating Voltage-Gated Ca(2+) Channels. Stem Cells.
2014 Oct;32(10):2799-810.
Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D,
Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH,
Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C,
Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel
NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson
VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD,
El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR,
Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B,
Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ,
Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F,
Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S,
Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T,
Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H,
Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC,
Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL,
Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A,
Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B,
Melino G, Kroemer G. Essential versus accessory aspects of cell death:
recommendations of the NCCD 2015. Cell Death Differ. 2014 Sep 19. doi:
10.1038/cdd.2014.137.
Shi Y. The 1000th publication features protection of normal cells during
chemotherapy: a land mark for Cell Death & Disease. Cell Death Dis. 2014
Feb 13;5:e1062.
Cao G, Yang Q, Zhang S, Xu C, Roberts, AI, Wang Y, Shi Y. Mesenchymal stem
cells prevent restraint stress-induced lymphocyte depletion via interleukin-4. Brain
Behav Immun. 2014, ay;38:125-32.
Ling W, Zhang J, Yuan Z, Ren G, Zhang L, Chen X, Rabson AB, Roberts AI,
Wang Y, Shi Y. Mesenchymal Stem Cells Employ IDO to Regulate Immunity in
Tumor Microenvironment. Cancer Research. 2014, Mar 1;74(5):1576-87.
Chen Q, Shou P, Zhang L, Xu C, Zheng C, Han Y, Li W, Huang Y, Zhang X, Shao
C, Roberts AI, Rabson AB, Ren G, Zhang Y, Wang Y, Denhardt DT, Shi Y. An
Osteopontin-Integrin interaction plays a critical role in directing adipogenesis and
osteogenesis by mesenchymal stem cells. Stem Cells. 2014 Feb;32(2):327-37.
Ma S, Xie N, Li W, Yuan B, Shi Y, Wang Y. Immunobiology of mesenchymal stem
cells. Cell Death Differ. 2014 Feb;21(2):216-25.
Zhang Y, Cai W, Huang Q, Gu Y, Shi Y, Huang J, Zhao F, Liu Q, Wei X, Jin M, Wu
C, Xie Q, Zhang Y, Wan B, Zhang Y. Mesenchymal stem cells alleviate
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bacteria-induced liver injury in mice by inducing regulatory dendritic cells.
Hepatology. 2014 Feb;59(2):671-82.
Chen X, Gan Y, Li W, Su J, Zhang Y, Huang Y, Roberts AI, Han Y, Li J, Wang Y,
Shi Y. The interaction between mesenchymal stem cells and steroids during
inflammation. Cell Death Disease. 2014 Jan 23; 5:e1009.
Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi
Y, Iwakura Y, Qian Y. Alterations in the Microbiota Drive Interleukin-17C
Production from Intestinal Epithelial Cells to Promote Tumorigenesis. Immunity.
2014, 40:140-152.
Xu C, Yu P, Han X, Du L, Gan J, Wang Y, Shi Y. TGF-β Promotes Immune
Responses in the Presence of Mesenchymal Stem Cells. J Immunol. 2014,
192:103-109.
Ren G, Liu Y, Zhao X, Zhang J, Zheng B, Yuag Z, Zhang L, Tischfield J, Shao C,
Shi Y. Tumor resident mesenchymal stromal cells endow naïve stromal cells with
tumor-promoting properties. Oncogene. 2014 Jul 24;33(30):4016-20.
Su J, Chen X, Huang Y, Li W, Li J, Cao K, Cao G, Zhang L, Li F, Roberts AI, Kang
H, Yu P, Ren G, Ji W, Wang Y, Shi Y. Phylogenetic distinction of iNOS and IDO
function in mesenchymal stem cell-mediated immunosuppression in mammalian
species. Cell Death Differ. 2014 Mar;21(3):388-96.
Xu C, Lin L, Cao G, Chen Q, Shou P, Huang Y, Han Y, Wang Y, Shi Y.
Interferon-α-secreting mesenchymal stem cells exert potent antitumor effect in
vivo. Oncogene. 2013 Nov 4. doi: 10.1038/onc.2013.458.
Huang Y, Yu P, Li W, Ren G, Roberts, AI, Cao W, Zhang X, Su J, Chen X, Chen Q,
Shou P, Xu C, Du L, Lin L, Zhang L, Xie N, Wang Y and Shi Y. p53 regulates
mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment
through immune modulation. Oncogene. 2014 Jul 17;33(29):3830-8.
Lang JY, Shi Y, Chin YE. Reprogramming cancer cells: back to the future.
Oncogene. 2013, 32(18):2247-2248.
Hou J, Han Z, Jing Y, Yang X, Zhang S, Sun K, Hao C, Meng Y, Yu F, Liu X, Shi Y,
Wu M, Zhang L, Wei L. Autophagy prevents irradiation injury and maintains
stemness through decreasing ROS generation in mesenchymal stem cells. Cell
Death Disease. 2013, 4:e844.
Chen P, Zhang J, Zhan Y, Su J, Du Y, Xu G, Shi Y, Siebenlist U, Zhang X.
Established thymic epithelial progenitor/stem cell-like cell lines differentiate into
mature thymic epithelial cells and support T cell development. PLoS One. 2013,
8:e75222.
Zhang J, Liu C, Roberts AI, Xu G, REN G, Zhang L, Devadas S and Shi Y. A novel
subset of helper T cells promotes immune responses by secreting GM-CSF. Cell
Death Differ. 2013, 20:1731-1741.
Wu Q, Wang H, Zhao X, Shi Y, Jin M, Wan B, Xu H, Cheng Y, Ge H, Zhang Y.
Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor
that induces angiogenesis and migration in human colorectal carcinoma.
Oncogene. 2013 Dec 5;32(49):5541-50.
27. Yu B, He Z, You P, Han Q, Xiang D, Chen F, Wang M, Liu C, Lin X, Borjigin U, Zi
X, Li J, Zhu H, Li W, Han C, Wangensteen KJ, Shi Y, Hui L, Wang X, Hu Y.
Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors.
Cell Stem Cell. 2013, 13:328-340.
28. Liu B, Chen X, Wang Y, Shi Y. Curative effect of hepatic portal venous
administration of autologous bone marrow in AIDS patients with
decompensatedliver cirrhosis. Cell Death Disease 2013, 4:e739.
29. Phinney DG, Galipeau J, Krampera M, Martin I, Shi Y, Sensebe L. MSCs: science
and trials. Nature Medicine 2013, 19:812-812.
30. Wei X, Yang X, Han Z, Qu F, Shao L, Shi Y. Mesenchymal stem cells: a new trend
for cell therapy. Acta Pharmacologica Sinica. 2013, 34,747-754.
31. Xu C, Ren G, Cao G, Chen Q, Shou P, Zheng C, Du L, Han X, Jiang M, Yang Q,
Lin L, Wang G, Yu P, Zhang X, Cao W, Brewer G, Wang Y, Shi Y. MiR-155
regulates immune modulatory properties of mesenchymal stem cells by targeting
TAK1-binding protein 2. Journal of Biological Chemistry 2013, 288:11074-11079.
32. Krampera M, Galipeau J, Shi Y, Tarte K, Sensebe L. Immunological
characterization of multipotent mesenchymal stromal cells - The International
Society for Cellular Therapy (ISCT) working proposal. Cytotherapy. 2013,
15(9):1054-61.
33. Wu X, Chesoni S, Rondeau G, Tempesta C, Patel R, Charles S, Daginawala N,
Zucconi BE, Kishor A, Xu G, Shi Y, Li ML, Barreto PI, Welsh J, Wilson GM, Brewer
G. Combinatorial mRNA binding by AUF1 and Argonaute 2 controls decay of
selected target mRNAs. Nucleic Acids Research 2013, 41:2644-2658.
34. Yang X, Hou J, Han Z, Wang Y, Hao C, Wei L, Shi Y. One cell, multiple roles:
contribution of mesenchymal stem cells to tumor development in tumor
microenvironment. Cell & Bioscience 2013, 3:5-10.
35. Zeng A, Li Y, Wang C, Han X, Li G, Wang JY, Li D, Qin Y, Shi Y, Brewer G, Jing Q.
Heterochromatin protein 1 promotes self-renewal and triggers regenerative
proliferation in adult stem cells. The Journal of Cell Biology 2013, 201:409-425.
36. Liu Z, Jiang Y, Hou Y, Hu Y, Cao X, Tao Y, Xu C, Liu S, Wang S, Wang L, Shi Y,
Siebenlist U, Zhang X. The IκB family member Bcl-3 stabilizes c-Myc in colorectal
cancer. Journal of Molecular Cell Biology 2013, 5: 280-282.
37. Qu F, Gao H, Zhu S, Shi P, Zhang Y, Liu Y, Jallal B, Yao Y, Shi Y, Qian Y.
TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases
suppresses interleukin-17-induced NF-κB activation. Molecular and Cellular
Biology 2012, 32:3925-3937.
38. Ren G, Zhao X, Wang Y, Zhang X, Chen X, Xu C, Yuan Z, Roberts A, Zhang L,
Zheng B, Wen T, Han Y, Rabson A, Tischfield J, Shao C, Shi Y. CCR2-dependent
recruitment of macrophages by tumor-educated mesenchymal stromal cells
promotes tumor development and is mimicked by TNFα. Cell Stem Cell 2012,
11:812-824.
39. L’huillier A, Ren G, Shi Y, Zhang J. A two-hit model of autoimmunity: lymphopenia
and unresponsiveness to TGF-β signaling. Cellular & Molecular Immunology 2012,
9:369-370.
40. Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, Liang D, He D, Wang H, Liu W, Shi
Y, Harley JB, Shen N, Qian Y. The microRNA miR-23b suppresses
IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.
Nat Med 2012, 18:1077-1086.
41. Yao Y, Wang Y, Chen F, Huang Y, Zhu S, Leng Q, Wang H, Shi Y, Qian Y.
NLRC5 regulates MHC class I antigen presentation in host defense against
intracellular pathogens. Cell Res 2012, 22:836-847.
42. Li W, Ren G, Huang Y, Su J, Han Y, Li J, Chen X, Cao K, Chen Q, Shou P, Zhang
L, Yuan ZR, Roberts AI, Shi S, Le AD, Shi Y. Mesenchymal stem cells: a
double-edged sword in regulating immune responses. Cell Death Differ 2012,
19:1505-1513.
43. Han Z, Jing Y, Zhang S, Liu Y, Shi Y, Wei L. The role of immunosuppression of
mesenchymal stem cells in tissue repair and tumor growth. Cell & Bioscience
2012, 2:8.
44. Shi Y, Su J, Roberts AI, Shou P, Rabson AB, Ren G. How mesenchymal stem
cells interact with tissue immune responses. Trends in Immunology 2012,
33:136-143. (标注）
45. Sensebé L, Tarte K, Galipeau J, Krampera M, Martin I, Phinney DG, Shi Y.
Limited Acquisition of Chromosomal Aberrations in Human Adult Mesenchymal
Stromal Cells. Cell Stem Cell 2012, 10:9-10.
46. Shi Y, Wei L, Wang Y, Ren G. Stem Cells Deployed for Bone Repair Hijacked by
T Cells. Cell Stem Cell. 2012, 10:6-8.
47. Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV,
Dawson TM, Dawson VL, El-Deiry WS, Fulda S, Gottlieb E, Green DR,
Hengartner MO, Kepp O, Knight RA, Kumar S, Lipton SA, Lu X, Madeo F, Malorni
W, Mehlen P, Nunez G, Peter ME, Piacentini M, Rubinsztein DC, Shi Y, Simon HU,
Vandenabeele P, White E, Yuan J, Zhivotovsky B, Melino G, Kroemer G.
Molecular definitions of cell death subroutines: recommendations of the
Nomenclature Committee on Cell Death 2012. Cell Death and Differentiation 2012,
19:107-120.
48. Ren G, Chen X, Dong F, Li W, Ren X, Zhang Y, Shi Y. Concise review:
mesenchymal stem cells and rranslational medicine: emerging issues. Stem Cells
Transl Med. 2012, 1:51-58.
49. Han Z, Tian Z, Lv G, Zhang L, Jiang G, Sun K, Wang C, Bu X, Li R, Shi Y, Wu M,
Wei L. Immunosuppressive effect of bone marrow‐derived mesenchymal stem
cells in inflammatory microenvironment favours the growth of B16 melanoma cells.
J Cell Mol Med. 2011, 15:2343-2352.
50. Shi P, Zhu S, Lin Y, Liu Y, Liu Y, Chen Zn, Shi Y, Qian Y. Persistent Stimulation
with Interleukin-17 Desensitizes Cells Through SCFβ-TrCP-Mediated Degradation
of Act1. Sci Signal 2011, 4:ra73.
51. Song X, Zhu S, Shi P, Liu Y, Shi Y, Levin SD, Qian Y. IL-17RE is the functional
receptor for IL-17C and mediates mucosal immunity to infection with intestinal
pathogens. Nat Immunol 2011 Oct 12;12(12):1151-8.
52. Cao W, Yang Y, Wang Z, Liu A, Fang L, Wu F, Hong J, Shi Y, Leung S, Dong C,
Zhang JZ. Leukemia Inhibitory Factor Inhibits T Helper 17 Cell Differentiation and
Confers Treatment Effects of Neural Progenitor Cell Therapy in Autoimmune
Disease. Immunity 2011, 35:273-284.
53. Krause CD, Izotova LS, Ren G, Yuan ZR, Shi Y, Chen CC, Ron Y, Pestka S.
Efficient co-expression of bicistronic proteins in mesenchymal stem cells by
development and optimization of a multifunctional plasmid. Stem Cell Research &
Therapy 2011, 2:1-20.
54. Yamaza T, Ren G, Akiyama K, Chen C, Shi Y, Shi S. Mouse mandible contains
distinctive mesenchymal stem cells. Journal of Dental Research 2011,
90:317-324.
55. Ren G, Roberts AI, Shi Y. Adhesion molecules: key players in mesenchymal stem
cell-mediated immunosuppression. Cell Adhesion & Migration 2011, 5:20-22.
56. Zhu S, Pan W, Shi P, Gao H, Zhao F, Song X, Liu Y, Zhao L, Li X, Shi Y, Qian Y.
Modulation of experimental autoimmune encephalomyelitis through
TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med
2010, 207:2647-62.
57. Hu G, Ren G, Shi Y. The putative cannabinoid receptor GPR55 promotes cancer
cell proliferation. Oncogene 2010, 30:139-141.
58. Swaims AY, Khani F, Zhang Y, Roberts AI, Devadas S, Shi Y*, Rabson AB*.
Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+
T-cells. Blood. 2010 Oct 21;116(16):2994-3003. (*equal contribution)
59. Arriola A, Kiel ME, Shi Y, McKinnon RD. Adjunctive MSCs enhance myelin
formation by xenogenic oligodendrocyte precursors transplanted in the retina. Cell
Res. 2010, 20:728-31.
60. Shi YF, Hu GZ, Su JJ, Li WZ, Chen Q, Shou PS, Xu CL, Chen XD, Huang Y, Zhu
ZX, Huang X, Han XY, Xie NX, Ren GW. Mesenchymal stem cells: a new strategy
for immunosuppression and tissue repair. Cell Res. 2010, 20: 519-528.
61. Ye W, Gong X, Xie J, Wu J, Zhang X, Ouyang Q, Zhao X, Shi Y, Zhang X. AChE
deficiency or inhibition decreases apoptosis and p53 expression and protects
renal function after ischemia/reperfusion. Apoptosis. 2010, 15:474-87.
62. Yamaza T, Kentaro A, Chen C, Liu Y, Shi Y, Gronthos S, Wang S, Shi S.
Immunomodulatory properties of stem cells from human exfoliated deciduous
teeth. Stem Cell Res Ther. 2010, 1:5.
63. Ren GW, Zhao X, Zhang LY, Zhang JM, L’Huillier A, Ling WF, Roberts AI, Le AD,
Shi ST, Shao CS, and Shi YF. Inflammatory Cytokine-Induced Intercellular
Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal
Stem Cells Are Critical for Immunosuppression. J Immunol. 2010, 184:2321-2328.
64. Markovina S, Callander NS, O´Connor SL, Xu G, Shi Y, Leith CP, Kim K, Trivedi P,
Kim J, Hematti P, Miyamoto S. Bone marrow stromal cells from multiple myeloma
patients uniquely induce bortezomib resistant NF-kappaB activity in myeloma cells.
Mol Cancer. 2010, 9:176-188.
65. Zhao X, Ren GW, Liang L, Zheng B, Tischfield JA, Shi YF, Shao CS. Brief report:
IFN-γ induces expansion of Lin-Sca-1+C-Kit+ Cells. Stem Cells. 2010, 28:
122-126.
66. Zhang Q, Shi S, Liu Y, Uyanne J, Shi Y, Shi S, Le AD. Mesenchymal stem cells
derived from human gingiva are capable of immunomodulatory functions and
ameliorate inflammation-related tissue destruction in experimental colitis. The
Journal of Immunology 2009, 183:7787-7798.
67. Das J, Ren GW, Zhang LY, Roberts IA, Zhao X, Bothwel ALM, Kaer LV, Shi YF,
Das G. Transforming growth factor β is dispensable for the molecular
orchestration of Th17 cell differentiation. J Exp Med 2009 Oct
29;206(11):2407-16.
68. Izotova LS, Krause CD, Ren G, Yuan ZR, Shi Y, Pestka S. Visualizing engineered
interferon-producing cells with multicistronic vectors and fluorescent proteins.
Cytokine 2009, 48: 94.
69. Kong L, Sun L, Zhang H, Liu Q, Liu Y, Qin L, Shi G, Hu JH, Xu A, Sun YP, Li D,
Shi YF, Zang JW, Zhu J, Chen Z, Wang ZG, Ge BX. An essential role for RIG-I in
toll-like receptor-stimulated phagocytosis. Cell Host Microbe (by Cell Press) 2009,
6:150-161.
70. Ren G, Su J, Zhang L, Zhao X, Ling W, L´huillie A, Zhang J, Lu Y, Roberts AI, Ji W,
Rabson AB, Shi YF. Species Variation in the Mechanisms of Mesenchymal Stem
Cell-Mediated Immunosuppression. Stem Cells. 2009, 27:1954-1962.
71. Shi Y, Zhu J, Salomoni P, Tucci P, Lu X. A Sino-British frontier workshop of
cancer biology. Cell Death & Differentiation 2009, 16:648-650.
72. Vavassori S, Shi Y, Chen CC, Ron Y, Covey LR. In vivo post-transcriptional
regulation of CD154 in mouse CD4+ T cells. Eur J Immunol 2009, 39:2224-2232.
73. Xu G, Zhang Y, Zhang L, Roberts, A.I., Shi YF. C/EBPβ Mdiates the Synergistic
Upregulation of Gene Expression by IFN-γ and TNF-α in Bone Marrow-Derived
Mesenchymal Stem Cells. Stem Cells. 2009, 27:942-984.
74. Wang KX, Shi YF, Ron Y, Kazanecki CC, Denhardt DT. Plasma osteopontin
modulates chronic restraint stress-induced thymus atrophy by regulating stress
hormones: inhibition by an anti-osteopontin monoclonal antibody. Journal of
Immunology 2009, 182:2485-2491.
75. Izotova LS, Krause CD, Ren G, Yuan ZR, Shi Y, Pestka S. PP2-014 Visualizing
engineered interferon-producing cells with multicistronic vectors and fluorescent
proteins. Abstracts/Cytokine 2009, 48:91-137.
76. Qian Y, Shi Y. Natural killer cells go inside: entosis versus cannibalism. Cell Res.
2009; 9:1320-1321.
77. Xu G, Zhang Y, Zhang L, Ren G, Shi YF. Bone marrow stromal cells induce
apoptosis of lymphoma cells in the presence of IFNgamma and TNF by producing
nitric oxide. Biochem Biophys Res Commun. 2008, 375: 666-670.
78. Ren GW, Su JJ, Zhao X, Zhang LY, Zhang JM, Roberts AI, Zhang HT, Das G, Shi
YF. Apoptotic cells induce immunosuppression through dendritic cells: critical
roles of IFN-gamma and nitric oxide. Journal of immunology. 2008, 181: 3277-84.
79. Zhao RC, Zhu YS, Shi YF. New Hope for Cancer Treatment: exploring the
distinction betweennormal adult stem cells and cancer stem cells. Pharmacology
and Therapeutics. 2008, 119: 74-82.
80. Zhang YY, Xu GW, Zhang LY, Roberts AI, Shi YF. Th17 Cells Undergo
Fas-mediated Activation-induced Cell Independent of IFN-γ. J. Immunol. 2008,
181: 190-196.
81. Yuan ZR and Shi YF. Chloramphenicol induces abnormal cell differentiation and
inhibits apoptosis in activated T cells: possible links to leukemogenesis. Cancer
Research. 2008, 68: 4875-4881.
82. Zhang J, Jiang H, Gao W, Wu J, Peng K, Shi Y, Zhang X. The JNK/AP1/ATF2
pathway is involved in H 2 O 2-induced acetylcholinesterase expression during
apoptosis. Cell Mol Life Sci 2008, 65:1435-1445.
83. Shi YF and August DA. A New Trick for an Old Drug: mTOR Inhibitor Rapamycin
Augments the Effect of Fluorouracil on Hepatocellular Carcinoma through
Inducing Cell Senescence. Commentary. Cancer Biology and Therapeutics. 2008,
7:397-8.
84. Ren GW, Zhang LY, Zhao X, Xu GW, Zhang YY, Roberts AI, Zhao RC, and Shi
YF. Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted
Action of Chemokines and Nitric Oxide. Cell Stem Cell (by Cell Press). 2008, 2:
141-150.
85. Zhu H, Gao W, Jiang H, Jin QH, Shi YF, Tsim KW, Zhang XJ. Regulation of
acetylcholinesterase expression by calcium signaling during calcium ionophore
A23187- and thapsigargin-induced apoptosis. Int J Biochem Cell Biol. 2007, 39:
93-108.
86. Zhu H, Gao W, Shi YF, Zhang XJ. The CCAAT-binding factor CBF/NF-Y regulates
the human acetylcholinesterase promoter activity during calcium ionophore
A23187-induced cell apoptosis. Biochim Biophys Acta-General Subjects. 2007,
1770: 1475-1482.
87. Chen L, Zhang W, Yue H, Han Q, Chen B, Shi M, Li J, Li B, You S, Shi Y, Zhao
RC. Effects of human mesenchymal stem cells on the differentiation of dendritic
cells from CD34+ cells. Stem Cells Dev. 2007, 16(5): 719-31.
88. Xu G, Zhang Y, Zhang L, Ren G, Shi Y. The role of IL-6 in inhibition of lymphocyte
apoptosis by mesenchymal stem cells. Biochem Biophys Res Comm. 2007, 361:
745-50.
89. Wang K, Desai B, Shi Y* and Denhardt DT*. Osteopontin regulates
hindlimb-unloading-induced lymphoid organ atrophy through modulating
corticosteroid production. PNAS 2007, 104:14777-14782.
90. Ehirchiou D, Amarnath S, Xiong Y, Xu G, Chen W, Shi Y and Zhang L. CD11b
Facilitates the Development of Peripheral Tolerance by Suppressing Th17
Differentiation. J Exp Med. 2007, 204: 1519-24.
91. Xu GW and Shi YF. Apoptosis signaling pathways and lymphocyte homeostasis.
Cell Res. 2007, 17: 759-71.
92. Zhu H, Gao W, Jiang H, Wu J, Shi YF, Zhang XJ. Calcineurin mediates
acetylcholinesterase expression during calcium ionophore A23187-induced HeLa
cell apoptosis. Biochim Biophys Acta-Molecular Cell Res. 2007, 1773: 593-602.
93. Swaims AY, Devadas SY, Shi Y, AB Rabson. Immune stimulation of LTR-tax
transgenic CD4 (+) T cells induces hyperproliferation, hyperresponsiveness, and
prolonged cell survival. Aids Research and Human Retroviruses 2007,
23:638-638.
94. Xu G, Zhang L, Ren G, Yuan Z, Zhang Y, Zhao R, Shi Y. Immunosuppressive
properties of cloned bone marrow mesenchymal stem cells. Cell Res 2007,
17:240-248.
95. Das J, Eynott P, Van Kaer L, Das G* and Shi Y*. NKT cells and CD8+ T-cells are
dispensable for T-cell dependent allergic airway inflammation. Nature Medicine
2006, 12:1345-1346.
96. Das G, Mittal J, Zhang YY, Bothwell A, Van Kare Luc, and Shi YF. Pivotal Roles of
Major Histocompatibility Complex Class Ib Restricted CD8+ T Cells in
Autoimmune Diseases. J Exp Med. 2006, 203: 2603-11.
97. Devadas S, Das J, Liu C, Zhang L, Roberts AI, Pan Z, Moore PA, Das G, Shi Y.
Granzyme B is critical for T cell receptor-induced cell death of Type 2 helper T
cells. Immunity 2006, 25:237-247.
98. Shi Y, Roberts AI, Sun E. Dying T lymphocytes call for the death of tumor cells.
Commentary. Cell Res. 2006, 16(8): 679-80.
99. Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee
C, Shi Y, Gelinas C, Fan Y, Nelson DA, Jin S, White E. Autophagy promotes
tumor cell survival and restricts necrosis, inflammation, and tumorigenesis.
Cancer Cell. 2006, 10: 51-64.
100. Devadas S, Liu C, Shi Y. Novel helper T cell subset helps other T cells through
producing GM-CSF. The Journal of Immunology 2006, 176:S14-S15.
101. Shi YF and Devadas A. Granulocyte Macrophage Colony Stimulating Factor
(GM-CSF) and T-Cell Responses: What We Do and Don´t Know. Cell Res. 2006,
16: 126-33.
102. Yuan ZR, Wang RX, Lou XY, Zhang LY and Shi YF. Identification and
Characterization of a Novel Cell Survival Gene Critical in Apoptosis and
Tumorigenesis. Cancer Research. 2005, 65: 10716-24.
103. Greeneltch KM, Kelly-Welch AN, Keegan AD and Shi YF. Chronic Morphine
Administration Promotes Th2 Differentiation via a Fas/FasL-Dependent
Mechanism. J Immunol. 2004, 175: 4999-5005.
104. Greeneltch KM, Haudenschild CC, Keegan AD, Shi YF. The Opioid Antagonist
Naltrexone Blocks Acute Endotoxic Shock by Inhibiting Tumor Necrosis Factor-a
Production. Brain Behav Immun. 2004, 18: 476-84.
105. Sun EW, Gao Y, Chen JF, Roberts AI, Wang XN, Chen ZH, and Shi YF. Allograft
Tolerance Induced by Donor Apoptotic Lymphocytes Requires Phagocytosis in
the Recipient. Cell Death and Diff. 2004, 11: 1258-1264.
106. Jin QH, He HY, Shi YF, Lu H, Zhang XJ. Overexpression of acetylcholinesterase
inhibited cell proliferation and promoted apoptosis in NRK cells. Acta Pharmacol
Sin. 2004, 25: 1013-21.
107. Pestka S, Krause C, Sarkar D, Walter M, Shi YF, Fisher P. IL-10, Interferons and
Related Class 2 Cytokines and Receptors. Ann Rev Immunol. 2004, 22: 929-979.
108. Roberts AI, Devadas S, Zhang X, Zhang L, Keegan A, Greeneltch K, Solomon J,
Wei L, Das J, Sun E, Liu C, Yuan Z, Zhou JN, Shi Y. The role of activation-induced
cell death in the differentiation of T-helper-cell subsets. Immunologic Research
2003, 28:285-293.
109. Wei LX, Zhou JN, Roberts AI, Shi YF. Lymphocyte Reduction Induced by
Hindlimb Unloading: Distinct Mechanisms in the Spleen and Thymus. Cell Res.
2003, 13: 465-71.
110. Shi YF, Devadas S, Greeneltch KM, Yin D, Allan Mufson R and Zhou J. Stressed
to death: Implication of lymphocyte apoptosis for psychoneuroimmunology. Brain
Behav Immun. 2003, 17: 18-26.
111. Solomon JC, Sharma K, Wei LX, Fujita T and Shi YF. A Novel Role for
Sphingolipid Intermediates in Activation- Induced Cell Death in T-cells. Cell Death
Differ. 2003, 10: 193-202.
112. Zhang XR, Zhang LY, Devadas S, Li L, Keegan AD and Shi YF. Reciprocal
Expression of TRAIL and CD95L in Th1 and Th2 Cells: Role of Apoptosis in T
Helper Subset Differentiation. Cell Death Differ. 2003, 10: 216-224.
113. Jin QH, Shi YF, He HY, Ng KK, Jiang H, Yang L, Jiang ZQ and Zhang XJ.
Isolation of acetylcholinesterase from apoptotic human lung fibroblast cells by
antibody affinity chromatography. Biotechniques. 2002, Suppl: 92-94.
114. Wang RX and Shi YF. A simplified protocol for apoptosis assay by DNA content
analysis. Biotechniques. 2002, Suppl: 88-91.
115. Tonon G, Luo X, Greco NJ, Chen W, Shi YF and Jamieson GA. Weak platelet
agonists and U46619 induce apoptosis-like events in platelets, in the absence of
phosphatidylserine exposure. Thromb Res. 2002, 107: 345-350.
116. Zhang XJ, Yang L, Zhao Q, Caen JP, He HY, Jin QH, Guo LH, Alemany M,
Zhang LY and Shi YF. Induction of acetylcholinesterase expression during
apoptosis in various cell types. Cell Death Differ. 2002, 9: 790-800.
117. Li L, Qi X, Williams M, Shi YF and Keegan AD. Overexpression of insulin
receptor substrate-1, but not insulin receptor substrate-2, protects a T cell
hybridoma from activation- induced cell death. J Immunol. 2002, 168: 6215-6223.
118. Wang R, Zhang L, Zhang X, Moreno J, Celluzzi C, Tondravi M and Shi YF.
Regulation of activation-induced receptor activator of NF-kappaB ligand (RANKL)
expression in T cells. Eur J Immunol. 2002, 32: 1090-1098.
119. Gao Y, Shuang W, Shi Y, Sun E. Permanent liver allograft survival induced by
transfusion of apoptotic donor splenocyte without immunosuppression. Cell Res
2002, 12:272-273.
120. Sun EW and Shi YF. Apoptosis: the quiet death silences the immune system.
Pharmacol Ther. 2001, 92: 135-145.
121. Gubina E, Luo X, Kwon E, Sakamoto K, Shi YF and Mufson RA. Betac cytokine
receptor-induced stimulation of cAMP response element binding protein
phosphorylation requires protein kinase C in myeloid cells: a novel cytokine signal
transduction cascade. J Immunol. 2001, 167: 4303-4310.
122. Wang R, Zhang L, Zhang X, Moreno J, Luo X, Tondravi M and Shi YF.
Differential regulation of the expression of CD95 ligand, receptor activator of
nuclear factor-kappa B ligand (RANKL), TNF-related apoptosis-inducing ligand
(TRAIL), and TNF-alpha during T cell activation. J Immunol. 2001, 166:
1983-1990.
123. Sharma K, Wang RX, Zhang LY, Yin DL, Luo XY, Solomon JC, Jiang RF,
Markos K, Davidson W, Scott DW and Shi YF. Death the Fas way: regulation and
pathophysiology of CD95 and its ligand. Pharmacol Ther. 2000, 88: 333-347.
124. Yin D, Tuthill D, Mufson RA and Shi YF. Chronic restraint stress promotes
lymphocyte apoptosis by modulating CD95 expression. J Exp Med. 2000, 191:
1423-1428.
125. Yin D, Zhang L, Wang R, Radvanyi L, Haudenschild C, Fang Q, Kehry MR and
Shi YF. Ligation of CD28 in vivo induces CD40 ligand expression and promotes B
cell survival. J Immunol. 1999, 163: 4328-4334.
126. Sharma K and Shi YF. The yins and yangs of ceramide. Cell Res. 1999, 9: 1-10.
127. Yin D, Mufson RA, Wang R and Shi YF. Fas-mediated cell death promoted by
opioids. Nature. 1999, 397: 218.
128. Su Y, Damjanovski S, Shi YF and Shi YB. Molecular and cellular basis of tissue
remodeling during amphibian metamorphosis. Histol Histopathol. 1999, 14:
175-183.
129. Wang R, Brunner T, Zhang L and Shi YF. Fungal metabolite FR901228 inhibits
c-Myc and Fas ligand expression. Oncogene. 1998, 17: 1503-1508.
130. Wang R, Zhang L, Yin D, Mufson RA and Shi YF. Protein kinase C regulates Fas
(CD95/APO-1) expression. J Immunol. 1998, 161: 2201-2207.
131. Zamorano J, Wang HY, Wang R, Shi YF, Longmore GD and Keegan AD.
Regulation of cell growth by IL-2: role of STAT5 in protection from apoptosis but
not in cell cycle progression. J Immunol. 1998, 160: 3502-3512.
132. Su Y, Shi YF, Stolow MA and Shi YB. Thyroid hormone induces apoptosis in
primary cell cultures of tadpole intestine: cell type specificity and effects of
extracellular matrix. J Cell Biol. 1997, 139: 1533-1543.
133. Shi YF, Wang R, Sharma A, Gao C, Collins M, Penn L and Mills GB. Dissociation
of cytokine signals for proliferation and apoptosis. J Immunol. 1997, 159:
5318-5328.
134. Liang FT, Granstrom DE, Timoney JF and Shi YF. Micropreparative high
resolution purification of proteins by a combination of sodium dodecyl
sulfate-polyacrylamide gel electrophoresis, isoelectric focusing, and membrane
blotting. Anal Biochem. 1997, 250: 61-65.
135. Shi YF, Hill M, Novak A, Chen ZQ, Wang RX, Liew CC and Mills GB. Human
hematopoietic cell express two forms of the cytokine receptor common
gamma-chain (gamma c). Cell Res. 1997, 7: 195-205.
136. Su Y*, Shi YF* and Shi YB. Cyclosporin A but not FK506 inhibits thyroid
hormone-induced apoptosis in tadpole intestinal epithelium. Faseb J. 1997, 11:
559-565. (*equal contribution)
137. Wang R, Fang Q, Zhang L, Radvany L, Sharma A, Noben-Trauth N, Mills GB
and Shi YF. CD28 ligation prevents bacterial toxin-induced septic shock in mice
by inducing IL-10 expression. J Immunol. 1997, 158: 2856-2861.
138. Liang T, Granstrom DE and Shi YF. Concentrating protein samples for sodium
dodecyl sulphate-polyacrylamide gel electrophoresis and isoelectric focusing
using protein-blotting membranes. J Chromatogr A. 1997, 764: 143-150.
139. Radvanyi LG, Shi YF, Mills GB and Miller RG. Cell cycle progression out of G1
sensitizes primary-cultured nontransformed T cells to TCR-mediated apoptosis.
Cellular immunology. 1996, 170: 260-273.
140. Scott DW, Grdina T and Shi YF. T cells commit suicide, but B cells are murdered!
J Immunol. 1996, 156: 2352-2356.(Cutting Edge)
141. Shi Y*, Radvanyi LG*, Vaziri H, Sharma A, Dhala R, Mills GB and Miller RG.
CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell
response. The Journal of Immunology 1996, 156:1788-1798.
142. McGahon AJ, Martin SJ, Bissonnette RP, Mahboubi A, Shi YF, Mogil RJ,
Nishioka WK and Green DR. The end of the (cell) line: methods for the study of
apoptosis in vitro. Methods Cell Biol. 1995, 46: 153-185.
143. Shi YF*, Radvanyi LG*, Sharma A, Shaw P, Green DR, Miller RG and Mills GB.
CD28-mediated signaling in vivo prevents activation-induced apoptosis in the
thymus and alters peripheral lymphocyte homeostasis. J Immunol. 1995, 155:
1829-1837. (*equal contribution)
144. Shi YF, Frankel A, Radvanyi LG, Penn LZ, Miller RG and Mills GB. Rapamycin
enhances apoptosis and increases sensitivity to cisplatin in vitro. Cancer Res.
1995, 55: 1982-1988.
145. Green DR, Mahboubi A, Nishioka W, Oja S, Echeverri F, Shi YF, Glynn J, Yang
Y, Ashwell J and Bissonnette R. Promotion and inhibition of activation-induced
apoptosis in T-cell hybridomas by oncogenes and related signals. Immunol Rev.
1994, 142: 321-342.
146. Rabinovitch A, Suarez-Pinzon WL, Shi YF, Morgan AR and Bleackley RC. DNA
fragmentation is an early event in cytokine-induced islet beta-cell destruction.
Diabetologia. 1994, 37: 733-738.
147. Mogil RJ*, Shi YF*, Bissonnette RP, Bromley P, Yamaguchi I and Green DR.
Role of DNA fragmentation in T cell activation-induced apoptosis in vitro and in
vivo. J Immunol. 1994, 152: 1674-1683. (*equal contribution)
148. Mills GB, Schmandt R, Gibson S, Leung B, Hill M, May C, Shi YF, Branch DR,
Radvanyi L, Truitt KE and et al. Transmembrane signaling by the interleukin-2
receptor: progress and conundrums. Semin Immunol. 1993, 5: 345-364.
149. Shi YF, Kornovski BS, Savani R and Turley EA. A rapid, multiwell colorimetric
assay for chemotaxis. J Immunol Methods. 1993, 164: 149-154.
150. Helgason CD, Shi L, Greenberg AH, Shi YF, Bromley P, Cotter TG, Green DR
and Bleackley RC. DNA fragmentation induced by cytotoxic T lymphocytes can
result in target cell death. Exp Cell Res. 1993, 206: 302-310.
151. Green DR, Bissonnette RP, Glynn JM and Shi YF. Activation-induced apoptosis
in lymphoid systems. Semin Immunol. 1992, 4: 379-388.
152. Green DR, Zheng H and Shi YF. Antisense oligodeoxynucleotides as probes of
T-lymphocyte gene function. Ann N Y Acad Sci. 1992, 660: 193-203.
153. Shi YF, Glynn JM, Guilbert LJ, Cotter TG, Bissonnette RP and Green DR. Role
for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science.
1992, 257: 212-214. (with cover illustration)
154. Shi YF, Bissonnette RP, Parfrey N, Szalay M, Kubo RT and Green DR. In vivo
administration of monoclonal antibodies to the CD3 T cell receptor complex
induces cell death (apoptosis) in immature thymocytes. J Immunol. 1991, 146:
3340-3346.
155. Shi YF, Szalay MG, Paskar L, Sahai BM, Boyer M, Singh B and Green DR.
Activation-induced cell death in T cell hybridomas is due to apoptosis.
Morphologic aspects and DNA fragmentation. J Immunol. 1990, 144: 3326-3333.
156. Shi YF, Sahai BM and Green DR. Cyclosporin A inhibits activation-induced cell
death in T-cell hybridomas and thymocytes. Nature. 1989, 339: 625-626.
157. Shi YF, Mahrt JL and Mogil RJ. Kinetics of murine delayed-type hypersensitivity
response to Eimeria falciformis (Apicomplexa: Eimeriidae). Infect Immun. 1989,
57: 146-151.
158. Mahrt JL and Shi YF. Murine major histocompatibility complex and immune
response to Eimeria falciformis. Infect Immun. 1988, 56: 270-271．
专著
BOOKS CHARPTERS
159. Sun E, Zhang L, Roberts AI, Liu C and Shi Y. Chronic stress induced death of
lymphocytes. Cytokines: Stress and Immunity Second Edition, edited by Nicholas
P Plotnikoff, Robert E Faith, Anthony J Murgo, and Robert A Good. 2005, CRC
Press.
160. Shi Y, Devadas S, Zhang X, Zhang L, Keegan AD, Greeneltch K, Solomon JC,
Yuan Z, Sun E, Liu C, Das J, Thayyil-Satish M, Wei L, Zhou J and Roberts AI.
Activation-Induced Cell Death and T Helper Subset Differentiation. In Shi YF,
Cidlowski J, Scott DW and Shi YB. (Eds.) Molecular Mechanisms of
Programmmed Cell Death Kluwer Academic/Plenum Publishers, New York 2003.
161. Sun E and Shi Y. The mechanisms and significance of immune tolerance
induced by apoptotic cells. In Shi YF, Cidlowski J, Scott DW and Shi YB. (Eds.).
Molecular Mechanisms of Programmed Cell Death Kluwer Academic/Plenum
Publishers, New York 2003.
162. Wang R, Zhang L, Yin D, Mufson RA and Shi Y. Regulation of Fas and FasL
expression during activation-induced T-cell apoptosis. In Talwar GP, Nath I,
Ganguly NK and Rao KVS. (Eds.) Proceedings of 10th International Congress of
Immunology Monduzzi Editore, Bologna, Italy 1999, pp 499-505.
163. Shi Y, Mills GB and Wang R. Mitogenic Cytokines Promote Apoptosis: Possible
Roles in Cellular Homeostasis. In Shi YB, Shi YF, Scott DW and Xu YH. (Eds.)
Current Advances in Programmed Cell Death Plenum Publishing Corp., New York
1997, pp 113-142.
164. Scott DW, Brunner T, Donjerkovic D, Ezhevsky S, Grdina T, Green DR, Shi Y
and Yao X. Murder and suicide: A tale of T and B cell apoptosis. In Shi YB, Shi YF,
Scott DW and Xu YH. (Eds.) Current Advances in Programmed Cell Death
Plenum Publishing Corp., New York 1997, pp 91-103.
165. Shi Y and Wang R. Apoptosis and immune regulation. In Li C, Guo Y, Yie Q and
Tang X. (Eds.) Current Advance in Tumor Molecular Biology Medical Science
Publisher, Beijing 1996, pp 61-69.
166. Scott DW, Ezhevksy S, Maddox B, Washart K, Yao X and Shi Y. Scenes from
short life: checkpoints and progression signals for immature B-cell life versus
apoptosis. In Rigley K, and Harnett M. (Eds.). John Wiley, Chichester, England.
1995, pp 165-175.
167. Green DR, Shi Y, Glynn JM, Mahboubi A and Mogil RJ. Myc, Fas, apoptosis, and
immune tolerance. In: Apoptosis. In Mihich E and Schimke RT. (Eds.) Apoptosis
Plenum Press, New York 1994, pp 213-222.
168. Bissonnette RP, Shi Y, Mahboubi A, Glynn JM. C-myc and apoptosis. Current
Communications in Cell and Molecular Biology 1994, 327-327.
169. Bissonnette RP, Shi Y, Mahboubi A, Glynn JM and Green DR. C-myc and
apoptosis. In Tomei LD and Cope FO. (Eds.) Apoptosis II: The Molecular Basis of
Cell Death Cold Spring Harbor Lab Press, Cold Spring Harbor, New York 1994, pp
327-335.
170. Green DR and Shi Y. Activation-induced cell death in developing T cells and T
cell hybridomas. In Malhotra SK. (Ed.) Advances in Structural Biology JAI Press,
Inc. 1990, pp 287-299.
BOOKS EDITED
1. Shi YB, Shi Y, Scott DW, and Xu Y. 1997. Programmed Cell Death. Plenum
Press, New York.
2. Shi Y, Cidlowski J, Scott DW, and Shi YB. 2003. Molecular Mechanisms of
Programmmed Cell Death. Kluwer Academic/Plenum Publishers, New York.
3. Liu X, Pestka S. Shi Y, Cidlowski J. 2007 Selected Papers from the 2005
Annual Meeting of the International Society for Interferon and Cytokine Research
(ISICR): Interferons and Cytokines. Shanghai Scientific and Technical Publishers.
4. Liu X, Pestka S and Shi Y. Recent Advance in Cancer Research and Therapy.
Elsevier 2012.