Sari Izenwasser, Ph.D.
Professor
Psychiatry and Behavioral Sciences
Neuroscience Program
Office Phone: (305) 243-2032 FAX: (305) 243-5475
Education
1980
B.A. (High Honors) Psychology
Florida International University, Miami,. FL
1983
M.A. Experimental/Physiological Psychology
Boston University, Boston, MA
1987
Ph.D. Experimental/Physiological Psychology
Boston University, Boston, MA
Professional Experience
1997-present Professor
University of Miami Miller School of Medicine
Department of Psychiatry and Behavioral Sciences
Neuroscience Program
Publications
Books and Monographs
1.
Trudell, M.L. and Izenwasser, S. (eds). Dopamine Transporters. Chemistry, Biology, and
Pharmacology. John Wiley & Sons, Inc., New Jersey. 2009.
2.
Izenwasser, S. The role of the dopamine transporter in cocaine abuse. Review Article,
Neurotoxicity Research, 6:379-384, 2004.
3.
Mash, D.C., Kramer, L.C. and Izenwasser, S. Dopamine transporter mRNA in human
brain: distribution and regulatory effects in autopsy studies of cocaine abusers. In: Cerebral
Signal Transduction: From First to Fourth Messengers, (M.E.A. Reith, ed.) Humana Press,
pp. 401-417, 2000.
4.
Izenwasser, S. Basic pharmacological mechanisms of cocaine. In: Cocaine abuse: Basic
determinants, clinical applications, and policy. (S. Higgins and J.L. Katz, eds.) Academic
Press, pp.1-20, 1998.
5.
Adams, J.U., Izenwasser, S., Kramer, T.H., Stevens, C.W., Tiseo, P.J., and Unterwald, E.M.
Mechanisms of sensitization. Presentation in symposium entitled: Tolerance and
1
sensitization to opioids and cocaine. NIDA Research Monograph, Problems of Drug
Dependence, 140, 69-73 1993.
6.
Izenwasser, S. and Kornetsky, C. Brain-stimulation reward: A method for assessing the
neurochemical bases of drug-induced euphoria. In: Drugs of Abuse and Neurobiology
(ed. R.R. Watson), CRC Press, Boca Raton, FL, pp. 1-22, 1992.
Scientific Articles in Reviewed Journals
1.
Roebber, J.K., Izenwasser, S., and Chaudhari, N. Cocaine decreases saccharin preference
without altering sweet taste sensitivity. Pharmacology, Biochemistry and Behavior, 133:1824, 2015. PMID: 25812471
2.
Lenoir, M., Starosciak, A.K., Ledon, J., Booth, C., Zakharova, E., Wade, D., Vignoli, B.,
and Izenwasser, S. Sex differences in conditioned nicotine reward are age-specific.
Pharmacology, Biochemistry and Behavior, 132: 56-62, 2015. PMID: 25735492
3.
Thaxton, A., Izenwasser, S., Wade, D., Stevens, E.D., Mobley, D.L., Jaber, V., Lomenzo,
S.A., and Trudell, M.L. 3- Aryl-3-arylmethoxyazetidines. A new class of high affinity
ligands for monoamine transporters. Bioorg. Med. Chem. Letts., 23:4404-4407, 2013.
PMID: 23806554
4.
Starosciak, A.K., Zakharova, E., Stagg, M., Matos, J., and Izenwasser, S. Differential
alteration of the effects of MDMA (ecstasy) on locomotor activity and cocaine conditioned
place preference in male adolescent rats by social and environmental enrichment.
Psychopharmacology, 224:101-108, 2012. PMID: 22752351
5.
Papudippu, M. , Shu, H., Izenwasser, S., Wade, D., Gulasey, G., Fournet, S., Stevens, E.D.,
Lomenzo, S. and Trudell, M.L. Regioselective synthesis and cannabinoid receptor binding
affinity of N-alkylated 4,5-diaryl-1,2,3-triazoles, Med. Chem. Res., 21: 4473-4484, 2012.
6.
Zakharova, E., Starosciak, A., Wade, D., and Izenwasser, S. Sex differences in the effects
of social and physical environment on novelty-induced exploratory behavior and cocainestimulated locomotor activity in adolescent rats, Beh. Brain Research, 230:92-99, 2012.
PMID: 22327184
7.
Cararas, S.A., Izenwasser, S., Wade, D., Housman, A., Verma, A., Lomenzo, S.A., and
Trudell, M.L. Further structure-activity relationship studies on 8-substituted-3-[2(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine
transporters, Bioorg. Med. Chem., 19:7551-7558, 2011. PMID: 220557156
8.
Dow-Edwards, D. and Izenwasser, S. Pretreatment with Δ9-tetrahydrocannabinol (THC)
increases cocaine-stimulated activity in adolescent but not adult male rats. Pharmacology,
Biochemistry and Behavior, 100:587-591, 2012. PMID: 21951601
9.
Gu, X., Izenwasser, S., Wade, D., Housman, A., Gulasey, G., Rhode, J.B., Savoie, C.D.,
Mobley, D.L., Lomenzo, S.A., and Trudell, M.L. Synthesis and structure-activity studies of
2
benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter
ligands. Bioorg. Med. Chem., 18:8356-8364, 2010. PMID: 20980153
10.
Walsh, S.L., Unterwald, E.M., Izenwasser, S., Introduction to the College on Problems of
Drug Dependence special issue: Contemporary advances in opioid neuropharmacology.
Drug and Alcohol Dependence, 2010. PMID: 20378280
11.
Kaur, H., Izenwasser, S., Verma, A., Wade, D., Housman, A., Stevens, E.D., Mobley, D.L.
and Trudell, M.L. Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy3beta-arylnortropanes. Bioorganic and Medicinal Chemistry Letters, 19:6865-6868, 2009.
PMID: 19896846
12.
Zakharova, E., Miller, J., Unterwald, E., Wade, D., and Izenwasser, S. Social and physical
environment alter cocaine conditioned place preference and dopaminergic markers in
adolescent male rats. Neuroscience, 163: 890-897, 2009. (online 7/4/09). PMID: 19580849
13.
Werling, L.L., Reed, S.C., Wade, D., and Izenwasser, S. Chronic nicotine alters
cannabinoid-mediated locomotor activity and receptor density in periadolescent but not
adult male rats. International Journal of Developmental Neuroscience, 27:263-269, 2009.
PMID: 19167478.
14.
Zakharova, E., Wade, D., and Izenwasser, S. Sensitivity to cocaine conditioned reward
depends on sex and age. Pharmacology Biochemistry and Behavior, 92: 131-134, 2009.
PMID: 19032962
15.
Zakharova, E., Leoni, G., Kichko, I., and Izenwasser, S. Differential effects of
methamphetamine and cocaine on conditioned place preference and locomotor activity in
adult and adolescent male rats, Behavioural Brain Research, 198: 45-50, 2009. PMID:
18996417
16.
Shu, H., Izenwasser, S., Wade, D., Stevens, E.D., Trudell, M.L. Synthesis and CB1
cannabinoid receptor affinity of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles. Bioorganic
and Medicinal Chemistry Letters, 19: 891-893, 2009. PMID: 19097888
17.
Zakharova, E., Collins, S.L., Aberg, M., Kumar, A., Fernandez, J.B., and Izenwasser, S.
Depletion of serotonin decreases the effects of the kappa-opioid receptor agonist U-69593
on cocaine-stimulated activity. Eur. J. Pharmacology, 586: 123-189, 2008. PMID:
18395712
18.
Zaias, J., Queeney, T.J., Kelley, J.B., Zakharova, E.S., and Izenwasser, S. Social and
physical environmental enrichment differentially affect growth and activity of
preadolescent and adolescent male rats. J. Amer. Assoc. Lab. Anim. Sci., 47(2): 30-34,
2008. PMID: 18351719
19.
Zhang, S., Izenwasser, S., Wade, D., Cheng, J., Liu, Y., Xu, L., and Trudell, M.L.
Synthesis and nicotinic acetylcholine receptor affinity of bivalent tropane-3-carboxylates.
J. Heterocyclic Chem., 44: 1425-1430, 2007.
3
20.
Aberg, M., Wade, D., Wall, E., and Izenwasser, S. Effect of MDMA (ecstasy) on activity
and cocaine conditioned place preference in adult and adolescent rats, Neurotoxicology and
Teratology, 29:37-46, 2007. PMID: 17049207
21.
Romualdi, P., Di Benedetto, M., D’Addario, C., Collins, S., Wade, D., Candeletti, S., and
Izenwasser, S. Chronic cocaine produces decreases in N/OFQ peptide levels in select rat
brain regions, J. Molecular Neuroscience, 31:163-168, 2007.
22.
D’Addario, C., Di Benedetto, M., Izenwasser, S., Candeletti, S., and Romualdi, P. Role of
serotonin in the regulation of the dynorphinergic system by a kappa-opioid agonist and
cocaine treatment in rat CNS. Neuroscience, 144: 163-168, 2007. PMID: 17478889
23.
Zhang, S, Izenwasser, S., Wade, D., Xu, L., and Trudell, M.L. Synthesis of dopamine
transporter selective 3-(diarylmethoxymethyl)-8-arylalkyl-8-azabicyclo[3.2.1]octane
derivatives, Bioorganic and Medicinal Chemistry Letters., 14: 7943-7952, 2006.
24.
Izenwasser, S. Differential effects of psychoactive drugs in adolescents and adults, Critical
Reviews in Neurobiology, 17:51-68, 2005. PMCID: PMC1752119
25.
Rhoden, J.B., Bouvet, M., Izenwasser, S., Wade, D., Lomenzo, S.A., and Trudell, M.L.
Structure-activity studies of 3’-4’-dichloro-meperidine analogues at dopamine and serotonin
transporters, Bioorganic and Medicinal Chemistry Letters., 13:5623-5634, 2005.
26.
Lomenzo, S.A., Rhoden, J.B., Izenwasser, S., Wade, D., Katz, J.L., Kopajtic, T., Trudell, M.L.
Synthesis and biological evaluation of meperidine analogues at monoamine transporters, J. Med.
Chem., 48:1336-1343, 2005.
27.
Collins, S.L., Wade, D., Ledon, J., and Izenwasser, S. Neurochemical alterations produced by
daily nicotine exposure in periadolescent vs. adult male rats, Eur. J. Pharmacology, 502:75-85,
2004.
28.
Collins, S.L., Montano, R., and Izenwasser, S. Nicotine treatment produces persistent increases
in amphetamine-stimulated locomotor activity in periadolescent male but not female or adult
male rats. Developmental Brain Research, 153:175-187, 2004.
29.
Di Benedetto, M., Feliciani, D., D’Addario, C., Izenwasser, S., Candeletti, S., and Romualdi, P.
Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene
expression in rat CNS. Molecular Brain Research, 127:115-120, 2004.
30.
Collins, S.L. and Izenwasser, S. Chronic nicotine differentially alters cocaine-induced
locomotor activity in adolescent vs. adult male and female rats. Neuropharmacology, 46: 349362, 2004.
31.
D’Addario, C., Di Benedetto, M., Izenwasser, S., Candeletti, S., Romualdi, P. Differential
time course of the effects of kappa-opioid agonist treatment on dynorphin A and on kappaopioid receptor density, J. Molecular Neuroscience, 24:307-314, 2004.
4
32.
Cheng, J., Xu, L., Stevens, E.D., Izenwasser, S., Wade D., and Trudell, M.L. Stereoselective
synthesis of conformationally constrained tropane analogues: 6-Chloro-2,5-diazatetracyclo
[8.5.0.02,13.04,9]pentadeca-4,6,8-triene-11-one and 6-Chloro-2,7-diazatetracyclo-[8.5.0.02,13.04,9]
pentadeca-4,6,8-triene-11-one, J. Heterocyclic Chem. 41:569-574, 2004.
33.
Platt, D.M., Rowlett, J.K., Izenwasser, S., and Spealman, R.D. Opioid partial agonist effects of
3-O-methylnaltrexone in rhesus monkeys, J. Pharmacol. Exp. Ther., 308:1030-1039, 2004.
34.
Di Benedetto, M., D’Addario, C., Collins, S., Izenwasser, S., Candeletti, S., and Romualdi, P.
Role of serotonin on cocaine mediated effects on prodynorphin gene expression in the rat brain,
J. Molecular Neuroscience, 22:213-222, 2004.
35.
Xu, L., Kulkarni, S., Izenwasser, S., Katz, J.L., Kopajtic, T., Lomenzo, S.A., Newman, A.H. and
Trudell, M.L. Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 betaaryltropane derivatives. J. Med. Chem., 47:1676-1682, 2004.
36.
Cheng, J., Izenwasser, S., Zhang, C., Zhang, S., Wade, D., and Trudell, M.L. Synthesis and
nicotinic acetylcholine receptor binding affinities of 2- and 3-isoxazolyl-8azabicyclo[3.2.1]octanes. Bioorganic and Medicinal Chemistry Letters, 14:1775-1778, 2004.
37.
Winfield, L., Chunming, Z., Reid, C., Stevens, E., Izenwasser, S., Wade, D., and Trudell, M.L.
Synthesis, lipophilicity and structure of 2,5-disubstituted 1, 3, 5-dithiazine derivatives, J.
Heterocyclic Chemistry, 40, 827-832, 2003.
38.
Bradley, A.L., Izenwasser, S., Wade, D., Cararas, S., and Trudell, M.L. Synthesis of dopamine
transporter selective 3-{2-(Diarylmethoxy]ethylidene)}-8-alkylaryl-8-azabicyclo[3.2.1]octanes.
Bioorganic & Medicinal Chemistry Letters, 13:629-632, 2003.
39.
Mash, D.C., Ouyang, Q., Pablo, J., Basile, M., Izenwasser, S., Lieberman, A., and Perrin, R.
Cocaine abusers have an overexpression of -synuclein in dopamine neurons. J. Neurosci.,
23:2564-71; 2003.
40.
Izenwasser, S. and French, D. Tolerance and sensitization to cocaine are mediated via
independent mechanisms. Pharmacol. Biochem. Behav., 73:877-882, 2002.
41.
Collins, S.L. and Izenwasser, S. Cocaine differentially alters behavior and neurochemistry in
periadolescent vs. adult rats. Dev. Brain Res., 138:27-34, 2002.
42.
Bradley, A.L., Izenwasser, S., Wade, D., Klein-Stevens, C., Zhu, N., and Trudell, M.L.
Synthesis and dopamine transporter binding affinities of 3-benzyl-8-(diarylmethoxyethyl)-8azabicyclo[3.2.1]octanes, Bioorganic & Medicinal Chemistry Letters, 12:2387-2390, 2002.
43.
Collins, S.L., Kunko, P.M., Ladenheim, B., Cadet, J.-L., Carroll, F.I., and Izenwasser, S.
Chronic cocaine increases -opioid receptor density: lack of effect by selective dopamine
uptake inhibitors. Synapse, 45:153-158, 2002.
5
44.
Cheng, J., Zhang, C., Stevens, E.D., Izenwasser, S., Wade, D., Chen, S., Paul, D., and Trudell,
M.L. Synthesis and biological evaluation at nicotinic acetylcholine receptors of N-arylalkyland N-aryl-7-azabicyclo[2.2.1]heptanes. J. Med. Chem., 45:3041-3047, 2002.
45.
Winfield, L., Izenwasser, S., Wade, D., and Trudell, M.L. Synthesis and dopamine
transporter binding affinity of 2,6-dioxopiperazine analogues of GBR 12909. Med. Chem.
Res., 11:102-115, 2002.
46.
Mash, D.C., Pablo, J., Ouyang, Q., Hearn, W.L., and Izenwasser, S. Dopamine transport
function is elevated in cocaine users. J. Neurochem., 81: 292-300, 2002.
47.
Schenk, S. and Izenwasser, S. Pretreatment with methylphenidate sensitizes rats to the
reinforcing effects of cocaine. Pharmacol. Biochem. Behav., 72:651-657, 2002.
48.
Xu, L., Izenwasser, S., Katz, J.L., Kopajtic, T., Klein-Stevens, C., Zhu, N., Lomenzo, S.A.,
Winfield, L., and Trudell, M.L. Synthesis and biological evaluation of 2-substituted 3tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters. J. Med.
Chem., 45:1203-1210, 2002.
49.
Collins, S.L., D’Addario, C., Romualdi, P., Candeletti, S., and Izenwasser, S. Regulation of
dynorphin gene expression by kappa-opioid agonist treatment. NeuroReport, 13:107-109,
2002.
50.
Collins, S.L., D’Addario, C., and Izenwasser, S. Effects of kappa opioid receptor agonists on
long-term cocaine use and dopamine neurotransmission, Eur. J. Pharmacol., 426:25-34, 2001.
51.
Collins, S.L., Gerdes, R.M., D'Addario, C. and Izenwasser, S. Kappa opioid agonists alter
dopamine markers and cocaine-stimulated locomotor activity. Beh. Pharmacol., 12:237-246,
2001.
52.
Barrett, A.C., Morgan, D., Izenwasser, S. and Picker, M.J. Cocaine-like discriminative
stimulus effects and [3H]dopamine uptake inhibition produced by selected partial opioid
agonists. Beh. Pharmacol., 12:225-235, 2001.
53.
Cheng, J., Izenwasser, S., Wade, D., and Trudell, M.L. Synthesis and nicotinic acrtylcholine
receptor binding affinity of exo- and endo-2-(pyridinyloxymethyl)-7-azabicyclo[2.2.1]heptanes.
Med. Chem. Res., 10:356-365, 2001.
54.
Newman, A.H., Robarge, M.J., Howard, I.M., Wittkopp, S.L., George, C., Kopajtic, T.,
Izenwasser, S., and Katz, J.L. Structure-activity relationships at monoamine transporters and
muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4' '-dichlorosubstituted-diphenyl)methoxytropanes. J. Med. Chem., 44:633-640, 2001.
55.
Romualdi, P., D'Addario, C., Ferri, S., Cox, B.M., and Izenwasser, S. Chronic GBR 12909
administration differentially alters prodynorphin gene expression compared to cocaine. Eur. J.
Pharmacol., 413:207-212, 2001.
6
56.
Mash, D.C., Staley, J.K., Izenwasser, S., Basile, M., and Ruttenber, A.J. Serotonin transporters
upregulate with chronic cocaine abuse. J. Chemical Neuroanatomy, 20:271 – 280, 2000.
57.
Katz, J.L., Izenwasser, S., and Terry, P. Relationships among dopamine transporter
affinities and cocaine-like discriminative stimulus effects. Psychopharmacol., 148: 90-98,
2000.
58.
Robarge, M.J., Agoston, G.E., Izenwasser, S., Kopajtic, T., George, C., Katz, J.L., and
Newman, A.H. Highly selective chiral N-substituted 3-[bis(4'-fluorophenyl)methoxy]
tropane analogues for the dopamine transporter: Synthesis and comparative molecular field
analysis. J. Med. Chem., 43:1085-93, 2000.
59.
Mufson E.J.,. Deecher D.C., Basile M., Izenwasser S., and Mash, D.C. Galanin receptor
plasticity within the nucleus basalis in early Alzheimer’s Disease: an in vitro
autoradiographic analysis. Neuropharmacol., 39:1404-1412, 2000.
60.
Katz, J.L., Izenwasser, S., Kline, R.H., Allen, A.C., and Newman, A.H. Novel 3diphenylmethoxytropane analogs: Selective dopamine uptake inhibitors with behavioral
effects distinct from those of cocaine, J. Pharmacol. Exp. Ther., 288:302-315, 1999.
61.
Izenwasser, S., French, D., Carroll, F.I., and Kunko, P.M. Continuous infusion of selective
dopamine uptake inhibitors or cocaine produces time-dependent changes in rat locomotor
activity. Behavioural Brain Research, 99:201-208, 1999.
62.
Izenwasser, S., Coy, A., Ladenheim, B., Loeloff, R.J., Cadet, J.L., and French, D. Chronic
methylphenidate alters locomotor activity and dopamine transporters differently from
cocaine. Eur. J. Pharmacol., 373:187-193, 1999.
63.
Izenwasser, S., Staley, J.K., Cohn, S., and Mash, D.C. Characterization of kappa1-opioid
receptor binding in human insular cortex. Life Sciences, 65:857-862, 1999.
64.
Newman, A.H., Izenwasser, S., Robarge, M.J., and Kline, R.H. CoMFA study of novel
phenyl ring-substituted 3-(diphenylmethoxy)tropane analogues at the dopamine
transporter. J. Med. Chem., 42: 3502-3509, 1999.
65.
Husbands, S.M., Izenwasser, S., Kopajtic, T., Bowen, W.D., Vilner, B.J., Katz, J.L., and
Newman, A.H. Structure-activity relationships at the monoamine transporters and 
receptors for a novel series of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole
(rimcazole) analogs. J. Med. Chem., 42: 4446-4455, 1999.
66.
Lomenzo, S.A., Izenwasser, S., Gerdes, R.M., Katz, J.L., Kopajtic, T., and Trudell, M.L.
Synthesis, dopamine and serotonin transporter binding affinities of novel analogues of
meperidine. Bioorganic & Medicinal Chemistry Letters, 9:3273-6, 1999.
67.
Izenwasser, S., Thompson-Montgomery, D., Deben, S.E., Chowdhury, I.N., and Werling,
L.L. Modulation of amphetamine-stimulated (transporter-mediated) dopamine release by
sigma2 receptor agonists and antagonists. Eur. J. Pharmacol., 346:189-196, 1998.
7
68.
Kunko, P.M., French, D., and Izenwasser, S. Alterations in locomotor activity during
chronic cocaine administration: Effect on dopamine receptors and interaction with opioids.
J. Pharmacol. Exp. Ther., 285:277-284, 1998.
69.
Zhang, C., Izenwasser, S. Katz, J.L., Terry, P., and Trudell, M.L. Synthesis and dopamine
transporter affinity of the four stereoisomers of (±)-2-methoxycarbonyl-7-methyl-3-phenyl7-azabicyclo[2.2.1]heptane. J. Med. Chem., 41: 2430-2435, 1998.
70.
Lomenzo, S.A., Izenwasser, S., Katz, J.L., and Trudell, M.L. The effects of alkyl
substituents at the 6-position of cocaine analogues on dopamine transporter binding affinity
and dopamine uptake inhibition. Med. Chem. Res., 8:35-42,1998.
71.
Izenwasser, S., Acri, J.B., Kunko, P.M., and Shippenberg, T. Repeated treatment with the
selective kappa opioid agonist U-69593 produces a marked depletion of dopamine D2
receptors, Synapse. 30:275-283,1998.
72.
Kline, R.H., Izenwasser, S., Katz, J.L., Joseph, D.B., Bowen, W.D., and Newman, A.H. 3’Chloro-3-(diphenylmethoxy)tropane but not 4’- Chloro-3 -(diphenylmethoxy)tropane
produces a cocaine-like behavioral profile. J. Med. Chem., 40:851-857, 1997.
73.
Katz, J.L., Newman, A.H., and Izenwasser, S. Relations between heterogeneity of
dopamine transporter binding and function and the behavioral pharmacology of cocaine,
Pharmacology, Biochemistry and Behavior. 57:505-512, 1997.
74.
Xu, L., Kelkar, S.V., Lomenzo, S.A., Izenwasser, S., Katz, J.L., Kline, R.H., and Trudell,
M.L. Synthesis, dopamine transporter affinity, dopamine uptake inhibition and locomotor
stimulant activity of 2-substituted-3-phenyltropane derivatives. J. Med. Chem., 40:858863, 1997.
75.
Kunko, P.M., Loeloff, R.J., and Izenwasser, S. Chronic administration of the selective
dopamine uptake inhibitor GBR 12909, but not cocaine, produces marked decreases in
dopamine transporter density. Naunyn-Schmiedeberg’s Arch. Pharmacol., 356:562-569,
1997.
76.
Agoston, G.E., Wu, J.H., Izenwasser, S., George, C., Katz, J., Kline, R.H., and Newman,
A.H. Novel N-substituted3-(bis(4’-fluorophenylmethoxy]tropane analogs: Selective
ligands for the dopamine transporter. J. Med. Chem., 40:4329-4339, 1997.
77.
Husbands, S.M., Izenwasser, S., Loeloff, R.J., Katz, J.L., Bowen, W.D., Vilner, B.J., and
Newman, A.H. Isothiocyanate derivatives of 9-[3-cis-3,5-dimethyl-(1-piperazinyl)propyl]
carbazole (Rimcazole): Irreversible ligands for the dopamine transporter. J. Med. Chem.,
40:4340-4346, 1997.
78.
Lomenzo, S.A., Izenwasser, S., Katz, J.L., Terry, P., Zhu, N., Klein, C.L., and Trudell,
M.L. Synthesis, structure, dopamine transporter affinity and dopamine uptake inhibition of
novel 6-alkyl-3-benzyl-2-(methoxycarbonylmethyl)-tropane derivatives. J. Med. Chem.,
40: 4406-4414, 1997.
8
79.
Agoston, G.E., Vaughan, R., Lever, J.R., Izenwasser, S., Terry, P.D., Newman, A.H. A
novel photoaffinity label for the dopamine transporter based on N-substituted 3-[bis(4’fluorophenyl)methoxy]tropane. Bioorganic & Medicinal Chemistry Letters, 7:3027-3032,
1997.
80.
Izenwasser, S., Newman, A.H., Cox, B.M., and Katz, J.L. The cocaine-like behavioral
effects of meperidine are mediated by activity at the dopamine transporter. Eur. J.
Pharmacol., 297:9-17, 1996.
81.
Izenwasser, S., Heller, B. and Cox, B.M. Continuous cocaine administration enhances µbut not -opioid receptor-mediated inhibition of adenylyl cyclase activity in rat nucleus
accumbens. Eur. J. Pharmacol., 297:187-191, 1996.
82.
Aronson, B., Enmon, J.L., Izenwasser, S., Katz, J.L., Kelkar, S.V., Luo, L., Nolan, S.P., and
Trudell, M.L. Synthesis and ligand binding at cocaine receptors of 6-(2-carbomethoxy3 -phenyltropane) transition metal complexes. J. Med. Chem., 39:1560-1563, 1996.
83.
Newman, A.H., Shah, J.H., Izenwasser, S., Heller, B., Mattson, M.V., and Tortella, F.C.
Highly selective 1 ligands based on dextromethorphan. Med. Chem. Res., 6:102-117,
1996.
84.
Shah, J.H., Kline, R.H., Geter-Douglass, B., Izenwasser, S., Witkin, J.M., and Newman,
A.H. (±)-3-Cinnamyl(4’-N,N-dimethylamino)benzazepine analogs: Novel dopamine D1
receptor antagonists. J. Med. Chem., 39:3423-3428, 1996.
85.
Romualdi, P., Donatini, A., Izenwasser, S., Cox, B.M., and Ferri, S. Chronic
intracerebroventricular cocaine differentially affects prodynorphin gene expression in rat
hypothalamus and caudate putamen. Mol. Brain Res., 40:153-156, 1996.
86.
Chen, Z., Izenwasser, S., Katz, J.L., Zhu, N., Klein, C.L., and Trudell, M.L. Synthesis and
dopamine transporter affinity of 2-(methoxycarbonyl)-9-methyl-3-phenyl-9azabicyclo[3.3.1]nonane derivatives. J. Med. Chem., 39:4744-4749, 1996.
87.
Izenwasser, S. and Cote, T.E. Inhibition of adenylyl cyclase activity by a homogeneous
population of dopamine D2 receptors: Selective blockade by antisera directed against G i1
and/or Gi2. J. Neurochem., 64:1614-1621, 1995.
88.
Newman, A.H., Kline, R.H., Allen, A.C., Izenwasser, S., George, C., and Katz, J.L. Novel
4'- and 4"-substituted-3-(diphenylmethoxy)tropane analogs are potent and selective
dopamine uptake inhibitors. J. Med. Chem., 38:3933-3940, 1995.
89.
Shah, J. H., Izenwasser, S., Geter-Douglass, B., Witkin, J.M., and Newman, A.H. Nalkylaminobenzazepine analogs: Novel dopamine D1 receptor antagonists. J. Med. Chem.,
38:4284-4293, 1995.
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90.
Buzas, B., Izenwasser, S., Portoghese, P.S. and Cox, B.M. Evidence for delta opioid
receptor subtypes regulating adenylyl cyclase activity in rat brain. Life
Sciences/Pharmacology Letters, 54:PL101-106, 1994.
91.
Newman, A.H., Allen, A.C., Witkin, J.M., Izenwasser, S., Mash, D., and Katz, J.L. The
thermal decomposition product of "crack", AEME, and analogs do not appear to contribute
acutely to the pharmacological or toxicological actions of cocaine. Medicinal Chemistry
Research, 4:93-110, 1994.
92.
Calderon, S.N., Izenwasser, S., Heller, B., Gutkind, J.S., Mattson, M., Su, T.-P. and
Newman, A.H. Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and
selective sigma1 ligands. J. Med. Chem., 37:2285-2291, 1994.
93.
Newman, A.H., Allen, A.C., Izenwasser, S., and Katz, J.L. Novel 3diphenylmethoxytropane analogs are potent dopamine uptake inhibitors without cocainelike behavioral profiles. J. Med. Chem., 37:2258-2261, 1994.
94.
Izenwasser, S. and Katz, J.L. 7-OH-DPAT antagonizes dopamine D2 receptor-inhibited
adenylyl cyclase activity. Life Sciences/Pharmacol. Letters, 55:PL257-259, 1994.
95.
Izenwasser, S., Terry, P., Heller, B., Witkin, J.M., and Katz, J.L. Differential relationships
among dopamine transporter affinities and stimulant potencies of various uptake inhibitors.
Eur. J. Pharmacol., 263:277-283, 1994.
96.
Kelkar, S.V., Izenwasser, S., Katz, J.L., Klein, C.L., and Trudell, M.L. Synthesis, cocaine
receptor affinity and dopamine uptake inhibition of several new 2-substituted 3 phenyltropanes. J. Med. Chem., 37:3875-3877, 1994.
97.
Izenwasser, S., Rosenberger, J.G. and Cox, B.M. The cocaine analog WIN 35,428 binds to
two sites in fresh rat caudate-putamen: significance of assay procedures. Life
Sciences/Pharmacology Letters, 52:PL141-145, 1993.
98.
Izenwasser, S. and Katz, J.L. Differential efficacies of dopamine D1 receptor agonists for
stimulating adenylyl cyclase activity in squirrel monkey and rat. Eur. J. Pharmacol. - Mol.
Pharmacol. Sect., 246:39-44, 1993.
99.
Unterwald, E.M., Cox, B.M., Kreek, M.J., Cote, T.E. and Izenwasser, S. Chronic repeated
cocaine administration alters basal and opioid-regulated adenylyl cyclase activity. Synapse,
15:33-38, 1993.
100. Izenwasser, S. Buzas, B. and Cox, B.M. Differential regulation of adenylyl cyclase activity
by mu- and delta- opioids in rat caudate-putamen and nucleus accumbens. J. Pharmacol.
Exp. Ther., 267:145-152,1993.
101. Cote, T.E., Izenwasser, S. and Weems, H.B. Naltrexone-induced upregulation of µ-opioid
receptors on 7315c cell and brain membranes: enhancement of opioid efficacy in inhibiting
adenylyl cyclase. J. Pharmacol. Exp. Ther., 267:238-244, 1993.
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102. Izenwasser, S., Newman, A.H. and Katz, J.L. Cocaine and several sigma receptor ligands
inhibit dopamine uptake in rat caudate-putamen. Eur. J. Pharmacol., 243:201-205, 1993.
103. Izenwasser, S., Rosenberger, J.G. and Cox, B.M. Inhibition of [3H]dopamine and
[3H]serotonin uptake by cocaine: Comparison between chopped tissue slices and
synaptosomes. Life Sciences, 50:541-547, 1992.
104. Izenwasser, S. and Cox, B.M. Inhibition of dopamine uptake by cocaine and nicotine:
Tolerance to chronic treatments. Brain Research, 573:119-125, 1992.
105. Izenwasser, S., Jacocks, H.M., Rosenberger, J.G., and Cox, B.M. Nicotine indirectly inhibits
[3H]dopamine uptake at concentrations which do not directly promote [3H]dopamine release
in rat striatum. J. Neurochemistry, 56:603-610, 1991.
106. Jacocks, H.M., Izenwasser, S., Werling, L.L., and Cox, B.M. Comparison of dopamine
uptake and release in vitro in sheep and rat striatum. Life Sciences, 49:481-488, 1991.
107. Izenwasser, S., Werling, L.L., Rosenberger, J.G., and Cox, B.M. Characterization of binding
of [3H]GBR 12935 to membranes and to solubilized membrane extracts from terminal field
regions of mesolimbic, mesocortical and nigrostriatal dopamine pathways.
Neuropharmacology, 29:1017-1024, 1990.
108. Izenwasser, S. and Cox, B.M. Daily cocaine treatment reduces [3H]dopamine uptake in vitro
in rat nucleus accumbens but not in striatum. Brain Research, 531:338-341, 1990.
109. Izenwasser, S., Werling, L.L., and Cox, B.M. Comparison of the effects of cocaine and
other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle,
and medial prefrontal cortex. Brain Research, 520:303-309, 1990.
110. Izenwasser, S. and Kornetsky, C. Effects of clonidine and yohimbine alone and in
combination with morphine on supraspinal analgesia. Neuropharmacology, 29:25-29,
1990.
111. Izenwasser, S. and Kornetsky, C. Effects of amfonelic acid or nisoxetine, alone and in
combination with morphine on brain-stimulation reward. Pharmacology, Biochemistry and
Behavior, 32:983-986, 1989.
112. Izenwasser, S., Blake, M.J., Goeders, N.E. and Dworkin, S.I. Punishment modifies the
effects of chlordiazepoxide and benzodiazepine receptors. Pharmacology, Biochemistry
and Behavior, 32:743-748, 1989.
113. Izenwasser, S. and Kornetsky, C. Potentiation of morphine analgesia by d-amphetamine is
mediated by norepinephrine and not dopamine. Pain, 33:363-368, 1988.
114. Izenwasser, S.E. and Kornetsky, C. Pharmacological effects of morphine on brainstimulation reward. Psychopharmacology, 93:136-137, 1987.
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115. Izenwasser, S.E., Garcia-Valdez, K., and Kantak, K.M. Stimulant-like effects of
magnesium on aggression in rats. Pharmacology, Biochemistry and Behavior, 25:11951199, 1986.
Other works:
Patent:
Newman, A. H., Allen, A. C., Kline, R. H., Izenwasser, S., Katz, J. L., 4' and 4',4"Substituted-3-(Diphenylmethoxy) Tropane Analogs as Cocaine Therapeutics, U.S.
Patent # 5,792,775, filed June 20, 1996, awarded August 11, 1998.
Honors and Awards:
Outstanding Mentor of 2003/2004 Siemens Westinghouse Competition in Math, Science &
Technology Winner
Joseph Cochin Young Investigator Award, College on Problems of Drug Dependence, 1999.
National Research Council (National Academy of Sciences) Associateship, 1992-1993
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