Noesis Chemoinformatics
Chemoinformatics, bioinformatics
Contact person details
Name:
NICOLAOU , Christos
Position:
CsO
Name of
Organisation:
Noesis Chemoinformatics
URL:
E-mail:
Contact
Telephone:
+357-22-795000
Fax number:
+357-22-772616
Collaboration
Type: Company Expertise
Title: Chemoinformatics, bioinformatics
Participation: Type A
Type Details: Our mission is to assist human experts in their effort to comprehend
the mechanism of action of ligand-receptor complexes and support them during the
process of lead optimization, specifically in deciding which compounds to select,
synthesize and test in later rounds of screening.
To fulfill its mission Noesis develops proprietary data analysis software that:
1. Extracts knowledge from chemical and biological data produced during the drug
discovery process with emphasis on the lead optimization phase;
2. Applies that knowledge to improve the design of downstream drug discovery
experiments;
3. Presents that knowledge in a format easily understood by human experts.
Noesis' software identifies the relationships between chemical structures and
multiple biological properties and formulates rules describing biological behavior. The
resulting knowledge is used to design molecular libraries and computationally
synthesize novel compounds that satisfy multiple biological, chemical as well as
other user-defined constraints while covering the biological/pharmacological space of
interest.
The core information technology is developed by combining knowledge extraction
and optimization (mono and multi-objective) algorithms with traditional statistical
methods and analytical techniques. Among others, Noesis employs chemical
substructure mining and scaffold extraction, experimental design and multi-objective
optimization techniques to fulfill its objectives.
Noesis' methodology produces screening collections with compounds (real or virtual)
of improved pharmacological profile (lead-like) and thus, increases the chance of
resulting hits surviving further preclinical development.
Programme: ASIA-ITC , FP7 , FP7-HEALTH , FP7-ICT
Instruments: NoE Networks of Excellence,CP-FP Small or medium-scale focused
research project
Research interest:
Expiry Date: 2009-05-30
Workprogramme area(s)/key action(s):
(FP7-HEALTH HEALTH-2007-2.1.1) Large scale data gathering
(FP7-HEALTH HEALTH-1.1) High-throughput research
(FP7-HEALTH HEALTH-2007-2.1) Integrating biological data and processes: largescale data gathering, systems biology
(FP7-HEALTH HEALTH-2007-1.3) Predicting suitability, safety and efficacy of
therapies
(FP7-HEALTH HEALTH-1) Biotechnology, generic tools and medical technologies for
human health
(FP7-ICT ICT-2007.4) Digital libraries and content
(FP7-HEALTH HEALTH-2007-1.4) Innovative therapeutic approaches and
interventions
(FP7-ICT ICT-2007.5.2) Advanced ICT for risk assessment and patient safety
(FP7-HEALTH HEALTH-2007-3.1) Translating the results of clinical research outcome
into clinical practice including better use of medicines, and appropriate use of
behavioural and organisational interventions and new health therapies and
technologies
(FP7-ICT ICT-2007.5) Towards sustainable and personalised healthcare
(FP7-ICT ICT-2007.4.4) Intelligent content and semantics (ICT-2007.4.4)
(FP7-ICT ICT-2007.4.3) Digital libraries and technology-enhanced learning (ICT2007.4.3)
(FP7-ICT ICT-2007.4.1) Digital libraries and technology-enhanced learning
(FP7-ICT ICT-2007.4.2) Intelligent content and semantics (ICT-2007.4.2)
Target Partner
Expertise:
We are looking for partners that produce small molecule biological data and wish to
analyze their data to extract valuable knowledge that will guide their efforts for lead
optimization and design. This type of partners may come from the life sciences
industry as well as the cosmetics filed, the household chemicals industry, etc.
We are also looking for partners involved with the toxicology field to provide us with
data and expertise required for building computational models for toxicology
prediction.
A third category of potential partners is research organizations and software
companies involved with chemo/bio-informatics. We are open to collaborations with
this category of partners that will lead to the development of novel algorithms useful
in the quest for discovery of knowledge in chemical and biological data.
Country: Österreich, Belgique-België, Schweiz/Suisse/Svizzera, Ceska Republika,
Deutschland, Danmark, Eesti, España, Suomi/Finland, France, United Kingdom,
Hellas, Magyarorszag, Éire/Ireland, Ísland, Italia, Lietuva, Luxembourg (GrandDuché), Latvija, Malta, Nederland, Polska, Portugal, Sverige, Slovenija, Slovenska
Republika
Organization Details
Name:
Noesis Chemoinformatics
Department:
Address:
Metochiou 66
Engomi-2407
Cyprus
2407
Nicosia
KYPROS/KIBRIS
Type:
Research, SME (Small or Medium sized Enterprise)
Number of
Employees:
< 10
Details:
SIC Codes:
Biotechnology , Environmental Protection , Industrial biotech ,
Information and communication technology applications , Life
Sciences
Keywords:
Chemoinformatics, bioinformatics, knowledge extraction, data
mining, multiobjective optimization, predictive modeling
Partners already
acquired: