Partners Research Studies Seeking Volunteers 1. Are you depressed? Have you stopped getting your period? For more information contact Janet Lydecker at (617) 724-1838 or jlydecker@partners.org. Women who are currently depressed and have not had their period for at least three months are needed for a research study at Massachusetts General Hospital. Participants cannot be on oral contraceptive (birth control) pills, and must be 18-45. The study looks at the role of cortisol and other hormones on bone health. Study participants will come to Massachusetts General Hospital for three visits: two outpatient visits, and one overnight stay. Research participants receive a physical examination, nutritional and body composition analyses, hormonal evaluation, and bone density information at no cost. Participants also receive reimbursement of local travel/ parking costs, as well as up to $150 for their participation. 2. Can Salt Affect the Blood Vessels? Brigham and Women’s Hospital is investigating the effect of salt on blood vessel function. We seek healthy men 18-45 years old. This research study will last about 3 weeks and involves a few overnight stays in the hospital, blood sampling, meals, and blood vessel testing. Compensation up to $500. Contact: Ffyona 617-278-0672. 3. Post-Pregnancy Research Study Brigham and Women’s Hospital, Endocrine-Hypertension Division, seeks women who have had pregnancies complicated by high blood pressure in the past 10 years. Participants cannot be currently pregnant. Research study includes an oral glucose tolerance test, fasting blood tests and two non-invasive vascular studies. Takes about 5 ½ hours. Stipend. Call the Study Coordinator at: 617-732-8538 or email zabdulrahim@partners.org 4. Smoking Cessation and Relapse Prevention Research Study Do you want to quit smoking once and for all? Have you been smoking 10 or more cigarettes a day for the past 6 months? If you are a female between the ages of 18 and 65, you may be eligible to participate in our research study at no cost to you. The study involves an 8-week smoking cessation phase, where you will be given free nicotine patches to help you quit smoking. If you are able to successfully quit smoking after 7 weeks of nicotine replacement therapy (i.e. the patch), you will enter into the 5-week relapse prevention phase of the study where you will stop using the patch, and you will be randomly assigned to receive an investigational drug that may be an effective treatment in helping prevent recently quit smokers from relapsing or placebo (i.e. inactive medication). Posted 3/5/08 Study participation involves weekly or biweekly visits to our clinic at Massachusetts General Hospital and the completion of computerized and behavioral tasks at three points throughout the 15-week study. Additional compensation will be provided. If interested, please call 617-724-8472 or email quitforgood@partners.org. All inquiries are completely confidential. 5. Do you think you might be at risk for diabetes? Does anyone in your family have diabetes? Are you overweight? If you are interested in participating in a new research study…We need your help! The Center for Human Genetic Research at Massachusetts General Hospital seeks men and women over the age of 18 who are NOT currently on diabetes medication for a research study exploring the influence of genetic background on the response to established type 2 diabetes treatments. Participants will be asked to visit the hospital twice in seven days. The total time commitment is five hours for the first visit and three hours for the second visit. Compensation will be provided up to $100 plus two $5 transportation vouchers and a free meal. Contact Alicia at (617) 643-4985 or email amhernandez@partners.org 6. ARE YOU TAKING ATENOLOL or METOPROLOL TO MANAGE HIGH BLOOD PRESSURE? You may be eligible to participate in a research study at Brigham and Women’s Hospital to see if melatonin supplementation can help lower your blood pressure. Earn up to $ 2 , 0 0 0 . 0 0 if you are: 35-65 years of age Taking at least 50 mg of Atenolol or at least 100 mg of Metoprolol per day Otherwise healthy - Participants will undergo a medical screening, including a sleep screen, which can take up to 3 weeks. - After the screening, the study will take approximately 6 weeks during which you will spend two separate four-day stays at our facility at Brigham and Women's Hospital to monitor sleep, blood pressure, and various hormones. Contact Carolina at 617-278-0662 or csmales@rics.bwh.harvard.edu for more information 7. Healthy Volunteers needed for research study on Inflammatory Bowel Disease (IBD) Are you scheduled for a screening colonoscopy at MGH? Massachusetts General Hospital, Crohn’s and Colitis Center, seeks healthy volunteers, ages 18 years and older, for a research study to increase understanding and learn more about what may cause IBD and what factors influence the course of IBD over time. We also need to study healthy volunteers who do not have IBD. Posted 3/5/08 Participants should be able and willing to provide blood samples and should not have any other immune mediated diseases, such as asthma, psoriasis, rheumatoid arthritis, lupus or multiple sclerosis. This study involves only 1 study visit, which consists of a brief physical examination and interview, a urine sample, questionnaires, and a blood draw for approximately 1½ tablespoons of blood. You will be given $25 for the study visit. For more information, please contact Melissa at (617) 724-3238 or mcohen4@partners.org 8. Healthy Volunteers needed for a study on chronic sinusitis: We are seeking healthy volunteers without secondhand smoke exposure for a research study to learn more about chronic sinusitis. You may be eligible if you: 1) are between 21-70 years old; 2) are in good health, 3) have never smoked, and 4) do not have: nasal or sinus disease, allergic rhinitis, asthma, previous sinus surgery, or ongoing exposure to animals. Compensation up to $295. For more information, please contact Rachel at 617726-6376 or rharold@partners.org. 9. Do You Have Asthma? The Asthma Research Center at Brigham and Women’s Hospital is recruiting asthmatics aged 18-75 who use asthma medication to control their asthma symptoms. The research study involves 13 visits (2.5hrs) over a 13-week period. The study is looking at how inhaled medicine, albuterol and placebo (contains no active medication) and acupuncture improve lung function. Participants are compensated up to $750.00 at the end of the research study, if all visits are completed. If interested, please call us at 1-888-99ASTHMA or email us at ARC@PARTNERS.ORG for more information. 10. Seeking men and women diagnosed with schizophrenia Researchers from the Massachusetts General Hospital, Psychiatry Department seek men and women ages 18-65 that have a diagnosis of schizophrenia or schizoaffective disorder and are treated with clozapine (clozaril). This twelve week research study examines the effects of aripiprazole, an antipsychotic medication, on lipid and glucose metabolism, as well as body composition when added to clozapine. We are interested in learning whether aripiprazole improves how the body manages blood sugar and/or decreases cholesterol and triglycerides and thereby decreases the risk of diabetes and cardiovascular disease in subjects receiving clozapine treatment. Participants are compensated up to $190. If interested, please call Elizabeth at (617) 912-7837 or e-mail ecarpino@partners.org. 11. Seeking men and women diagnosed with schizophrenia Researchers from the Massachusetts General Hospital, Psychiatry Department seek men and women ages 18-65 that have a diagnosis of schizophrenia or schizoaffective disorder and are treated with antipsychotic medications. This twelve-week research study examines the effects of ramelteon, a sleep aide medication, on waist circumference, stomach fat, as well as body composition when added to antipsychotic medications. We are interested in learning whether ramelteon improves how the body manages insulin levels, decreases waist circumference and stomach fat, and thereby decreases the risk of Posted 3/5/08 diabetes and cardiovascular disease. Participants are compensated up to $190. If interested, please call Elizabeth at 617/912-7837 or email ecarpino@partners.org. Posted 3/5/08