Conference “Biomedical Engineering“ Electronic means used in sleep medicine. A review Raul Kala Member of Estonian Sleep Medicine Association, Estonia E-mail: raulkala@gmail.com Introduction. Today's sleep medicine technology relies on electronics and therefore it is appropriate to talk about electronical sleep medicine devices. Since Hans Berger's brain electroencephalographic recordings in 1924 [1], electronic sleep medicine technologies have evolved fast, and have turned into a complex field of science. Diagnosis and therapy of more than 80 different sleep disorders need specific devices [2]. Considering the vast amount of different electronic sleep medicine devices nowadays, there is an obvious need for an overview. Classification of the sleep devices. Classification of the sleep devices is vague because many classes of the devices have overlappings with the others. Contemporary electronic devices have become very complex, and thus cannot be distinguished by working principle. However, some kind of classification of the electronic sleep medicine technology devices is possible to accomplish. In Fig. 1 is presented a patient based Sleep disorder approach, which shows patient the use of the sleep medicine devices according to the needs. Visite to the doctor In this short overview the sleep Choosing the appropriate method(s) of diagnosing medicine devices are Image Online sleep Wearable Beds and PSG DASS devices diaries devices pillows devided into 6 classes as seen below. Determining the cause of the disease - diagnostic devices, - therapeutic devices, Choosing the appropriate method(s) of theraphy - wearable devices, - image devices, CPAP BiLevel LAUP UAS - beds and pillows - online sleep diaries. Curing process In the following sections these 6 NO Is the patient satisfied classes of electronic with the results ? sleep medicine deYES vices are described in Patient cured more details Fig. 1. A patient based approach of the use of the electronic sleep medicine devices 1 Conference “Biomedical Engineering“ Electronic diagnostic devices. In sleep medicine the main electronic diagnostic devices are polysomnographs and fatigue evaluation devices DASS. Polysomnograph (PSG). The main electronic diagnostic device in sleep medicine is polysomnograph, a device measuring the variation of many parameters during sleep. Minimum requirement for polysomnographic recording is simultaneous recording of EEG, EMG and EOG. During polysomnographic recording breathing, ECG, snoring sound, temperature and hemoglobin oxygen supply signals can be additionally recorded. DASS (Depression Anexity and Stress Scale) is a car driving simulation system, which is used for assessing the patient's fatigue. During the DASS study the patient is asked to drive a car in a simulator, following the road appearing on the simulator’s screen. The patient's ability to endure monotonous activities, response of speed, and sleep-specific brain activity signals are measured by the signals from the electrodes placed on the patient’s head [3]. Electronic therapeutic devices. At present there are four electronic sleep medicine devices, which can be classified as therapeutic devices – the continuous positive airway pressure CPAP device, BiLevel, LAUP and UAS devices. CPAP. Continuous Positive Airway Pressure (CPAP) device was introduced by Gregory et al. [4] in 1971. The CPAP is a nonivasive device that provides ventilation using constant positive airway pressure by blowing the air through the mask into the patient’s airways, thus avoiding the appearance of the symptoms of apnoe. Since patients may experience a dry mouth, there exist also devices, which moisturizes the air blown into the patient’s airways with a heated humidifier. BiLevel. In addition to the creating of continuous air pressure, as it is produced by the CPAP devices, the BiLevel noninvasive air pressure devices create two different levels of positive air pressure. The level of pressure of air increases when the patient breathes in, and decreases when the patient breathes out [5]. This property of the BiLevel devices allows the pressure creating devices to be used also by these patients who cannot use the CPAP. LAUP (Laser-Assisted Uvulopalato-plasty). In 1990 a new anti-snoring procedure called LAUP was introduced in France. LAUP is a therapeutic procedure during which after the implementation of sedation, the CO2 laser is used to reduce the size of the palate and uvula. Regardless of surgical operation of laryngeal tissue, the LAUP procedure can be accomplished repeatedly [6]. UAS. (Upper Airway Stimulation) is a device of the company Inspire, which uses the electrical stimulation of the hypoglossal nerve to prevent obstructive apnoe [7]. The device consists of implantable pressure sensor, pulse generator and stimulation electrode. The pulse generator is needed for processing information from the pressure sensor and to find the most beneficial time to deliver the electrostimulation [7]. Wearable electronic devices. In sleep medicine wearable medical electronic devices allow to notice the progression of the disease at an early stage and to monitor subsequent course of treatment changes. Wearable electronic devices find primarily use as ribbon-mounted headsets, actigraphs and vests. 2 Conference “Biomedical Engineering“ A headset is a data acquisition device, worn ribbon-mounted on patient's head. The main advantage of the use of the headset is its ability to measure the EEG signals [8]. If needed, additional electrodes can be added. Vests allow to measure breathing activity, ECG, temperature of the body, and much more [9]. Electronic vests, used as body area data aquisition systems, allow long term measurement of patient's activity inside and outside the bed. Actigraphs are small sized wrist worn devices for recording movement activity. They were probably taken into use as early as in 1972 [10]. There are two types of actigraphic devices: accelerometric and multi-sensor devices. Image acquisition devices. For the acquisition of patient's sleep time image and health status mainly thermographic IR and video recordings are used in sleep medicine [11]. Specially equipped beds and pillows. This is a new branch of electronic sleep medicine devices, which has come out with beds and pillows, supplied with electronic devices. Electronic pillows. Today the pillows enriched with electronic devices are able to detect snoring and sing lullabies [12]. Company Philips has created a system consisting of a pillow and a flax that monitors patient's heart status [12]. Electronic beds. The 1987 report of Honeywell Corporation stated that people are eating, working and watching TV in bed. Accordingly, the TV, positioning systems and much more were added to the bed. After 1988 Honeywell and Microsoft Corporation conducted research on beds, and it became evident that electronic beds are an integral part of our lives [13]. Possibly the most innovative electronic bed is a capsule created by Matsushita Electric Works. Inside the capsule is created the environment for sleepiness and alertness [14]. Online sleep diaries. The use of online sleep diaries helps to create a more efficiently working internet environment between the doctor and the patient. Traditionally used sleep diaries are not very efficient because data entries on paper are not exact. Online sleep diaries help to stamp the time of the sleep events and to show many interesting medical characteristics. Therefore it is important to understand that online sleep diaries are an integral part of modern electronic means used in sleep medicine [15]. Conclusion. Electronic sleep medicine devices are highly complex and in most cases the use of these devices need highly skilled personnel. Costs of such personnel are high and with the help of modern electronic technologies it is more convenient to use devices that the patient can handle himself. Therefore only some electronic sleep medicine devices remain in the hospital use. The patient uses many different devices for diagnosing and cure of his health with data being mostly transferred to the doctor via internet. In such cases the patient will be surrounded with electronic body area networks and smart home appliances such as electronic beds and pillows. In conclusion it can be said that in the future the new electronic sleep medicine devices will be more complex, smaller in size, easier to use and cheaper to buy. 3 Conference “Biomedical Engineering“ References 1. Collura T. F. History and Evolution of Electro-encephalographic Instruments and Techniques // Journal of Clinical Neurophys., 1993, vol. 10, no. 4. – P. 476–504. 2. Fisher J. Sleep disorders, social and traffic accidents. 20 years experiences of German sleep medicine // Eesti Arst, Lisa 10, 2007. – P. 6. (in Estonian) 3. Veldi M. Uneraamat (A book of sleep) // Lege Artis, Tallinn, Estonia, 2009 (in Estonian). 4. Bohlin K., Jonsson B., Gustafsson A.-S. Blennow M. Continuous Positive Airway Pressure and Surfactant // Neonatology, 2008, vol. 93. – P. 309–315. 5. Antonescu-Turcu A. and Parthasarathy S. CPAP and Bi-level PAP Therapy: New and Established Roles // Respiratory Care, 2010, vol. 55, No. 9, Sept. P.1216–1229. 6. Strauss R. A. Lasers in the management of snoring and mild sleep apnea // Oral Maxillofacial Surg Clin N Am, 2002, 14. – P. 319–331. 7. Keelenärvi elektrostimulatsioon. (Hypoglassal nerve electrostimulation) URL: http://www.inspiresleep.com/ (in Estonian) 8. Brown L., Molengraft J., Yazicioglu R. F, Torfs T., Penders J., Hoof C. V. A low-power, wireless, 8-channel EEG monitoring headset // Conf Proc IEEE Eng Med Biol Soc. 2010. – P. 4197-200. 9. Loriga G., Taccini N., De Rossi D. Textile Sensing Interfaces for Cardiopulmonary Signs Monitoring // Proceedings of the 2005 IEEE Engineering in Medicine and Biology 27th Annual Conf., Shanghai, China, Sept 1-4, 2005. P. 1-4. 10. Tryon W.W. Issues of validity in actigraphic sleep assessment // Sleep, 2004, vol. 27, No. 1. P. 158-165. 11. Murthy J.N., van Jaarsveld J., Fei J., Pavlidis I., Harrykissoon R.I., Lucke J.F., Faiz S., Castriotta R. J. Thermal Infrared Imaging: A Novel Method to Monitor Airflow During Polysomnography // Sleep, 2009, vol. 32, No. 11. P. 1521-1527. 12. Kala R. Lühiülevaade elektroonilistest patjadest ning nende kasutamisest Eestis ja välismaal (A short overview about the usage of electronic pillows in Estonia and abroad)// Arvutid ja Andmetöötlus., 2011, vol. 1, No. 11. – P. 19-22. (in Estonian) 13. Crick M. The Future Of Beds, URL: http://www.beds-uk.org.uk/ futureofbeds.asp 14. Coleman J. Sleep room featuring sounds, images, massage opens in Japan // The Associated Press URL: http://community.seattletimes.nwsource.com/archive/?date= 20040613&slug=sleep13, 30.06.2011. 15. Blake J., Kerr D. Development of an Online Sleep Diary for Physician and Patient Use // Knowledge Management & E-Learning: An International Journal, 2010, Vol. 2, No. 2. P. 188-202. Electronic means used in sleep medicine. A review R. Kala Member of Estonian Sleep Medicine Association, Estonia Today's sleep medicine technology relies on electronics and therefore it is appropriate to talk about electronical sleep medicine devices. Electronic sleep medicine technologies have evolved fast, and have turned into a complex field of science. Today electronic devices have become so complex that devices cannot be distinguished only by the working principle. Additional measures have to be taken. Here a patient based approcah of classification of electronic sleep medicine devices is presented. 4