Partners Research Studies Seeking Volunteers 1. Is your face red, flushing, or look like it has adult acne? You may have ROSACEA and may be eligible for participation in a research study Please contact us at 617-726-5066 or harvardskinstudies@partners.org Compensation of $25 1 or 2 study visits over 2 weeks Must be 18 years or older IRB # 2007-P-011671 2. Parenting with Cancer Focus Group Do you have children 18 years of age or under? Are you concerned about the way your cancer is affecting your family? The Cancer Center Parenting Program (PACT) will be conducting focus groups by phone to learn about your parenting concerns and how a parent’s cancer is affecting your family life. Focus groups of 4-6 people each will meet on a conference call for 1 - 1½ hours to discuss concerns about parenting with cancer. You may also be asked to offer feedback on a questionnaire that assesses parenting concerns. For more information on this research project and to find out how you can participate, please contact Joel Villanueva at (617) 726-1604 or at jvillanueva1@partners.org Protocol #: 2006-P-001782 3. Are you taking medication for bipolar disorder and experiencing sexual side effects? If you are a female, aged 18-80 and experiencing sexual dysfunction due to psychotropic medications for bipolar disorder, you may be eligible to participate at no cost to you in a 12-week research study of a natural compound called Maca Root. Maca Root has been used for centuries in South America for nutritional and medicinal purposes. This study is designed to determine whether Maca Root is effective in the treatment of sexual dysfunction associated with the treatment regimen for bipolar disorder. If interested, please call 877-552-5837. All inquiries will be completely confidential. IRB#: 2007-P-001471 4. Wanted: Menopausal Women with or without Hot Flashes Dr. Seely of the Brigham and Women’s Division of Endocrinology, Diabetes and Hypertension is doing a 2-day study examining the heart and blood vessels of women who have hot flashes and women who do not have hot flashes. This study involves wearing a hot flash monitor, blood pressure monitor and heart rate monitor for 24 hours. Participants will be compensated up to $200 for their time. If you are a Menopausal Women between the Ages 46-55 with more than 4 hot flashes each day or without hot flashes, and you are interested in hearing more about this study, Please contact Zainab at (617-732-8538) IRB#2007P-001029 Posted 3/19/08 5. Do You Have Asthma? The Asthma Research Center at Brigham and Women’s Hospital is recruiting asthmatics aged 18-50 who use asthma medication to control their symptoms. The research study involves 12 visits over a 6-month period and involves bronchoscopies. The study’s purpose is to assess the safety and effectiveness of a new medication in the treatment of asthma. Compensation up to $1650 will be provided at the end of participation. Call us at 617-732-8259 or 1-888-99ASTHMA for more information. IRB#2007-P-001797 6. Comparison of Lantus and NPH Insulin in the Dawn Phenomenon Massachusetts General Hospital, Diabetes Research Center, seeks individuals with Type 1 diabetes for a research study to better understand how two different types of longacting insulin affect blood sugar control during the early morning hours. Study involves: 1. Three daytime outpatient visits at the Diabetes Research Center, including nutritional counseling, teaching of Continuous Glucose Monitoring System (CGMS). 2. Two overnight inpatient hospital stays during which blood samples will be obtained through an intravenous (in the vein) line. Study requirements: Candidates must have Type 1 diabetes for 5 or more years, be between the ages of 18-60, and must use either glargine (Lantus) or NPH insulin. Compensation: Up to $220. All tests and alternate insulins provided at no cost. For more info: Christine Stevens RN, study coordinator at 617643-0915. IRB# 2005-P-002515 7. PMS and Depression Study Seeking women between 18-45 with PMS who have been diagnosed with depression. If you are between 18 and 45 and: Suffer with PMS Currently being treated with an antidepressant You may be eligible for a research study at Massachusetts General Hospital evaluating how a birth control helps with premenstrual mood symptoms. Women who participate will receive study medication and evaluations of their mood at no cost, and will be compensated up to $450. For information, please call: (617) 724-6540 or email afarrell2@partners.org IRB# 2007-P-002057 8. Healthy Volunteers Wanted for HIV Vaccine Research Study Brigham and Women's Hospital researchers are looking for healthy men and women to participate in HIV Research Studies. You may be eligible to participate in one of the investigational, preventative studies currently being conducted, if you meet the following criteria: HIV negative adult 18-50 years in age In good health All participants receive counseling and testing at no cost. Compensation is also provided. FACT: You cannot get HIV from participating in an HIV Vaccine Research Study. Posted 3/19/08 Call and volunteer today @ 617-525-7327 or email vaccines@partners.org. For additional information, please visit www.hvtn.org IRB# 2002-P-000343 9. OVERWEIGHT? You may have High Blood Pressure Men and women who are overweight are at greater risk for High Blood Pressure and High Blood Sugar. You may qualify to take part in a clinical research study at Brigham and Women’s Hospital. The main purpose of this study is to see if an approved blood pressure drug can improve your blood sugar. You may qualify IF you: Are between 18 and 75 years old Are overweight Do not have diabetes Do not take more than one medicine for high blood pressure Are able to attend 5-6 visits at Brigham and Women’s Hospital Qualified participants will receive (at no cost): Screening for high blood pressure, diabetes and high cholesterol Physical examination Research medication Modest compensation and reimbursement of parking/public transportation costs For more information or to schedule a screening appointment (to see if you are eligible), call the Vascular Medicine Research Center at (617) 525-7055. IRB# 2007-P-000490 10. Women with anorexia nervosa who are 18-45 years old and have not had their period for at least 3 months, are needed for a research study at Massachusetts General Hospital looking at the role of cortisol and other hormones on skeletal health. Participants cannot be on oral contraceptive pills. The study includes an hour-long screening session, a two-hour outpatient visit and a 24-hour inpatient stay. Participants receive a physical examination, nutritional and body composition analyses, and a hormonal evaluation, as well as bone density, blood, urine and saliva tests at no cost. For more information contact Janet Lydecker at (617) 724-1838 or jlydecker@partners.org. Volunteers also receive up to $150 for their participation, as well as reimbursement of local travel/ parking costs. IRB# 2003-P-000549 11. Healthy Subjects Who Have Experienced Trauma Wanted For A Study of Brain Activity in People with Posttraumatic Stress Disorder (PTSD) Dr. Lisa Shin and colleagues in the Department of Psychiatry at the Massachusetts General Hospital (MGH) are conducting a research study to examine brain activity in individuals who have posttraumatic stress disorder (PTSD), as compared to those who do not have PTSD. We are seeking healthy comparison subjects who have experienced traumatic events in the past. Participation will take up to 5 hours of your time. It will involve undergoing a psychiatric assessment, filling out questionnaires, providing a saliva sample, and lying in a scanner while “pictures” of your brain are taken using functional magnetic resonance imaging (fMRI). Participants will be paid $100 for their time. Posted 3/19/08 Who is Eligible: Individuals who are: Age 18-45 Right-Handed Not Pregnant Without metal implants, such as pacemakers and aneurysm clips For more information: Please contact Lisa M. Shin, PhD at (617) 726-8120IRB# 2006-P000579/4 12. Do you want to know how your pregnancy, blood sugar, and heart are related? The Endocrinology, Diabetes, and Hypertension Division of Brigham and Women’s Hospital seeks healthy Black women 18-40 years old who have had normal pregnancies or pregnancies complicated by diabetes in the past 5 years for a research study on diabetes during pregnancy and its effects on heart disease risk. The research study includes an oral glucose tolerance test, fasting blood tests and a non-invasive vascular study. Participants cannot be currently pregnant or nursing. Takes about 5 hours. Stipend is $100. Principal Investigator: Rhonda Bentley-Lewis, MD, MBA, MMSc Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital If interested, please call Ffyona at 617-278-0672 or e-mail at fpatel1@partners.org. IRB# 2007-P-001406 13. Seeking men and women diagnosed with schizophrenia: Researchers from the Massachusetts General Hospital, Psychiatry Department seek men and women ages 18-65 that have a diagnosis of schizophrenia or schizoaffective disorder and are treated with clozapine (clozaril). This twelve week research study examines the effects of aripiprazole, an antipsychotic medication, on lipid and glucose metabolism, as well as body composition when added to clozapine. We are interested in learning whether aripiprazole improves how the body manages blood sugar and/or decreases cholesterol and triglycerides and thereby decreases the risk of diabetes and cardiovascular disease in subjects receiving clozapine treatment. Participants are compensated up to $190. If interested, please call Elizabeth at (617) 912-7837 or e-mail ecarpino@partners.org. IRB#: 2004-P-001611/25; MGH 14. Seeking Boys and Girls with Major Depression and Healthy Boys and Girls 1218 years old for a Research Study Includes bone density, blood draws and nutritional evaluation at no cost. One to four visits to Massachusetts General Hospital Up to $250 remuneration and parking offered. Please contact Nara Mendes at 617-724-6046 or nmendes1@partners.org The Neuroendocrine Unit at Massachusetts General Hospital. IRB# 2006-P-002441 Posted 3/19/08 15. Do you have a Wart? You may qualify for a research study on an Investigational device Age 18-55 years of age Up to 8 study visits Remuneration of $40 per study visit Please call (617) 726-5066 or e-mail us at: harvardskinstudies@partners.org IRB # - 2006-P-001911 16. Post-Pregnancy Research Study. Brigham and Women’s Hospital, Endocrine-Hypertension Division, seeks women who have had pregnancies complicated by high blood pressure in the past 10 years. Participants cannot be currently pregnant. Research study includes an oral glucose tolerance test, fasting blood tests and two non-invasive vascular studies. Takes about 5 ½ hours. Stipend. Call the Study Coordinator at: 617-732-8538 or email zabdulrahim@partners.org IRB# 1999-P-001601 Posted 3/19/08