Initial: _____ June 27, 2009
Curriculum Vitae
MAMDOOH GHONEUM, Ph.D.
Dr. Ghoneum is currently Associate Professor and Chief of Research at Charles Drew
University of Medicine and Science, Department of Otolaryngology, Head and Neck Surgery,
Los Angeles, CA. He is also Research Associate at Department of Neurobiology, School of
Medicine, University of California Los Angeles (UCLA). Dr. Ghoneum earned his Ph.D. at the
University of Tokyo, Japan in the field of radioimmunology (1976-1980) and did his
postdoctoral at UCLA, School of Medicine (1983) in the field of cellular and molecular
immunology. He has published 90 articles and 130 abstracts, including 11 books in Japanese
and in English related to cancer immunology. He holds 3 patents for inventing 3 biological
response modifiers for the treatment of cancer. He currently serves on the Editorial Board of
the International Journal of Occupational Medicine, Immunology and Toxicology and Ejorsa
"Egyptain Journal of Radiation sciences and Application.” In addition to his expertise in
immune suppression by chemical carcinogens, aging and stress, Dr. Ghoneum is an
internationally recognized immunologist who is an expert in the area of Cancer Immune therapy.
Dr. Ghoneum’s contribution to immunotherapy is introducing and patenting several new nontoxic biological response modifiers (BRMs) that activate NK cells and induce apoptosis of
cancer cells. These BRMs include: arabinoxylan rice bran (MGN-3), marina crystal minerals
(MCM), active hemicellulose compound (AHCC), gross thymic extract (Thymax) etc. Results of
his studies have been published in several peer review journals and are currently applied in major
clinical trials around the world. He received several international awards from; The American
Cancer Society. 1993. Japan Functional Food Research Association (JAFRA) Tokyo, Japan.
2002. The Filipino-Chinese Medical Society. Manila, Phillipines, 2005. In 2007 he was
nominated for the annual $1 million prestigious Gotham Prize in Cancer Research. He
created a video to educate the public about a new cancer therapy. The video was created in
collaboration with Dr. Susan Kelly and Dr. Keith Norris. He had special accelerated promotion.
He has been awarded numerous research grants from NIH-MBRS and major research institutions
in Japan. He has been a reviewer for the NIH Study Section Member. He has been an organizer
for annual workshops between the Japanese Immunology Society and Drew University since
1990. He is a member of several Scientific Societies, including the American Association for
Cancer Research (AACR).
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Initial: _____ June 27, 2009
BIOGRAPHICAL SKETCH
MAMDOOH GHONEUM, D.Sc.
Associate Professor III
Chief of Research, Head & Neck Cancer
Department of Otolaryngology
Charles R. Drew University of Medicine and Science
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Summary of Research Accomplishments
Personal History
Education
Academic Appointments
Patents
Honors and Special Recognition
Honors and Special Recognition for Members in the Lab
Languages
Professional Activities:
A. Professional Associations
B. Editorial Services
C. Grant Reviewer
Committees at Drew University
University Services
Community Service
Research:
A. Current Active Support
B. Pending Support
B. Previous Support
Teaching/Supervision:
A. Postdoctoral Fellows
B. Masters and Ph.D.
C. Residents
D. Medical Students
E. Drew Magnate High School
Collaboration
Workshops Organized
International Conferences and Workshops Organized
Representative Presentations and Abstracts
Invited Lectures Seminars
Research Papers – Peer Reviewed
Books
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1.PERSONAL HISTORY
Business Address:
Charles Drew University of Medicine and Science
1621 E. 120th Street
Los Angeles, Ca 90059
Business Phone:
(323) 563-5952
(323) 563-5953 (voice mail)
Home Address:
3240 Kelton Ave.
Los Angeles, Ca 90034
Home Phone/Fax:
(310) 474-6724
Date of Birth:
May 1, 1950
Place of Birth:
Egypt
Citizenship:
USA
2.EDUCATION
B.S.-1973, Zoology (Zoology, Botany & Chemistry). Mansoura University, Egypt.
Postgraduate courses- 1974, Histochemistry, Radiobiology, Physiology, Embryology, Statistics.
Mansoura University,Egypt .
M.S.c.-1976, Physiology. Thesis entitled: Females sex hormones and protection from
gamma radiation effects on the metabolism in some
mammalian tissues. Mansoura University, Egypt.
Ph.D.- 1980, Radio Immunology. Thesis entitled: Morphological study on radiation effects on
the thymus in the fish Oryzias latipes. University of Tokyo, Japan.
Postdoctoral- 1983, Cellular Immunology.UCLA School of Medicine, Department of
Neurobiology (previously, Department of Anatomy and Cell
Biology)
3.ACADEMIC APPOINTMENTS
Research Associate
1983-present.
UCLA, Neurobiology Department
Associate Professor
and Res. Director
1985-present
Department of Otolaryngology, Head & Neck
Surgery, Charles Drew University Med. & Sci.
4. PATENTS:
2007 Yeast US Patent #5,821,219 (“Opioid antagonists and methods of their use”)
(J. Bunzow, O. Civelli, D.K. Grandy, J.E. Grisel, J.S. Mogil)
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5.HONORS AND SPECIAL RECOGNITION
1.
In 2007 he was nominated for the annual $1 million prestigious Gotham Prize in
Cancer Research.
2.
Plaque of Appreciation for investigating the role of immunotherapy in cancer from the
Filipino-Chinese Medical Society, Inc. I was the guest speaker at the 3rd Scientific
Meeting and 2nd Oncology Symposium at the Filipino-Chinese Medical Society. Manila,
Philippines. (July 18, 2005).
I was awarded this plaque (picture attached). The
conference was attended by major oncologists in the Philippines and medical doctors.
3.
House of Representatives, State of Tennessee, Nashville. Nathan Vaughn, 2nd District
State Representative. Certificate of appreciation in 2004 Alternative medicine seminar.
Kingsport, Tennessee. (April 10, 2004)
4.
Certificate of Participation in 2004 Alternative medicine seminar. Kingsport, Tennessee.
(April 10, 2004)
5.
Certificate of appreciation. In recognition of 20 years of service. Harry E. Douglas,111,
Interim President. Charles R. Drew University of Med.& Sci. April 1st, 2004
6.
The International Society for Predictive Oncology (ISPO). Certificate of Participation in
The 7th International Symposium on Predictive Oncology & Intervention Strategies. Nice,
France. February 7-10, 2004
7.
Selected for the prestigious International Scientist of the Year 2002 by the International
Biographical Centre (IBC) Cambridge, England. Mr. Jon Gifford, Editor in Chief of
IBC, (August 16, 2002)
8.
Certificate of Distinguished Achievement in Functional Food and Cancer Research from
JAFRA (Japan Functional Food Research Association) (March 5, 2002)
9.
Certificate of Appreciation and Acknowledgment from the Japanese Immunology Society
of Oriental Medicine (1996).
10.
Participated as judge in the 36th Annual California State Science Fair- Senior Projects.
(1993-1995)
11.
Certificate in recognition of interest in science, NIH. (April 1993)
12.
Certificate of Distinguished Achievement in Cancer Research from the American College
of Nutrition, Cancer Treatment Centers of America. (November 1992).
13.
Member of the National Council on Radiation Protection and Measurements, team of
nuclear radiation specialists to visit Russia and Ukraine. (Summer 1992)
14.
NIH MBRS Grant Award on the Effects of Environmental Chemicals on Natural Killer
Cells. Principal Investigator. Total award of $1 000 000. (1986-1995)
15.
Accelerated promotion, Assistant Professor I to III. (1987)
16.
Member of King/Drew Magnet Science Fair Judgment panel. (1986-1989)
17.
Certificate of Appreciation from LA Unified School District- King/Drew Medical
Magnet. (1985 and 1990)
18.
Received commendations from Frank F. Fasi, Mayor of Honolulu, Hawaii; Dukt T.
Kawasaki, Vice President, Hawaiian Senate; John Waihee, Lieutenant Governor, State of
Hawaii. (November 1985)
19.
Monbusho Scholarship from Japanese Education Foundation in Egypt. (1976-1980)
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6.HONORS AND SPECIAL RECOGNITION FOR MEMBERS IN THE LAB
1.
Melo Yap, student, Magnet High School. Received Honorable Mention. California
Science Fair. May 1999 and May 2000. Melo continued her research on BRMs and in
2001she received scholarship to study in England.
2.
First Place award California Sci. Fair. S. Elarabi & S. Sieng. For their science project
carried out in my lab under my supervision. (1996)
3.
Trang Vu and Maynard Concepcion. 2nd place award in California Science Fair. May
1996
4.
Majid Torabi, M.D. Certificate of Appreciation from the Los Angeles Society of
Otolaryngology- Head and Neck Surgery. March 29,1993
5.
2nd place award in County Science Fair Rodena Vatanparast. (out of 504 participants.).
May 2, 1993.
7.LANGUAGES
Arabic, English and Japanese (fluent); French and German (fair).
8.PROFESSIONAL ACTIVITIES
a) Professional Affiliations
1. American Association for Cancer Research (AACR)
2. Japanese Immunology Society of Oriental Medicine
3. Int. Soc. for the Study of Subtle Energies and Energy Medicine
4. Clinical Immunology Society (CIS)
5. Intl. Center for African-American & Asian Relation (ICAAAR)
6. California Museum of Science and Industry
7. Society of Natural Immunity
8. American Arab Scientific Society
9. Radiation Research Society
10. Developmental and Comparative. Immunology
11. Japanese Society of Ichthyology
Member 1992 
Member 1992 
Member 1996-1999
Member 1988-1999
Member 1996-1997
Member 1995-1997
Member 1985-1997
Member 1986-1991
Member 1985-1989
Member 1985-1989
Member 1983-1987
b) Editorial Services
1.
Editorial Board. Ejorsa: Egyptain Journal of Radiation Sciences and Application
(2006 - present).
2.
Editorial Board. Int. J. Occupational Med., Immunology and Toxicology (1996).
3.
Article Reviewer. J. Dev. Comp. Immunol. (1988).
c) Grant Reviewer
1. Small Business Innovative Research (SBIR) Grants- NIH. (November 1984)
2. NIH/MBRS Program, division of Research Resources, Special Review Section and
Site Visit Team. (1989).
9.COMMITTEES AT DREW UNIVERSITY MED & SCI
1.
Space Committee. Drew University Med & Sci (1986-1992).
2.
Committee for Protection of Human Rights. Drew University Med & Sci. (1989-1992).
3.
Continuing Medical Education (CME) Committee. Drew Univ. Med & Sci(19891992).
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4.
6.
7.
8.
9.
Faculty Council Research Committee. Drew University Med & Sci. (1994)
Research Review Committee (RRC). Drew University Med & Sci. (1990)
Committee for the Protection of Animal Rights. Drew University Med & Sci. (1992)
Biohazard and Safety Committee. Drew University Med & Sci. (1996, 1997)
ENT Research Committee. Drew University Med & Sci. (2006, 2007)
10.Charles Drew UNIVERSITY SERVICE
Member. Drew–Meharry- Morehouse Consortium Cancer Center. (1989-1992). Activities
include; A) Join annual retreat, B) Participate Annual Symposium (Interaction between
Natural Killer cells and cancer). LA, CA. March 7, 1991, and C) Participate with lab
activities. Meharry Medical College regional Research Day. April 27, 1990
1.
Member of numerous committees:
a. Animal care and use Committee (1989-1992)
b. Protection of Human Rights Committee (1988-1992)
c. Biohazard and Safety Committee (1989-1997)
d. Space Planning Committee (1986-1992)
2.
Research training:
a. Undergraduate students in MBRS, Minority Biomedical Research (1984-1991)
b. Support Program and MARC, Minority Access to Research Careers (1984-1991)
c. Drew/UCLA Medical Students (1992-1995)
d. Numerous Residents in Department of Otolaryngology (1983-2007)
3.
Master’s of Science in Clinical Research Program at Charles Drew University (Oct 2008)
a. Biological Response Modifiers: From the Bench to the Clinic Application
11.COMMUNITY SERVICE


Judge at 10th annual St. Paul the Apostle Science Fair, 2002, 11th annual Science
Fair, 2003, 12th annual Science Fair, 2004, 13th annual Science Fair, 2005
Created a video to educate the public about a new cancer therapy. The video
was created in collaboration with Dr. Susan Kelly and Dr. Keith Norris
12. RESEARCH/GRANTS/CONTRACTS
1.
2.
Current Active Support
Source of fund: Ozell Pharmaceutical,Co.,Ltd. USA. Ghoneum (PI)
The goal of this project is to study the immunological and anti-cancer activity of an
extract from Nerium oleander leaves.
Total support $213,498 (2005-2008). Direct Cost: $71,166 2005-06, $81,000 2006-07,
$15,000 2007-08
Source of fund: Daiwa Pharmaceutical,Co.,Ltd. Japan.
The goal of this project is to study the effects of a modified arabinoxylan from rice bran
on cancer cell apoptosis and immunopotentiation.
Total support $300,000 (2003-2006). Direct Cost: $75,000 per year
April 2008 support: $30,000.
Role: PI
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3.
1.
2.
3.
4.
1.
2.
3.
4.
Source of fund: Venex Co., Ltd. Japan
The goal of this project is to study the effects of nanodiamond on immune cell function
and cancer cell apoptosis.
Total support $60,000 (July 1, 2008 – June 30, 2009). Direct Cost $60,000 (June 2008)
Pending Support
Ghoneum (PI). Revised 6/1/07
Source of fund: Ro1 grant NIH/NCI
Project Title: Yeast therapy for the treatment of breast cancer.
The goal of this project is to study the apoptotic effect of yeast in triggering apoptosis of
breast cancer cells.
40% effort, $ 675,000 (direct cost), total support, $ 961,875 (2007-2010).
Ghoneum (PI)
Source of fund: Ro1 grant NIH/NCI
Project Title: Rice Bran: Complementary Approaches to Therapy in Leukemia.
The goal of this project is to characterize the ability of a unique product (MGN-3) to
sensitize cancer cells to pro-apoptotic-inducing agents and seek to identify bioactive
subfraction(s).
40% effort, $ 275,000 (direct cost), total support, $ 400,000 (2008-2010).
Ghoneum (PI)
Source of fund: California Breast Cancer Research Program (CBCRP)
Project Title: Yeast Therapy for the Treatment of Metastatic Breast Cancer
The goal of this project is to conduct pre-clinical studies in mice for the ability of baker’s
yeast to control metastatic breast cancer, and to elucidate the mechanism behind this
effect.
40% effort, $31,500 (direct cost), total support $181,500 (2008-2010)
Source of fund: Daiwa Health Development (DHD), Los Angeles, California.
The goal of this project is to study, in clinical trials, the anti-HIV activity of
Arabinoxylan rice bran.
Total support $20,000 (Sept. 1, 2008 – Aug. 31, 2009). Direct Cost $20,000
Previous Support:
NIH Support History
NIH/MBRS (Project Director), Grant #1818-11237-56100, Drew University Med & Sci.
Title: NK levels and tumor development in responsive and non-responsive strains of
mice. %50 effort, first year support $32, 000 (direct cost), total support $100,000 (198689).
NIH/MBRS (Co-PI), Grant #1818-1237-56100, Drew University Med & Sci.
Title: Immunologic profile in Vitiligo.
First year support $40,000 (direct cost), total support $120,000 (1986-89).
BRSG (PI) Grant # 1913-1237 Drew University Med & Sci..
Title: Effect of smoke and stress on NK activity and possible generation of LAK cells for
the therapy of head and neck cancer.
$4,950/yr for 7 yrs. Budget amount for supplies (1985-91).
NIH/MBRS (Project Director),
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5.
Title: Effects of methylcholanthrene on signal transduction of NK Cells.
40% effort, first year support $55, 000 (direct cost), total support, $220, 000 (1992-1996).
NIH/MBRS (Co-PI),
Title: Role of phenolic chemicals and viral agents in the pathogenesis of immune
aberration in vitiligo.
20% effort, First year support $65, 000 (direct cost), total support $260, 000 (19921996).
Pharmaceutical Company (Private) Funding History
6.
Ghoneum (PI)
Source of funds Foundation Basic Research Inst Oncology, Japan.
Title:Effects of Biological Response Modifiers on Immune system.
Total support $75, 000 (1997-98).
7.
Ghoneum (PI)
Source of funds Effective Microorganism Research Organization (EMRO) Japan.
Title: Anti-HIV activity of effective microorganisms (EMX).
Total support $75, 000 (1997-1998).
8.
Ghoneum (PI)
Source of funds Artificial Cell Membrane (A.C.M.) Co., Ltd. Japan.
The goal of this project is to study the action of biological response modifier (MRN-100)
on immune system to fight cancer and HIV.
Total support $600,000 (1996-2004). Direct Cost: $75,000 per year
13.TEACHING SUPERVISION
Duties include: Teaching, training, supervising and collaborating.
A.
POSTDOCTORAL FELLOWS
NAME
YEAR
AFFILIATION
Ismail A. Sadek, Ph.D. 1986-87
Professor Dept Zool
(6mo)
Univ Alexandria, Egypt
Mohamed Faisal
1987 (3mo)
Asso. Professor Univ
Alexandria, Egypt
Kochi Suzuki
1988-90 (2yrs) Iatron Labs Inc, Tokyo,
Japan
Helen Hanerson, B.S.
1991-92
Biology teacher
(3mo)
Dominguez High Sch,
Compton, CA, USA
Zeinab Ismail, Ph.D.
1992
Asso. Professor Dept.
Microbiol, Menai
Univ., Egypt
B.
MASTER AND Ph.D
NAME
YEAR
Diane Wallace1986-88
Kecskes, M.S.
(2yrs)
Yehia El Sepai, Ph.D.
1987-88
(6mo)
AFFILIATION
Univ. Dominguez
Hills, LA, CA (Master)
Ain-Shames Univ.,
Cairo, Egypt (Ph.D.)
TITLE OF STUDY
Phylogeny NK cells
Effect of stress on NK
activity
Mechanism of NK cell
cytotoxicity
training
Immunomodulation of NK
cells BRMs
TITLE OF STUDY
NK activity in chemically
induced tumor
Immunology of diabetes
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Aronnas Banionis,
M.S.
1990-91
Cal State Northridge,
CA (Master)
Mabrouk Ghonaim,
Ph.D.
1992-94
Microbiol Fac. Med.,
Menoufia Univ.,
Sheebin El-kom, Egypt
(Ph.D.)
C.
Changes in NK cell
receptors by
methylcholanthrene
NK cells in liver cancer
Resident Training
Activities (i.e. training efforts, publications related to instruction, etc.)
1. Training residents in modern techniques in immunology and cancer.
2. Help residents to write articles and be published in peer-reviewed journals.
3. Help residents to participate in national and international conferences.
Residents at Department of Otolaryngology – Teaching and training started 1986-2007.
NAME
YEAR
Title of Study
15. Jimmy Brown, MD
1986-2007
Biology and Therapy of Cancer. Data published in
several peer-reviewed journals in 2003 (see reference
63), 2004 (reference 66) and 2005 (reference 72).
Data also presented at several national and
international symposia in 1986, 1996, 1999, and
2004.
1. Walter Stevens, MD
1986-87 (6mo) Stress and Immunity. Data published in Immunol.
60:461-65. (1987).
2. Lonnie Smith, MD
1987 (3mo)
Mechanisms of NK Activation
3. Lisa Perry-Gilkes,
1988 (3mo)
Phagocytic Tumor Cell. Data published in Nat.
MD
Immun. Cell Growth Reg. 6(2) 77-87 (1987).
6. Keith Jackson, MD
1988-91
Immunity and Gender in Mice. Data published in Int.
J. Immunopath. & Pharmac. 4(1)9-18 (1991).
Natural Killer Cells and Host Defense (Ades, EW,
and Lopes, C. Eds.) Basel, Karger, pp. 278-284
(1989).
Data also presented at 16th annual NIH-MBRS
symp., Los Angeles, CA, Oct. 13-15 (1988).
4. Duane Taylor, MD
1989 (3mo)
Immunomodulation of NK Cells
5. Joan Lewis, MD
1989 (3mo)
Immunology of Head and Neck Cancer
7. Dennard Ellison, MD 1990-91 (1yr)
Measurements of Immune Function
8. Majid Torabi, MD
1991-92 (8mo) Aging and Immunity. Data presented at FASEB
meeting. Anaheim, CA. Apr. 5-9 (1992).
9. Guillaume, A.
1994 (3mo)
Immunomodulation in Mice
10. McClain, A.
1994-1995
Immunomodulation using hemicellulose compound.
Data published in Int. J. Immunotherapy. XI(1)23-28
(1995).
11. Rayan Osborne
1999-2002
Candida albicans and Lymphatic Tumor cells. Data
presented at Triological Society Western Section
Meeting. Pasadena, CA. Feb. 1-3, 2002.
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12. Jacin Hamilton
2002-2004
13. Christopher Regala
2002-2004
BRMs and Cancer Apoptosis. Presented at Int. Res.
Conf. on Food, Nutrition and Cancer. Washington,
DC. July 15-16, 2004.
Concomittans Bacteria and Immunity. Article
Published in Acta Otolaryngologica 124:621-7
(2004).
Residents from Other Departments
1. Harvey Allen, MD
1989 (6mo)
2.Ghassan Al-Jazayrly, MD
1990-91
3. Mark Wimbley, MD.
1994 (6mo)
MEDICAL STUDENTS
NAME
YEAR
Jeff Thomas, MD
1986 (3mo)
NK cells in cervical cancer
Phagocytosis by tumor cells
Anticancer activity by AHCC in vitro
D.
Harvey Allen, MD
1987 (3mo)
Paula Bailey, MD
1988 (3mo)
Amina E. Hussein, MD
1994 (1mo)
Franklin Gbenedio, MD 1995 (2mo)
E.
AFFILIATION
Drew Univ Med &
Sci
Bowman Gray Sch.
Med, Wake Forrest
Univ., WinstonSalem, NC
“
Med. Res. Inst.,
Alexandria, Univ.
Egypt
College Osteopath
Med. Pac. College
Plaza, Pomona, CA
TITLE OF STUDY
Mechanism of
cytotoxicity on single
cell level
Phagocytic tumor
cells
Cytotoxicity of tumor
infiltrating NK cells
Effect of Tributyltin
on NK activity
Molecular
mechanism of
interleukin-2 induced
activated kill (LAK)
cells
SENIOR HIGH SCHOOL STUDENTS/ UNDERGRADUATE STUDENTS
Many of the students’ collaborative works presented in symposia and appear in
publications, and most students have graduated from medical school.
1.
Tina Molina, Sonya Thomas, Yenneh Betru, Loyola Marymount Univ., Los
Angeles. Project Title: NK cells in responsive and non-responsive strains of
mice. (1986-1988).
2.
Ronald Hesslup, LA Southwest College. Project title: Effect of chemical
carcinogens in NK cytotoxic pathway (1989-91).
3.
Andre Whitmore, Cal State Univ. Dominguez Hills, CA. Project Title: Changes
in the cell receptors in NK infiltrating tumors (1990-91).
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4.
5.
6.
7.
8.
9.
10.
11.
12.
Francisco Romero, Cal State Univ. Dominguez Hills, CA. Project Title: Defect
in signal transduction of NK cells by chemical carcinogens (1990-92).
Loc Pham, Cal-Et. Univ. Project Title: NK cells in aging mice (1992).
Sharmane Gray, Cal State Univ. Dominguez Hills, CA. Project Title: Effects of
methylcholanthrene on NK cell receptors. (1992-1994).
Richard Jordan and John Robles, Loyola Marymount Univ., LA. Project Title:
Anticarcinogenic and immunopotentiation by BRMs (1992-1994).
Kim Cunningham, Loyola Marymount Univ., LA. Project Title: Effect of
methylcholanthrene on signal transduction of NK cells (1993-95).
Von Suk Kin, Junj Kim, Sivi Popot, Sally Carmody, Vanende Rowkie, Mario
Rethual, Rodena Vataparast, Sieng Deng, Sanna Elarabi, Trang Vu and Maynard
Concepcion (King/Drew Magnet High School). Each student involved in year
long project. Title: Relation between NK Stress and Cancer. (1993-1995)
Projects were honored by County Science Fair every year, 1986-89 and 1992-97.
Los Angeles Pediatric Society Program. Six students, summer, 1988 and 6
students, summer, 1989-1995.
Minority High School Research Apprentice- 8 weeks; 1985, 1989-95. Melo Yap,
student, Magnet High School. Received Honorable Mention, California Science
Fair, May 1999 and May 2000.
14.COLLABORATION
1.
2.
3.
4.
5.
6.
7.
Professor Edwin L. Cooper, Ph.D., UCLA Sch Med, Dept Neurobio. Title: Phylogeny of
NK cells.
Reynolds Saglie, MD, UCLA Sch Dent, Dept Peridont. Title: Role of NK cells against
infection with Actinobacillus Actinocomtans.
Paul Kelly, MD and Pearl Grimes, MD, Drew Univ Med & Sci, Dept Dermat. Title:
Immunology of Vitiligo.
Ali Ansari, Ph.D., Drew Univ Med & Sci, Dept Chem. Title: Role of LDH, Acpase in
cytotoxicity of NK cells.
Groesbeck Parham, MD, Edward Savage, MD, Drew Univ Med & Sci, Dept Gyn. Title:
NK cell activity in cervical and ovarian cancer.
Ram Chillar, MD, Drew Univ Med & Sci, Dept Hem & Onco. Title: Natural
cytotoxicity in breast cancer.
Gabriele Peters, Ph.D., Inst Hydrobiol & Fischereiwissenschaft, Univ Hamburg,
Germany. Title: Effects of stress on NK activity of Fish.
15.WORKSHOPS ORGANIZED
1. Organized Energy Medicine Workshop. Johrei Science Workshop #37. Phoenix, AZ.
June 21-25, 1995.
2. Organized Immunology Workshop, between Japan Immunologic Society of Oriental
Medicine and Drew Univ. Drew Univ., Los Angeles, CA, Nov 1990, April 1991, 1992,
1995, 2005 and 2007.
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Initial: _____ June 27, 2009
3. Organized 5th International Workshop on Arabinoxylan Rice Bran. Shared with Dr. MinZer Shay, Vice President of Taiwan Medical University, Chairman of Department of
Nutrition. Taiwan Medical University, Taipei, Taiwan. August 9, 2008.
4. Organized CAM (Complementary and Alternative Medicine) for the treatment of Cancer
and Hepatitis B and C. Shared with Dr. Mai Hong Bang, MD PhD, Head of Division and
Dept. of Hepato-Gastroenterology at 108 Military Central Hospital and Institute of
Clinical Medical and Pharmaceutical Science. Hanoi, Vietnam, August 12, 2008.
16.INTERNATIONAL CONFERENCES ORGANIZED
1.
2.
First International Conference on Royal Agaricus and its Implications for Cancer
Treatment at Drew University of Medicine and Science, Los Angeles, CA, July 26, 1995.
Organized the first International Conference on Alternative Medicine at Drew University
of Medicine and Science, Los Angeles, CA. July 27, 1999.
17.REPRESENTATIVE PRESENTATIONS AND ABSTRACTS
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
Egami N, Ghoneum M, Kikuta A and Ijiri K. Effects of radiation on life span of
lymphoid tissues in the fish, Oryzias latipes. The 2nd Radiation Biology Center Int.
Symp. on Perspective in the Modification of the Rate of Aging, Tokyo, Japan. 20 (1978).
Ghoneum M, Ijiri K and Egami N. Morphological observation on the effects of
gamma irradiation during embryonic stage on thymus in Oryzias latipes. 6th Int. Cong.
Rad. Res., Tokyo, Japan 243 (1979).
Ghoneum M and Egami N. Effects of low dose of  irradiation on thymus size in the
adult fish Oryzias latipes. Symposium on Radiation Effects on Aquatic Organisms,
Zushi, Japan., 19 (1978).
Ghoneum M and Egami N. Age related changes in morphology of the thymus of the
fish Oryzias latipes. Symposium of Comparative Biol. of Aging in the Asia/Oceania
Congress of Gerontology, Melbourne, Australia (1980).
Ghoneum M, Ijiri K, and Egami N. Gamma ray effects on thymus in fish Oryzias
latipes. J. Rad. Res. 21(1),29 (1980). Abst.
Ghoneum M, Egami N and Ijiri K. Effect of -rays on the embryonic development of
the thymus in Oryzias latipes. J. Rad. Res., 22(1),46 (1981) Abstract.
Ghoneum M, Egami N and Ijiri K. Effect of corticosteroids on thymus of the fish
Oryzias latipes. 2nd Int. Soc. Devel. Comp. Immunol. (ISDCI) Cong, UCLA, Los
Angeles, CA. Aug. 14-19 (1983).
Ghoneum M. Co-chaired session entitled “Phylogeny and Ontogeny of host/parasite
relationship II and Immunodevelopmental process and aging I”. 2nd Int. Soc. of Devel.
Comp. Immunol. (ISDCI) Cong. UCLA, Los Angeles, CA. Aug 14-19 (1983).
Wallace-Kecskes D, Ghoneum M and Alfred L. Role of biological response modifiers
in tumor formation. 12th ann. NIH-MBRS Symposium, Washington, DC. Apr 10-13
(1984).
Webster V, Shacks S, Ghoneum M and Alfred L. Murine T-cell subsets in DBA and
C3H mice treated with C-parvum and MCA. 12th Ann NIH-MBRS Symp, Washington,
DC. Apr 10-13 (1984).
12
Initial: _____ June 27, 2009
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
Ghoneum M, Salem F and Cooper E. Susceptibility of NK cells to cytotoxicity by
tumor cells. Symposium of Federation of American Soc for Exp. Biol. (FASEB),
Anaheim, CA, Apr. 22-25 (1985).
Ghoneum M, Gill G, Stein E, Salem F and Cooper E. Phagocytosis of large
granular lymphocytes and other leukocytes by tumor cells. Abstracts in: Nat. Immunity
and Cell Growth Regul. 4(5):249-250 (1985) presented at Int. Symp. Nat Immunity and
biol response modification for th therapy of cancer and other diseases. Honolulu, Hawaii,
Nov. 10-12, (directed by R. Herberman).
Wojdani A, Ghoneum M and Cheung GPC. Alterations in cell-mediated immune
function by environmental chemicals. 19th Advanced Seminar and 20th Ann Meeting.
American Acad. Environ. Med. Strasburg, CO. Nov. 1-5 (1985).
Ghoneum M. et al. Augmentation of Natural Killer cell lytic activity by a biological
response modifier and its suppression by chemical carcinogens. 13th MBRS Symp.,
Miami, FA 1985).
Grimes P, Ghoneum M and Kelly P. T Cell profiles in Vitiligo. Symp. Soc. Invest.
Dermat., Inc. Washington, DC, May 17 (1985).
Ansari A, Ghoneum M and Kahler D. Unusual lactic dehydrogenase (LD) isoenzymes
in murine splenic lymphocyte populations. American Association for Clin. Chem.
Georgia World Cong. Center, Atlanta, Georgia, July 21-26 (1985).
Grimes P, Ghoneum M, Kelly P and Alfred L. Las Vegas, Nevada, Dec. (1985).
Ghoneum M, Grimes P, Kelly P. Natural Killer cell activity in patients with Vitiligo.
Conference of the Soc. Invest. Dermat., Washington, DC, May 1-4 (1986).
Bright-Asare P, Enrique C, Brown J, Yamini S and Ghoneum M. Alterations in
duodenal mucosal inulin clearance (A measure of mucosal permeability) is mechanism of
duodenal ulcer formation by acidified ethanol. Am. Gastroentero. Assoc., Am. Assoc.
Study of liver disease, San Francisco, CA. May 18-21 (1986).
Grimes P, Gollapudi S, Ghoneum M, Thadepalli H and Kelly P. Functional
abnormalities of lymphocytes in Vitiligo. 13th Int. Pigment Cell Conference, Tucson,
AZ, Oct. 5-9 (1986).
Ghoneum M, Gill G, Stein E, Ansari A and Cooper E. Bacterial phagocytosis by
tumor cell in vitro. 6th Int. Symp. Immunol., Toronto, Canada, July 1-6 (1986).
Gollapudi S, Ghoneum M, Gill G, Thadepalli H, Hyun M and Chillar, R. Natural
Killer cell activity in sickle cell patients. 28th Annual meeting Am. Soc. Hemat. San
Francisco, CA (1986).
Ghoneum M, Molina T and Gill G. In vivo role of natural killer cells against chemical
carcinogens in DBA/2 mice. 14th ann NIH-MBRS Symp., Washington, DC, Oct. (1987).
Grimes P, Ghoneum M and Kelly P. Natural Cell mediated cytotoxicity in vitiligo. Am.
Acad. Dermat., New Orleans, LA, Dec. 6-12 (1987).
Grimes P, Ghoneum M and Kelly P. Abnormal natural killer cell activity in vitiligo.
World Cong. Dermat., Berlin, Germany. May 24-29 (1987).
Ghoneum M, Saglie R, Soheil K and Marfany A. NK cell activity in Actinobacillus
Actinomycetemocomitan infected rats. Int. Am. Assoc. Dent. Res., Montreal, PQ,
Canada, Mar 9-13 (1988).
Ghoneum M , Betru Y and Gill G. Age related changes in NK activity in response to
immune suppression and carcinogenesis by methylcholanthrene. Abstract In: Natural
13
Initial: _____ June 27, 2009
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
Immunity and cell Growth Regul., 7(1):56-57. Presented at 5th Int. Workshop on NK
cells, Hilton Head Island, SC, Mar 22-25 (1988).
Ghoneum M. Immunology and Cancer. National Medical Assoc (NMA) Ann Meeting,
Los Angeles, Ca, July 30- Aug 4 (1988).
Ghoneum M. Lymphoid cell destruction by tumor cells. Natl. Med. Assoc. (NMA) Ann
Meeting, Los Angeles, CA, July 30-Aug 4 (1988).
Ghoneum M. Natural Killer cell activity and cancer. Natl. Med. Assoc. (NMA) Ann
Meeting, Los Angeles, CA, July 30-Aug 4 (1988).
Thomas S and Ghoneum, M. Effect of a carcinogenic methylcholanthrene on
lymphokine production in various strains of mice. 16th ann NIH_MBRS Symp., Los
Angeles, CA Oct. 13-15 (1988).
Betru Y, Ghoneum M, Jackson K and Gill G. Intersex difference to tumor development.
16th ann NIH-MBRS symp., Los Angeles, CA, Oct. 13-15 (1988).
Betru Y, Gill G, Thomas S, Jackson K, and Ghoneum M. Age related decline in natural
killer cell activity in female C3H mice. 16th ann NIH-MBRS symp., Los Angeles, CA,
Oct. 13-15 (1988).
Ghoneum M. Inhibition of SK cell activity in frogs by certain drugs and sugars.
Immunology Abstracts 13(2):80 (1988).
Ghoneum M, Saglie R and Gill G.
Long term effect of actinobacillus
atinomycetemcomitant on natural killer cell activity and T cell populations in rats. 3rd
Ann. Con. Clin. Immunol., (ACCI) San Francisco, CA. Nov. 4-7 (1988).
Ansari A, Ghoneum M and Trevejo R. Lactic dehydrogenase (LD) activity of murine
natural killer (NK) cells in young and old mice and its implications. 41st Natl. Meet.
Am. Assoc. Clin. Chem. Atlanta, GA. July 23-27 (1989).
Ghoneum M, Sadek IA, Gill G and Cooper EL. Vitamin C and its effect on natural
killer cell activity.
2nd BICON on Chemotherapy of infectious diseases and
malignancies. Montreux, Switzerland. Mar 5-8 (1989).
Ghoneum M, El-Sepai Y and Gill G. Increased natural killer cell activity in allograft
pancreatic transplantation of diabetic rats. 4th Ann. Con. Clin. Immunol. (ACCI),
Arlington, VA, Nov. 4-6 (1989).
Thomas S, Ghoneum M and Gill G. Effect of gamma irradiation on murine natural
killer activity. 4th Ann. Con. Clin. Immunol. Arlington, VA, Nov. 4-6 (1989).
Attend: Western Region AIDS Education Project. Impact of HIV & other STD on
African-Americans. A program of the comprehensive health center San Diego, CA. At
Drew Univ. Med & Sci. Mar (1990).
Elsen D, Ghoneum M, Gill G and Lewis J. Effect of gamma irradiation on human
natural killer activity in vitro. 38th Ann Meet Rad. Res. Soc. 10th Ann. Meet. N. Am.
Hyperthermia Group. Apr 7-12 (1990).
Ghoneum M, Suzuki K and Gollapudi S. Reversal of age related decline in natural
killer activity by phorbol myristate acetate. Am. Soc. Biochem. and Mol Biochem/Am
Assoc. Immunologists (ASBMB/AAI) New Orleans, LA, June 3-7 (1990).
Ghoneum M, Gollapudi S and Gill G. Inhibition of tumor cell growth by quinolone
derivatives in vitro. Ann. Meet. Am. Acad. Otolaryngol.- Head and Neck Surgery. San
Diego, CA. Sept. (1990).
14
Initial: _____ June 27, 2009
44.
45.
46.
47.
48.
49.
50.
51.
52.
53.
54.
55.
56.
57.
58.
59.
Taylor D, Ghoneum M and Gill G. Natural killer activity in postoperative head and
neck cancer patients. Ann. Meet. Am. Acad. Otolaryngol.-Head and Neck Surgery. San
Diego, CA. Sept. (1990).
Ghoneum M, Suzuki K and Gill G. Suppression of natural killer activity by
transplantable tumor in the cheek of mouse. 3rd Int. Head and Neck Onco. Res. Con.
Las Vegas, Nevada, USA. Sept. 26-28 (1990).
Ghoneum M, Sadik I and Cooper E. Variability of NK cells in anuran amphibians. 6th
Int. Symp. on Diagnostic Quantitative Pathology (Morphometry in morphological
diagnosis) Basel/Switzerland. Aug 29-Sept. 1 (1990).
Hesslup R, Ghoneum M and Gollapudi S. Suppression of murine natural killer activity
of protein kinase C inhibitor. MBRS-MARC symp. Nashville, TN. Oct. 11-13 (1990).
Hesslup R, Suzuki K, Ghoneum M and Salem F. Susceptibility of old mice to
development of tumor transplantation. MBRS-MARC symp. Nashville, TN. Oct. 11-13
(1990).
Ghoneum M, Gill G and Suzuki K. TNF stimulates phagocytosis by NK cells. 3rd Int.
Con. On tumor necrotic factor and related cytokines. Makuhari, Chiba, Japan. Nov. 2125 (1990).
Ghoneum M. Mechanism of cervical cancer escape immunesurveillance. 2nd Ann.
Symp. Drew-Meharry-Morehouse Consort. Cancer Ctr. Drew Univ Med & Sci., LA,
CA. Mar 26 (1991).
Ghoneum M. Annual Workshop of the Japanese Society of Oriental Medicine (JSION).
Los Angeles, CA. April 8, 1991.
Attended: Chronic Fatigue Syndrome: Current theory and treatment. Chronic Fatigue
Syndrom Con. The Radisson Bel-Air Summit Hotel, Bel Air, CA. May 18-19 (1991).
Ghoneum M, Banionis A, Oppenheimer S, Gill G and Romero F. Demonstration of
involvement mannose residues on NK cell cytotoxicity using lectin coupled beads.
Natural Immun. & Cell Growth Regul. 10,132-133 (1991). The VII Int. Workshop on
Natural Killer Cells. Stockholm (Lidingo) Sweden. June 4-7 (1991).
Ghoneum M, Elison D and Gill G. Effect of chemotherapy on natural killer cell
receptors. 96th Ann. Conven. Natl Med Assoc. (NMA) and Sci Assem. And 1991 Conv.
Aux Natl Med. Assoc. Inc. Indianapolis, IN. July 25-Aug 1 (1991).
Romero F, Ghoneum M, Banionis A and Oppenheimer S. Action of carcinogenic
methylcholanthrene on mannose receptor determinants of NK cells. Natl. NIGMS
Minority Programs Symp. Wash., DC., Nov. 3-6 (1991).
Gray S, Ghoneum M and Gill G. Phagocytosis by NK cells suppresses their anti tumor
activity. Natl NIGMS Minority Programs Symp. Wash., DC. Nov. 3-6 (1991).
Ghoneum M, Ninomiya Y, Torabi M, Gill G. and Wojdani A. Active Hemicellulose
Compound (AHCC) enhance NK Cell activity of aged mice in vivo. FASEB meeting.
Anaheim, CA. Apr. 5-9 (1992).
Wojdani A and Ghoneum M. In vivo enhancement of human NK activity by vitamin
C. FASEB meeting. Anaheim, CA. Apr. 5-9 (1992).
Ghoneum M, Phyllis P, Ninomiya Y, Ghonaim M and Gill G. Enhancement of human
NK cell activity in vivo by active hemicellulose compound (AHCC). 7th Ann con. Clin.
Immunol. Phil, PA Nov. 13-15 (1992).
15
Initial: _____ June 27, 2009
60.
61.
62.
63.
64.
65.
66.
67.
68.
69.
70.
71.
72.
73.
74.
75.
76.
Ghoneum, M., et al. Enhancement of NK cell activity in cancer patients by active
hemicellulose compound (AHCC). Adjuvant Nutrition in Cancer Treatment Symp.
Tulsa, OK. Nov. 6-7 (1992).
Ghoneum M. Cancer Immunotherapy. The first post-graduate educational meeting on
“The state of art of management of breast cancer”. Menoufia, Fac. Med., Egypt. Dec.
17-18 (1992).
Ghoneum, M. AHCC treatment of AIDS patients, clinical trials. Int. Day of AIDS in
Egypt. Menoufia, Fac. Med., Egypt. Dec. 25 (1992).
Ghoneum M. Cancer and immunity.. Seminar for 638 members of the Japanese
Immunology Soc. Oriental Med. Keio Plaza Hotel, Tokyo, Japan. Jan. 22 (1993).
Ghoneum, M. Activated Natural Killer (NK) cells Therapy for Cancer. Int. Conf. On Alt.
Med. Cairo, Univ. Cairo, Egypt. Nov 24 (1993).
Ghoneum M. AHCC-Immunotherapy against cancer. National Cancer Inst. Cairo,
Egypt. Nov. (1993).
Ghoneum M. Some current topics in Natural Immunity and recent research in our
laboratory. Abst. Lect. in Cairo Univ. Cairo, Egypt. Nov. 1993.
Cunningham R and Ghoneum M. Action of carcinogenic methylcholanthrene on
granularity of NK cells. NIGMS sypm. Atlanta, GA. Nov. 3-6 (1993).
Ghoneum M, Salem F and Gill G. AHCC as conjunctive therapy in multiple myeloma
and ovarian carcinoma. Symp. Adj. nutrition in cancer treatment. San Diego, CA. Mar
17 (1994).
Ghoneum M, Wimbley M, Guillaume A, Cunningham K and Attallah N.
Immunomodulation and anticancer effects by active hemicellulose compound (AHCC)
therapy. Interdisciplinary world con. on antimicrobial and anticancer drugs. Geneva,
Switzerland. Apr. 25-27 (1994).
Ghoneum M. NK-immunomodulation by active hemicellulose compound (AHCC) in 17
cancer patients. 2nd meeting of the Soc. Natural Immunity-Taormina, Italy. May 25-28
1994. Proceedings Nat. Immun. 13, 228 (1994)
Ghoneum M and Priestly J. AHCC immunotherapy in AIDS patients. 10th Intl. Con.
AIDS. Yokohama, Japan. 7-12. Aug (1994).
Ghoneum M, Torabi M and Gill G. AHCC immunotherapy in cancer patients Joint
Con. Modern developments in cancer therapeutics. Taipei, Taiwan. 7-11, Nov (1994).
Ghoneum M, Mermel O, Williams L, Attallah N and Hashimoto Y. Susceptibility of
propolis-treated tumor cells to human natural killer cell activity in vitro. Impact of
Biotechnology on Predictive Oncology and Therapy. Boston, Massachusetts. 11-13, Dec
(1994)
Ghoneum, M and Higa T. Susceptibility of EMX-treated tumor cells to NK cell
cytotoxicity in vitro. Am. Assoc. for Cancer Res. Con. "Molecular biol of cancer:
Implications for prevention and therapy". Maui, Hawaii. 13-18 Feb. (1995).
Ghoneum M. Royal Agaricus mushroom enhances murine natural killer cell activity in
vivo. 9th Int. Congress of Immunology. San Francisco, CA. July 23-29 (1995).
Ghoneum, M. First International Conference on Royal Agaricus and its Implications for
Cancer Treatment. Workshop. Drew University of Medicine and Science, Los Angeles,
CA. July 26, 1995.
16
Initial: _____ June 27, 2009
77.
78.
79.
80.
81.
82.
83.
84.
85.
86.
87.
88.
89.
90.
Ghoneum M and Namatalla G. In vivo enhancement of murine and human natural
killer cell activity by Natura propolis. Adjuvant nutrition in cancer treatment symposium.
Tampa, FL. Sept. 28-30 (1995).
Ghoneum M. Immunomodulatory and anti-cancer properties of MGN-3, a modified
xylose from rice bran in 5 patients with breast cancer. Int. Conference “Cancer, the
interference between basic and applied research” sponsored by American Association for
Cancer Research. Baltimore, MD. Nov. 5-8, (1995).
Ghoneum, M and Namatalla, G. Effective microorganisms (EMX) enhances murine NK
cell activity in vivo and in vitro. 3rd Int. NK cell Workshop, LA, CA. Dec.2-6 (1995).
Ghoneum M and Namatalla G. NK immunomodulatory function in 27 cancer patient
by MGN-3, a modified arabinoxylane from rice bran. Abstract, proceedings of the 87th
Ann. Meeting of American Assoc. for Cancer Res. Washington, DC., Apr 20-24 (1996).
Ghoneum M and Kijima Y. Induction of human natural killer (NK) cell activity by water (MRN-100). Ann. Conf. on Clinical Immun. New Orleans, LA May 31-June 3
(1996).
Ghoneum M, Namatalla G and Chung K. Effect of MGN-3 on human NK cell activity
and interferon- synthesis in vitro Fed. Assoc. Soc. Exp. Biol. (FASEB). New Orleans,
June 2-6 (1996).
Ghoneum M. Anti-HIV activity by MGN-3 in vitro. 11th Int. Conference on AIDS.
Vancouver, Canada 7-12 July (1996).
Ghoneum M and Ogura T. In vivo immunomodulation of human NK cell activity by
MCM, a crystallized mixture of minerals and trace elements from sea water. 3rd Int.
Symp. Impact of Cancer Biotechnology. Diagnostic and Prognostic Indicators. Nice,
France. Oct 26-28 (1996). Abstract, proceedings of Cancer Detection & Prev. 20 (5) 311
(1996).
Ghoneum M and Ogura T. Inhibition of tumor cell growth by MCM, A crystallized
mixture of minerals and trace elements from sea water. 3rd. Int. Symp. Impact of Cancer
Biotechnology. Diagnostic and prognostic indicators. Nice, France. Oct. 26-28 (1996).
Abstract, proceedings of Cancer Detection & Prev. 20 (5) 347 (1996).
Ghoneum M, Higa T, Brown J, Namatalla G and Gill G. Counteracting toxicity of
chemotherapeutic agent (5FU) on Human NK cell activity in vitro with effective
microorganism-EMX. 6th Ann. Schweppe Colloquium in the Basic Sciences. Cancer
susceptibility genes and cancer gene therapy. Chicago, IL. Oct. 28-29 (1996).
Ghoneum M. Immunomodulation and anti-cancer activity by EM-X. 13th Annual
Conference on Effective Microorganisms (EM) Research and Application. Okinawa,
Japan. Nov. 9-10 (1996).
Ghoneum M. Role of biological modification on natural immunity: mechanism of
activation and clinical implication. The 1st Int. Symposium on Consciousness, New
Medicine, New Energy. Sponsored by the Japanese Green Cross Society. Tokyo, Japan.
Nov. 22 (1996).
Ghoneum M, Choong K and Namatalla G. -water (MRN-100) possesses anti-HIV
activity in vitro. Palm Springs symposium on HIV/AIDS foundation of HIV therapy.
Palm Springs, CA., Mar. 13-16 (1997).
Ghoneum M, Namatalla G and Kijima Y. Phenotypic analysis of human lymphocyte
sub-populations post treatment with -water (MRN-100). Abstract, proceedings of the
17
Initial: _____ June 27, 2009
91.
92.
93.
94.
95.
96.
97.
98.
99.
100.
101.
102.
103.
104.
88th Ann. Meeting of American Assoc. for Cancer Res. San Diego, CA., Apr 12-16
(1997).
Ghoneum M. Basic Research and Clinical Aspects of Biological Response Modifiers.
USA-Japan joint workshop on Alternative Medicine. Drew University of Medicine and
Science. Los Angeles, CA. May 30, 1997
Ghoneum M and Vuong A. Immunodulatory function of active royal jelly peptide
(ARP) on human NK cell activity. Proceedings in the 26th annual meeting of the
American College of Clinical Pharmacology. Phoenix, Az. Sept. 18-20 (1997).
Ghoneum M, Choong K and Higa T. Anti-HIV activity of Effective Microorganisms
(EMX) in vitro. Proceedings of the 6th International European Conference on HIV.
Hamburg, Germany, Oct. 11-15 (1997).
Ghoneum
M.
Imunomodulatory function and counteracting toxicity of
chemotherapeutic agent (5FU) on human natural killer (NK) cell activity by BioActivation Energy (BAE) Water in vitro. Immunotherapeutic Strategies for cancer. San
Diego, CA. Feb. 25-26 (1998).
Ghoneum M. Effect of Johrei on NK cell activity. 2nd Int. Conference on the
Psychology of consciousness, Energy medicine and dynamic change. La Jolla, CA. Mar.
25-28 (1998).
Ghoneum M. Counteracting toxicity of chemotherapeutic agent on human natural killer
(NK) cell activity by Active Royal Jelly Peptide (ARP) in vitro. Exp. Biol. San
Francisco, CA. Apr. 18-22 (1998).
Ghoneum M and Maida H. MGN-3 immunotherapy for the treatment of cancer. The
1st Int. Symp. on Disease Prevention by Ib6 and other rice compounds. Takaragaike,
Kyoto, Japan. June 8-9, 1998.
Ghoneum M. Enhancement of human NK Activity in vivo by Johrei. Eighth Annual
International Society for the Study of Subtle Energies & Energy Medicine (ISSSEEM)
Conference. Boulder, Colorado; The Future of Energy Medicine-Integrating Science and
Spirit June 18-24, 1998.
Ghoneum M and Jewett A. Synergistic effect of modified arabinoxylane (MGN-3) and
low dose of recombinant IL-2 on human NK cell activity and TNF- production. Am.
Acad. of Anti-aging. Med. Anti-aging Med. for the office-based physician. New Jersey.
Aug. 15-16, 1998.
Ghoneum M. Stimulating natural killer cells. 26th Annual Cancer Convention.
Alternative therapies. Pasadena. Los Angeles, Ca. Sept. 5-7, 1998.
Ghoneum M. NK immunorestoration in cancer patients by MRN-100, an iron based
compound derived from bivalent and tervalent ferrate. 4th Int. Symp. on predictive
oncology and therapy. Nice, France. Oct. 24-27, 1998.
Ghoneum M. MRN-100 depletes glutathione level and increases human head and neck
carcinoma Calu-27 sensitivity to natural killer cell cytotoxicity. 4th Int. Symp. on
predictive oncology and therapy. Nice, France. Oct. 24-27, 1998.
Ghoneum M. Immune enhancement from systemic use of an arabinoxylane compound.
Integrated Anti-Aging Med. (INCALM) Reno, Nevada. Oct. 29-Nov. 2, 1998.
Ghoneum M. NK immunorestoration of cancer patients by MGN-3, a modified
arabinoxylan rice bran (study of 32 patients up to 4 years). 6th Int. Cong. Anti-aging and
Biomed. Technologies. Las Vegas, NV. Dec. 11-13, 1998.
18
Initial: _____ June 27, 2009
105.
106.
107.
108.
109.
110.
111.
112.
113.
114.
115.
116.
117.
118.
Ghoneum M. Progress in Immunotherapy of Breast Cancer Using MGN-3. First Annual
Breast Health Symposium. Encino, CA. June 19, 1999
Ghoneum M. MGN-3 Update and Role of Functional Food in Alternative Medicine. 1st
International Workshop on Alternative Medicine. Drew University of Medicine and
Science. Los Angeles, Ca. July 27, 1999
Ghoneum M. Immunostimulation and cancer prevention. 7th Int. Cong. Anti-aging and
Biomed. Technologies. Las Vegas, NV. Dec. 11-13, 1999.
Ghoneum M. Immunostimulation, cancer prevention and MGN-3. The Second World
Conference of Nutrition and Vitamin Therapy. San Francisco, CA. February 20-22, 2000.
Ghoneum M. Anti-HIV activity by MGN-3 an arabinoxylan compound from rice bran.
Int. Conf. on HIV/AIDS & MALARIA in Africa. Atlanta, Georgia. April 13-15, 2000.
Ghoneum M. Anticancer activity by MGN-3 (bio bran), modified arabinoxylan rice bran.
2nd Int. Workshop on Alternative Medicine. Sponsored by the Japan Functional Food
Research Association (JAFRA). Cambridge Christ’s College, England. September 5,
2000.
Tachiki K, Uyemura K, Ghoneum M, Makinodan T. and Yamaguchi, D. Inhibition of
tumor cell growth and modulation of cytokine production by the iron based compound
MRN-100. American Association for Cancer Research (AACR) Proceedings Cytokines
and Cancer: Regulation, Angiogenesis, and Clinical Applications. Vail, Colorado.
September 20-24, 2000.
Ghoneum M, Tachiki K, Uyemura K, Makinodan T, Makhijani N and Yamaguchi, D.
Natural biological response modifier (MGN-3) shown to be effective against tumor cell
growth. 8th Int. Cong. on Anti-aging and Biomed. Technologies. Las Vegas, NV. Dec.
14-17, 2000.
Uyemura K, Tachiki K, Ghoneum M, Makinodan T, Makhijani N and Yamaguchi D.
MGN-3, a novel antitumor agent. 92nd Annual Meeting, American Association for Cancer
Research (AACR). New Orleans, LA. March 24-28, 2001. Proceedings AACR, vol. 42,
March 2001.
Ghoneum M, Grewal I, Osborne R, Kanamori G and Tsao J. Phagocytosis of candida
albicans by lymphatic tumor cells in vitro. Triological Society Western Section Meeting.
Pasadena, CA. Feb. 1-3, 2002.
Ghoneum M and Gollapudi S. MGN-3 potentiates death receptor –induced apoptosis in
cancer cells. Amercian Association for cancer Research (AACR). Frontiers in Cancer
Prevention Research. Boston, MA. Oct. 14-18, 2002
Ghoneum M. Apoptosis – a novel approach to cancer treatment. Japan Functional Food
Research Association (JAFRA) Seminar. Cancer Forum 21. Tokyo, Japan. July 27,
2003.
Ghoneum M and Gollapudi S. A novel approach to breast cancer therapy: Modified
arabinoxylan rice bran (MGN-3/Biobran) enhances apoptosis of human breast cancer
cells following phagocytosis of Sacchromyces cerevisiae, the baker’s yeast, in vitro.
American Association for Cancer Research (AACR). Advances in Breast Cancer
Research Genetics, Biology, and Clinical Implications. Huntington Beach, CA. October
8 – 12, 2003
Ghoneum M and Gollapudi S. Modified arabinoxylan rice bran (MGN-3/Biobran)
potentiates apoptosis in cancer cells induced by multiple anti-cancer agents in vitro. 7th
19
Initial: _____ June 27, 2009
119.
120.
121.
122.
123.
124.
125.
126.
127.
128.
129.
International Symposium on Predictive Oncology & Intervention Strategies. Nice,
France. February 7-10, 2004
Ghoneum M. 2004 Alternative medicine seminar. Kingsport, Tennessee. April 10,2004
Ghoneum M, Hamilton J and Gollapudi S. Alternative approach to cancer therapy –
modified arabinoxylan rice bran (MGN3/Biobran), enhances apoptosis in human breast
cancer cells. Int. Res. Conf. on Food, Nutrition and Cancer. Washington, DC. July 15-16,
2004.
Ghoneum M, Golapudi S, Hamilton J, Brown J and Ninomiya K. Human Squamous
Cell Carcinoma of the Tongue Exhibits Phagocytosis against Baker's Yeast. Annual
Meeting of the American Academy of Otolaryngology-Head and Neck Surgery
Foundation in New York, New York, September 19-22, 2004.
Ghoneum M. Role of immunotherapy in cancer. 3 rd Scientific Meeting and 2nd
Oncology Symposium of the Filipino-Chinese Medical Society, Inc. Manila, July 18,
2005.
Ghoneum M, Seto Y, Takeuchi K, Sato S, Chonghasawat A, Yamada T and
Gollapudi S. Thymax, a liquid extract of thymus, induces apoptosis in human cancer
cell lines in vitro. 4th Int. Congress on Targeted Therapies in Cancer. Washington, DC.
August 26-28, 2005.
Ghoneum M and Gollapudi S. Effect of Modified Arabinoxylan from Rice Bran
(MGN-3/Biobran) on Human Neutrophils and Monocyte function in vitro. Federation of
Clinical Immunology Societies (FOCIS) annual meeting. San Francisco, CA. June 1-5,
2006.
Ghoneum M, Ozel HZ and Gollapudi S. Nerium oleander leaf extract (NOE-4)
sensitizes human Burkett cell lymphoma (Raji) to heman cytotoxicity mediated by
Natural Killer cells. Federation of Clinical Immunology Societies (FOCIS) annual
meeting. San Francisco, CA. June 1-5, 2006.
Ghoneum M and Gollapudi S. Prevention of oxidative stress-induced apoptosis in
lymphocytes by HydroFerrate Fluid from ACM Systems®. Federation of Clinical
Immunology Societies (FOCIS) annual meeting. San Francisco, CA. June 1-5, 2006.
Badr El-Din NK, Noaman E and Ghoneum M. In Vivo tumor inhibitory effects of
nutritional rice bran supplement MGN-3/biobran on Ehrlich Carcinoma–bearing mice.
AICR/WCRF International Research Conference on Food, Nutrition and Cancer in
Washington, D.C. July 13-14, 2006.
Ghoneum M, Tam H, Ozel HZ and Gollapudi S. Glutathione potentiates the anti-tumor
activity of Nerium Oleander leaf extract (NOE-4). AICR/WCRF International Research
Conference on Food, Nutrition and Cancer in Washington, D.C. July 13-14, 2006.
Badr El-Din NK, Noaman E and Ghoneum M. Rice bran supplement (MGN-3/Biobran)
suppresses tumor growth via modulating cytokine production and increasing apoptotic
level in Ehrlich Carcinoma-bearing mice. Federation of Clinical Immunology Societies
(FOCIS) annual meeting. San Diego, CA. July 7-11,2007
18.INVITED LECTURES AND SEMINARS
1.
Ghoneum, M. Environmental factors affecting NK cells. Japanese Inst Environ Studies.
Japan. July 1987.
2.
Ghoneum, M. Tumor cell-NK cell interaction. Japan, Tokyo Univ. Aug 1987.
20
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3.
4.
5.
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21.
Ghoneum, M. How Cancer Cells Escape Immune System Detection. Drew Meharry
Morehouse Consortium, Los Angeles, CA. May 25, 1989.
Ghoneum, M. Effect of aging on immune response to stress and cancer. VA Hospital
Wadsworth, Los Angeles, CA. Oct 27, November 3, 1989.
Ghoneum, M. How you protect yourself against cancer. Medical Magnet High School,
LA, CA. Feb 5, 1990.
Ghoneum, M. How Does Cancer Escape Natural Killer Cells Immune Surveillance?
Biology Colloquium. California State University Northridge. Los Angeles, CA.
September 14, 1990.
Ghoneum, M. Natural Killer Cells Activity in Relation to Cancer, Aging and Stress.
Annual Workshop Japanese Immunology Society of Oriental Medicine. Drew University
of Medicine and Science. Los Angeles, CA. November 27, 1990.
Ghoneum, M. Natural Killer Cells and Cancer. Biomedical Research Seminar. . Drew
University of Medicine and Science. Los Angeles, CA. March 8, 1991.
Ghoneum, M. Natural killer cells update. Dept of Psychology UCLA, CA. Nov 1991.
Ghoneum, M. The Battle Between NK Cell and Cancer Cell. Biological Research
Seminar, Research Training Institute. Drew University of Medicine and Science. Los
Angeles, CA. January 17, 1992.
Ghoneum, M. Interaction between NK and tumor cells. MARC Program, San Diego State
Univ. Mar 10, 1992.
Ghoneum, M. Immunomodulation. Research Training Institute, Biomedical Research
Seminar. MBRS. Drew University of Medicine and Science. Los Angeles, CA. March
13, 1992.
Ghoneum, M. Phagocytic Activity of Cervical Cancer Cells. Grand Rounds, The KDMC
OB/GYN Department. Drew University of Medicine and Science. Los Angeles, CA.
September 24, 1992.
Ghoneum, M. Lecture “Cancer and Immunity”. Sponsored by Japanese Immunological
Society of Oriental Medicine. Tokyo, Japan. January 23, 1993.
Ghoneum, M. “Active Hemicellulose Compound Action on Immune System” Int. Conf.
On Alternative Medicine, Cairo, Egypt. Nov 20, 1993.
Ghoneum, M. Scientific Approach to Johrei – The Future of Energy Medicine. Johrei
Fellowship Sponsored Conference “Scientific Approach to Johrei.” NIH Conference.
Silver Spring, MD. May 6, 1994.
Ghoneum, M. Natural Killer Cells Immunotherapy for Cancer. Biology Colloquium.
California State University Northridge. Los Angeles, Ca. May 13 1994.
Ghoneum, M. Activating NK cells by BRMs. Cleveland Chiropractic College. July 28,
1994.
Ghoneum, M., Sakakibara K. The Effects of Johrei on Brain Waves and the Immune
System Johrei Fellowship Sponsored Conference “Scientific Approach to Johrei”. Los
Angeles, CA. December 4, 1994.
Ghoneum, M. Naturally Activating the Immune System. University California San
Francisco (UCSF) Medical Center. February 4, 1995.
Ghoneum, M. The Future of Immunomodulation Using Energy Medicine. Johrei
Fellowship Sponsored Conference “The Future of Energy Medicine.” NIH. Bethesda,
MD. June 28, 1995
21
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38.
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40.
Ghoneum, M. Naturally Activating the Immune System. Johrei Fellowship Sponsored
Conference “The Future of Energy Medicine”. Boulder, CO. August 11-12, 1995.
Ghoneum, M. Immunomodulation of human natural killer (NK) cell activity by effective
microorganisms (EMX). IBC USA Conference on Immunotherapeutic Strategies for
Cancer – Novel Vaccine Strategies. San Diego, CA. December 7-8, 1995.
Ghoneum, M. Natural killer cell-tumor cell interaction. Imperial University (Taikoku)
Japan. July 1996.
Ghoneum, M. The Future of Immunomodulation Using Energy Medicine. Johrei
Fellowship Sponsored Conference. Harvard School of Public Health. Dec, 9, 1996.
Ghoneum, M. The Future of Alternative Medicine for the Treatment of Cancer.
University of Arkansas for Medical Science (UAMS).July 1997.
Ghoneum, M. Arabinoxylan Rice Bran: Enhancement of Immune System and
Mechanisms Behind its Effect. San Diego State University(SDSU). Aug.7, 1997.
Ghoneum, M. Natural killer (NK) system update. Cairo University, Egypt. Aug. 1997.
Torabi, M., Ghoneum, M., and Gill, G. Immunomodulatory Function of Active
Hemicellulose Compound (AHCC) on Human NK Cell Cytotoxicity In Vivo.
Otolaryngology Conference. Los Angeles, CA, 1998.
Ghoenum, M. Energy Medicine Update.Tucson Jhorei Center. Tucson, AZ.June 22, 1998
Ghoneum, M. Stress Cancer and Immune Therapy. The SGI – USA Culture Department
Sponsored Conference on Natural Health Alternatives. Los Angeles, CA. May 22, 1999.
Ghoneum, M. (NNFA) Las Vegas, NV. June 7, 2001
Ghoneum, M. Natural biological response modifiers for immunostimulation and disease
imbalance. Seminar on Continuing Education for pharmacists, sponsored by Bergen
Brunswig Health Care Congress. Course #338-000-01-013-L01. Paris Hotel Los Vegas,
NV. July 13, 2001
Goldberg, B., Lane, W. and Ghoneum, M. Clinical experiences with MGN-3. Chicago,
IL. July 14, 2001
Ghoenum, M. Apoptotic Effect of Arabinoxylan Rice Bran in Leukemia, in vitro. Japan
Functional Food Research Organization (JAFRA). Osaka, Japan, July 26. 2003.
Ghoenum, M. Synergy of Arabinoxylan Rice Bran and Chemotherapy for the Treatment
of Cancer using in vitro model. Japan Functional Food Research Organization (JAFRA).
Tokyo, Japan, July 24. 2004.
Ghoneum, M. Immune Modulation by Arabinoxylan Rice Bran: Update. Basic Science
Conference, Harbor-UCLA. August 23, 2005.
Ghoenum, M. Functional Food in Relation to Cancer. Japan Functional Food Research
Association (JAFRA). Tokyo, Japan. July 19. 2005.
Ghoenum, M. Immune System Fighting Disease Status. Presentation at St. Paul Apostal
School. Los Angeles, CA. October 23, 2001, April 24, 2006.
Ghoneum M. Evaluation of functional food on enhancing immune system: An
assessment of my research for the past 25 years. Japan Functional food research
association (JAFRA) Conference on aging and immunity. Tokyo, Japan. July 29, 2007
Also invited to seminars by Medical Schools and Cancer Institutes in Japan, 1992-97; Egypt,
1993-97 and China, 1994.
22
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19.RESEARCH PAPERS – PEER REVIEWED Published
1.
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Ghoneum M. Female sex hormones and protection from gamma radiation effects on the
metabolism in some mammalian tissues. M.S. Thesis (1976). Mansoura Univ. Egypt.
Ibrahim H A, Othman A E, and Ghoneum M. Radioprotective effect of female sex
hormones on lipid metabolism in gamma irradiated female rats. Bull. Fac. Sci.,
Mansoura Univ, Egypt, NO.4 (1976).
Ibrahim H A, Othman A E, and Ghoneum M. Radioprotective effect of sex hormones
against gamma radiation effect on the general metabolism of some mammalian tissues.
III- Protein metabolism in male rats. Isotope & Rad. Res., 11(2):125-133 (1979).
Ghoneum M, Ijiri K, and Egami N. Effect of gamma irradiation during embryonic stage
on thymus in the fish Oryzias latipes. J. Radiat. Res., 20(1),14 (1979).
Ghoneum M, Ijiri K, and Egami N. A note on gamma-ray effects on the thymus in the
adult fish of Oryzias latipes. J. Fac. Sci. Univ Tokyo, 14(3), 299-304 (1979).
Ghoneum M, and Egami N. Effect of -irradiation of adult and embryo of Oryzias latipes
on thymus size. In Radiation Effects on Aquatic Organisms. (N. Egami, ed.), Japan Sci.
Soc. Press, Tokyo/Univ., Park Press, Baltimore, 135-137 (1980).
Ibrahim HA, Othman AE, and Ghoneum M. Studies on sex hormones as radioprotectors:
Nitrogen and Protein contents in female rats. Egypt. J. Physiol. Sci., 7(2):95-103 (1980).
Ghoneum M. Morphological study on radiation effects on the thymus in the fish Oryzias
latipes. Doctor Thesis (1981). Univ. Tokyo, Japan.
Ghoneum M, Egami N, and Ijiri K. Effects of acute -irradiation on the development of
the thymus in embryos and fry of Oryzias latipes. Int. J. Rad. Biol., 39(3)339-344
(1981).
Egami N, and Ghoneum M. Decrease in thymus volume by continuous -irradiation of
the fish Oryzias latipes. Workshop on Tritium radiobiology and health physics, US
Japan Fusion Cooperation Program, Chiba, B7, 11-2 (1982).
Ghoneum M, and Egami N. Age related changes in morphology of the thymus of the fish
Oryzias latipes. Exp. Geron, 17:33-40 (1982).
Ghoneum M, and Egami N. Decrease in thymus volume on Oryzias latipes following
continuous -irradiation. Proc. Workshop tritium radiobiol and health physics, Chiba,
Natl Inst. Radiol. Sci. M., 41:185-186 (1982).
Ghoneum M, Ijiri K, and Egami N. Effects of gamma-rays on morphology of the thymus
of the adult fish of Oryzias latipes. J. Radiat., Res., 23:253-259 (1982).
Ghoneum M, Ijiri K, Hamed MS, Gabr OM, and Egami N. Effects of gamma-rays on the
taste buds of embryos and adults of the fish Oryzias latipes. J. Radiat., Res., 24:278-283
(1983).
Hamed MS, Gabr OM, and Ghoneum M. Development and distribution of taste buds in
Oryzias latipes and their functional significance. Japanese J. Ichth, 31(3):335-337
(1984).
Alfred L J, Ghoneum M, Wojdani A, and Shacks S J. Alterations in NK activity and Tcell subsets during the development of chemically induced tumors: role of biological
response modifiers (BRMs). Immunobiol. 167,180 (1984).
Patel R, Soriano A, Loeb L, Ghoneum M, and Najera D. Isolation of T lymphocyte
subsets from peripheral blood using monoclonal antilymphocyte antibodies. Ann. Clin.
Lab. Sci. 15(1):66-70 (1985).
23
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37.
Ghoneum M, Gill G, and Perry L. Natural Killer cell activity in patients with carcinoma
of the larynx and hypolarynx (Letter). Laryngoscope, 96(11):1300 (1986).
Ghoneum M, Egami N, Ijiri K, and Cooper EL. Effect of corticosteroids on thymus of
the fish Oryzias latipes. Dev. Comp. Immunol. 10(1):35-44 (1986).
Grimes PE, Ghoneum M, Stockton T, Payne C, Kelly AP, and Alfred L. T cell profiles
in Vitiligo. J. Am. Acad. Dermat. 14(2):196-201 (1986).
Wojdani A, Ghoneum M, and Cheung GP. Measurements of humoral and cellular
immunity for the diagnosis of candidiasis. Clin. Ecol. 3(4), 201-207 (1986).
Gollapudi S, Ghoneum M, Gill G, Thadepalli H, Hyun M, and Chillar R. Natural Killer
(NK) cell activity in sickle-cell patients. Blood 68(124) 61a (1986).
Sadek IA, Ghoneum M, and Cooper EL. Retinoic acid and its effect on natural killer
cells in toads. J. Nut. Growth and Cancer. 4:191-197 (1987).
Sadek IA, Ghoneum M, and Cooper EL. Effect of 20-Methylcholanthrene on amphibian
natural killer cells. Dis. Aquat. Org. 3:155-158 (1987).
Ghoneum M, Ahmed I I, Egami N, and Ijiri K. Protective effect of estrone treatment of
gamma-radiation related mortalities in Oryzias latipes. Alex. J. Vet. Sci. 3(1) 195-202
(1987).
Ghoneum M, Wojdani A, and Alfred L. Effect of methylcholanthrene on human natural
killer cell cytotoxicity and lymphokine production in vitro. Immunopharm. 14:27-33
(1987).
Ghoneum M, Grimes PE, Gill G, and Kelly P. Natural cell-mediated cytotoxicity in
vitiligo. J. Am. Acad. Derm. 17(4) 600-605 (1987).
Ghoneum M, Salem F, Shum ST, Perry L, and Gill G. In situ lymphophagocytosis by
nonlympho-reticular neoplasms. Nat. Immun. Cell Growth Reg. 6(2) 77-87 (1987).
Ghoneum M, Smith CT, and Cooper EL. Membrane markers and mitogenic responses of
cytotoxic cells in anuran amphibians. Cell. Molec. Biol. 33(6) 807-817 (1987).
Ghoneum M, Cooper EL, and Smith C. Inhibition of SK cell activity in frogs by certain
drugs and sugurs. Dev. Comp. Immunol. 11:363-373 (1987).
Wojdani A, and Ghoneum M. In vivo augmentation of natural killer cell activity by
Candida albicans. Int. J. Immunoth. 9(7) 827-832 (1987).
Ghoneum M, Gill G, Assanah P, and Stevens W. Susceptibility of Natural Killer cell
activity of old rats to stress. Immunol. 60:461-65. (1987).
Ghoneum M, Gill G, Wojdani A, Payne C, and Alfred L J. Suppression of basal and
corynebacterium parvum-augmented NK activity during chemically induced tumor
development. Int. J. Immunopharm. 9(1):71-78 (1987).
Ahmed I I, Nemetallah BR, Faisal M, and Ghoneum M. The physiological adaptation of
Oreochromis niloticus and Mugil cephalus to the effect of hypoxia. Vet. Med. J.
35(3):487-563 (1987).
Smith CT, Ghoneum M, and Cooper EL. Ultrastructure of cytotoxic cells in frogs.
ACTA Zool. 69(3):125-133. (1988).
Ghoneum M, Egami N, and Ijiri K. Effect of Oestrogen treatment on the survival of
irradiated fish of the species Oryzias latipes. Folia Morph. 36(1):25-31 (1988).
Ghoneum M, Faisal M, Peters G, Ahmed I I, and Cooper EL. Suppression of natural
cytotoxic cell activity by social aggressiveness in Tilapia. Dev. Comp. Immunol. 12(3)
595-602. (1988).
24
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38.
39.
40.
41.
42.
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52.
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54.
55.
Ghoneum M, Salem F, Allen H, and Gill G. Phagocytosis of autologous lymphocytes by
cervical preneoplastic and neoplastic cells. Nat. Immunt. Cell Growth Regul. 7(4):239248 (1988).
Ghoneum M, Salem F, Gill G, Jackson K, Betru Y, and Allen H. NK cell activity and
tumor development of age-related variation to 3-methylcholanthrene. In: Natural Killer
Cells and Host Defense (Ades, EW, and Lopes, C. Eds.) Basel, Karger, pp. 278-284
(1989).
Togashi H, Ghoneum M, et al. A monoclonal antibody 1A6 to T cell recognizes a
common antigen expressed on lymphocytes from normal and leukemic patients and
inhibits NK cell activity. Hemat. Onco. 7,233-242 (1989).
Cooper EL, Peters G, Ahmed I I, Faisal M, and Ghoneum M. Aggression in Tilapia
affects immunocompetent leukocytes. Aggressive Behav. 15:13-22 (1989).
Ghoneum M, Cooper EL, and Sadik I. Variability of natural killer cell activity in anuran
amphibians. Dev. Comp. Immunol. 14:359-365 (1990).
Ghoneum M, and Grewal I. Change in tumor cell-lymphocyte interactions with age.
Hemat. Onco. 8,71-80 (1990).
Ghoneum M, Sadek IA, Gill G, and Cooper EL. Ascorbic acid suppresses natural killer
cell activity in Bufo marinus. Dis. Aquat. Org. 9:1-4 (1990).
Ghoneum M, Hussein AE, Gill G, and Alfred LJ. Suppression of murine natural killer
cells activity by tributyltin: in vivo and in vitro assessment. Environ. Res. 52, 178-186
(1990).
Ghoneum M, Jackson K, Salem F, and Gill G. Murine inter-sex difference in
methylcholanthrene induced tumor and its correlation with NK activity. Int. J.
Immunopath. & Pharmac. 4(1)9-18 (1991).
Ghoneum M, Suzuki K, and Gollapudi S. Phorbol myristate acetate corrects impaired
NK function of old mice. Scand. J. Immunol. 34;391-398 (1991).
Vojdani A, Ghoneum M, and Braubar N. Immune alteration associated with exposure to
toxic chemicals. Toxic and Industrial Health. 8(5)239-254 (1992).
Ghoneum M, Vojdani A, Suzuki K, and Gill G. Phagocytic natural killer cells. Int. J.
Immunopath and Pharmac. 6(1) 21-34 (1993).
Vojdani A, and Ghoneum M. In vivo effect of ascorbic acid on enhancement of human
natural killer cell activity. Nutrition Res. 13;753-764 (1993).
Ghoneum M. NK immunomodulation by active hemicellulose compound in 17 cancer
patients. Nat. Immunity. 13;228 (1994).
Ghoneum M, Wimbley M, Salem F, McClain A, Attallah N, and Gill G.
Immunomodulatory and anticancer effects of active hemicellulose compound (AHCC)
Int. J. Immunotherapy. XI(1)23-28 (1995).
Ghoneum M, Ghonaim M, Namatalla G. et al. NK cell activity in hepatocellular
carcinoma and its relation to the etiology of the disease J. clean Technol., Environ.
Toxicol., & Occup. Med., 5;267-284 (1996).
Ghoneum M, Vojdani A, Banionis A, Oppenheimer S, Lagos N, and Gill G. The effect
of carcinogenic methylcholanthrene on carbohydrate residues of NK cells. Int. J. Toxicol
& Industrial Health. 13(6); 727-741 (1997).
Vojdani A, Ghoneum M. et al. Elevated apoptotic cell population in patients with
Chronic Fatigue Syndrome: the pivotal role of protein kinase RNA. J. Internal Med.
242(6)465-478. (1997).
25
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57.
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60.
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70.
Vojdani A, Ghoneum M, and Choppa P. Minimizing cancer risk using molecular
techniques: A review. Toxicol & Industrial Health. 13(5), 589-626. (1997).
Ghoneum M. Anti-HIV activity in vitro of MGN-3, an activated arabinoxylan from rice
bran. Biochem. Bioph. Res. Comm. 243, 25-29 (1998).
Ghoneum M. Enhancement of human NK activity in vivo by Johrei. Proceeding of 8th
Annual Conference. The future of energy medicine: Integrating science and spirit.
Boulder, CO. June 19-24. p. 30-34. (1998).
Ghoneum M. Enhancement of human natural killer cell activity by modified
arabinoxylane from rice bran (MGN-3). Int. J. Immunotherapy. XIV(2) 89-99 (1998).
Ghoneum M, and Brown J. NK immunorestoration of cancer patients by MGN-3, a
modified arabinoxylan rice bran (study of 32 patients followed for up to 4 years). Antiaging medical therapeutics Vol. III (Klatz, R. and Goldman, R. ed.) 217-226 (1999).
Proceeding of 6th Int. Cong. Anti-aging and Biomed. Technologies. Las Vegas, NV.
Dec. 11-13, 1998.
Ghoneum M, and Ogura T. In vivo immunmodulation of human NK cell activity by
MC29, a crystallized mixture of minerals and trace elements from sea water. J. Nutrition
Research. 19 (9) 1287-98 (1999).
Ghoneum M, and Jewett A. Production of tumor necrosis factor- and interferon- from
human peripheral blood lymphocytes by MGN-3, a modified arabinoxylan from rice
bran, and its synergy with interleukin-2 in vitro. Cancer Detection & Prevention 24(4):
314-324 (2000).
Ghoneum M, Grewal I, Brown J, Osborne R, Elembabi H, and Gill G. Phagocytosis of
candida albicans by lymphatic tumour cells in vitro. Acta Histochemica. 105 (2):127133 (2003).
Ghoneum, M. and Gollapudi, S. Modified arabinoxylan rice bran (MGN-3/Biobran)
sensitizes human T cell leukemia cells to death receptors (CD95)-induced apoptosis.
Cancer Letter.201 (1) 41-49 (2003).
Ghoneum M, and Gollapudi S. Phagocytosis of candida albicans by human metastatic
and non-metastatic breast cancer cells.in vitro. Cancer Detection & Prevention.28 (1)17–
26 (2004).
Ghoneum M, Saglie R, Brown J, and Regala C., Actinobacillus actinomycetemcomitans
suppresses rat natural killer cell activity in vivo. Acta Otolaryngologica 124:621-7
(2004).
Ghoneum M, and Gollapudi S. Induction of apoptosis in human breast cancer cells by
Saccharomyces cerevisiae, the baker's yeast, in vitro. Anticancer Res. 24 (3A):1455-63
(2004).
Ghoneum M, and Abedi S. Enhancement of natural killer cell activity of aged mice by
modified arabinoxylan rice bran (MGN-3/Biobran). J Pharmacy Pharmacol. 56 (12):
1581-1588 (2004).
Ghoneum M, and Matsuura M. Augmentation of macrophage phagocytosis by modified
arabinoxylan rice bran (MGN-3/biobran). Int J Immunopathol Pharmacol. 17(3):283-292
(2004).
Ghoneum M, Gollapudi S. Modified arabinoxylan rice bran (MGN-3/Biobran) enhances
yeast-induced apoptosis in human breast cancer cells in vitro. Anticancer Res. 25:859870 (2005).
26
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71.
72.
73.
74.
75.
76.
77.
78.
79.
80.
81.
82.
83.
Ghoneum M, Gollapudi S. Synergistic role of arabinoxylan rice bran (MGN-3/Biobran)
in S. cerevisiae-induced apoptosis of monolayer breast cancer MCF-7 Cells. Anticancer
Res. 25:(6) 4187-96 (2005).
Ghoneum M, Gollapudi S, Hamilton J, and Brown J. Human squamous cell carcinoma of
the tongue and colon undergoes apoptosis upon phagocytosis of Saccharomyces
cerevisiae, the baker’s yeast, in vitro. Anticancer Res. 25 (2A) 981-9 (2005).
Ghoneum M, and Gollapudi S. Apoptosis of breast cancer MCF-7 cells in vitro is induced
specifically by yeast and not by fungal mycelia. Anticancer Res. 26 (3) 2013-2022 (2006)
Ghoneum M, Wang L, Agrawal S and Gollapudi S. Yeast therapy for the treatment of
breast cancer: A nude mice model study. In Vivo. 21(1) 251-8 (2007).
Ghoneum M, Badr El-Din N, Noaman E and Tolentino L. Saccharomyces cerevisiae, the
Baker’s yeast, suppresses the growth of Ehrlich carcinoma-bearing mice. Cancer
Immunology Immunotherapy. 57(4), 581-92. 2008.
Ghoneum M, Matsuura M, and Gollapudi S. Modified Arabinoxylan Rice Bran (MGN3/biobran) enhances intracellular killing of microbes by human phagocytic cells in vitro.
Int J Immunopathol Pharmacol. 21 (1), 87-95. 2008.
Badr El-Din N, Noaman E, and Ghoneum M. In vivo tumor inhibitory effects of
nutritional rice bran supplement MGN-3/biobran on Ehrlich Carcinoma–bearing mice.
Nutrition and Cancer. 60 (2) 235-244. 2008.
Gollapudi S. and Ghoneum M. MGN-3/ Biobran, modified arabinoxylan rice bran,
sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin. Cancer
Detection and Prevention. 32 (1):1-6. 2008.
Ghoneum M, Seto Y, Sato S ,Ghoneum A, Braga M and Gollapudi S. Gross thymic
extract, Thymax, induces apoptosis in human Breast cancer cells in vitro through the
mitochondrial pathway. Anticancer Res. 28 (3A); 1603-1610. 2008.
Noaman E, Badr El-Din N, Bibars M, Abou Mossallam A, and Ghoneum M..
Antioxidant potential by arabinoxylan rice bran, MGN-3/Biobran, represents a
mechanism for its oncostatic effect against murine Solid Ehrlich Carcinoma. Cancer
Letters. 268; 348-359. 2008.
Ghoneum M, Matsuura M, Braga M, and Gollapudi S. S. cerevisiae induces apoptosis in
human metastatic breast cancer cells by mechanisms by altering intracellular Ca2+and the
ratio of Bax and Bcl-2. Int. J. Oncology 33(3); 533-539. 2008.
Ghoneum M and Gollapudi S. Susceptibility of Human Prostate Cancer Cells (LNCaP) to
the Apoptotic Effect of Marina Crystal Minerals (MCM) in vitro. Oncology Reports. 22
(1); 155-159. 2009.
Ghoneum M, Matsuura M and Gollapudi S. An iron-based beverage, HydroFerrate Fluid,
MRN-100, alleviates oxidative stress in murine lymphocytes in vitro. Nutrition J. 8(1);
18. 2009.
20. RESEARCH PAPERS – PEER REVIEWED In Press
84.
Ghoneum M and Shaheen M. MRN-100, an Iron-Based Compound Possesses Anti-HIV
Activity in vitro. ECAM (In press). 2009.
27
Initial: _____ June 27, 2009
21. RESEARCH PAPERS – PEER REVIEWED Submitted
85.
Ghoneum M, Seto Y, and Agrawal S. Activation of human monocyte derived dendritic
cells
by Thymax, a gross thymic extract, in vitro. Anticancer Res. Submitted. 2009
86.
Ghoneum M, Tolentino L, Seto Y, Gollapudi S, and Agrawal S. Immune modulatory
function by Thymax, gross thymic extract, in an aged mice model. . In Vivo.
Submitted.2009
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23. BOOKS
Ghoneum, M., Gill, G., Stein, E., Salem, F. and Cooper, E. In vitro tumor cell
phagocytosis of large granular lymphocytes and other leukocytes. In Natural Immunity,
Cancer and Biological Response Modification (Lotzova, E. and Herberman, RB., Eds.)
pp.104-113, Karger Basel (1986). (*Book chapter-in English).
Ghoneum, M. AHCC, a new biological response modifier. 1993. Huseki J. 1, 89-95.
(*Book chapter-in Japanese).
Ghoneum, M. Win against cancer . 1994. AHCC a new weapon against cancer. pp. 209257. Kabushikigaisha, DHC Tokyo, Japan. (*book chapter-in Japanese)
Ghoneum,M. Nutrition and cancer.1995. Role of Immune system. pp.131-198.
Kobunsha, Tokyo, Japan. (*Book chapter-in Japanese).
Cancer the killer disease of Adults. 1995. AHCC a new Biological Response Modifier.
pp. 121-161. Uraku shuppansha, Tokyo, Japan. (*Book chapter-in Japanese).
Kita,H and Ghoneum, M. Cell war. 1995. Metamol shuppan Tokyo, Japan. (*Book
chapter-in Japanese).
Kita, H. and Ghoneum, M. AHCC therapy for cancer. 1996. Metamol shuppan Tokyo,
Japan. (*Book chapter-in Japanese).
Ghoneum, M. Anti-cancer power (Koganryoku). 1998. Shufunotomu. Tokyo. Japan.
(*Book chapter-in Japanese).
Lane, W., Baxter, S. and Ghoneum, M. The Immune Power (In English) 1999. Avery
Publishing Group, Garden City Park, New York.
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